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Query: [O] KOG0741 AAA+-type ATPase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAGRSMQAARCPTDELSLTNCSVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSNDSNPYDTDKMAAEFIQQFNNQAYSVGQQLVFSFNEKLFGLLVKDIESMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFAFRVFPPEIVEQMGCIHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNLKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFDLast
1 -172.000[O] KOG0741 AAA+-type ATPase  ali  100  1MAGRSMQAARCPTDELSLTNCSVVNEKDFQSGQHVIVRTSPNHRYTFTLKTHPSVVPGSIAFSLPQRKWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSNDSNPYDTDKMAAEFIQQFNNQAYSVGQQLVFSFNEKLFGLLVKDIESMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFAFRVFPPEIVEQMGCIHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNLKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEYRVRKFLALLREEGASPLDFD 744
2 -114.000[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  21  36.......................................................................PVSTRRAIQFVQERDMSLRRIKKPILEKVV--------------------EKVLDTLKAEVEEKLASSQDLVLVDSDMEEQSDSNLMEVKDTNVINKSITSKSVGQESITGSAKRKDRRSKTNGSKRQKAEANREPPS----DISLSDIGGLDD-CINELLELVAMPIKHPEVYQYTGIHPPRGVLLHGPPGCGKTMLANALANELGVPFI-SISAPSIVSGMSGESEKKVREVFEEAKS--------LAPCLMFIDEIDAVTPKRES--AQREMERRIVAQFLTCMDELSFEKTVLVIGATNRPDSLDSALRRAGRFDREICLTVPSQDAREKILRTMAKGL----KLSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPDPLSPEELEPLAICPQDFIEALAKVQPSSKREGFATVPGVSWNNIGALKSIRVELQMAIVQPIKRPESVGISAPTGVLLWGPPGCGKTLLAKAVANESKANFISIRGPELLNKYVGESE-RAVRQVFLRARASSPCVIFFDELDAMVPRRDSLSEASSRVVNTLLTELDGLSDR-SGVYVIAATNRPDIIDPAMLRGRLDKTLLVPDAHERVEILKTLTKQTPLEEVNLDVLGERCSNF---SGADLAALVREAAVTALRSVTNADFELAFKNIKPSVSDRD 759
3 -112.000[O] COG0464 ATPases of the AAA+ class  ali follow..  23  7.STIKLKVAEADQRDIVRIDERFREKLGLKPFDVVEIKGGKSTSALIGRPYPSDAGLDIIRMDGLIRTNAKTSIGEYVDIRKADWKEAKSTFAPVAQGMQIYAPSETLKAVFMNRTVSK--------------GDFISTTSLRRSRERETFGKGVMFEDFFQDFFGQGFGPIKLQVVSTAPAGIVKITDMTQVELLPEAMEIISEQNIP----TVMYEDLGGLKDAISK-VREMIELPLKHPELFDRLGIDAPKGVLLQGPPGTGKTMLAKAVANESDAYFI-SINGPEIMSKYYGESERAIREIFEDAEK--------NAPAIIFLDEIDSIAPKRAE--VTGEVERRVVAQLLSLMDGLKARKNVIVIGATNRPEALDIALRRPGRFDREIELRVPDTEGRLEIFQIHTRGM----PLADNVNLMDFAQITYGFVGADIAALCREAAMSALRRILPKINEPEISKEILDALQVTREDFENALKDVQPSAIREILIEVPNVSWEDVGGLERVKELLKEVVEWPLKNPEDIGVEAPKGVLLYGPPGTGKTLLAKAIAHESDANFITAKGSDLLSKWYGESE-KRIAEVFTRARQVAPSIIFLDELDSLAPIRGTEPQVTARILNQLLSEMDGLEEL-RAVVVIGATNRPDIIDPALLRGRFDELILVPDEGARREIFRVHTKNMALADVDIEKLVSFTDQY---TGADIAAVCKKAGRHALREVRQKHFLQAIEETGPSVTPDT 739
4 -112.000[O] KOG0730 AAA+-type ATPase  ali follow..  22  72............DNSVVSLHPTTMEKLQLFRGDTILIKGKKRKDTVCIALADETCEEPKIRMNKVVRSNLRVRLGDVISVHQ------------------------------------------------CPDVKYGKRVHILPVDDTVEGVTGNLFDAYLKPYFLEAYRPVRKGVIETDPAEYCVVAPDTEIFCEGEPVKREDEERLD----EVGYDDVGGVRK-QMAQIRELVELPLRHPQLFKSIGVKPPKGILLYGPPGSGKTLIARAVANETGAFFF-CINGPEIMSKLAGESESNLRKAFEEAEK--------NAPSIIFIDEIDSIAPKREK--TNGEVERRIVSQLLTLMDGLKSRAHVIVMGATNRPNSIDPALRRFGRFDREIDIGVPDEIGRLEVLRIHTKNM----KLAEDVDLERISKDTHGYVGADLAALCTEAALQCIREKMDVIDLEDIDAEILNSMAVSNEHFHTALGNSNPSALRETVVEVPNVSWEDIGGLENVKRELQETVQYPVEHPEKFGMSPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESE-ANVREIFDKARQSAPCVLFFDELDSIATQRGNAGGAADRVLNQLLTEMDGMNAK-KTVFIIGATNRPDIIDSALLRGRLDQLIYIPDEDSRLNIFKACLRKSPVADVDVTALAKYTQGF---SGADITEICQRACKYAIREIRAAHFEESMKYARRSVSDAD 788
5 -79.900[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  16  375.....................................................................................................................................................................................................................YRSKVPMPLQEETVNI-LASVLSPPLCPSA----LASKLRVAVLLHGIPGCGKRTVVKYVARRLGLHVVE-FSCHSLLASSERKTSTALAQTFNMARR--------YSPTILLLRHFDVFKNLGGSLGDRVGVSFEIASVIRELTEPVSNGDQVLLIASAESTEGISPTIRRC--FSHEIRMGSLNDEQRSEMLSQSLQGVSQFLNISSDEFMKGLVGQTSGFLPRDLQALVADAGANLYISQESETKKQASQIDNSTEKLTAKEDFTKALDRSKKRNASALAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLFGLRKRSGVLLYGPPGTGKTLLAKAVATECSLNFLSVKGPELINMYIGESE-KNVRDIFEKARSARPCVIFFDELDSLAPARGDSGGVMDRVVSQMLAEIDGLSDSSQDLFIIGASNRPDLIDPALLRGRFDKLLYVADASYRERVLKALTRKFKLEDVSLYSVAKKCP--STFTGADMYALCADAWFQAAKRVEYVDFIKAMDQLSPSLSITE 957
6 -69.800[O] KOG0737 AAA+-type ATPase  ali follow..  12  55...............................................................................................................................................................................................................VDGRESSVTFDEFPYLSEKTRLLLTSAAYVHLKQSDISKHTR-PGSKAILLSGPADTEQVWMRQERTWTLRRHTSGNSASSKRSANLCFDERLFLQSLYKVLVSISE-----TNPIIIYLRDVEKLCQSE-----------RFYKLFQRLLTKLS--GPVLVLGSEDDCQEVGEGISA--LFPYNIEIRPPEDENQLMSWKTRFEDDMKVIQFQDNKNHIAEVLAANDLECDDLGSICHADTMFLSSHIEEQEGQGCFEDSLKLDTNIDSKEVAPDNEFEKRIRPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDE-KNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEAMRKIKNEFMTHWDGLMSNGDRILVLAATNRPFDLDEAIIR-RFERRIMVPSVESREKILRTLLSKEKTENLDFQELAQMTDGYS---GSDLKNFCTTAAYRPVRELSMEDMKVAKSQVAASFAAE. 697
7 -67.000[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  23  20.............................................................................MDLSTADEEDLYGRLKSLERQLEFTDIQEEYVKDEQKNLKREL--LRAQEEVKRIQSVPLVIGQFMEMVDQNNGIVGSTTGSNYYVRILSTINR---ELLKPSASVALHRHSNALVDVLPPEADSSISLLSQSEKPDVSYNDIGGCDIQKQEI-REAVELPLTHHELYKQIGIDPPRGVLLYGPPGTGKTMLAKAVANHTTAAFI-RVVGSEFVQKYLGEGPRMVRDVFRLAKE--------NAPAIIFIDEVDAIATARDAQTGADREVQRILMELLNQMDGFDQTVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLVFQVCTSKMN----LSDEVDLEDYVSRPDKISAAEIAAICQEAGMHAVRK---------------NRYVILPKDFEKGYRANVKKPDTD.......................................................................................................................................................................................................................................................... 403
8 -66.300[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  26  62...............................................................................LKLERIKDYLMMEDEFIRNQERLKPQDEKNEEERSKVDDLRGTPMSVGNL-------------EEIIDDNHAIVSTSVGSEHYVSILSFVDK---DQLEPGCSVLLNHKVHAVVGVLSDDTDPMVTVMKLEKAPQETYADIGGLDTQIQEI-KESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLR-VVGSELIQKYLGDGPKLVRELFRVAEE--------HAPSIVFIDEIDAVGTKRDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFTIHTSRMT----LAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRE---------------RRMKVTNEDFKKSKESVLYRKKEGTPEGL..................................................................................................................................................................................................................................................... 437
9 -65.600[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  23  2.............................................................................SLEELEAMDQS--NPGEFLERVREKIRMLNSETRILQSRVNT-----IKHDISTKNASIAENMERIRLNKQLPYLVGNVVEVLDEHSGVVNASTRMSSYLPITGLIPNSELRPGDLVALHKDMKVGGMVLKSDAKPDETYEDIGGLERQIEE-LNEAIVLSLTHPERFEKLNIKPPKGVLMYGPPGTGKTLMARACASKTNATFLK-LAGPQLVQMYIGDGARLVRDAFALAKE--------RKPTIIFIDEIDAIGAKRDSDQTGDREVQRTMLELLNQLDGFSSSEEVKIIAATNRVDILDPALLRSGRLDRKIEFPLPNTLGRKRILQIHARKMS----VRDDVNFDELARSTEGFNGAQCKAVCVEAGMAALRK---------------EKTEISQNDFMDGIQEVLSRKKSK.......................................................................................................................................................................................................................................................... 396
