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Query: [P] KOG1161 Protein involved in vacuolar polyphosphate accumulation, contains SPX domain, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLFGVKLANEVYPPWKGSYINYEGLKKFLKEDSVKDGSNDKKARWDDSDESKFVEELDKELEKVYGFQLKKYNNLMERLSHLEKQTDTEAAIKALDADAFQRVLEELLSESTELDNFKRLNFTGFAKIVKKHDKLYPKYPSVKSLLEVRLKELPSHSEEYSPLLYRISFLYNILRSNFNTASEPLASASKFSSIVSNDIDMNFRSFKFWVHNDNLMEVKTRILRHLPVLVYANVPSENDDLVNRFESDISNNDEIVGSSSSTSSVEHGLGARSFDPLINTLYFDNEHFELYNDKLLKLNSAPTLRLRWTGQLSDKPDIFLEKKTLIEDEATGKSEFDLTKLQLKQKFINGFIFEGDKKFKEQTLKKLKESGTAGRDLERLEEDFSEIQNFIIKNELQPVFRTVYTRTAFQIPGDDKIRVTIDSNIVFIKEDSFDRERPIRDPNTWHRTDIDANVANPLKFLRGGEYAKFPYSVMEIKVKSSLDSSMSASSMISNVKLPKKHGQWLNDLTNSHLVKEIPKFSIFVQGVASLYGDDEKLDILPFWLPDLETDIRQDPKQAYEEEKKKLLKQKEIQKKIDGMRRLSNLKEPQHQAAVPVSQEENERITSQGDLEADGSSDEETEQEPHSKRSKKVRRRKPKATFLRILAGRDPKLMGVDSEEEEIELPPGVKKPLNLLLast
1 -164.000[P] KOG1161 Protein involved in vacuolar polyphosphate accumulation, contains SPX domain  ali  100  1MLFGVKLANEVYPPWKGSYINYEGLKKFLKEDSVKDGSNDKKARWDDSDESKFVEELDKELEKVYGFQLKKYNNLMERLSHLEKQTDTEAAIKALDADAFQRVLEELLSESTELDNFKRLNFTGFAKIVKKHDKLYPKYPSVKSLLEVRLKELPSHSEEYSPLLYRISFLYNILRSNFNTASEPLASASKFSSIVSNDIDMNFRSFKFWVHNDNLMEVKTRILRHLPVLVYANVPSENDDLVNRFESDISNNDEIVGSSSSTSSVEHGLGARSFDPLINTLYFDNEHFELYNDKLLKLNSAPTLRLRWTGQLSDKPDIFLEKKTLIEDEATGKSEFDLTKLQLKQKFINGFIFEGDKKFKEQTLKKLKESGTAGRDLERLEEDFSEIQNFIIKNELQPVFRTVYTRTAFQIPGDDKIRVTIDSNIVFIKEDSFDRERPIRDPNTWHRTDIDANVANPLKFLRGGEYAKFPYSVMEIKVKSSLDSSMSASSMISNVKLPKKHGQWLNDLTNSHLVKEIPKFSIFVQGVASLYGDDEKLDILPFWLPDLETDIRQDPKQAYEEEKKKLLKQKEIQKKIDGMRRLSNLKEPQHQAAVPVSQEENERITSQGDLEADGSSDEETEQEPHSKRSKKVRRRKPKATFLRILAGRDPKLMGVDSEEEEIELPPGVKKPLNLL 675
2 -116.000[P] COG5036 SPX domain-containing protein involved in vacuolar polyphosphate accumulation  ali follow..  28  1MKFGQLLKETLMYEYKYSYVNYDKLKKEIKRRNDQ-------GGWSEEDESDFVELLEKELDKVYSFQKNKSAEVMERIRFCEEQTDEVNPPNENDFAILETELTDIMATVHDLAKFSELNYTAFYKIIKKHDKHTGWILKPVFAAR--LNAKPFFKEQYDLLVVKLSKLYDFVRTRGSPIKGDSAAGGTQQN-------FVRQTTKYWVHPNNVTELKIYILKHLPVLVFNPNKEFARED----------------------------------AAITSIYYDNDDLDFYLGRLEKREGAEAIRLRWYGN-MDNNNIFVERKTHREDWTG--EKSVKARFPLKEKYVNAFLRGD-YTVEEAFAKMRKDGKKSLKEIESLERLAKEVQYTVLSRGMKPYVRSFYERTAFQLPGDARVRISLDTNLSLIREDGPS-----RAGNNWRRMDIGI--DYPFDQLPDEDIVRFPYAILEVKLQT---------------QFGQDPPEWVNNLVNSHLVEAVPKFSKFIHGVSTLFYD--RVTLLPYWFPQMDIDIRKPATHTFIQGRSQSGTHSSSVSANVLTDSENTPIHADGDNYVDEESRIGSSSTRNDNSTFQTSDSFQELDERTNLLDISKRKGRDSFVAALNSRLKDIKDSFFLETVPKFEEPT--VSP.... 608
3 -55.200[T] COG5408 SPX domain-containing protein  ali follow..  20  1MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKTRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNAN--ANDNTEFFKIICVFIEEDDSKGLIRELTNLYSELSLIPTR........................................................................................................................................................................................................................................................................................................................................................................................................................................................ 300
