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Query: [G] KOG0747 Putative NAD+-dependent epimerases, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASYTPKNILITGAAGFIASHVANRLIRSYPDYKIVVLDKLDYCSNLKNLNPSKHSPNFKFVKGDIASADLVNHLLITEGIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRFIHVSTDEVYGETDEDALVGNHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNNVYGPNQFPEKLIPKFILLAMRGQVLPIHGDGSNVRSYLYCEDVAEAFEVVLHKGEVGHVYNIGTKKERRVNDVAKDICKLFNMDPEANIKFVDNRPFNDQRYFLDDQKLKKLGWSERTTWEEGLKKTMDWYTQNPEWWGDVSGALLPHPRMLMMPGGRHFDGSEDNSLAATLSEKPSQTHMVVPSQRSNGTPQKPSLKFLIYGKTGWIGGLLGKICDKQGIAYEYGKGRLEDRSSLLQDIQSVKPTHVFNSAGVTGRPNVDWCESHKTETIRANVAGTLTLADVCREHGLLMMNFATGCIFEYDDKHPEGSGIGFKEEDTPNFTGSFYSKTKAMVEELLKEYDNVCTLRVRMPISSDLNNPRNFITKISRYNKVVNIPNSMTVLDELLPISIEMAKRNLKGIWNFTNPGVVSHNEILEMYRDYINPEFKWANFTLEEQAKVIVAPRSNNEMDASKLKKEFPELLSIKESLIKYAYGPNKKTLast
1 -166.000[G] KOG0747 Putative NAD+-dependent epimerases  ali  100  1MASYTPKNILITGAAGFIASHVANRLIRSYPDYKIVVLDKLDYCSNLKNLNPSKHSPNFKFVKGDIASADLVNHLLITEGIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRFIHVSTDEVYGETDEDALVGNHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNNVYGPNQFPEKLIPKFILLAMRGQVLPIHGDGSNVRSYLYCEDVAEAFEVVLHKGEVGHVYNIGTKKERRVNDVAKDICKLFNMDPEANIKFVDNRPFNDQRYFLDDQKLKKLGWSERTTWEEGLKKTMDWYTQNPEWWGDVSGALLPHPRMLMMPGGRHFDGSEDNSLAATLSEKPSQTHMVVPSQRSNGTPQKPSLKFLIYGKTGWIGGLLGKICDKQGIAYEYGKGRLEDRSSLLQDIQSVKPTHVFNSAGVTGRPNVDWCESHKTETIRANVAGTLTLADVCREHGLLMMNFATGCIFEYDDKHPEGSGIGFKEEDTPNFTGSFYSKTKAMVEELLKEYDNVCTLRVRMPISSDLNNPRNFITKISRYNKVVNIPNSMTVLDELLPISIEMAKRNLKGIWNFTNPGVVSHNEILEMYRDYINPEFKWANFTLEEQAKVIVAPRSNNEMDASKLKKEFPELLSIKESLIKYAYGPNKKT 669
2 -79.900[M] COG1088 dTDP-D-glucose 4,6-dehydratase  ali follow..  41  2......RKILITGGAGFIGSALVRYIINETSD-AVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDICDRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAKKSAFRFHHISTDEVYGDLHSTD-DFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLPTLITNCSNNYGPYHFPEKLIPLMILNALAGKPLPVYGNGQQIRDWLYVEDHARALYCVATTGKVGETYNIGGHNERKNLDVVETICELLEEHYRDLITFVADRPGHDLRYAIDASKIARLGWLPQETFESGMRKTVQWYLANESWRKQVQDGSYQGERL.......................................................................................................................................................................................................................................................................................................................................... 351
3 -62.100[MG] COG0451 Nucleoside-diphosphate-sugar epimerases  ali follow..  24  2.......RYLVTGTAGFIGFYVAKRLLDA--GHFVTGFDGMTYDVSLKRHAILARSNGFRAEIGMLEDTDALKRAAEAAEPEIIIHLAAQAGVRYSLENPRAYIDSNLIGSFNMLELARSLK-VKHLMLASTSSIYGANEKIPFA--ESDKADEPMTLYAATKKSMELMAHSYAHLHKLPTTAFRFFTVYGPWGRPDMAPIKFVDAVSNGQPIDIYGQGNMSRDFTYIDDLVEGIVRLSAHHAPFRVVNIGGGQPVELMHFVETIEKAVGKPAI--RNMLPMQQGDVPRTFASPDLLRATGYVPQTPVEEGIKALVAWYRGINGNLTE..................................................................................................................................................................................................................................................................................................................................................... 339
4 -61.500[M] COG1089 GDP-D-mannose dehydratase  ali follow..  21  2.....TKVALITGVTGQDGSYLAEFLLDK--GYEVHGIKRRASSFNTERIDHIYQNPNFHLHYGDLTDSSNLTRILKEVQPDEVYNLAAMSHVAVSFESPEYTADVDAIGTLRLLEAIRFLGNKTRFYQASTSELYGLVQEIPQ---KESTPFYPRSPYAVAKLYAYWITVNYRESYGIYACNGILFNHESPRRGETKITRGLANIAQGLESCLYLGNMDSLRDWGHAKDYVRMQWLMLQQEQ-PEDFVIATGVQYSVRQFVEMAAAQLGIKMSFVGKGIEERPAEVDTLLGDPSKANLLGWRPEITLAEMISEMVAKDLEAAKKHSLLKSH................................................................................................................................................................................................................................................................................................................................................. 363
