current user: public
If you have questions about the server, please let us know.

Query: [S] KOG1043 Ca2+-binding transmembrane protein LETM1/MRS7, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580    .  590    .  600    .  610    .  620    .  630    .  640    .  650    .  660    .  670    .  680    .  690    .  700    .  710    .  720    .  730    .  740    .  750    .  760    .  770    .  780
# Score Template Links and tools%idFirst MSLRYASNAYHIGRYAQRLFATGQRNRVFHQYIASTSLQTTSLRYASTDRSKVEYTLKMLREDVQKQDEEAQKVLSLMKSDKDVATVKPPLKDRIIHELKHYYHGFRLLALETRVSAKYLWTVLRGATLSRRERQQLVRTVSDLFRLVPFSFFIIVPFMELALPIFIKLFPGMLPSTFQESSKEEEKWRKQVKLRVEMAKFLQDTIEEIGLERKTRNKESTRSLEFALFIKKVRNEGGYVSNEELLKFSKLFEDEITLDNLSMGQLRSLCRLMSINSLGSPEILRFQLNMKIRELKADDKQIAAEGGVDALSSIDLQSACRARGMRAIGVSEERLKEQLVQWLELSLNDKVPPALLLLSRTLYLPEEVSFPDRLKAIVQNLPDGLAETTKQKLTEMEGGQIDHKARIELIRSIESAIANEKKDEEKKKKAAEEALKSKEEAEKAKVQEKEKLVDVAAQAIVHELKKDIYDAVASTSSTTEAKEPAAKPSEAKEEKKEDITVDKKDLSHIEEIIVGGPIKEAKHDILGLREKVLEHKEDLMEINSLDGAFAETKIAKRLRHKLNSMIEDVDSMVDKLEDEKRNIREMLIDPTVENSVDLKKEREVRIQDVIDSLAKLKESKGEQADDGEQRERIEALLKTIDEDSDGIVDKQLVLEVIELLEKHTDVHVSAAQMASMIGTLKKEDEVAGLTEEIRKVQSGNYQMPILPTGPSSADAFNQPQGVYTASKQVPARSEQEGVEQKQQVENGPVGIPDVDTKVTSTLQQNSSKTSSSSTTKSTSDSKSALast
1 -164.000[S] KOG1043 Ca2+-binding transmembrane protein LETM1/MRS7  ali  100  1MSLRYASNAYHIGRYAQRLFATGQRNRVFHQYIASTSLQTTSLRYASTDRSKVEYTLKMLREDVQKQDEEAQKVLSLMKSDKDVATVKPPLKDRIIHELKHYYHGFRLLALETRVSAKYLWTVLRGATLSRRERQQLVRTVSDLFRLVPFSFFIIVPFMELALPIFIKLFPGMLPSTFQESSKEEEKWRKQVKLRVEMAKFLQDTIEEIGLERKTRNKESTRSLEFALFIKKVRNEGGYVSNEELLKFSKLFEDEITLDNLSMGQLRSLCRLMSINSLGSPEILRFQLNMKIRELKADDKQIAAEGGVDALSSIDLQSACRARGMRAIGVSEERLKEQLVQWLELSLNDKVPPALLLLSRTLYLPEEVSFPDRLKAIVQNLPDGLAETTKQKLTEMEGGQIDHKARIELIRSIESAIANEKKDEEKKKKAAEEALKSKEEAEKAKVQEKEKLVDVAAQAIVHELKKDIYDAVASTSSTTEAKEPAAKPSEAKEEKKEDITVDKKDLSHIEEIIVGGPIKEAKHDILGLREKVLEHKEDLMEINSLDGAFAETKIAKRLRHKLNSMIEDVDSMVDKLEDEKRNIREMLIDPTVENSVDLKKEREVRIQDVIDSLAKLKESKGEQADDGEQRERIEALLKTIDEDSDGIVDKQLVLEVIELLEKHTDVHVSAAQMASMIGTLKKEDEVAGLTEEIRKVQSGNYQMPILPTGPSSADAFNQPQGVYTASKQVPARSEQEGVEQKQQVENGPVGIPDVDTKVTSTLQQNSSKTSSSSTTKSTSDSKSA 784
2 -71.600[T] KOG4263 Putative receptor CCR1  ali follow..  16  87.............................KVRPSSSSSTQPTPSKKPEDEKRKELDTVKSKRDQMRDNMQDYIFTRYFNYVKNYDKVLEKNFPKAMQLYRVFFDGVKDFFGDMKRFLKIARIANDSRALNRQELELYMQMPRDMMKVAPALIGCSLPMVGAFFPLVFYYPRSFLTAHFWTPQQRSEFQSYYMKRRLCNNKDVFRCLQDKLKATASHP-----KHSAFADILGQLGSGTHPTPEMLIDVKDIFAEGYSLLGMSRKHVRNLVN---LHGLPSSIFKRHRLHEHAFLVHYMDQAITREGGVHNLTPDALRYSCYLRGLNPDSLSSEAMIEWLRKWVKVSTSIQGEHITLFLHLPILLGYNHPNNWKT--IYGKCPT................................................................................................................................................................................................................................................................................................................................................................................................................. 436
3 -12.900[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  8  557....................................................................................................................................................................................................................................................................................................................ESYMKEKLKQLIEKRGKENFIEKLGFISKH-HEFTKLVKELEGV-----ITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGA-----QMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQE-LLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIK-EERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKE------QDDLLVLLA--DQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDH............................................................................. 961
