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Query: [U] KOG1162 Predicted small molecule transporter, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVKFSKELEAQLIPEWKEAFVNYCLLKKQIKKIKTSRKPKPASHYPIGHHSDFGRSLFDPVRKLARTFSDKLFSNSEKPEILQVRRRRGSSETGDDVDEIYQTELVQLFSEEDEVKVFFARLDEELNKVNQFHKPKETEFLERGEILKKQLETLAELKQILSDRKKRNLSGSNSHRSFSSSVRNSDFSAGSPGELSEIQSETSRTDEIIEALERNGVSFINSATRSKTKGGKPKMSLRVDIPDAVAGAEGGIARSIATAMSVLWEELVNNPRSDFTNWKNIQSAEKKIRSAFVELYRGLGLLKTYSSLNMIAFTKIMKKFDKVAGQNASSTYLKVVKRSQFISSDKVVRLMDEVESIFTKHFANNDRKKAMKFLKPHQTKDSHMVTFFVGLFTGCFISLFVIYIILAHLSGIFTSSDQVSYLETVYPVFSVFALLSLHMFMYGCNLYMWKNTRINYTFIFEFAPNTALRYRDAFLMGTTFMTSVVAAMVIHLILRASGFSASQVDTIPGILLLIFICVLICPFNTFYRPTRFCFIRILRKIVCSPFYKVLMVDFFMGDQLTSQIPLLRHLETTGCYFLAQSFKTHEYNTCKNGRYYREFAYLISFLPYFWRAMQCVRRWWDESNPDHLINMGKYVSAMVAAGVRITYARENNDLWLTMVLVSSVVATIYQLYWDFVKDWGLLNPKSKNPWLRDNLVLRNKNFYYLSIALNLVLRVAWIETIMRFRVSPVQSHLLDFFLASLEVIRRGHWNFYSGELast
1 -167.000[U] KOG1162 Predicted small molecule transporter  ali  100  1MVKFSKELEAQLIPEWKEAFVNYCLLKKQIKKIKTSRKPKPASHYPIGHHSDFGRSLFDPVRKLARTFSDKLFSNSEKPEILQVRRRRGSSETGDDVDEIYQTELVQLFSEEDEVKVFFARLDEELNKVNQFHKPKETEFLERGEILKKQLETLAELKQILSDRKKRNLSGSNSHRSFSSSVRNSDFSAGSPGELSEIQSETSRTDEIIEALERNGVSFINSATRSKTKGGKPKMSLRVDIPDAVAGAEGGIARSIATAMSVLWEELVNNPRSDFTNWKNIQSAEKKIRSAFVELYRGLGLLKTYSSLNMIAFTKIMKKFDKVAGQNASSTYLKVVKRSQFISSDKVVRLMDEVESIFTKHFANNDRKKAMKFLKPHQTKDSHMVTFFVGLFTGCFISLFVIYIILAHLSGIFTSSDQVSYLETVYPVFSVFALLSLHMFMYGCNLYMWKNTRINYTFIFEFAPNTALRYRDAFLMGTTFMTSVVAAMVIHLILRASGFSASQVDTIPGILLLIFICVLICPFNTFYRPTRFCFIRILRKIVCSPFYKVLMVDFFMGDQLTSQIPLLRHLETTGCYFLAQSFKTHEYNTCKNGRYYREFAYLISFLPYFWRAMQCVRRWWDESNPDHLINMGKYVSAMVAAGVRITYARENNDLWLTMVLVSSVVATIYQLYWDFVKDWGLLNPKSKNPWLRDNLVLRNKNFYYLSIALNLVLRVAWIETIMRFRVSPVQSHLLDFFLASLEVIRRGHWNFYSGE 755
2 -80.700[T] COG5409 EXS domain-containing protein  ali follow..  21  1..............................................................................................................................................................................................................................................................................................................................................................................................SANSMRFGLLFGAGLPLAIEAACYY---------NATEQSSYLLQIWGGFFLVIFAFVLFDLDCYVWEKTRVNYMLIFEFNQRKSLNWRQHLEIVGAVFFIFSLFFFLCMRNFFPGFT----IYFPALFLGVVGTFLIAPVIVPYWRMRRYLIIQLIRVFLSGLSTVHFQDFFFADQMVSLTYACGNISLFFCLYKRLW-----RQPQLCNSSHSPLLGFFTTLPGILRVFQCFRRYSDSLKFPHLVNALKYIFNILAQMFLSLWRIHPGLKYRVLYTIFAGVNSLFSYTWDILMDWNLLVRKDGRWQFREHRILKQLWPYIIAMILNFIVRSSFIFYCIF-PNHIQHSSGISFFVTLAEIMRRCMWNILRVE 355
3 -49.600[T] COG5408 SPX domain-containing protein  ali follow..  20  1.MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHNKNSYD-------------------------------------EGRPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTRE-----------------------------------------------------------------------------------MNMLLKGTSQASRLSYHKDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMTRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANAND.................................................................................................................................................................................................................................................................................................................................................................................... 263
4 -30.000[P] KOG1161 Protein involved in vacuolar polyphosphate accumulation, contains SPX domain  ali follow..  23  1.MLFGVKLANEVYPPWKGSYINYEGLKKFLKEDSVKDGSNDKKA----------------------------------------------------------------RWDDSDESKFVEELDKELEKVYGFQLKKYNNLMERLSHLEKQTDTEAAIK---------------------------------------------------------------------------------------------------------------------------ALDADAFQRVLEELLSESTELDNFKRLNFTGFAKIVKKHDKLYPKYPSVKSLEVRLKELPSHSEEYSPLLYRISFLYNILRSNFNTASEPLASASKFSSIVS.................................................................................................................................................................................................................................................................................................................................................................................... 196