5 -58.600[GM] KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase  ali follow..  27  29....SNMRILVTGGAGFIGSHLVDKLMQN-EKNEVIVADNYF-TGSKDNLKKWIGHPRFELIRHDVTEPLF-------VEVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKRVGA--RILLTSTSEVYGDPLVHPQTESYNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARIFNTYGPRMNIDRVVSNFIAQALRGEALTVQKPGTQTRSFCYVSDMVEGLMRLMEGDQ-TGPINIGNPGEFTMVELAETVKELIKPDVE--IKMVENTPDDPRQRKPDISKAKELGWEPKVKLREGLPLMEEDFRLR........................................................................................................................................................................................................................................................................................................................................................... 337
6 -53.600[GO] KOG1431 GDP-L-fucose synthetase  ali follow..  18  1MGEPGSMRILVTGGSGLVGKAIQKVVAD---GAGLPGEDWVFVSSK----------------DADLTDTAQTRALFEKVQPTHVIHLAAMGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEVG-ARKVVSCLSTCIFPDKTTYPIDETMNGPPHNSNFGYSYAKRMIDVQNRAYFQQYGCTFTAVIPTNVFGPHDNFNGLIHKVHLAKSSGSALTVWGTGNPRRQFIYSLDLAQLFIWVLREEVEPIILSVGEEDEVSIKEAAEAVVEAMDFHGE--VTFDTTKSDGQFKKTASNSKLRTLPDFRFTPFKQAVKETCAWFTDNYE......................................................................................................................................................................................................................................................................................................................................................... 317
7 -50.100[M] COG1087 UDP-glucose 4-epimerase  ali follow..  28  2.......TILVTGGAGYIGSHTCVQLIEA--GHEVVVVDNFD-NSHPEALHRIEKGRAPRREPGDIRDRALMEQMIKRHKCTAVIHFAGLKAVGESSEKPLLYYDCNVLGTLRLLQAMEATG-VKKLVFSSSATVYGDPDKLPI---TEDQPLSATNPYGRTKLVIEDMLRDYNSDNSWAIAILRYFNPVGAHESPNNLMPIIAQVATRREKLNIWGDGTGVRDYIHVNDLAAGHLKALKKLDKPFAVNLGTGQGYSVLDVIKAFEHVSNREIK--YEIAPRRPGDVAECYADPGFAKKLGWSAEKNLREMCQDMWNWQSKNPNGYE...................................................................................................................................................................................................................................................................................................................................................... 335
8 -50.100[M] KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase  ali follow..  24  89QREEGVTHVLVTGGAGYIGSHAALRLLRD--SYRVTIVDNLS-RGNLGAVKTLQQTGRLQFIYADLGDPLAVEKIFSENAFDAVMHFAAVAYVGESTLYPLKYYHNITSNTLGVLEAMARHK-VKKLIYSSTCATYGEPEKMPI---TEDTPQVPINPYGKAKKMAEDMILDFSKNSDMAVMILRYFNVIGSDPEQGRISGACFDAARGFIPGLQVSDGTCIRDYIDVTDLVDAHVKALEQPRKVGIYNVGTGKGRSVKEFVEACKKATGVEIK--VDFLPRRPGDYAEVYSDPTKILKLNWTARFTLQDSLQVAWRWQKIHPHGYNS..................................................................................................................................................................................................................................................................................................................................................... 435
9 -39.000[IE] KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases  ali follow..  15  1MGNKSGEVLLVTGGSGFLGQHLIKQLLERKEELGIKEIRSLDIVPYKNNIGHEETSLLRTYVADIGGDLKALSPIFN--GVDGVFHCAASVKIEYP-PNYEELERVNVNGTLAVVDLCIQNN-VKRLVYTSCTSVCFVPFKGRSTFSAEQDNQFLIPGYASSKLRAENIVLNSNGA-YLATSAMRAPLTYGECD--SHFITEIFDFLSTGWVFPRIAGVGGKQQLVYAGNVAWGHICAYKALKVGLPVFVTDDTGINDVSLLEVVVRVAYPYTKYRLRYSLRAIASSSMLMYNRLRASIMDYMPLFDPDASAERSAKWYATW........................................................................................................................................................................................................................................................................................................................................................... 384
10 -32.700[R] KOG4288 Predicted oxidoreductase  ali follow..  15  2.......KIVVLGGSGFLGHNICKLAIAK--GYEVVSVSR---RGAGGLHNKEPWMDDVEWETLDAKDPNSLLPVLR--DASAVVNSVGILMENNYKKNKVTFEAINRDLAIETAKIAAKAN-VPVYCYVSA----------------HAAAPGLDPRYIKTKREAEREIS---KISNLRSIFLRPGFMYNFNDRPFTSLFTVSSSINRATSGALNFLGTASAEPLPSEEVALAALEAISDPSVKGPVEISELKSMAHKFKQKSL.................................................................................................................................................................................................................................................................................................................................................................................................................... 276
