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Query: [Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDGADAEEHGGFLFFVLASSVVFIVLFFTRRYFKGGQFNERVSAKGLVAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKRMLVRQGCDATRLHFIECDLTDFESVRRAAKETLESTDTIDILINNAGIMFQSKHEQTKDGHEKTWQSNHLGPFLLTELFLPAVKKSSYARIINVSSRIHLKSEKINLATVDDKKSFGMMKSYRQSKLANVMHARALTKELRKDGAEHVTVNSLHPGVVNTELARNTILNTPGIKQITAVFRWFLMKTSRDGAQTSIFLALGKKIGGISGKYFADCKLTQENPLALDDQACQDLYNYSLECTGLAKLast
1 -109.000[Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali  100  1MDGADAEEHGGFLFFVLASSVVFIVLFFTRRYFKGGQFNERVSAKGLVAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKRMLVRQGCDATRLHFIECDLTDFESVRRAAKETLESTDTIDILINNAGIMFQSKHEQTKDGHEKTWQSNHLGPFLLTELFLPAVKKSSYARIINVSSRIHLKSEKINLATVDDKKSFGMMKSYRQSKLANVMHARALTKELRKDGAEHVTVNSLHPGVVNTELARNTILNTPGIKQITAVFRWFLMKTSRDGAQTSIFLALGKKIGGISGKYFADCKLTQENPLALDDQACQDLYNYSLECTGLAK 333
2 -72.600[I] KOG1478 3-keto sterol reductase  ali follow..  22  3..............................................KVVLITGASSGIGLALCKRLLAEDLHLCLACRNMSKAEAVCAALLASHPT-AEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDPSQLIWTSSRSARKS-NFSLEDFQHSKGK---EPYSSSKYATDLLSVALNRNFNQQG---LYSNVACPGTALTNLTYGILPPLMPAILLLRFFANAFTLTPYNGTEALVWLFHKPESLNPLIKYLSATNYIMTQKMDLDEDTAEKFYQKLLELEK... 321
3 -42.800[Q] KOG1204 Predicted dehydrogenase  ali follow..  21  2.............................................GKVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQS---LQREYGADKFVYRVLDITDRSRMEALVEEIRQKHGKLDGIVANAGMISQSNSEHDIKQWERLFDVNFFSIVSLVALCLPLLKSSPVGNIVFVSSGA-------------SVKPYNGWSAYGCSKAALNHFAMDIASEEPSDK---VRAVCIAPGVVDTQMQKDIGMTPKALERFTQLYKTSSLLDPKVPAAVLAQLVLKGIPDSLNGQYLR................................ 252
4 -42.200[R] COG4221 Short-chain alcohol dehydrogenase of unknown specificity  ali follow..  23  4..........................................SLQGKIAVITGAASGIGLATTEALLEQGATVVMVDWNEKALNDLAAKL------GERAIPQVTNLLDADSCNAMIPEILGKVDHIDILYCNAGTYIGGDLETTPEAIDKMLNLNVNAVMKNVQAVVPHMSERKTGDIIVTCSIAGHFP-------------TYWEPVYSGSKWAITSFVQGMRRQMIPHG---VRVAQVSPGPVVSALLADWPEENLRKAKESGSLI-----DASEVADAVVYMLTRKR.......................................... 226
5 -40.400[R] COG0300 Short-chain dehydrogenases of various substrate specificities  ali follow..  20  1...........................................MRKKTIFITGASSGLGRQLAIDFSWEETVLCLFARSQERLENVQRIVVEN---GGEAHIYPVDLADPQSIDRSFAEAISAVGVVDVLINNAGYGVFEPFCDSQDENERMFRVNVFGLMRATAAVLPTMREQGSGHIINIASQAGKIA-------------TAKSAIYSATKHAVLGFTNSLRMELKGTG---IHVSAVNPGPIQTPFFDQADKEGAYTSKVQRIML-----DPEDVSEKIVQLTKKPKRELNLP.................................... 231
6 -39.800[R] KOG1611 Predicted short chain-type dehydrogenase  ali follow..  23  1...........................................MSPKSVVVTGSNRGLGFGLVQQFLKDPNHVIATARDVDKATALKG-------CDPRLHILQLSLGSDESIANFAEKVSEIESGLTLLINNAAVMLPYVTKPDRKVVLDLFESNTIGPMMLTQSLVPLIIKASKAIINIASEFL-------SISENTSGSGEYKAMAYRMTKCAVNQFTKTLSIDLKDDH---ILTAGICPGMVQTDMSKGKGQ-----------------LTIEESSSQILAAFNKLGATH-NGGYFR................................ 243
