current user: public
If you have questions about the server, please let us know.

Query: [D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350
# Score Template Links and tools%idFirst MTTVTPSAGRELSNPPSDGISNLRFSNNSDHLLVSSWDKRVRLYDVSTNSLKGEFLHGGAVLDCCFHDDFSGFSVGADYKVRRIVFNVGKEDILGTHDKAVRCVEYFDFSILFFYTLCLFCDVTGQVITGSWDKTVKCWDPRGASGPERTQVGTYLQPERVYSMSLVGHRLVVATAGRHVNIYDLRNMSQPEQRRESSLKYQTRCVRCYPNGTGYALSSVEGRVAMEFFDLSEAAQAKKYAFKCHRKSEAGRDIVYPVNSIAFHPIYGTFATGGCDGFVNIWDGNNKKRLYQYSKYPTSISALSFSRDGQLLAVASSYTFEEGEKSQEPEAIFVRSVNEIEVKPKPKVYPNPAALast
1 -112.000[D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily  ali  100  1MTTVTPSAGRELSNPPSDGISNLRFSNNSDHLLVSSWDKRVRLYDVSTNSLKGEFLHGGAVLDCCFHDDFSGFSVGADYKVRRIVFNVGKEDILGTHDKAVRCVEYFDFSILFFYTLCLFCDVTGQVITGSWDKTVKCWDPRGASGPERTQVGTYLQPERVYSMSLVGHRLVVATAGRHVNIYDLRNMSQPEQRRESSLKYQTRCVRCYPNGTGYALSSVEGRVAMEFFDLSEAAQAKKYAFKCHRKSEAGRDIVYPVNSIAFHPIYGTFATGGCDGFVNIWDGNNKKRLYQYSKYPTSISALSFSRDGQLLAVASSYTFEEGEKSQEPEAIFVRSVNEIEVKPKPKVYPNPAA 354
2 -82.200[A] KOG0647 mRNA export protein (contains WD40 repeats)  ali follow..  35  24....DLANDIVINSPAEDSISDIAFSPQQDFMFASSWDGKVRIWDVQNGVPQGRAESSSPVLCTRWSNDGTKVASGGDNALKLYDIASGQTQQIGMHSAPIKVLRFVQ----------CGPSNTECIVTGSWDKTIKYWDMRQPQPVSTV-----MMPERVYSMDNKQSLLVVATAERHIAIINLANPTTIFKATTSPLKWQTRCVACYNEADGYAIGSVEGRCSIRYIDDGM-QKKSGFSFKCHRQGSNGQSLVYPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHRLKGYPTLQASIPVCSFNRNGSVFAYALSYDWHQGHMGNRPDVIRLHATTDEEVKEKKKR...... 365
3 -63.100[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  13  449..LRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSAHKGPVLCVVMSSNGEQCYSGGDGLIQGWNTTNPNIDPYDSYDPSV--LRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVDIKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTDTTANSSCQINRVISHPTLSISITAHEDRHIKFYDNNTG-------------KLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHEESIHDVAFHPSKCYIASAGADALAKVF.............................. 779
4 -61.100[ABO] KOG1446 Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2  ali follow..  16  5LIDVRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVSKKYGVDLIHFTHANNTAIHSSDDTIRYLSLHDNKLRYFPGHTKKVIS--------------LCISPVEDTFLSGSLDKTLRLWDLRSPNCQGLMHLSG----RPIAAYDPEGLIFAAGVNSESIKLYDLRSFDKVTFKLNQEKECDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPL----------QTFTGYPNNKGIPIEASFSPDSQFIFSGSTDGRVHIWNADTGNKVSVLNGHPGPVQCVQFNPKYMMLASACTNM-----------AFWLPTSEEG.............. 316
5 -60.900[S] KOG0293 WD40 repeat-containing protein  ali follow..  15  263.....PSQTAQILESHTDEVWFLQFSHNGKYLASSSKDQTAIIWEISADGHISLKGHHKPVIAILWSPDDRQVLTCGEEVIRRWDVDSGD-------------CVHMYEKGGISPISCGWYPDGQGIIAGMTDRSICMWDLDGREKECWK--GQRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREAT----VERLIEEEDMITSFSLSNDNKYILVNLLNQEIRLWNIEGDPKIV---------SRYKGHKRSRFIIRSCFGGYKQAFIASGSEDSQVYIWHRSTGKLIVELPGHAGAVNCVSWSPTNLHMLASASDD----------GTIRIWGLDRINQQNQKKVQGSSSN 580
6 -57.700[JT] KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)  ali follow..  14  5...........LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYGHTGAVWCVDADWDTKHVLTGSDNSCRLWDCETGKQLALLKTNSAVRTC--------------GFDFGGNIIMFSTDKQMVSFFDLRDPSQIDNMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVL--VNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTF--------------RTERPVNSAALSPNYDHVVLGGGQEAARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDG-----------YVRIHYFDPQYFEFEFEA...... 325
7 -57.400[S] KOG1407 WD40 repeat protein  ali follow..  14  10......SLHSREYQGHKKKVHSVAWNSNGTKLASGSVDQTARIWNIEPHGDLELKGHTDSVDQLCWDPKHSDLTASGDKSVRLWDARSGKCTQQVELSGEN--------------INITYKPDGTHVAVGNRDDELTILDVRKFKPLHRR---KFNYEVNEIAWNMPGDFFFLTTGLGTVEVLSYPSLKPL--DTLTAHTAGCYCIAIDPKGRYFAVGSADSLVSLWDISDM-------------LCLRTFTKLEWPVRTISFNYSGEYIASASEDLFIDIANVQTGRTVHQIPCR-AAMNSVEWNPKYNLLAYAGDDKNPKYNT--DEGVFRIFGFESS.............. 315
8 -57.400[A] KOG0265 U5 snRNP-specific protein-like factor and related proteins  ali follow..  18  41..TSNLQAPIMQLEGHEGEIFTAEFHPEGELLLSSGFDRQIYIWQVYEDCVMAMSGHSGAVMEAHFTPDGSHIFTCSDKTLAFWDIATGQQRRFKGHGNFVNSVQGSRRGQ-------------QLLCSGSDDRTIKIWDARKKHAAHTL---ESPFQVTAVCFGDTGEQVISGGIDNEVKIWDIRKQA--VLHHLRGHSDTITGMSLSPEGDFILTNAMDNTLRVWDVRPYAPGERCVKVFQGHQ-----HNFEKNLLRCAWSPGSDKITSGSADRHVYIWDVNTRRILYKLPGHNGSVNAVDFSPKEPLILSGSSDK-----------TLYLGEIDE............... 347
