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Query: [O] KOG1100 Predicted E3 ubiquitin ligase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAVEAHHLNPLFSSNREMIHPVEASGVVYNTQMRYGTVPTFNPTVECQTSLFNPIYNISPVDRLVHQSMKPTIQSVDSSLTFNSDNNVDFLRPVSSRKRSREESVVLNPSAYMQIQKNPTDPLMFLGQDLSSNVQQHHFDIDRLISNHVERMRMEIEEKRKTQGRRIVEAVEQGLMKTLRAKDDEINHIGKLNLFLEEKVKSLCVENQIWRDVAQSNEATVNALRSNLQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKGEASVLLLPCRHMCLCSVCGSSLNTCPICKSPKTASLHVNLSSLast
1 -92.100[O] KOG1100 Predicted E3 ubiquitin ligase  ali  100  1MAVEAHHLNPLFSSNREMIHPVEASGVVYNTQMRYGTVPTFNPTVECQTSLFNPIYNISPVDRLVHQSMKPTIQSVDSSLTFNSDNNVDFLRPVSSRKRSREESVVLNPSAYMQIQKNPTDPLMFLGQDLSSNVQQHHFDIDRLISNHVERMRMEIEEKRKTQGRRIVEAVEQGLMKTLRAKDDEINHIGKLNLFLEEKVKSLCVENQIWRDVAQSNEATVNALRSNLQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKGEASVLLLPCRHMCLCSVCGSSLNTCPICKSPKTASLHVNLSS 335
2 -36.000[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  14  26.............................................................................................................HYKRTAKVLKAAPQYNIDGDLKSVVERQRDKIRGTVTPIGVPLRSGVLQIVKLHEHRVTRGFAGFWTEQHKLLHESANEMPFELRNQSHGVEDVDVVYDNYEPSNLSLFDHVFGFFSGVRQRGLQTTEEVLREGSFLTAIGELELDGEEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKEIILLPCGHVCLCEDCAQKISTCPVCRGSIVSKAAAFIA. 338
3 -35.200[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  19  623................................................................................................................................................................................................................................................................EKQELLDRVSRLWKTMRECPAVEKLATDELCKICMDAPIECVFLECGHMATCTSCGKVLNECPICRQYIVRVVRFFRA. 700
4 -33.500[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  28  257.........................................................................................................................................................................................................................................................................ENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLNNCPICRLFPGPPADPGGAE 330
5 -32.000[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  12  217.RVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMK-GQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSKILTTGENYKTVNDIVSALLNAEKREEEKEKQAEEMASDDFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS. 618
6 -28.100[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  12  667...............................................................................................................................EDMQTQNQHLLQQVDYNIKLVSESVKTKHAYNTHLSEKQVMEKQLHQVNASVENFKARIAHNEEQMKGCFSEAYKLIQEDRHLVISLETTKWEVADADKQISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRLQEEVKNCKNILKCGVCFDRPKEVVIVKCYHL-FCQQCEIRHRKCPGCGTAFGQNRLVKM.. 899
7 -21.800[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  13  1..........................................................................................................................................MDLD--LNQE--------------------SSDSESPGGLMTALSPMLEELESAQERIQERIRQLEVIVSRIREREITTTTTPALVSPN------------EHRDSTAGVIHERSRERLVENGENKTYLIAKALNMEKTSSVPGGFFDCNICLEKAEDPILTCCGHL-FCWGCYLNIKECPVCDGEVTDAIPIY... 169
8 -20.200[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  15  223...................................................................................................................................................................................................................................................NDSLTILPRRSAENDPVVDLDVASPPKRVNRDIDESQKEELYKCPICMDSKREPVSTKCGHV-FCREC-RATHKCPICNKKLRQFFRIYL.. 319
9 -19.800[O] KOG4172 Predicted E3 ubiquitin ligase  ali follow..  30  1...................................................................................................................................................................................................................................................................................NGAQEVNEGDECTICMDAPVNSVLYTCGHMCMCFECGRRLGTCPICRAPVQDVIKTYKS. 63
10 -19.700[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  7  29LGLSAETISKLMAPTTVDPQQAITLSYSLGKEGHIVVPKIIINVNFDKLKTDKFAASMFKQLNASNMITTVRSNYASNVPSTPSDSTQQPPTNTLPSVSASSQSVETCETVDEDIDTQTMSSDMSEVQSMEISLN-CDHEFFEKLTSELQSV-EGLQREQRKILFNAIDILSHEISLIASPN----SKKKYKSLYCWRKIFEIYMDSDIFISCKEADQSHERTPELAERHLIMKKFDKRTSLTAQPLFFQVIESDPLLLVDNASKAICFSLSSKLFSIIPQLRDFECAICSNVAYKPVRLGCSHV-FCLHCKQKVDFCPLCRAKEVMNIDHALMN 417
