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Query: [YU] KOG1241 Karyopherin (importin) beta 1, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTSDIAMQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKINTQVITQLast
1 -159.000[YU] KOG1241 Karyopherin (importin) beta 1  ali  100  1MTSDIAMQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKINTQVITQ 884
2 -119.000[U] COG5215 Karyopherin (importin) beta  ali follow..  31  1MSTAEFAQL--LENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRITQVSPEAKNQIKTNALTALVSIEPRIANAAQLIAAIADIELPHGAWPELMKIMVDNTGAEQPE-NVKRASLLALGYMCESADPQSQASSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQ----SYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEA---------TPSPIYNFYPALVDGLIGAANRIDNEF-NARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSS-VEPVADMLMGLFFRLLE--KKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDS-PVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDP-----QLYSEDATSRAAVGLIGDIAAMFPDGSIKFYGQDWVIDYIKRTRSGQLFATKDTARWAREQQKRQLS..... 860
3 -91.400[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  16  1MAQHELEQVIQLLQHAHSTDRDVQRNVQVQLVQLNEH--QKFCCYLVYILSKEMIDATSRSLAGLLLKNNIRAK-----------WNKYPQDVKFFVRTTCLKSIGDQEPLIRATVGIIVTTIVMEENMCDWPDLLDTLATVLMQPDEL--MQEGALGALQKVFEDSADRYESEFLRPIMPKLLVFY--EHHAAKMRALAMNCVNCILMVNNDPI--DFAIDQFLTSLFARHNDNDEEVQKQLCRSLTLLLDTHIEKMMPHLPNVIEYIIK-KTQDHNESIALEACEFWLSIAENSDICRTMVLPHLDKLIPVLLGSMRYSETDPALKANDEDSSVDEDDDDDGGGDWNIRRCSAASLDVLASIFGKDLLDKLFPLLKDTLMNDNWLVKESGILALGAIAEGCMDG-VVPHLGELIPFMLAMMFDKKPLVRSITCWTLSRYSSHIASDERQQFFKDVLANLLRCSLDGNKKVQEAACSAFATLEEEAGEQ-------------LIPFLGEILDQLVKAFQCYQAKNLLILYDAIGTLANSVGDA-LSHPVYVQMLMPPLMEKWERLSDED-------------KELFPLLECISAIVSAMGQSFLPYIQPVFTRCCSLIEKCVQQNETDFIIVALDLLSGLAESLPEHMDPLVANSKVELMLFCSLDVTPDVRQSCFALLGDLTKACPERVLPQSSNFIFFLAQNLDPSKI--SVCNNAIWALGELALKMGPAMKQFIGPIIEPLIVVINSQQNMQR--------TLLENTAITIGRLG----------QCCGEELAPHISRFVRPCCYSLRNIK-DNAEKESAFIGLCNMINMNPVGVLNDFIF--WCDAIASWT-VPTDSLRVLFAGILQSFKQQVGDFNWN 863
4 -61.000[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  10  373IAELRERKILRLLLKVKNGTPPMRKSALRQLTDQARDGAAALFNQILPLLMERTLEDQERHLLVKVIEPLLIDEDYYARAEGREIISNLAKASLAHMIATMRPDIDHVDEYVRNTTARAFSVVASALGV---PALLPFLKAVCRSKK-SWQARHTGVRIIQQIALLLGCSILPH-LKNLVDCIGHGL--EDEQQKVRIMTALSLSALAEAATPYGI--EAFDSVLKPLWSGVQRHRGKSLAAFLKATGFIIPLMEPEYASHFTRRIMKILLREFNSPDEEMKKIVLKVVSQCASTDGVT---------------------PEYLRTDVLPEFFHCFWSRRMASDRR------SYKQVVETTVVLAQQVGSRQIVERVVNNFKDESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFAFQEQSVEEKVILTCFSTVVNALGTRC-KPYLPQIVSTILYRLNNKSANVREQAADLVSSITIVLKA------------CGEEALMRKLGVVLYEYLG---EEYPEVLGSILGAIKAIVSVVMSSMQPPIRDLLPRLTPILRN---------------RHEKVQENTIDLVGKIADRGSEYVSAREWMRICFELIDMLK---AHKKSIRRAAVNTFGYISKAIGPQ------DVLATLLNNLKV-QERQNRVCTTVAIAIVAETCM------PFTVVPALMADYRTPEM--NVQNGVLKSLAFMFEYIGEQARDYVYAITPLLADALM-----------DRDAVHRQTAASVIKHLSLGCVG---------LGVEDAMIHLLNILWPNILEESPH--VINAVREGIDGIRNCIGV--------GPIMAYLVQGLFHPSRKVRNTYWTSYNSAYVQSADAMVP 1166
5 -52.700[YU] KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily)  ali follow..  12  3LSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGN--QNYPLLLLTLL-EKSQDNVIKVCASVTFKNYIKRN-----------WRIICEADRVAIKANIVHLMLSSPEQIQQLSDAISIIGREDFP-QKWPDLLTEMVNRFQSGDFHV---NGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFSTHANDASALRILFSSLILISKLFYSPEFWEGNMETWMNNFHTLLTLDNKLLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGQDLLVSNAIQFLASVCERPHNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYI--RRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEVNWKHKDAAIYLVTSLASKAQTNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPK----EHLLVSIPLLINHLQAGSIVVHTYAAHALERLFTMRG----PNNATLFTAAEIAPFVEILLTNLFKALTLPGSSENEY---IMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSK----------PHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLW-ERTGNIPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPESVDQYRKQIFILLFQRLQNSKTTKKSFLVFINLYCIKYGALALQEIFDGIQPK--------MFGMVLEKIIIPEIQKVSGNVEKKICAVG-----ITNLLTECPPMMDTEYTKTPLLQSLIGLFELPEDDTIPD.................. 886
6 -49.700[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali follow..  11  1.....MDDIPTLLARTLNPT--TSKSAEEALKVW-ELQDSSFALKLLNIVAEDTVDINIKLAASLYFKNYIKKH-----------WDSISDEVAELIKREIINLMLKSTTIIQQLGEVIGYIANFDFP-DRWDTLLPDLISKLSAVDMNT--NIAVLSTAHAIFKRWRPLFRSDALFLEIKYVLDRFRNGPQDAESLNSLFQVILLECKLFYDLNCQEDHMSEFMTAFLNYFTYTNPKVKASICEIVELYTLRYEEMLYDFVNVTWTLLTTLTPDEKYDGLVGKAMAFLTSVIRIRAEFFQQDQVLQQFIELVVLPNICLRESDEELFEDDPLEYV--RRDLEGSNSDSRARSAIVLVRGLLDHFDQKITSVVSTHINANLQSLEWNKKYVALQLFSAIAIKGQSTLMVDVVAFFENNIKPDLLQPAGVIHPMVLAEDIKYVFTFRNQLNSQQLIDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNHVH-----IFTSLLIAPHILPALNQLFLIVESASTPQKLAENDYLKAVMRIIIMSQEAILPAASLLLQHLTKITEEVSKNPSNPK----------FNHYLFESIGALIRSLSKSGPQTVSQLENALLPVFQNVLIEDVTEFIPYVLQLLSQLVEASGNELPDFVVNLIQPCLSPALWDSKGNIPALVRLLRAMIFRGPQIFISNKFVEPVLGIFQKLISSKVNDHFGFDLLDRV--FTVFNANILAPYINHIFFLLLSRLK--NSRTERFVLRCTIFFFFVASEQTGTCGPDNLIQGVDAVQSGVFGQLMTSIILPQAQKLALPLDRKISALG-----LLRLLTCDLVLAPDAIYENLIIPLLTCILK........................... 872
7 -49.300[YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily)  ali follow..  11  1MQ---VDPVVYQLQRAVSQDPIAVKDAEGHLNNWKKE--PGFFGKLYSIFLDKQNDMSLRWIAIIQLRNSIDII-----------WRKLLPEERDFIRCNALLGSIKSENLLSQNALVVSRIARLDYP-TEWPSLFHDLLGKLQQGTGDYDVALRLLITLHHIIKAMAGN-SRQIFYKLAPELLTILQP--SYMQISRYTLKACRRLVVFGFQNPSESEFSERMLAFCAVHQSSRSPIVVGECLEMAFAHAFLFNKLHYDFLGQISSHLSSYKEKFEEEKLVIMSLRVFILVIQEFCNTKSSHPETAQVLYNSFLV-DNRINNLLDLLITKLLILKEEDEQSTQDVEFNVRPCAEKLLKCFFDAYGDIIVSPFKDMIYSVFECTQAVQQDTLISSFGVGYTQLKSIF--PFAKWLQEAAVPNMASINRVYRRRIAIFLSQWIEDSSSEQLLEVIYKLYCSFLNLTDPCND-VILTTIDAFKTVLDDW----------NFSENSFLSIKENLFVHVLSLFKAFESVD--ARTSILSLLGTLLARAGEHVAPMESTIASLLSQLWDGWKKEP-------------LLRARVLAVMHQFVNAIKAKS-FEFSTFLYTVIEYCVNPESPEHVIFEADAMELWSTFLMYI-QKLPETFTLLIPHLLYHLSQATST----------------------------------------------PFVLMIVSSYQLLDNTVLMKYSFTIFEKLNDLLDDVKNET-----------LQALCKTVCLLIETTPMDM----------SLLNSSLLSRLLLSIATNDKHPQVLIEYLLVVSRISLREPELILKVCQTMLIGNWILLNDHINHSKDRKLNTLALSSLLRTNHPDVLA 878
8 -45.300[O] COG5656 Importin, protein involved in nuclear import  ali follow..  10  2VQEQ---AILSCIEQTMVADAKIIKEAEQQLFEFQKQ--PGFTSFLLNIVSDDNFALNVRLSSAIYLKNKIHRS-----------WDTIKADEKLSIKERLIETLCENNHIRPILTETINGILVGQED-WDLAPIIKNLLS-----SGDASYIYPGLLLLFQLCKAHRWDMVGSRIDSVIEELFPIVEGDYRSNEILYLILKSFKYACLNLPQYFSQPERIMSWVQLHLYLCSKPLPKVNKWGFGNLNRFLQRYNKITKAITKEFIDYIFNTIVPI-SDSSLYFLISFLEKCVTIDQLYPLIEPHLQIIFENVIFPCLCANEQSIELLEDDQEEYTRR--YFDINREGSTPDAASADFIFLIGSKRPEKLNNILPFINDIFTRNMAFKEEGALRTLSNLFSFIDEPSLENIFGHFI--VPLLSQDKYMFLVARSLETIALYSEEFKDMNILSQLFELTYTNF--LNSNVLPVQIEAADAIKCLIVS----------NPQIHPAVSAHVPGMMEKLLKLSKIFEID------ILSEVMEALVERFSDELSPFAKDLASNLVEQFLRIAQALVENPSETYSASDQEQEIQASGLLQTMTTMVMSMNKVPLIESLAPVVKFVVLHAQISFITEAVDLLDALTISSHLLYNQIAPPIWELLHDILDSFQT-YAMDYFEAYSIFFETIVMTGFPQDQTYVQPLLEILSAKLESEVD--YDIEHVMQILMYFALSM-----RDIPLFSKAIKVSTN---DELGLDSKCIVKLGLANLFAKPIETLQIMENEGFTINFFTNWFNEKFYSVFAIILTLLKMPEVPNSVSPLLNNLTNKLVELT................................................. 851
9 -42.100[U] KOG2081 Nuclear transport regulator  ali follow..  10  1MDTYSVDVVYQAISALFQGNPKEQEKANKWLQDFQKSIYS----TIADELLHQKRDLHANYFAAQTMRNKIQNS-----------FSELPPHTHESLRDSLITHIGDEQTDNVIVTQLSLAVADLALLMASWREPINDLLVTLAPHQCAI---WPLLEVLKVLPEEIDSKQLDASAECVLKFLCMCLQRDLDQQRVWNAALRTYSAAFRLLSLPETSGKLHDNATECVCALLAHEDTDKTINYCRIFTSLCDAFFYDLPHYSLKGLDLVLLCV-GHFDYEVAEITFHLWYKLSEDLFQRNED-------------KLTVLFRPHIERLISALFRHSQDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQA-PETTWESTEAALFIMQNVAKNILPD--NEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCDWIEN---HPESLEAVLNFLLYALQQKNGLAPAAAIALTSICSAC-------------RQKMVCHISGLVEIARSLDSFQINNDVAIG--LLKGISLILTRLPEQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILNDAWQLISRVMDQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSEGGLLEMLQAFIEPTFGLLQMENGLKNNPDTLLQS-------------SLITPIFQCALIACSLDHREANSSVMKFFINLLVWGRSN--------SRNTECRPLVVELASQHGGALVMNLIQASVFQLHSYML-VDVAEVLHELKQVVGNERMQPFLAQALEALPKKNSGGYVTATQQQLDEFSSTVLRADTTKAIS 903