10 -65.000[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  28  63...............................................................................................................................................QLLQEQGSYVGEVVKPMDKKKVLVKVHPIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEI-KEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIR-VSGSELVQKFIGEGSRMVRELFVMARE--------HAPSIIFMDEIDSIGSSRESGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMN----LTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRE---------------RRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK................................................................................................................................................................................................................................................. 405
11 -64.500[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  30  125...........................................................................................................................................................................VDPDSLKPGDLVGVNKDSYLILDTLPSEYDSRVKAMEVDEKPTEDYNDIGGLEKQIQEL-VEAIVLPMTHKERFEKLGVRPPKGVLLYGPPGTGKTLMARACAAQTNATFLK-LAGPQLVQMFIGDGAKLVRDAFQLAKE--------KAPCIIFIDEIDAIGTKRFDSEVSGDREQRTMLELLNQLDGFSSDERIKVIAATNRADILDPALMRSGRLDRKIEFPHPTEEARARILQIHSRKMN----VHPDVNFEELARSTDDFNGAQLKAVCVEAGMLALRR---------------DATEVNHEDFNEGIIQVQAKKKAS.......................................................................................................................................................................................................................................................... 419
12 -63.900[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  26  16...........................................................................AIVEDERTKALNSYRRKLAECRDIEQKLKDLRKKESEMTKQFDK-------------------SENDIKSLQSVGQIVGEVLKQLSEEKFIVKATNINKEELKQGTRVSLDMTTLTIMRQLPREVDPLVYKMSHEDPGNISYSDVGGLAEQIRE-LREVVELPLINPELFKRVGITPPKGCLLFGPPGTGKTLLARAVASQLDCNFLK-VVSSAIVDKYIGESARMIREMFNYARD--------HQPCIVFMDEIDAIGGRRSEGTSADREIQRTLMELLNQLDGFDSLGKVKVIMATNRPDTLDPALLRPGRLDRKIEIGLPNEQSRLEILKIHSNKIT----KHGEIDFEAVVKLSDGFSAADLRNVCTEAGMFAIRA---------------EREFVIDEDFMKAVRKVGDAKRLETKLDYKPV.................................................................................................................................................................................................................................................. 406
13 -63.700[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  22  2.................................................................................PDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQ---VEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEK-LREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIR-VIGSELVQKYVGEGARMVRELFEMART--------KKACLIFFDEIDAIGGARDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMS----VERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRA---------------RRKIATEKDFLEAVNKVIKSYAKFSAT....................................................................................................................................................................................................................................................... 426
14 -55.100[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  24  96................................................................................................................................................................................................................TEIVRDITLDDVVGQEEAKRKAKV--ILEYLRNPE---KFGKWAPKNVLFYGPPGTGKTMMAKALSNEAKTPFL-SVKSTKLIGEHVGDGARRVHELYERARQ--------LAPCIVFLDEFDAIALDRGYQEIRGD-VSEIVNALLTELDGTNSNEGICTIAATNRVELLDASI--RSRFEEEIEFRLPSYEERLEILRRNLEEFP----VPVKARLELVAAASEGFSGRDLVEKVIKASLHKAIAE--------------GKDKIETEDLLTAAEKVKMPSRQPPK........................................................................................................................................................................................................................................................ 348
15 -52.900[O] KOG0739 AAA+-type ATPase  ali follow..  22  71.................................................................................................................................................................KDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGA-KEALKEAVILPIKFPHLFTGK--TPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQ--------HKPSIIFIDEVDSLCGSRNENESEA--ARRIKTEFLVQMQGVNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEAARAQMFRLHLGSTPHN----TDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVCMSDMLRSLATTRPTVNADDLLKVKKFSED............................................................................................................................................................................................................................................... 432
16 -48.900[O] COG0465 ATP-dependent Zn proteases  ali follow..  23  133......................................................................................................................................................................................................SFGKSKARMLTEDQIKTSFADVAGCDEAKEEVSE--LVDYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFF-TISGSDFVEMFVGVGASRVRDMFEQAKK--------AAPCIIFIDEIDAVGRQRGAGGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVP----LDTDIDASVIARGTPGFSGADLANLVNEAALFAARG---------------NKRVVSMVEFEKAKDKIMMGAERRSMVMTEA--QKESTAYHEAGHAIIGRLV-PVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIYGPEKVSTSNDIKVATSIARNMVTQWGFSEKLGPLAKAKHMSDETARIIDQEVKLLVERNYQRARKLL----LENMDVLH---------------------SMKDALMKYETIDAPQIDDLMN................................................ 594
17 -48.600[O] KOG0740 AAA+-type ATPase  ali follow..  24  345.................................................................................................................................................................PKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFA-KATIKEIVVWPMLRPDIFTGL--GPPKGILLFGPPGTGKTLIGKCIASQSGATFF-SISASSLTSKWVGEGEKMVRALFAVARC--------QQPAVIFIDEIDSLLSQRGDGEHES--SRRIKTEFLVQLDGASSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASARKQIVINLMSK---EQCCLSEEEIEQIVQQSDAFSGADMTQLCRGASLGPIRSLQTADIATITPDQVRP---IAYIDFENAFRTVRPSVSPKDLELYEN................................................................................................................................................................................................................................................... 665
18 -44.300[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  22  311................................................................................................................................................................................................................KHSKNKIYFKDVAGCDEAKQEIME--FVHFLKNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESGVPFL-SISGSDFMEMFVGVGPSRVRHLFQEARQ--------AAPSIIFIDEIDAIGRARGRGLGGNDERESTLNQLLVEMDGFGTTAGVVVLAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFKIYLKKIKLDH--EPSYYSQRLAALTPGFAGADIANVCNEAALIAARH---------------EGATVTMAHFESAIDRVIGGLEKKNRVISKL--ERRTVAYHESGHAVVGWFL-PLLKVTIVPRGTAALGFAQYVPNENLLMTKEQLFDMTCMTLGGRAAEQVLIGKISTGAQNDLEKVTKMTYAQVAVYGFSDKVGLLS-SKPYSNKTGAIIDEEVRDWVAKAYERTVELV----EEHKVKVA---------------------EIAELLLEKEVLHQDDLLKILG................................................ 756
19 -43.600[O] KOG0743 AAA+-type ATPase  ali follow..  15  213..............................................................................................................................................................................................................................MDPNAKKKIIDDLERFLKRKEFYKRVGKAWKRGYLLYGPPGTGKSSLIAAMANYLKFDVF-------DLELSSIYDNGELKRVLLSTTNR----------SILVIEDIDCNAEVRDREAENQEDEQITLSGILNFIDGLWSSDERIIVFTTNHKERLDPALLRPGRMDVHINMSYCTGLGFRTLVSNYLGLDGLNHPLCEEIE-ALVDSTE--VTPAELAEEL-DVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKG-TFETLAMDPGAKKKIIDDMERFLKRRERVGKAWKRGYLLYGPPGTGKSSLIAAMANYLKFDVFDL-------ELSSIYENAQLKSILLST--TNRSILVIEDIDCSSAEVYEEGYYGRVTLSGLLNFVDGLSSFGDERIIVFTTNHKERLDPALLRGRMDMHINMSYCT--GLGFRTLVSNYLGLGGLNHPLCEEIEALIDSTEVTPAELAEELMQEDDTDVVLRGVVSFVENRKVEISKTK 955
