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Query: [U] KOG0946 ER-Golgi vesicle-tethering protein p115, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSEIIGYALDILYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHILast
1 -164.000[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali  100  1MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQAMEHLIHVLQTDRSDSEIIGYALDILYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQQENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSREVIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGATSSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNPPRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI 962
2 -35.900[U] COG5064 Karyopherin (importin) alpha  ali follow..  12  144...LTNIASGTTDQTRIVVDSGAVPRFIQLLSSPEKDVREQVVWALGNIAGDSSAVLGNGVLQPLLNILQSSASDVSMLRNATWTLSNLCRGKNPPP------------------NWSTISVAVPILAKLLYSEDVEIIVDACWAISYLSDGPNEKIGAIL--DVGCAPRLVELLSSPSVNIQTPALRSVGNIVTGTDAQTQIIIDCGALNAFPSLLSHQ----KENIRKEACWTISNITAGNTQQIQAIIESNLIPPLVHLLSYADYKTK------------KEACWAISNATSGGLGQPDQIRYLVSQGVIKPLCDMLNGSD--NKIIQVALDAIENILKVGEMDRTMDLENINQYAVYVEAGGMDMIHDLQSSGNNDIYLKAYSIIEKYFSDEDAVEDLAPET............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 513
3 -34.700[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  12  31...LLSFLE-DRNEVNFYSEEPLRALTILAYSDN-LDLQRSAALAFAEITEKDVREVDRETIEPVLFLLQSPDAEIQVKLNGLDLLIRQMMSPHVEVQCNAVGCITNLATLDENKSKIAHSGALGPLTRLAKSKDIRVQRNATGALLNMTHSYENRQQ---LVSAGTIPVLVSLLPSSDTDVQYYCTTSISNIAVDAVHRKRLQSEPKLVRSLIQLMDTS----SPKVQCQAALALRNLAS-DERYQIEIVQSNALPSLLRLLRSSYLPLILA---------SVACIRNI-------SIHPLNESPIIDAGFLRPLVDLLSCTE-NEEIQCHAVSTLRNLAASSERNKRAIIEANAIQK----------LRCLILDAPVSVQSEMTACLAVLALSDEFKSYLLNFGICNV--------------LIPLTDSMSIEVQGNSAAALGNLSSNVDDYSRFIECWDSPAG------GIHGYLVRFL-SSEDSTFAHIAAWTIVQLLEAGVPRLTAFIQSSDDIIELLNDIVARDANNGEYEDGEGDVI.................................................................................................................................................................................................................................................................................................................................................................................................................................. 534
4 -34.200[U] KOG0166 Karyopherin (importin) alpha  ali follow..  12  151...LTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMVLDCNILPPLLQLFSKQ-NRLTMTRNAVWALSNLCRGKSPPP------------------EFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVI--DAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSP----KESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEA--------------AWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDS--KIVQVALNGLENILRLGEQEAKRNGTINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 517
5 -32.500[S] COG5369 Uncharacterized conserved protein  ali follow..  10  30IVPFKNVIGRPDRKEYAIRNGAPKLLLNLFSLENLSMNKYQVFVVLNSLMSEDQDFLRHEDLLSVMQMISKDSTPYGMLNITLKVFNTMLSFDGHVSPRDMDLDEIENVFEGNKDKVALGDEYITQLFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQMIVTPILIRLFFESRE-AKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEDELQSSAACECLLSLSRSVYILRTGLADADVSEPLIKLLSDPDTRVK---------------STATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDS--SLRKKTVWVLRHVVFGDDET----IQLEPLKKIGASKLVELC-----NDEDLGVQEQMLQVLRNFTCQKEESVDFLLKM----------PMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELRDSILR--------------LLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDLQEDDFDREMRPPFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSPSQEDKERASILQN-LG---FGECLQMLQNHS...................................................................................................................................................................................................................................................................................................................................................................................... 710
6 -32.500[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  10  30IVPFKNVIGRPDRKEYAIRNGAPKLLLNLFSLENLSMNKYQVFVVLNSLMSEDQDFLRHEDLLSVMQMISKDSTPYGMLNITLKVFNTMLSFDGHVSPRDMDLDEIENVFEGNKDKVALGDEYITQLFCLVRQFDPCIRLLSISCLVTLYKAGILSKNQTKEIQMIVTPILIRLFFESRE-AKQIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYATKEEDELQSSAACECLLSLSRSVYILRTGLADADVSEPLIKLLSDPDTRVK---------------STATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDS--SLRKKTVWVLRHVVFGDDET----IQLEPLKKIGASKLVELC-----NDEDLGVQEQMLQVLRNFTCQKEESVDFLLKM----------PMELLAKILLEKLESKNPILIEPSIYILVHIAASDGELRDSILR--------------LLLLVKEIMLQEAQRLKPEQMSTNVSSPESDSEMDLQEDDFDREMRPPFDIYEEDTYEPNSEILLAGIWLCINILWPKQCTSPSQEDKERASILQN-LG---FGECLQMLQNHS...................................................................................................................................................................................................................................................................................................................................................................................... 710
7 -30.300[S] KOG4646 Uncharacterized conserved protein, contains ARM repeats  ali follow..  12  1.............................................MAQKPKVDPHVGRLGYLQALVTEFQE-TQSQDAKEQVLANLANFAYDPSNYEY-------------------LRQLQVLDLFLDSLSEENETLVEFAIGGLCNLCPDRANKEH---ILHAGGVPLIINCLSSPNEETVLSAITTLMHLSPPGRSFLPELTATPVVQCMLRFSLSA----SARLRNLAQIFLEDFCS-PRQVAEARSRQAHSALGIPLPRSVAPRQR................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 198
8 -28.800[U] KOG4809 Rab6 GTPase-interacting protein involved in endosome-to-TGN transport  ali follow..  13  372........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLT---NQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDEKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP 703
