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Query: [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKSLESSAGTVAASPVRRGGQRGLPVPGPPVLSPDLHQLPVLAPLHPAADTRRMCMRTCTLRTRGRRKLast
1 -179.000[T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes  ali  100  1MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKSLESSAGTVAASPVRRGGQRGLPVPGPPVLSPDLHQLPVLAPLHPAADTRRMCMRTCTLRTRGRRK 624
2 -101.000[T] KOG0789 Protein tyrosine phosphatase  ali follow..  13  140......CHVEPYELS-FVDWPTSTTPPVSSTPAEQFNSLTDILDPIEVWLVVLFLESAFVGAFGAYCYWKVQQWRDEKMARE----KAWERRLARVSEVSASKNRNAGGVDPAKRPRESAKWLKHVKEVTL----------------------KRGGVELLPMEDVIVKNKEKFKKPQNELRENEVWVERQTGPDIDKDSDPKTENA--------LDEQDYQLEDGWHGKSALNITRDPSKTVIANWFEWCQPEF--EIPIELTAMSAGNPKLCRDPKVQAWDSTSYLVD-------DTHFIHASTVT---APGKEYIGKAIICQAPFPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDEGATENYGFAEVQLLEKHEMGHLLTRKIELTSGTDDPPIRTITHFQFLKWKEGEGLEGEMSMDAFNYVNHRTRN---NLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKC---GTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKKLKMHHLKFEMEEQWNFLKNYSNKETDK-----------AARDTLAITDQQMCGQTVSFKGVPGQKVRILMRSAEQEMLEEEATDKSVKQRKVGNAKKTGGH.... 745
3 -76.500[T] COG5599 Protein tyrosine phosphatase  ali follow..  24  346............................................................................................................................................................................................TSTMTSKLKPSVGLSNTRDAPKPGGLRRANKPCFNKETKGSIFSKENKGPFNTASIFYKFKRLEEMEMSDWCCLASSRSTSISRKNRYTDIVPYDKTRVRLAVPKG---CSDYINASHIDVG-------NKKYIACQAPKPGTLLDFWEMVWHNSGTVIVMLTNLYEAGSEKCSQYWPDNKDHCLEGGLRISVQKYETFEDLKVNTHLFRLDKPNGPPKYIHHFWVHTWFDKTHPD-IESITGIIRCIDKV----PNDGPMFVHCSAGVGRTGTFIAVDQILQVPKNNLEDSKDFIFNCVNSLRSQRMKMVQNFEQFKFLYDVVDYLNS-GVNQASKPLMT............................................................................................... 711
4 -15.600[V] KOG1720 Protein tyrosine phosphatase CDC14  ali follow..  19  178..........................................................................................................................................................................................................................................................................................................FNVLTPDFIAFASPQEDHPKGYLATKSSHLNQPFKSVLNFFANNNVQLVVRLNSHLYNKKH---------------------------------------------EDIGIQHLDLI-FEDGTCPDL-SIVKNFVGAAETIIK---RGGKIAVHCKAGLGRTGCLIGAHLIYTY--------GFTANECIGFLRFIRPGMVVGPQQHWLYL................................................................................................................... 331
5 -15.400[T] COG2453 Predicted protein-tyrosine phosphatase  ali follow..  13  2.............................................................................................................................................................................................................................................................................DYQDDGLGEMIEFLEDKLYYTSLSQPPKAELYPHMHF---FTIDDELIYNPFYHDFGPLNSHLIRFAVIV-AKKSKAIVLYSSTDTRLRANAAPFLGFRDAGYAVSDYYITIQDENGDFNWISPKFIAFASPIQAENVGIRHKEMY-FEDGTVPEL-SLVKEFIDLTEEVEED----GVIAVHCKAGLGRTGCLIGAYLIYKH--------CFTANEVIAYMRIMRPGMVVGPQQ-HWLHINQVHFRAYFYEKAMGRAIQQATAAEPLATPPRHPLNATNGTSQSNISTPLPEPTPGQPRKVSGHNPPSARRLPSASSVKFNEKLKNASKQSIQNENKASYSSYEDSEIQNDDE. 447
6 -12.600[T] KOG3697 Adaptor protein SHC and related proteins  ali follow..  22  499...WYQGEMSRKEAEGLLE---KDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTK-DRVFDSISHLINHHLESSLPIVS-AGSELCLQQPVERKQ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 594
7 -12.300[A] KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit  ali follow..  14  8.......................................................................................................................................................................................................................................NASPQPEEDDEPYVRHLEDYSSRDERIESAVEIARREREERKKRMRYDKPTHNSQ-YYQNRNTKAYDRYKIPQGWLD--CPPSGNEIGFLVPSKVPLNESYNN--HVPPGSRYSFKQVIHNQRIAGRK----------------GLVIDLTNTTRY--YSTTDL---------KKEGIKHVKIAC-KGRDAVPDNVSVNAFVNEVNQFVLNLKHSKKYIVHCTHGHNRTG-FMIVHYLMRSG-------PMNVTQALKIFSDARPPGIYKPDYIDALYS.................................................................................................................. 253