20 -43.400[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  22  263......................................................................................................................................................................................................TTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQE--VVEFLKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFY-YASGSEFDEMFVGVGASRIRNLFREAKA--------NAPCVIFIDELDSVGGKRIESPMHPY-SRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIK----FDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGTTGASSTKIAKRMVTKFGMS-MTYSDTGKLSPETQSAIEQEIRILLRDSYERAKHIL--KEHKNLAEALLTYETLDAKEIQIVL..................................................................................................................... 708
21 -28.700[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  12  55......................................................................................................................................................................................................................FPLVRLAGVGRQTELLVRNTEQF----------IVGRPANNVLMSGARGTGKSSLVKALLHEYADKGLRLI---EVDKSDLIGLPYLLTLLKECPEK-----------FIVFCDDLSFESGDETYKALKTALDGGLSQRHLMPEYFDENAGTTGMRGEIHQKEAVEEKISLSDRFGLWLSFYPFDQNDYLAAVQNWLEDFGVPYDETAQMAALQWAQTRGSRSGRSAWQFACDWAGRLPKQR................................................................................................................................................................................................................................................................................................ 285
22 -21.000[K] COG1224 DNA helicase TIP49, TBP-interacting protein  ali follow..  13  1.........................................................................................................................................................................................MAGEIREITQTFERISAHSHIRGLGLDENLRAKDVADGL---QKRAREAAGVI---VRLIKS-GKMAGRGILMAGPPGTGKTAIAVAISKELGKDIPFVVSASEFYSAEMKKTEALIQAMRKAIGVRIRE------TRTVLEGEVVGLDYNMVPNPYNPTPESATLTLATKDEKRTFSVGGRLAMQFFTQGIEVGDVIVI--DKETGRIGKLGRSEKAKKKYDLGDDEV------VPSGKVEKEKEFTYVVTLHDLDEAIDNEVREAVDEQVKRLVEEGRAELVPGVLFIDETHLRAMESEMAPIIILASNRGFSRIRGTDIVAPHGIPLDLLD--RLLIITTEPYSREEIKTIIEIRAAESGIMLKLTDIGEKTSLRYAYEFAKMRNSGKVELEDVERAASIFADVSQSS---YLKKWEEKMLG...................................................................................................................................... 448
23 -20.400[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  16  166..............................................................................................................................................................................................................DLTARAESGKLDPVIGRDEEIRRAIQVLQRRTKNNP--------------VLIGEPGVGKTAIVEGLAQRINGEVPEGLKNKRVLSKYRGEFEERLKAVLNELSKEEGRV-------ILFIDEIHTMVGA-GKTDGAMDAGNLLKPSL--------ARGELHCVGATTLDEY-DAALER--RFQ-KVFVGEPTVEDTIAILRGLKERYEIHHHVQTDPAIVAAATLSHRYVSDKAIDLIDEAASSILEKQLAQAESAEGKEMTLLRYRVTDEEIAEVLSR-MMEGEKEKLLRMEEELHKRVIGQHEAIEAVSNAIRRSRAGLSDPN-RPIGSFLFLGPTGVGKTELCKTLANFLENAMVRIDMSEFM-GYVGYEEGGYLTE---AVRRRPYSVILLDEVE----------KAHHDVFNILLQVLDGRTVDFRNTVVIMTSNENSTLDYPSMKELVMSVVG-PEFINRIDETVVFENIREIATIQLARLIKRMESHGYQLHFTDACLDFIGEVGYDPVYGARPLKRAIQQ......... 821
24 -18.000[O] KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases  ali follow..  15  170..............................................................................................................................................................................................................DLTELARNGQLDPVIGREDEIRRTIRVLSRRTKNNP--------------VLIGEPGVGKTSIAEGLARRIDDDVPANLSNCKLLSKFRGEFEERIKSVLKEVEESETPI-------ILFVDEMHLLMGAGSGGEGGMDAANLLKPML--------ARGKLHCIGATTLAEY-DAAFER--RFQ-IILVKEPSIEDTISILRGLKEKYEVHHGVTSDRALVTAAHLASRYLTSSAIDLVDEAAAAVRVTRESQPEVLDNLERKLRQLRVEIRALEREKDEASKERLKAARKEAEQVEEEDVVGPDQINEIVARWTGIPVTRLKTTEKERLLNMLFCGPSGTGKTLLTKALASFMENAMIRIDMSEYM-GYVGHEAGGQLTEQ---LRRRPYSVILFDEIE----------KAAPEVLTVLLQVLDGQVVDAKNAVIIMTSN-REMVMNSIRGNRISSIVIFNRLR-RVDIRNIV-------ENRILEVQKRLQSNHRSIKIEVSDEAKDLLGS......................... 826
25 -16.600[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  10  149.........................................................................................................................................................................................................................................................LVQKRPILLAGPEGIGKKFLITQIAAKLGQQIIRIHLSDSTPKMLIGTYTSPKPGEFEWQPGVLTQAVITGK---ILFTNIE--------------APSEVLSVLLPLLEKIYAKGSFQMFATSS------MKTKILGQRLWQILDLTYQPDECVEVVSTLYPVLSIICPTLYSLCLRDFYKFIKRVAFL-QDAVFKEAIDMFGAFIPSRDGFDLVVRNVAIELNIPPEKALQLRYSIPVFQNLEHNINIGRCSLKKLSTIRSCSTNSYAFTSSSLGLLEQL-VQTNEPLLLVGETGTGKTTTIQLLAGLLGQKVTVINMSQMASTSARRFRWKTCLKIWKEACKLSKTVVLLDEINLA----------SLETLEPIGQLLS----SYESGILLSERGDITPITPH----RLFGCMNPSTDVGKRELTEIYVHSPDQNLDDLLSIIQKYIGSLCIGNEHVIREVAELYQVAKSLSLDGSLVDGAGQ......... 770
26 -16.100[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali follow..  13  336...........................................................................QEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRR--LSVAKKALDEGHYGMKDVKERIMEFIAVNLLR----------KSIGGLCFHGPPGVGKTSIAKSIATALNREYFRFSVGAEIKGTYVGAMPGKMIQCMKKVKTENP---------LVLIDEVDKI--------GGAGFHGDPASALLELLDPEQNLSRVLFICTANEISKIPGPLR--DRMEM-IDVSGYLAEEKVEIAHQHLQLRKDTSLATEQLKIEDSALEE-------IKHYCRESGVRNLQQHIERAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMG-GSALYIETVLKRPVDLTNDKDGSIETTG--------NLGDVMKESVRTALTVAFFDKAHIHIH--KDGPSAGVTLVSSLLSLALDRPVVQD----MAMTGEISLTGKVLPVGGIREKVIAARRVGAKRVF---------NRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQ......................... 971
27 -15.400[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  15  27.......................................................................................................................................................................................................................LLTEYVG-QPHVREQMEIFIQAAKQRGDALDH--------VLIFGPPGLGKTTLANIIANEMGVNLRTTSG-----------------PVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEILYPAMEDYQLPAARSIKLD----LPPFTLIGATTRAGSLTSPLR--DRFGIVQRLEFYQVADLEHIVSRSAKCLGLE---LTPEGAHQLARRSRG-TPRITNRLLRRVRDFA.................................................................................................................................................................................................................................................................................................... 234
28 -15.000[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  16  111.......................................................................................................................................................................................................................TLDDVVGQDHLLSPLLRSAVES-------------NRLPSIVFWGPPGTGKTSIAKSLINSSKDPSLYRFVSLSAVTSGVKD----VRDAVESAKRLNLEGRKRT---VLFMDEVHRFNKSQ--------------DTFLPVIED----GSILFIGATNPSFHLITPLLSRCRVLTLNPLKPNHVETLLRRAVDDSERGLPNSVEVDDSVIEFLANNCDGDARVALNALEISATMATTRAGTDAVVSIDDAKEALQCKHLAYDNLISAL--------------HKSMRGGDANAAIYWLARMLEGGEEPLYIARRLIRFASEDIGLADPSALTQAVACYQASHFLGMPECNVILAQCTAYLALAPKSIAVYRAIGAAQK...................................................................................................................................................... 449