9 -28.500[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  12  2...................ATEIDDLIEKLKTTSVSPANTTNLLCEISATKDPKLFDKHELAECFLGLTKCD--DTNVRKEAAKCIAEITKSEVQRKK-------------------FTKRNIIAAFLECLSDGSMELPIQICRALGNICYLNDE--ARDLILELEGDAVLLRLLDINAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQGIIDIGAASTNPDLAEMCLELLHYQAE-SDEVKLILAKDGLCETIYNLLEKYKTLASTSEAR--------ALMKLACELIVLILTGDDSMHYLYTTPLLKNMVDWLDSTDI--DLLTTGVLALGNFARTDSHCIY------FVEQQTMNKLLEVLAKNNGVKDDVRLQHALLSALRNLVIPKPNKNAVIQAGLVQ--------------TILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALELLK----------NKTLIEQLVHWSKSSDYAGVTGESLRLMAWLIKHARSSLSEFLANEGTVEAMVSML----TAQHLVMQNEALIALCILSVVYLSQPSEAAQKKLAELISKS--VENLQNCVNLLKSSEQLVA.................................................................................................................................................................................................................................................................................................................................................................................. 611
10 -26.700[Z] KOG1003 Actin filament-coating protein tropomyosin  ali follow..  10  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQ---EKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLELNN................... 283
11 -24.100[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  340.........TDSQLGNADMEMTLERAVSMLEADHMPPSISAAATFIQHECSEARKRVQLRGILKLLQLLKVQ--NEDVQRAVCGALRNLVFEDNDNKLE------------------VAELNGVPRLLQVLQTRDLETKKQITDHTVNLRSRNGWPGAVAHACNPSTLGGQGGRITRSGVRDQPDQHGLLWNLSS-NDKLKNLMITEALLTLTENIIPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSY-DVPMPEEKSNPKGVEWLWHSIVIRMYLSLIAKSV-RNYTQEASLGALQNLTAGSGPMPTSVAQTVVQKESGLQHTRKML-----HVGDPSVKKTAISLLRNLSRNLSLQNEDLVSIIPDTVPSTDLLIETTAS----------------ACYTLNNIIQNSYQNARDLLN--------------IQKIMAISAGDAYNKASKAASVLLYS-LWAHTELHHAYKKAQFKKTDFVNSRTAKAYHS............................................................................................................................................................................................................................................................................................................................................................................................................................................. 878
12 -23.700[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  11  22.........NETSVKEFLDRFPLPVIFNALQTDPDIPGFENLVTCLERLFKTKYASLIPQYMPVLQVGLKAD--SAVVKSLACKTVLCLLEDCDTNDVSSVQ--------------LVVNNGIYPLLLDYIINSDDEVANAASETIKSLAR-FPDAMSVIFPSETNDPTHLRNLAARCSSLARVRVLSLIVKLFSISRLVASEVKKSGLLDLLEAEMKG---TKDTLVILNVLELYYELME-VEHSSEFVPQTSLIQLLCSIISGTSTGPYEKLRAM--------MISGRLLSKENIYKVVEEASVKALISAIDGSLESVEMNDT--DAQEAAIDALGQMGSTTKGADLVLSTSP--------PAARHVVASAFDRNAHGKQLAALHALANIAGETRPKSNRIVDG-------------------------------------------KAEESLRCLIYDAAAQSTKLTPSGLFLSV-----LQQSSEIRLAGYRTLTA-LVARPWCLVEILAKEEIINIVTDATTETAKIAMEARYNCCKAIH--------------EAFLCSNFVDDPRRLKTGDKLQEAVRSGPYMSKKHRGARP------EVMTGEGF............................................................................................................................................................................................................................................................................................................................................................. 519
13 -22.400[S] COG4372 Uncharacterized protein conserved in bacteria with the myosin-like domain  ali follow..  12  23............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DHLGSKVGKARLRLFKLRPRQTAVLLTVITGTLISASTLGILFTFSKSLREGVFQLDDILAQLRVAKTELEQAS---QAKEEIESELTAVREEQQLVQERSRELNRNYTKALQLLRR-------------VSEQSRNLRQEVANLSAERAQLNEQKDSLLAESSELQSQVKLRDQELSKRQERIAQQEKVLARQREQVQSLEKRFASLEAQRQQLQAEINQRDTKIDQLDQAIAAKDNDIQAREEKLQGLETELSFLQREVEELERYYQDYQELRGQQIAILRGQLLAFGGLRVVSSEAVTGAVDQL... 313
14 -20.200[D] COG5185 Protein involved in chromosome segregation, interacts with SMC proteins  ali follow..  11  105....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YQQECATQVVNYLLESG-FKHLYNKLDPNFRFGARYEEDVTTCLKALNYPF----LDSISRSRLVAIGSPHLGMLHWVVSLIQCTEKAVAMVYTVEQNSLDDHLVDKVLSPEESEPEKELKATFNQQNQDLYNQTEALKSTNEELINQIKSAEELDSAIQVLEERYRTMQRDEVKFQSAMSGMKSKMESRTNLMKQLQVNIEEKESQLQLLKEKRDSLKYQVENQDISISEFEKMVSEREQLDRNLNMIGSKISELRKEVFDTDLLIQASIDSLEKKVQKGPNYINLDLKNKVRPFINEVRRSITLEFHEEQNKSLKLQEHVDTVNDLIAELQDELRGIESRLTSVLSECNMLRETASE---EKNAFDAESDKLERELQQLKLSS---HNSMLQLDQRIQSINIEADQIAHACMEYKNNI---YKEVAFVLGEIIHFKLHVQDSLEDLKMDYQKELDDLSR. 621
15 -19.400[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  369..........AKLTIAELRERKILRLLLKVKNGT--PMRKSALRQLTDQARDFGA---AALFNQILPLLMERTLEDQERHLLVKVIDRILYKLDDLVRPFT-------------------HKILVVIEPLLIDEDYYARAEGREIISNLAKA---------SGLAHMIATMRPDIDHVDEYVRNTTARAFSVVA-------SALGVPALLPFLKAVCRSK---KSWQARHTGVRIIQQIALLLGCSILPHLKN-LVDCIGHGLEDEQQKVRIMTAL------SLSALAEAATPYGIEA-----------DSVLKPLWSGVQRHR--GKSLAAFLKATGFIIPLMEPEYAS---------HFTRRIMKILLREFNSPDE-EMKKIVLKVVSQCASTDGVTPEYLRTDVLPEFFHCFWSRRMASD-----------RRSYKQVVETTVVLAQQVGSRQIVERVVNNFKDESEPYETVDKVIGSLGVSEIDERLEELLLDGVLFAFQEQSVEEKVILTCPYLPQIVSTILYRLNNKSANVREQAADLVSSITIVLKACGEEALMRKLGVVLYEYLGEEYPEVLGSILGAIKAIVSVVGMSSMQPPIRDLL---PRLTPILRNRHEKVQENTIDLVGKIADRGSEYVSAREWMRICFELIDMLKAHKKSI-------------------------------RRAAVNTFGYISKAIGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCMPFTVVPALMADYRTPEMNVQNGVLKSLAFMFEYIGEQARDYVYAITPLLADALMDRDAVHRQTAASVIKHLSLGCVGLGVEDAMIHLLNILWPNILEESPHVINAVREGIDGIRNCIGVGPIMAYLVQGLFHPSRKVR--NTYWTSYNSAYVQSADAMVPYYPHVDDDQFN........................................... 1177
16 -19.300[S] KOG2734 Uncharacterized conserved protein  ali follow..  10  87...ILKYVENEEADGDVLDEQSLKKLILVFESEVELHTVIQELKGVATVPDLYPILVDLHGLHSLLELLAH--QNTDIAVAVVDLLQEVTDVDILGESQEGAESLIE---------ALRKEQICALLVQNLEKEEADGVHNTLAIVENLTEIDSEFVKE--AAEQGLLAWLLKRLRGKSDPNKLYCSEILSILIQTENENRLLLGSLDGVDVLLQQLADPASNEEQEYMQNLFNCLCSALM-ARENRDRFLSGEGLQLMNLMLREKKMSRN----------GSLKVLDHAMA----GQDGRDNCNKFVEILGLRTIFPLFMRLISADEHEEHVTSVIASMLRNCKGTHR-----------------QRMLAKFTENDHEKVDR-----LLELHLKYLAKVEAIDKEIDQQAKDPTIDEDEEAENNYIKRLTGGLFTLQRIDYILLEVSATGDTVKQRVLQILNLRGAS--------------------------------------KTIRSIMRE------YAGNLGDGDTDWREQEQNHILSLV................................................................................................................................................................................................................................................................................................................................................................................................................................. 578