10 -40.900[YU] COG5101 Importin beta-related nuclear transport receptor  ali follow..  11  1MEG-DIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNP------QKADQILQFSTNPQSKFIALSILDKLITRK-----------WKLLPNDHRIGIRNFVVGMIKTQKNLINKSDLTLVQILKQEWP-QNWPEFIPELIGSSSS---SVNVCENNMIVLKLLSEEVFDFSAEQMTQEQIFKLCFQVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETN---ILELLSTKF--TSPDTRAITLKCLTEVSNLKIP--QSFLQDLAMFLTTYLARIEERELFKTTLDYWHNLVADSQAISTGSGALNPEYMKRFPLKKHIYEEICSQLRLVIIENMVRPEE-KESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWHNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLDLTKDNKAVVASDIMYVVGQYPRFLKAH--WNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKCKYHFVIQQ-----PRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIIISEERSVAER-NRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANIIKTNVAVCTSMGADFYPQLGHIYYNMLVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNR-------DVEVNGLQIALDLVKNIERMGN-VPFANEFHKNYFFIFVSETFFVLTDSDHKSGF-SKQALLLMKLISLVYDNKISVP-SQYLANMLSNAFPHLTSEQIASFLSALVVFKGTLRDFLVQ 1038
11 -39.000[YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily)  ali follow..  8  1MDGNEIAHAKKLVYDLYSGSPSAIAATEKELQKAQRSQQGNIGLFML-----QSKDVYEQFFGALTLQMKINTQ-----------LETLSDKDLVQLFVQLLQKLGLPALVERKVICTLASLT-IKYELEKKEEASLKVIYCLFCNKLSSRNAQLTASYINELLLELSFSIYTKENEVFIFTNYSLDLSKEKNVAALEEALNCMIACMDLTVNCIALDEVSEKAMNCLADLLADSGEENDYSFLNIVIGFAEAMLPQIIDHIQELLYILASLLSAIVEEKVSWRTLEFWTTLIEDFSMSKAATDPSKDEIFKQI--AFSVVEKAWWKMLLPSPEQWNSWPSSSRDSFNSYRRDLGDLLESSYSIFGERLYAMYITTIENFFSDGSPQSLEVSFYCLCCILEYDDSDTLDAWLTRLFETSFAIKAFQNPQLLKTCSQLLSSCSCFLQNH--PQYLNISLPVLFDALHISETSIQMTVSRSIHTLCTTCASH-------------LLTEIDGFMAVVEELTPKLVYVP-SVLEKIYSSVGYVTQRIEELRISYLMRLLNCILAQLQPSLYPNLEIFENVLKSCLQSVAGVA-EQSTQETTFWQQSCIAEFQAKLISFLTHSESMALQ-YSDVVGLICKIMIAGLNEVEPSPFSLPIVTTIQYFCDRFTEFPAAVLLTLGSAILTCPYGQTDIIDKVLIDMCSSIQNSVESFMNNIDITVELYHFFSIILQKHPSFLETMYPDFTQLILNRAINLLGKPERLLE-------SAAGQFIISFIT--SEKSDLLNTHTDFVNAIRSPLIAKILLGFGGNASRSSL-PLLSDILGKLKAQNFSATRACLTQ----SLEEEGFPSRNVSNEIKRRFLTDLLKARIKDKVKQ 970
12 -30.000[S] KOG0212 Uncharacterized conserved protein  ali follow..  10  1......................................................................................................................................MDNLLVRGLTHKLYD--KRKATAYELERVVKGYLENDETEKIRAVISQLANDFVSPARGPNATFGGLIGLAAVAIALGPKI--DSYMESILLPVLYCFNDSDSKIRYYACESMYNIGKVAKGEVFRYFNLIFDVLCKLF-ADTEITVKNGAELLDRLIKDIVMQQAATYMSSAE------------------------------DIKNFKEGPVSSSIQDVPVMSTEQPRMHTFSLSELVPLLSERLYVINPNTRMFLVSWIRLLDSIPDLEFI-SYLPFLLDGLMNYLSDPNESIRIVTSNCLYDFLREIQKIAKVKYHILQRDEESEPDFFDSMVRRNMSDAELKEISDYVES--SLRDGSFILEAHIQIDYKRILEIIIDHLG---SSVPLIQEKALKWLFEFIYIAPKDVLLQIPKVLENLLPLMSN-----DENMRQSAKDLSQNLVILVSKIMDIEFSGSETNNKDNSLSDFRSLIEVLQKLLSNDNEETRLCALEWVLLLQRRTGGKLINMHDPIFQTLLLQLSDPSD-LVVSRTLELLAHIAISHKS---VNLVPFLKSLLQMFAEDRKFLNSRGNLI--IRQLCNYIEGE-LELASIMVEVLNNNL---TAPELYDLRKKLKQSAPKLQNIFTTLYTAWCHNSIAVFSL--LLSQNYEHAANLLSVF------EIEFNIDMLIQLDKLVQLIESPVFTYMRLQLLEPILMLLPQSSAFRTLRDRLQCSSTPR......... 709
13 -25.500[S] COG5369 Uncharacterized conserved protein  ali follow..  8  10..........................................SSFFKENPKIFKDEHE--LLRYI-FKNWVIGRPDR--------------------KEYAIRN-----------------------------GAPKLLLNLFSLENLSMNEKYQVFVVLNSLMSEDQDPFVQFLRHEDLLSVMQMISKRDSTYGMLNITLKVFNTMLSFYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHILYNSKVGDSPRFCSALFQITNRATQLRLYSRR---------------------------------------------------------------DCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVAL---DEYITQLFCLVRQFDPCIRLLSISCLVTLYK-ILSKNQTKEIQMIVTPILIRLFFESREAKQIAPRILAIIINENEIMQKTAVNAG------------FIDAAKYLLEYATKEDELQSSAACECLLSLSRSVYILRTGLADAVSEPLIKLLSD---------------PDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNIS---TKDSSLRKKTVWVLRHVVFGDDETIQLEPKIGASKLVELCND-EDLGVQEQMLQVLRNFTCQKEESVDFLLKMLAKILLEKLESKNP--ILIEPSIYILVHIAASDGELRDSILRQLLLLVKEIMLQEAQ-----------RLKPEQMSTNVSSPESDSEMDLQEDDFDREMRPPFDIYEEDT------YEPNSEILLAGIWLCINILWPKQCT-ASILQNLGFGECLQMLQNHSSPDVRERVKDALMYIN......... 726
14 -25.500[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  8  10..........................................SSFFKENPKIFKDEHE--LLRYI-FKNWVIGRPDR--------------------KEYAIRN-----------------------------GAPKLLLNLFSLENLSMNEKYQVFVVLNSLMSEDQDPFVQFLRHEDLLSVMQMISKRDSTYGMLNITLKVFNTMLSFYVTQLHSDSIINQMFDLYTLPLKEQPSLDVLRISNLSSKILHILYNSKVGDSPRFCSALFQITNRATQLRLYSRR---------------------------------------------------------------DCSILITNSLGTLNAYLKQHVKSYKQREKTRLESNGHVSPRDMDLDEIENVFEGNKDKVAL---DEYITQLFCLVRQFDPCIRLLSISCLVTLYK-ILSKNQTKEIQMIVTPILIRLFFESREAKQIAPRILAIIINENEIMQKTAVNAG------------FIDAAKYLLEYATKEDELQSSAACECLLSLSRSVYILRTGLADAVSEPLIKLLSD---------------PDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNIS---TKDSSLRKKTVWVLRHVVFGDDETIQLEPKIGASKLVELCND-EDLGVQEQMLQVLRNFTCQKEESVDFLLKMLAKILLEKLESKNP--ILIEPSIYILVHIAASDGELRDSILRQLLLLVKEIMLQEAQ-----------RLKPEQMSTNVSSPESDSEMDLQEDDFDREMRPPFDIYEEDT------YEPNSEILLAGIWLCINILWPKQCT-ASILQNLGFGECLQMLQNHSSPDVRERVKDALMYIN......... 726
15 -24.700[BD] COG5098 Chromosome condensation complex Condensin, subunit D2  ali follow..  9  212.VSSLKMFIQRILAMCVKNHGQSSSIQSSLMTNLTYFL--HLSVFNAELLKLLNDEYNYPQLTEDILKEISTRVFNAKDTTGPKAISNFLIKLSELSPGIMLRQMNSSITLRCSVVEACGNIVAELAQDPQ-AVLIELLEERFQ--DSNPYVRTKAIQGCSKICDL--SSKFNKSKAKFTSLAVRSL--QDRSSLVRRNSVKLLSKLLLYYKDAISFIKEIHKSIELISNLLFSKNRNEVLESMDFLVLADAFDIELSEFGIKKMLHLVWMKGTNDEGTSISVHLIECYKQLFLTAPDSCNMQEKAAHIAKNLINLSIGASIADLASLEQLLGMMYEQKLIDQH--------VINILWAIYNSASKASMQKEQNVNNRDSEKGFSKEQIHGSIIILGMLSLA-DNEIALKGLESLLNIGLGAVGLKDLTLCRYSCLALERMVPKRSTIITKAINQELEDVAVKKLYA---PMCEQALSALFTISSK-------------PDILATDLIREKTMMTFGKPEEEDSILQSSRVVSLSQLLFIVGQVAIKTLVYLEKCEAEFKKRKIEAETRNGKVKNQGADVTNTTQDNGGDKELEMIGGTNEDDFTDAIQFVKENVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSK----YCEKSLPLLITVMEKSPDPTIRSNAVLGLGDMAVCFNNLVDENTDYLYRRL------HDENLMVQRTCLMTVTFLILAGQVKVKGQLGEMAKCLD---------------NPDQGISDMCRLFFTELASK---------------NAIYNGFIDIFSNLSSDDLLGKESFKKIIKFLLTFID------KERHQKQLNEKLVGRLRKCETQKQWDDIAFVLNNLP......... 1155
16 -23.100[U] KOG4224 Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting  ali follow..  11  2...................................................................................................................................................................................................................................................................GNCLSCCEKSKDEQYEPLLADREREAVADLLSFLEDRNEVNFYSEEPLRALTILA-----------------------------YSDNLDLQRSAALAFAEITEKDVREVDRETIEPVLFLLQSPDAEIQRAASVALGNLAVNAENKAL----LNGLDLLIRQMMSPHVEVQCNAVGCITNLATL-DENKSKIAHSGALGPLTRLAKSKDIRVQRNATGALLNMTHSYENRQQLVS-------------AGTIPVLVSLLPSSDTD---VQYYCTTSISNIAVDAVHRKRLAQSELVRSLIQLMDT---------------SSPKVQCQAALALRNLASDERYQIE-------SNALPSLLRLLRSSYLPLILASVACIRNISIHPLNESPIIDAGFLRPLVDLLSCTENEEIQCHAVSTLRNLAASSERNKRAIIEAAIQKLRCLILDAPV--SVQSEMTACLAVLALSDEFKSYLLNFGICNVLIPLTDSMSI-----------EVQGNSAAALGNLSSNVDDYSRFIECWDSPAGGIHGYLVRFL------SSEDSTFAHIAAWTIVQLLEAGVPRLTAFIQSSDDIIELLNDIVARDANNGEYEDGEGDVIL......... 535
17 -22.700[C] COG1413 FOG: HEAT repeat  ali follow..  14  10FKTYKLELFFFSILVVLSYALFSGNDSGTGTESMNNYFWVPSTVMQ------SIAAVYAVFIAIFALSLQ-----------------------NLDSIHSIANRL--KPPLKIVSYTAVGSI----------NGLMLIIFSLH--SPSELKIELMLFTSLLSL--------------------------VASLIAIVYLSMEMLSDV--------------LKTSSEKFTYLTNLLRELEGWSSSGQMELSPGDMELCVQGL------------EDEKPEVRIAAAQLLGWLGDEQ----------------------------------------------------------------------------AVDALLRKLADKNPRVREAAVEALGRVGD-----------ENIVAELIGCLEDKNKGLRLQAVRALSRLGD-----------ERAVDPLVKKLEDKAPEVQAAAAEALGNLKS-----------------------QDSMDVLLKKLEESPGAPTEFQVQVLTALGKIGD----------EKALAAILSRLDS---------------PYPDIRKHAAEALGNLRDE--------------KAVPHLVKKLADISPEVRNASVYALGNLGD----------ERAVSPLLRMLEE-PDPELRITAVYALGNLRA----------PQAISPLINMLDDDN--PWVRKCTAEALGKIGD----------IKATDPLVKNLDDPDSNVRWAAAEALRMLDKR--DLRKDSNGNL...................................................................................................... 508