29 -14.900[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  13  124.........................................................................................................................................................................................................................STILCREDEQIRIFE-----------VKGCIDQQKAGSLYICGCPGTGKSLSMEKVVQQVTQAGLPPVDTLSVNCTSLSKTTDIFSKILGEIKPGQKQESSSSRMMLIIADEMDYLITKD----------RGVLYDLFM-----LPFSRCILIGVANAIDLADRFLPK----PMVITFRAYSKDQILRILQERLRVLSYV--AFQPKALELCARKVAAASG-DMRCVCRSALEIL-EIETRGSTGPESQGPTPDDSVVRMDHMAAALSKTFKSPVVETIQSLPQ-----------------------------------------------QQIIICAAAKAFRGSKKDATVGELNKLYLEICKSWMISPAGITEFTN-----MCTVLNDQ----------------GILKVGQARRDKLKRVSL--RVDESDITFALQVNSLFILFFANP............................................................................ 507
30 -14.600[S] COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain  ali follow..  11  39.............................................................................................................................................................................................................................................................KHLLIEGPSGIGKTCVVFKVFEELQWSQGRDFT-------YVGCRDQNAEQIIDDFLKNAAAGNALSP-CVLVIDDFHLL---------SQAKRMEIGSTLKRLSD--AEPAKVILIGIPTAGVSLAYDLG--PRLG-SYALTRASDVEIDKLISEGEQALAVL-------DRDVLLAESAGNFW--AQYVCNKVCAIE-TQDDAKILTFDILGIRGRLMAELTQRYLPIARTFAKGKRWRPGGNKPYLEILLALCKIQDSVVTFDQLLQLVSERRRPGLKAVRTRISEVIFDPDHGTDLRKQIAFEADSGFSIEDPLFRIGFSFAGEARRLVELVNAEMKAEDIVTFYDFDQQ-----------AILLAMDLQDILGKVYGESCRYYLVFLDKN---FEKDVMTNGKRIDHIVPIVIDDEGASGTVGISNTIGRIDLKDVWAQIQKAGKISTDDVNTIKNRCVVPMLEKI.................... 517
31 -14.400[O] COG0466 ATP-dependent Lon protease, bacterial type  ali follow..  15  202..............................................................................................LMKQKENINFQMEMAKKVTDKISKSNREAMLREQLKMIQEELNGG-AASGEGGYRERIEKSTMPEEVKKKALSELKKLETGGPHNPESSVIRNYLDLMLDL--PWVTEEKKSIDIDEARRVLESNHNGLEKVKERIIQHLAVMKLK----------KEKQGLLLTGPPGTGKTSLGKSIADALGREYVRISLGAEIRGTYIGALPGRIIQGMRKAGTKNP---------VFILDEVDKL---------STSYAGDPASALLEVLDPEQNLSEVFFIATANSLASIPWPLL--DRMET-IEISGYTKNEKLAIAKDHLCILEEHGLDADKLKIEDEALKG-------IDKYTREAGVRGLKKQLARVSEKIVSGKTDLPYVVRADMLKEVLGK-------------------------EIIRQEEARKENVPGVVTGLAWTPVGGDILF--PGNGKLTLTGQLG-----DVMKESAQISLSLVRSRLASTENSFNFTAS-----------DVHIHVPSGATGPSAGVTLFTALTSLITGKAVDPK----LAMTGEITLSGAVLPVGGIKEKVLAAHRAGIKKVI-------KENERDLEDVPEEVRNELKFVPVETIEEVLKEAL.......................... 773
32 -13.800[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  16  25.......................................................................................................................................................................................................................TVEQYIGQQHILGPPLRRALEA-------------GHIHSMILWGPPGTGKTTLAEVAANYANAEVERV--------SAVTSGVKEIRAAIEKARENKL----SGRRTILFVDEVHRFNKSQ--------------DAFLPHIED----GTVTFIGATNPSFELNNALLSRARVYKLTSLNQQEILQALHAIADTERGLGKVAAVFADNVLDRLAELVNGDARMSLNYLELLYDMA--------------REDDQGRKQIDLPLLAEVAGEKVSRFDNKGDIWYKSIRGSDPDAALYWAARMISAGCDPLYIARRLLAIASEDVGNADPRGMQVALAAWDCFTRVGPAEGERAIAQAIVYLACAPKSNAVYTAWKQALS...................................................................................................................................................... 359
33 -13.500[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  15  394.........................................................................................................................................................................................................................KSLPCRSKEMEEIIKGSIS------------DQCLGRCMYIHGVPGTGKTISVLSVMKNLEAGSVSPYCFVEINGLKLASPENIYSVIYEGLAEGKKIGKENEKPCILLIDELDVLVTRNQS----------VLYNILD-----KPNSKLVVLGIANTMDLPEKLLPR-SRMGIQRLCFGP---NHRQLQEIISTRLEGINAFEKTA-IEFASRKVAAISG-DAREICRRAAEVADYRLKKSNISAKSQ-------LVIMADVEVAIQEMFQAPHIQVMKSVSKLS---------------------------------------------RIFLTAMVHELYKTGMAETSFDRVATTVSSICLTNGEAFPGWDILLK-----IGCDLGEC----------------RIVLCEPGEKHRLQKLQLFPSDDVAFALKDNKDLPWLANYL............................................................................... 771
34 -13.400[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  16  160.................................................................................................................................................................................................DLSRYNAIASRFAEERQQTLDFLKSGIATRNPHFNRMI-----------EQIEKVAIKSRAPILLNGPTGAGKSFLARRIRHQFSGAFVEVLRGDTAMSTLFGHV----KGAFTGARESREGLLRSANGGMLFLDEIGEL---------GADEQAMLLKAIFYPFGSDRQVSDFQLIAGTVR-----RQLVAEGKFREDLYFTLPGLRQRQEDIEPNLDYEVERHASLTGDSVRFNTEARRAWLARELSASVTRMATFATSGRITLDV........................................................................................................................................................................................................................................................................................... 435
35 -13.400[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  12  55........................................................................................................................................................................................................................FPGVVGYDDTVIPQLVNALLAR----------------NFILLGLRGQAKSRILRAITELLDPE-VPVIDGADLIGDVDPIKAARLGTSLGDTRSMHFGLLPRANRGIFAVNELADL-------------SPKVQVALFNILKGYPIRLDVMLVFSANPEDYIVTPLK--DRIGSEIRTHYPTDVQLGMDITAQEAVKEEGVVVPPFI-IEDIAFQAREDGRIDCANAERRSLVSGDAPVVRVTDVYAGLPAITGKMELEYEGELKGADNVAKDLIRKAAGAA..................................................................................................................................................................................................................................................... 387
36 -13.300[KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains  ali follow..  15  190.......................................................................................................................................................................................................................DSVEIIGNSGPMLAMKADIDVV------------APSQFNILIHGETGVGKELVARTIHQRSNRK-LVYVNCAAIPENLL-ESE-HVKGAFTGADRARMGKFALADGGTLFLDEIGEL---------PLSAQSKILRALIQPVGQDRVQTDVRILAATNR-----KKEVEAGRFRADLYIYVPPLRERKGDLSLLAGYFVEQARRKLGITQLKLHGDVYPWPGRELEHVINRAALKAKARQRGR-----------PVTTLKVEDLGELQGPRAAMVEPTAQDEPMLGEWIGELGLRDATDEFQRHLISETLTQADFNWAEAARRL-----QTDRANLTRLAKR.......................................................................................................................................................................................... 515
37 -13.300[T] COG0467 RecA-superfamily ATPases implicated in signal transduction  ali follow..  12  14.........................................................................................................................................................................................................................TGIPGFDFLSD--------------------GLPLGRATLIAGTAGSAKTIFASQFLVEG------IQRGENGVFVTFEEPPKALRKNMRGFGWDIQQWENEGKWVFVDASPQPGDRPIVSGEYDLGALIARIEHAVRISLDSLGA-----IFSHLSDSAQVRSDLFR-----------LASALRELGVTAIMTAERVEEYGEISRYGVEE-------FVADNVVIVRNVLADEKRRRTIEILKYRGTDHQKGEFPFTIINK--KGIVIIPLSAIELEQKSSDIRITSGSEELDRMCG----------------GFFRDSIILVSGATGTGKTLMVTEFGVANGERCLVFAFEESREQLIRNATGNHLIMMKDIIQEFKPNRVAVDSLSALERVST-----LKSFREFIIGLTSFIKQQEIGGLFTSTTPNGASITDAHISTITDSIILLEMYGEMRRGITVLKMRGSMHDKDIREFSIDHQGMHIGKPFRNVTGILAGTPMYTAQSEVERLSGLFDE......... 503