7 -39.400[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali follow..  22  1.........................................MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAEAKQQL-------PNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELFVEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLA-------------VYPVYCATKAALHSFSLTLRHHVRDTS---VEVIEMAPPMVDTGLNQKSRDKQGLTYRGI---------SSEEYVQYFLDGLKEGKQEITNE.................................... 227
8 -39.400[IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  23  3..........................................KLTGKTALITGASQGIGEGIARVFARHGANLILLDIS-DEIEKLADELGGR---GHRCTAVKADVRDFASVQAAVARAKETEGRIDILVNNAGVCRLGNFDMSEEDRDFHIDINIKGVWNVTKAVLPEMIKRKDGRIVMMSSVTGDMVAD------------PGETAYALSKAAIVGLTKSLAVEYAQSG---IRVNAICPGYVRTPMAESIARQSNVLTEMAKAIPLRRLADPLEVGELAAFLA-SDESSYLTGTQN................................. 247
9 -39.200[R] KOG0725 Reductases with broad range of substrate specificities  ali follow..  17  2..............................................SCALVIGATSTLGKAVVRRLAFTGYKVAAAADCPNSVGKVAEDNIKV---GGDVTAFSLDVANAEHRKELITKVAEKLGGLDTLIIVPPQVLGEIIETSGEDFDKLFANNLTTPFRLSQAAMSTLAKSQNGSIIYLTSCFGFTPSI-------------DMGLYSVASSSVLSLTKSVAQSAAKQG---VRVNSVVSGMIEGDGTGAVEEARQIKQHLESMIPLGRLGRPSDVASYVEFLA-STKARYITGENC................................. 243
10 -38.200[Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11  ali follow..  19  18...........LIGLAAITPLLILVALLGRLIAKLCWCSAPKSIAGEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDIYK--VRAKAYKANVTNYDDLVELNSKVVEEMGPVTVLVNNAGVMMHRNMNPDPADVQLMINVNLTSHFWTKLVFLPKMKELRKGFIVTISSLAGVFP-------------LPYSATYTTTKSGALAHMRTLRMELDLENQKDIHVTTVLPSFLRTNSDVTQLTHTIGFGDVYPLF------TGEEVAQRIVAGMVRGE.......................................... 277
11 -36.600[Q] KOG1210 Predicted 3-ketosphinganine reductase  ali follow..  19  1..............MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINKQVVLCISVDVSDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLG-------------LFGFTAYSASKFAIRGLAEALQMEVKPYN---VYITVAYPPDTDTPGFAEENRTKPLETRLISETTSVC--KPEQVAKQIVKDAIQGNFNSSLG.................................... 268
12 -36.400[I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase  ali follow..  23  73..........................................KVESPVVVITGASRGIGKAIALALGKAGCKVLVNARSAKEAEEVAKQIEEY---GGQAITFGGDVSKATDVDAMMKTALDKWGTIDVVVNNAGITRDTLLRMKQSQWDEVIALNLTGVFLCTQ-----------GRIINISSVVGLIGNI-------------GQANYAAAKGGVISFSKTAAREGASRN---INVNVVCPGFIASDMTAELGEDMEKKILGTIPLGRY---KAEEVAGLVEFLALSPAASYITGQAF................................. 300
13 -35.100[I] COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)  ali follow..  14  3..........................................FLSGKRILVTGVASSIAYGIAQAMHREGAELAFTYQN-DKLKGRVEEFAAQLGSD---IVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLAVTREGFKIAHDISSYSFVAMAKACRSMLNPG--SALLTLSY-------------LGAERAIPNYNVMGLAKASLEANVRYMANAMGPEG---VRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLC-SDLSAGISGE................................... 243
