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Query: [R] KOG0835 Cyclin L, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRRLast
1 -97.400[R] KOG0835 Cyclin L  ali  100  1MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR 526
2 -77.000[DKL] COG5333 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit  ali follow..  29  2............................................................ADSLVHSSSQLEAFDSEYAEELCTLGSEWIQEAGVLLNLTQNCVIVCLILFRRYCTLYPPRVPDLDAIVMACVSIGSKTTETPASVQDICNVVVYLKERFKDGFIAHDLYSEEMYSSRNRLSNMELEVLRALNFDTHIVIPHKLAIHYLQTLQLIDNKKLLQITWNFLNDASRTRLCVLYPPFSLACGCIAMAARVIGMKLPK--DWYRVFDTTKEEIDSLTSILENFYKTSAIAHKTLYLIFTEQVSA......................................................................................................................................................................................................................... 258
3 -73.000[D] KOG0834 CDK9 kinase-activating protein cyclin T  ali follow..  16  2...................................SNSNKLIAEKNGSRYGRMIHPWLRKKQDLADTPSRREGMTYEEELSKRQQGGVFIFDIAMQLTHEHGLSGVAATLFNRFFNVHSLKRCDFRDVAAACVFLAGKNEDAPKKLKYVVTQLWQFKYPHN----KQFQSEQHFLDQCNVVTLIEDVLLKTISFDINVDLPHQYVLKLMRDVEKGRNDMVKTAYYMATDVLIITDWSVRYSCASIATACVNIAAFFHNINMDDSDRWYRLEDMTREEVEAMTKEFLDIFSRNPQFHIGSLKKIDPLGKVKIVGMPPQVSSTVTPSGSSSNLKKIDLESYKGRPKPLSNSSDSPSTRPSFLPDVKNQKVVEQELMEQRMKEAAQQKIHRNGHRPSSSSHPLHHHSTSSSASNNSNHQNRSSSGLSAHQHQKPYNEDSRSAKRSMMYEETNSSKKPRIDYKMSFVASSSTTIATMHNDHFSQTTHQQNISTYARGVNEMMLNQVAPPPLMSVSAQPSTYQKMCMEYQR 503
4 -68.500[K] KOG0794 CDK8 kinase-activating protein cyclin C  ali follow..  22  2........................VAPRPLRRVVLFYQGKLCSMAGNFWQSSHYLQWILDKQDLLKERQDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTR----FSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDM--LLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQ---WFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS................................................................................................................................................................................................ 303
5 -51.500[DKL] KOG2496 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit  ali follow..  14  4.................................................NSSQKRHWTFSSEEGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRES--------------PLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVES.............................................................................................................................................................................. 322
6 -23.500[D] KOG0656 G1/S-specific cyclin D  ali follow..  17  49.........................................................EMVEKEKQHLPS-DDYIKRLRSGDGRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLKGWILQLLAVACLSLAAKIEETPMLIDLQVGDP-----------------QFVFE--AKSVQRMELLVLNKLKWRLRAITPCSYIRYFLRKMSKCDQNTLISRSLQVIASTTKGIDFLEFRPSEVAAAVALSVSGELQRVHFDNSSFSPLFSLQKERVKKIGEMIESDGSDLCSQTPNGVLEVSACCFSFKTHDSSSS................................................................................................................................................................................................................ 303
7 -23.000[D] KOG0653 Cyclin B and related kinase-activating proteins  ali follow..  10  60.........................................................YLVHHEKKYVLDDSFINGGNVNSKMRRILVDWLVQVHLRFHLTPETLHLTIFVLDRIIVKNIVSKAEFQLLGVAALFVASKFEDYLPDILEYELIT-----------------ENTFS--KKQILAMEQTILNALNFDLSCPSSLVFLRYISKTLTENDVNYVHNISKCLGELALLDSVMSTVPRSHVASASMIITLNIISVDGINPKTAASMIGASKQDIYDAISLLAQVAYKNFRHQK..................................................................................................................................................................................................................................... 293
8 -22.300[D] KOG0654 G2/Mitotic-specific cyclin A  ali follow..  16  179.........................................................NIHVAELQQRPLAMELVQRDIDPDMRKILIDWLVEVSDDYKLVPDTLYLTVNLIDRFLSNSYIERQRLQLLGVSCMLIASKYEESAPGVEEFCFIT-----------------ANTYT--RPEVLSMEIQILNFVHFRLSVPTTKTFLSALFLIIILQVFIELEYLANYLAELTLVEYSFLRFLPSLIAASAVFLARWTLD---QTDHPWNPTLRYEVAELKNTVLAMEDLQLNTS......................................................................................................................................................................................................................................... 400
9 -21.600[D] COG5024 Cyclin  ali follow..  20  143.........................................................YIRKLDLKCLPN-PKYMDQQKELTMREILNEWLVEIHSNFCLMPETLYLAVNIIDRFLSRRSCSLSKFQLTGITALLIASKYEEMCPSIQNFVYMT-----------------DGAFT--VEDVCVAERYMLNVLNFDLSYPSPLNFLRKISQA--EGYDAQTRTLGKYLTEIYLFDHDLLRYPMSKIAAAAMYLSRRLLR-----RGPWTPKLGYEEHELKEIAYIMLHYHNKPLE........................................................................................................................................................................................................................................ 360