9 -57.200[R] KOG0289 mRNA splicing factor  ali follow..  14  208...RQVASHVGLHSASIPGILALDLCPDTNKILTGGADKNVVVFDKSSEQILATLGHTKKVTSVVFHPSQDLVFSASDATIRIWSVPNASVQVVRAHESAVTGL--------------SLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNV--ANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQ------------LDNNFEVKSLIFDQSGTYLALGGTDVQI--YICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDR-----------SLKFYSL................. 504
10 -56.900[S] KOG0310 Conserved WD40 repeat-containing protein  ali follow..  14  14....RKQETILLDEDEPAVVSSVRISPKKPYHVATTSSVRLTLYDTVVCEPLNLFRFKKGVCSIDFRHDGRLLAIGGEGKVRIFDVEKTTGSS--------KVALRVMQASQSTVKSVHFSPRGDTVFSMADDGKIKQYRVADTAYGVNIEIQAHEDAIRCGAVSSNDHIVLTGGYDHKVRLWDIRSKEKSLEL---DCEHPVESVLFLPGEQLIATAA-GPIVKIWDTTTG-------------RQLTALQAHYKTVTSLRLATNSTCLLSAGIDRRVNAFRTTNYSLINSW-SMPSPVLDIDVSRDDQTMAIGMGNL-----------LALYRRAEIKKEATASAAIEDKRS 333
11 -56.700[R] KOG1334 WD40 repeat protein  ali follow..  15  261RTFVQRFRLQYLLGSHAGSVSTIHFNQRGTRLASSGDDLRVIVWDWVRQKPVLNFGHDINVIQAKFFPNCGLAMCGHDGQVRVAELINASTKRVAKHRGPAHELALEPD-------------SPYKFLTSGEDAVVFTIDLRQDRPASKVVVNDKKVGLYTISMNPANIQFAVGGHDQFVRIYDQRRIDKPHHLVYCDFPTNITCVVYSHDGTELLASYNDEDIYLFNSSLSDGAQYV-------KRYKGHRNNDTIKCVNFYGPRSEFVVSGSDCGHVFFWEKSSSQIIQFMEGRGDIVNCLEPHPYLPVLATSGLD-----------QHVRIWT-PTAKTATELTGLKDVIK 607
12 -56.700[R] KOG0286 G-protein beta subunit  ali follow..  15  39VVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPRSSWVMTCAYAPSGNFVACGGDNMCSIYNLKSREGNV---------KVSRELSAHTGYLSCCRFLDDNN-IVTSSGDTTCALWDIETGQQKTVFV--GHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGT--CRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF-----------SHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN............................. 340
13 -56.400[S] KOG0296 Angio-associated migratory cell protein (contains WD40 repeats)  ali follow..  15  88IWDITTGEQICQLTGHKDSIVAIDWSFDGTYIATGGMDSQVRLWKSSTGFEFITAETVDEIVWLSWHPKGLFLAAGCDGSIWMWSLPSGKVQVMYGHTAPVNAGKFIPPG------------VGKRLATVDDSGTLIVWNPATGAPECRMSNEETAAGWTSFDCNAEGNVLFLGGSSGKVKVVNINSSH--ILASLEAQTESVEAIALCTALPICACASVDGTVALYDSASLKFRKSL--------------PHEQAVIDCKFLPNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDT-----------ELLVFDCEH............... 399
14 -56.200[R] KOG0645 WD40 repeat protein  ali follow..  13  1.............SGHTGRLWSVAAHPMLPLFATSSQDKSVRIYNSNTYNLVHVIFHTRSIRRVAWRPIERPVVASFDSVVSINEKIDDDWECTA-----------ALEGHENEVKCIAWSCNGNYLATCSRDKSVWIWEATEDDEFDCLVLQEHTQDVKVVTWHPTEDLLVSGSYDNSICFWRDDGDDWALTCQLQGHTNTVWALAFSPNGNTLASADNDGNVFLWIKISSNEDVATILQEEWKQQTSLPHIHKGAVYTISWMNDA-TLCSAGGDGKIVVYQREKHDEEQDHAHGVYEINSLEYLRDDR-LLSGGDDG-----------ECRVWSFK................ 322
15 -56.000[Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC  ali follow..  10  1.........MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKA-------------------------------------HELKEHNGHITGI--------------DWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFEAENDVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKKAMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHD------------CCPMLFIYDDRGCLTFVSKLDIPKQ 291
16 -55.700[S] KOG1409 Uncharacterized conserved protein, contains WD40 repeats and FYVE domains  ali follow..  13  18...GAKPALLHRITGHVARINDVILLSKDEGVWTASDDRSVRLYLKRDNDQFWPSFMPVAPTSLYYSEETYKLLVGLNGNVYEFSVADDESRKWTCHAGPISG--------------LGFALSSELIFSCSRDKSIVWHCSENSN-----KMGSYLLENSCTAMVIDLPFVFVGDHGGHVTVLRIVDNQPNLVSKLSAHTNAITSLTWDGNKKVLYSGSSDHLIIMWDIGGGRG------------EAYELNGHNGKVTTLCAAPAAKRLFSADEHGKLMCWDMNCKRPLAIPHEIHTGITAMHLQETLGLLVTSGQNR-----------VIMIWDVRSVCSAPS......... 412
17 -55.500[R] KOG0322 G-protein beta subunit-like protein GNB1L, contains WD repeats  ali follow..  13  1MAVLPPDPVFSLRSPDMGAVNSLCFQESDR-LLAGTIKGSVFLWDLQTNRSALHFEGSDPITSLHHTPDR-LVTQEKGGTITMFSIGGSSYVKERSIPGN------HLGFCRSALHTNTSKTNEQLLFYPCEESSIGVLHVTDAAAPTQILVPDDPQLPKKPFECASQLFLLAGYESGHFLTWDISSSV---ILDVMELAQDATSVDYDPVTNRGIVGGPTDKLISFSYQRSSMQMQLGSELCIKNP---------GVNGVRIRPDQKVFASAGWDGRIRIFSWKSLRPLAVLTQHNGGVMDLAFSSQAPIMAAAGMDG-----------QISLWDLYN............... 323
18 -54.600[S] KOG0316 Conserved WD40 repeat-containing protein  ali follow..  16  3ATEL-PTKEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYSHGREVRDVHVTSDNAKFCSCGDRQVYYWDVSTGRIRKFRGHDGEVNAV--------------KFNDSSSVVVSAGFDRSLRVWDCRSHSVEPVQI--IDTFLDTVMSVVLTKTEIIGGSVDGTVRTFDMRIG----REMSDNLGQPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVY-----------KGHISKSFKTDCCLTNSDAHVIGGSEDGLVFFWDLVDAKVLSKFRAHDL-VNSIDVDFYLRLLKFFVA---------GDKRELPPEGRLYVDFFGRWYNSCLEKM 317
