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Query: [O] KOG0717 Molecular chaperone (DnaJ superfamily), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEVEGQIGRVDDVKDDFNVILVSTTMKCHYEVLEVERDADDDKIKKNYRKLALKWHPDKNPDRIEECTQQFRLLQAAYDVLSDPREREFYDRHRESILKGKNTDFEEQSTDLFPYFTASCYQGYENDKNGFFTVYRKVFNILVSEEYDAYNDSTIVYPEFGDKDTDLEQTVNGFYGFWSSFSTTRSFAWLDHYDITQASNRFESRQIDQENKKFRDVGKQERNEQIRNLVAFVRKRDPRVKAYREILEQKKLEAHKKQADNRKKQIAKNQELANSYLNDKEAEAARLAHLIEVSLQMAEDYDTCSDECDEEGEELPYCVVCSKSFKTVNAKLNHENSKQHIRQLNELKKHMKEEDSTIFTEAEPKPDETPKGKKNKRKDRKKGNGIFDVEETEAVEAEIQEAPPVENEQPEEEEKECTPEVVKKEKKKRRADKNQNPSATVEEEAPKSTEPKSAICDKCREVFDSRTRLFAHLQETGHATLLINKPGEKGQKKAKNKKGQRGNKGDDEDWLast
1 -149.000[O] KOG0717 Molecular chaperone (DnaJ superfamily)  ali  100  1MEVEGQIGRVDDVKDDFNVILVSTTMKCHYEVLEVERDADDDKIKKNYRKLALKWHPDKNPDRIEECTQQFRLLQAAYDVLSDPREREFYDRHRESILKGKNTDFEEQSTDLFPYFTASCYQGYENDKNGFFTVYRKVFNILVSEEYDAYNDSTIVYPEFGDKDTDLEQTVNGFYGFWSSFSTTRSFAWLDHYDITQASNRFESRQIDQENKKFRDVGKQERNEQIRNLVAFVRKRDPRVKAYREILEQKKLEAHKKQADNRKKQIAKNQELANSYLNDKEAEAARLAHLIEVSLQMAEDYDTCSDECDEEGEELPYCVVCSKSFKTVNAKLNHENSKQHIRQLNELKKHMKEEDSTIFTEAEPKPDETPKGKKNKRKDRKKGNGIFDVEETEAVEAEIQEAPPVENEQPEEEEKECTPEVVKKEKKKRRADKNQNPSATVEEEAPKSTEPKSAICDKCREVFDSRTRLFAHLQETGHATLLINKPGEKGQKKAKNKKGQRGNKGDDEDW 510
2 -95.600[JO] COG5269 Ribosome-associated chaperone zuotin  ali follow..  17  71.PDELLFDTELADEDLLTHDARDWKTADLYAAMGLSKRATESQIIKAHRKQVVKYHPDKQSAGSLDQDGFFKIIQKAFETLTDSNKRAQYDSCDFVADVPPPKK---------------------GTDYDFYEAWGPVFEAEARFSKK-------TPIPSLGNKDSSKKEVEQFYAFWHRFDSWRTFEFLDEDVPDDSSNRDHKRYIERKNKAARDKKKTADNARLVKLVERAVSEDPRIKMFKEEEKKEKERRKWEREAGARAEAEAKAKAEAEAKAKAESEAKANASAKADKK---------KAKEAAKAAKKKNKRAIRNSAKEADYFGDADKATTIDEQVGLIVDSLNDEELVSTADKIKANAAGAKEVLKESAKTIVDSGKLPSSLLSY.................................................................................................................... 431
3 -88.600[O] KOG0724 Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains  ali follow..  18  98.DKEKEYVPSFNSYANKGKKKSGTQQQDHYALLGLSNLATEDQIRKSYREAALKHHPDKLAKKKDEIESRFKAIQEAYEVLMDPTRRRIFDSTDEFDDEVPSD----------------------CLPQDFFKVFGPAFKRNARWSVNQ---------PDLGDENTPLKDVDKFYNFWYAFKSWREFPDEEEHDLEQADSREERRWMEKENAKKTVKARKEEHARIRTLVDNAYRKDPRIVKRKEEEKAEKQQKKDAKIQAKKKQEEDAAIAAEEEKRRKEEEEKRAAESAQ------------QQKKTKEREKKLLRKERNRLRTLSAPLVAQRLLDISEEDIENLCMSLNTEQLQNLCDKMGNKEGLELAKVIKDGCNSSRNDEAESKEKVSKKTNGGTEPTTRVSQLDSSTQKKQPSVEEILKATKTVLLQKPDSAKAFDSFLEKRKPSASITSPLSTREELGESLPTMTTTTNAKPSKETVVGKSSSSQSSDNNGEVGGSSDADSW 607
4 -42.700[O] KOG0714 Molecular chaperone (DnaJ superfamily)  ali follow..  36  1........................MGVDFYKVLEVDRSANDDELKKAYRKLAMKWHPDKNPNNKKEAEAKFKQISEAYDVLSDPQKRAIYEQYGEEGLNQAPPPGAGGGYPGGSDAGASFRFNPRSADDIFSEFFG...................................................................................................................................................................................................................................................................................................................................................................................... 112
5 -42.400[O] KOG1150 Predicted molecular chaperone (DnaJ superfamily)  ali follow..  14  41IEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDEEIKKRFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKERKKQ-LKKEGKPTIVEEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEEWQKNFEESRDGRVDSWRNFQANTKGKKEKKNRTFLRPPKVKMEQR.................................................................................................................................................................................................................................................................................................... 263
6 -41.400[O] KOG0719 Molecular chaperone (DnaJ superfamily)  ali follow..  18  28........................MDIDPYSVLGVEKDASDELIRRAYRKKALQHHPDRIHDEKVEARIEFDKVAIAYGVLSDKKRRKHYDKTGQLRETDADID------------------------FDWKEWLDELYQGVVSGETLNEFKA-----SYQYSEEEKCDVLKAYEKGKGSMDV--KISKYKRFAPNEKKRKRRAKAAEREAQEAEEKRRKAGASDEEALSALIRSRQKRMYNLISNLESKYSKSSTKPKKSKKSRSKE.................................................................................................................................................................................................................................................. 282
7 -41.300[O] KOG0713 Molecular chaperone (DnaJ superfamily)  ali follow..  35  9...................SSAPANRRDPYEVLCVSKDANDQEIKSAYRKLALKYHPDKNANN-PDASELFKEVAFSYSILSDPEKRRHYDNAGFEALDADGMDMEIDLSNL----------------GTVNTMFAALFSK................................................................................................................................................................................................................................................................................................................................................................................. 113