14 -34.900[Q] KOG1205 Predicted dehydrogenase  ali follow..  23  14............IVTVSFLLVFMPFSIFFKLLQFIRGCKESEKVNGKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKL--GSPDVAVVRGDVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSE-VLPIVNTNFWGPVYATHFAIPHLKKTK-GKIIAVASPAGWSG-------------VPRMSIYAASKAAMINFYETLRIELH----PEVGVTIVFPGLIENGNTNP................................................................................ 236
15 -34.200[QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases  ali follow..  24  26..........................................HLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQ------TSDRLETVTLDVTKMESIAAATQWVKEHDRGLWGLVNNAGILTPLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRAR-GRIVNVSSILGRVAFFV--------------GGYCVSKYGVEAFSDILRREIQHFG---VKISIVEPGYFRTGMTN................................................................................. 215
16 -33.500[Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases  ali follow..  23  6............................................ESPVVLITGCSQGIGHALAREFTEKGCRVVATSRSRSTMTDLEQD--------SRLFVKELDVQSDQNVSKVLSEVIDKFGKIDVLVNNAGVCVGPLAETPISAMENTFNTNVFGNMRMTQAVVPHMVSKKKGKIVNVGSITVMAP-------------GPWAGVYTATKAAIHALTDTLRLELRPFG---IDVINVVPGGIRTNIANS................................................................................ 212
17 -32.300[I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3  ali follow..  24  48.............................................GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTG--RSVKIIQADFTKDDIYEHIKEKLAG---EIGILVNNVGMLP---FLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPL-------------YSMYSASKAFVCAFSKALQEEYKAKE---VIIQVLTPYAVSTAMTKYLNTN-------------VITKTADEFVKESL................................................. 256
18 -29.800[IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases  ali follow..  22  2..........................................DLAGKNVVYLGGFGGIGQKCVQELLQRPIKALAIFDLNANEQLLAK--WKSQHPDTDVFYHKLDITQKSDIDAAYKATAERFGHFDVVVNGSGLM-------NDRLVELTIQINLLGVINSTLTALEYMDKAKGGKIVNISSVA---------------QPTAIMAIYSAAKTGVTTFTRAMANPYF--AHSGVGFLTICPGFTDTGLLEDI............................................................................... 193
19 -28.300[I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes  ali follow..  17  315......................................VKIKSLCNKVVVVTGAGGGLGKSHAIWFARYGAKVVV--NDIKDPFSVVEEINKLYG---EGTAIPDSHDVVTEAPLIIQTAISKFQRVDILVNNAGILRDKSFKMKDEEWFAVLKVHLFSTFSLSKAVWPIFTKQKSGFIINTTSTSGIYGN--------------GQANYAAAKAAILGFSKTIALEGAKRG---IIVNVIAPHAETA-----------MTKTIFSEKELSNHFDASQVSPLVVLLASEYSGRRVIGQLFE................................ 550
20 -22.400[I] COG4982 3-oxoacyl-[acyl-carrier protein] reductase  ali follow..  13  355..........................................LYSSEIAVVTGASKGIAASVAARLLDGGATVIATTKLDEERITFYRALYRDHARYAALWVVAANMASYSDIDALVEWIGNEQTEPTLLFPFAAPRVIGDLSEAGARSEIEMKVLLWAVQRLIVGLSKIGTERDASRLHVVLPGSPNRGM------------FGGDGAYGEAKSALDAVVSRWHAES--SWAARVSLAHALIGWTRTGLMGHNDVIVSAVEEAGVTTY-----STDEMAAMLLDLC-NAESKVAAAG................................... 609