11 -32.100[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  16  31.LANLPPLVTVFGGSGFVGRHVVRMLAKRGYRIRVAVRRP----DLAGFLQPLGNVGQISFAQANLRYRDSIIKAVE--DADHVVNCVGILA----ESGRNTFDAVQEFGAKAIAEAARDTG--ATLTHISAIGADANSQ----------------TGYGRTKGRAEAAIHS-----LPGAVILRPSIIFGPE---DDFFNKFAKMARNLPFLPLIGGGKTKFQPVYVEDVAEAVARSVDGKLKGAIYELGGPDVMTFRDCLEAVLAATYRETPDQVTMLKKDNVVSAEAEKKGLTLEGIGITP-VRVASVLPSYMVQYRQHGQF........................................................................................................................................................................................................................................................................................................................................................ 347
12 -31.000[C] KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit  ali follow..  14  63RSSVSGIVATVFGATGFLGRYLVQQLAKM--GSQVLVPFR-GSEDSPRHLKLMGDLGQVVPMKFDPRDEDSIKAVMA--KANVVINLIGREY----ETRNFSFEDANHHIAEKLALVCEHGG-IMRYIQVSCLGASVSSP----------------SRMLRAKAAAEEAVLN----ALPEATIMRPATMIGTE---DRILNPWS-MFVKKYGFLPLIGGGTTKYPVYVVDVAAAIVAALKDDGSGKTYELGGPDVFTTHELAEIMYDMIREWPRY------NALTTDTLVSDNALKFQDLDLVP-HKLKGYPVEFLIQYRKGGPNFGSTVSEKIPTD............................................................................................................................................................................................................................................................................................................................................ 397
13 -30.800[M] COG1091 dTDP-4-dehydrorhamnose reductase  ali follow..  15  1................................................................................................................................................................................................................................................................................................................................................................................................MRLAVTGRNGQVVSALQALAGADLEIVTL-ELDLVRPENVLQALREAKPDVVVSAAAYT---AVDKAESEPDIAFAVNRDGAKAVAQAAKELGVPVIHLSTDYVFDGSKATAY-------VESDPTGPTSIYGRSKLKGERAVSEATDNY----VVLRTAWVYSENNFVKTMLKRDEINVVADQFTSATDIAAAVVAIARKSLRGIFHLSGTGETTWANFAKQIFAFSAENKSMIVNDITTKQYPTPAPRANSRLNCRKLEEIYGLKPSWQTSTREVVTALAQTK 293
14 -27.200[V] KOG1502 Flavonol reductase/cinnamoyl-CoA reductase  ali follow..  17  3.NSGEGKVVCVTGASGYIASWLVKFLLSRGYTVKASVRDPSDPKKTQHLVSLEGAKERLHLFKADLLEQGSFDSAID--GCHGVFHTASPFFND-AKDPQAELIDPAVKGTLNVLNSCAKASSVKRVVVTSSAVGYNGKPRTPDVTVDETW--ASKMWYVLSKTLAEDAAWKLAKEKGLDIVTINPAMVIGPLLQPTNTSAAAILNLINGAKTF-----NLSFGWVNVKDVANAHIQAFEVPSANGRY-CLVERVVHHSEIVNILRELYPN------ERCVDENPYVPTYQVSKDKTRSLGIDYI-PLKVSIKETVESLKEK........................................................................................................................................................................................................................................................................................................................................................... 321
15 -24.200[MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases  ali follow..  21  277.KNITEKSVMVTGAGGSIGSELCRQILAQKPK-TLVLFELNEYN--QAIKQNLKLNTKIVAALGSVQRENRVKKLMQAHQVETVYHAAAYKHVPLVEDNVIEGIRNNVFGTLACANAAIEAG-VKNFTLISTDKA-----------------VRPTNIMGASKRMAELVLQALADK-TTIFTMVRFGNVLGSS----SVVPLFKKQIRAGGPVTV-THPDIIRYFMLIPEAAQLVIQAGAMSHNGQVFVLDMGEPVKIVDLAKRMIHLMGMKEFCD----GRSDEGDI-------EIKFTGLRPGEKLYEEL..................................................................................................................................................................................................................................................................................................................................................................... 560