38 -12.900[L] KOG1968 Replication factor C, subunit RFC1 (large subunit)  ali follow..  11  298.................................................................................................................................................QHKIPAINEDGLFYLITHLPASGGTGAAAQAAQQKKEQEEKKILETVARMDDSNKKESQPSQIWTSKYA-SLKDICGNKGVVQKLLQDYHKNRKSNFNKPGPDGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLEL-RSKRLLDEQLFGVTDS-QSLAGYFGTKANPVDMAKSRLVLIMDEIDGM----------SSGDRGGVGQLNMIIKKSMI-----IICICN--DRAHPKLRPLDRTTFDLRFRRPDANS----MRSRIMSIAYREGLKLSPQVDQLVQGTQS----DMRQIINLL------STYKLSCSEMTPQNSQAVIKNSEKHIVMKPWDICSRYLH---------------------------------------------------GGMFHPSSKSTINDKLELYFN---DHEFSYLMVQENYLNTTPDRIRQEPPKMSHLKHLELISSAANSFSDSDLVDSMIHGP----------QQHWSLMPTHALMSCVRPASFVAGSGSRQIRFTNWLGN---NSKTNKLYRMLREIQVHMRLKVSANKLDLRQHYIPILYESLPVKLSTGHSDVVPEIIELMDEYYLNRE 807
39 -12.700[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  12  552...........................................................................................................................................................................................................................LVGHMDEQTKLYQ-----------VRQTIVLGEGNSVIIVGPRGSGKSVLVDDILSRAAQEINEKSYVVRLNGTYQTDDKLALREISRQLSIEAEDVMTTSAAVIFVLEEFDLFVQHS---------RQMLLYNLFDIAQ--SRKAPILIIGLTTRYDCSESLEKR-SRFSMVIPMRPPSSLS--EFEQILKSVLYVSDEGGKDQIITCWNQRVDELLSSHLHKLVQHHYFASRNLKLLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICAVRNFNSAYQEYRQLHQSSVINAAA--SGALAHSSRLWGRDVALEAWETLGSIGLIIPVHPSTNVSGALSRQCQLWQ-------------VDINVVSVGLREHRRLPSHYYRWLKEVI..................................................................................................................... 972
40 -12.500[R] COG0714 MoxR-like ATPases  ali follow..  18  1..............................................................................................................................................................................................................................MREQISVLTQNLSQTIVGKDEAIRLVLVALLSGALLEDVPGVGKTLLAKSLARSINGKFQRVQCTPDLLTDITGTN------IWNPSSREFEFLPGPAFANILLADEIN-----RATPRTQAALLEVMEEKQVTVDGETRLVPHPFFVIATQNPIEYQGTFPLPDRFALSLSLGYPSEAEELKMLQRQQNPEAIAVGDLESC-----------ISLEEVEALQKAVRQVKLTEDL............................................................................................................................................................................................................................................................................................... 220
41 -12.400[O] COG1219 ATP-dependent protease Clp, ATPase subunit  ali follow..  20  80...........................................................................................................................................................................................................................IG--QERAKKVLAVAVYNHYKRLNQRDKKD-LGKSNILMIGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGED---VENIIQKLLQKCDYDVEKAQMGIVYIDEIDKISRKSDNPSITRDVSEGVQQALLKLIEGVDTRNILFICGGAEPEDLVKFGLIPEGRLPVIATLDELDEAALMQILTEPKNALTKQDLEFRPDALKAVARKAERKTGA-------RGLRSILEGILLDTMYEIPSQQDVSKVVIDES.......................................................................................................................................................................................................................................................................... 401
42 -12.400[R] KOG2170 ATPase of the AAA+ superfamily  ali follow..  14  65..........................................................................................................................................................................................................................NYHTLDADIANLLQHLVKDVVVNSIKSHWYNENPRKPLVLHGYTGSGKNYVAEIIANNTFRLGLRSTFVQHIVATNDFPDKNKLEEYQVELRNRILTTVQKCQRSIFIFDEADKLPEQ-------------LLGAIKPFLDGVDFRRSIFILLSNKGGGEIARITKE-HLIDHFVPFLPLQREHVRSCVGAYLRKRGRGDLVSNVDFVERVLNSLQYFSGCK----VDAKTDLEMAKIRPLLSSVHFDDE.................................................................................................................................................................................................................................................................................... 355
43 -12.400[U] COG3267 Type II secretory pathway, component ExeA (predicted ATPase)  ali follow..  17  20........................................................................................................................................................................................................................................RYLYLSQRHQEAIVHLGLGDGGGAMLTGEVGTGKTTVARAILASLPGKTRAGFSDLELLEAICDEKKATLKKLTQVLHEFLLAEHAQGIQVLLMIDEAQHL---------APDVLEQL--RLLTNLEESHKLLKVLLIGQPELQEKLRLPQLRQ-RITGRYHLLPLNEEQTADYIRFRIEQASGNPELFNRKACQWIAEQTHGIP---INLVCDAALKQAYQAGEPTLSLARIKLACQE................................................................................................................................................................................................................................................................................. 264
44 -12.200[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  12  40.................................................................................................................................................................................................................................................PDLVSLEDIAEIPCLVLLGEPGVGKTHELEKLQRFTEET-----EYSKVLGLNLRTFTNLKEDLFRD--KTFSDWLEGHYHLHLFLDSLDEGLLN------VKSLAIGLVDEFKKPKYRSHINRLHLRLTCRTLPSILEEALKA-----AIYELAPLRRIDVINAVEAEGFSSDDFLKAINQRDIVPLAIK------ISLGFLLNESYLEGCKCLCEEVSKCRHALKETGNLDIDQR-LIVAARIAAVTIFANRFAVWIDVEQGQVPAEDVPRQKLCFGYEESNGREFEITQEVIQEVLLFSSRGLHREFFAAWYLTQRNIDLSKIKTLLYSSADSTPKLIPQLHETAVWLASMRDNVIIKTDPDVLLQTDPTDSELRATIVANLLMQYEEEK-NVRNYAKLKHSGLAEQLKVYICDSSKKEDIDIAIECNLSELQGDLAKLTLCPSQPISIRVNAARAISSIGDQSTRLKLKSLALNVLPEDEQDELKYALKALWPRQLTAE 573
45 -12.200[L] COG1484 DNA replication protein  ali follow..  14  89................................................................................................................................................................................................................................EGKPQAIKDAFECTKEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELCYVPVIYFPFVEGFTD--------LKNDFALLEAKLNRM---KQADVLFIDDLFK------PVNGKPRATDWQLEQMYSVLNYRYLNHKPILLSSELTIEGLEALGTKIYEMCSDYLVIIKGAAYELN................................................................................................................................................................................................................................................................................................................................................... 259
46 -12.200[L] COG0593 ATPase involved in DNA replication initiation  ali follow..  14  129...........................................................................................................................................................................................................................VEGKSNQLARAVGQKLA---------QAPGEPSANPFFLYGGTGLGKTHLLHAIGNGILADKVLYIHANNFMQHMVKAVRDNKMDQFKKFYR---------SLDALLVDDIQFFAEK-----------EKTQEEFFHIFNSLFETGRQIILTSDRYPKEIEKIEER-SRFGLTTAIEPPDLETRVAILL---KKAEEHNMNLPEEVAFFIAQRLRTLEGA-LNRVKAMQDFKGGDIDIDFVRDTLKDILALQERLVTIENIQKVVAEYYRIKVSD----------------------------------------------LKSKSRARSVTRPRQIAM--------------LAKELTNRSLPEIGRAFDRDHTT-----VLNACREVPKFREQDNSIQEDW-ANLIRTLSA................................................................................................................ 454
47 -12.200[LO] COG1474 Cdc6-related protein, AAA superfamily ATPase  ali follow..  13  40.........................................................................................................................................................................................................................DLLLHRNEQINSLAT-----------LVSALRGETPSNVLIYGKTGTGKTAVTRYVGKELERV-VVYINCANLARHFEEEVPMTGWPTDQVFMKFKEAIDARDQVIIIILDEIDKLIKKGDD----------VLYNLSRINTDLRK-AKVSMIGVSNDLKFTEFLDPR----EEELIFPPYDAEQISDILKQRAKMAYNDGVLGEMV-IPLCAAFAAQEHG-DARDLLRVSGEIAERENQPQVLEEHVRRAQEKIEIDRVVEVVRTLPTQSKLVLYSIILLRSRGREGKNVTTGEMYNVYRQLCHHI-RVTDLMSELDMLGIVNAVVVSKGRYGRTKEISLSVPVENTRKV-----------LEDYRLKPLVDFKTAVFNKM................................................................................................................................................. 418