18 -22.200[OZ] COG5234 Beta-tubulin folding cofactor D  ali follow..  9  1MEEEITSRLSQILDDVLHSVEKLKDVAVKYLQFCQFQLLSKYVPNLASYLLKVKNIGKCNSITVILYKAVRV----------------FPVGVQY---KELYTLLNESSNNTWHFHYIVLL----------WLSQALNTPFPLNSLDDSLDVKKTIYTIAIKYLE--------------------------NSGIDKEASCLVLSRLF----SRDDGLDLLLGFLHHCESSWFKRSIFYKIGCLFSLSSFLKIPRNDCLQTVDVAFQFLNVALVGQENSALRKLLCKCYTRLG-LPVNSSPNWKYSISNPDSFFQLPDDSNEEVHIYLEVIVDFLLSSVSDIDSFVRWSAAKGLAKIISRLPWNLAEQVIDAIIELMTENISITSPLVWHGAILFFAKLAG--AGLIKYSKCLHILPLIEVGLSYEVQSIRDASCYFVWSFYHCYSKSAIEGLQTNLILCLLTVLFDNEINVRRAATAALFEVI-SVTDISNCYGDLCMKVAHFPQFRSCVFQRLFTNLQHWDVK---VQQLSAFSLRQLSIKYPKELSIYLPPILDYLSVGLASIIGGFLSISFPFDINRIHDLLSHIILGILKGIQQIFANDIRVDRAFFSEAFSVIIAAIDLQEETIIKDISDAYSVLVKFDDME------ETLEVLLDYIRKCSTSKEARIVYIILQNLPNISFRYQKKICKLLLDIY-----PQLHSIDYQAPVANALQNIIPFTYEK-TESIEEFVKELLQVCSNYLTDTR----DVGSWIRKPAMKAISSLLVKDSSGKKLSEDIVWCC---ISYIIRQTF------DKIDSLRGLAYQALEQIRVH-----IPNLRLQAFYGITVFTADGFGSDLAVKCFEFYLSYVYQLEDSFKK 935
19 -22.100[S] KOG1949 Uncharacterized conserved protein  ali follow..  9  27WNINFIKMIHGTIKNQLQGLQKSKKASGKILEAIENDCIQDFMFHGIHLPRRSPVHSKVREVLSYFHHQ-------------KKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVIRDPNLHAIEMDSKIQKQFEELYSEDPYPMVRSTGILGVCKITSKYWEMMPPTILIDLLKKVTGELAFDTSSADVRCSVFKCLPMIL----DNKLSHPLLEQLLPALRYSLHDNSEKVRVAFVDMLLKIKAVRAAKFWKIMEHILVRL-----ETDSRPVSRRLVSLIVTLVQMNHAAARRFYQYAHEHTACTNIAK--LIHVIRHCLNACIQRAVREPPEDEEEEDGREKENVTVLDKTLSVNDVACMAGLLEIIVILWKSIDRSMEN----------NKEAKLYTINKFASVLPEYLKVFKDDR------CKIPLFMLMSFMPASAVPPFSCGVISTLRSREEGAVDKSYCTLLDCLCS-------------------GQVGHILELVDNWLPTEHAQAKSNTASKGRVALVYIEYLLTHPKNHLLKALETSKADLESLLQT-PGGKPRGFSEAAAPRAFGLHCRLSIHLQHKFCSEGKVYLSMLEDTGFKILSFIQDQEEDYLKLHRVIYQQIIQTYLTVCKDVVMQFQMQLLQRSLGIMQTVKGFFYVSLLLDILKEITGSS-AMLLDTVQKVFQKMLECIARSFRKQPEEGLRVSDVEELTPPEHLS----LPPFSRCLIGIIIKSSNVVRSFLDELKACVASNDIEAAVHIILVINAGKHKSSKVREVAATVHRKLKTFMEITLEEDSIERFLYESSSRTLGELLNS.................................................. 888
20 -21.800[BD] COG5218 Chromosome condensation complex Condensin, subunit G  ali follow..  10  1......MSCIQIISSSQTSIAGHRKLCNK-LFTLRTQE-TDILRALNIILTVKKGNSNADRVLRFLVTFVNYLQQKDPEIDIVQ-----------PILKHILRGLDAKDKTVRRCCQIIARVVVKEIDDDLYNTLKEKLLSRV--LDRESIVRLEAVVALSRLQEDTGDE------ENDVRNILLFLLQNDPSSEVRRSVLLNIE--------------VSNSTLPFILERARDVDAANRKCVYARVLPKIGDFRYLSIKKRVRIL----KWGLNDRDESVEKAAADMLADVAVLAIKKFFDVRVDSLSQLEFPEQFWLELTAESSLLARTFNEICIEKNYTDLLDKMPIERQYVSLRDKSSYDESCFIIEQLLY-IGLSQDMVDEIGRRKLLKSLTNSLS--TMALPDSLISLHIELLRKLCSSENDFCS-LLVEIITEVFEQGHSQNQTEEQGNSNAPELNKNDYEGEEITVSQKSPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSYVQCLFENITSSLNENLYMVDMLKTLIIPAVRSHDL-------------------------------------PIREKGLECLSLVCL-----------DLAFENVPLYLHCYEKGSVVLKCTAIRTLTDMLIQHGAKFTEYEDAISSILFEALGEFENAELQTLGAEAIAKLLVILHYRDELFLKPLIIQYFEPNTVDNH--ALRQVLGYFFPVYAFGAHENQWRIATIFCDALLSLLEIYRDLDEDDVQLSIGHIAQQMLDWTDNEKLYERKTQTGDDYIALNHNVHLHLANMIFESLPNASE--GKERKFMISLLGKL------KIPTDLPSSDYQRTKLETYESHGFTMDSTSLSILAKFERMLLQNEEA 821
21 -20.700[U] COG5096 Vesicle coat complex, various subunits  ali follow..  12  25......................................................................................................................................................................................................................................................................................................................................................ESKNDYVKISAMKTILRVV--INGDSLPSILMHVIRFVMPSRNKELKKLLYYYWEVCPKYNNDGTMKQEMILACNSFRNDLQHPNEFIRGATLRFLCKLKE-------PELLDPLIPTVRQCLEHRHAYVRKNAILAVFSIYQV-------------SNHLIPDAASLAEDFLA------AESEGTCKRNALIVLFTI--------PEKAKAWLLANFEQIPSLNA----------------SLLVIIEFIRKVVLTKADG------LEKLRFQSLLVSLTATNNSSVVFEAATSVINVFPD-----AESLKLAASRLLALADREADNNAKLIMLDRISQLAARDKSILEDLITDVIPFL------SSSDFDVCEKAISIIMGLVSSRN------VEDILNHFQKELTKSNGETEKDD-----GRRRALTKAIHSCAINFPHTAA-----------AIQYLLSHI------SDFQSKSASSVLSFIKEVMEKF-----PDLRSSNITKLLLSLKELRAGKIFRGVIWIAGEYCLTEDDI... 464
22 -20.600[O] KOG4413 26S proteasome regulatory complex, subunit PSMD5  ali follow..  9  1.....MEDVNQLFDAAFEFAHYPGAQNETSVKEFLDR-----LPVIFNALQTDPDIPGFENTLVTCLERLFKTKY--------------GASLIPQYMPVLQVGLKADSAVVKSLA-------------------CKTVLCLLEDCDTNDVSSVQLV-----------------VNNGIYPLLLDYI--INSDDEVANAASETIKSLARFPDAMSVIFPSETNDPTHLRNLAARCSSLARVRVLSLIVKLFSISRLVASEVKKSLLDLLEAEMKGTKDTLVILNVLELYYELMEVEHSSEFVPQ---------------------TSLIQLLCSIISGTSTGPYEKLRAMRLLSKENIYKVVEEASVKALISAIDGSLESVEMNDTDAQEAAIDALGQMGSTTKDLVLSTSPPAARHVVASAFDRNAHGKQLAALHALANIAGCLIYDAAAQSTKLTPSGLFLSVLQQSSEIRLAGYRTLTALVARPWCLVEILAK------------EEIINIVTDATTETAKIAMEARYNCCKAIHEAFLCSNFVDDPRRLKTGDKLQEAVRS............................................................................................................................................................................................................................................................................................................................... 498
23 -20.600[U] COG5240 Vesicle coat complex COPI, gamma subunit  ali follow..  9  2...........................................................................SYSKKDDDGDESIFANVNQVTVTQDA-RAFNSSSISPRKSRRLLSKIAYLHFQEKQATELFFGITKLFQHKDPS--LRQFVYIIIKELSVV---------AEDVIMITSSIMKDTGRETIYRPNAIRSLIRVID--------ANTVPAIERILTTGIVDPISAVASAALVSAYHLYPVAKDIVSRWNNEVQDAV-----TSHNVGRKVASSPFFTSTLGYTPNASGISQYHA-------LGLLYRIRRHDSIAMNKLLQLLVSNLGTVSNS------AFVMLIRYISSLMDTQFRDQMVPFLHGWLKSKGDMVNLEVARNMVRL-----KNISDDDLQPVVSVLKIFLSSHRSATRFSAIRTLNELAMTRPHLVH-----SCNLNIESLITDVNRSIATYAITTLLKTGNDES-------------------VDRLMKQIVTFMSDISDN---FKIIVVDAIRSLCLKFPRKQDSMLTFLSNILCD---------------------------------------------------------------EGGYEFKRAAVDAISDMIKYIPE------ERALAELCEFIEDCEYPKIAVRILSILGEEGPKASEP-----TRFIRYIYNRIMLENA--IVRSAAVSALTKFGLNAED---KFVQRSVKVILTRCLEDADDEVRDRAAFSVKALEDRDAFLPVVK......................................................................................................... 568
24 -20.600[U] COG5064 Karyopherin (importin) alpha  ali follow..  10  1MESRYLSDRRSRFKSKGVFKDELRRQREEQQIEIRKQKREESLNKDVEEEADQSQVQMEQQMKDEFLTADVMSDDIELQLGAVTKFRKYHPPIDQVIACGVVDRFSEHHLLQFEAAWALTNIASGTTDQTR-SGAVPRFIQLLSSPEKD--VREQVVWALGNIAGDSSACRDYVLGNGVLQPLLNILQSSASDVSMLRNATWTLSNLCR--KNPPPNWSTISVAVPILAKLLYSEDVEIIVDACWAISYLSDGPNEKIGAILDVGCAPRLVELLSSPSVNIQTPALRSVGNIVTGTDAQTQIIIDC------------------------------------------------------------------ALNAFPSLLSHQKENIRKEACWTISNITAGNTQQIQAIIESNLIPPLVHLLSYADYKTKKEACWAISNATSGGLGQPDQIRYLGVIKPLCDMLNGSDNKIIQVALDAIENILKVGEMDRTMDLENI------NQYAVYVEEAMDMIHDLQSSGNNDIYLKAYSIIEKYFSDEDAVEDLAPETNGAFTFGNGPQ............................................................................................................................................................................................................................................................................................................................... 525
25 -19.700[U] KOG1078 Vesicle coat complex COPI, gamma subunit  ali follow..  10  1MAQPLVKKDDDHDDELEYSPFMGIEKGA--------------VLQEARVFNDPQVDPRRCSQV---ITKLLY---------LLNQGESFTKVEATEVFFSVTKLFQSKDTGLRRMVYLIIKELSPS------DEVI-IVTSSLMKDSKIDMYRANAIRVLCRIID---GTLLTQIERYLKQAI------VDKNPVVSSAALVSGLHLLKTNPEIVKR------WSNEVQEGIQSRSALVQFHALALLHQIRQNDRLAVSKLVGSLFYEFLESCLRHKAEMVILEAARAITELDGVT----------------------------------------------------------------------SRELTPAITVLQLFLSSPRPVLRFAAVRTLNKVAM-----THPMAVTNCNIDMESLISDQNRSIATLAITTLLKTGN-------ESSVERLMKQITNFMSDIADEFKIVVVDAIRSLCVK-----------------FPLKYRSLMTFLSNILR--EEGGFEYKRAIVDSIVTIIRDIPDAKESGLLHLCEFI------------------EDCEFTYLSTQILHFLGIEGPNTSDP---------SKYIRYIYNRVHLENATVRAAAVSTLAKFGFM-----VESLKPRITVLLKRCIYDSDDEVRDRAT............................................................................................................................................................................................................... 517