19 -54.600[A] KOG0299 U3 snoRNP-associated protein (contains WD40 repeats)  ali follow..  11  125INPDVKIETAQLRGRHMRPLVGVVAYENF--VYSADKSGLIQKWEALQEKDTENRDHVKEITCLAISNDGRWIVTGGDHRIVIRDSVTLEQHCWKHHRDAVMG--------------LAMRRGTNEMFSCSADRSIKVWSLDQMSYIET--LFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIVEESQLVMKATAGYMEGSVDCVAMIDEDHFVTGSDNGVIALWSVQRKKPLFTYP-SAETSPDPVTIPPQPRWITSLAAIPYSNLFASGSWDGNIRLWKIAEGLRSFEPLSVYGCINSLSLSLQGKRVFAACGRE----------TRVGRWKTLRGI............. 499
20 -54.600[U] KOG1332 Vesicle coat complex COPII, subunit SEC13  ali follow..  15  7..........TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGIADLRGHEGPVWQVAWAHPMYLASCSYDRKVIIWREENGTSHEHAGHDSSVNSVCWAPHDY------------GLILACGSSDGAISLLTYTGEGQWEVKKNNAHTIGCNAVSWAPAVKRFASGGCDNLIKLWKEEEDGQKEEQKLEAHSDWVRDVAWAPSTSTIASCSQDGRVFIWTCDDASSNT---------WSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQISDVNKGQGSVSSVTEGQQNEQ........................................... 322
21 -54.300[S] KOG0282 mRNA splicing factor  ali follow..  17  277.....PKKQIHVWSGHTKGVSAVRLFPLGHLLLSCSMDCKIKLWEVYGERLRTFIGHSKAVRDICFNTAGTQFLSAADRYLKLWDTETGQCISRFTNRKVPYCVKFNPDED-----------KQNLFVAGMSDKKIVQWDIRSGEIVQEYD--RHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP-VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKK--------KIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPETSKVITCGWDG-----------LIKLWD.................. 579
22 -53.700[K] KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)  ali follow..  12  266LHEPNAEDAPSRDYIPLPPHKGVDILSEVEAVKDWSKRLHLGPRASLPSVCMYTFHTNNNMNCAEFSPDSTMIACGFESYIRLWSIKADKKSLPKSTSVEDSDGSVRLLSHSGPVYGTTFSPDNKYLLSCSEDASARLWSVDTKTALVAYK--GHTGPVWDVAFGPFGHYFATASHDQTAQLWSCDHIYPL--RVFAGHLSDVDCVTFHPNSAYVLTGSSDKTCRLWDVHRG-------------HSVRVFNGHTQPVTAVAIAPDGHTMASADSEGLIHLWDIGTGRRIKTMRGHRGNIYSLSFSRESTVLVSGGSDC-----------TVRAWDVFKTNYNNPVSSSLTGSV 593
23 -53.200[A] KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  12  39VYDLKNNKSRTLSLESRYNYTNIALSPDGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTGVQCICFSPNGAFFAVAVQNVVLIFCAPGEITGEYNP------VLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYNLSGHTDAIVACFFEANSLHLNTISRNGQLCLWECSLAPSDLEPRKEQRDVQLTAANYNTRTKVLVVAFSSGAFYLYELPDREIGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKKFLVSSSLDGTVRAFDGQDVFDIFLWSVKTGKLLEIISGHEGPVV 525
24 -53.100[S] KOG0271 Notchless-like WD40 repeat-containing protein  ali follow..  11  89FRVRPVTRCSASIPGHGEPVISAQFSPDGRGLASGSGDQTMRIWDIELELPLHTCSHKSWVLCIAWSPDATKIASACNGEICIWNAKTGEQKTLKRHKQWITSLAWQPMH---------KDPTCRLLASCGKDGNIFIWDTVQGTVVRCLS--GHTASVTCLRWGGEGL-IYSGSQDRTVKMWRADDGV--MCRNMTGHAHWINTLALNTDYALRTSCFEPSKRCIKPDTVEECQKVAQ-PKETKQSINRMTGHMQLVNQVVFSPDTRYIASASFDKSVKLWCGRTGKYLASLRGHVGPVYQVAWSADSRLLVSGSADS-----------TLKVFELKTKSLYYDLPGHGDEV. 447
25 -52.900[Z] KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats)  ali follow..  14  85YVEKCTAPQPEQCMFHDDWISSIKGAEEW--ILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLLSASMDQTILLWEWNVERNKV---------KALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMELSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVGSGS---LKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLV----------SLSLTSHTGWVTSVKWSPTHEQLISGSLDNIVKLWDTRSCKALYDLAAHEDKVLSVDWTDTGLLLSGG------------ADNKLYSYRYSPTT............. 418
26 -52.600[S] KOG4328 WD40 protein  ali follow..  9  199.LDLLTLEPQNVARVVPGRIFVVQFLPCENMVAAGDKLGNVGFWNLDCGNIYLFTPHSAPVSSIVFQQNSRVISSSYDGLIRLMDVEKSVFDLVYSTDEAIFSLSQRPN-------------DEQSLYFGQDYGVFNVWDLRAGKSVFHWE--LHERRINSIDFNPQNPVMATSSTDGTACLWDLRSMGAKKPKTLSNHSRAVHSAYFSPSGLSLATTSLDNYIGVLSGANFENTCMIY---------HNNTSRWISKFKAVWGWDDSYIYVGNLSKKIDVINPKLKRTVMELHNPRAIPCRIHCHPNVGTLAGSTAGG-----------QVYVWTTK................ 516
27 -52.400[R] KOG0646 WD40 repeat protein  ali follow..  10  17SWDLKTGTEQLQFKPCASPAHGLTAVGESSQLSARNTSGSIFYWSWTKPQAEVKSYPVEPIKALAANNEGTYLVGGGSGDIYLWEVATGKLKKWHGHYRSVTC--------------LVFSGDDSLLVSGSQDGSIRVWSLIRGNTLYEHNFNEHTMSVTDIVIDYGGCVIISSSEDRTCKVWSLSRGK---LLKNIIFPSVINALALDPGGCVFYAGARDSKIYIGAINATSEYG--------TQVLGSVSEKGKAITCLAYCADGNLLISGSEDGVVCVWDPKSLRHVRTLIHAKGSRKGPVNNQIVRKTIVANSNK-----------TQVSWKSRGALIPPPLEKYERPVE 352