17 -18.500[D] KOG4438 Centromere-associated protein NUF2  ali follow..  11  39..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVHLMEGFLPFSNLVTHLDSFLPICRVNDFEPKAKRTSRFLSGII---NFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQFHQKTIVLQEGNSQKKSNISEKTKRLNELKLLVVSLKEIQESLKTKVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFK---INKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTAEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST............ 464
18 -18.500[S] COG1340 Uncharacterized archaeal coiled-coil protein  ali follow..  11  1..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTDLLQEFEEKRDILRKAIEEHIKKRDEAAQQSRNYAEQRDQLNAKAHEMRDQVKQKISQKNALIEEVQKIRTEKEEHFQKLSELRKEYKKITEEANYASVNQRDIKAKERELQKLIKKQETMQLPKAEEDKVVQEIKRLSNEIKKMKEDREKQLSENEKVKALLAEIDKEKTLARDLKKRAEEISNQISEISNDINKSLQELDEVRKKADEMHEMAIKYGKESEQEHEAFIQAKNDLKDLEKVIAGLRTKKRATKKKEKDDEQKAEVLFEKFKN-GEELTTDD........................ 285
19 -17.700[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  12  345.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SELQASQEYNLSLSRQCQDIQYIYSSRLYSLINDRIHHWNAE----------LDRYKILTEAIQAERSFVMRRDKELNLRAESLEAANHKTTTVGSRIEVLEKKLQSCIIEKNGLELETEEAIQDKSEFIAMASTLSKEMEMMEAQLKRWKDTAQDALYLREQAQSLRVSLSNKADEQKGLEDKCAKQMAEIKSLKALIEKLLKEKLQLQNLASIRTQLDLSEREVLELKEGIKVKEQEAEASIAEMETIGQAYEDMQTQNQHLLQQVAERDDYNIKLVSESVKTKHAYNTHLSEKQVMEKQLHQVNASVENFKARIAHNEEQMKGCFSEAYKLIQEDRHLVISLETTKWEVADADKEFRWLKSAVSSSEKEYEQISRRTDDIKLELDDEREKKKLEEE.. 811
20 -17.700[L] COG0419 ATPase involved in DNA repair  ali follow..  12  58...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DKEEEKLFVEHCHSMIDVIPSKSAEVYSHLETLTKTFKNLS-EAKPIFDEIELLDKRLSETKTELSDLQGDLQGLDIRKDEIQSELDTLYLRRANLEKLQLDISNLEEEIRTIDRETEVLRIELPSSIAHDEIYAEREKLLEKRGYLRKQIERTKLEETSFKKKIDDAVLANNEQKLKLTKLNFQVNELEKDINKSSEDCDLQKKKLLEVSSKQGSQAPFLNELESEYEKLEADIQEMAQKSRTEILEANEYLHQLNEWNSELRIVSTKFKCIKEKKSNIGEEVRIIASKIESTDDNLRKLQERLADLRTRERNASDNL 385
21 -17.600[U] COG5215 Karyopherin (importin) beta  ali follow..  10  1................MSTAEFAQLLENSILSPDQ-NIRLTSETQLKKLSNDNFLQF----AGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQI-------TNALTALVSIEPRIANAAAQLIAAIADIELPHGA------PELMKIMVDNTGAEQPNVKRASLLALGYMCESADPQSQALV-SSSNNILIAIVQGAQSTETSAVRLAALNALADSLIFIKNNMEREGERNYL--------------------------------------------------------MQVVCEAT--QAEDIEVQAAAFGCLCKIMSLYYTFMKPYME----------QALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQ------------LFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQ------TYYVHQALPSILNLMNDQSLQVKETTAWCIG---RIADSVAESIDPQQHLPGVVQAC--------LIGLQDHPKVATNCSWTIINLVEQLAEATPSPIYNFYPALVDGLIGAANR---IDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLGKG-KALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALNGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKRQL... 859
22 -17.500[C] COG1413 FOG: HEAT repeat  ali follow..  12  14..................KLELFFFSILVVLSYA-LFSGNDSGTGTES--------MNNYFWVPSTVMQSI--AAVYAVFIAIFALSLQRNLDSIHSIANRLKPPLKIVSYTAVGS-IYLNGLMLIIFSLHSPSELKIELMLFTSLLSLVASLIAIVYLSMVSGLKTSSEKFTYLTNLLRELEGWSSSGQMEL-------------PGDMELCVQGLEDE----KPEVRIAAAQLLGWL------------DEQAVDALLRKLADKNPRVREAAVEALGRVGDENIVAELIGCLEDKNKGLRLQAVLGDERAVDPLVKKL--EDKAPEVQAAAAEALGNL-----------------SQDSMDVLLKKLEESPMAGAPTEFQVQVLTALGKI--GDEKALAAILSRLDSPYPDIRKHAAEALGNLRDE-----------AVPHLVKKLADISPEVRNASVYALGNLGDERAVSPLLRML----EEPDPELRITAVYAL--------------LRAPQAISPLINML----DDDNPWVRKCTAEALGPLVKNLDDPDSNVRWAAAEAL--RMLDKRDLRKDSNGN.......................................................................................................................................................................................................................................................................................................................................................................................... 507
23 -17.300[D] KOG0995 Centromere-associated protein HEC1  ali follow..  68....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LVSLNGSKIYNFLVEYESSDAPSEQLIMKPRGKNDFIA-CFELIYQHLYEFPRHER-PLKNSYYQPMGSSHLDALSWLIDISAVSEDTQNILFGDFMEQGKAQEKTLNYAWAAENPSSSYWDDTKHRLRKYFEQSNEFEDMTKTAASALEMLNYECDEIEADKGNEASLKEEISRIRDDIRKAKDYLEQNLHVKQHMEKELAMVKSEQEEKISENEKVQKMVDDLKNKIELQKQIHKEVRQMNLDNNKDKEVVLEIQSELDRLSKETWKLKDEDFFKEQKSKFIHLAEQIMKILSGLNIQMKIWVPEISRQLHQRKLELETEQSRFSNKAVTAEERIQIQSETLCEAKKNEAREERIRRNERD--SWKDARKHIEQRYEQLLNEKEVLLKQMKLDGSLEKEIEDETARMSATGEEHIQKRSQLEAGIRQILDLMVVE---IAEIENKKIGFHVQCAGIEKAV 589
24 -16.600[S] KOG0992 Uncharacterized conserved protein  ali follow..  11  77...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ERDLNEELLKN---QNQHKKELDAQVRRIRELEVQLKTTTDRGLAQEAHFNVTTKEMSQKFNLALQQATKKAEQCDKEKNEAVVKYAMREGEMMKLRDEISKKDSNMKVIKEELEAARKAQDDLEKTVQNLKVEIEKLKHERFDFENRMKRVESLSSNLSESKQQGDMLRKQLIQAKDDKHIIQQYEVKLQTSTAELERRLRESEHDVERLRTSQLEATKFEEASRENTDLLSKIDILQDQLSLEEDRRKLCEEQIDRLKGVESFVESSSHRIEEERETAEEDREQAELEAAEYREQVEKMLKLTQELTERNMELQRKLKDEEGKNTSHNSTIEKLQVELTTSLELCKSFEETNLKISEELENLKTEMQKPVTLESLEENFYRDKYDEASRKLEQTEAKLAEE 490
25 -16.300[R] KOG0567 HEAT repeat-containing protein  ali follow..  10  3..................SQQQIEAIGGVLNNKERLKERFRALFTLKNIGGG-------AAIEAISKAFDDD--SALLKHELAYCLGQM------------------------------DAQALDILTKVLKDTTQEVRHEAAEAMGAI-------------GHPDVLPILEEYKQDPVVEVAETCAIALDRVRWLQSGQKV-TAGDKSVTELKAIYLDAQ--QSLFDRYRAMFSLRNL------------TEESVLAIAEGLKDSSALFRHEVAFVLG--------------------------QLQEPCSIPFLQENLEDRLENEMVRHECAEALGAI--ATEDCIQILNR-------------------YAEDDKRVVKESCVIALDMC.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 281
26 -16.200[UR] KOG4677 Golgi integral membrane protein  ali follow..  13  149..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NDSSPNFKSQLFAKDSQISVLKTKLSEVERKFEKRSQDYYEMKAEKEMLEKRVSHEMDSLQELKLARQKAQDQKEKAVEECNMHKRKIVGLEEEVEQLRLAKFNLNENKKEFDEYKNKAQKILTAKEKLVESLKSEQGIGSSDRPVHLLQAEVEEIRVERDLTKADLESAQLQVYTLRSDMEELEAQIRDLQSQLSD---QKRTHLEEKQTWDSTIGLLNEKVECSRIENEFTKQEMKRQGSKMLEKENELRKTISDLRSRDEQTKQEDDGSSQLTDLLLQKQQQLEDVLRNNQVLNVRLERLQKATNRETSIAVDSNS......... 480
27 -16.200[S] COG1511 Predicted membrane protein  ali follow..  32............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SGVFLKAYWVDQLPVVV---VNQDKGATYLVKELKDNNNDLDQSLKDLLVVEI---LKYHTNAGSNYVGATIGEKAIDKL-KASVSKEVTEQYTKVIFDNFKDIAKGLSDASSGA---KKIDDGTKDAKNGSAQLKENLAKLKESTATISDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLAGLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKDLTKLETAVNNLEKSETAMKEFKKQLTDFENSLKNRDQAFKNV--INSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEGADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSKQVQSGSSKLADGSASLDTGLGKLLDGTGELSSKL 542