26 -19.600[U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit  ali follow..  11  7FTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTKDVSSLFPDVVNCMQTDN---ELKKLVYLYLMNYAKSQ----------------PDMAIMAVNSFVKDCEDPNPLIRALARTMGCIRV--------DKITEYLCEPLRKKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLI-----ADSNPMVVANAVAALSEISE--HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRL-----SHANSAVVLSAVKVLMKFLELLPKDSDY----------------------------------------------------------------YNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQ-KRPEILKQEIKVFF-----VKYNDPIYVKLEKLDIMIRLAS-------QANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIK-----------------VEQSAERCVSTLLDLIQTKVN---YVVQEAIVVIRDIFRKYPNKYESIIATLCENL------------------DSLDEPDARAAMIWIVGEYAERIDNA---------DELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISE------ETDLIEPTLLDELICHIGSLASVYHKPPNAFVE................................................................................................................................................. 583
27 -19.500[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  9  1MNPSSGTRLRDMIRAIRACKTEERAVVRKECADIRAL------------INEDDPHDRHRNLAKLMFIHMLGYP--------------------HFGQMECLKLIASPGFPEKRIGYLGLMLLLDE------QEVLMLVTNSLKQDHSNQYVVGLALCALGNI---CSAEMARDLAPEVERLI------QFRDPNIRKKAALCSTRIIRKVPDLAEN------FVNAAASLLKEKHHGVLITGVQLCYELCTINDEALEYFRTKCTEGLIKTLRDITDPFLHIRLLRLLRVLGQGDADASDLMTDILAQVA----------------------------TKTESNKNAGNAVLYECVETIMAIEDTNSLRVLAINILGRFLSNRDNNIRYVALNMLMKAIT-------DQAVQRHRVTILECVKDPDASIRKRALELVTLLVN-------ENNVTQLTKELIDYLEISDEDFKEDLSAKICFIVEK-----------------FSPEKLWYIDQMLKVLCEAGK---FVKDDVWHALIVVISNASELHGYTVRALYKSV-----------------LTYSEQETLVRVAVWCIGEYGDLLVNNDPITVTESDAVDVIEDAITRHNSDSTTKAMALVALLKLSSRFPS-----ISERIKDIIVKQKGSLLLEMQQRAIEYNS........................................................................................................................................................................................................... 574
28 -19.300[U] KOG0166 Karyopherin (importin) alpha  ali follow..  10  10...................................................................RLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQIS-GVITSDMIEMIFSKSPEQQL-SATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAG-AVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFA-----------------------------------------------------------------KVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDAN------------IFPALISILQ---TAEFRTRKEAAWAITNATSGGSAEQIKYLLGCIKPLCDLLTV---------------MDSKIVQVALNGLENILRKRNGTGINPYCALIEEALDKIEFLQSHENQEIYQKAFDLIEHYFGTEDED............................................................................................................................................................................................................................................ 510
29 -19.200[S] COG5543 Uncharacterized conserved protein  ali follow..  7  21....TVSSFQQLRETFIQSKSEDWYLKNGLFFRY--------YSFLKSSLENATLDGPSQVACLDTISVWLRRIFNACKQDPEIS-KYVWDTMELKFWTNLFSLPANSIPGLTGVQVAVKDVFSKSLQLYL-NDFLLDSLKHALHWDRH---AKVVCTAIQLLVKVTGAEAVFAFQPDFFEQSLKLL----KDYSYAQAISSTILTVLTLRFKSLSEETEMNIWCPIILYEFYGNDRQVQAGMSSLIPSLLGVSPGITVKFLSRL-HAFVKTLFKHPDIKIQLACFRLIALCPNVSSPLSFEDFDCLESNIEFSFNVLD-SRQILLKSMQDFFIRLRASCHSIARTMRSRHSDKVALSGLLDRA--MQFLTSFISVCKKHLYTCNYQQVLVSLSFLDTLISFGLDDNVESSSRDLSRLMIDRLKDPYDDIRNLCLKILLSYKS-LPGFISDSDAYFLFNHGLELLNAVRSHECDGGAKTIYLCNHFMEKS---------VPGSVLANTKVILNRLKSNIEHAKTSLLEAAVNCLIQLTYIFQSLSESWKNIVMELIKASETIWGLIKDVLCDDSPEGNLPDGEGSLKETSSLLTVLLTKFTPFTLNYYGELMMTWLWEI------RHRGAFTSVYPCFIEYCSFLKHEISELPDPWLHKNLSVIQEKSSFITRRSG--SITAILVAGKDKREQLIEQTVISLISIAKQPVEQKNIQVHAMNTLKTIFHRLSSVSVEYLEPAIALSIEGFSHEL------------PIRNCSVMLFTALINRAFGSKKPKDAVNSKFPTLHDYLLRELEVSVASLSSNDQPSTGLYPILNMFSRLQYAQPYGNENEWTFEPLIFKCTASRICKVREIASLSLTCL.......... 993
30 -18.800[U] KOG1077 Vesicle coat complex AP-2, alpha subunit  ali follow..  8  2....................................RGLAVFISDIRNCKSKEAEVKRINKELA--IRSKFKGDKTLDGYQKKKYVCKL-----DFGHMEAVNLLSSNKYSEKQIGYLFISVLVNT------SDLIRLIIQSIKNDSRNPVHVNLALQCIANIGS-------RDMAESFSNEIPKLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGE----WTSRIIHLLNDQHMGVVTAATSLIDALVKRNPDEYKGCVNLAVSRLSRIVTASPAPWLSVKLLRLLQNYNPVTEE-----------------------AGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIEPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVV--ILSMKMEKDVSVRQMAVDLLYAMCD-------RGNAEEIVQEMLNYLETADYSIREEMVLKVAILAEK-----------------YATDYTWYVDVILNLIRIAGD---YVSEEVWYRVIQIVINREEVQGYAAKTVFEAL-----------------QAPACHENMVKVGGYILGEFGNLIAGDS----RSAPLVQFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVF---RQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEM.......................................................................................................................................................................................... 594
31 -18.700[O] KOG2062 26S proteasome regulatory complex, subunit RPN2/PSMD1  ali follow..  8  7DNTSIITSAGGLMALLDEQERELQVHALLKIYEFIDQLWPEISDDVTKI-MYEDHSFPERELAALVVSKVYYY-------------GEYDEALLFALSSGPKFLHDKNSDYKETLIFKCIDMFIHKSAELY-DERLSGVVEGIFQKCYAKNEWRHVLGIAIEALDIIEYILNADKETDLKPYVLELAMTVVLDIEFRNRLLRLLLSSFLTETEPDYFSNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMD-CGYIIRILSGEQTVKYDREFLY--DMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDNLSWLSKANN--------SKFTATAALGVIHRGYYNQAMNILRPYLEEDAPSSSTYSEGGAFYAMGLIHANHGRGVTEYLREQLK-------HTEDEIVQYGLLLGIGLTG-------MASRDETLYESVKTILFNDNAVAGSAAGISMGLIMLGTAS-------------------SAAIDEMLQYAHETQHEK--IIRGLGIGIALIVYGRQQEADGIIKELNN----------------------DLDPTLRYAGMFATALAYCGTSN------SKIVRDVLHISVS---DVNDDVRRAAVCALGFICFK---------PNALISTVELLVDSYNPHVRYGSAIALGIACANSGS------NAALDLLSRLVEDATD--FVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEQVINEKHEDA................................................................................................................................ 707
32 -18.700[O] COG5116 26S proteasome regulatory complex component  ali follow..  8  7DNTSIITSAGGLMALLDEQERELQVHALLKIYEFIDQLWPEISDDVTKI-MYEDHSFPERELAALVVSKVYYY-------------GEYDEALLFALSSGPKFLHDKNSDYKETLIFKCIDMFIHKSAELY-DERLSGVVEGIFQKCYAKNEWRHVLGIAIEALDIIEYILNADKETDLKPYVLELAMTVVLDIEFRNRLLRLLLSSFLTETEPDYFSNDASVAAKLLMKLSSQNDDKSLLTAYQLAFDLEDSAPQEFLNSVMD-CGYIIRILSGEQTVKYDREFLY--DMLILNRTKDSLEARNSVFHNAVTFANAFMNFGTSSDSFFRDNLSWLSKANN--------SKFTATAALGVIHRGYYNQAMNILRPYLEEDAPSSSTYSEGGAFYAMGLIHANHGRGVTEYLREQLK-------HTEDEIVQYGLLLGIGLTG-------MASRDETLYESVKTILFNDNAVAGSAAGISMGLIMLGTAS-------------------SAAIDEMLQYAHETQHEK--IIRGLGIGIALIVYGRQQEADGIIKELNN----------------------DLDPTLRYAGMFATALAYCGTSN------SKIVRDVLHISVS---DVNDDVRRAAVCALGFICFK---------PNALISTVELLVDSYNPHVRYGSAIALGIACANSGS------NAALDLLSRLVEDATD--FVRQGAMIAQAMILTQHNDQLNSKVSGIRKHFEQVINEKHEDA................................................................................................................................ 707
33 -17.900[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  8  524.RSLFKIPYHELFCALLKSSSVKQSLLLDGFFRWSQHSMLSLREFIMKALASTSRC--LRVVAAKVLPKILAVENTAILETVILSWISLEEEELHFVLLEVISSVINSGIFYQGIGLSALQQIASTRHISVWQLLSPYWPTVSVAIVQGMGKKPNIASLFAQLMNISEGDFLIRTQAYTLPFLVLTKNKA---------LIVRIAELSQSDVATLCLTN----MHKILASLLTTDHPNLEESVMLLLSLATSDFTSLLRSDPISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNK---------ELLYDFFNNHILGILAEFSNILNDLKGKTSINE---KIKTIVGIEKMLSLCGGAVLPQILSNLQSAFQNEH--LRFYAIKAWFSLILATKEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFISKEIFCSLQNEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELHDTLNLDISNEVLD----QLLRCLLDCCVKYASTNMQISYLAAKNLGELGAIDPSRAKAQHIIKETVVLDNFENGEESLKQLIPAFLVTTDTKAQGFLAYALQEFLKLGGLTVVTEHWMSLPDLSKRVLIPFLTSKYHLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEVNIPCFLLPFLNKVIEEFQLVINGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRFPS--KTLGIVSLNCGFHARALF-YWEQHIRNATAPYAALESDYRVLQEIYAGIDDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKK. 1482
34 -17.900[S] KOG2149 Uncharacterized conserved protein  ali follow..  9  1.................................................MSRSKAPARKQQKKGIDFKK--------IKRKLGRKLPPPNNATNTEIKSKAIIL--HEQSVAAERDGFATSKKGLTLL-----ELKNRT------GHPNAKVRKDALHGIKDLLKHHPAELLSN-KYATTHKLRELIT--DDDKLVRDDFYTLLTGIFLACKEDINKGLMVSSLMPYIFTAMTKSSIEVRLMAFKFFRLVLEFYSPTFSLYAEKILENYKDVIHNNHFKEIVAVLINCFQDFLPLIHASQRINKESFDCIRHILRSIGYAIRDIASMLSKKLLGSFPLNHENNFSVENNGVLTEIFLEVSEWSHLPCDLSNRFLEFIENALLGTRSNSLDKTLLALLPFVPKLLLRVDRDRRDNLMQAFTITFNNPESSLKLACISVVKDLIIPNGDILYPNAWVNKLPSLLNQLGDKHHVSTKVVLQLLLDLARVGCLNASPTFEEEIRSFFLPREVQEVALCFLYYFIIDNFSSPMLKAIVVEILQTAYRGGYIQITDHFSFFITLISRF-EKLNSAIECDERKANCGTFKTLTNLVCSYLSEMGDS----------SLVLQILEKVFVEQIILKPAL--DNGCAILRMICALDSKPTRLSEISVTTLSEFLPG-------------------------------YLIDIVNCIPEDKERSYLYMQTCLYYLLPCYFLFDRSSKLTEQVLKRMRSMVSENVKALESVQDRESGRDSLNLIQCIVSVILLMHNDVKVRKIISSS-KSEIDLILQNVYTLQSSRSTSLTVMKIAAERLSIASNSL................................................. 861