10 -19.000[D] KOG0655 G1/S-specific cyclin E  ali follow..  11  104.........................................................IMLNKEKTYLRDQH--LEQHPLLQMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMTQENVVKTLLQLIGISSLFIAAKLEE-PPKLHQFAYVT-----------------DGACS--GDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDPQQIFIQIAELLDLCVLDVDCLEFPYGILAASALYHF------------SSSELMGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPE.................................................................................................................................................................... 393
11 -17.100[K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB  ali follow..  17  111....................................................................QKRIKVSNAAERNLS-QALQELERMAFNLSIPNDVRETAAVIYRKAVKQNMIRGRSIEGVVAGALYAACRITNVPRTLGEIASVTR-----------------------KKEIGRTYRIMSRYLKLNIMPSKAEDYISRFCSKLKL--SMDTRNKALEILRDAENVGLTSGKGPTGVAAAAIYIASLITGERRTQRA---EVAGVTEVTIRNRYKELTE............................................................................................................................................................................................................................................... 304
12 -16.200[K] KOG1598 Transcription initiation factor TFIIIB, Brf1 subunit  ali follow..  12  81............................................................................SRAQTLQ-NGRRHIHHLGNQLQLNQHCLDTAFNFFKMAVSRHLTRGRKMAHVIAACLYLVCRTEGTPHMLLDLSDLLQ-----------------------VYVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLEFEKNHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKE---SVVKVCESTLRKRLTEFEDT-ECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISSYQDAIEIELENSRPKAKGGLASLAKDGSTEDTASSLCGEEDTEDEELEAAASHLNKDLYRELLGGAPGSSEAAGSPEWGGRPPALGSLLDPLPTAASLGISDSIRECISSQSSDPKDASGDGELDLSGIDDLE-NESEARVKAERENAEYLREQREKEARIAKEKELGIYKEHKPKKSCKRREPIQASTAREAIEKMLEQK 532
13 -15.100[K] KOG1597 Transcription initiation factor TFIIB  ali follow..  16  83...........................................................SGDFLSSSLGRWQNRGSNPDRGLI-VAFKTIATMADRLGLVATIKDRANEIYKRVEDQKSSRGRNQDALLAACLYIACRQEDKPRTVKEICSVANGATKKEIGRAK--------------EYIVKQLGLETGQLVEMGTIHAGDFMRRFCSNLGM--TNQTVKAAQESVQKS--EEFDIRRSPISIAAAVIYIITQLSDEKKPLRD---VATGVAEGTIRNSYKDLYP............................................................................................................................................................................................................................................... 290
14 -14.000[D] KOG4164 Cyclin ik3-1/CABLES  ali follow..  16  368.........................................................CESAERAKQVINED--LTLSKMKSLKRE----MAELGVSNGIDVYTVATAYVYFEKIILKKLISKVNRKCVAGAALLVALKMNDKKSTIKSYIEQA-----------------EDQLREPKSDLLAYELPICSVLQFRLQP--TIDEIQPHVDRL.......................................................................................................................................................................................................................................................................................................................... 540
15 -9.300[S] COG5373 Predicted membrane protein  ali follow..  11  38IARLAKEGMGEPGPDLATGRPSEAGVPSVAGTEATADGPWSRAREGAGTSHDESAAGRESGDGAIDGPVAPSAAAARAESLESRIGGRWPVWVGG------LALALGGYFLVQYSIEAGLLSPAVRLTLAAIFGLA------------LGVAGEVIRRRDVPAIAD----RFRNAMIPGVLTAAGAVTLTGAAFVLLA-----LVSLATVGLSLLHGQALAGLG---LLASLLTPLFVSSGEPRPWVLFGFLAVWLATLAASRLRRW................................................................................................................................................................................................................................................................... 290
16 -9.080[S] KOG4610 Uncharacterized conserved protein  ali follow..  10  153..................................................................................................IEQFLM---ILIVGRWLLKGDLTRDQLSQLLLVYIGTAADIIE--------------------------------FDSYKDDSIAKIGFLVFLT---------------------------LGIWSWSLMQFTIVLSATRGRRPRGSGSHHKEEHTDCCQNCCCGIDVWGIVLNVILQDAPFLTFRLLIIFQYKIINYMNVFFTCKNSLVIILQLYRLYVVNAEFWKNRRESRMAKSRQFQSRRKVQDADQNSIYMISNERGGDVKKKIKRAKDKDYAEQEAVYSKKKKDKKDKKKRKRKDTGYSTASSQNLYSTKASGTDKDTRRKDKKGKKSKRTCSSSPSDCDLAKKQKRKNADKNDKKKSRKIEAVVEESSSSSSSSSDSSNSTLPSYEVIDEKKARRRKHRGSSSDTSSGDSSSSSSSSSSSD 521
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 3 7   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.