28 -16.000[ODR] KOG4151 Myosin assembly protein/sexual cycle protein and related proteins  ali follow..  442TPIMLEMAASQDHLMQGI-------AAELIVATVSKHERAINMLKLRALYDSEDPTVKVRALVGLCKI-MKEEAVISLAKTCKKFLLETEKYSVDIRRYACEGLSYLSLDADVKEWIVDDSLLLKALVLLAKKAGALCVYTLATIYANLSNAFEKPKVDRALVEEGAVPACVAVSKTESKNALELIARSLLAFAE-YEDLRGRIIAEGGTVLCLRLTKEASGEGK----IKAGHAIAKLGAKADPMISF---YEVVKPLCDLLHPDVE--------------GKANYDSLLTLTNLASVSDSIRGRILKEKAIPKIEEFWFMTD-HEHLRAAAAELLLNLLFFEKFYEETVAPGT----------LKLWVLYSAEVEEERLSRASAAGFAILTEDENACARIMDEI------------KSWPEVFKDIAMHEDAETQRRGLMGIANIMHSSNKLCSEIVSSEV-----RVLVAVTKLGTINQERAGSTEQAKRGLEAAEKFIKATDREIYERENQMSTIQ.......................................................................................................................................................................................................................................................................................................................................................................................................................................................... 960
29 -16.000[DY] KOG0977 Nuclear envelope protein lamin, intermediate filament superfamily  ali follow..  11  39...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EKQEMQQ-LNSRLE--VYISRVRQLEDRNKELVIERGSLGNDIGQIKFKFNDSLVKVRREISEAHSGTIGVEVKVDRLRDDLNDYRHRYEEARREVEREKTTWGGAISQAQAELDTNKSRYAAILDEEKRLYAEQDQLYLQLAAAKDELDAAIVDRRRLQAEEDDLKIELEFLGRISQEITELRTLLAQAPADTREFFK--NELALAIREIKAEYDKIIQTTRVDLET---QSKISAVESSIVSKNEAAVFRQEEIRKMNESITTLRAKLSELEARNSALEREANTLQIQ----------LGEDQRAYESELHKRDNALRFMREDCQTLIAELQALLNTKQTLDTEIAIYRKLVESEEGRLV......................................... 389
30 -15.800[D] COG1196 Chromosome segregation ATPases  ali follow..  13  484.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QQMKSRKETLEELADDYAGFFQGVREVLKAKKEIPGIHGALVELIDIPAKYQQAMET-ALGASAQNVVVEDDRVAREAISFLKKTKSGRATFL--LSTIQPREL-NALSNQPAFIALASEVISFDQKVSPVILNALGTLAKDLKGANTLARLVNFRYRIVTLEGDVVNA-KSSILTRKHELGQLAEKIAELNNSTRELESAVQVAKDSMSKKREELEETRVIGENLRLQEKELLGKLDRETENLERFNKQLQLYDIEKADGSEELNKLLERKETLLQEQVEIAKQIEKTDE--EIKAMTSSSKALESKRTADLESLSSLKAQIAAKREQLQSAVEAVDRVTTTLHENYEQKEAAEQKLASLKTNLSSVHTSEESARKSIEELRKDKAETSEKLNQTRQTRTELQEKIELLEAELTQKNNQISFYVEQKNNAEISIGRLEVDITNRIDRLQEAYLLTPEQAEQARSKVRLLKRSIDEL 983
31 -15.800[S] KOG1949 Uncharacterized conserved protein  ali follow..  18RRFLSCLFNWNINFIKMI--GTIKNQLQGLQKSLMVYIAEIYFRAWKKASGKILEAIENDCIQDFMFHGIHLPRRSPVHSKVREVLSYFHHQKKVRQGVEEMLYRL-----------------KPILWRGLKARNSEVRSNAALLFVEAFPIRDPNLHAIEMDSQKQFEELYSLLEDPYPMVRSTGILGVCKITSKYWEMMPPTILIDLLKKVTGELAFDTSSAD--VRCSVFKCLPMILDNKLSHPLL---EQLLPALRYSLHDNSE-----------------------------------------------------------KVRVAFVDMLLKI--------KAVRAAKFWKICPMEHILVRL-----ETDSRPVSRRLVSLIFNSFLPVNQPEEVWCER-------------------------------------CVTLVQMNHAAARRFYQYAHEHTACTNIAKLIHVIRHCLNACIQRAVREP----------NDVACMAGLLEIIVILWKSIDRSMENNKEAKLYTINKFASVLPEYLKVFKDDRCKIPLFMLMSFMPASAVPPFSCGVISTLRSREEGAVDKSYCTLLDCLCS-----GHILELVDNWLPTEHAQAKSNTASKGRVQIHDTRPVKPELALVYIEYLLTHPKNRECLLSAPRKKLNHLLKALETSKADLESLLQTPGGKPRGFSEAAAPRAFGLHCRLSIHLQHKFCSEGKVYLSMLEDTGFWLESKILSFIQDQEEDYLKLHRVIYQQIIQTYLTVCKDVVMVGLGDHQMQLLQRSLGIMQTVKGFFYVSLLLDILKEITGSSLIQKTDSDEEVAMLLDTVQKVFQKMLECIARSKQPEEGLRVSDVEELTPPEHLSDLPPFSRCLIGIIIKSSNVVRSFLDELKAIILVINAGKHKSSKVREVAATVHRKLKTFMEITLEEDSIERFLYESSSRTLGEL 885
32 -15.600[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  14IQLLQHAHSTDRDVQRNVQVQYLVYILSDMKEMIDATSRSLAGLLLKNNIRAKWNKYPQDVKFFVRTTCLKGDQEPLIRATVGIIVTTIVMEENMCD-----------------------PDLLDTLATVLMQPDELMQEGALGALQKVFEDSADRYESEFLRP---MPKLLVFYEHHAAKMRALAMNCVNCILMVNND-----PIDFAIDQFLTSLFARHNDNDEEVQKQLCRSLTLLLDTHIEKMMPHLPN-VIEYIIKKTQDHNESIA------------LEACEFWLSIAENSDICRTMVLPHLDK-LIPVLLGSMRYSETDPNIRRCSAASLDVLAS-------------IFGKDLLDKLFPLLKDTL-MNDNWLVKESGILALGAIAEGCMDGVVPHLGELIP--------------FMLAMMFDKKPLVRSITCWTLSRYSSH----------IASDENFRQQFFKDVLANLLRCSLDGNKKVQEAACSAFATLEEEAGEQLIPFLGE------ILDQLVKAFQCYQAKNLLILYDAIGTLANSVGDALS--HPVYVQMLM------PPLMEKWERLSDEDKELFPLLECISAIVSAMGQSFLPYIQPVFTRCCSLIEKCVQQNQQHIMAPDQVEAPETDFIIVALDLLSGLAEPEHMDPLVANSKLVELMLFCSLDVTPDVRQSCFALLGDLTKACPERVLPQSSNFIFF--DPSKISVCNNAIWALGELALKMGPAMKQFIGPIIEPLIVVINSQQNMQRTLLENTAITIGRLGQCCGEELAPHISRFVRPCCYSLRNIKDNAEKESAFIGLCNMINMNPVGVLNDFIFWCDAIASWTVPTDSLRVLFAGILQSFKQQVGD-FNWNNFILQLPPPLRERLSAFYQI................................................................... 883
33 -15.400[Z] KOG1850 Myosin-like coiled-coil protein  ali follow..  12  136.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKEVLLLMQALNTLSTPEEKLAALCKKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNKTLKEEMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEKRKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNEKVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSH. 486
34 -15.300[R] KOG4678 FOG: Calponin homology domain  ali follow..  11  280.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SPNSVSELSLASLTEKIQKM---EELQATLQELSDQQQMVQELTAENEKLVDEKTILETS--AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCT----GILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR---VTLEGLKMENGSLKSHLQGEKQKATEA--------SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEIC---DHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARL 682
35 -15.300[R] COG1579 Zn-ribbon protein, possibly nucleic acid-binding  ali follow..  10  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MHDALLSI--AIQELDIKMIRLMRVKKEHQKELAKVQSLKSDIRRKVQEKELEMENLKTQIRDGENRIQEISEQINKLENQQAAVKKEFNALTQEMTTANKERRSLEHQLSDLMDKQAGGEDLIVSLKESLASTENSSSVIEKEIFESIKKINEEGKALLEQRTELKHATNP. 173
36 -15.100[D] COG3096 Uncharacterized protein involved in chromosome partitioning  ali follow..  12  660..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IERLSQPGGSEDQRLNALAERFGGVLLS---EIYDDVSLED-APYFSALYGLSQVTEHLEGIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLN-ADDSLADRVDEIRERLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFS---SDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADS--GAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDN.... 1127