48 -11.900[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  14  4........................................................................................................................................................................................LTSAMDIDVDEIQPRKPINKGKDVVGFGPPPQSKATPWVEKYRPQSLDDVAAHRDIIDTIDRLTNENKLPHLLLYGPPGTGKTSTILAVARKLYGP-ILELNASD------DRGIDVVRQQIQDFASTQSFSLGKSSVKLVLLDEADAMTKD-------------AQFALRRVIEKYTK-STRFALIGNHVNKIIPALQSRCTRFR--------APLDGVHMSQRLKHVIEAERLVVSDCGLAALVRLSNGDMRKALNIL----STHMASKEITEEESKQITEEDVYLCNPLPKDIEQISHWLLNKPFDECYKDVSEIKTRKGLAIVDIVKEITLFIF.............................................................................................................................................................................................................................. 317
49 -11.900[R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase  ali follow..  13  48..................................................................................................................................................................................................................................................RAVNDISFSIEPGLCVVGESGSGKSVTARSILQIIDSP--YITSGSIILN---KADGSSVDLAKLDPRGRAIRAVRGADIAMIFQEPMSSLSPVHTHLKMSKAQARAEAIELLRQV-EIPNPEKAL--GMRQRAMIAMALACKPQLLIADEPTTALDVTTQAEILDLISR-------LQKAHGMAVL------FITHDMGVVAQIADDVLVMHHGVVKEYGTVEQIFHKPQDPYTRMLIGSVLKLEQKAEIRLARPPLDQTAAPILEVKDLSMHFGEMKAL------SIKLLPGETLGIVGESGSGKTTMGRSIMRLYDPT-MLYRRADGSVVDLSKIEGKELKAA-----RRELRMVFQDPFGSLNPRMTVAQVIGEPLLERVCSLMEQVGQRQRIGIARAITLRPRIIVADEATSALDVSVRFQVLDLLMKLQDELGLAYIFISHDIGVIRYMCDRVGV---MYRGKLVEVGEAEKVCNAPDHPYTQALLSAIPR..... 564
50 -11.900[R] KOG2383 Predicted ATPase  ali follow..  13  99................................................................................................................................................................................................................................QCLQKLHEDLKGYNIEAEGLFSKL--KPPRGLYVYGDVGTGKTMVMDMFYAYVEMKRKKRVH----FHGFMLDVHKRIHRLKQSLPKRKPGFMAKEEACLLCFDEFDAM----------------ILKQLFENL-----KNGVVVVATSNRP---PEDLYKNG-LQRANFVPF------IAVLKEYCNTVQ----LDSGIDYRKRELPA---AGKLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQ-----------------------------------------------------------------------GRELLNKACGTVADCTFEELCERPL-----GASDYLELSKNFD--------TIFLRNIPQF-------TLANRTQGRRFITLIDNFYDLKVRIICSASTPISSL---------FLHQHHDSELEQSRILMD-----------DLGLSQDSAEGLSMFTGEEEIFAFQRTISR-LTEMQTEQYWNEGDRTK....... 480
51 -11.900[DL] KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component  ali follow..  32....................................................................................................................................................VSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQ------VLERQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPFQKDDFKGMFNTESSFHMFPYQSQGDDLRTDKKIILVEDLPNQFYRDSHT-------HEVLRKYVR-----IGRCPLIFIISDSLSGDNNQRLLFPKEI-SNISFNPVAPTIMMKFLNRIVTKNGGKITVPDKTSLELLCQGCSG----DIRSAINSLQFSSSKGENNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGK------------------------------VSLFLFRALGKILYCKRASLTELDSPRL-------------PSHLSEYERDTLLVEPEEVVEMSHMPGDLFNLIDDIVRASEFLSFADILSGDWNTRSLLREYSTSIATRGVMH---SNKARGYAHCQGGGSSFRPLHKPQWFL-------INKKYRENCLAAKALFPDFCLPALCLQTQLLPYLALLTIPMRNQAQISFIQDIGR.......... 586
52 -11.800[R] COG1204 Superfamily II helicase  ali follow..  1348...........................................................................................................................................................................................................................SSLNNPSFISLYPNFKFFNKIQTQVFNSV-YKTNDSVFIGAPNGSGKTVCAHHWSQEDYGTAVYIAPIQEIVDRRYGERSQDLKLIWDSLSKRWRSMRSIQKVDFYICDELQLLGGFYGP------LYEIVISRIRYMAVQLEKNIRVVGLSVS-----------------------VANARDLGEWLGTSPQCI----NFSPKDRPNPLTIHLQSFSITHFPSLMLAMSKPIYRSLKNDRKVAKQLAFDLVTFSMADEDEYLFSLMENEAFNKVEDAALQQSLKHGIAITSSNDQNIVQYL-----------RHGLIKVLI-------SRDVIYSL--KAKSNAVIVMGTQYYDGKEHDYPISELLQMLGFTASLSQVILMTTKKEYYKKFLNEPLPMESHLQVWLHDAFVS------EISTQTIESKQDAVDWLTWSYMYRRLVANPNDLSEARLITVDDEDDSCVALNLAMIASH-----YGITYITMQTFALSLSERTKMKGLLEIVTSAAEYEQLPIRKY 1899
53 -11.600[J] KOG0066 eIF2-interacting protein ABC50 (ABC superfamily)  ali follow..  13  355........................................................................................................................................................................................................................................ENFTISAKGNDLFVNANLLIAHGYGLVGPNGHGKTTLLRHIATDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADELEKQFVAGDLTVQ-TFAELKAIGAYSAEARARRGFSKEMQDRPTNKFSGLYLEPTLLML--TNHLDLLDNYLQG---WKKTLLIVSHDQKGNYSMFKKMYVQKRREMIKEYEKQEKRLRELKAHGQSKKAAEKKQKESLTRKQEKNKSKQQKQDEDEGPQELLARPKEYIVKFRFPEPSQLQPPILGVHNVTFA------PSQKPLFIKVDFGIDLTSRVA--------IVGPNGVGKSTFLKLLLGELEPQEGEQRKNHRLFGLVSHAHTIKMKDLLAELCLSAPDVLILDELD----------------IESIDALAEAINEYEGGVIIV--SHDERLIRET......................................................................................... 854
54 -11.600[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  16  14.......................................................................................................................................................................................................................KLQDVVGQEHITKTLQNALVQEKFSH-------------AYLFSGPRGTGKTSAAKIIAKAINCE-KGITSGSIVVMEIDAASNNGVDEI-RDIRDHVKFAPSEVRYKVYIIDEVHML-------------TTGAFNALLKTLE--EPPSHAIFILATTEPHKIPLTIIRCQRFDFK-RISNDALVGRMKEI------LTHEGIEAEDEALVLVARAAEG-GMRDSLSLLDQAISFADERVTVEDVLAITGAVSHEVLSAQKGETAEALQLV................................................................................................................................................................................................................................................................. 268
55 -11.500[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  11  50......................................................................................................................................................................................................................VPETRLREHRQQSEDLIAIARSGLENLFRQVAGQNLSDREGVTVEFLGDPLFGNSLRKAGLYLGSEWSEWRAGTCAVGACLETGEALTIHQTDHFDNTHTPLSCTAAP---LSAVLDISLLSSPILKASQNLALHLVSATVRRIELMAQARNQWVLRFSRSPEFLDVD-------EAAISI---DGLGRIAGMTHAGAKI--------ARSTGLDWRDPQQLIGEPVSRFFDIEVDNLSDLTRRRPTRERLVFARDGNAL-----FAHAIEPHSKVRAPLVSREQIPPALRRLGGDAPVIAALQAKAAKLART---------LPILIQGETGTGKEHLARAIGSGLEGPFVAINCAAIPEQLIESELFGYLPGAFTGASAADGGTLFLDEIGDM--------ALQSRLLRVLVLPVGGTAPRKVRIRIVSASHR---LQTLVSQGAFREDLTLPALRDRPDFDWVLEQLLKRHGDGELILSPAAHDWPGNIRELDNVIGVAAALAENGVVELGDLPDQLLANADTVGGN. 582
56 -11.500[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  193...............................................................................................................................................................................................................................................................TILLGDSGVGKTFLVKYNTGEFRLGSFSATVGIALTLFRISQPGGRLNQQPKKHSVASFRANCPCDNGLALLPSGSR-----------KPSISVATPTPLASGSPTRRESLVKPTWQHITPGQLPPKTLDKINIASDDSDDDGYPKRRPSVIVHQRQQSISQQPLLPEYMTSASIFRDHAPQTSQSQS--QSHHLPSGNGFMARLNSVRLASATEQQPLLDSGGGVSATAVARPPVAPAPVAPGPGSEGASATLCKNAGRALIRMISSSKAPEEEDEFDIMGKVIMLGDSGVGKTSLLSTVGIDFRNKVVVVDGTRVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKTTYDN---------IRAWLGEIREYAQEDVVIVLIG--NKADCSGS-------ERQVKREDGERLGRFMETSAKTGLNVELSFTAVARQLKSRGYEHGDDGKFNVHDFVRDNTKA..................... 656