11 -19.200[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  10  1...........................MEQKNLNINQASGSKINTELAVPIFQSRRRHRPRQGLKRKKGFKRDDDSGGSSESSNEDMRDNIPIVSGRKKTVRLNRLQRESEQFENSAL----------------KDINVEYQSNLSATGESVNTTTVSAINEDTREVILGRPSPKLANQSTLPTELFQSQNDYSRFLPKRKDFEKKSQVGPVLSSNASTVRMNTIIDYQPDVCKDYKLTGYCGREDYKAGWQLDREWDSVQEKYKKGAKLEEGMVKNEKKEDIPFVCLICKKDYRSPIATTCGHH-FCEQC-RKTPTCIQCGADTKGLFSV.... 301
12 -19.000[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  11  277............................................................................................................TDESRPNSDLLLNRICQLISQVLSRVTVPPGCFQFVVDMCSADLNAVTHYPIVTAALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFRGNFDPSSRPHIDPLTNDVRVPLPNNSKRIRADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKQTLLSDITLPSEDSLCPICCAKPITAVFTPCKHQS-CSDCIMQHKVCFYCKTTIQTIETLDGTV 522
13 -18.900[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  10  84...........................................................................................................................RTLGEEYVDLTYTNRKGCPYFITKLYKKIMKNNKESKIEDTESVAAFCKG-LLDFILDVHMTLFYFKGAFYSISKRIFGMRYVFKHILSKNEANFREEGLTSTLGSWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMSDPSCAPCGHL-FCWSC-KERPECPLCRQHCQPQEILVLRQ 337
14 -18.700[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  22  20......................................................................................................................................................................................................................................................................................YQLDTLLRCHICKDFLKVPVLTPCGH--FCSLC-NNQPNCPLCLFEVSEIIQSYTSL 90
15 -18.700[L] KOG0287 Postreplication repair protein RAD18  ali follow..  22  20......................................................................................................................................................................................................................................................................................YQLDTLLRCHICKDFLKVPVLTPCGH--FCSLC-NNQPNCPLCLFEVSEIIQSYTSL 90
16 -18.500[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  20  2........................................................................................................................................................................................................................................................................NASTSSPSQQLQQAINSTIDKECAVCYSEMILPTTIPCGHK-FCFICLKGVGDCPICRGPIDSQI...... 71
17 -18.300[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  9  1MS-DSGEPKP---------SQQEEPLPQPAAQETQSQQVCTFFKKPTKSKNIRKRTIDADEEDGDSKSESSILQNLKKVAKPDSKLYFSSGPSKSSTTTSGAPERSVFHYDSSKEIQVQNDSGATATLETETDFNQDARAIERVLKKADEALKGNKKKASDEKLYKGIHGYTDHKAGFRREQTISSEKAGGSHGPLRAS-AHIRVSARFDYQPDICKDYKETGYCGYGDSCKFLHDRGDYKPGWQIEKEWEEAEKVRKRNKAMGVEDEDDEADKDSDEDENALPFACFICREPFVDPVVTKCKHY-FCEHC-TKNKKCFVCNQPTMGIFNA.... 324
18 -17.600[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  20  1............................................................................................................................................................................................................................................................................................KECKKCKSNQLVMMINECGHP-LCKNCALNSGNCHVCNRVLRKN....... 53
19 -17.500[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  16  254...........................................................................................................................................................................................................................QALAIRKFIRTYRTKSKTRRFIEDLPSRTISREGFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESGDKVVALPCKHE---RPCVDYRHACPTCNTEVPP........ 368
20 -17.300[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  8  2.....................................................................................................AEAANVRQNLQNVPSIFEISASETLDNLIYPALSKIQEELSPLLTQRTVTTTGDLLNRRQQFASATLLTFMPYVERKLRTRITRHEDTSPWEQRLLSAFHAFHAAKAAHTFFYLVKYASNHSPIFRLLGLTLRYPSEPPKEDQWTYV-YSNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTTACSVSGYV-FCWKC-KEHGTCPVTHYPISDLVRIYET. 297
21 -17.200[R] KOG3002 Zn finger protein  ali follow..  16  1......................................................................................................................................................................................................................................MAPGGSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTN----LMYPPCGHT-LCSSCKLRVNTCPTCRYELGNIRCLALEK 106