37 -14.900[U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit  ali follow..  12  15...IFELKAELNNEKKEKRKEAVKKVI-NCMQTDNLELKKLVYLYLMNYAKSQPDMA-------AVNSFVKDCEDPNIRALAVRTMGCIRVDK-------------------------ITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQ-----MVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTE-----GQIFILDCLSNYNPKDDREAQSICER-----VTPRLSHANSAV------------VLSAVKVLMKFLELLPKDSDYYNMLLK--KLAPPLVTLLSGE--PEVQYVALRNINLIVQKRPEILKQEIKV-----------------FVKYNDPIYVKLEKLDIMIRLA--SQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNVQEAIVVIDIFRKYPNKYESIIATLCENLDSLDEPDARAAMI-----WI------VGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPD................................................................................................................................................................................................................................................................................................................................................................................................... 518
38 -14.900[S] COG4913 Uncharacterized protein conserved in bacteria  ali follow..  27.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VVNWGTFNTRVWCYTLGGRSGL-----LTGDIGSGKSTLIDAITTLLVP---AYNKAAGADARERSLRSYVLGYYKSERILGVFHNVGYDKVITLAQVFWLKDSQSQPARLF------VVAERALGIAADFNNLGGDIKTLRKKLRGADSFPPYGAWFRRRFGIQHEQALELFHQTVSMKS---------------VGNLTDFVCSHMLEPCDVGSRIEALICHFDDLDRAHQAVLTAKQQVKLL-VPLVDDVQKHQTQLASIQALEA-GRDTLRPYFAQLKGELLKHRLDALAAEAAQLTVEIQHLEEQRKAADSEVTQLRQALRDNGDRLEELAAEIEQLEQAKAQRQKKSDRYQTLLTKILTQQQRFAQHTEELNAAIERLHNDKSEKDRALYDAREKHTTLLAEINSLQQRQSNISAAQIRIRHDLCMALSIDAEALPFAGELIQVRKEDARNWEGAAERL 501
39 -14.800[D] KOG4593 Mitotic checkpoint protein MAD1  ali follow..  11  56................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HLCTY--QCRQMVKDVLDA-------LSTAEKQVEESKTKLQTL--------------------NANFTEADAER---KHFRDKFLYSEQELAAAKAREKMLQEQLLMEINNSQERYTKELQELEVKLQNEMNLRKKAESSAATAEEKAKLLEDKLTQLSGSVDREKKRLNDIAQLGKEAKLSVARIGADLERMQCRAQNAETESNLLRSQLEHLKLIFDECLQEKTEVDKKLSSFTSEASDNSVLVKHLQEELKRYEAEVREARKLKSRHLDAELLNVNLLEEQSRRERAESELSKFHDLQLSMEKLENELSSWKSCPDDIVMRFSVLQNEVVQSTMKIGEASTRIKQLEETLEAIQLGRQNAVSEAALAKEKSEALKTDVKRIEVMLTLVTEEKEQLKAVVNELRKSNSEGSVSGAADGALIQGFESSLAKKENYIKDLEQDLNQLKDVNNRQRTEIELLNEKL 506
40 -14.600[D] COG4477 Negative regulator of septation ring formation  ali follow..  12  2.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSTVIILIVVLLVILVAFYA-------AILMRKKTEDRILA---LEERKESLFDLPVQEEIDSVKKMHLVGQSQTIFREWNQKWLDLSSNSFADLEEHIF-----EAEQLNDSFHFFRARESVADSEAQIELMEGDVEGIRQGVAQLVEQEKRNSNKIQESLDLYDNLRSDITELEKHLANIETEFSQFVTLNSTGDEAAEVLETAEEHTIALRAITEQIPSFIKTIEKRLEELQEASDKFVAEEYILPDNVNIKERMDDLHDHLVESSSLLEQ---ELDRVEAELGLIQEKVEELYAIFEREYSARRNVEKRSSVLKEYIEHIRANNKNLLLEIDHVTGYVRGYQEHLESLDSDVDEILGNIQAKTMPYSILSRRVNSVVNALEDIEKNQIKISDTLTGLRDEERAAQEIAERFDSELRTIKRYVEK..... 440
41 -14.400[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  1.................MTSDIAMQLIAILEKSPDKNELLSAKNFLEQAAASNLPEF----LKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQTENTRPSCAAQCVAYVAVIEPMLIQTLVNKVVSEGSSHRESALEAIGYICQDIRFGVMENQSND--VLTAIIHGMVEPSNHVRLAATTALHNSLE----TKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQ-------EPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDE-WSPAKAASVCLMVLATCCEDEIVPHVLPFIKEESPNWRFRDAAVMTFGSVLNGLETNT----------KPLVEQAMPTLIRLMYDSSV-IVRDTIAWTFGRICD---------------PEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLS---DAAWEAAVTNDGETPETYALSPYFEYIITQLSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQR---TLVILERLNQVMQMETQILQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNQEEAFLAVSTLVEL---------------------LGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNE----MTVLINNLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSM--LASAAGFIGDLCTSFGPRLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKINTQVIT.............................................................................................................. 883
42 -14.200[S] COG5280 Phage-related minor tail protein  ali follow..  10  15............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DTTGVTNGLKDIGKQSNSVNSELRDVERLLKLNPNNVELVAQKQQLLSKQVELTTKKLDGLKGAQADVDRQFKSGDIGEEQYRAFQREVVATEGRLDHYKQSLKDVESSSGEAGNATKGLGGKFDELGQSVEDVGEAVKGGVLMEAADEAFSDVDEGMDKITTTTGKASDEFKTQFDNIEDVGSALGTLSAQFDMSGDTLEKNSKLATDVKTSIESAKSAIEAYGLSNKDFSTVLDSVTATSQRTGVAVDSLFDSAVKGAPQIKDLGLNFSQGTELLGDGDAALSSLSKASIIYAKGNKSLSEGLGETIEKIKNAKTKQEA..... 376
43 -14.200[U] COG5096 Vesicle coat complex, various subunits  ali follow..  1.............................MSCWTLVQQDFLEAPSVDALKTSLESKNDYVKISAMKTILRVVINGDSLPSILMHVIRFVMPSRNKELKKLLEVCPKYNNDGTMKQEMIL---ACNSFRNDLQHPNEFIRGATLRFLCKL---KEPELLDPL------IPTVRQCLEHRHAYVRKNAILAVFSIYQVSNH-----LIPDAASLAEDFLAAE---SEGTCKRNALIVLFTIDPEKAKA--------WLLANFEQIPSLNA-------------SLLVIIEFIRKVVLTKADGLEKLRFQ---------LLVSLTATNNSSVVFEAATSVINVFPDAES---------------LKLAASRLLALADREADNNAKLIMLDRISQLAARDKSILEDLITDVIPFLSS------------------------------------SDFDVCEKAISIIMGLVSSRNVEDILNHFQKELTKSNDDGRRRALTKAIHSCAINFPHTAATAIQASSVLSFIKEVMEKFPDLRSSNITKLLLSL------------KELRAGKIFRGVIWIAG--EYCLTEDDIRV-KSIRASLGEVPILASEEQLLKDVSNVPEDDLLIDISAPASTSRKVLPDGTYATESAVTSEALSAARLEAVKASKKPPLRTQILSGDYYLAAVLASALTKLVMRFARLSFDKERLNALKAEACLIMTSIIRVGQSKFVKYTIDDDSVERIMNCIRAIYSFEELPEFQTVFLDDMRKAFSSLVAQSDKRQKEADLLVNGSDAVQADELLNIRQFQRVIEEKQDLNFESDIIQATNDGMVVEDLASKLDH-VNRTDTTLQNLSVDLATLGDLKVVERPPPMNLGHAFKSVQATVKVSSTESAVIFGNIVGGKASDEDKIVVLNGIPVNIIDYIKPAFIPESQFRSMWTEFEWENKVDISSNEDISLYD.......... 864
44 -14.100[U] KOG0993 Rab5 GTPase effector Rabaptin-5  ali follow..  13  534................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEK---LKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRKLSQTLQVQLERIRQADSLE 842
45 -14.000[R] KOG2295 C2H2 Zn-finger protein  ali follow..  179........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVKRSEEQRGFLQRRTD---------VFMELLENTIGSVKVDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSISITRSEIEAVCNRFSMRDVNIKEICWGLNNMGAIVNRDLSRRVRPANGITAHKQVVRSDIKLC 618