16 -21.000[R] COG1090 Predicted nucleoside-diphosphate sugar epimerase  ali follow..  15  31....TLMKIILTGATGFVGCSLVPLLHQQ--GHELTLLVR---VSKAQRLFAPGSFPQLKAIAYEATKSGDWQKVVD--GQDAVINLAGEPISERTEAYKAEIFDSRKLGTEKLVEAIAKADRKPQMISGSAIGYYGTSETATF---TESSK--PGDDFLAEVCQAWENAAHQVEQLGVRLVVFRIGIVLGADGGALAKMLPPFKLFAGGP----LGSGEQWFSWIDRRDLIALIDKALTDSTLRGTYNATAPNPVKMKEFCHTLGKVLAPDIALELLLGEGAKLVLEGQEVLPGAISKTDFQFQADLETSLRQILG................................................................................................................................................................................................................................................................................................................................................................ 338
17 -19.900[Q] COG3320 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes  ali follow..  14  7....EVRTVLLTGATGFLGRYLALKWLERLVEGKVIALVRAKGDPKLLAHYQELATDHLEVIAGDKGEVDL------ADTVDLIVDPAALVNHVLPYS---ELFGPNTLGTAELIRIA-LTSKQKPYIYVSTIGVGNQIEPAKFTEDSDIRVISPANGYGNSKWAGEVLLREAHDLCGLPVTVFRCDMILADTSNVPDMFTRMMLSLAATGIAPGSNRQRAHYDGLPVEFIAEAISTLLHDRDGFTTYHVMNPHDIGMDEFVDW--------------------------------LIDAGCP------QRINDYDEWLRRFEISLRALPERQRHSSLLPLLHNYQKPEKPLHGSLAPTIRFRTAVQNANIGQDKDIPHISPAIIAKYVS-LLGLV................................................................................................................................................................................................................................................................................. 407
18 -19.500[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  10  212LTTLSWINALYCNGNLLYPSSEAERLAWNVYYALRAGCERLIILPNLLVLEECFPACKLVAAGGEMVPANMYHTCKRVLPNATIYPQYGTTESG-TEDNEAVPEKIGCEGFVCVVTDVQSEPYVGDFINYDGQPAVADKGKLGITIKGRLGRRVKRNGVFFDLKYFDQVVVGLKEVKDAFSFFIFNRFVLVNKELRDHHLFSSCFPL---ADIPRNAAGKVDL---------KSIETYASKCLSVEDQRLPVLLNPVAIEISKIASKILQNPSLEGKD----------------APLYSCG--------DSIHSVRFFHAIQSHFHLEGPIRYNMNSNCTPNSIASIIQKKSYNVSSITYELLNEDACALSRTIPKLSILPTNGQYFLLTGATGYFGRRFLEYLVKLNISVVCLVRESSDEAAKERLISVENVSRIYHMAAEVH-------MKSYQELRPANVLGTKTVLELSVMGPKALYFISGGGQQEVEL-----------DDDTQSAKASGYALSKYVAELLCRKISDLGHPLIYVIRPGFIIASRDFFWRFVATDESQSLVFHISTTDALCMTLTQILEKEADAYAPLLAYDKFDGDEFACICESMKNVKLD.................................................... 910
19 -18.600[I] KOG1221 Acyl-CoA reductase  ali follow..  23  19...YANKTILITGATGFMGKVLVEKLLRSCADLNVIYLVRKEQYFKCVIFGKLLEKDKVRVVKGDLLEPDL-DTNTLASNVEVVFHCAANVRFDQPLRPM---VMMNVVGTLKVLRLAEKMSQLQALVHVST--SYCQCNESVLEERAYPAPQNPFNTYAYSKALSEDLICRYNN--KLPIIITRPSIVTAAIHEP-NGPTGLMIGAARGVIRSMHCNPDYASTVIPVDKAINGMILCGNKQTGVEFCNLCISSK.............................................................................................................................................................................................................................................................................................................................................................................................................................. 327
20 -17.600[I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes  ali follow..  11  6..SFKDRVVVITGAGGGLGKVYALAYASR--GAKVVVNDSKAADLVVDEIKKAGGIAVANYDSVNENGEKIIETAIKEFRVDVLINNAGVSFAKMTEREFASVVDVHLTGGYKLSRAAQKFGRI--INTASPAGLFGNFGQAN---------------YSAAKMGLVGLAETLAKEGAKYNINVNSIAPLARSRMTENVLPPHILKQLG-------------------EKIVPLVLYLTHESVSNSIFELAA----------------------------------------------------------GFFGQLRWERSSGQIFNPDPKTYTPEAILNKWKEITDYRDKPFNKTQHPYQLSDYAKKLPPNEQGSVKIKSLCNKVVVVTGAGGGLGKSHAIWFARYGAKVVVNDDSHDVVTEAPLIIQTARVDILVNNAGILRDKSFKMKDEEWFAVLKVHLFSTFSLSKAVQKSGFIINTTSTSGIYGNFGQ-------------------ANYAAAKAAILGFSKTIAAKRGIIV------NVIAPTAMTKTIFSEKELSNHFD-----SQVSPLVVLLASEEIGQLFEVGGGETIEPEEIKENWNHITDFS...................................................... 590
21 -16.500[Q] KOG1204 Predicted dehydrogenase  ali follow..  16  2.....GKVILITGASRGIGLQLVKTVIEE--DDECIVYGVARTEAGLQSLQREYGADKFVYRVLDITDRSRMEALVEE-KLDGIVANAGQSNSEHDIKQWERLFDVNFFSIVSLVALCKSSPFVGNIVFVSSGASVKPYNG---------------SAYGCSKAALNHFAMDIASEEP-KVRAVCIAPGVVDTQMQKDIRETLGPQGMTPKALERFTQLYKTSSLLDPKVPAAVLAQLVLKGINGQYLRYNDE................................................................................................................................................................................................................................................................................................................................................................................................................................ 256