22 -17.100[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  4  50.......................................................................................................................................................................................................................................VQEEDEEEEEEEDSERQTREYIDVLDSPVRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSFGPAVANTKSGIL-VFMDIPASTSGFSSDEVEGSLRVRKIYAS 164
23 -16.800[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  14  153...............................................................................................................................................................................................................................................................ASDEMEMHFIMCLSKPRLSYNDDVLTKDAGECVICLEE--TIARLPCLCI---KSC----RSCPEHPA............ 226
24 -16.100[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  21  681............................................................................................................................................................................................................................................................................SNEYISEHGGGTAEHTVDCAICMSDQHSYMVTPCNHV---TSCLEN-LQCPVCRSPL.......... 755
25 -15.600[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  22  333..............................................................................................................................................................................................................................................................................TVTVEQLQNSANDDNICIICMDENKKPKRLPCGHI---LSC-ERSQTCPICRLPVFDE....... 406
26 -15.300[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  16  2................................................................................................................................................................................................................................................QNGKPRSSARPSFHRRPKDGVANTTTDNAAVKPEALESYTGNDDNACVVCFKNVEIFSIGDCDH--VCYECSTRMNECPICRHVLS---KVLFTL 98
27 -15.200[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  26  6..............................................................................................................................................................................................................................................................................................CNHCGINQTKLYLTACGHV-FCQNCTKA-SQCYLCKKPLKPDLMELFKD 66
28 -14.900[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  24  6..............................................................................................................................................................................................................................................................................................CVICAELADEVFATVCGHM---HNC-DRSKTCPQCRCTTRNIFRVYFNL 62
29 -14.800[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  26  90....................................................................................................................................................................................................................................................................................KESFTVMDSQCSVCLQPNDKLQQIPCKHT---MDCIDL-TTCPLCRLALIPS....... 148
30 -14.700[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  28  224...................................................................................................................................................................................................................................................................................TKNNANNKYDTCVICLEIEDDKLVLPCSHP---THCTENRRVCPICKRKVFTKGEARASR 290
31 -14.700[O] KOG0802 E3 ubiquitin ligase  ali follow..  23  348.................................................................................................................................................................................................................................................................................DATSEELRAYDDECAICREPMAKAKRLHCNHL---LGCLNEVYSCPTCRKPLFVG....... 409
32 -14.600[U] KOG2066 Vacuolar assembly/sorting protein VPS41  ali follow..  6  557............................................................................................................................LMSRNEGTEFADKAVQL--YAEYDQKKLLPFLRKNANYNVNKARKLCSDK--GYIEETIYLLAKSGNHYDAVKMMVREYR-DPDLWIHLLGVVAEFPAHFSQLIIEAIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQGLISAADESVSVNIVSRCSLCAQIFSDIKVFKCGHI---LACSIEEGLCIACSDQIELI....... 805