35 -17.600[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  10  8..............................................CYTLIHVPSDAELPSEA---LKEKFEKGGDKER--------------IEALKKLIYMILNGEKTSQSMLMYVIRFCLPSN------KKVLLIFWECVPKTDSNGKLLHEMILVCDAYRKDL----------------------QHPNEFVRGSTLRFLCKL--------REPELLEPLMPAIRACLEHRHSYVRRNAVCAIFTIYKNFEFLIPDAPELVTEYLE----QEQDASCKRNAFMMLLHVDQ----------------------------ARALDYLSGCIDQVGSFGD-----------LQLVIVELIYKVCHNN--SRFIRCVYNLLQSSSPAVRYEAAGTLVTLSN--VPAAVKAAASAYIDLIV---KESDNNVKLIVLDRLVALRGSSSN---EKILQGLVMDILRVLSSPGLEVRKKTLSLALDLVSSRN---------------VEDMVMFLKKEINKTATESNDENGKYRQELVKTLHAATIKFPDVASTIVPVLMEFL----------------------------------------------------------------SDTNEKASSYVLQFVREAVH----KLPNLKNAILGALREGIPFIQSPTIFMSALWILATYCEADGA------LDVLKLVKNSLG--ELPLVDSELSGQEEQKPEEQQPEQQQKQKPKVTA............................................................................................................................................. 517
36 -17.300[T] KOG4500 Rho/Rac GTPase guanine nucleotide exchange factor smgGDS/Vimar  ali follow..  10  5..........................................IDDLIEKLKTTSVSPANTTNLLCEISAT----------------KDPKLFDKHELAECFLGLTKCDDTNVREAAKCIAEITKSEVQRKK-RNIIAAFLECLRQSDGSMELPIQICRALGNICYLNDEARDLILELEGDAVLLRLLDITTNAAQFIKVRGGLLSNYLL--GEGLAKRAMELGVMKKLQGIIDIGASNVEQHTLPLLSILTENVSDLNFD--SSLNIQLSRILAASTNPDLAEMCLELLHYQAESDEVKLILAKD-----------------GLCETIYNLLEKYKTLASTSEARALMKLACELIVLILTGDDSMHYLYTTPLLKNMVDWLDSTDIDLLTTGVLALGNFASHCIYFVEQQTMNKLLEVLAKNNGKDDVRLQHALLSALRNLV---KPNKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALELLKN-----------KTLIEQLVHWSKSSDYAG--VTGESLRLMAWLIKHAYL-------------SKIAYALPRKGDAPAEQIADKIPLTQDYDRSSLSEFLANE--------------GTVEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSEAAQAVGKKLAELISKSSDKEIVENLQNCVNLLKSSEQLVAHLEQHNINELLKSIPILTE.............................................................................................................................................................................. 630
37 -17.100[IG] KOG1340 Prosaposin  ali follow..  9  88.SNQTEEELKEVFEGSCKPIKPIQKECIKVADD--------FLPELVEALASQMNPDQVCSVAGLCNSARIDELYKNGIQAGLDG-----TVQNEDDSSEETELAMQPNQLSCGNCNLLSRLMHSKFAATDRDDMVETMLHMCGSLSS---FSDACANIVLTYFNDIYDHVSKHLTTDAVCHVSGVCASRYHQHEEEKQPQEALVALDAGDDIPCEL----EQLVKHLRDVLVANTTETEKQVMEGFCKQSKGFKDECLSIVDQYYHVIYETLVSKLDANGACCMIGICQKNSASSMKDVPIMPLLPVIEPAQVKITIEKLEKHEKKQLGASEPKFSQQEILDMQLPIDHLMGAANPGALVEGGELCTLCEYMLHFIQETLATPSTDDEKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGSDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDF-----------------------VNTYSNELIDMLITDFKP-------------QEICVQLKLCPKTTYALWDLRISLEDDVDGEDKSSSEEISFNDIESLEELPPQLAFD------PGFTAAPNCLICEELVKTLEKRMGKHPTRD-SIKHILEESCDRMRKPMNTKCHKVIDKYGDKIADLLLKEMDPKLICTELGMCILSSSIKEPPTCVLCEFIMTKLDADLKNKTEQDDIKRAIEAVCNRLPATVRKQCDTFVDGYASAVLKLLSDVPPKQ------------------VCQKLQLCFSVAVTDEVLECGVCHGVTQALLPFLREKKDNVSEVTALQMTSVGCENLPAKYYKICSEMI-SIYGSSIKNLAKRPYIDQ--SHICAEIGKCFESEKSSLA. 947
38 -17.000[S] COG5412 Phage-related protein  ali follow..  10  1MADYTLSGFRAGFQKAQESLANLQSRVNQTGKRVQSKSISDLGSKLTRNITVPAVGAAT-ALTSITLVKGFDRLVGIDSARAKLKGLGHDAEAIDSIMDSALASVKGTAFGLDEAATTAANAVAAGIPPGK--ELTRYLSLTADTAAIAGTSLGEIGAILNKVTTS---RAYNSELQMLSDRGLPVYQWLAEEANTTADAIFDMAS-----KGEISTDMLLNAIEKNIGGAAKIMGEESFSAAIANIGADIARIGANFLDAGGKAGGFFSTVK----------PLLTEFRGFLAQVEEQAADWGVAFGQAFNNVIDRVRELKSWFDGLSPSVQTLITRAVAIGAGFLVGIGPALKVVGFLTTQ------FGSLLNITSLLLSPIGLVVVGITGLAVAFGVAMAKSEEFRNLVFGVFQNLASIISTVIATVSPILQTMWDGAREGLASFA------ETVGGRLINAFELIVTVLQTVVVAVTEFVSSFIQGFQSAGGEVTSLSSLFLGFNPVLSMALLILQEFGPQIAQGFSQIASMALPLLTMLGQTLGELAAAIIPMVMNVISALMP----------------VVMSLGMTIMDLAMAI--PILIDVFSQLLPIITQLVTTFAG--------IIAQVAPLVTILVSSLVPVLMILIETVLNIVQA---APALIAILGAVASAFDAIIPVVMAVLSTVVNVVANIISAISPIVAFVAGIISSIISIISPIVTFIAGIISSIFSVISPITSFVSG--------VFSTVFSIISGVFRNILGTVTSAIRTVSSIISSLSGVVSGVFNRIFSIASS-NRVSSVITGVFNAIQSSWTGLTSFVSGVFSG------IGNAVQRLVNQVKSFVNGVISGINAAIG..... 817
39 -16.900[TW] KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins  ali follow..  8  348DMEMTLERAVSMLEA--HMPPSRISAAATFIQHECFQKSEA-ILKLLQLLKVQN--EDVQRAVCGALRNLVFE----------------DNDNKLEVAERLLQVLKQDLETKKQITDHTVNLRSRNGWPGA-PSTLGGQGGRITRSGVR--DQPDQHGLLWNLSDKLKNLMITEALLTLTENIIYPKANGLLDFDIFYNVTGCLRNMSSAGADGRKAMRRCDGLIDSLVHYVRGTDDKATENCVCILHNLSYQLEAELPEKYSQNIYIQNRNIQTDNNKSIGCFG---------------------------------------------------SRSRKVKEQYQDVPMPEEKSNPKGVEWLWHSIVIRMYLSLIA---KSVRNYTQEASLGALQNLTAG-PTSVAQTVVQKELQHTRKMLHVGDPSVKKTAISLLRNLSLSLQNEIAKETLPDLVSIIPDT-TDLLIETTASACYTLNNIIQNSYQNARDLLNTG-------------IQKIMAISAGDAYASNKASKAASVLLYSLWAHTELH-TDFVNSRTAKAYHSLKD............................................................................................................................................................................................................................................................................................................................... 881
40 -16.800[YU] KOG4541 Nuclear transport receptor exportin 4 (importin beta superfamily)  ali follow..  9  3.........LTTLHALSNQEDIVGNAFTSRLCD-------RFLEVSENILS---------NFSSKLYRRFLSNHQSSTSFRPPISWKDLNDEFFILF--KLHSKIRHDETLCTKSMNCLIQLAS--------------LTGDCMPVADQEASTKYVRMYISSLLELFAQGPSNWETNH-FCLIINRLFLYRPLTSIMRQEPELRARFFGFLRD---------YTIHLTNQAMQKAIGEAEHEDHTSLALIYDAIVVLLRGRWRTCFSSE-EEADAVDNELVKWPTLMIVNAFVSNLLAPPKGTRP----------------------------VAKDEDDGDEDSEDRTLFMDLFNPLGAMICYSVGEFMENMATNLHTSLAEFTAMATTGSMLILANSIVGEEIDGACHVSGDVFDYTQKLFHTGRKFDETKKAQYLQMCIEQPTQDRAQY--------------ALEVDPFIIVMGELFAWASIEHDVFANASREMISPELCRSTFLCLRRFLNAASSSVDCDKWNDYQGVSSENLPVMPQSKEFSAILVRFVIKKVLAVLVNYGSEE-------------KLCQDAIDCLLSLVESHASDIA------SSPELFEYLNSLDIARLPNRANLMKALVLIGAAANDQFKLILVPLSERFVSACDQPTRTDIDSQIVDYLQCFQSHSAPVLFKFLYAIIDKCVGLMRSRNQNELVVSNILQLILDVTTKVSNALYASLLQIVDTYKTDQFQRFSTFTADDEEKATDLA-LFIDILSNVLSKLTLGGENCTNGAKVVIHSLEMLLTIMNDRVLQ----PEVALKFFRLILYLVEFSPESLAE-MSDQLMSSLCQCIRGQFGMEITSTSLESLTEVVLHFGSPANK 818
41 -15.600[R] KOG0567 HEAT repeat-containing protein  ali follow..  15  4.......................................QQQIEAIGGVLNNKERPLKERFRALFTLKNI-----------------------GGAAIEAISKAFDDDSALLKHELAYCLGQM---------AQALDILTKVLKDTTQEPMVRHEAAEAMGAIGH-----------PDVLPILEEYK--QDPVVEVAETCAIALDRV----------------------QSGQKVDDSNPYASVDPSPPTAG----------DKSVTELKAIYLDAQQSFDRYRAMFSLRNLRTEE-------------------------------SVLAIAEGLKDSSA----------LFRHEVAFVLGQLQEPCSIPFLQENLED--RLENEMVRHECAEALGAIAT-----------EDCIQILNRYAEDDKRVVKESCVIALDMC-----------EYENSPEFQYADGLAKLDATK........................................................................................................................................................................................................................................................................................................................................................................................................................... 302
42 -14.600[T] KOG2137 Protein kinase  ali follow..  10  78LDKRALSEARVRANLSKAAEDAFLDLIRADAGKLVRLRHPGVVHVVQALDENKNAMALVTEPLFASVANALGNVENVGNVPKDLKSMEMSLLEVKHGLLQISETLNFLHNNANLIHRAISPENVLITSAGSWK--LAGFGFAISAAQAGNLDNMQSFHYSEYDVEDSILPVQPSLNYTAPELMRSKSPSAGASSDI---SFGCLAYHLVARKPLFDCNNNVKMYMNTLNYITNESFSSIPSELVSDLQRMLSTNESFRSDARLRALRFLDHLLERDNMQKS-----EFLKALSDMWKDFDSRV--------------------LRYKVLPPLCAELRNLV---------QPIILPMVLTIAQSQDRTDFELITLPALVPVLSTASGDTLLLLVKHADLITNKTDSEHLV---SHVLPLLLRAYNDNDVRIQEEVLKRSTSVAKQLDGQVVRQAILPRVHGLALK--TTVAAVRVNALLCLAELVQTLDKPAAIEILETIQRCTAVDRSAPTLMCTLAVANAILKGVEFTAEHVLTLMMPLLTAQQLNVQQF-AKYMLFVKDILRKIEEKRGVTVNDSGVPE............................................................................................................................................................................................................................................................................................................... 630