4 -30.000[U] KOG1162 Predicted small molecule transporter  ali follow..  23  2VKFSKELEAQLIPEWKEAFVNYCLLKKQIKKIKTSRKPKPASHFSEEDEVKVFFARLDEELNKVNQFHKPKETEFLERGEILKKQLETLAELKQSAEKKIRSAFVELYRGLGLLKTYSSLNMIAFTKIMKKFDKVAGQNASSTYL-KVVKRSQFISSDKVVRLMDEVESIFTKHFANNDRKKAMKFLKPHQTKDSH............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 383
5 -11.500[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  23  3............PGWGEAAIQYKALKKCIKRFVFELSSLGLSAETISKCDHEFFEKLTSELQSVEGLQREQRKILFNAIDILSHEISLIASPNSKRDRILYAKFLELNESLLKVASFQQMNKLAVTKIMKKFDKRTSLTAQP..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 319
6 -7.820[K] KOG4796 RNA polymerase II elongation factor  ali follow..  11  530IKYIA--RQNYKDDFNAEYDEYRALHARMETVARR------------------FIKLDAQRKRLSP--SKEYQNVHEEVLQEYQKIKQ----SSPNYHEEKYRCEYLHNKLAHI-----------KRLIGEFDQ............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 633
7 -7.670[R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein)  ali follow..  10  349..YSLKVGGERV--WGDNYVDGKLVEYQRESNASFDDKNQKGGDKLEGIKLEYTLLLTSQLEDQRKYFEGLRHDMEQTMSKMEKTAYAQVENLEHQLTERSTELKSLKGDLDDTVTARKVAEKRATQTNEKVNKLANELKDEREINQMLRKDQQVWKGQVEKLIKKIEDLQSQVNDLLMHFETQNKLKEQLDAGKITQEEITESQV..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 572
8 -7.490[U] KOG3745 Exocyst subunit - Sec10p  ali follow..  8  236.DMASLFEQACLDEFELGL-NLDLLRKFSHVLHDFSGPNAYVSMYLAKQTNDTIKLLESESKFSEATLPEPELVQVPYAKDILGN-------------SLKDYVISICEHIGEEETFLVFISGFYGLCKKFFSIPNGPALVDTIFQPQI---DIFISQELHYFKTVGWSLVDQWDQKLEEKEDATECFFYKNVSQNTAKNNFLETFKNVMLLPVSLFTIPSENNSASNLAEKAIEQKEEEDPELSKLDAARFVPANIYVSKDRLKHLPTTELAAQAAVLDSKLEGISTMFSLEKIVHLCKVSLARAKVFMGTSVPQDDDIKGLS--------KDLFVQLLRELGQGHLKHGFDRAIEHLSSFDPRRDFSSNTVEPVVKNVGDMIQQMMDSFFNEEMSPICPAIAEKKKFEQLLDERAAFGLHKGINVLIEHADFLLETKTPMNLFSDQTIGSITNTIEPTAAAKNVVQFLGFHMRI---------------LVGRADHEILDVFYKEVLFDSLTRYIKSHKFSVDGGLKLLSD.............................................................................................................................................. 784
9 -6.750[U] COG5308 Nuclear pore complex subunit  ali follow..  6  714LLITRLFS----QIWEERVFV-----------FKRASKTEKMDAFGISITRPQVEYYLSSISVLADFFNIHRPSFVSFVPPKGSNAITASDAESIAMNALILLINSIKDALSLINVFYESLLNTLMGAGGVYDS----------------TREYFFDLKFHDLFTPNAKTKQLIKEILIEVVNANIASGTSADY----VNVLKERFGSFCHSADILCYRAGEHLEAAQKFEMIDSKISRNHLDTAIDLYERCAENIELCELRRVVDIMVKLNYQPKTVGADKIDKGNQAQVSRGCNTADPRKVFRINVYTLIFEIVKSVDDYTSIEQSPSIANISIFSPASSLKKRVYSVIMNSNNRFFHYCFYDWLVANKRQDYLLRLDSQFVLPYLKERAEKSLE-LWFYLFKEEHFLEAASSDFDLKLSERIECLARANGLCDSSTSFDQKPALVQLSENIH------ELFDIASIQDDLLNLVRNETRIDEDYRKQLTLKLNGR------LSDLFNDC----ADPLDYYEIKLRIFFKDEKVIQGE--WNRLLDSMKNAPSPDVGSVGQESFLSSISNT...................................................................................................... 1268
10 -6.560[OT] KOG0505 Myosin phosphatase, regulatory subunit  ali follow..  16  880RDY-KKL-------YESALTENQKLKTKLQE------------------AQLELADIKSKLEK---VAQQKQEKTSDRSSVLEEKRERRA---ERKMSEMEEEMKNLH-QLKQIQTLKQMNEQALTRVVARLSESIE.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 991
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.