28 -52.300[B] KOG0273 Beta-transducin family (WD-40 repeat) protein  ali follow..  13  169......PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTPSNKDVTSLDWNSDGTLLAMGSDGFARIWTENGNLASTLGQHKGPIFAL--------------KWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFP--FHSAPALDVDWQNNMT-FASCSTDMCIHVCRLGCDHPV--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA-------------CVHDLQAHSKEIYTIKWSPTGPMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDK-----------YVHIWNTQSGSLVHSYQGTGG... 495
29 -52.100[A] KOG1272 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  12  113EVDILSSRNQYDIVLPDFGPYKLDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQVRETVRDVAFLHNDQFFAAAQKKYAYIYGRDGTELHCLK---------------ERGPVARLRFLKNHFLLASVNMSGQLHYQDVTHGGMVASIR--TGKGRTDVMEVNPYNSVVGLGHSGGTVTMWKPTSQAPL--VQMQCHPGPVSSVAFHPNGHLMATSGKERKIKIWDLRKFEEVQTIGSSHNYTRYMNHSMVKGYQIEKVMFRPYEDVIGIGHSMGWSSILIPGSGEPNFDSWVA-NPFETSKQRREKEVHSLL---------DKLPPETIMLDPSKIGAMRPSRRKEKPSRG 469
30 -52.100[A] KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats)  ali follow..  11  50LERVFAKPFLASLDGHRDGVNCLAKHPEKATVLSGACDGEVRIWNLTQRNCIRTIAHEGFVRGICTRFCGTSFFTVGDKTVKQWKMDGPGEEPLHTILGKTVYTGIDHHWGFDSISSVKFNPIETLLGSCASDRNIVLYDMRQATPLKKV---ILDMRTNTICWNPMEAIFTAANEDYNLYTFDMRALDTPV-MVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYH------------TKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKKFQHYPHIKRIARHRHL------------PKSIYSQIQEQRIMKEARRRKEVN 420
31 -51.700[YU] KOG2445 Nuclear pore complex component (sc Seh1)  ali follow..  10  3..........PFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSDSWRAHDSSIVAIDWASPGRIIASASDKTVKLWEEDPDQEECSGRRWNKLCTL----NDSKGSLYSVKFAPAGLKLACLGNDGILRLYDALEPSDLRSIPPANHLQSDFCLSWCPSRPEKLAVSALEQAIIYQRGKDGKHVAAKLPGHKSLIRSISWAPSYQLIATGCKDGRIRIFKITEKLSPLA-------------SEESLTNSNMFDNSADVDMDAQGRSDSNTELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDG-----------KVRLWKATYSKCMSVITAQQ.... 349
32 -51.700[A] KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  13  178IMRGAPKKLVNTWKSHNSHITALLQVPDSRVVVALSRDQTMSIHETETQETLRVLPLYESIEGGAIGHNGNLFTVGEEGVVKEFVIETAKVRKKRIASSNLDHLAYDVVSHDEIYSCCLLGKDESHMAVASNTSEIRLYNTKTLDCQLIR--GHTESVLSVVSPTWDTSLLASCSKDNSIIFWRLVTSPENDSAAATGHANTVTALAISNTGRALASVSTDCTIKLWGLGVSDAEKDFVEQLPKLTCSSTMVAHGKDVNCVDISESDALIATGGMDKLVKLWQVDTHKMAGTLSGHRRGVGDVKFAKNSHKLASCSGDMTIKIWNADSAGIIKIWTIKTADCECSIDAHTDKI. 610
33 -51.600[S] KOG0295 WD40 repeat-containing protein  ali follow..  14  90ADWIPRPPETQKLTGHRLPITRVIFHPLWTIMASCSEDATIKVWDYETGQLERTLGHTDAVNDIAIDAAGKQLVSCSDLSIKLWDFGQTYDKSLKGHEHTVSSV--------------TFLPTGDFVLSASRDHTIKQWDISTGYCVYTFR--GHNDWVRMIRISNDGTLFASASLDQTVTVWSFATKS--AKLVLRDHEHAVECVEWAPDTAYLFSGSRDRSIKAWNINTGD-------------VLFTLLAHENWVRGLAFHPKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFHQTSPFVITGSVDM-----------SCKVWECR................ 404
34 -51.300[Z] KOG0318 WD40 repeat stress protein/actin interacting protein  ali follow..  8  48IRNIENPAIADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKEHLLKNPIAGPIKDISWSPDNQRIVAVGEGRGHVFMSETGTSVEISGQSKSINSADFRPARHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELVGEFGSPAHKGGVYALAWKPDSTQLLTCSGDKTCRLWTVESR-ELVSEFVMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPS------------KPLRVVKGHNKPITVLGLSDDRSTIYTGSHDGVVTNWNSGSGTND-RITGTGHGNQINGIAAWGDFVYTCGIDD-----------SLRQFSVEGNSYTDYVVKLNCQPR 412
35 -51.300[S] KOG0308 Conserved WD40 repeat-containing protein  ali follow..  11  15..KISFIIRDEHEYSNRSAVSALQYDAQNGRLFTGGSDTIIRTWSVPHHKDAFSAQHTDWVNDMILCGHGKILISASDTTVKVWNIERDNKDCIRTHKDYVSC--------------LAYAPIVEKAVSASFDHNIFVYDINANFKTVN-NLIGCKDSIYSLATTPNLSLVLGAGTEKCIRLFDPRTNEKI--MKLRGHTDNVRALVVNDDGTRALSAGSDATIRLWDIGQQ-------------RCIATCIAHEEGVWTLQVDSSFTTVYSAGKDKMVVKTPLYDFTKSQLLFKEEAPVKKLLLSEKDNPVSLWVG---------TWKSDIKRWSIRPSAQLSIGGDEDGPST 352
36 -51.300[T] KOG0279 G protein beta subunit-like protein  ali follow..  14  2...AEGLVLKGTMCAHTDMVTAIATPVDNDVIVTSSRDKSIILWKLTKEDQRRMTGHSHFVQDVVLSSDGQFALSGSDGELRLWDLATGESTR-------------RFVGHTKDVLSVAFSTDNRQIVSASRDRTIKLWNTLGECKYTISEADGHKEWVSCVRFSPNTLTIVSASWDKTVKVWNLQNCK--LRNTLAGHSGYLNTVAVSPDGSLCASGGKDGVILLWDLAEGKKLYSL--------------EAGSIIHSLCFSPNRYWLCAAT-ENSIRIWDLESKSVVEDLKTKVIYCTSLNWSADGNTLFSGYTDG-----------VIRVWGIGR............... 325
37 -51.200[R] KOG0315 G-protein beta subunit-like protein (contains WD40 repeats)  ali follow..  13  3.........................DQQQLILATGGYDHTIKVWQAHTGNCIKTMVETSQVNALDRTPDKTRLAACGYQCIRLYDLESNCTAPVI-----------NFDGVQKNVTRLGFQEDGNWMFTAGEDHHVRIWDMIAAPPHCS-RIFDCEAPVNAACLHPNQVEIAMGSQNGSVFLWDVKSER--HERIVPEVDASIQDVAISPDGRYLAAANNKGNCYIWSLTSQDQKMSTL------RPNRKIPAHSRYILRCKFSPDSRLLLTTSGDGTVCIWKTDDFSKWRELCIENYWVWDAAFSADSKWLFTASSDG-----------IARLWKLQTKSSIRDYTGHTKAIT 302