5 -28.400[P] COG5036 SPX domain-containing protein involved in vacuolar polyphosphate accumulation  ali follow..  22  1.MKFGQLLKETLMYEYKYSYVNYDKLKKEIKRRNDQGGWSE-----------------------------------------------------------------------EDESDFVELLEKELDKVYSFQKNKSAEVMERIRFCEEQTDEVVRRLDSDNPPNENDF--------------------------------------------------------------------------------------------------------------------AILETELTDIMATVHDLAKFSELNYTAFYKIIKKHDKHTGWILKPVFAARLNAKPFFKEQ-YDLLVVKLSKLYDFVRTRGSPIKGDSAAGGTQQNFVRQTT................................................................................................................................................................................................................................................................................................................................................................................. 197
6 -14.900[R] KOG2295 C2H2 Zn-finger protein  ali follow..  8  175MRKYTEYFVAHKDEEWKNKYVDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFLRNLA------SITRSEIEAVCNRFSGYLRVAIADPLVER---ITFMRDVNIKEICWGLNNQRLRDCEMG-NRDLSRRVRPANGITAHKQVVRSDIKLCAKIALNL.................................................................................................................................................................................................................................................................................................................................................................. 625
7 -13.300[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  13  1............MPGWGEAAIQYKALKKCIKRFVFELSSLNASNMITTVRSNYASNVPSTPSDSTQQPPTNTLPSVSASSQSVETCETVDEDIDTQTMSSDMSEVQSMEISLNCDHEFFEKLTSELQSVEGLQREQRKILFNAIDILSHEISLIASPNSKKKYKSLYCWRK--------------------------------------------------------------EIYMDSDIFISCKEADQSHERTPELAERHLKWFDDQVRLAKCLPSSSKHRDRILYAK-FLELNESLLKVASFQQMNKLAVTKIMKKFDKRTSLTAQPLFFQVIESDPLLLVDNASKAICFSLS............................................................................................................................................................................................................................................................................................................................................................................................................... 345
8 -11.700[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  10  28....TRRLSDLRVADVRKRNVDSSGNKSVLERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVA--PVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTS..................................................................................................................................................................................................................................................................................................................................................................................... 492
9 -10.700[K] KOG4796 RNA polymerase II elongation factor  ali follow..  8  258.YTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKLNPSQNATGTSRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKKARISHLTNRVPPTLNGHLNPTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPISHPPQIVNSNSNSPSTPEGRGTQDLPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLKCPKPMEENHSMSHKKSKKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDCTASMEPSAIELPDYLIKYIAIVSYEQRQNYKDDFNAEY------DEYRALHAR-METVARRFIKLDAQ------RKRLSPG----SKEYQNVHEEVLQEYQKIKQSSEEKYRCEYLHNK.......................................................................................................................................................................................................................................................................................................................................................................................... 620
10 -10.500[K] COG5641 GATA Zn-finger-containing transcription factor  ali follow..  10  132.....KNCLTSTTPLWRRDF--LKSLKT-IKSRNRKSNTNHAHNLDNFRNQTLIAELKGDCNIESSGRKANRVTSEDKKKKSSQLLMGTSSTAKISKKPKTESKERSDSHLSATKLEVLMSGDCSRPNLKPKLPKQDTAIYQEKLLTFPSYTDVKEYSNSAHQSAFIKERSQFNAASFPLNASHSVTSKTGADSPQLPHLSMLLGSLSSTSISNNGSEIVSNCNNGIASTAATLAPTSSRTTDSNPSEVPNQIRSTMSSPDIISAKRNDPAPLSFTRDRAISNVKTETTPPHFIPFLQSSKAPCISKANSQS-SVSSSDVSGRKFENHPAKDLGDQLSTKLHKEEEIIKLINELEDLYRRHINELDGKCRALEERLQRTVKQ..................................................................................................................................................................................................................................................................................................................................................................................... 545