8 -38.300[O] KOG0691 Molecular chaperone (DnaJ superfamily)  ali follow..  37  3........................KETEFYDVLGVSPTATEAEIKKAYYIKARQVHPDKNPND-PQAAHNFQALGEAYQVLSDPGQRQAYDTSGKSGISTE......................................................................................................................................................................................................................................................................................................................................................................................................................... 96
9 -38.000[O] KOG0716 Molecular chaperone (DnaJ superfamily)  ali follow..  28  42...................SSSSITDFDLYDLLGIDRSSDKSQIKSAYRALQKRCHPDIAG---DPGHDMAIILNEAYQLLSDPISRQAYDKEQAKLEELRGYTGK.................................................................................................................................................................................................................................................................................................................................................................................................................... 125
10 -37.700[O] KOG0718 Molecular chaperone (DnaJ superfamily)  ali follow..  31  4.................ALSEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPDKHRDLKSQAERLFNLVHQAYEVLSDPQTRAIYDIYGKRGLEMEG........................................................................................................................................................................................................................................................................................................................................................................................................................ 90
11 -36.700[O] COG2214 DnaJ-class molecular chaperone  ali follow..  25  2........................ELKDYYAIMGVKPTDDLKTIKTAYRRLARKYHPDVSKE--PDAEARFKEVAEAWEVLSDEQRRAEYDQMWQHRNDPQFNRQFHHG------------DGQSFNAEDFDDIFSSIFG.................................................................................................................................................................................................................................................................................................................................................................................. 103
12 -32.500[O] KOG0723 Molecular chaperone (DnaJ superfamily)  ali follow..  21  90.....................QKMSRREAGLILGVSPSAGKAKIRTAHRRVMILNHPDKG------SPYVAAKINEAKDLLETTTKH....................................................................................................................................................................................................................................................................................................................................................................................................................................... 150
13 -32.200[U] COG5407 Preprotein translocase subunit Sec63  ali follow..  25  88.................ANSRLKLNIWDPYEILGIAKGTSVDDVRRHYKRLSIKFHPDKVRNTREEVEKHYIEITNAYRALTDDKTRENYALYGTP.............................................................................................................................................................................................................................................................................................................................................................................................................................. 170
14 -32.200[O] KOG0721 Molecular chaperone (DnaJ superfamily)  ali follow..  25  88.................ANSRLKLNIWDPYEILGIAKGTSVDDVRRHYKRLSIKFHPDKVRNTREEVEKHYIEITNAYRALTDDKTRENYALYGTP.............................................................................................................................................................................................................................................................................................................................................................................................................................. 170
15 -31.600[O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain  ali follow..  34  2........................SNQDFYATLGVARTATDDEIKKAYRKLAMKYHPDRNPDN-KEAEEKFKEVQKAYETLSDKEKRAMYDQYGHAAFEGGGQGGF---------------GGFGGFGGAQGFDFGDIFSQMFG.............................................................................................................................................................................................................................................................................................................................................................................. 105