38 -51.100[S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat  ali follow..  11  107IIKLIPAACEAKISHGTQAISALRVEPPGVRFASGGLDYYVKLFDFQKMDMSMRYAESHVINSLAFSPNGETLVVASEAIIRLLDRAGKQWSETVRGDQYIIDLN-ITKGHTATVNCVEFNPLNKEFISCSDDGSLRLWNLDDHKVITKCGANGKRVSPQVCTFSPDGKWIAAGCDDGSVQAWKYGSQYNVNYLVRKAHNGSITSIAFSPDSKRLLSRGFDDTLKMWSLDNPKEPLL----------VKTGLENAFKSTDCGFSPRAEVVFTGDTPGTLQFFDPMTFDLVYKIDYPGISCHRIQWHPRLNQIIAGLSDG-----------TIHVYYDQTMSQRGVMSCVTKPLK 464
39 -51.000[A] KOG0640 mRNA cleavage stimulating factor complex; subunit 1  ali follow..  11  90LAPEPHSYETAYVTSHKQACRAGAFSCDGSLVATGSVDASIKILDVERMLAKSAPDHTDEVSYLEFHPKEHILASASDGTVKLFDIAKPSVKKA-----------HKVFTDCEPVLCLSFHPTGDYVAIGTEHNVLRVYDVATTQCFVSAPSQQHKAGVTCVKYSPTGKLYATGSYDGDIKIWDGISGRCINTIAEAHGGAAICSLEFTRNGKYLLSSGMDSLVYLWELCTSR-------PIQTYTGAGTTGKQEHQTEAVFNHTEDYVLFPDEATTSLCSWNSRNGCRLTLSLGHNGPVRYITHSPNGPAFLTCSDDF-----------RARFWYRRANN............. 423
40 -51.000[A] KOG0285 Pleiotropic regulator 1  ali follow..  11  4LNREVETQSLKKLSLKSVRRAREIFSPVHGQFPQPDPEGGVEPASKPTRDHNSEKTAPLKALALPGPKGSKELRKSAEKALVVGPTLPPRDLNNTGNPGKSTAILPAPGGHLGWVRSVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLT--GHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQNK--VIRSYHGHLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVL--------------PHDSDVFSVLARPTDPQVITGSHDSTIKFWDLRYGKSMATITNHKKTVRAMALHPKENDFVSASADNIKKFSTGGDKGGLWFWDWKSGHNFQRAETIVQPGS 422
41 -50.900[T] KOG4378 Nuclear protein COP1  ali follow..  14  1...................MMSNLVEPSWRLLAASG-GDTVKLFDVSADSGDPCVSPGCAVNSVKWNHTNLVVASTGDKKISLWRKNGQSLGTVPVTGKD------GGDSAEECLSAISFSKKGSRICSGGTGQIVKIWDLQRKLCIKKLK--GHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARATEGQVVQFVHVLRLLDYSRSSRHLVTAGDDGTVHLWDTTGRS------------PKMSWLKQHSAPTAGVCFSPSNEIIASVGMDKKLYTYDSGSRRSSSCI-AYEAPFSSLAFGDNGYILVAGTSNG-----------RVVFYDIRGKP............. 303
42 -50.900[T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  11  13FAQCFGDKGDVEDITEADIISAVEFDHTGDYLATGDKGGRVVLFERNHSDYLKSLEIEEKINKIRWCKRTNFLLSTNDKTIKLWKLYEKNLKVVAENNLAAYPRRVYANAHAYHINSISVNSDAETYISAD-DLRINLWNLSISDHIKPENMEELTEVITSAEFHPNCNHLMYSSSKGNIKLLDLRQSDQDSKSFFSEIISSISDVKFSQNGRYILSRD-YLTLKIWDVNMEKAPVKT--VLRSKLCDLYENDCIFDKFECTFSGDDKHVLSGSYSNNFGIYPTDSSLPGDRGQDYNKKILHASWHPFEDSVAIAATNN------------LFVFS.................. 461
43 -50.700[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  13  436.....PTVESMVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIETDEVVRCVAWCPNPKIIAVATGNRLLLVNPKVGDKVLVKKTDDLLAEAPSQDVTHFKPIRQVTWHGRGDYLATVMPEGANRSALIQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVAT-QHNIRIYDLVKQE--LVKKLLTNSKWISGMSIHPKGDNLLVSTYDKKMLWFDLDLST------------KPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIVSHGMVYNDLKKLQTHEFGVLDVNWHPVQPWVFSTGADS-----------TIRLYT.................. 784
44 -50.600[U] KOG0276 Vesicle coat complex COPI, beta` subunit  ali follow..  14  3....LRLEIKRKLAQRSERVKSVDLHPTEPWILASLYSGTLCIWNYQTQVMAKSFETELPVRSAKFVARKQWVVAGADMYIRVYNYNTMDVKVFEAHSDYIRCV--------------AVHPTLPYVLSSSDDMLIKLWDWEKGWACTQI-FEGHSHYVMQVTFNPKDNTFASASLDRTIKIWNLGSPD--PNFTLDAHQKGVNCVDYFTGGDKLITGSDDHTAKVWDYQTKS-------------CVQTLEGHTHNVSAVCFHPELPIIITGSEDGTVRIWHATTYRLENTLNYGLERVWAIGYIKSSRRVVIGYDEGTIMVKLGREIPVASM.................... 308
45 -50.400[A] KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  16  402...QPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAA-ADSIKIWNRSTLQCIRTM-TCEYALCSFFVPGDRQVVIGTTGKLQLYDLASGNLETIDAHDGALWS--------------MSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLK--FFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGD-------------CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDK-----------SLRLWERTREPL............ 709
46 -50.200[R] KOG1273 WD40 repeat protein  ali follow..  11  5IIDPLQGDFPEVIELEHGVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIDCSAAITSVSWSKYGHRLLVSADKSLTLWDVSTGEKIARTILQQTPLQARLNPSNPPFSPAAACFNKCGDLVYIGNSKGEILIVDYKSVRVLALVSA-SGAAPVKNIVFSRNGQYLLTNSHDRTIRIYENLLPAKNKMKTVGSTKMHWKAPCFSGDGEWVVGGSAEHKIYIWD--------------RAGHLVKILEGPKEALIDLAWHPVHPIIVSVSLAGLVYIWAKDYTENWSAFAPDFKELENEEYVEREDEFDLIPETEKVKVLDVNEDEEVDIDTVEKDAF............ 405