21 -20.200[S] COG3007 Uncharacterized paraquat-inducible protein B  ali follow..  10  24............................VKKQIDYVTTEGPIANGPKRVLVIGASTGYGLAARITAAFGGADTLGVFFERPGEEGKPGTSKFAAQKGLYAKSINGDAFSDEIKQLTIDAIKQDLGQVDQVIYSLAIKESVLQPATQSEIDSTVAVGGEDWQMWIDALLDAGVLAEGAQTTAFTYLGEKITHDI------------WNGSIGAAKKDLDQKVLAIRESLAAH--GGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKEK---THEGCIEQVYSLYLCGDSPHMDQEGRLRADYKELDPEV--QNQVQQLWD.......... 350
22 -15.200[IE] KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases  ali follow..  12  3..........................................NKSGEVLLVTGGSGFLGQHLIKQLLERKEELGIKEIRSLDIVPYKNNIGHEE-TSLLRTYVADIGGDLKALSPIFNG-------VDGVFHCAASVKI-----YPPNYEELERVNVNG----TLAVVDLCIQNNVKRLVYTSCTSKTDTPTLDSSTLWEQDNQFLIPGYASSKLRAENIVLNSNGAPLHNQKEYLATSAMRAPLT-TEIFDFLSTRGWVFPRIAGVGGKQQLVYAGNVAWGHICAYLKVSDKAVNGLPV................................. 275
23 -14.800[C] KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit  ali follow..  18  64.........................................SSVSGIVATVFGATGFLGRYLVQQLAKMGSQVLVPFRGSEDS----PRHLKLMGDLGQVVPMKFDPRDEDSIKAVMAK-------ANVVINLIGREYETRNFSFED------------NHHIAEKLALVCEHGGIMRYIQVSCLG---------------ASVSSPSRMLRAKAAAEEAVLN----------ALPEATIMRPATM....................................................................................... 221
24 -14.400[M] COG1089 GDP-D-mannose dehydratase  ali follow..  17  2.............................................TKVALITGVTGQDGSYLAEFLLDKGYEVHGIKRSSFNTERIDHIYQDPHGSNPNFHLHYGDLTDSSNLTRILKEV-----QPDEVYNLAAMSHVAV---SFESPEYTADVDAIG----TLRLLEAIRFENKTRFYQASTSE----GLVQEIPQKESTPFYPRSPYAVAKLYAYWITVNYRESYGIYACNGILFNHESP.......................................................................................... 190
25 -13.500[R] KOG4288 Predicted oxidoreductase  ali follow..  9  3................................................IVVLGGSGFLGHNICKLAIAKGYEVVSVSRRGAGGLHNKEP-------MDDVEWETLDAQK-------PNSLLPVLRDASAVVNSVGIL-------MENNYKKILQNPRGPVSHLINSLSSNMFKTGQNPLAPKPEEAKQSKNKVTFEAINRDLAIETAKIYIKTKREAEREISKIS---------NLRSIFLRPGFMYNFNDRPFTGALASLFTVSSSINRATSGALNFLGTASAEPLPSEEVALAALEAISDPSVKGPVEISELKSMAHKFKQKS........ 275
26 -13.500[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  16  31.........................................LANLPPLVTVFGGSGFVGRHVVRMLAKRGYRIRVAVRRPDLAGF-----LQPLGNVGQISFAQANLRYRDSIIKAVED-------ADHVVNCVGIL----AESGRNTFDAV-------QEFGAKAIAEAARDTG-ATLTHISAIG---------------ADANSQTGYGRTKGRAEAAIHS----------VLPGAVILRPSII....................................................................................... 186
27 -13.400[M] KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase  ali follow..  14  95..............................................THVLVTGGAGYIGSHAALRLLRDSYRVTIVDNLSRGNLGAVKTLQQLFPQTGRLQFIYADLGDPLAVEKIFSE-----NAFDAVMHFAAVAYVGE---STLYPLKYYHNITSN----TLGVLEAMARHKVKKLIYSSTCA----GEPEKMPITEDTPQVPINPYGKAKKMDMILDFSKNSDMAVMILRYFNVIGSDPGRLGEAPRPELREQGRISGACFDAARGFIPGKTSDGTCIRDYIDVTDACKKATGV-FLPRRPGDYAEVYSDPTKILKDLNWTARFTNLQD 417
28 -13.300[V] KOG1502 Flavonol reductase/cinnamoyl-CoA reductase  ali follow..  18  6............................................EGKVVCVTGASGYIASWLVKFLLSRGYTVKASVRDPSDPKKT-QHLVSLEGAKERLHLFKADLLEQGSFDSAIDG-------CHGVFHTASPFFNDAKDPQAELIDPAVK--------TLNVLNSCAKASSVKRVVVTSSMADVTVDETWFSDPELCE--ASKMWYVLSKTLAEDAAWKLAKE------KGLDIVTINPAMVGPLLQPTLNTSAAAILNLIN--LSFGWVNVKDVANAHIQAFEVPSA---NGRYC................................. 252