4 -12.400[R] KOG2295 C2H2 Zn-finger protein  ali follow..  9  275..................................................................................................................................................................................................................................................................................................................................................................................DEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQITRSEIEAVCNRFSGYLRVAIADPLVERRIKEICWGLNNQR-NRDLSRRVRPANGITAHKQVVRSDIKLCAKIALNLDEKFRLWAEGPKDDSNSARANESSENGSGSTYGFNSQNPVLQNITDYLIEEASAEEEELLGLTGENKDTEGEPIERDEQ......................... 704
5 -12.300[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  10  31...................................................................................................................................................................................................................................................................................................................LSDLRVIDLRADVRKRNVDSSGN-KSVLMERLKKAIE---DEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDI-EMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRTRATDLKNLFSKYGKVVGAKVTAEEATKCINHLHKTE-LHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSK 570
6 -11.700[T] KOG0027 Calmodulin and related proteins (EF-Hand superfamily)  ali follow..  9  2..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RSAKVGVARQLETKKPQTGRKISTSSRGTIHSQQSQPEDIQMKYTRKELKEYRQLFNMFDTELKQAMISIGLHANKAEIDNVIKEVDADGNGEIDFEEFCACMKKSQNI-----VKSTNEELIRECFEIFDQDRNGIITENEFKYIAKEFG-----DFDDELAEKVFRELDVS..................................................................................................... 173
7 -11.100[TU] KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily)  ali follow..  10  29..............................................................................................................................................................................................................................................................................................................................................................................................................................................AKPTVRKERVVRPDSELGERPPEDNQSFQYDHEAFLGKEDSKTFDQLTPDESKERLGKIVDRIDNDGDGFVTTEELKTWIKRVQKRYIFDNVAKVWKDYDRDKDDKISWEENPAEFHDSSDHHTFKKMLPRDERRFKAADEFTAFLHPEEFEHMKEIVVLETLEDIDKNGDGFVDQDEY---IADMFSHEENGPEPDWVLSEREQFNEFRDLNKDGKLDKDEIRHLVYESDKNKDEKLTKEEILENWNMFVGSQATNYGEDLTKNHDE...................................................................................... 330
8 -11.000[T] KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein  ali follow..  9  60.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QHADLERLARESQFSVNEVEALYELFKKLSCSIIDDGLIHKEE---------LRLALFQAPYGENLFLDRVFDLFDE---EFEEFIHALSVFHPYASIQEKTDFAFRLYDLRQTGFIEREEVQQMVSAILLESDMMLSDELLTMIIDKTFADADSDKDGKISKDEWNVYVH.............................................................................................................................. 224
9 -10.900[R] KOG4264 Nucleo-cytoplasmic protein MLN51  ali follow..  8  2..................................................................................................................................................................................................................................................................................................................................................................................................................................ADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTK-----------------STVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRK-QTQEEEVRPKGRQRKLWKDEGREHD------------------REDEQAPKSRQELIALIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEIS 348
10 -10.600[ZD] KOG0028 Ca2+-binding protein (centrin/caltractin), EF-Hand superfamily protein  ali follow..  13  67.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSGPKFELSEAQKCDIKEAFDLFDNEGTGYIEVKELKVAIRA--GFEPKKEEIKRMISDIDVFLQLMTIKMAEKDTKEEILKAFRLFDDDDTGKISFRNLKRVARELGETLTD--------EELREMIDEADLDNDGEVNQEEFLRIMK.............................................................................................................................. 216