46 -13.900[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  555LDGFFRWSQHCSNFNKESMLSLREFIMKALASTSR-CLRVVAAKVLPIFIKLDIVEFHKESKALIFNTLKIAVENTAILETVILSWISLSRVVEEEELHFV----------------------LLEVISSVINSGIFYQGIGLSALQQIASTRHISVWQLLGKKPNIASLFAQLMNISEGDVLTKNKALIVRIAELSQSDVATLCLTNMHKILASLLTTDHPNLEESVMLDPISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEKMLLCGGAVKLGLPQILSNLQSAFQNEHLRFYAILATKEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFISSDTHKCLQGLKWAI--FCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAK---VDELHDTLNLDISNEVLDQLLRCLLDCCVKYASTNMQISYLAAKNLGELGAIDVLDNFENGEESLKFILDFMQSQLVTTDTKAQGFLAYALQEFLKLGGMSLPDLSKRVLIPFLTSKYHLTPLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLVLNVIELEVNKVIEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRATSRESSISKVESFLSRFPSKLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAGIDDPDEHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQHYESLVLSLDSFIINDNHEYSKMLNLGIEASWRSLSIDSLKKCLSKSNLESFEAKDSFAELTERLQPLYVDATAIANTGAHSAYDCYDILSKLHAI-NDFSRIAETDGIVSDNLIVLRRRLSQVAPYGKFKHQILSTHLVGYEKFENTKK...... 1657
47 -13.900[K] KOG0963 Transcription factor/CCAAT displacement protein CDP1  ali follow..  11  11...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLTESW---------RFEELQREADEAAAEIEKMQKTSLDERKELSSKT-----EFRKQPDEV-KLGEMKGLLKL------YQSGIDSLTKRAKSA------------------EATFFRVYETLGEVLLIEAANNLKTQKQIEDLKKEKEEMEGSLQGKEKLEREVENLRKELDKYKDLVETEAEKRAAITKEELEQQKLYKDMEQENASTIQKLTSKIRELQASQLDHDLQASQNESAGLDVNAKSAEVNAILSELDDANKIIVELQAEIAVLKQNTKEQKSGSSQDDLSNQQKQQLDFMDSLNKKLSTELESIKEASRKEMETHCA---TIQTLENEVKEARKVKEESLTLANK-FSDYDEIKRELSVLKQIEFSGEHATHENTSLESQLLKREKQLSEELAKLRSTNAQLTDRITQESKKASFLEQKASEQEEVIRKLEKDLADVDVEGSVYLSNTT...... 442
48 -13.800[S] COG3883 Uncharacterized protein conserved in bacteria  ali follow..  23........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TNVFADVNTDIQNQDKKINDIKSKKTGLQSDLSSLVADLEKAQEKAKSLQGEFDQTGKELKQLNQDIKDINERIKERETVLKERARAMQKTSNSNAYLESDLVGRVSAVNQLVDSDKSILEDQQKDEKALKTKQTAVKKKQEEQATAIHEFEAQQNKIEAQKAEKEAIVAQLAADQAS........ 208
49 -13.700[D] COG5244 Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B  ali follow..  12  355.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ISNVNRYLNIVPGSLDLQFSLTNENFVHWNSTVYQELLNLKSNNSSVDGVKTRRQLLEENALLSHKVLKLTEEIQDLETLNQLNTEIARQSEKLNEVQEETQRLSQLLISSQPALTEVKHLKLCLSDSQEELLQLNAKLEKANIVIDELNSAKLKLSKQVEEESSMKDDLTEMNQRLKEQIESYENEVNSTSRTLKEFETLKTQYEKNLCNLREQLKTARMKLADKYPQGDNTSENIDWLKHSLRDSNTELTFACKEIRKLVADIKPVSVEKQ--KKDIERPSFHHNQQLDIL 666
50 -13.700[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali follow..  10  101CQIIARVVNCVKEIDDDLYNTLKEKLLSRVLDRE-SIVRLEAVVALSRLQEDTGDE-ENDVRNILLFLLQND-PSSEVRRSVLLNIE-------------------------------VSNSTLPFILERARDVDAANRKCVYARVLPKIGDFRY------LSIKKRVRILKWGLNDRDESVEKAAADMLAY--------------ENADNNLLELLERLDVSNNSDVAVLAIKKFFDVRVDEKNYTDLLDKMPEVVQLTYYIERQYVSLRDKSSYDESCFIIEQLLYIG-----------DMVDEIGRRKLLKSLTNSLSTMALPDSLISLHIELLRKLCSSENDFCSLLVEISPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSYVQCLFENITSSLNDMLKTLIIPAVRSHDLPIREKGLECLSLV-NADLAFENVPLYLHCYEKGSVVLKCTAIRTKFTEYEDAISSILFEALGEFENAELQTLGAEAIAKLL----------VILHYRDELFLKPLIIQYFEPNTVDNHALRQVLGYFF--VYAFGAHENQWRIATIFCDALLVQLSIGHIAQQMLDWTDNEKLYERKTQTGDDYIALNHNVHLHLANMIFESLPN----------------ASEGKERKFMISLLGKLKIPTDLPSSDYQRTKRKLETYESHGFTMDSTSLSILAKFERMLLQN--EEARSKFEETEEERLMENAEENEHAGAEAISGEIIPDTVEANMEDEEEVYVKQEEDL.......................................................................................................................................................................................................... 875
51 -13.600[O] KOG2160 Armadillo/beta-catenin-like repeat-containing protein  ali follow..  15  127................................................................YKEFQKNFRTDGELIVQLIDQFRNFSRTPLESEMRSK-------------------LDCLENLEYLLHQIDNALMFIDNGGLDDVL--------------------LPIVVNDTSTSLRVSAMRVLGSLASNNPKAQIKVFEKNFGSHLAQILTSS---GNVGEISAALHAFGALLRKFPLAQQRVLSTSGTQALIKVLQSPDVELRSKAK-------VVTLISDLVLEKRSVLDLLDFESWLKTPGYCAAVDTVLTKEFLQPEVVEQFATALETTED............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 375
52 -13.500[S] KOG4725 Uncharacterized conserved protein  ali follow..  10  67...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TSSATLKDLESPCQEPAVVPDSRSVKISQLKNTIKSLEKKANEKQKAERELEVQIQRLNTQKGKLNMDLYHTKRSLKYFEDESKGLAIRLQHSLQRIAELERALFAVTTTQEKKEDSVHTLKKEKYETHRGEKLERSLSKLKNQMAEPLLPEPPGVPSEVELQHLRKEVERVAAELQAQVDNNKRMSVLILGQKERLQEQDERLREQDARPQQLELNKNKSALQLEQQVEELQEKLGEVELKSREAQSLQQHPDYYLGHLQQYVATCQEQVAAYQQLTSEEALHSQLLQQTQLMNQLHQQEARGKAIADLARQNQQNQPLQA. 397
53 -13.400[U] KOG1077 Vesicle coat complex AP-2, alpha subunit  ali follow..  3.....................GLAVFISDIRNCKSKEAEVKRINKIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK---SEKQIGYLFISVLVNTNSDLIRL---IIQSIKNDLQSRNPVHVNLALQCIANIGSRD---------MAESFSNEIPKLLVSGDTMVKQSAALCLLRLFRSSPD---IIPGGEWTSRIIHLLNDQ----HMGVVTAATSLIDALVKRNPDEYKGCVNL-AVSRLSRIVTASTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEVVILSMKMEKDVSVRQMAVDLLYAMC--DRGNAEEIVQEMLNYLETADYSREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYIQIVINREEVQGYAAKTVFEALQAPACHEN----MVKVGGYI------LGEF-DSRSAPLVQFKLLHSKYHLCSPMTR---ALLLSTYIKFINLFPE--IRTNIQDVFRQHSNLRSADAELQQ----------------------------EYLQLSIVASTDVLATV---------------------EEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRY-----GTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKVFK--AAQPLDLPGARNKLMGFGMQLLDQVDPNPDN.................. 880
54 -13.400[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  7...................GTRLRDMIRAIRACKTAAEERAVVRKIRALINEDDPHDRHRNLAKLMFIHM------PTHFGQMECLKLIASPG---PEKRIGYLGLMLLLDERQEVLML---VTNSLKQDLNHSNQYVVGLALCALGNICSAE----------ARDLAPEVERLIQFRDPNIRKKAALCSTRIIRKVPDLAENF-----VNAAASLLKEK----HHGVLITGVQLCYELCTINDEALEYFRTK-CTEGLIKTLRDITNSAYQPEYDVAGITDPFLHIRLLRLLRVLGQGDADASDLMTDNAVLYECVETIMAIEDTNSLRVLAINILGRFLSNRDNNIRYVALNMLMKAITFDDQAVQTILECVKDPDASIRKRALELVTLLV--NENNVTQLTKELIDYLEISDEDKEDLSAKICFIVEKFSPEKLWYIDQMLKVLCEAGKFVKDDVWHIVVISNASELHGYTVRALYKSVLTYSEQET----LVRVAVWC------IGEYGDLLVNNVGMLGIEDPITVTESDAVDVIEDAI-------TRHNSDSTTKAMALVALLKLS-SERIKDIIVKQKGSLLLEMQQRA---------------EYNSIVDRHKNIRSSLVDRMPVLDEATFNVRRAGSF--------PASVSTMAKPSVSLQNGVEKLPVAPLVDLLDLDSDDIMAAPSPSGTDFLQDLLGVDLGSSSAQYGATQAPKAGTDLLLDILSIGTPSPAQNSTSSIGLLSIADVNNNPSIALDTLSSPAPPHVATTSSTGMFDLLDGLSPSPSKEATNGPAYAPIVAYESSSLKIEFTFSKTPGNLQTTNVNLSPNTFTDFIFQAAVPKFQLHLDPASSNTLLASGSGAITQNLRVTNSQQGKKSLVMRMRIGYKLNGKDVLEE..................................................... 866