16 -31.300[O] KOG0712 Molecular chaperone (DnaJ superfamily)  ali follow..  43  3........................KETKLYEVLNVDVTASQAELKKAYRKLALKYHPDKNPN----AGDKFKEISRAYEILADEEKRATYDRFGEEGLQGGGADGGMSADDLFASF.......................................................................................................................................................................................................................................................................................................................................................................................................... 90
17 -30.600[O] KOG0715 Molecular chaperone (DnaJ superfamily)  ali follow..  25  38.................ATGINNSSARNYYDVLGVSPKATREEIKKSFHELAKKFHPDTNRNN-PSAKRKFQEIREAYETLGNSERREEYDKLQYRNSDYVNNDGGDSE------------RFRRAYQSNFSDTFHKIFSE................................................................................................................................................................................................................................................................................................................................................................................. 148
18 -22.700[A] KOG3408 U1-like Zn-finger-containing protein, probabl erole in RNA processing/splicing  ali follow..  17  3............................................................................................................................................................................................................................................................................RVARKRKHHSNGNHALFRTRVYGRDLDQIHNDFDKLPIDPDLPGLGQHYCIECARYFDSSQALLVHKKGKVHKRRLKNLREEPYTQEEAEAAVNIGQPKQSVASKLADNSNVVMAD.............................................................................................................................. 124
19 -22.700[R] COG5112 U1-like Zn-finger-containing protein  ali follow..  17  3............................................................................................................................................................................................................................................................................RVARKRKHHSNGNHALFRTRVYGRDLDQIHNDFDKLPIDPDLPGLGQHYCIECARYFDSSQALLVHKKGKVHKRRLKNLREEPYTQEEAEAAVNIGQPKQSVASKLADNSNVVMAD.............................................................................................................................. 124
20 -20.000[O] KOG0720 Molecular chaperone (DnaJ superfamily)  ali follow..  36  405........................NCPDHYSALGLARNVDMAYLKREYRKKAMLVHPDKNMGN-ERAAEAFKKLQNAYEVLLDSVKQKSYDDELKR.............................................................................................................................................................................................................................................................................................................................................................................................................................. 477
21 -18.700[O] COG1076 DnaJ-domain-containing proteins 1  ali follow..  27  1.........................MSQYFTLFRIEPDIDTENLEQTYRALAARFHPDKSAFEQKQAVMMSSTINDAYRTLKNPIDRAAY.................................................................................................................................................................................................................................................................................................................................................................................................................................... 71
22 -17.500[R] KOG2785 C2H2-type Zn-finger protein  ali follow..  13  14...........................................................................................................................................................................................................................................................................RDADMQRAHYKTDWHRYNLRRKVATAEGFQERVRAQRAVAEEESKGSATYCTVCSKKFASFNAYENHLKSRRHVELEKKAVQAVNRKVEMMNEKNLEKGLGVDSVDKDAMNAAIQQAIKAQPSKLAKQQEEDSEEEEEDLDGDDWEDIDSDEELECEDTEAMDDVVEQDAEEEEAEEGPPLGAIPITDCLFCSHHSSSLMKNVAHMTKD-HSFFIP........................... 280
23 -15.300[R] KOG3183 Predicted Zn-finger protein  ali follow..  13  116...........................................................................................................................................................................................................................................................................................................................IKCRDCSIDH-------KHRFGPDHS------------------------------SGPKKPESSFSFMGFLSTNTKEAPASSSSSSRWSSLFASAEASISRLGNDISQKLQFASGNDGNSEKTQERNGKQNCGKVTVDVCPKCSRGFRDPVDLLKHIDKD-HR............................... 244