11 -10.200[T] KOG2290 Rhomboid family proteins  ali follow..  7  89...FGVSKDSDSTQKWQRKSIRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRARRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPYRTYRKRIDSFVKRWLTFVHSLVTILAVCIYGIAPV-ETVDSVLRNRGVYENVKYVQQENFWIGPSSEALI-HLGAKFSPCMRQD--PQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQ-------SEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITS-----------------------------------------------------------------------------REYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEFYRLWLSL--FLHAG-ILHCL----VSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFELFQSWQILARPWRA--FFKLLAV-DNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLG........... 813
12 -9.810[K] COG5164 Transcription elongation factor  ali follow..  8  1MSD-----NSDTNVSMQDH--QQFADPVVVPQSTDTKDENTSDKDTVDSGNVTTTESTERAESTSNIPPLDGEEKEAKSEPQQPEDNAETAATEQVSSSNGPATDDAQATLNTDSSEANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDDDEDDDDEAPTKRRRQERNR------DIEAEVSDDEDEDEDEEDSELVREGFITHGDDEDDEASAPGARRDDRLHRQLDQDLNKTSEEDAQRLAKELRERYGRSSSKQYRAAAQDGYVPQRFLLPSVDT---TIWGVRCRPGKEKELIRKLLKKKFNLDRAMGKKKLRDNYTGRIYIEAPKIEKFCNGVPDIYISQKLLIPVQELPLLLKPNKSDDVA.................................................................................................................................................................................................................................................................................................................................................................................... 381
13 -9.730[TA] KOG1902 Putative signal transduction protein involved in RNA splicing  ali follow..  9  1............MPR-MREMADLDAVHLGLDENEADIAEELQDFEFNTRSEASESNGGDSSDSEPSISSVSTATSSLAGSSKRKTKKPAKQSPQPAVETKSSKSSAKNKAKREPTPEELNGGKKKKRTDSGTKKTTSSEASDKVKSKSPDTEDRQPSAKKSRTKIPSNANDSAGHKSDLSEAEDEKPSLPTLESDSESSDSDSGTQHKRNGGNGGGNGRGKPSSKSSTPEKDSVGGGTHSHSQKGYDYMTKLNYLFRDTRFFLIKSNNSDNVQLSKNKATLPQNDANLNQAFKE--RNVLLI--FS-VNESGFARMAAPSRELSFNATLHLHNTWNEGKPVKIGRDGQEIEPKIGGELCRLFPEDEQIELTPILKKSKETARVMRE................................................................................................................................................................................................................................................................................................................................................................................. 416
14 -9.610[OT] KOG0505 Myosin phosphatase, regulatory subunit  ali follow..  10  639..........................ARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSD-MEKRERRA-----------LERKMSEMEEEMKNLLKQIQTLKQMNEQLQAENRALTRVVARLSESIE.................................................................................................................................................................................................................................................................................................................................................................................... 991
15 -9.470[A] KOG0150 Spliceosomal protein FBP21  ali follow..  7  1MTEY-----------WKSNFCDFMNVAKRITDISRNSEKSERERQKMDAEIRKMEEAAMKSYAQDVHSRGDMTARSINTVMRATATAAASGGAHSFAGRSRQVDPMRLEGLSDEEEDQRRVAPGKVTSDAAVPEASLWVEGKSDEGHTYYWNVKTNESVWKPPKEGYLSYEEYERINQLAIDQQQISQAEESLKFRANVDEEVARVNREKMKAFRRTDNPKEKKQKEERRQTFKTEEEAATKEIGQWQTVEVKAPEQPIDWQLPKTDYYSAAPVVSASSEPEPPVKKFKEKTIG-----GLDEEIAATAPATFKR--KFIRKGNSRQRAED........................................................................................................................................................................................................................................................................................................................................................................................................................................ 338
16 -9.470[OJ] COG5193 La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation  ali follow..  7  1.MSHKEPSAAETSTVVHSE----EDKAFCIGTGAVISEEREKEVLKNLQNSLTGKTAEENLNDEANHTSSDKSKSEDYQPSNVNVWALRKEKMIPKKHSHVKQEKRFSKSLQLQDPNVWPSPEIAEKQVEDRKLSDDSQKPLAPKANGKEKWVTITPNFTHTPISNRKSSRSRNDGSRRNGNGRRRGNYSSHGSNKRQTNYSREKDASRSIDSSNPSAEYRDDINNTFGSQTVSSANGKEVPQTSEDSSSQAPHHSSSSGHAPSQQGGNKHSYKKSDNPYLCDVQAFLTSQL-EYYFSIENLCKFKHMDDEGYVPLLASFNRIKSF-----------------STDLNLLHAACKASDIIDVAIDLQSPMSIKVRRKET........................................................................................................................................................................................................................................................................................................................................................................................ 408