47 -50.100[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  15  468GPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVNRDNYIRSCKLLPDGCTLIVGGASTLSIWDLAAPTPRIKAE------------TSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQ--GHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGR---QLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD--------------KYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISVDDKYIVTGSGDK-----------KATVYEVI................ 769
48 -49.900[R] KOG1188 WD40 repeat protein  ali follow..  10  54IYDKERLNVLREFSGYPGLLNGVRFANSCDSVYSACTDGTVKCWDARVAREKPVQYPSNIFISFDINCNDHIICAGTDALLVFWDARMNSQNL----STTKDSLGAYSETHSDDVTQVRFHPSNNMVVSGSSDGLVNVFDINIDNEEDALTTCNSISSVSCIGWSGKGKQIYCMTHDEGFYWWDLNHLDREVVNMKEDALDYLIGGLYHEDTLHVIGGTNKGRIHLMNCSMSGLTHVTSLQ----------GGHAATVRSFCWNVQDDSLLTGGEDAQLLLWKPGAIEKTFTKKESMKIASSVHQRVRVHSNDSYKRR.................................... 384
49 -49.900[R] KOG4497 Uncharacterized conserved protein WDR8, contains WD repeats  ali follow..  9  33VRDVNTLQILQLY-TCLDQIQHIEWSADSLFILCAMYKGLVQVWSLEQPEWHCKIEGSAGLVASCWSPDGRHILNTTHLRITVWSLCTKSVSYIKYPKACLQGITFTRDGDTQDLTGIEWAPNGCVLAVWDTCLEYKIL-SLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSYDGKVRILNHVTWKMITETDRANPKMGIGMLAFSPDSYFLATRNDNIPNAVWVWDIQKLR------------LFAVLEQLSPVRAFQWDPQQPRLAICTGGSRLYLWSPAGCMSVQVPGEGDFAVLSLCWHLSGDSMALLSKDHFCLCFLETEA--------VVGTACRQLGGHT.... 460
50 -49.800[R] KOG2444 WD40 repeat protein  ali follow..  12  1...........MLVEFDNPPLCMKSNKDGSRLVVGFVDGSIRFYDTQQHEEEFQEQTKSSIRGVDLDEHKKRVYAVTNRSLCVFDIDTGKRCILKCHRSVPTAICTLPPT----------ALKSQQLATADESGEVKTWNLDPEVASENANIQEQDEDINDLKVDVKSNLLATSS-DGTLGAYDLRKA----KLKMRSELMHSELYSVCGTNRSVYVGGEDGYVEVFNLNEYGNLLERVES-----------GFEMGVNGIVELRSGLLGLTSQGSNRMRLLNVQPSKRLGYAGYHDDGIDAITISTDKSTVFTMISMS----------CTIKKWDMGP............... 308
51 -49.500[R] KOG2055 WD40 repeat protein  ali follow..  12  209........DANFQAPSHSGIRCMSIHPYFPLLLTCGFDRTLRIYQLDGKVVTSLHLRSSALQTALFHPDGKRVIAAGRKYMYIWDLESAQVQKVSR--------MYGQENFQPSMERFHVDPTGKYIALEGRSGHINLLHALTGQFATSF---KIEGVLSDVLFTSDGSEMLVLSYGAEVWHFNVEQ-RSVVRRWQVQDGVSTTHFCLDPSNKYLAIGSKSGIVNIYDLQTSNADAA-------PKPVTTLDNITFSINSMSFSQDSQVLAIASRKDTLRLVHVPSFSVFRNWPTPLGRVTCLAFGKGGE-LCVGNEAG-----------RVGLWKLAHYDLKFVPDKII.... 528
52 -49.400[R] KOG2096 WD40 repeat protein  ali follow..  11  79.........LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDASLRINLPAGGHPTAVAFADDASSIVVACHHMSGS-DQQGKLPLPSIKWDHHHIHEKRSVLTISGATATYGTADGSVVIASCSEGTDIVLWHGKTGRNLGHVD--TNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIVYQKDSRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWNINVRYHLDEDPKTLKVFPILCDSGGNPLHYDRLSLCPEGKILAASH-GSTLQWLCAETGNVLDTAKAHEGDITCISWAPKAMVLGTSGDDK-----------KVKLWEAPKSQS............ 453
53 -49.400[S] KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains  ali follow..  10  257VWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGEITSLLLDTRRKLPLIRSKKAKVVLCVTFSENGDTITGDSSGNILVWGKGTNRIAVQGAHEGGISPLCMLRDGHTDELWGLAIHASKPQFLTCGHDKHATLWDAVGHRPVWDK---IIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKD--LVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCS---------GHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVESDGTDINAVCRAHEKKLLSTGDDFG-----------KVHLFSYPCSQFRAPSGGHSSHVT 690
54 -49.200[U] KOG0277 Peroxisomal targeting signal type 2 receptor  ali follow..  13  2..SAVCGGAARMLRTPGRHGYAAEFSPLPGRLACATAQGTLLILDPDEAGLFRSFDWNDGLFDVTWSENNELITCSGDGSLQLWDTAKAAGQVYKEHAQEVYSVDWSQTR------------GEQLVVSGSWDQTVKLWDPTVGKSLCTFR--GHESIIYSTIWSPIPGCFASASGDQTLRIWDVKAAGVR--IVIPAHQAEILSCDWCKNENLLVTGAVDCSLRGWDLRNVR------------QPVFELLGHTYAIRRVKFSPHASVLASCSYDFTVRFWNFSKPDSLETVEHHTEFTCGLDFSLQSPTQVADCSWD----------ETIKIYDPACLTIPA.......... 323
55 -49.200[U] KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p  ali follow..  11  2...ASNQQPPSNLQTYGVPIYAVDWILEEAVRSKITKDQDDDDDDGSSSSSYIVLSGTDLPYRMAIHPRQGGLICALPNSCRLFDWENIIEDDNEEESEKVVKEL----KDVGQQLSLSFNQDGTVLATGAEDGTLRVFEWPSMKTL--LNESKTHASVKSLTFSESGKFLVSLG-APLCRVWDVNAS-AAIASLSKEKDEMFASCRFSVDNSGAANTQRGGSIITWDTTSWR------------RRSSKLIKRNNSISAFNVSADGKLLAVGTLEGDVLIIDSTKMQTNQIVKAHLGLVTALTFSPDSRCLVSVSFDS-----------RARLTVIKQKGEKRRV........ 356
56 -48.400[R] KOG1524 WD40 repeat-containing protein CHE-2  ali follow..  14  39LTNTATNESQQILNMPETFFRSQTKGGQNDVFAVSTSDGKINILSRNGKVENMVDAHNGAALCARWNSDGTGLLSSGDGFVKMWSRSGMLRSVLAQFATAVYCVAWDSTSHDGIILCCDWNPTSDLIVTGGEDLKFKVWDGFGQIL---FNSSVHDYPITSISWNTDGTLFAVGSHN-ILRLCDKSGWS---HSLEKMNAGSVMALSWSPDGTQLAVGTAAGLVFHAHIIDKRLTYEEFEIVQTQKTVPGQVMALLDERKIDLANDTLVVRDRADNKVLHFFDPTTGKAQGDGNKHEHDIVELTVNQCGRNVAFRDQIG-----------AVHIAMVKTFGVSQRMVKIGSLVE 508