24 -14.800[K] KOG2482 Predicted C2H2-type Zn-finger protein  ali follow..  16  206.....................................................................................................................................................................................................................................................................................................................QKKLDNLQCLYCEKTFRDKNTLKDHMRKKQHRKINPK-----NREYDRFYVINYLELGKSWEEVQLEDDRELLDHQEDDWSDWEEHPASAVCLFCEKQAETIEKLYVHMEDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCYGCHVKFKSKADLRTHMEETKHTSLLPDRK........................ 377
25 -14.500[O] KOG3192 Mitochondrial J-type chaperone  ali follow..  18  84........................DSVDYFQIFGLEKEIDPGSLEGKYKDWQKKLHPDLVHNKSKKAAEQSAKVTEACRTLTKRLSRAMY.................................................................................................................................................................................................................................................................................................................................................................................................................................... 155
26 -13.200[A] KOG3454 U1 snRNP-specific protein C  ali follow..  12  4...........................................................................................................................................................................................................................................................................................................................YYCDYCDTYLTHDSP-KQHNAGYKHKANVRIYYQQFEEQQTQSLIDQRIKEHLGQT........................................................................................................................................... 61
27 -12.800[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  8  43..............................................................................................................................................................................................................................................SVHYHNQCITEAEKYGPMVRSNGESSKQKHDFDINAELFNSQWF-----------------------------------CSLCNATMTCEQDYFAHVYGKKHQEKANEVADMDYSKQQSEHPAVDKNNLTQQPDLDIYVGLSNDYP-----DINATSEQTLLAHANGKKHRVKVERFDAEQQKRQSTQHSTVDKKDYSKQQIEVDINVGLSNCYPWFCSLCNVKATCQQNLLSHANGRKHRENVELFDATQQQQLEKTTVDKKDTTVNASDG 280
28 -12.300[R] KOG4377 Zn-finger protein  ali follow..  10  321...........................................................................................................................................................................................................................................................................................................................FHCNRCHYSFCDKTRFVQH--TARHERMDTLMGDDFRQFRANMQCGVASCGYATASGAATETNHLSRIDPTEAVTASSRKTSHFHCRKCDYVCTDSNKVVAHRRLHLRQDYVRNAGFRKVGGNEQDSPGCSYAQRHTHYHCVTCDGGVLSRAQLAAHKHR--TG............................... 483
29 -12.100[A] COG5246 Splicing factor 3a, subunit 2  ali follow..  10  1................................................................................................................................................................................................................................................MNYLEGVGSKKGGGGIASESQFNLQRRKEVESLLS----------KGENVPYTFQDEKDDQVRSNPYIYKNHSGKLVCKLCNTMHMSWSSVERHLGGKKHGLNVLRRGISIEKSSLGREGQTTHDFRQQQKIIEAKQSLKNNGTIPVCKIATVKNPKNGSVGLAIQVNYSSEVKENSVDSDDKAKVPPLIRIVSGLELSDTKQKG................................................................. 195
30 -11.100[V] KOG0624 dsRNA-activated protein kinase inhibitor P58, contains TPR and DnaJ domains  ali follow..  29  352TEVNPDHREAKEGLEHAKRLKTQAGKRDYYKILGVKRNASKREITKAYRKLAQKWHPDNDEEEKKKAEKKFIDIAAAKEVLQDEEKRRQFDQ.................................................................................................................................................................................................................................................................................................................................................................................................................................. 445