11 -10.500[R] KOG0038 Ca2+-binding kinase interacting protein (KIP) (EF-Hand protein superfamily)  ali follow..  11  9.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEQELDDYQVSDQSDEVHFHTANFSSCIAGPQIGKDCTFFTRKEILRVHKRFRELRPDLVPRQMTEGQASSVPELREAFSRDGQGNLSFEDFLDALSVFSE-------QAPRDIKVFYAFKIYDFDQDGFIGHADLMSCLTTMTKN---ELSPEEHQQIADKVIEEADVDGDGK............................................................................................. 182
12 -10.400[S] KOG4358 Uncharacterized conserved protein  ali follow..  10  316...................................................................................................................................................................................................................................................................................................PKVLNSNPPPIIK-----YLALQDLMLLSQ---------YSPSRRQEVHNWTAISRE-----LNLLNGMTQKLILYQEAAATNGRVSSSYPVEPKKLNSPEETAFQTPKSSQMPRPSVPPLVKTSLFSSKLSTPDVVSPFGTPFGSSVMNRMAGIFDVNTCYGSPQSPQLIRRGPRLWTSASDQQMTEFSNPSPSTSISAEGKTMRQPSVIYSWIQNKREQIKNFLSKRVLIM------------------------------SKHPEASIQAVFSDAQMHIWALEGLSHLVAASFTEDR---VVQTTLPAILNLLTLQEAVDKYFKLPSGSLVDTSYKTLRFAFRASLK---------TAIYRITTTFGEHNAVQASAEHQKRLQQFLEFKE.................................................................................................... 674
13 -9.940[U] KOG4809 Rab6 GTPase-interacting protein involved in endosome-to-TGN transport  ali follow..  9  154...............................................................................................................................................................................................................................................................................................LQTQLKEVLRENDLLRKD---SKLSSSELKK---ERALR---KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSD--SKQHIEVLKESLTAKEQRAAILQTVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQ-EIHDLKDMLKVNVLQKKIENLQEQLRDK-QMSSLKERVKSLQADTTNTDTTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 673
14 -9.870[P] KOG1603 Copper chaperone  ali follow..  11  4.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DEMKSETKKTEHKQKQSTQIKQDLPPPTIPPLPLPYKSCTLKVS------------KRKVKKILTSIE-DVKGIISPEILLKKLNKAGKN----------AEQLPEIPDPVDNKPKPVDPKEKNKKKKKEEKVQITNEATSSGIDNPEKPGSGECDKPESEKPVDEKCLSGDGGETSGPVKEEKKDVLKEKDSGKEESPSPPADSSAPAAE 211
15 -9.820[Z] KOG0030 Myosin essential light chain, EF-Hand protein superfamily  ali follow..  11  5..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEDQTADLIPSTEFKEAFQLFDRTGD-YSQCGDVMRALGQNPTN--AEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKN-----KDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGE----KMTEEEVEMLVAGHEDSN.................................................................................................... 142
16 -9.740[Z] KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily  ali follow..  12  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAPKRAKRRTVAEGGSSSVFSMFDQTQIQEFKEAFTVIDQ-DGIIDK-----EDLRDTFAAMGRLNVKNEELDAMMKEASGPINFTVFLTMF-------GEKLKGADPEDVITGAFKVLDPEGKGTIKKKFLEELLTTQCD----RFSQEEIKNMWAAFPPDV.................................................................................................... 148
17 -9.340[S] COG2268 Uncharacterized protein conserved in bacteria  ali follow..  10  105......................................................................................................................................................................................................................................................................................................VKPSVEGIATAA--RTLSPEDLRMLVEDRAT-AAQMTMHELRENFVQGVQNTVAEDLSKNGLELES-VSLTNFNQTSKEHFNPNNAFDAEGLTKLTQETERRRRERNEVEQDVEVAVREKNRDALERKLEIEQQEAFMTLEQEQQVKTRTAEQNAKIAAFEAERHREAEQTRILAERQIQETEIEREQAVRSRKVEAEREVRIKEIEQQQVTEIANQTKSIAIAAKSEQQSQAEARANDALADAVRAQQNVETTRQTAEADRAKQVALIAAAQDAETKAVELTVRAKAEKEAAELQAAAIIELAEATRKKGLAE-AEAQRALNDAINVLSDEQTSLKFKLALLQSLPA-------IEKSVEPMKSIDG.......................................................................................................................... 475
