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Query: [Q] KOG1204 Predicted dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGKVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQREYGADKFVYRVLDITDRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIVSLVALCLPLLKSSPFVGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKVRAVCIAPGVVDTQMQKDIRETLGPQGMTPKALERFTQLYKTSSLLDPKVPAAVLAQLVLKGIPDSLNGQYLRYNDERLGPVQGLast
1 -96.800[Q] KOG1204 Predicted dehydrogenase  ali  100  1MGKVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQREYGADKFVYRVLDITDRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIVSLVALCLPLLKSSPFVGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKVRAVCIAPGVVDTQMQKDIRETLGPQGMTPKALERFTQLYKTSSLLDPKVPAAVLAQLVLKGIPDSLNGQYLRYNDERLGPVQG 263
2 -76.800[R] KOG0725 Reductases with broad range of substrate specificities  ali follow..  14  2..SCALVIGATSTLGKAVVRRLAFTGYKVAAAADCPNSVGKVAEDNIKVGGDVTAFSLDVANAEHRKELITKVAEKLGGLDTLIIVPPQNEVLGEI----IETSGEDFDKLFANNLTTPFRLSQAAMSTLAKSQ-NGSIIYLTSCFGFTPSIDMGLYSVASSSVLSLTKSVAQSAAKQGVRVNSVVSGMIEGDGTGAVWDHASGEE-ARQIKQHLESMIPLGRLGRPSDVASYVEFLA-STKARYITGENCIVGGGVSYRL.. 253
3 -75.300[IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  23  6.GKTALITGASQGIGEGIARVFARHGANLILLDISDEIEKLAD-ELGGRGHRCTAVKADVRDFASVQAAVARAKETEGRIDILVNNAGVCRL-----GNFLDMSEEDRDFHIDINIKGVWNVTKAVLPEMIKRK-DGRIVMMSSVTGMVADPGETAYALSKAAIVGLTKSLAVEYAQSGIRVNAICPGYVRTPMAESIARQSNPDD-PESVLTEMAKAIPLRRLADPLEVGELAAFLA-SDESSYLTGTQNVIDGGSTLP... 256
4 -69.800[R] COG4221 Short-chain alcohol dehydrogenase of unknown specificity  ali follow..  22  7.GKIAVITGAASGIGLATTEALLEQGATVVMVD--WNEKALNDLAAKL-GERAIPQVTNLLDADSCNAMIPEILGKVDHIDILYCNAGTY-----IGGDLTETTPEAIDKMLNLNVNAVMKNVQAVVPHMSERK-TGDIIVTCSIAGHFPTYWEPVYSGSKWAITSFVQGMRRQMIPHGVRVAQVSPGPVVSALLADWPE------------ENLRKAKESGSLIDASEVADAVVYML-TRKRTVTIRDMLVLPTNFDR.... 242
5 -68.200[I] COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)  ali follow..  15  6.GKRILVTGVASSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAA-QLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNP---GSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDF-------RKMLAHCEAVTPIRRTVTIEDVGNSAAFLC-SDLSAGISGEVVHVDGGFSI.... 253
6 -67.900[I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase  ali follow..  18  76.SPVVVITGASRGIGKAIALALGKAGCKVLVNYARSAKEAEEVAKQEEYGGQAITFGGDVSKATDVDAMMKTALDKWGTIDVVVNNAGITRD-----TLLIRMKQSQWDEVIALNLTGVFLCTQ------------GRIINISSVVGLIGNIGQANYAAAKGGVISFSKTAAREGASRNINVNVVCPGFIASDMTAEL---------GEDMEKKILGTIPLGRYGKAEEVAGLVEFLALSPAASYITGQAFTIDGGIAI.... 308
7 -56.400[R] COG0300 Short-chain dehydrogenases of various substrate specificities  ali follow..  20  3.KKTIFITGASSGLGRQLAIDFSWEETVLCLFARSQERLENVQRIVVENGGEAHIYPVDLADPQSIDRSFAEAISAVGVVDVLINNAGY-----GVFEPFCDSQMDENERMFRVNVFGLMRATAAVLPTMREQG-SGHIINIASQAGKIATAKSAIYSATKHAVLGFTNSLRMELKGTGIHVSAVNPGPIQTPFFDQADKEGAYTSKVQR------------IMLDPEDVSEKIVQLTKKPKRELNLP............... 231