33 -14.300[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  14  608..........................................................................................................................................DNVMKFSVSALEHRVYEVRETAVRIILDMYRQHQASILEYLPPDDSNTRR-NILYKTIFEGFAKIDGRATDAEMRARRKAATEEA-EKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFCGERSESFMLTRCEHLC-CYRCSEAVFKCPLCHENFEEAWKAHLMG 865
34 -14.000[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  14  262..................................................................................................................................................................................................................................................................RKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGG-RQPVKTSKC---CFSKEA-ESDFVCPNCETRKEKEVETFLKK 356
35 -13.900[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  16  2...................................................................................................................................................................................................................................................................................DDEGARKVDEKCPLCQAD-KLLINPECYH--MCESCVDRI-PTPGCNKILRKA....... 66
36 -13.900[R] KOG4299 PHD Zn-finger protein  ali follow..  8  1..MDAKPWNH---TSEAFQASILEDLKIIQKAGAERNAKSSHGSINSRSASPNKATSRRNRAQNGNSNGRASVDNSDDGSKDDLDYSPSVKRKHVNGEGAEKGDHDTSNNGPSITKLRRKVRRTYDTKDGFVAWNTLDDDFRPIVPDQERSRKINPQKGNNNNLLKENKSLKTTAKDLSDISSSSMKKA----------------NNSSKPLFSGKLTFKANIPVPTSEVVTENNVTRNVTVYSNQKHLGNESENFNDMEGRAEDISSNELLPTPEEYPYRYNNDYCSACHGP---------GNFLCCETCPNSFHTCPICNE............ 308
37 -13.800[R] KOG1312 DHHC-type Zn-finger proteins  ali follow..  13  103.............................................................................................................................................................................................................................................................LAMVSRAEDSKDHKSGSTEEYPYDYLLYYPAIKCSTCR------IVKPSKHCSICNRCVLVADHCI-CIGKGNLQFYLFLIS 185
38 -13.500[O] KOG2879 Predicted E3 ubiquitin ligase  ali follow..  12  161......................................................................................................................................DSEQRPLARRLWTLVQRIEGIYKAASFLNLLSFLGRYRNLIEKALKARLVYRSPHMNRSVSFEYMNRQL-----VWNEFSVGLLYPSIDQNILFRLATRNVMLGSDFLVLFWHSALNLFGDIQELLNSSAVKNILSPFAKDKSSSTKEDTVTCPICQVDPAIHLKELTCRR--CYYCSAASFRCLRCNEPVVAIQREGVSS 387
39 -13.300[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  14  1...............................................................................................................................................................................................................................MSESVKENVTPTRNFRRTQGPQNNTKPHNDRKNFRRKQKKNNLSAEPNLTTSSADDTDEENELCVICARKLTYVSLTPCHH--TCHICGFRQRSCLICRTENEEVM...... 111
40 -13.100[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  9  2...............................................................................................................................SQKNFFDEGKSYGVNDYAGFHFEN-QVSAQGVVRETDSSNFDASPVASGSGISDVGPFGADFHQLQQHVQTPYGGMTMPASSSSGATSVPPEQDPSLSVSFNRLPKSASTKTKNGRIRSSRREDDNRIPFYDLDVAEGAEDDLQEDLKRKSRKVDMVTLCSVCQRGHSP------NRIVFCDGCNSPYHQCPICMK............ 242
41 -12.900[S] KOG3899 Uncharacterized conserved protein  ali follow..  11  156...............................................................................................................................SAVASEIGIEFRQPEIYKKKLNSISSVIATQNKTTMYNVHFAHQSNTSLSVAKAETYNISHQDQNDTLQMISIIVRPMRQGVSDFHIRINALEFRNLENRVRRPIAIPSNIQ-----------------HRNVIDRFVDVFKAQVAQNPIFPDDATTEKCFACMLNEPNTKIHCCSN-CYCRPCVECLARCPMCRAK........... 377
42 -12.600[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  19  2........................................................................................................................................................................................................................................................SSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGDKVSGY-LLTCE--CTCQNCKTQRKRCPYCR--FQKCLSVGMKL 107
43 -12.500[R] KOG1315 Predicted DHHC-type Zn-finger protein  ali follow..  13  71..................................................................................................................................................................................................................................TYWKSIFTLPQQPNQKFHLSYTDKERYENEERPEVQKQMLVDMAKKLPVYTRTGSGAVRFCDRCH------LIKPCHHCSVCAMCVLKMDHCP-C----FSNYKFFL.. 175