18 -9.310[D] KOG4259 Putative nucleic acid-binding protein Hcc-1/proliferation associated cytokine-inducible protein, contains SAP domain  ali follow..  10  1......................................................................................................................................................................................................................................................................................................MPESD--------VTKMKVADLKRELKLRGLAVNG-NKTELQDRLQTALLEGDLSLEDS-----------------AIADAIDDDDVSFTDEDEHKLLGDENDDELLKSPVSTPTTVAIPDLLAEEKTSSAPDAAAPTKKIVLKRNNSQQSTGTVASTGTTPSKENEAPAAAASDSTGETPTKKHKPIVVGPKTEGEKPSGDKKLNQLTAQERLELRAKKFGITPPAVANTATAVAVAINKSSSASITANKGNKETEEQQKEALKKRAERFGFVVPDKAPTSKADDR---------------LQKRKERFGAGAVSAATTTPTTTESKDAWSEKARARLERF--KTAPSTN........................................................................................................................................... 308
19 -9.230[C] KOG0042 Glycerol-3-phosphate dehydrogenase  ali follow..  10  91.......................................................................................................RGLKTALVERD-TSSRSTKLIHGGKLDIEQYRMVKEALHERANLLEIA------------PHLSAPLPIMLP-----------VYKWWQLPYYWVGIKLYDLVAGSNCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPQTGKVHVS-----ARCKDKCVINATGVRKMDDKDAAAICQSAGVHIV-ATSDGRVIFFLPWQKMTISEEDINFILNEVRNYLSCDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISESGLITIAGGKWTTYRSMAEDTINAAVKTHNLKAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAATYGDKAFEVAKMASVTGKRWPIVGVHLVSEFPYIEA--------EVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWDDYKKQEQLETARKFLYYKKRFHKFDADQKGFITIVDVQRVLESINVQMDE--------NTLHEILNEVDLNKNGQVELNEFLQLMSAI---QKGRVSGSRLAILMKTAEENLDRRVPIPVDRS......................................................................................... 723
20 -9.140[K] KOG2578 Transcription factor E2F/dimerization partner (TDP)-like proteins  ali follow..  6  1...........................................................................................................................................................................................................................................................................................................................................................................................................................MEVNCLTLKDLISPRQPRLDFAVEDGENAQKENIFVDRSRMAPKTPIKNEPIDLSKQKKFTPERNPITPVKFVDRQQAEPWTPTANLKMLISAASPDIRDREKKKGLFRPIENKDDAFTDSLQLDVVGDSAVDEFEKQRPSRKQKSLGLLCQKFLASLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGRHSLPKTLRNLQRLGEEQKYEEQMAY--QKFVMLFLVSKTKIVTLDVAAKILQDAPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSSDEELVDVSASVLPELKRETYGQIQVCAKQKLARHGSFNTVQASERIQRKVNSEPSSPYREEQGSGGYSLEIG 446
21 -9.080[T] KOG0044 Ca2+ sensor (EF-Hand superfamily)  ali follow..  9  3.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KQNSKLRPEVLQDLRENTEFTDHELQEWYKGFLKDCPTGHLTRTFDTNGDGTIDFREFIIALSVTSR--------GKLEQKLKWAFSMYDLDGNGYISRSEMLEIVQAISSVMKMPEDESTPEKRTDKIFRQMDTNNDGK............................................................................................. 163
22 -9.040[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  12  1............................................................................................................................................................................................................................................................................................................................................................................................MTKKLALKRRGKDSEPTNEVVASSEASENEEEEEDLLQAVKDPGEDSTDDEGIDQEYHSDSSEELQFESDEEGNYLGRKQSSSAEEDEESSDEEDNEEEESTDGEEVEDEEKDSKSKQTDDKPSGSGAASKKALTAELPKRDSSKPEYQDSDTSDEEDIRNT-DEYKHIGYDWDAKKIIKPPQG--DQIDEFLRKIEDPDF-----------RTVKDPLTGQDVRLTD-IALIKRIVSGRIPNKDHEEYEPWIE----------TSEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREKQAKRG.................................................................................... 309
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 4 1   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.