8 -53.100[I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes  ali follow..  18  322.NKVVVVTGAGGGLGKSHAIWFARYGAKVVVNDIKDPFSVVEEINKL--YGEGTAIPDSHDVVTEAPLIIQTAISKFQRVDILVNNAGILRD-----KSFLKMKDEEWFAVLKVHLFSTFSLSKAVWPIFTKQKS-GFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAKRGIIVNVIAPHAETAMT------------------KTIFSEKELSNHFDASQVSPLVVLLASEESGRRVIGQLFEVGGGWCGQTR. 560
9 -52.300[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali follow..  27  5.NNTVLITGGSAGIGLELAKRLLELGNEVII--CGRSEARLAEAKQQLP--NIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKK---GTEELFVDGDEIELNFQAPVHLSALFTPHLMKQP-EAAIVQVTSGLAFNPLAVYPVYCATKAALHSFSLTLRHHVRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTY----------------RGISSEEYVQYFLDGLKEGKQEITNE............... 227
10 -49.400[Q] KOG1210 Predicted 3-ketosphinganine reductase  ali follow..  24  32.GAHVVVTGGSSGIGKCIAIECYKQGAFITL--VARNEDKLLQAKKEIDKQVVLCISVDVSDYNQVENVIKQAQEKLGPVDMLVNCAGM-----AVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERR-VGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLET---------RLISETTSVCKPEQVAKQIVKDAIQGNFNSSLG............... 268
11 -49.000[R] KOG1611 Predicted short chain-type dehydrogenase  ali follow..  20  4..KSVVVTGSNRGLGFGLVQQFLKDPNVQHVIATARDVDKATALK-GICDPRLHILQLSLGSDESIANFAEKVSEIVGELTLLINNAAVMLP----YVTKQKPDRKVVLDLFESNTIGPMMLTQSLVPLIIKASKGAIINIASEFLGSISENTSGAYRMTKCAVNQFTKTLSIDLKDDHILTAGICPGMVQTDMSKG------------------------KGQLTIEESSSQILAAFNKLGAT--NGGYFRRDLSII..... 249
12 -49.000[Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11  ali follow..  16  52.GEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGEDTVKQIQDIYKVRAKAYKANVTNYDDLVELNSKVVEEMGPVTVLVNNAGVM-----MHRNMFNPDPADVQLMINVNLTSHFWTKLVFLPKMKELR-KGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELNQKDIHVTTVLPSFLRTNSDVTQLTHT-------------IGFGDVYPLFTGEEVAQRIVAGMVRGEAEITVPGMACL.......... 288
13 -48.700[IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases  ali follow..  19  5.GKNVVYLGGFGGIGQKCVQELLQRPIKLAIFDLNANEQLLAKWKSQHPDTDVFYHKLDITQKSDIDAAYKATAERFGHFDVVVNGSGLM-------------NDRLVELTIQINLLGVINSTLTALEYMDKAKGGGLIVNISSVAGLQPTAIMAIYSAAKTGVTTFTRAMANPYAHSGVGFLTICPGFTDTGLLEDIGNK-----TTFTYDTPMLAMFNRVKRQKAEDCARNLVSAIETSKNGTV................. 236
14 -48.600[Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases  ali follow..  21  7.SPVVLITGCSQGIGHALAREFTEKGCRVV--ATSRSRSTMTDLEQD---SRLFVKELDVQSDQNVSKVLSEVIDKFGKIDVLVNNAGV-----QCVGPLAETPISAMENTFNTNVFGSMRMTQAVVPHMVSKK-KGKIVNVGSITVMAPGPWAGVYTATKAAIHALTDTLRLELRPFGIDVINVVPGGIRTNIANSAVATFNKMPELKEAIRERAFISQRMNPTPAETFARDTVAAVLKKNPP................... 265