22 -14.300[R] KOG1611 Predicted short chain-type dehydrogenase  ali follow..  10  2....SPKSVVVTGSNRGLGFGLVQQFLKDPNVQHVIATAR---VDKATALKGICD-PRLHILQLSLGSDESIANFAEKVSLTLLINNAAVMLPYVTKQKPLDLFESNTIGPMMLTQSL-SVSRGAIINIASEF--------GSISENTSGSGEYKAMAYRMTKCAVNQFTKTLSIDLKDDHILTAG------------ICPGMVQTDMSKGKGQ-----------LTIEESSSQILAAFNKTHNGGYFRRDLS................................................................................................................................................................................................................................................................................................................................................................................................................................ 247
23 -14.300[IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases  ali follow..  11  2..DLAGKNVVYLGGFGGIGQKCVQELLQRPIKA-LAIFDLNANEQLLAKWKSQHPDTDVFYHKLDITQKSDIDAAYKATHFDVVVNGSGLMNDRL-----ELTIQINLLGVINSTLTAAKGGKGGLIVNISS--VAG-------------QPTAIMAIYSAAKTGVTTFTRAMANPYFYAHSGVGF-LTICPGFTDTGLLEDIGNKTTFTYDTPML-AMFNRVKRQKAEDCARNLVSAIETSKNGTVLMLEMGETTEGLAIFDLIVDD--------------------------------------------------------------------------------------------------------------------------------DLLAEWKKQHPDTEIFYQKMDITQKSDIDAAYKATHFDVVVNGSGLLDDRRIELTIQ-------INLVGVINSTLTALEYMDKSKGGRGGLIVNISSVAGLQPTPLM----------AIYSTSKTGVTTFTRAMASPIHYAHSGVGFITI--PGYTNTGILKDIDKKTTFPFYE-AEVCARNIVNAIETAKNGAVLMLELGEIHELDIPNLWNPQLDDCV..................................................... 477
24 -13.400[I] KOG1478 3-keto sterol reductase  ali follow..  14  2.....RKVVLITGASSGIGLALCKRLLAEDDELHLCLANMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKEQRLDCIYLNAGIMPNPQTADGLQEVFETNVFGIRELEPLLCHSDNPSQLIWTSS-----RSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNV------------ACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVW------FHQKPESLNPLIKYLSATTGFGRNYIMTQK-----MDLDEDTAEKF-YQKLLELEKHIRVTIQ................................................................................................................................................................................................................................................................................................................................................................ 328
25 -12.900[IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  17  1MGKLTGKTALITGASQGIGEGIARVFARH--GANLILLDISDEIEKLAD-ELGGRGHRCTAVKADVRDFASVQAAVARARIDILVNNAGVCRLGNFLDMSEEHIDINIKGVWNVTKAV-----LPEMIKRKDGRIVMMSSVTGDMVADPGE-----TAYALSKAAIVGLTKSLAVEYAQSGIRV---NAICPGYVRTPMAESIARQSNPDDPLTEMAKAIPLRRLADPLEVGELAAFLASDESTGTQNVIDGGSTLPE........................................................................................................................................................................................................................................................................................................................................................................................................................... 257
26 -12.800[Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases  ali follow..  14  1MES-ESPVVLITGSQGGIGHALAREFTEK--GCRVVAT-----SRSRSTMTDLEQDSRLFVKELDVQSDQNVSKVLSE-KIDVLVNNAGVQ-AETPISAMENTFNTNVFGNKDLIFSFNTQAVVPHMVSKKKGKIVNVGSITVMAPGP-------AGVYTATKAAIHALTDTLRRPFGIDVINVVPTNIANSAVATFNKMPELKLYKPYEEAIRERAFISQRMNPTPAETFARDTVAAVLKKNPPAWFSSGRYSTL............................................................................................................................................................................................................................................................................................................................................................................................................................. 276