57 -11.400[R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog  ali follow..  65..........................................................................................................................................................................................................................MIIGLPEALQEPTHR------YGPNGFALFGLPVPRGTGILGPNGIGKSTSVQILSGTLVPNF-GKGDWDTVLEHYAGTAHDYFKDVVDGKVKVSQKPQYVDLIPKAFKGKTSELLEKTDERGFLDELIDRLVERKISELSGGELQRVAIAACAARDAQFY---------------FDEIDIYQRINVARLVQEISKDRAVLVVEHDLAILDMLTDVIHIAY-GEPAGFGVITLPKSVRVGINQYLKGYLPEENIRIRPEAIRFEVHPPREDAQFQSMVSFNSFSKQ---------GFSLKATGGSLREGEV--------LGIVGPNGIGKSTFVKVLAGGTSYYEVEIANPLQLERIYESSGGELQRVAIAACLSQEADLYILDE----------SAHLDVEQRSMVTKVINRFAENNQKTAMV-VDHDIYMIDML......................................................................................... 516
58 -11.300[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  12  8............................................................................................................................................................................................................................................................VRTVAILGGESSGKSTLVNKLANIFNTTSAWEY-GRDYVFSHLGGDEIALQDKIALGHAQYIDFAVKYANKVAFIDTVTTQAFCKKYEGREHPFVQALIDEYRFDLDGLRSLGS-----RKEFQNLLVEMLEENN---EFVRVEEEDYDSRFLRCVELVREM.......................................................................................................................................................................................................................................................................................................................................... 182
59 -11.200[KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  12  18.........................................................................................................................................................................................................................................................................................................SVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKLANERCDAIIAAGSNGAYL------KSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGV-IPALVAFQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGA-GLITDLAEEAGMTGIFIYSAATVRQAFSDALDMT-------RMSLRHNTHDATRNALRTRYVLGDMLGQSPQMEQVRQTILLYARS---------AAVLIEGETGTGKELAAQAIQGKKSHPFVAVNCGAIAESLLEAELFGYEEGAFTGSRRGGRGTLFLDEIGEM------PLPLQTRLLRVLVTRVGGHQPVPVDVRVISATHC---LEEDMRQGQFRRDLFY-----RLSILRLQLPPLRERVADILPLAESLKVSLAALSAPFSAALRQGLQASETVLVHYDWPGNIRELR....... 452
60 -11.200[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  14  178...............................................................................................................................................................................................AVVMLRSTIRMGQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQARKL------------AMLSAPLLITGDTGTGKDLFAYACHQASPRS-YLALNCASIPEDAV-ESE-----LFGHAPEGKKGFFEQANGGSVLLDEIGEM---------SPRMQAKLLRFLFRRVGEDHEIHDVRVICATQKN----VELVQKGLFREDLYLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLSADLYGWPGRQLKNAIYRALTQLEGYELRPQD........................................................................................................................................................................................................................................................................................... 439
61 -11.200[T] COG2766 Putative Ser protein kinase  ali follow..  11  76.........................................................................................................................................................................................................................EEFYGMEDAIEQIVSYL--------KHAAQGLEEKKQILYLLGPVGGGKSSLAERLKSLMQRVPIYVLS-AQILEKEYGENNQDISALVGKVDIRKLEHHAQNDPGIMEFVEMFKA-------------PIKVLHPLLTATQE-----NGIILAHSNESEWFRNNKNNEAFLDRVYIVKVPRISEEIKIYEKLLNHSELAHAPCAPGTLETLSRFS-------LSRLKEPENSSIYSKMRVYDGESLKDTDPKAKSYQEYRDYAGVDEGMNGLSTRFAFKILSRVFNFDHAEVAANPVHLFYVLEQQIEREQFPQEQ--------------AERYLEFLKGYLIPKYAEFIGKEIQTAYLESYS-EYGQNIFDRYVTYADFWIQDQEYRDPDTGQLFDRESLNAELEKIEKPAGISNPKDFRNEIVNFVLRARANNNWTSYEKLRTVIEKKMFSNTEELLPVISFNAKTSTDEQKKHDDFVDGYTRKQVRLLCEWYLRVRKSS........................ 644
62 -11.100[O] COG4930 Predicted ATP-dependent Lon-type protease  ali follow..  11  239...............................................................................................................................................................................................................................................................VCELGPRGTGKSHVYKECS-----PNSLLVSG--------GQTTVA--NLFYNMASRQIGLVGMWD--VVAFDEVAGITFKDKDSGSFSRGRDSIEGKASMVFVGNINQSVETLVKTSHLLAPFPAAMIDTAFFDR-FHAYIPGWEIPKMRPEFFTNRYGLITDYLAEY-MREMRKRS---LGNNLNQRDVIAVRRTVSGLLKLLHPNGSYSKEDVRVCLTYA--MEARRRVKEQLKKLGGLEFFDVNFSYIDNETL--EEFFVSVPEQGGSELIPAGMPKPGVVVTQAESGMTGLYRFETQMTAGNGKHSVSGLGS-----STSAKEAIRVGFDYFKGNLSRVSATAKFSE-LHNTGPSTATSLAALIALCSVLLAKPVQEQMVVINPVQDLAASLQLAFDSGA--KKVLLP-MSSAVDIPTV--PAELFTKFQVSFYSEPVDAVYKALGVN.................................... 694
63 -11.100[L] COG0470 ATPase involved in DNA replication  ali follow..  14  23.......................................................................................................................................................................................................................TLDEVYGQNEVITTVRKFVDEGKLPH--------------LLFYGPPGTGKTSTIVALAREIYGK-VLELNASD------DRGIDVVRNQIKDFASTRQ---FSKGFKLIILDEADAMTNA-------------AQNALRRVIERYTK-NTRFCVLANYAHKLTPALLSRCTRFRFQ-PLPQEAIERRIANV------LVHEKLKLSPNAEKALIELSNG----------------DMRRVLNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSI..................................................................................................................................................................................................................................................... 251
64 -11.000[A] KOG0063 RNAse L inhibitor, ABC superfamily  ali follow..  73................................................................................................................................................................................................................................INLPKDLAKDTTHRYGANGFKLHRLPIPRPGLGLVGTNGIGKSTALKILAGKLKPNLLTHFRGSELQSYFIRVVEENLKTAIKPQHVDYIKEVVRGNLGKML-GLMEEICADME---------NQVLEREARQVSGGELQRFAIAAVFVKKADIYD---------EPSSYLDVRQRLKAAQVIRSLLRHDSYVIVVEHDLSLDYLSDFVCCLYGKPGAY-VREGINVFLAGFIPTENLRFRDESLTFRVSETTQENDGEVKSYARYKYPNMTKQLGDFKLEVM----------------------EGEFTDSQIIVMLGENGTGKTTFIRMLARPLQIEQLMDQVVKTLSG--GEKQ----RVAITLCLGKPADIYLIDE----------SAHLDSEQRITASKVIKRFILHAKKTAFI-VEHDFIMATYL......................................................................................... 532
65 -11.000[L] KOG2543 Origin recognition complex, subunit 5  ali follow..  10  18..........................................................................................................................................................................................................................................................RIISHVHIFGEDGSGRSEIVRQLLRKPENDWVCVLSLKLLFDSLASSRGDRAENFCDNLYKYVQWPDETNRKIVIFLDNAQAI----------TDYPPVPLQCLFDSYKAIQEITIRFVTSAPSCLNQYHINLSH-----VEFHIPAPSVETTKVLISRANPKINAQ-----HVACQSLFMACKSP--NILLSIISDAWLMYDERRTGD--------------KFDSTLAKECLNRSSGEKLGNVVGENLAKENENSFDAMPLAMRYLKILNRKYVVLPEIPVNFYFRYLL----------IAAYCASNNPHQ----SDCRFFVKNHGREKRSEKKELRLEENRLAKDL----DLQRII-----------CIYETLLKINESTITGFDLKSVIASLDSMGLV-----------------SVTNRSNLDIPKIKCLISLESALKISRS-------LNLELRNYLEHAT........................... 418