15 -48.600[Q] KOG1205 Predicted dehydrogenase  ali follow..  21  47.GKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRQVVADRCRKLGSPDVAVVRGDVSVIKDCKRFVQETISRFGRLDHLVNNAGI----AEAKFFEDYSEISDVLPIVNTNFWGPVYATHFAIPHLKKTK--GKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIELHP-EVGVTIVFPGLIENGNTNP--------DLLAESLLQKQDWSQVVTIESAAECAKAVVNGICRGKTFVAEP............... 279
16 -46.200[I] KOG1478 3-keto sterol reductase  ali follow..  23  1MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLL--MPAILLLRFFANAFTLTPYNGTEALVWLFHQKPE.................... 277
17 -42.800[Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  21  46.GLVAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKVRQGCDATRLHFIECDLTDFESVRRAAKETLESTDTIDILINNAGI------MFQSKHEQTKDGHEKTWQSNHLGPFLLTELFLPAVKKSS-YARIINVSSRIDKKSFGMMKSYRQSKLANVMHARALTKELRKDGVTVNSLHPGVVNTELARNT-------ILNTPGIKQITAVFRWFLMKTSRDGAQTSIFLALGKKIGGISGKYFA........... 301
18 -42.600[QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases  ali follow..  19  29.DKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAE---QLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGGLWGLVNNAGILTPITLCE-----LNTEDSMNMLKVNLIGVIQVTLSMLPLVRRAR--GRIVNVSSILGRVA-FFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFTNLNLVTDCMEHALTSVHPRYSAG............... 284
19 -41.800[I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3  ali follow..  25  47MGQWAVITGAGDGIGKAYSFELAKRGLNVVL--ISRTLEKLEAIATEIERTSVKIIQADFTKDDIYEHIKEKLAG---EIGILVNNVGMLPNL----PSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQ-KGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTN.............................................................. 242
20 -37.900[S] COG3007 Uncharacterized paraquat-inducible protein B  ali follow..  13  41.PKRVLVIGASTGYGLAARITAAGCGADTLGVFFERPGEEGKHKFAAQKGLYAKSINGDAFSDEIKQLTIDAIKQDLGQVDQVIYSLASPRRTHPKNSALKPIGNAVNLRGLDTDKEVIKESIDSTVAVMGGEAEGAQTTAFTYLGEKITHDIYGSIGAAKKDLDQKVLAIRESLAAHGGDARVSVLKAVVTQASSAI---------PMMPLYLSLLFKVMKEKGTHEGCIEQVYSLY----KDSLCGDSPHMDQE....... 327
21 -36.600[I] COG4982 3-oxoacyl-[acyl-carrier protein] reductase  ali follow..  14  358.SEIAVVTGASKGIAASVAARLLDGGATVIATTSKLDEERITFYRAARYGAALWVVAANMASYSDIDALVEWIGNEAQTPTLLFPFAAPRV-----IGDLSEAG-ARSEIEMKVLLWAVQRLIVGLSKIGTERDVASRLHVVLPGSPNRGFGGDGAYGEAKSALDAVVSRWHAESWAARVSLAHALIGWTRGTGLMGHNDVIVSAVEE-----------AGVTTYSTDEMAAMLLDLC-NAESKVAAAGTVDLTGGL...... 620
22 -20.200[M] COG1089 GDP-D-mannose dehydratase  ali follow..  14  1MTKVALITGVTGQDGSYLAEFLLDKGYEVHGIKRRASSFNTERIDHHGSNPNFHLHYGDLTDSSNLTRILKEV-----QPDEVYNLAA---------MSHVAVSFESPEYTADVDAIGTLRLLEAIRFLGLENK---RFYQASTSEESTPFYPRSPYAVAKLYAYWITVNYRESYGIYACNGNHESPRRGETFVTRKITRGLANIAQGLESCLYLGNMDSLRDWGHAKDYVRMQWLMLQQEQPEDFTGVQYSVRQ........ 261