27 -12.500[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali follow..  14  2..KMTNNTVLITGGSAGIGLELAKRLLEL--GNEVIICGR-----SEARLAEAKQQPNIHTKQCDVADRSQREALYEW-NLNVLVNNAG-KKGTEELFVDGDEIELNFQAPVHLSALF-MKQPEAAIVQVTSGLAF--------------NPLAVYPVYCATKAALHSFSLTLRHHVSVEVIEMAPPMVDTGGISSEEYVQYFLDGLKEGKQEITNERVEGLRDAT........................................................................................................................................................................................................................................................................................................................................................................................................................................................... 236
28 -12.500[I] COG4982 3-oxoacyl-[acyl-carrier protein] reductase  ali follow..  11  354.GLYSSEIAVVTGASGSIAASVAARLLDG--GATVIATTSKLDEERITFYRALYRDAALWVVAANMASYSDIDALVEW-TPTLLFPFAAPRVLSEAGARSEIEMKVLLWAVQRLIVGLSKIGTERDVVVLPGSPNRGMFGGDGA--------------YGEAKSALDAVVSRWHAESSWAARVSLAHALIG----------------------------------------TRGTGLMGHNDVIVSAVEEAGVTTYSTDEMAAMLLDLCNAE---------------SKVAAAGTPIT-------VDLTGGLGEV-----------DLDMAELAAKAREDHAAQAAEDEATEASEVAGTIAALPSPPRGYTPASPHWDDLDVDPADLVVIVGGAEIGP---------GSSRTRFEMEVAGELSAAGVLELVWTTGLIRWEDDPQPGWYDTESGELVD--ESELVERYH--TVVQRCGIREFVDDGTIDPDHAYP--------LLVSVFLDKDFAFVVSSEADARAFVEFDPEHTVI..................................................................................................................................... 814
29 -12.300[R] COG4221 Short-chain alcohol dehydrogenase of unknown specificity  ali follow..  14  3.ESLQGKIAVITGAASGIGLATTEALLEQGATVVMVDWNEKALNDLAAKLG-----ERAIPQVTNLLDADSCNAMIPEIHIDILYCNAGTYIGGDLTETTPEMLNLNVNAVMKNVQAV-----VPHMSERKTGDIIVTCSIAGHFPTYW------EPVYSGSKWAITSFVQGMRRQMIPHGVRV---AQVSPGPVVSALLADWPEENLR--------KAKESGSLIDASEVADAVVYMLTRKRIRDMLVLPTN................................................................................................................................................................................................................................................................................................................................................................................................................................ 239
30 -12.000[R] KOG0725 Reductases with broad range of substrate specificities  ali follow..  14  2......SCALVIGATSTLGKAVVRRLAFT--GYKVAAAADCPNSVGKVAEDNIKVGGDVTAFSLDVANAEHRKELITKVGLDTLIIVPPQNEIETSGEDFDKLFANNLTTPFRLSQAA-----MSTLAKSQNGSIIYLTSCFGFTPSID------MGLYSVASSSVLSLTKSVAQSAAKQGVRV---NSVVSGMIEGDGTGAVWDHASGEEARQIKQSMIPLGRLGRPSDVASYVEFLASTKATGENCIVGGG................................................................................................................................................................................................................................................................................................................................................................................................................................ 248
31 -11.800[I] COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)  ali follow..  13  1MGFLSGKRILVTGVAS-IAYGIAQAMHREGAE---LAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAE-KFDGFVHSIGFAPGDQLDGDYVNAHDISSYSFVAMAKACNPGSALLTLSYLGAERAIPNY-----------------NVMGLAKASLEANVRYMANAMGPEGVRV---NAISAGPIRTLAASGIKD---FRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSSGEVVHVDGGFSIA............................................................................................................................................................................................................................................................................................................................................................................................................................ 254