43 -14.400[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  7  18TEAETIQKLCDRVAS--STLLDDRRNAVRALKSLSKKYRLEVMEHLIHVLQTDRSDSEIIGYALDILYNIISNEEEEEVEE-------------------------NSTRQSEDLGSQFTEIFIKQ------QENVTLLLSLLEEFDFH--VRWPGVKLLTSLLKQLGPQVQQIILVSGVSRLMDLL--ADSREVIRNDGVLLLQALTR-IQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLLKNNNS--GSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRV----------------------------------------------------VSPTNPPGATSSCQKAMFQCGLLQQLCTILMA--TGVPADILTETINTVSEVIRGCQVNQ-NPPRPAIVVLLMSMVNERQPVLRCAVLYCFQCFLY--STIDATGNSVSAGQLLCGGLFSTDSLSNWCAAVALAHALATQKEQLLRVQLATSIGNPPVSLLQQCTNIL------SQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHN-VPFLTGQIAENLGEEEQL-----------VQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIG---------KENFIEKLGFISKHFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIRE-LEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVLKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSA. 852
44 -13.600[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  10  1MPHKIGFVVVSSSGHEDGFSARELMIHAPTVSGWRSPRFCQFPQEIVLQMVERCRIRKLQLLA--MISSKIESLPEYFAPYQAERFRRLCDNEKTGCKARELKSVYVDAV-----------------------QFLKLIFHQNHVNKYNI-YNQVALVAINIIGDPADFSDESNTASREKLIDHYLGHNSEDPALEGTYAISPLDDLAFDMYQDPEVAQIIRKLDERKREAVQKERYDYAKKLKQAIADLQK-----VGERLGRYEVEKRCAVEKEDYDLAKEKKQQM-ISPQHSAVDPLLPATDPHPKINAESLPYDERPLPAIRKHYGEAVVEPEMSNADISDARRGGMLGEPEPLTEKALREASSAIDVLGETLVAEAYCKTWSYREDALLALSKKLMEMPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYIPK------------------------------------------------HKLSKLETAHCVERTIPVLLTRTG---DSSARLRVTAANFIQEMALFKEVKSLQIIPSYL-----------------VQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALE---HRVYEVRETAVRIILDMYRQHQASILEYLNTRRNILYKTIFEG......................................................................................................................................................................................................................... 667
45 -13.600[R] KOG1243 Protein kinase  ali follow..  10  36KRKTTLEEVSVFVYDIRSGSDTKCELAKAALKRLKTLRHPSILQYLDSLETDKMLYVATEAVDP--LGTYFSKLGSDNVQK--------GLYLAWGIFQ-ITRALSFLNNDGNLRHNNVSAWSVFVNASGEWK--LGSLEYVSAADGNPMPPAKIPVTLEVYDSPEKNDP---------------SKLKAATKCSVDMWGLGCLVWEA--QRSNLKDIEHIPKSLQSLYCELVGASPSNRPNPADIITRCRKPG-GFFKNDLVDTLLFLEEIQIKDKAEKN-----RFFSGLTTHLDNFPDNV--------------------CRHKILPQLITAYEYGD---------GSAVLAPMFKLGKLLDEVEYQKRIVPCVVKLFASTDRVTRSRLLQQLDLFIAHLQPQVVN---DQIFPQVAHGFLDTNATIREQTVKSIIHLAPKLNYNNLNVEVLRHFARLQAR--DDQGGIRTNTTVCLGKIAPHLHPQVRQRVLVSAFIRAMRDPFPPARVAGVLALAATQQLLSEVANRVLPSLCSLTVDPEKTVRDPAFKTIRGFLGKLEKVSEDPSLRETMEADVH............................................................................................................................................................................................................................................................................................................... 555
46 -13.400[D] COG5537 Cohesin  ali follow..  7  1............MRFEFESDASSHLNEVLTELESVELENVEYEGPSLQNVSICASPSEKKRKWG---QDEFSLTENEENNEIETNEEMHVNSHDYAFPQEFFLKLLDIDMPLEQLS-------------QHY-TFINFALVASGCTNFDVQDVDSIPETLSQVNRSSFQKSSCAYTDYLY------TSNSKEAKTVRIRFQLFLVEFISKVYVEFLGDSFMETTKAWIFTMTTSPWMLVRHTATTICCDIMRCLCLIVNKLSEKSNQTAEILVLRDLTSRFIDMIHDICDSVLFSRIH----------------------------------------------DIRASIRIVCVTALYDCCQLLPTYLINNLIRHSGWGLSDAESQIRKISLKIIDYLSSHEPEKDVVDFLDRFSLRIVEICRYDIDSVRSVALKTCEKLMEK---ISLNGKCINIVSSCI---FDGKPQNRISTMRILVAHTNERYANYCEAKTATISLSKLLR-MNALLFILEQGFESWFRDSSDHIFSRVKDDDKFVYQSQENNFYDADFIREYDMNNHRQQLIEESMHSIHTNSQLLASWED-VAKLLLYDRFDAKDTNSVLNPCIPSNAVIEFSSIYLHYFATHISKRSKKPGKRLEDEVVNQQQAMLRNLPLLLQKYRESCVSSYFFIKCVEQIPDELLYKREFHKDFSKLYKEILDIFN-STTVNFLMILCSRFFHRLAVN--------------------KVVQEDILFAIDNVYNDLAESLHEQLNAYIQRKKINKKNQLNGNDETQNLVLALNK-FGCFAKEMVCLRDVNDWNIKLSEKLCEICSLEVGPIVCYSSLKVLFLLLL------------SDMRDRNCIFTNIFLK 801
47 -12.800[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  9  470.......GLAEQLKVYICDSSKKEDTRRIAIDIAIECNLSELQGDLAKLTLCPSQPISIRVNAARAISSI--GDQSTRLKLKSLALNVLPEDEQDELKAYALKALWPRQLTAEELFQALTPSKRINLLGMHRYFLESELVPQLDSED------VIALDWLKTQGVRCFGHPFEELGDAILLKAWEHVNVPGVLEGFTQVALLQWKEHQKLISHSPSLQAQFQESL--------LGNNQKRYALIENLVESIAEKDEDEDFYFSNDVDWMLEKLQDSNHEKIQRAWAKIIEEVFDRRDTKQISEIIKATQNNSILSDVFSYYFTPIEEEVTQLRDHYLKMKNSWNKPDLLDPPPKERVIDCLEQLESGDL--RLNREMTLLPQSKRYGHNLKLDLTQLPGWKEAEQATKKRIIQGAIQYIQQQ-TNTYNFSELYGCKALQLILTEAPRTLDN-----------------STDIWKRWTPIILSVPNSFIDSNPRKNCRKLVSLSYHHSPDEFLTTLLKLIDKENQDNNIFVIDRLNNLTEKVKDSQLKPNVFRKLLEKLIEQGAVQAKDIALSTIRNYTNSEFDSERQKALFAIKALITYSDPDSWNVIWEKITA----------------VQFGREAFELAASCNLSGIKFDLTE-IADLYAWLVWQYPHYEDPDHRNEVMAYIVSPRDNIAFFRNNSLSQLRDK----------TIEACAELERLIQELPHL-ETWRPFKPDKLLEFLIIPEPSNLDLSNQ---------LSTIDKRTEKMEDEPKIINNISDSTIN--TSNNVTCSSPEKQKRFNWEILFGVIGIIGVIATVVGIFFNGIFNDVLKDSLNGSPSKIEQQAMPKN.................. 1319
48 -12.600[ODR] KOG4151 Myosin assembly protein/sexual cycle protein and related proteins  ali follow..  8  1............MVARVQTAEEIRDEGNAAVKDQDYIKADELYTEALQLTTDEDKALRPRAMARLKRDDEFDGADVKALFRRSLAREQLGGPAFQDAKEAL--RLSPNDKGIVEVLQRLVKANNDKIKQTT-NKVTDMEKLAFRGEAKDTEQKMTALNNLLVLCRESESGATGVWNQGALVPFVLNLINDSENEEVTVTAIRILDETIKRLMCKKSTKDFVDATGILVQRVFNAMAKMDRQKEMKPDPEVAEANKIWIIRVLLELQEMLQDPKVGAVQRETCIDLFLKNLMHMDGGIPRGWSWKFVEERGLLALLDVASQIRQHVAICLQRLEEDMVFDTKRTDDEGHKYRIKLSCFLITMLQGPVDIGINLITPIMLEMAASQDHLMQGIAAELIVATV--SKHERAINMLKVGIPVLRALYDSEDPTVKVRALVGLCKIGAAGGDDISKATLAKTCKKFLLETEKYSVDIRRYACEGLSYLS---------------LDADVKEWIVDDSLLLKALVLLAKKAGALCVYTLATIYANLSNAFEKPKV---DEEMVKLAQFAKHHVPETHPKDTEEYVEKRVRVEEGAVPACVAVSKTESKNALELIARSLLAFTVLCLRLTKEASGEGKIKAGHAIAKLGAKADPMIS--AYEVVKPLCDLLHPDVEGKANYDSLLTLTNLASVSDSIRGRILKEKAIPKIEEFWFMTDHEHLRAAAAELLLNLLFF-EKFYEETVAPGTDRLKLWVLYSAEVEEE-------RLSRASAAGFAILTE--------DENACARIMDEIKSWPEVFKDIAMHEDAE--TQRRGLMGIANIMHS-SNKLCSEIVSSEVFRVLVAVTKQERAGSTEQAKRGLGLIKATDREIYER 952
49 -12.600[O] COG5110 26S proteasome regulatory complex component  ali follow..  10  42.DAKLKTDLELLVERLKEDDSSLYEASLNALKESIKNSTSSMYPDLCSIYDKWTDPNLKSSLADVLLRYRLLSDVSDFEGWGHEYIRHLALEIGEVYNDQV-AATSGFEFSKEDTLRLCLDIVPYFLKHNGEEDAVDLLLEIESIDKLPQFVDENTFQRVCQYMVACVPLLPPPEDVAFLKTAYSIYLSQNELTDAIALAVRL--GEEDMIRSVFDATSDPVMHKQLAYILAAQKTSFEYEGVQDIIGN------GKLSEHFLYLAKELNLTSSAGLDSAQQNLASSFVNGFLNLGYCNDKLIVDNDNWVYKTKGDGMTSAVASIGSIYQWNLDGLQQLDKYLYVDEPEVKAGALLGIGISASGVHDGEVEPALLLLQDYVTNPDTKISSAAILGLGIAFAGSKNDEVLGLLLPIAA------TDLPIETAAMASLALAHVFVGTCNGDITTSIMDNFLERTAIELKTDWVRFLALALGILYMGQGEQVDDVLETISAIEHPMTS---VLLIQDLLHRLTPKNVKGEEEEETAEGQTNSISDFLGEQVNEPTKNEEAEIEVDEMEVDAEGEEVEVKAEITEKKNGESLEGEEI-----KSEEKKGKSSDKDATTDGKNDDEEEEKEAGIVDELAYAVLGIALIALGEDIGK---EMSLRHFGHLMHYGNEHIRRMVPLAMGIVSVSDPQM------KVFDTLTRFSH--DADLEVSMNSIFAMGLCGAGTNNA------RLAQLLRQLASYYSREQDAL---FITRLAQGLLHLGKGTM-TMDVFNDAHVLNKVTLASILTTAVGLV---------SPSFMLKHHQLFYMLNAGIRPKFILALNDE-----GEPIKVNVRVGQAVETVGQAGRPKKITGWITQS 952
50 -12.400[O] KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2  ali follow..  11  39LSEELKQNLELYVERVQDPNPELQKAALESMRQEIRASTSSMYGTLKAFHETMADSDLKKYLSDILSVLALTMSADGERESLR---GSWGHEYVRNLAGEIAQKRQSEEASIDDLMELVQQIVAFHMKHNAETEAVDLLMDVEDLDLLLEHVDKTNFKRTCNYLTSAARYLPGPDDMLVLDISYMIYMKFEEYPNALQIALQYVKQVFTSCTDLLKKKQFCYMIARHGITFELDDEMVADDDDREALQDIVNN--TKLSEGYLTLARDIEVMEAKTPEDIYK-------AHLLDGRASSGASVDSARQNLAATFVNAFVNAGFGQDKLM-----TVPSDSTTGSSGNWLFKNKEHGKTSAAASLG----VDSGLSQLDKYFHSNDNPIIAGALLGVGIVNCGIKNDC-----DPALALLGDYIDKEDSSVRIGAIMGLGIS---YAGSQNDQVLIRNKLSPILNDAKAPLDVIAFASLSLGMIYVGSCNEEV---------------AQSIIFALMDRSEAELGDALT-KQESVEATAEVSKTFNEKIRKYCDMTLLSCAYAGTGNVLKVQDLLAQCGEHLEKGDIHQGPAVLGLAMVAMSEELGVDMEIRSLERM------LQYGEQNIRRAVPLALGLLCISNPK------VTVMDTLSRLSHDTDS-EVAMSAIISLGLIGAGTNNA------RIAGMLRNLSSYYYKDMSLLFCVRIAQGLV.............................................................................................................................................................. 753