23 -18.700[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  13  34LPPLVTVFGGSGFVGRHVVRMLAKRGYRIRV--AVRRPDLAGFLQPLGNVGQISFAQANLRYRDSIIKAVE-------DADHVVNCVGILAESGR-------------NTFDAVQEFGAKAIAEAA------RDTGATLTHISAIGADANSQ--TGYGRTKGRAEAAIH-------SVLPGAVILRPSII-----------FGPEDDFFNKFAKMARNLPFKTKFQPVYVEDVAEAVARSVDGKLKPGAIYELGGPDVMTFR. 254
24 -18.500[IE] KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases  ali follow..  16  6.GEVLLVTGGSGFLGQHLIKQLLERKEELGIKEIRSLDIV-NNIGHEETSLLRTYVADIGGDLKALSPIFN-------GVDGVFHCAASVKIEYP----------PNYEELERVNVNGTLAVVDLCI-----QNNVKRLVYTSCTSVCFVPFKIPGYASSKLRAENIVLNSPLHNQKEYLATSAMRAGECDSHFITEIFDFLSTRGWVFPRIAGVGGKQQLVYAGNVAW-GHICAYKALKVSDKAVNGLPVFVTDD....... 280
25 -17.600[C] KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit  ali follow..  15  67SGIVATVFGATGFLGRYLVQQLAKMGSQVLVP-FRGSEDSPRHLKLMGDLGQVVPMKFDPRDEDSIKAVMAKA-------NVVINLIGREYETRN-------------FSFEDANHHIAEKLALVC-----EHGGIMRYIQVSCLGASVSSP--SRMLRAKAAAEEAVL-------NALPEATIMRPATM---------------GTEDRILNPWSMFVKKGTTKYPVDVAAAIVAALKDDGSS--MGKTYELGGPDVFTTH. 289
26 -16.600[M] COG1088 dTDP-D-glucose 4,6-dehydratase  ali follow..  17  2..RKILITGGAGFIGSALVRYIINETSAVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDICDRAELARVFTE------QPDCVMHLAA---------ESHVDRSIDGPAAFIETNIVGTYTLLEAARAYTEDKKSAFRFHHISTDEETTPYAPSSPYSASKASSDHLVRAWLRTYGLPTLITNNYGP----YHFPEKLIPLMILNALAGKPLPVYGNGQQIRDWLYVEDHARALYCVATTGK----VGETYNIGGH....... 254
27 -16.500[G] KOG0747 Putative NAD+-dependent epimerases  ali follow..  16  6.PKNILITGAAGFIASHVANRLIRSDYKIVVLDKLDYCSNLKNLNPSKHSPNFKFVKGDIASADLVNHLLIT------GIDTIMHFAA---------QTHVDNSFGNSFEFTKNNIYGTHVLLEAC----KVTGQIRRFIHVSTDEVYGETDE-NPYSATKAGAEMLVMAYGRSYG--PVITTRGNNVYGPNQFPEKLIPKFILLAMRGQVLPIHGDGSNVRSYLYCEDVAEAFEVVLHKGE----VGHVYNIGTK....... 253
28 -15.300[V] KOG1502 Flavonol reductase/cinnamoyl-CoA reductase  ali follow..  16  7.GKVVCVTGASGYIASWLVKFLLSRGYTVSVRDPSDPKKTQHLVSLEGAKERLHLFKADLLEQGSFDSAID-------GCHGVFHTA----------SPFFNDAKDPQAELIDPAVKGTLNVLNSC----AKASSVKRVVVTSSMAAVGYNASKMWYVLSKT----LAEDAAWKLAKEGLDIVTINPAMVIGPLLQPTLNTSAAAILNLINGAKTFPNLSFG-WVNVKDVANAHIQAFEVPSAN---GRYCLVER........ 256
29 -15.200[R] KOG4288 Predicted oxidoreductase  ali follow..  13  3....IVVLGGSGFLGHNICKLAIAKGYEVVS--VSRRGAGGLHNKEPWMDDVEWETLDAQKDPNSLLPVLRDA-------SAVVNSVGILMENNYKKKPEEAKQSKNKVTFEAINRDLAIETAKIA-----AKANVPVYCYVSAHAAAPGLD--PRYIKTKREAEREISKIS------NLRSIFLRPGFMYNFNDRPFTGALASLFTVSSSINRATSGALNFEPLPSEEVALAALEAISDPSVKGP................. 258
30 -14.600[MG] COG0451 Nucleoside-diphosphate-sugar epimerases  ali follow..  14  3....YLVTGTAGFIGFYVAKRLLDAGHFVTGFD-YDVSLKEKRHAILARSNGFRAEIGMLEDTDALKRAAEAA-----EPEIIIHLAAQAGVRYSLENPRAY---------IDSNLIGSFNMLELA-----RSLKVKHLMLASTSSSDKADEPMTLYAATKKSMELMAHSYAHLH---KLPTTAFRFFTV-------------------------------GPWGRPDMAPIKFVDAVSNGQPIDIYG-----QGNMSRDF.. 218