57 -48.300[T] KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  9  16....QVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQEDYLKSLEIEEKINKIRWLPQKNFLLSTNDKTIKLWKISERDKRPEGYNLKEASPRRIFANAHTYHINSISINSDYETYLSAD-DLRINLWHLEITDRSFNINMEELTEVITAAEFHPNSNTFVYSSSKGTIRLCDMRASALCDRSFFSEIISSISDVKFSHSGRYMMTRD-YLSVKIWDLNMENRPVET--YLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASFNKKILHTAWHPKENIIAVATTNN------------LYIFQDKVN.............. 447
58 -48.200[R] KOG0288 WD40 repeat protein TipD  ali follow..  16  215VESTIPSTCANRIHAHEGGCGSIVFEYNSGTLFTGGQDRAVKMWDTNSGTLIKSLGSLGNILDMAVTHDNKSVIAATSNNLFVWDVSSGRRHTLTGHTDKVCAVDVSKFS-------------SRHVVSAAYDRTIKLWDLHKGYCTNTV---LFTSNCNAICLSIDGLTVFSGHMDGNLRLWDIQTGK--LLSEVAGHSSAVTSVSLSRNGNRILTSGRDNVHNVFDTRTLEICGTLR---------ASGNRLASNWSRSCISPDDDYVAAGSADGSVHVWSLSKGNIVSILKEQTSPILCCSWSGIGKPLASADKNG-----------YVCTWT.................. 515
59 -48.000[R] KOG1539 WD repeat protein  ali follow..  14  172LWNINTKKMLYQFKGWGSSVTSCVSSPALDVVAIGCADGKIHVHNIKLDEEIVTFASRGAVTALSFSTDGRPLSGGSFGVISIWNLNKKRLVIRDAHDSSIISLNFLANGHSAPPLCIRFYSNGRHILSAGQDRAFRLFSVIQEQQSRELSRNHLLLAILACAISACGNFAVVGTAGGWIERFNLQSGIDMSEKRRYAHDGEVIGVACDSTNTLMISAGYHGDLKVWDFKKRELKSQWDVG--------------CSLVKIVYHRVNGLLATVADDFVIRLYDVVTLKMVREFRGHTDRITDLCFSEDGKWVISSSMDG-----------SLRIWDVILAKQIDGVHVDVPITA 624
60 -47.900[Y] KOG4714 Nucleoporin  ali follow..  14  12................SEKVSQVRWLPESERFVTGSWDNFVRLWRLQSNQCMDKVRMEDDVTAMEFVDKDTLAVSCADGHLSVFNVHRAVEEDQMQRTSRSGRLH-CFQRSQEPAPCTDLSVYGTDIATAGEDGCVSIVSVENVRQVKRQI--EADSMALFSICYISQQELVTANRMGVIRMLDARVATEAMVASQDDKSNFVSSLAKHPMQQHLLCGSEEGSITVWDMRNLS------------YPASYLSAHKSPINEIGFHQDPSKLFTAAEGGEVWMWSENKVLGCYNKDGHSPWLSGDSFDVHGSRLVCGGDTE-----------AVYLVDNIV............... 358
61 -47.800[R] KOG4227 WD40 repeat protein  ali follow..  12  37RLRGCRNLYKKDLLGHFGCVNAIEFSNNGQWLVSGGDDRRVLLWHMEQAIIQLKGEHHSNIFCLAFNSGNTKVFSGGDEQVILHDVESSETLDVFAHEDAVYGLSVSPV-------------NDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPEPRLLATANSKEGVGLWDIRKPQSSLLRYGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNS---------CTMKSCCFAGDRDYILSGSDDFNLYMWRIPANGAFMVLKGHRSIVNQVRFNPHTYMICSSGVE-----------KIIKIWSPKQPGCTGDLDGRIEDDS 380
62 -46.900[S] KOG0283 WD40 repeat-containing protein  ali follow..  12  388YKELSALHMCQEIQAHEGAVWTIKFSQDAHYLASGGADRVIHVWEVQECELMSMNGSLTPIHPSLCDSSGNEITVVEKKKKGKGSSGRRHNHIPDYVHVPETVFSFSDKGHLDAILDLSWSKSQL-LLSSSMDKTVRLWDIETKT----LKLFAHNDYVTCIQFSPDENYFLSGSLDAKIRIWSIQDRH----VEWSDLHEMVTAACYTPDGQGALIGSHKGICRAYDTEDCK----LSQTNQIDVQSNKKSQAKRKITSFQFSPVNPEVLVTSADSRIRILDGSEVIHKFKGFRNTCSQLSASYSQDGKYIICASEDS-----------QVYLWKNDFHRTRSTLTTQSHE.. 726
63 -46.800[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  12  2...........SLCGHTSPVDSVAFNSEEVLVLAGASSGVIKLWDLEESKMVRAFGHRSNCSAVEFHPFGEFLASGSDTNLRVWDTRKKGIQTYKGHTRGISTI--------------EFSPDGRWVVSGGLDNVVKVWDLTAGKLLHEFK--CHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFE--LIGTTRPEATGVRAIAFHPDGQTLFCGLDDG-LKVYSWEPV-------------ICRDGVDMGWSTLGDF-CINEGKFIGCSYYRNSVGIWVSDISEGAVSEDKNECMVKRFSVLNDQSERMGSGPRGSVS--VAQNPGSLKATLPLESGKVATMVSEK.... 333
64 -46.600[S] KOG0321 WD40 repeat-containing protein L2DTL  ali follow..  15  117......SRPSECLMMLNQLPFCLGFANNESLLAVCTETGALELFDSRFYDIHGWLAHNNAIFSVNFSKDDSLLATSSDQTSKVFDLSTQQCITRLGRRGVD-------GYHSHSVKQVNFCNDSPNLVSCSRDGSIIFWDMRTHGITIDGENSGRDCSITSATWLPQSTVISSCSANSALKLWDLRTVATTPELTTSKRDFGVTNVCTSPDGERIYAASRDSIIYEYSSRHLNSGFCKTYK-------DPRLRISSFYVKLACSPDGATLACGGGTSGVVVFDTTRNSSAMLTGGHTKDVTAVDWSSEGQ-LASISDDG-----------SVRVWNSSLHGSAANLREKNFS.. 480
65 -46.500[A] KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)  ali follow..  16  245QKKLQSLAPLCSQVGDTRPVSSAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLGHASYVGGVALRPGVKMASGGHDGAVKLWGFNNEEIADITGHMP-------------HRVSKVAFHPSGRFLATACYDSSWRLWDLEQKTEVLHQE--GHAKPVHCLSYHSDGSVLVTGGLDAFGRVWDLRTGRCI--MFLEGHLGAVFGVDFSPNGFHIATGSQDNTCKIWDLRRR-------------QPVYTIPAHTNLISDVKYQQEGSFLVTCSYDSTTKIWSNKTWQPLKTLQGHDNKVISVDIAPNSQYIATTSFD-----------RTFKLWSPDS............... 553
66 -46.400[DO] KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits  ali follow..  11  67LAVVMNQNRTRILAFRNKPKSLLSTNHSDSPHQNPKPVKPRRYIPQNSERVLDALRDDFSLNLLDWGSANV-LAIALGDTVYLWDASSGSTSEL-----------VTIDEDKGPVTSINWTQDGLDLAVGLDNSEVQLWDCVSNRQVRTL---RGGHESRVGSLAWDNHILTTGGMDGKIVNNDVRIRSS-IVETYLGHTEEVCGLKWSESGNKQASGGNDNVVHIWDRSLASSKQTR-------QWLHRFEEHTAAVRALAWCPFQASLLATGGDGKIKFWNTHTGACLNSVETGSQ-VCSLLWSQSERELLSSHG---------FTQNQLTLWKYPSMSKMAELNGHTSRVL 392