8 -12.100[R] COG5350 Predicted protein tyrosine phosphatase  ali follow..  11  2.............................................................................................................................................................................................................................................................................................................................TCIVVSPLSRIAEMAV-------KHKAREMVTLIAKEQSFHR------PAVVAAERHLTLAMNDIAFKGTGDLIAPD-----------------------------------DAHVLKLIDFAGEWDQSAPLLIHCWMGISRSPAAAVIAALSLY-------PDQDETELAQRLRTVSPRIIAIGDRLLGREGRLVKAIKAIGRGADTDG................................................................................................. 162
9 -11.900[T] KOG4566 Cytokine-inducible SH2 protein  ali follow..  20  384...WYWGPITRWEAEGKLAN-VPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDHTSIVDLIEHSIRDSENLPGSATYPVRLTNPVSSLQYLCRFVIRQYTRIDLIQKL..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 520
10 -10.800[TR] KOG2283 Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases  ali follow..  12  30........................................................................................................................................................................................................................................................................AGRLFSNLKDNLKDTLKDTSSRVIQSVTSYTKGDLDFT------------------YVTSR---------------------IIVMS-------------FPLDNVDIGFRN-IRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSEC---SWPIRQAPS--HNLFAVCRNMYNWLLQNPKN--CVVHCLDGRAASSILVG-AMFIFCNLYSTPGPAIRLLY----AKRPGIGLSPSHRRYLTIKSITVSPIPFFNKQCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVVVSMYHLRSTIGSRLQAKVTNTQIFQ-----QFHTGFIPL--DTTVLKFTKPELDACDVP 350
11 -10.500[V] KOG1716 Dual specificity phosphatase  ali follow..  12  59................................................................................................................................................................................................................................................................................................................................YLGSYDNASRS-----ELLKTQGISRVLNTVP-------MCQNLYRN-------------------------------------------SFTYHGLDNEKVLQFDDAI-KFLDQCEK------DKARVLVHCMSGKSRSPA-VVVAYLMKR-------KGWRLAESHQWVKQRRP-STDISPGKYLDFG-----LETYLLFLKLLLIAFSLYTEFYQQLQEFEQGIFGSEMMSAMNINDAPTFGFGFPKIDNQAQAPVFNNAPTSSIFSSPASSIPPQEFTFGATPPKPTTGGDIAMDGS... 283
12 -10.500[V] KOG1572 Predicted protein tyrosine phosphatase  ali follow..  9  72.............................................................................................................................................................................................................................................................................................................................................................................PDSANFSFLQTLGLRSI------------IYLCPEPYPESNLQLFQFGIEGNKEPFVNIPDHKIRMALKVLLD-----EKNHPVLIHCKRGKHRTGCLVGCLRKLQKWCLTSIFDEYQRFAA--------AKARVSDQRFMEIFDV................................................................................................................. 200
13 -9.180[T] KOG0197 Tyrosine kinases  ali follow..  16  124...WFFRSQGRKEAERQLAPINKAGSFLIRESETNKGAFSLSVKQGELIKHYKIRCLDEGYYISPRITFPSLQALVQHYSKKGDGLCQR--LTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKL------SGQFGEVWMGYYKNNMKVAIKT-------------------LKEGTMSPEAFLGEANMMKALQHERLVRLYA------------VVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD--RAANILVSEALCCKI---------ADFGLARIID----------SEYTAQEGPIKTIKADVWSF---------VLLMEVVTYGRVP----YPGMSNPEVIRNLEYRMPRPDTCPPELYRGVIAECWRSRPEER----------PTF------EFLQSVLEDFYTATERQYELQP................................................................................................................................................................................ 505
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 4 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;