31 -13.700[M] COG1087 UDP-glucose 4-epimerase  ali follow..  19  3....ILVTGGAGYIGSHTCVQLIEAGHEVVVVDFDNSHPEALHRIEKITGRAPRREPGDIRDRALMEQMIKR------KCTAVIHFAGLKAVGESSEKPL---------LYYDCNVLGTLRLLQAM-----EATGVKKLVFSSSATEDQPLSATNPYGRTKLVIEDMLRDLYNSDNSWAIAI................................................................................. 173
32 -13.300[M] KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase  ali follow..  11  95..THVLVTGGAGYIGSHAALRLLRDSYRVTIVDRGNLGAVKTLQQLFPQTGRLQFIYADLGDPLAVEKIFSE------AFDAVMHFAAVAYVGESTLYPL---------KYYHNITSNTLGVLEAMARHKVKK------LIYSSTCATYGEPEINPYGKAKKMAEDMILDFSKNSDMAVMILRYFNV............................................................................ 274
33 -12.900[GM] KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase  ali follow..  15  30.NMRILVTGGAGFIGSHLVDKLMQNEKNEVIVADNYFTGSKDNLKKWIGHPRFELIRHDVTE------------PLFVEVDQIYHLACPASPIFYKYNPV---------KTIKTNVIGTLNMLGLA------KRVGARILLTSTSENVNPIGVRSCYDEGKRVAETLMFDYHRQH---GIEIRIAR-GPRMNIDDGRVVSNFIAQALRGEALTVQKPGTQTRSFCYVSDMVEGLMRLMEGDQTGPIN................ 265
34 -12.500[GO] KOG1431 GDP-L-fucose synthetase  ali follow..  13  7.SMRILVTGGSGLVGKAIQKVVADGAGLPGEDWVFVSSKD-----------------ADLTDTAQTRALFEKV-----QPTHVIHLAAMVGGL--------FRNIKYNLDFWRKNVHMNDNVLHSA-----FEVGARKVVSCLSTCIFPPHNSNFGYSYAKRMIDVQNRAYFQQYGCTFTAVNVFGPH--DGHVLPGLIHKVHLAKSSGSALTVWGTGNPRRQFIYSLDLAQLFIWVLREYNE--VEPIILSVGEEDEVSIK. 253
35 -11.700[R] COG1090 Predicted nucleoside-diphosphate sugar epimerase  ali follow..  16  35....IILTGATGFVGCSLVPLLHQQGHELTL--LVRSVSKAQRLFAPGSFPQLKAIAYEATKSGDWQKVVD-------GQDAVINLAG-------------EPISERWTEAYKAEIFSRKLGTEKLVEAIAKADRKPQVMISGSAIGYYGTSETATFTESSKPGDDFLAEVAHQVEQLGVRLVVFRIGIV......................................................................... 206
36 -11.700[Q] COG3321 Polyketide synthase modules and related proteins  ali follow..  14 1764...SYIITGGLGGLGLFFASKLAEAGCGIVLTARSQPNPKARQTIERLCGADIVVECGNIAEPYTADRLVNAATATGLPLRGVLHSAAVVED-----ATLTNITDELIDRDWSPKVYGSWN-----LHCATIGQPLDWFCLFSSGAALLGSPGQGAYAAANSWVD----LFAHWRRAQGLPVSAIAWGA-EVGRATFLAEGGEIMITPDEGAYAFEMLVRYDR........................................ 1973
37 -11.600[Q] COG3320 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes  ali follow..  14  9..RTVLLTGATGFLGRYLALKWLER-VEGKVIALVRAKSNEDARARELATDHLEVIAGDKGEVD---ELDRQTWRRLADVDLIVDPAALVN-------------VLPYSELFGPNTLGTAELIRIALTSKQKPYIYVSTIGVGNQIEPAKFTE-NGYGNSKWAGEVLLREAH---DLCGLPVTVFRCDMILAD-----TSYAGQLNVPDMFTRMMLSLAATGDGLPVEFIAEAISTLGDQSLHDRDGFTTYHV.......... 294
38 -10.900[T] KOG4039 Serine/threonine kinase TIP30/CC3  ali follow..  15  240KMSSAFVVGATGAVGSELVKLLAESTKFSKVVVLARRPVDGAT------GDKLIQKTVDFDKLEENAEDIQGVDVAFCALGTTRGKSG--------------------DGFYKVDHDYVMSAAKMA-----KENGVKQFVLVSSVGA--DASSRFLYPKTKGEVEKEIGELNFE------KFVIMRPGLIEAK-----RPEFRIGEFLGKIVTAPLGLFSNRFSSSATAIAQAMINATQTEETG................... 440