67 -46.300[S] KOG2110 Uncharacterized conserved protein, contains WD40 repeats  ali follow..  9  25IYNCDPFGKCFHKIQGATSIVEMLFSTSLVALVEKDDGNNLKLINTKKSTTICELTFPTPLLAVKLNRKRLLAV--LEEQIYVYDISNMLLHTIETTSNVFAVCALSPNDSRDHEPRTEGESSSPNVSNSAVSGQVILWDVINCKQITKIE--AHKDSLACLAFNSDGTMLATASDNGRIRVFAIPSGQRLYQFRRGSLPAQIYSIAFHPDSSLLTVTSSTQTVHIFRLKEVYSNL-------------ERQGLLPSSPPPKESLLRRSSRSLIGTVGGYLPQSPERDFAYAHIPGDKVTSIAAFGPDNTIVNVATYDG-----------NLYSFRVNTGGECAMVNHFCVGLT 371
68 -46.300[BK] KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily  ali follow..  9  343IWRPEKKTGVGELSHCALGFYGGHWSPNSLSILAHGYGGAFHLWRNVSSSQKVPSGHFAAVTDVTWARTGEYLLSVSDQTTRVFSAWKNDEGNEAEDEHWHELARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVVRVFEAPLSFLKTPLERNGGGEGLDTFETVPEAAPAELKEPPIEDQLAFHTLWPES--HKLYGHGNELFSLCSDHKGNLVASSCKAQSASMAEI--------WLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTKLMAKVEAHKRIIWACSWNPFGHQFATSSRD-----------KTVKIWSVENDAQILVLPPFGSSVT 745
69 -46.200[R] KOG2394 WD40 protein DMR-N9  ali follow..  9  161DLNSQEKDPVKSIHFSNSNPMCHAFAKDGHDLLIGLNSGDVYTVSLRQQLQDSVNNRQDRCTSISWVPGGDFVVAHADGNLYNKDIRDPTQFSVDKAKYSKSNPVARWHICQGSINSIAFSNDGAHLATVGRDGYLRIFDFLTQKLVCGGK--SYYGALLCCSWSMDGKYILTGGEDDLVQVWSMEDRK--VVAWGEGHNSWVSGVAFDSNWSSFGSVGQDTQLLLWDLEMDEQPAPCKRDVPKLSPIIAHRVHTEPLSGLMFTQES--VVTACREGHIKIWTRPSESENSSEANPTTALLSTSFTKDNKASLSSKIISGSTFKQ............................. 556
70 -45.000[KL] KOG4283 Transcription-coupled repair protein CSA, contains WD40 domain  ali follow..  17  27ILSLQLSNRKDFVSPHRGSVNSLQVDLEGRYLLSGAADGSAAVFDVQRATDYEASGLIAKHKCIF----------------------TVDKQHENGHKYAISSAIWYPI-------------DTGLFITGSFDHYLKVWDTNTAQAVVDFKMPGKVYRTAMSSMAMSHTLIAAGTEDVQVRLCDIASG---------------------------------------------------------AFSHTLSGHRDGVMSVEWSTSSEVLYTGGCDGAIRFWDIRRAGCFRVLDQS---QTQLGFRPPILKRTAVGSKVCS................................. 254
71 -44.700[S] KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins  ali follow..  15  230IWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLHHNEAVLHLRFSNGL-MVTCSKDRSIAVWDMASATDRVLVGHRAAVNVV----------------DFDDKYIVSASGDRTIKVWSTSTCEFVRTLN--GHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGA--CLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPR----APASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR............................................... 508
72 -44.200[S] KOG0294 WD40 repeat-containing protein  ali follow..  13  29FTDSVKFELKQTFADSSYARSITSLAVQWPWVASGGTDGRIFVYDMRTRKQSQIISHAGRVNTLKFTPDLSLLLSGSDGHMIATRVGSWTKEY-----------DWQKAHAGQAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTNLATLDFQTGCLSWSKQGDHFTLSG-PLVLEIWGIENAHVMRR----EMPSKPICITWLDGNE-CLTGLDNGNIAWISLKDEDDTPPTFI-----------LAHEVRVKAIAYL--NEFLATVSIAGQIKVWKIDMETRKLEEIARDCRPTDLGLLDLRQFGNVRPVEQRTKVEEKPKAKV....................... 338
73 -44.100[A] KOG0284 Polyadenylation factor I complex, subunit PFS2  ali follow..  14  117VDCILTKFIRTAMNKVKCPVYSVCWSPEGKRLITGCQTGEFTLWNGTAFNFETILAHDSAIRALKWASNEQWLLSADGGYVKYWQPNMNNAHMFSAH-------------KDEAIRGLAFAPTDVKFATASDDGTARVWDFARYTEERVLR--GHGAEVRCIDWHPTKGLIATGSRDQPVKIWDPKSGS--CLATLQEHKSSVMAVEFNKNGNWLLTGGRDHLVKMYDIRMM-------------KEMRTYRAHKKEVISLAWHPIHELFVSGGGDGSIVYWMVDGEKEIGLLHAHDQAIWSMKWHPLGHILATGSNDNNTKFWARNRPGDTV--EDIFGLSNTNMIGHLDKER 444
74 -44.100[S] KOG0270 WD40 repeat-containing protein  ali follow..  9  270KKKKKKSKTGHITTHHTDAVLSMAHNKFRSVLASTSADHTVKLWDLNSGNAARSLHSNKNVSSSEWHMNGSILLTGGDSRVALTDVRISDESQ---------MSKYWSAMAGEEIETVTFASEN-IILCGTDSGNVYSFDIRNNENRKPVTLKAHDAGISTLCSNKPGMMSTGAMGEKTVKLWKFPLDDASMVLSRDFDVGNVLTSSFAPDIEVMVIGGVNKVLKLWDVFTNR------------SVRKSFKSELENVQARAKEEAQKIGKSSRIARKYTSNDNPDTVITIDDQGEDEEEREGGDEHDDM............................................ 575
75 -43.900[E] KOG0280 Uncharacterized conserved protein  ali follow..  10  2...SETGIIPKSTDYTDWPADVCKYSQVFEDVLVV---GTYMLDESTKLR-HGKLVLYDTKEDVLSPHDASVLAVASTGHVSFYRHQFRAELMFLR--------GIKVADSSVLMLSLDFSDSGKELAVSMSNGSVLIIDIDSGVIKNKWK--EHDYEAWTCHYSRDNNLLYSGGDDAALVCYDQRIPNSIWRDIQVHHSGVVSILSRAPFGPYIATGEYGDFMHTLDT-------------RNIGKPLFSANLGGGVWRLEHMETTEKVLGILMHRGAQVLRISNDFSKRIFKEHESMCYGGDWRHTDGLLATCSFYD----------KRVCLWED................. 309
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 8 7 7   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24