55 -13.400[Z] KOG2685 Cystoskeletal protein Tektin  ali follow..  11  94........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ITCDQEKLAERIVEESRRVVDETKDTTKNWQREVEHMRERTSEIRFLVDELNRQKKTAALEDEALNTYRNRVLNCIEFLKDKSLAICKQCLILREGRIGVDSLRRELKVIKGCQGLADAALKEAEEQIRKLRAAIYLLDQDLAAKDKSLAIDEKNLKLKEFQHDLYENLEANAKALVSAGQLRAYIDLLLKQVCEDMQNQTDRTNAFERRISETKHVKQCLENKHKDTMDHIHQVQRNMTELEKEMMDKQRAITLCQTRLSNRAHRLELTCDMVQALYNELQALKASVCKLNQKLNENKASMRYLMHVQVMQEEEINIKANTCKIDEVDC 458
56 -13.200[S] KOG2973 Uncharacterized conserved protein  ali follow..  2.............................................................................................................................AIFGLTFDANQTVAKDAVLSLINLTSEEE-QLAKQLQPPFAIVEVAAKEITNEQSDLADPWSMVLSNLTRVESLVHEILRDDHTLPRLAKAFAQLDYNKKKAKLHYLAPIFCNLTQVSRGRELCCHKYELLEKLLPFASFEGSVVRRGG--------TIGILKNVCF-----DTVYHDVILNEQSSILVAILQPLCGPEEDPDLRKMLLECLLQLCS-TRRSREILRSRGV-----YEILREYHKWEAKVGKDSDCLLACENVVDILIKKEEE.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 289
57 -13.100[S] COG5283 Phage-related tail protein  ali follow..  2................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ADIMVDSVTTGIDLN----------------------------------ETKAVEAINRLKSAVKDSTREWQINEAQAKSAGDAVSASKYRYEGLSEAMEKQKAYIANLSEGMKTINRNTDAGEKAYQKYNAQLTTAERSLASMTGQLNRAKSAYEYQQTGIEDLNKSDKLMQSQIDLYEKTRNKMGAAKAEVSGLSTSYAKQTEIYRAQVTELKREAAEGTSSETLVKQKTRVNEAASSLMNYRNKLLEANLAVTKMQPFESLIGKGLNTVYQTTEKATDVMAAGYQKVKSAAYQSAELQNQYKTTFNLLVTGGEQAKEAQENVNKMQEQGSELSVKYGKTQKEIADGYQELIKRGYTSSQALAALPTMLQASVASGDDFTDVVHNSTAALESFGMRSNDV 394
58 -13.100[U] COG5240 Vesicle coat complex COPI, gamma subunit  ali follow..  10  41RRLLSKIAYLIYTGEHFQEKQATELFFGITKQHKDPSLRQFVYIIIKELSVVAEDVI------ITSSIMKDTATGREYRPNAIRSLIRVIDAN-------------------------TVPAIERILTTGIVDPISAVASAALVSAYHLYPVAKDIVSR--------NNEVQDAVTSHNVGRKVASSPFFTSTLGYTPNASGISQYH--ALGLLYRIRRHDSIAMNKLLQLLIRYISSLMDQNTQFRDQMVPF-----LHGWLKSKGDMV------------NLEVARNMVRLKNISDDDLQP--------VVSVLKIFLSSHRS--ATRFSAIRTLNELAMTRPHLVHSCNLN---------------IESLITDVNRSIATYAITTLLKTG--NDESVDRLMKQIVTFMSDISDNFKIIVVDAIRSLCLKFPRKQDSMLTFLSNILCDEGGFKRAAVDADMIKYIPESKERALAELCEFIEDCEYPKIAVRILSIL-----------GEEGPKASEPTRFIRYIYNRIMLENAIVR---SAAVSALTKFGLNAEDKFVQRSVKVILTR........................................................................................................................................................................................................................................................................................................................................................................................................ 537
59 -13.000[S] KOG0212 Uncharacterized conserved protein  ali follow..  12  66LIGLAAVAIALGPKIDSYMESILLPVLYCFNDSD--KIRYYACESMYNIGKVAKGEVFR--FNLIFDVLCKLFADTE-VKNGAELLDRLIKDFKEGPVSSSIQDVPVMSTEQPRMHTFSLSELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDLEFISYL---PFLLDGLMNYLSDPNESIRIVTSNCLYDFLREIQKIAKVKYHILQYKRILEIIIDHLGSSVPLIQEKALKWLFEFIYIAPKDVLLQIPK-VLENLLPLMSNDENMRQSAKDLSQNLVILVSKIMDIEFSGSETNNKDNSLSVDFRS-LIEVLQKLLSNDNE--ETRLCALEWVLLLQRRTGGKLINMHD----------PIFQTLLLQLSDPSD-LVVSRTLELLAHIAISHKSVNVPFLKSLLQMFAEDRKFLNSRGNLIIRQLIEGERVYTSFAGILLNNNLFTAPELYDLRKKLK---QSAPKLQNIFTTLYTAWCHNSIAVFSLCLLS-LLSVFAEIEFNIDMLIQ----LDKLVQLIESPPEKYPYLHKALYGILM-------------LPQSSAFRTLRDRL----------QCSSTPRTNTILANERLPRSRRDDPYWT-DLLERLKAVQLSHQNNYREPIRATRLALAGALPSTPTAT........................................................................................................................................................................................................................................................................................................................ 769
60 -12.900[S] KOG1043 Ca2+-binding transmembrane protein LETM1/MRS7  ali follow..  309............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DALSSIDLQSACRAR-GMRAIGVSEERLKEQ-----------------------VQWLELSLNDKVPLSRTLYLPEEVSFPDRLKAIVQNLPDGLAETTKQKLTEMEGGQIDHKARIELIRSIESAIANEKKDEEKKKKAAEEALKSKEEAEKAKVQEKEKLVDVAHELKKDIYDAVASTSSTTEAKEPAAKPSEAKEEKKEDITVDKKDLSHIEEIIVGGPIKEAKHDILGLREKVLEHKEDLMEINSLDGAFAETKIAKLRHKLNSMIEDVDSMVDKLEDEKRNIREMLIDPTVENSVDLKKEREVR---QDVIDSLAKLKESKGEQADDGEQRERIEALLKTIDEDKQLVLEVIEEKHTDVHVSAAQMASMIGTLKKEDEVAGLTEEIRKVQSGNYQMPILP. 707
61 -12.900[S] COG4694 Uncharacterized protein conserved in bacteria  ali follow..  11  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MIVCINRL-FGIFNDFNGTKIQKFGRYNLV---WNGTGKSTLSNLFSCFELRSM-GSTITEATLHSCQLNIHVFNQRFVH-WDKSVKSILLIAKEKIDDLQKLEKLKGELQSKRKARDEKQGEVKKQREALDKFLTNAAK-RRKLSNFIQSNGEAIIKADSILSDDKVIDLTNAAKPDQLPSINFVSTSIEPDYFKKASGRIRDLIGTTAVNQAIQRLTDNPDIREWVQTGLEIHKNHESSTFTQLRAEALAAHFSKEFTDFQRRLQNAATWIESQGAPANQLPAATEFYKELSAEADKLQKDYATAAEKIDKQMDGWREALKAKITDGKTDIQISDVVEDDVKNFNEILKSIVALVGKHNNKTSNFKSETSKSKVALAGSEKKCNDLESEAKNDHKEIEKISQEVGAIEALLSNETVGAKEFNDIL 485
62 -12.900[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  66............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DVSHIDVGSLQEQLDNAMLSMKMVEKERNKDEQQIRDLKETQKKCLKTIAGLEQKVQKKDFLISSYVEQIGVLKSDAHVVDGLRKENKTLKSQIQSMEGISAILAAGSADADRLLKNEADPHVLANWVSTLKRELRQCESKKTELRNVVKVVQNDLRKEIELKRYAHNIPNVVF-IIDMCSFDCSKLEERVSHLESDLYQAQEKLQAFENKTAYLDSPNASCGLNSNILALKREERRTTISPTVKENIKRIEESTSPYLNIKSSSVGLAHLLNTKGNIGLAKSKISPIKGVGGGVSMTSGTIRKTSSD.. 372
63 -12.800[S] KOG2701 Uncharacterized conserved protein  ali follow..  12  255...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TSQLHRRKVISLNKQIAQKTKHLEELRASHTSLQARYNEAKKTLTELKTYSEKLDKEQAALEK----ESKADPSILQNLRALVAMNENLKSQEQEFKA------HCREEMTRLQQEIENLKAERAPRGDE--KTLSSGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIRLLQARRNREIAILHRKIDEVRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLEKELNSIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLELLEKQRLYFKTVKEFKEEGRKN-EML 566
64 -12.800[M] COG3264 Small-conductance mechanosensitive channel  ali follow..  11  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MRLIITFLMAWCLSWGAYAATAPDSKQITQELEQ-------------------------------------------AKAAKPAQPEVVEALQSALNALEERKGSLERIKQYQEVIDNYPKLSATLRAQLNNMRDEPRSVSPGMS-----TDALNQEILQVSSQLLDKSRQAQQEQERAREIADSLNQLPQQQTDARRQLNEIERRLGTLTGNTPLNQAQNFALQSDSARLKALVDELELAQLSANNRQELARLRSEL--AEKESQQLDAYLQALRNQLNSQRQEAERALESTELLAENSADLPKDIVAQFKINRELSAALNQQAQRMDLVASQQRQAASQTLQVRQALNTLREQSQLLGEALRAQVARLPEM-PKPQQLDTEMAQLRVQRLRYEDLLNKQPLLRQIHQADGQPLTAEQNRILEAQ 382