32 -11.700[G] KOG1203 Predicted dehydrogenase  ali follow..  10  121....TSGIILVAGATGGVGRRIVDILRKRGLPVKALVRNE----EKARKM-----GPEIDLIVADITKENTLVPEKFK-GVRKVINAVSVIVGPKEGDTPE---RQKYNQIKGDSPELVEYIGMKNLINAVRDGVGLENGKLIFGVGDNTFKDLPWGALDDVVMG------------GVSESNFIVDLTAGENGGPTGIF--------------------------------KGIVSTTNNGGFTSVRTKNFPEAENVSAYDGLELRLKGDGLRYKLIVRTSQDWDTVGYTASFDTSPGQWQSVRLPFSS----------------------------------------------------------------------------------PVFRARTVTDA----------PPFNASSIISLQLMFSKFEYDGKLNPTFKEGPFELP-----------------LSSIRAYIQDPVTPRFVHVGSAGVTRPERPGLDLSKQPPAVRLNKELDFILTYKLKGEDLIRD-----GIPFAIVR------PCALTEEPAGADLIFEQGDNIVSRDEVARICIAALESPLNKTFEVFKESSIFRFVAIQKVKFLNWAVLCVVCLFQVKSTVPFSEPFTVDPENPPPEKDYNEYFKTLKDGI........... 608
33 -11.700[R] COG2910 Putative NADH-flavin reductase  ali follow..  17  3.......KIALIGASGNAGSRILKELSDR--GHQVTAI--------ARNPEKIAALPNVVAKKGDVFDQAALSELLKGH--DAVISSVHFTA-----------------DPATLIEAVRASG-VQRYLVVGGAGSLEIAPGQRVVDLPDFPAAYKAEATKGAEFLDKLKQEK-----QLDWTFLSPSAEFVPGERTGKF-------RIGKDNLLSNEQGSRISF----EDYAIALADEIEKPQ.......................................................................................................................................................................................................................................................................................................................................................................................................................................... 193
34 -11.600[I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase  ali follow..  18  71VQKVESPVVVITGASRGIGKAIALALGKA--GCKVLVNYARSAKEAEEVAKQIEEYGQAITFGGDVSKATDVDAMMKTATIDVVVNNAGITRIRMKQSQWDEVIALNLTGVFLCTQ---------RIINISS--VVGLIGNIG------------QANYAAAKGGVISFSKTAAREGASRNINV---NVVCP-----GFIASDMTAELGEDMEKKILGTIPLGRYGKAEEVAGLVEFLALSPATGQAFTIDGG................................................................................................................................................................................................................................................................................................................................................................................................................................ 305
35 -11.500[Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11  ali follow..  12  47PKSIAGEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDIYKVRAKAY-KANVTNYDDLVELNSK-PVTVLVNNAGVMMHRNMFNPDPAMINVNLTSHFWTKLVF-----LPKMKELRKGFIVTISSLAGVFPLPY------SATYTTTKSG----ALAHMRTLRMELDLENQKDI-----HVTTVLPSFLRTNSDVTQLTHTIGFGDVYPLFTGEEVAQRIVAGMVRGE.......................................................................................................................................................................................................................................................................................................................................................................................................................................... 277
36 -11.000[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  10  47SNATPPLRIAIIG-FGNYGQFLAETLISQ--GHILFAHSRSDHSSAARRLGVSYFTDLHDLC---ERHPDVVLLCTSILSIENILKTLPFQRL------RRNTLFVDVLSVKEFAKTLLLQYLPEDFDILCTHPMFGPQSVSSNHGWRGLRFVYDKVRIGEERLRVSRCFLEIFVREGCEMVEM------SVTDHDKFA--------------------AESQFITHTLGRLLGMLKLISTPINTKGYE----------ALLDLAENICGDSFDLYYGLFVYNNNSLEVLERIDLAFEALRKELFSRLHGVVRKQSFEGEAKKVHVFP--------------------NCGENDASLDMMRSEDVVVKYEYNSQVSGSVNDGSRLKIGIVG-FGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKDDLFEEHPEVIILCTSILSTEKVLESLPFQRLKRSTLFVDVLSVKEFPRNLFLQTLILCTHPMFGPESGKNGWNNLAFVFDKVRIGMDD---RRKSRCNSFLDIFARE--VEMSCAEHDWHAAGSQFITHTVGRLLEKLSLESTPIDTKGYETLLKLVENTAGDSFDLYYGLFLYNPNAMEQLERFHVAFESLKTQLFGR--------------LHSQHSHELAKSSSPKTTK........... 636
37 -10.900[R] COG0300 Short-chain dehydrogenases of various substrate specificities  ali follow..  12  1...MRKKTIFITGASSGLGRQLAIDFSWE--ETVLCLFAR-----SQERLENVQRIGEAHIYPVDLADPQSIDRSFAEAVVDVLINNAGYGVFEPFCDSQMDMFRVNVFGLMRATAAV-----LPTMREQGSGHIINIASQAGKIATAK------SAIYSATKHAVLGFTNSLRMELGIHVSAVYTSKVQRIMLDPEDVSEKIVQLTKKPKRELNLPWWMNIGATAY.......................................................................................................................................................................................................................................................................................................................................................................................................................................................... 241