31 -10.500[U] KOG4173 Alpha-SNAP protein  ali follow..  14  68...............................................................................................................................................................................................................................................................................................................VADVPEKPRVPAFACQVCCQVFDALDDYEHHYHTKRAFPSGHLLDAHILEWHDSL--------------------------------------------------------------------------------------QILSERQDMYQCLVCTEKFKTSRDRKDHMVRM-HLYPADFRFDKPKKSRSPASAEAPGDSGERSE. 200
32 -10.500[R] KOG4727 U1-like Zn-finger protein  ali follow..  16  12.........................................................................................................................................................................................................................................RTWDE--KEYSLAAQQRLLDEKEAEDIRLGKKKKDEPKVKREMLQAREYKVDLDSKVGKSV----------TKATPSAETGGFYCDVCDCVVKDSINFLDHINGKNHQRNIGMSMK--------------------------KKSTVADVRERFKLMKDKKEREKKEAQVEQLLEDVQEEEARMADFKKDKKTDNRKRKRDTRKDEEEDDDEDDSGLDPEIRAMMGFSGFSTSKR.......................................... 211
33 -10.500[O] KOG0550 Molecular chaperone (DnaJ superfamily)  ali follow..  35  322IELDASDANLRQELRRLQLELKKSKRKDHYKILGVSKEATDIEIKKAYRKLALVYHPDK--AGNLEAEARFKEVGEAYTILSDPESRRRFDS.................................................................................................................................................................................................................................................................................................................................................................................................................................. 412
34 -10.400[KD] COG5189 Putative transcriptional repressor regulating G2/M transition  ali follow..  20  591....................................................................................................................................................................................................................................................................................................................DHEEQKPFKCPVCEKTYKNQNGLKYH-RLHGHQN------------------------------------------------------------------------------QKLHENPDGTFSVIDPDSTDSFGDGMGSAKDKPYRCEVCGKRYKNLNGLKYHRGHSTH................................ 683
35 -10.400[A] COG5136 U1 snRNP-specific protein C  ali follow..  15  4...........................................................................................................................................................................................................................................................................................................................YYCEYCHSYLTTLSVRKSHLVGKNHLRITADYYRNKARDIINKHNHKRRHI................................................................................................................................................ 56
36 -10.400[A] COG5188 Splicing factor 3a, subunit 3  ali follow..  14  182..........................................................................................................................................................................LEQFHSLWLNVIKRGDCSLLQFLDILELFLDDEKYLLTPPMDRKNDRYMAFLLKLSKYVETFFFKSYALLDAAAVENLIKSDFEHS------------------------------------------------CRGSLRSEAKGIYCPFCSRWFKTSSVFESHLVGKIHKKNESKRRNFVYSEYKLHRYLKYLNDEFSRTRSFVERKLAFTANERMAEMDILTQKYEAPAYDSTEKEGAEQVDGEQRDGQLQEEHLSGKSFDMPLGPDGLP---KLHGLDREYRCEICSNVYNGRRTFERHFNEERHI............................... 447
37 -10.100[B] KOG4140 Nuclear protein Ataxin-7  ali follow..  9  8.................................................................................................................................................................................................DVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRPEDGGPGAASTSAAAMATVGERRPLPSPEVMLGQSWNLWVEASKLPGKDGTELDESFKEFGKNREDDFYLVVCNDCNQVVKPQ-AFQSH--ERRHRGNTRPMHPIQQSRVPHGRIMTPSVKVEKIHPKMDGTLLKSAVGPTCPATVSSLVKPGLNCPSIPKPTLPSPGQILNGKGLPAPPTLEKKPEDNSNNRKFLNKRLSEREFDPDIHCGVCRRAVQGRRKRFDVLLAEHKNKTREKELIRHPDSQQPPQPLRDPHPAP.... 418
38 -9.580[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  8  447.................................................................................................................................................................................................EFEEVMSRNRTVSSSAIARAVSDAAAGEYSSAIETLISLIKQHDERCKILISSLQDTLHGIEAKSYNRRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGRSVRPRKSP-------EPVVAEAAEAPSSKRYYEDRERYRSSDRERRDRDRDRDRERERDRDRHFTNDGRGLPLDPSNFTSQNPGNIKTGRPKSAAVAGGSMEKPRGQSAWDIIDTDAHWIIKQQTTSIPAPPSSQQN................................................................... 696
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Topczewski J, Godzik A., Paszewski A. The Aspergillus nidulans cysA gene encodes a novel type of serine O-acetyltransferase which is homologous to homoserine O-acetyltransferases. Microbiology. 2000 Oct;146 ( Pt 10):2695-703.