44 -12.400[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  14  29...........................................................................................................................................RLKNLYNRRAERLRELAENNPLGDYLRFAALIAHAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAAAQMANLIPGKARAEYGEQRQYCPVCGSMPVSSMVLHCN-LCKCSNCEQSAESCDDCGTYLKASLVLDARM 289
45 -12.400[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  25  53..............................................................................................................................................................................................................................................................................................CSLCKTAEGDTIRLNCLHL--CATTAPAGYRCPCCSQEV.......... 104
46 -12.300[R] KOG4602 Nanos and related proteins  ali follow..  13  194.......................................................................................................................................................................................................................................................ASRGQRLETQEIEEPSPGPPLGQDQGLGAPGANGGLGTLCNFCKHNESRHVYVVCPIL-VCPVCGATLKYCPLNGGQQSLYRRSGRNS 301
47 -12.300[K] KOG2845 Activating signal cointegrator 1  ali follow..  13  1..........................................................................................................................MAVAGAVSGEPLVH--QQLRKTFGLDVSELSIESAEEIREYVTDLLQGNEGKKGQFIEELITKWQKNDQELISDPLQQCFKKDEILD-GQKSGDHLKRGRKKGRNRQEVPAFTEPDTTAEVKTPFDLAKAQENSNSVKKKTKFVNLYTRERQDRLAVALPGRHPCD-CLGQKHKLI-LICGRI-VCEQ--EGSGPCLFCGTLVCTHEE..... 212
48 -12.200[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  19  6....................................................................................................................................................................................................................................................................................KKETMRACLSCSICDN------ILRDAT--ISEKCEDEIETCPVCNIDLGST....... 56
49 -12.200[U] KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11  ali follow..  12  698.................................................................................................................................LYEKMKFYKEVIACYMQNHDHEGLIACCKRLGDSSKGGDPSLWADLLKYFGEIGEDCTK------EVKEVLTYIERDDIVLQTLAKNPCLTLSVIKDYIARKLEQESKIIEEDRRAVEKYQETTKNMRKEIED-------------RTNARIFQLSKCTACTFTDIPAVHFMCMH----QRCGDNEKECPECAPEYRSVMEM.... 887
50 -12.100[U] KOG2034 Vacuolar sorting protein PEP3/VPS18  ali follow..  11  699.................................................................................................................................IYSMMSMHEEAVALALQIDPELAMAEAEDDEDLRKKLWLMVAKHVVKQEKGAKRENIRKAIAFLKETDGLLKIEDI----------PDFALIDDFKEAICSSLEDYNKQIEQLKEEMNDATRGADNIRND------------SALTQRYAVIDRDEECGVCKRKLAPFYVFPCGHS--CSELDDAISECPFCGELMINEITLFIKP 967
51 -12.100[O] KOG2164 Predicted E3 ubiquitin ligase  ali follow..  8  2LNGEKSALGEMPSNSNSSSKLNAKSPNFIPSSSNIPRSSAKTKEHSADRKPHRNSEKKTQGMPRKNQQLASSERKTKNKKRLEKQSSAIADSIGESLDDPQTVYDEHLFDILSARTN-----------------KRGQINLNHLLNFQFTPRTNSNAFSAPPRRSRGYNTYGQGSGHHPMDKSR-----------VNANYRFVVSPIGDYQSQKLDPDSPVK---EDVWQVLCSSDF---------------------------------------------QLAACPFCLEEKVAARMSRCGHV-YCFSCKCGHRSCPICWDSIRLR....... 279
52 -11.900[R] KOG1313 DHHC-type Zn-finger proteins  ali follow..  16  108..............................................................................................................................................................................................................................................................................GTHPGVGNGALNNYTFCNYCS------KPKSTHHCRTCGMCVLDMDHCP-CKYFIAFLISAVIST 178
53 -11.700[R] KOG2789 Putative Zn-finger protein  ali follow..  11  1.......................................................................................................................................................MGNTIGKERQENDEELIQHLVQLVPQGVYSSAPAYKTNIVRKLMLERRLMPFYKGLDSYSKDWPADKVVEVVEKALGPHKSALLHCAIRQSRSLSVGNTRSLKRDSRGSSDHLLTRNRSNSTPGSISAD-ANAMECPIC------FLYYPC---CICSECFVEIRKCPYCMTERFGVI...... 220
54 -11.500[O] KOG1039 Predicted E3 ubiquitin ligase  ali follow..  15  207...............................................................................................................................................................................................................................................................EQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKILSNCNH-TYCLSCNPIIKSCPECRVIKNELIEAFKQG 321