29 -12.600[MG] COG0451 Nucleoside-diphosphate-sugar epimerases  ali follow..  15  3................................................YLVTGTAGFIGFYVAKRLLDAGHFVTGF--TKYYDVSLKEKRHAILARSNGFRAEIGMLEDTDALKRAAEA-----AEPEIIIHLAAQAGVRY---SLENPRAYIDSNLIG----SFNMLELARSLKVKHLMLASTSS--YGANEKIPFAESDKADEPMTLYAATKKSMELMAHSYAHKLPTTAFRFFTVYG-RPDMAPIKFVDAVSNGQPIDIY--------------QGNMSRDFTYIDDLVEGI...................................... 228
30 -11.600[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  12  3..............................................KNVLIIGAGG-VAQVVAHKCAQNSGDIHIASRTVDKCRKIVESVREKKSTEVKLEAHALDALDVEATKALIVS-----TGSQIVINVGS---------------------FVNMSVLRACM------DTGVAYMDTAIHEEPNKICETPPWYGNY-------------------EWKRAAECKEKGITAILGVGFDPGVVNA..................................................................................... 158
31 -11.500[M] COG1087 UDP-glucose 4-epimerase  ali follow..  14  3................................................ILVTGGAGYIGSHTCVQLIEAGHEVVVVDNFDNSHPEALHRIEKITGR--APRREPGDIRDRALMEQMIKR-----HKCTAVIHFAGLKAVGE---SSEKPLLYYDCNVLG----TLRLLQAMEATGVKKLVFSSSAT----GDPDKLPITEDQPLSATNPYGRTKLVIEDMLRDLYRYFNPVGAHESGLIGEDPKGIPNNLMPIIAQVATGRREKLNIWGNDYPTPDGTGVRDYIHVNDLAAGHLKALKKLDKPKCFAVNLGTGQGYSVLDVIKAFEHVSNRE. 281
32 -11.200[M] COG1088 dTDP-D-glucose 4,6-dehydratase  ali follow..  15  2..............................................RKILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMS--LAPVAQSERFAFEKVDICDRAELARVFTE-----HQPDCVMHLAAESHVDR---SIDGPAAFIETNIVG----TYTLLEAARAKSAFRFHHISTDEVYGDLHSTDDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLPTLITNCSNNYGP------------------YHFPEKLIPLMILNALAGKPLPVY................................................ 217
33 -10.700[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  14  643............................................NGQYFLLTGATGYFGRRFLEYLVKLNISVVCLVRESSDEERLISLVPSLRISSENIIVWAAHVEE-IRFGLDDAKWEFLVENVSRIYHMAAEVH--------KSYQELRPANVLG----TKTVL-ELSVMGPKALYFISGGG------QQEVELDDDTQSAKASGYALSKYV----AELLCRKISDLGHPLIYV--IRPGFIIAN.................................................................................... 826
34 -10.600[G] KOG0747 Putative NAD+-dependent epimerases  ali follow..  14  2.........................................ASYTPKNILITGAAGFIASHVANRLIRSYPDYKIVVLDKLDYCSNLKNL-NPSKHSPNFKFVKGDIASADLVNHLLIT-----EGIDTIMHFAAQTHVDN---SFGNSFEFTKNNIYG----THVLLEACKVTGQRRFIHVSTEVYGETDEDALVGNHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNNVYGPNQFPEKLIPKF---------ILLAMRGQVLPIHGDGSNVRSYLYCEDVAEAFVGHVYNIGTKKERRVNDVAKDICKLF............ 269
35 -10.600[R] COG2910 Putative NADH-flavin reductase  ali follow..  19  4................................................IALIGASGNAGSRILKELSDRGHQVTAIARNPEKIAA-----------LPNVVAKKGDVFDQAALSELLKGH-------DAVISSVHFTASD-----------------------PATLIEAVRASGVQRYLVVGGAG................................................................................................................................................... 100