38 -10.800[Q] KOG1205 Predicted dehydrogenase  ali follow..  14  42SEKVNGKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKL-GSPDVAVVRGDVSVIKDCKRFVQETRLDHLVNNAGIAEAKFFEDYSLPIVNTNFWGPVYATHFAIPHLKKTKGKIIAVASPAGWSGVPR------------MSIYAASKAAMINFYETLRIELHPEVGVTIVF--------PGLIENGNTNPDLLAESLLQKQDWSQVVTIESAAECAKAVVNGICRGK.......................................................................................................................................................................................................................................................................................................................................................................................................................................... 273
39 -10.700[Q] KOG1210 Predicted 3-ketosphinganine reductase  ali follow..  14  29..ALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVA-DKLLQAKKEIEMHSINDKQVVLCISVDVSDYNQVENVIKQAPVDMLVNCAGMAVSGKFEDLEVSLMSINYLGSVYPSRAV-----ITTMKERRVGRIVFVSSQAGQLGL---------TAYSASKFAIRGLAEALQMEYNVYITVAYPPDTDTP-CKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSAL........................................................................................................................................................................................................................................................................................................................................................................................................................................................... 277
40 -10.600[Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  14  42.VSAKGLVAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKRMLRQGCDATRLHFIECDLTDFESVRRAAKEDTIDILINNAGIMFQSKTKDGHEKTWQSNHLGTELFLPAVKKSSY-ARIINVSS-RIHLKSEKINLATVDDKKSFGMMKSYRQSKLANVMHARALTKELRKDGAEHVTVNSLHPGVVNTELARNTITAVFRWFLMKTSRDGAQTSIFLALGKKIGGI--------SGKYFADCKLTQENPLALDDQACQDL................................................................................................................................................................................................................................................................................................................................................................................................................ 321
41 -10.500[T] KOG4039 Serine/threonine kinase TIP30/CC3  ali follow..  17  240....KMSSAFVVGATGAVGSELVKLLAESTKFSKVVVLAR--------RPVDGATGDKLIQKTVDFDKLEENAEDIQ--GVDVAFCALGTT---RGKSGADGFYKVDHDYVMSAAKMAKENG-VKQFVLVSS---VGADASSR-------------FLYPKTKGEVEKEIGELN-----KFVIMRPGLIEAKRPEFR------IGEFLGKIVTAPLGLFSNRFS-SSATAIAQAMINATQTEETG-------NQIWNNSKIVEESKKYTA............................................................................................................................................................................................................................................................................................................................................................................................................... 458
42 -10.300[QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases  ali follow..  12  24VSHLQDKYVFITGCDSGFGNLLARQLDAR--GLRVLA--ACLTEKGAEQLRG-QTSDRLETVTLDVTKMESIAAATQDRGLWGLVNNAGILTP--NTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAF--------------VGGYCVSKYGVEAFLRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYLNLVTDCMEHALTSVHPRTRYSAGWDAKF............................................................................................................................................................................................................................................................................................................................................................................................................................. 289
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;