55 -11.400[O] KOG4159 Predicted E3 ubiquitin ligase  ali follow..  29  8.........................................................................................................................................................................................................................................................................................................VTTPCGH-SFCKNCLERCPYCPLCKESLKEYLAD.... 44
56 -11.300[B] COG5034 Chromatin remodeling protein, contains PhD zinc finger  ali follow..  11  20...............................................................................................................................VSVPESVCGK-KEIDAQVRDIRQNVIQEIGVNDELSGEERCERLQKTLKEILPYSDSKICLATDAMNNIKSCIDRLDAGFEYVELEQSSYHTPTKRRKNAVPRKSSSPPLSSTKHAPQSTERRPVRRSESRLKQTNGEPLVKHDTLDSSDISREGEQLYC-YCQQVSYG--MIGCDN---CKPCVGLVEPCKECEELAKSSES..... 303
57 -11.300[R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  17 1425..............................................................................................................................NRAFTSTVESFTGYN--LISASLDDVERSIESEDFQSVGDVNNTREISFIYNVDEHKLEMAIKIPSVYPLQEGIERVGVNERQWRSWILASQSILSSQNGSITDALLVLKKNISMHFEGVEE--------------------------------------CAICY----SVL-LPCG---TCRHCSSNSSRCPLCRSSFT......... 1608
58 -11.300[R] COG5273 Uncharacterized protein containing DHHC-type Zn finger  ali follow..  16  143..............................................................................................................................................................................................................................................................QLRNNYQIPQEYYNLITLPTHSSISKDITIKYCPSCR------IWRPSSHCSTCNVCVMVHDHCI-CIGKRNRFFLIFLLG 224
59 -11.100[S] COG4260 Putative virion core protein (lumpy skin disease virus)  ali follow..  11  168...................................................................................................................KNADHVEIQEINDQYLAEFLTALNTSINQYSAQGERV-SFLTSKSMELSKYMASVLDEDWKQLR-----EIVSVAVASISYTDDSQKLINMRNQGAMLGDPSIREGFVQGAVARGLEAAGSNTGGATNAFMGMNMGGQNLAGFSQTNQAQMQAQAENKADTECNTKNTGKFCSNCGQAKPSATPVMPELNMACNECGAVVNLCPECGKPFVAK....... 387
60 -11.000[R] KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger  ali follow..  11  1..................................................................................................................................................MPEKLLKITYQGAGPQKK---INAYLRMPSQNYTILRREIELYLFQERQLPKCDVRTF------------IDADKDEIEIVNQNDYEIFLAKCESNMHVQVAPLAPVEEPKATKQEGSSANAEAPSVDDPSNFTIHDAVECDGCGLAP----LIGFRY---CVQCSN-YDLCQKCELAHKHPEHLMLR. 167
61 -10.800[B] KOG1973 Chromatin remodeling protein, contains PHD Zn-finger  ali follow..  10  36...............................................................................................................................ESLPTELERN-RKLDDRAQTAMKSIDSHAKDMSEDERRERQEDIKALFGKAKEYSDDKVQLAIQTYELVDKQIRRLDNDLARFEGEQSNANSSVNSSSNAGQGSKKKKSKVNQEKETRKGGAQKKTVEVDDSEKESCHTAATHPSDVMDMPVDPNEPTYC-LCHQVSYG--MIGCDN---CPACVGLTTKCPKCTQDRKK........ 327
62 -10.800[R] KOG1314 DHHC-type Zn-finger protein  ali follow..  14  90...................................................................................................................................................................................................................................................................................EISQDTMYLQYCKVCQ------AYKASHHCRKCNRCVMKMDHCP-C----YQNHASFT.. 145
63 -10.800[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  27  328............................................................................................................................................................................................................................................................................................KCCNICGTSENDDQLLFCDD---CMYCTPSMSECHLCLDLLKEKASI--SS 391
64 -10.700[O] KOG3579 Predicted E3 ubiquitin ligase  ali follow..  12  425........................................................................................................................................................................................................................................RRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCCTLCHERLEDTHFVQCSHFCFCSRCPSG-EKCPLVGSNVQGEIATILAG 550