66 -11.000[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  12  40................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKYRPVKLNEIVGNEDTVSRLEVFAR----------EGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLEL--NASNDRGIDVVRNKIKMFAQQKVTIIILDEADSM----------TDGAQQALRRTMEIYSKTTR--FALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIKERVPYTDDGLEAIIFTAQG-----DMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVK.. 264
67 -11.000[P] COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA  ali follow..  11  1..............................................................................................................................................................................................................................MGYKMSSLQILQGTFRLSDTKTLQLPQLTLNAGWAFVGSNGSGKSALARALAGELPLLK-RQSQFSHITRLSFEQLQKLVSDEWQRNNTDMLGPGEDDTGRTTAEIIQDEVKDAPRCMQLAQQFGTPLLDRRFKYLSTGETRKTLLCQALMSEPDLLDEPFD--------------DVASRQQLAER----------------LASLHQSGITLV-DEIPEFVQFAGVLADCTLAETGAKEELLQQALVAQLAHSEQLEVQLPEPDEPSARHALPANEPRIVLNNGVVSYNDRPILNNLSWQVNPGEH--------WQIVGPNGAGKSTLLSLITGDHPQGYLTLFGRRRGSGETIWDIKKHIGYVSSSLHLDYRVSTTVRNVQQWLDILGIDKRTADAPFHSL-----SWGQQRLALIVRALVKHPTLL--------LDEPLQGLDPLNRQLIRRFVDVLISEGETQLLFVSHHAEDAPACITHRLEFV................................ 480
68 -10.900[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  13  235......................................................................................................................................................................................IGQLHNIQGRQLFLMAFHQSHTSFSVANAPDEPHIEQLVGECRVMRQLKRLISRI------------APSPSSVMVVGESGTGKEVVARAISGRRNKPFIAILLESELFGAFTGASANGKTGLIQAANT-----------GTLFLDEIGDM---------PLMLQAKLLRAIILPIGASSPIQDIRIISATNQAQFIAEGKFREDLFYRVIPITLPPLRERQEDIELLVHYFLHLHTRRLGSVYPGIAPDVHRWPGRELSNLMEYLVNVVPSGEVIDSTLLPPNLLNNGTTEQSDVTEVTEAHLSLDDAGGTALEEMEK--------------------QMIREALSRHNSKKQVADEL----GIGIATLYRKIKK.......................................................................................................................................................................................... 586
69 -10.900[F] KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response  ali follow..  17  4.............................................................................................................................................................................................................................................................PNILLTGTPGVGKTTLGKELASKSGLKY---INVGDLA------REEQLYDGYDEEYDCP-------------ILDEDRVVDELDNQMREGGV---IVDYHGCDFFPERWFHIVFVLRTD--TNVLYERLETRGYNEKKL-----TDNIQCEIFQVLYEEATASYKEEIVHQLPSNKPE-------ELENNVDQI-LKWIEQWIKDHNS.......................................................................................................................................................................................................................................................................................... 172
70 -10.900[S] COG4983 Uncharacterized conserved protein  ali follow..  10  475...............................................................................................................................................................................................................................IEAERVRFEQWLAHIVQRPEELPQSAY-----LFITEETGIGRNWLSSVLVRVLRGYVAAGIDIQEMLGTFNGRLSRKL---------------------LAVVDEAKAGMQGYGRWSHSEKLKSMINPEMRRIGLEFVEWNCCRWLFFSNNWDAL--PFDASDR--RFNVVANPTHRQSPDYYERIYSQIANPDFISSGFKPGAIPDMNE--AKRKALGAMASDLDNLLAAFRDEWPGPLAERSDVINYLPGEKTINKLIEQA................................................................................................................................................................................................................................................................. 729
71 -10.600[F] COG1618 Predicted nucleotide kinase  ali follow..  13  8..........................................................................................................................................................................................................................................................KTMLRIAVTGSPGVGKSTVVAKTAEKLAEKPGFKIGG--IRTAEIRKEGHREGFSIRDLATGKTGVRNALACDLVVIDEI-------GPMELISQSFVSAVEEVLE--------SDKPVLAVL-HHSSRHPLAQRFRKGFEVLTV---DKGNRDELPEKITNRFLR........................................................................................................................................................................................................................................................................................................................................ 181
72 -10.300[R] COG4639 Predicted kinase  ali follow..  15  2......................................................................................................................................................................................................................................................KITIPELSLVVLIGASGAGKSTFARKHFQPF-----EVISSDFCRGLVSNDSQSASRDAFDVLHYITTKRLAAGKLTVIVFDLPEELCHERNQQRSDRQFGSHVVRRHTQMLRRSEGFRYVYTLKSPEEIANVAIELQP....................................................................................................................................................................................................................................................................................................................................................................... 170
73 -10.200[L] KOG1803 DNA helicase  ali follow..  10  232...........................................................................................................................................................................................................................IGNLPETLNPSQVAAVSAAMNTQRNL----------LCIQGPPGTGKTVIAEIVHQLMKKKKKVLVCAP---------THVAVRNAMDATTGRMIEEMPEEKAEQQLCLLANTKDEFQNHKSASKLIRNSIFRSIFYPKL---------AVFSTLGTSSIQKLPEYHWNADVMIVDEAAQCTEPATWVPVLTTPSCKKLILVGD--VLSDKAMKGNFKLSLMEKLAEEFSSNNINILLNEQYRMNKKIMNWSNEVFYENQLTAH-------------------------------STVSDITLRDICPNLPEDHVLNNPIMMINMENVKDRSHEEFESH----------------SFTNTDELNLVTEYVNRLVVDL---INPKAIAVISPYYAQIEKLRRSIPFRVVNTVDAFQGHERQVVIFCLVRDNDEGQIGFLNE--TRRLNVAVTRARRQFVLIGNGRMMKGNKHLLKLYKHLQSEKVIFGPSILETFNDLEEAALPRSD................... 691
74 -10.200[F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)  ali follow..  22  3...............................................................................................................................................................................................................................................................IAITGTPGVGKTTVAKLLAKKLNYEYVSLALEKGCGRRVNDEVEVEIDELAYFIERELKGKNAPVDLVVVLRAHPKLIGERRERGYDREKIGENVEAELVDAVEAIEEHENVIEVDTTNKPEDVVEEIVS....................................................................................................................................................................................................................................................................................................................................................................... 149
75 -10.000[S] COG4185 Uncharacterized protein conserved in bacteria  ali follow..  12  10..........................................................................................................................................................................................................................................................EQPVFLIVAGPNGSGKSSVYANADLELEGRSVWIVNPDLLAGRISEVENKPLPEANLVAVQRIEAW-------------IQSSISVHKTIGVETVLSTDKYRRLVEAAEAVGFAIWLFYTVLDSPERSIERIKLR-GH-------DVPADK----VRARYARSLDQLPWFLERADRAWIWDNSG...................................................................................................................................................................................................................................................................................................................... 172

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.