65 -12.700[D] COG4942 Membrane-bound metallopeptidase  ali follow..  12  39...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SAHADERDQLKSIQADIAAKERAVRQKQQQRASLL---AQLKKQEEAISEATRKLRETQNTLNQLNKQIDEMNASIAKLEQQKAAQERSLAAQLDAAFRQGEHTGIQLILSG--EESQRGQRLQAYFGYLNQARQETIAQLKQTREEVAMQRAELEEKQSEQQTLLYEQRAQQAKLTQALNERKKTLAGLESSIQQGQQQLSELRANESRLRNSIARAEAAAKARAEREAREAQAVRDRQKEATRKGTTYKPTESEKSLMSR......... 295
66 -12.600[KT] COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription  ali follow..  5.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSLFTLGKSFISQAEESIEETQGVRMLEQHIRDAKAELDKAGKSRVDLLARVKLSHDKLKDLRERKASLEARTLEALSKNVNPSLINEVAEEIARLENLITAEEQVLSNLEVSRDGVEKAVAATAQRIAQFEQQMEVVKATEAMQRAQ-QAVTTSTVGASSSVSTAAESLKRLQTRQAERQARLDAAAQEKVADGRDLDEKLAEAGIGGSNKSSAQDVLARLQRQQGE................................. 232
67 -12.500[U] KOG0999 Microtubule-associated protein Bicaudal-D  ali follow..  14  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE-QYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQEFEGLKHEIKRLEEETEYLNSQLEDAERQLEEALETLKTEREQKNSLRKELSH................................. 263
68 -12.500[U] KOG1078 Vesicle coat complex COPI, gamma subunit  ali follow..  11  2...............AQPLVKKDDDHDDELEYSPFMGIEKGAVLQEARVFNDPQVDPRRQVITKLLYLLNESFTKVEATEVFFSVTKLFQSKD---GLRRMVYLIIKELSPSSDEVIIV----TSSLMKDMNSKIDMYRANAIRVLCRIIDGT---------LLTQIERYLKQAIVDKNPVVSSAALVSGLHLLKTNPE---------IVKRWSNEVQEGIQSRSALVQFHALALLHQIRQNDRLAVSKLVGS----AQCLLIQRPFYEFLESCLRHKAEMVILEAARAITELDGVTSR--------ELTPAITVLQLFLSSPRP--VLRFAAVRTLNKVAMTHPMAVTNCNID---------------MESLISDQNRSIATLAITTLLKTG--NESSVERLMKQITNFMSDIADEFKIVVVDAIRSLCVKFPLKYRSLMTFLSNILRGGFEYKRAIVDSTIIRDIPDAKESGLLHLCEFIEDCEFTYLSTQILHFL-----------GIEGPNTSDPSKYIRYIYNRVHLENATVR---AAAVSTLAKFGFMVES--LKPRITVLLKR........................................................................................................................................................................................................................................................................................................................................................................................................ 503
69 -12.400[YU] KOG4460 Nuclear pore complex, Nup88/rNup84 component  ali follow..  423..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLHKFLGSDEEDKDSLQELSTEQKCFVEHILCTRPLPCRQPAPIRGFWIVPDILGPTMICI---TSTYECLIWPLLSTVHPASPPLLCTREDVEVAESSLRVLAETPDSFEKHIRSILQRSVANPAFLKASEKDIAPPPEECLQLLSRATQVFREQYILKQDLAKEEIQRRVKLLCDQKKKQLEDLSYCREERKSLREMAERLADKYEEAKEKQEDIMNRMKKLLHSFHSELPVLSDSEKELQLIPDQLRHLGNAIKQVTMKKDYQQQKMEKVLSLPKPTAYQRKCIQSILKEEGEHIREMVKQINDIRNHVN........................... 740
70 -12.400[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  1MSSGEQPCYTLIHVPSDAELPSEAQLKEKFEKGGD-KERIEALKKLIYMILNGEKTSQSMLMYVIRFCLP--SNEHTLKKVLLIFWECVPKTDSNGKLLHEMILV------------------CDAYRKDLQHPNEFVRGSTLRFLCKL---REPELLEPL------MPAIRACLEHRHSYVRRNAVCAIFTIYKNFEF-----LIPDAPELVTEYLEQE---QDASCKRNAFMMLLHVDQARALD---------LSGCIDQVGSFGD-------------LQLVIVELIYKVCHNNPNEASR--------FIRCVYNLL--QSSSPAVRYEAAGTLVTLSNVPAAVKAAASA---------------YIDLIVKESDNNVKLIVLDRLVALRGSSSNEKIL------------------------------------LVMDILRVLSSPGLEVRKKTLSLALDLVSSRNVEDMVMFLKKEINKTANGKYRQELVKTLHAATIKFPDVASTIVPSSYVLQFVREAVHKLPNLKNAILGALREGI------------PFIQSPTIFMSALWILA--TYCEADGALDVLKLVKNSLGELPLVDSELSGQEEQKPEEQQPEQQQKQKPKVTADGTYATQTALSSTVTTSKKNEKPPLRRFLLDGEFFLGASLATVLTKLAQQFTELN---GAASERANRFRAECMLILSSIIHLAKSGLCIVHQQVNEDDLDRMGATIKILAQGIPGLDEQYGDDCKKSLELMLGAKSISRLDVTTEKMASTTAAGYRSKDFVEIDKTINFTQLSARSNQQGENLFDLSLSQALGTAPKAQKFDFSSSKLGKVIQLAGFSDPIY-AEAYVNVNQYDIVLDVLIVNQTSDTLQNVSLELATVGDKLVDKPTPVTLAPNDFSNIKATVKVASTENGVIFSTIS.................................. 813
71 -12.200[S] KOG3990 Uncharacterized conserved protein  ali follow..  13  150......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKKRPHEKTSSSHRDSAAAKKPSRNELGKSGSGANNSGVNAVSGAGLDLPDKISRGNGGNGTIAAPAAITVDTNSSDHVVAITYLKERIASLEKRLNQKDKELLEKDKQLTELKGKNFEKENDMRNRLKEVERLDMKVDNLNRKIASVLKELAVLKKSSNKKTAAISKAEKEIIKRENLSPKEEILATTGPEKPTKASSEPADLDKDEKSRDRDEERSEQGDRASVRSRSAS.... 382
72 -12.200[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAETLSGLGDSGAAGPAALSS------------ASSETGTRRLSDL------------RVIDLRAD-------RKRNVDSSGNKSVLME------------RLKKAIEDE-GGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKE. 397
73 -12.100[S] COG4717 Uncharacterized conserved protein  ali follow..  12  506.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SRNSRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWEAEMAPSFTQVERFMNEFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRRTFEERVSMLLPVNQQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLELEQEIQYFHAQIEQLFAAAAAKDRDIAAISRQLKDTENKLHHVNAQLQGGYPEELELADTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEAMVSDLKLQTEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRL... 838
74 -12.100[U] KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex  ali follow..  14  29........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RDLPDGPDAPADRQQYLRQEVLRRAEAAASTSRSLALMYESEKVGVASSEELARQRGVLERTEKMVDKMDQDLKISQKHINSIKSVFGGLVNYFKSKPVETPPEQNGTLTSQPNNRLKEAISTSKEQEAKYQASHPNLRKLDDTDPVPRGAGSAMSTDAYPKNPHLRAYHQKIDSNLDELSMGLGRLKDIALGMQTEIEEQDDILDRLTTKVDKLDVNIKSTERKVRQL..................................................... 258
75 -12.100[U] KOG0810 SNARE protein Syntaxin 1 and related proteins  ali follow..  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MRDRLPDLTACRKNDDGDTVVVVEKDHFMDDFFHQVEEIRNSIDKITQYVEEVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANKIAA---KLKAIEQSFDQDESGNRTSVDLRIRRTQHSVLSRKFVEAMAEYNEAQTLFRERSKGRIQRQLEITGRTTTDDELEEMLES-----------------------GKPSIFTSDIISDSQITRQALNEIESRHKDIMKLETSIRELHEMFMDMAMFVETQGEMINNIERNVMNATDYVEHAKEETKKAIKYQSKARR......... 262

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Slabinski L, Jaroszewski L, Rodrigues AP, Rychlewski L, Wilson IA, Lesley SA, Godzik A. The challenge of protein structure determination--lessons from structuralgenomics. Protein Sci. 2007 Nov;16(11):2472-82.