39 -10.500[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  14  644.GQYFLLTGATGYFGRRFLEYLVKLNISVVCLVRESSDEAAKERLISISSENIIVWAAHVEDDAKWEFLVE-------NVSRIYHMAAEVH-------------MKSYQELRPANVLGTKTVLELS------VMGPKALYFISGGGQQEVELD-SGYALSK-----VAELLCRKISDLGHLIYVIRPGFISRDFFWRFVATALRMGIWPQSDESQSLVFH---ISTTDALCMTLTQILEKEADA................... 882
40 -10.300[MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases  ali follow..  20  281.EKSVMVTGAGGSIGSELCRQILAQKPKTLVL-FELNEYNLYTIDQELQAIKIVAALGSVQRENRVKKLMQAHQVE------TVYHAAAYKHVPLVEDNVIE--------GIRNNVFGTLACANAAIEA-----GVKNFTLISTDKAVRPT---NIMGASKRMAELVLQALADKNSTTIFTMVRFSSGSVVPLFKKQIRAGGPVTVTHPDIIRYFMLI--------PE-----AAQLVIQAGAMSHNGQVFVLDMGEPVKI.. 517
41 -10.300[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  12  1MKKNVLIIGAGG-VAQVVAHKCAQNSGDIHIASRTVDKESVREKKSLKTEVKLEAHALDALDVEATKALIVST-----GSQIVINVGS------------AFVNMSVLRACMDTGV---------------------AYMDTAIHEEPNKICETPPWYGNY------EWKRAAECKEKGITAIGFDPGVVNA....................................................................... 158
42 -10.000[M] COG1091 dTDP-4-dehydrorhamnose reductase  ali follow..  14  3....LAVTGRNGQVVSALQALAGADLE---IVTLGRPE-------------------LDLVRPENVLQALREA-----KPDVVVSAAAYTA---------VDKAESEPDIAFAVNRDGAKAVAQAA------KELGVPVIHLSTDYVFDGSKATSIYGRSKLK------------GERAVSEATDNYVVLRTAWVYSEYGNNFVKTMLKLSESRDEINVVADQFGCPTDIAAAVVAIAVEDSSASLRGIFHLSGTGETTWAN. 223
43 -9.770[G] KOG1203 Predicted dehydrogenase  ali follow..  18  123..GIILVAGATGGVGRRIVDILRKRGLPVKA--LVRNEEKARKML----GPEIDLIVADITKENTL------VPEKFKGVRKVINAVSV.............................................................................................................................................................................. 197
44 -9.620[I] KOG1221 Acyl-CoA reductase  ali follow..  15  21.NKTILITGATGFMGKVLVEKLLRS-NVIYLLIRTKKGVDPSVRKEQY--DKVRVVKGDLLSANDTNTLAS-------NVEVVFHCAANVR-------------DQPLRPMVMMNVVG----TLKVLRLAEKMSQLQALVHVSTSYCQCNES--NTYAYSKA----LSEDLICRYNN-KLPIIITRPSIVTAAIHEPL................................................................. 251
45 -9.170[Q] COG5310 Homospermidine synthase  ali follow..  9  16ITGPVVMIGFG-SIGRGTLPLIERHFSRMTVLDPRDTDRKLLDER----GIAFVQEAVTENN---YKKLLTPLLTNGGGQGFCVNSVDLMRLCRKLGVLYIDTVVEPWLGFYFDAKADNASRTNYALREAMIKEKHDKPGGATVVSTCGANPGMVSWFVKQAL.................................................................................................... 180
46 -9.130[S] COG3268 Uncharacterized conserved protein  ali follow..  12  10....IVLYGATGFSGKLTAEHLALSESTARIALAGRSSERLRNVRALLGAQDWPLIVADASQPSTLEAMAGRA-------QVVLTTVG---PYTRYGLPLVAACARTGTDYADLT--ELMFCRNSIDLHHKQAAATGARIILACGFDSVPSDLNVYQLYRRVIEDRTGELCDTDLVLRSFSQRWVSGGSVAA....................................................................... 188
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.