36 -10.300[I] KOG1221 Acyl-CoA reductase  ali follow..  13  20............................................ANKTILITGATGFMGKVLVEKLLRS-NVIYLLIRT-KKGVDPSVRKEQYFKCVDKVRVVKGDLLE-PDLGLSANDTNTLASNVEVVFHCAANV------RFDQPLRPMVMMNVVG----TLKVLRLAEKMSQLQALVHVSTSYCQCNESVLEEQNPFSIIEMVETMDDEALAEIAYSKALSEDLICRYNNKLPIIITRPSIVTAAIHEPLPGWIEGVNGPTGLMI-----GAARGVIRSMHCNPDYASTVIPVDKAINGMILCGYQRGKASQEKGN............. 312
37 -10.200[G] KOG1203 Predicted dehydrogenase  ali follow..  25  123..............................................GIILVAGATGGVGRRIVDILRKRGLPVKALVRNEEKARKML---------GPEIDLIVADITKENTL------VPEKFKGVRKVINAVSVIVGPKEGDTPE.......................................................................................................................................................................................... 208
38 -9.970[Q] COG3320 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes  ali follow..  15  9..............................................RTVLLTGATGFLGRYLALKWLEREGKVIALVRAKSN-EDARARLDKTFDSTDHLEVIAGDKGE-VDLELDRQTWRRLADTVDLIVDPAALVN----------YSELFGPNTLG----TAELIRIALTSKQKPYIYVSTIG-TEDSDIRVISPTRNINNNYANGYGNSKWAGEVLLREAHDL------CGLPVTVFRCDMILADTSYAGQLNVP-------MFTRMMLSLAATGIAPGSFYELDAESNRQRAHYFIAEAISTLGDQSLHDRDGFTTYHVM........ 295
39 -9.450[Q] COG5310 Homospermidine synthase  ali follow..  11  1............................MLDKMANENWPVYGEITGPVVMI-GFG-SIGRGTLPLIERHFSRMTVLDPRDTDRKLLDER-------GIAFVQEAVTENNYKKL---LTPLLTNGGGQGFCVNLSV--------------------------TGSVDLMRLCRKLG-VLYIDTVVEPWLGFYFDAKADNASRTNYALREAM------------IKEKHDKPGGATVVSTCGANPGMVSW..................................................................................... 174
40 -9.440[S] KOG2733 Uncharacterized membrane protein  ali follow..  17  8................................................VIIFGASGFTGKYTVFEAVTRGLRWGIAGRNREKLEAVLKEMGAKAKDLSQVPIFIADVNDQASLLEMAKKCR-------IVVNTAGPYRFHGENVVKCCIES--GTHHVGEPQYMETMQLRYDQLAREKGVYVVSAC-------GFDSI--------------ADMGVVFVEKNFDGVVN........................................................................................................ 165
41 -9.220[MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases  ali follow..  15  279...........................................ITEKSVMVTGAGGSIGSELCRQILAQKKTLVLFELNEYNLYTIDQELQAIKQNLKLNTKIVAALGSVQRENRVKKLMQA---QVETVYHAAAYKHVP---LVEDNVIEGIRNNVFG----TLACANAAIEAGVKNFTLISTDTNIMGASKRMAELQALADKNSTTIFTMVRFGNVLGSS-FKKQIRAGGPVTVT----HPDIIR------------------------YFMLIPEAAQLVIQAGA-----SHNGQVF-----------VLDMGEPVKIVDLAKRMIHLM. 528
42 -9.110[R] COG1090 Predicted nucleoside-diphosphate sugar epimerase  ali follow..  15  33..............................................MKIILTGATGFVGCSLVPLLHQQGHELTLLVRSVSKAQRLFAP-----GSFPQLKAIAYEATKSGDWQKVVDG-------QDAVINLAGEPISERWTEAYKAEIFDSRKL------GTEKLVEAIAKADRKPQVMISGSA------IGYYGTSETATFTESSKPGDDFLAEV--CQAWENAAHQVEQLGVRLVVFRIGIV-------LGADGGALAKMLPPFKLFAGGPLGSGEQWFSWIDRRDLIALIDKALTDSTLRGTYNATAPNPVKMKEFCHTLGKVLA... 283
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.