51 -12.300[S] KOG2611 Neurochondrin/leucine-rich protein (Neurochondrin)  ali follow..  10  2....................................TDVPEPVRKCASLLKGTKSDTE--KFAALFMVTKLVKGKDCNAAGKKLLFEAIGFPFLKKLLVSKDLPNDCPPLVYKSVALSILTCFCQEATHKDIIDAIPTLLEIVEDYEDNLIVVSEAYSCLKSIASH-EPGQQALLATGAIPKMSQIYSAQSFQTDEALHLIVLLVKQFG-VVSWPEDPTAFHALIQRIALDMETDDTERKYELCRILADILITCRREIQIWPESLFKGCGDILKAKIGPKQRDPALHLIATTLHV---GAIEVRMQMDEKKLETTFKQAELLTCCFSILEHCIEYMATDQLDLEPKE-ALKGAFNQVLAVLTRVSDKKFVFAIVKVLSAWLAQETTAMRPAIYKLLPFMLKVANESFQEDVLRIMLPALCHFAVEEEARFTHKQDEVLLESLEFYRPPIPRAERLKRMNEPDPVPTPEQQAEMKVARSAIVALCNILMNFTVLEPKKAEDGPTFANLLKFVVENLPELKDTPDNLVIHGNLAVLGLLSKKVKQNDFSICRYIQATIRFLWDAYNIDESNDPTALVVSIASDLSELWFLGMQTMCGVLPLV---------PWLSEFAL---------ESGWAEGIVKTLKKVIGTLPANVKSAYEDFLSQLVDV............................................................................................................................................................................................................................. 691
52 -12.100[G] KOG2175 Protein predicted to be involved in carbohydrate metabolism  ali follow..  8  138.ELNKLEEIADLVTSVLSSPIRREKLALALENE-------GYIKKLLQLFQACENLENTEGLHHLIIRGILFLNKATL----------FEVMFSDECIMDVVGCLEYDPALAQPKRSELRQKIHQTYRVQYIQDIILPTPSVFEENF-TSFIFFNKVEIVSMLQED----------EKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTAFFKTLAKLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQNVVIEQMICDTDPELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNF------FYNHCMHVLTAPLLTNTSEDKCEKDFFLKHYRYSWSFICTPSHSHSHSQLLALILELLTFCVEHHTYHIKNYIMN------------------KDLLRRVLVLMNSKHTFLALCALRFMRRIIEFYNRYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESIEYVQTFKGLKTKYEQEKDRQ...................................................................................................................................................................................................................................................................................................................................................................... 686
53 -11.700[S] KOG2969 Uncharacterized conserved protein  ali follow..  8  1MDAAFQHNVSGFLVNAKQTD--------NCLNDFKPLKWQTCAVYTSLF----------VCRSSCCRSEQEMEVEVGDPAKASNLLRLIKQLLLEKAYDGVRMLFQSAQESEKNTR----------LPHIAM-DLYHDVCLENISDEQEPELFDCSDELLKLLAKYAPL-------HELMLELMERLEESSSINVF-GAYLRALQVVLQRQGR--DKPQAVEWSLNSIFTHLKDEAQARLIEQNEQVEDLLAHY-ITVGLFREPLRDEILQQDVRTPSQIFRDCGVNRRNIFTCFFIQLLGRPLALLEMNHAKEDLTRSYVQQVTESLTQDANQFMSCQNVFLIEEKLPLHAVAMYYHSLFVGNQLPTNAPKVVYLAEVLLRQQEPPLQYCGLRLVEHHLSTLQHSVPTSSLQRFCEALCKIVYSPQVALRQLGIHVLRQFVLAFDDHGK----YLILKNLMGTLQHG------GLMGYLGGMYKDLVDKALGQSGPMPEVYSGKLFREMLLLCVCVLPHDVKSDLLLHSDRLCHALNIL-KNDVTGFWQALPEIEKELLDPLGTALNFSMAHYKAYKERVEKGQSASDDELMQRQLNMLAVNISNSGMAGGDA--SKLPDIGRQEKLDVLASSITSLETL-----QSLYLRAREIIEQSARLREAGGGGGLGAKGSESTGPEDDAKQAKVDAIRAKILDAALQHVPQQGWTRQAIILGAEESGYPSVVHGALVSHFNGKCNAQLVESLQQKTDGGKQEVEDPLDFLVQAVRQRL------------------EMVTPYKTHWPQAM-ALLAQPQHAPTALAQVLTLVDDICYYSGDRSVDYTRRVGLATIMKMTLQDKSPGHAQTWEFLKSRMDEAVQ..... 936
54 -11.600[O] COG5021 Ubiquitin-protein ligase  ali follow..  9  4................................................................................................FTRCEKARKEKLAAGYKPLVDYLIDCDTPTFLEQEWDDLYVWI----------------ILDRMDGLLLKVAEKYKYKQDPKKECEVKLVEMEAHDV-----DYCLKMLKFTRRLLLNTENRFVYSSG-DVLMYLLNCPNFTIKLAVMRILAILGERFVIAREKIVATLKLALSLSSSVMDEDGEHFSLVDLYFDKKKVPQKWRKLRFTHYTSNDFKKSSQQKNNINETQTSIKKV------------TTQELCEHSLQQIFDKGMALLPAESWFDFSIKASSDDSGENIDLRNTKLNAIAFVNTIFSPPQVSSKLPYAFNSLTDLISLSETELRTDALFTLSDIIRNLGGNISHGLLFQILRYIAKTLREATDEIDEEYNVRFFYLISNLADV-------KPLHESLFA--AGLIPTLLEIVSIRNCPYKRTLASATHLLETFIDNSETTTE--FTMLITSVANEIDFTLAHPETWQPPKYSVVYYSISFRELAYIRSLLKLVGDRIRNLIDSPILVSLKKILENKLVFGLTLITYTLDVVQKVINSEPTIYPVLVEALIPYVIDNFPKLPSAELLSLLPDVVSAICLNPEGLKQVKEKGLINNLFDFLLDADHARILTGDRSTEYGTDIDELARHYPDLKANIVEALCNVIRKMPSRNEREFLFTSPKDQKYFFHRKNEEILTDKEEHEPAYWELLDKGTMLDTFTSVLFGMSLGNGSFSQVPQH-ARDFLAIIFMPPYEYFTSVAISNVTEVLQYLDEKYEDYAFMDVMKVLNDQLENLNDFLNS 820
55 -11.200[DK] COG5103 Cell division control protein, negative regulator of transcription  ali follow..  6  418.......ELVQILLR-LLSEVVTYETSLFLNFLDEKVSAELLLLGTLQL--PLAWNPVQESLAFQWCSDFFSNF-KEHKFVFVRIERT----NPQFLFAFLRSLWLKDSSSVNQVVEFIIENIAALAAARKALSFQDWLDKKMLEFEDADGLNVFLVEVLDFLMSRAALQKNESEQKDTVNVLLTTLMDNVSISEEVSEHIKDVQILCLQVYPRLFSLGHDRDSIVIATNTTNSFSPDVESEVESYFQALYERRIS-----IGKIVLTLQNFKKSENPRDLDLFACLQHSLFDEYR----------------------------------------------PDYPLEALALTAVLFGSLIQELLSFVPLGVALRYVYQALLMPDSKMFRFGMQALVQFQEKLPKPSLQLVRPDIYDSIREMIASNENTEVEKDKLDSFSALANPASPKAPEYTFVSIHVPPLNVPNAEGEIEESVCDNILFAINNLSQLNFNEKLKDVKDNLTPAYLPWFSHYIVTQRVSREANFLSLYGKFLEELKS---------SDLYKIVFRDTLQAILDIMNNNAETLSPSEKTNLKNL-------LGSITLL--------------------------RNKPITTLQVSFKDLLLEGIDSG----IDRVLPFVCKVLEKASSSVIFK-----------------NPWLMGILKLLVELYQFADFRLNLKFEIELLLNNLNVKMDNKPKPAIKNITQLIIQ----------QSVLEIISAVVRRSVGIAAITTKSLLQKDFAAESNPSRLLLAARQMAKTLAGNLAMVTCREPLQMLMINNFRTIALQ-DVENVHAAVAQAIDELVSQNLFVASSVIESVAS-AIAEIDAEIEHMIVE 1267
56 -11.200[R] KOG1877 Putative transmembrane protein cmp44E  ali follow..  7  1..........................................................MSAVSGVISRQVLPV--RARSRQPVKRYKKL---------AEIFPRNQEEGINDRKIGKLCEYAAKNAVRMPKFFQISDSLEHRCYKENENFHSAKIAMCIYRRLLVTCKEQI--PLFSSGFLRTVQALLDQTRQDEMQIVGCQSLFEFVINQLCQLGLEGG------------DDRSRSLRAAGLQALSAMIMGEYSHIPSEFDNVLLGFRVPIYSDLLSFIEINW-----FVVSNNRQSEKHSVGDKVVSAVLENYGHPKILTNANDSGRKWVDEVLKNEGHVAYEDSLINVPSWRTVVNDKGQRTHFLLSMLIKHLDHKSVLKHPSMQLNILEVTSSLSETAKVEHIVSAISDIMRHLRKCMHNCIRMVSVAVDKCLVQLTKKAFPE-------ALFHQLLQAMVHPDHKTRIGAHRIFSVVLVPTSVCPRPSSTTTDLKKGMGLPRSLSRTASVFSSSAALFEKKDKFSSMLTSDHSQNGMPEEERGSSTGEILDRLKSSYRQAYSTWNLNGTLEFYIYDVVHIRLSSHQIGLLLSSITPDNYEAIANTYSLVLLFSRVKNSSHDALIR-QMALSLRDISLMEGGPLPPSRRRSLFTLAASM-------LFSSKAFNLFSLADFTKVTLQGPRLDPFLNLVDDHKLKAVCEKDDASALDTLSNIALSTEHSRGTLVYEIVKSLEDMCNSEMDKMREQ............................................................................................................................. 753
57 -10.700[R] COG5307 SEC7 domain proteins  ali follow..  8  754IDKTTLGDYISVMHEFIDINLKFVDALRRLLQCFRLPGEAQKIDRIMLKFSENADTAYILAYSIILLKNKMTKEDFIKNNRGINDGADLDEDYLGFVYDDILKAMKDDQELAAIAPLMNNFSTSSGFTIQASEEMANKATSVLKKLLYQQKHGSQKTNVYYNATHFEHIGPMLEATWMPILAALSNPLQNSDYVNELNMCLDGFQLVVR-IACLFDLDLIRDAFIKTLTNFTTSEIKLRNTMVIKTLLRIASTEGNNLKDSWKDILTIISQLNVNIGSSNSIRHVSGSTSRSTRTRSLSKPLSPEAVSELMRIFTQTSSLSGSAIVSFFKALCEVSWDEITSSSDLEQPRLYSLQKLVEISIRVEWSSIWNVLGRFFNMVGSDENRHVAVFALDSLRQLSEIEELSLFSFQKEFLKPFEYVMASDTVVEVKELVLQCVKQMIQAKISKI-KSGWKTLFGVFTFAAKARSEILISMTFDTLVNLFSEHYDTLMQQNCLIDMLISFTELIREVYSSLSTMIKEGLSSDLEVRSRALQNLFYIFLEESDDFTEETWEVVKFIFPIFSIFGPEADEATVMLRDEEIRTWQSTTLVEALRSLVTLLTRRFDKLHNLLKGYLWLFSNCICRDNITLSRIGTNCMQQLLSGNAYRFEV-FIELFKETTPHQLLLLETFSNGQGAPVYSENENTQLSHKRGGSLPLISIVAELLDNEEVFNHIPHEHVLKITVAIYDS--QFARKFNEDKSLRITLLNVGFMKQLPNLLRQETASALLYITLLFRLLRDPLGKTETDQKIHKLLFPVCAEMLDMYASLVVEKHTRNHAAWQIATILDSILNLPLELFSENIHTFSCCSMIA--KENLDDQLRELLKNYFNRVGHI....... 1813
58 -10.700[Z] KOG2053 Mitochondrial inheritance and actin cytoskeleton organization protein  ali follow..  8  1............MAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSAQDENLSKTMFLPLAERMVEKMVKE---------DKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSE-KLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWSPPAEEKAVKFIEDRIT--EESKSSRHLRGPHLAKLELIRRLRSQGCNDEYKLGDPEELMFQYFKK-----KPCCFTDLKVFVDLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQQHLCVVQLTRLLGLYHTMDK-----NQKLSVVRELMLRYQHGLEFGKTCLKTELQFSDYYCLLAVHALIDVWRETGDETTVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLY--------------SSLDAKHIQHDTIGYLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKY-------------------------FEKIPE-FIAFRNRLNNSLHFAQVRTERMLLDLLLEANI--STSLAESIKSMNLRPEEDDIPWEDLRDNRDLNVFFSWDPKDRDVSEEH-KKLSLEEETLWLRIRSLTLRLISGLPSLNHPVEPKNSEKTAENGVSSRIDILRLLLQQLEATLETGKRFIEKDIQYPFLGPVPTRMGGFFNSGCSQCQISSFYLVNDIYELDTSGLEDTMEIQERIENSFKSLLDQLKDVFSKCKGDLLEVKDGNLKTHPTLLENLV-SVILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTG-------LQTLISNVVDHIKGLETHLIAILEDTSLSPEERKFSKTVQGKVQSSYLHSLLEMGELLKKRLE. 845