17 -9.330[S] KOG2885 Uncharacterized conserved protein  ali follow..  9  16...FDGLLA--LIP--AKYYYD-KKTKEQSKNDKLKKLDPEQRDDETSSTLEVMKKKEKDAKPVVLPGEKFKHMKMQKQKEATSKVEGDSDLNVEVNDPMIIAPDEDEEEEEDIKVIFDDEGNEIPLESKK--EEEKLQRKKNLEALRSKLQAKISDMKSKRKAPGSREAILAQRKRKEELKKRKRLESEQEQDQDEIASDSDMEDIDSDLENNSKKRFKKGKKDSEINADGVMFQNIIFDDGARATSDLQRLRKAGRTKGPAKNDVKSHLKLLEAKKNKMEAKDELEQIKQKEKEKWQKAMLQAEGIKIRDDEKLLRKAIKRKEAQKRKSAIEWSERKRVVEDTISERQKRREENLRIRKDNKGKKRNKQEKMKRKYVGSA..................................................................................................................................................................................................................................................................................................................................................................................... 412
18 -9.270[R] KOG2507 Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains  ali follow..  10  68..QFMSLYKIVPIPS---FFIGKTGTPLEISVDELTEKIDKVLILAGKRTEPVAASSSSCAKTLDPNEVRSFAGADGSSSTGESQVVQTASENFRDPETTSVSNSPTGGVEEAKTNPPNSPVAASLASIPAAVSTSSLEGKSGSEAEAASPTALAAEKRAAASKVEGSATTSGAAARNFATNNLIPAVPLMTPAVPVPTQRPLEAQDNTESEERLAEVRNILEQKRKERVEEEKRMEKENELRRRRDGREAQSQQARAKEQELKNMQEQIKRERQEELAARERIRAQIAADRAEQAQRFNTPDISSTTNSVAATAASNVITTDASVSSVDETRLQIRTKSFPAGEVLATVRVYVRN--RREFQTEDEVKTLNELNLVPNAV...................................................................................................................................................................................................................................................................................................................................................................................... 473
19 -9.210[L] KOG4762 DNA replication factor  ali follow..  7  1.......MAQPSVAAF------FTNRKRAALDDAISIKNRRLVEPAETVSPASAPSQLPAGDQDADLDTLKAAATGMRTRSGRTARLIVTAAQESKKKTPAAAKMEPHIKQPKLVQFIKKGTLSPRKQAQSSKLDEEELQQSSAISEHTPKVNFTITSQQNADNVQRGLRTPTKQILKDASPIKADLRRQLTFDEVKTKVSRSAKLQELKAVLALKAALEQKRKEQEERNRKLRDAGPSPSKSKMSPRHTDVSKRLLFSPAKNGSPVKLVEVPAYKRYASLVESSRAGQLPLPYKYRHL--LDVFKGLDSV---AMFHNRKETITFKKLKPAVQRMLRKNFTETH-----LAQIKHIYPDAFI........................................................................................................................................................................................................................................................................................................................................................................................................ 380
20 -9.100[R] KOG4227 WD40 repeat protein  ali follow..  11  563........SSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLV---TGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPH--------QNLGELEVVAYSSLLHK-SEMACETPNAGTREDPTDTPATDSSRLKRQRIELED------TDSENSSSEKKLKT........................................................................................................................................................................................................................................................................................................................................................................................... 942
21 -9.020[F] KOG1096 Adenosine monophosphate deaminase  ali follow..  8  5VCKMT---SARLVPTLVLFYFEF---ELSTNQLKAVGRYLRLKRNPILFNGTQETFSKSLFNFPHFPYRQNVEKCVGRILKNAEDTNGVHFFNPAADNSDEETTAASPSSDVARPNPLDSAREYGMNNLPPDITEAQIETVDS-------------------ELFDSGPFKKNFAFGNADHSTASPFEISTTPIEVNESRAHKTIEISNREKGAKSRRWSCLARLESQNDGCLSPSSLKSVLDEIQTEPRCKSPQHIDLHTFRDAVDVNYQRMAITGEELSGVPLEDLKTASGHLIEALHLRSKYMERIGNQFPSTTRNFEKIYHLRRNRGVTEICNDDGSIDQQTKEEFLNDTEKLTAMIVDGPLKSFCFRRLSYLENK....................................................................................................................................................................................................................................................................................................................................................................................... 411
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;