65 -10.700[K] KOG3815 Transcription factor Doublesex  ali follow..  17  2...................................................................................................................................................................................................................................................................NGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWL---GHKRYCKDC-----TCEKCRQRVMAA-QVALR. 75
66 -10.600[R] KOG1311 DHHC-type Zn-finger proteins  ali follow..  16  75................................................................................................................................................................................................................................................................GSEEPTQVDDLRAPLYKNVDINGITVRMKWCVTCK------FYRPSSHCSVCNRCIETFDHCP-C----KRNYRYFF.. 149
67 -10.500[O] KOG3268 Predicted E3 ubiquitin ligase  ali follow..  8  92...........................................................................................................EVALKNRQELYALPPPPQFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAEDASGREHLITLKTPQSSLISIYSQFLAAIESLKAFWDVMDE-LEPEKPPRSATARRIALGNNVSINIETMLPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEKSDFTMDCGICYAYQLD---IPCGH----QICNIIFGECPYCSKPITLKMS..... 371
68 -10.500[C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit  ali follow..  11  98..................................................................................................................TIWEGEQLERHLPAAMREYIAKNNIQF---YTLNAMRIAGEAGLGRRINTEKALADLKASAIATYGKKDMAVAEKNILAMDQTANLHKVEVPESWANPVLTAEASTATEKPAYVKNILEPVNRL-----EGDNLTVGDLISNGMVSGAYPPGTAAYEKRGIALEVPEWISENCTMCN-----ECAFVCPHAAICTGCNLCAETCP----AKDKALVM.... 351
69 -10.400[T] KOG3575 FOG: Hormone receptors  ali follow..  15  5...............................................................................................................................................................................................................................................................KMHVNMLQSDHALIMSSFPEPSPSSKRPTENCKVCGDRPNN--ASACL--CKCQNCL---NACRYCR--FQKCFAVGMHS 103
70 -10.400[O] KOG1734 Predicted RING-containing E3 ubiquitin ligase  ali follow..  16  271...................................................................................................................................................................................................................................................TARMASRIGYYTPEGLPKKHLEDGVCAVCGGRLDDSEHVHDADAVVTTKMDEKLYKLSCGHV---EFCVGKLQTCPYCKERVD......... 362
71 -10.300[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  11  4..............................................................................................................................VEVESDNKHLVADELIALQSIYPEIH-----DGNNYGRLNIPVNTESDYFLSFKSPDESTLTDTIVVRHFPDLVMEFFL-KSSW------PLKQKRVLTSSLIKLWNEIHDCVLFDAIEHVRSIATIAFHLPTEMVFPGGFDDAFDKNAKLLEFQIRKFQCNVCFDETDCFQLTRCGHV-SCQSCTMCIQECI-CGKDAPKELESIVGV 242
72 -10.200[OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex  ali follow..  11  11..................................................................................................................................................................................................................................................DEDESQNIAQSSNQSAPVETKKKRFEIKKWTAVAFWSWDIAVDNCAICRNHECVAAWGVCNHA---LHCINK-DACPLDNQPWQ......... 115
73 -10.200[DO] KOG1493 Anaphase-promoting complex (APC), subunit 11  ali follow..  30  72..............................................................................................................................................................................................................................................................................................CGICRMEDDCPLVLGCRHA--CAPTNQPRAQCPLCRQDWT......... 132
74 -10.100[K] KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors  ali follow..  10  2.............................................................................................................................................................................................................................................DMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATG------KHASSCDGCKGFFNQCRYCR--LKKCFRAGMKK 118
75 -10.100[O] KOG2824 Glutaredoxin-related protein  ali follow..  35  227..............................................................................................................................................................................................................................................................................................CHCCG----DIRFVPC--NC-CPECENGLIRCPDCSS............ 274
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.