59 -10.700[U] COG5173 Exocyst complex subunit SEC6  ali follow..  8  1MSSDPLQQVCDLIKG------------DLSLERVRD------------------------------IKEQLLKEKS-----------VVEYQLNKESDKYYLKLLNLSKNSVTSIKQQINEV------------------NKLGNDNRFAINRYDILFRATKLYETVNTTSSIYDRIYNFVALMEHIERLLVAELAEDALETGCPHLLEIHFLLTSARDFQEQVVVMAKE-ATEDAQRTVMKLFSRLSGIISKFDKLLDGLTYDIVE-----MARAEQISLAIRLFKIYDL--EREDLRIEAIRNIIKKKEIEIEKSSIKKLPNSKNTARLQDETPKVIEYPTNKGLYQEIMSGTISTRTAPRGYKHFLINGINNSISEMFGEMREKYVGDQKFDVLDNMD-----WIFNELIIVKEHIANCCPPHWNIFEVYFDQYYKELHSLITDLVESEPETIIILDILAFDKTFQDTLKQDF-SEVKSVIGDKEKETLFKDYLNLIVVKMTEWIGNLEKACFQMFTQQVEVAAGTNQAKI--LVGVVERFSDLLTKRQKNWISKISEEIKKQINYNHKYDIDPESIEYLIAVSNDQMKAADYAVAISSKYGKLVSKVYEKQITNHLEGTLDGFAEVAQCSSLG---LITLMFDDLRKPYQEIFS---TWYMGSQAQQIADTLDEYLLDIKPQMNSVIDNVIGETIIKFLTALSFEHSFKNKNNKFLEAMKRDFEIFYQLFVKVLDTVMEFFMDLSCEPIDSILDIWQKYLEVYWDSRIDLLVGILKCRKDVSSSER----------KKIVQQATEMLHEYRRNMEANGV--TLMRRFVLEFEKQ.............................................. 805
60 -10.600[S] KOG3682 Predicted membrane protein (associated with esophageal cancer in humans)  ali follow..  9  1MGSEMSEKVRTRLEELDDFEEGSQKELLNLTQQDYVNRIEELNQSLKDAWASDQKVKALKIVIQCLVYERIFSMCVDSRSVLPDHFENANDTAKETCLNWFFKIASIRELIPRFYVEASILKCNKFLSKTGISECLPRLTCMIGDPLVSVYARAYLCRVGMEVAPHLKETLNKNFFD--FLLTFKQIHGDTVQNQLLPSYLPLYPPAMDWIFQCISYHAPEALLTEMMERCKKLGNNAL------LLNSVMSAFREFIATRSMDFIGMIKECDESGFPKHLLFRSLGLNLALADPPESDRLQILNEAWKVITKLKNPQDYIN------------------------------CAEVWVEYTCKHFTKREVNTVLADVIKHMTPDR------------------AFEDSYPQLQLIIKKVIAHFHDFSVLF---SVEKFLPFLDMFQKESVRVEVCKCIMDAFIK-HQQEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRML-----SYLINGFIKMVSFGRDFEQQLS------FYVESRSMFCNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAFVRACVAYCFITIPSL-----AGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPS--ESFLLEFLCN---------FFSTLLIVPDHPEHGVLFLVRELLNVI-QDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKV---------DSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQ-----SSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTM-VKTLEYIKKQSKQPDMTHLTELALRLPLQTR......... 823
61 -10.500[S] KOG2734 Uncharacterized conserved protein  ali follow..  10  101LDEQSLKKLILVFEKRNLKNQEMRIKFADSPEKFMDSELHTVIQELKGVATVPDLYPILVDLHGLSLLELLAHQNTDIAVAVVDLLQEVTDV----------DILGESQEGAESLIEALRKEQICAL-------LVQNLERLNEQVKEEADGVHNTLAIVENLTEIDSEFVKEAAEQGLLAWLLKRLRGKSPFDPNKLYCSEILSILIQTENENRLLLGSLDGVDVLLQQLASNEEQEYMQNLFNCLCSALMARENRDRFLSGEGLQLMNLMLREKKMSNGSLKVLDHAMAGQDGRDNCNKFVE-----------------ILGLRTIFPLFMKTPKRNKQRLISADEHEEHVTSVIASMLRNCKGTHRQRMLAKFTENDHEKVD-KEIDQQAKDPTIDEDEEAENNYIKRLTQRIDYILLEVSATGDTVKQRVLQILNL------RGASMKTIRSIMREYAGNLGDGDTDWREQEQNHILSLVDR.............................................................................................................................................................................................................................................................................................................................................................................................................. 580
62 -10.300[U] KOG2347 Sec5 subunit of exocyst complex  ali follow..  6  178......TSFEQLKMAVTNLKRQANKKSEG-SLAYVKGGLSTFF----------EAQDALSAIHQKLEADGTEKVEGSMTQKLENVLNRASNTA-----DTLFQEVLGRKDKADSTRNALNVLQRFKF------NLPLNIERNIQKGDYDVVIND-------------AKSLFGKTEVQVFKKYYA---------EVETRIEALRELLLDKLLETPSTLHDQKRYIRYLSDLHASGDP---------AWQCIGAQHKWILQLMHSCKEGYVKDLKGNPGLHSPMLDLD---------------------------------NDTRPSVLGHLSQTASLKRGSSFQSGRDDTWRYKTPHRVAFVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQIERSKNVRQRQNDFKKMIQEVMHSLVKLTRGALLPLSIRDGEAKQYGGWEVKCELSGQWLAHAIQTVRL-----------THESLTALEIPNDLLQTIQDLILDLRVRCVMATLQHTAEEIKRAEKEDWIVDNEGLTSLPCQFEQC---IVCSLQSLKGVLECKPGEASVFQQPKTQEEVCQLSINIMQVFIYCLEQLSTKPDADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCY--------LERHTFLNIAEHFEKHNFQGIEKITQVSMASLKELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDC--------LPPTGVRNYLKEALVNIIAVHAEVFTISKELVPRVLSKVIEAVSEELSRLMQCVSSFSKNGALQARLEICALRDTVAVYL-----TPESKSSFKQALEALPQLSSG---------DKKLLEELLNKFKSSMHLQL..................... 911
63 -10.200[S] KOG4814 Uncharacterized conserved protein  ali follow..  9  91.SEQSIQRLIMMNMRIGKEDAGNFLIADECFQAAV-----ASLEQLYVKLIQRSSPEADLTMEKITVESDHFR------YQAESAVAQGDFQRASMCVLQCKDMLMRLPQMTSSLHHLCYNFGVETQKNNKYEESSFWLSQSIGKMDKKSTGPEMLAKVLRLLATNYLDWDDTKYYDKALN-AVNLANKEHLSSPGLFLKMKILEELLEAVMEILHLDMPLDFCLNIAKLLMDHERESVGFHFLTIIHERFKS-----SENIGKVLILHTDMLLQRKEELLAKEKIEEIFLAHQTGRQLTAESMNWLHNILWRQAASSFEVQNYTDALYYYSLRFYSTDEMDLDFTKLQRNMAAKEAVAEAERHDPRNVFTQFY-IFKIAVIEGN---SERALQAIITLENILTDEAERGSPTMLLSLAAQFALENGQ--QIVAEKALEYLAQHSEDQEQVLTAVKCLLRFLLPKIAEMPESEDKK-KEMDRLLTCLNRAFVKLSQPFGEEALSLESRANEAQWFRKTLAVQCDKDPVMMREFFILSYKMSQFCPSDQVILIARKTCLLMAVAVDLEQGRKASTAFEQTMFLSRALEEIQTCNDIHNFLKQTGTFSNDSCEKLLLLYEFEVRAKLNDPLLESKTFETIAIIAMEKPAHYPLIALKALKKALLLYKKEEPIDISQYSKCM---VPDGASNVELCPLEEVWGYFEDALSHISRTKDYPEMEILWLMVKSWNTGASAEKWCGLALR-FLNHLTSFKESYETQMNMLYSQLVEALSNNKGPVFH........................................................................................................ 908
64 -10.200[J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis  ali follow..  7  54VNVDHVSELETRGLLLLKEDSERFSETLGHGTADKR--------MLQTLISSGTTSDRISALTLLVQESPIHA---------------------KALETLLSICSKKSRNEATQAITTLKDLFIGGLLPDR----LKYMKQQSCLGSKNVTDKHLMVWAF--------ESFLKSFYFKYIQIIEALS--FDALLFVKSQMVSTIYDLLK------AKPEQEQNLLKLLINKLGDKENKIASKASYSILQLEASHPAMITKEIERFIFTLNQTVLTHKQVDVANLLIEIYFVFFTKLLFALEKEEVADAPTLEK-----------------------KSLQSDSKNKKSQKRKKDEDLRKEAEENVNSRVISAVLTGVNRAYHTASFNTSVQVLMLIFQASASRDFIS-----DRYYKSLYESLLDPRLTTSSKQSLYLNLLYKSLIIDNNIPRVRAFIKRMVQVSAWQQPPLVTGLFHVMHQLVIA.............................................................................................................................................................................................................................................................................................................................................................................................................. 502
65 -10.000[R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  9  1MKKK----------STDLYGRKNPGMQSMSGSFSSLQIALDESSSNFSTIYEPPDLSGLDAEMIVIVKNLQKR----------------DIVTKCRALQDLIQWNDPSQFDNEQFLNA-------------LAVLFPRLS--------------------------------------------------EVERHVRLKIFVFMSVLSSALQKKLA--PWLKFYITPWVMGFFDSDRAVSVSAKDSFKNLLEKWPHVWLKFGSTIAPIVTDVFLHEDKE-----------SLTDLRFFSNEEAESKVTRVKSSCLLTLSF-----------LFKQTADLENLETDKKIDKQTFKSSLYENLSTLFKSDEF--------SLVSSPQDGVTVSLSDLLLIILK--DKPFVTQYKEKYFKRVSRMISRLTSLTCVPMLRLLSNMISNFPNNDSKRPLSKLFSNLITKRISLPNSG---FYTSLLNLFKSIGAMQLVPS---------IESVDELCDAFLETANQEQRFLSTEVYDCLNFLSFVYTDSSDPQIKDHDRLRTIFTRYFKGEFVLRCSTSDFDHLQSVFDKNSDFASLWNEVLFGFFNDESMDIETIPFDSLSRNLSLTVQTVLYLKNRNFQTGNEVMSILGPCLSFLMKLSTHKNERIACLSASQLITVCHIFSDTTLIKPVKELFQKYLVNDLPSSILKLGPQSPAFTLLRDILLLLKD-YADLSEPWENVANQFTVVLNSLPSLFADGKLRGKISLVKTLVEYYDTAVFAIMQNPGNDWDMIRACIGS-EETIKNILFTTLEYFLTNDWVDNHLIILCASLHSLKAHLPTIFDENKSLYSLLPVILFSKPEDDGHVAAHFESIFSLLKEKALEDSG. 776
66 -10.000[A] KOG1104 Nuclear cap-binding complex, subunit NCBP1/CBP80  ali follow..  8  5...................................................................RAHDTEDEGYDHRRNKRRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLEADLGTFR-LKILRILSDCAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKT-FKESLKMCRWDAARYSLRFLALQLLDTMIDVSNEDTVPQVRRDWFVFAVLSTLPWVGRDLYEKKESALESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQ------EYLDCLWA-QIRKLRQDNWAEKHIPRPYLVFDSILCEALQHNLPTIVPPPHHDNFEYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLEHLHHIIETYHHERKDCA-AQLLSFPYKHKIPLEYCIVEVVFAELFHMPTPRYLDICYGSI--LIELCK-LQPATLPQVLAQATEILFMRIDSMNTSCFDRFVNWFSYHLSNFK----DSCLLLDGEHPRPKFIQEVLQKCLRLS-------------------------------YHQRITEMMPTTYAKLIPLTPVANEEAANLPGTTVAHQLVVAIR------QKCTPEEVVNILKDIPNSGYSGEEMSDGSFNALKIDVFVQTLLNLGSKSFSHSFAAISKFHSVFRAAETEEAQICILHNIFELWSSHQQMMVVLIDKLLKVATWIFSKEMTGEFTKLYLWEILHLTIKKMNKHVIKLLSEAKEKLAKADSSSSDSEDDSSHKRKKPITHADKPSEEVVERMEEKLEAANVNQKRLFLIVFQRFIMILSEHLLRSDTDQQVFLMHHEQVQKYSSTLETLLFTSDLDTHILEVFQQFVA........................... 797
67 -9.940[Z] KOG2842 Interferon-related protein PC4 like  ali follow..  11  20.SEDESFDNVSVYSH--MSEVASSEATDELANERFEEKFEKALEQA------TEKSAQTRVQALQAICELLMHR------------PDFVEDRKMTLMDFVEKSIRRGKGQEQVWGARLAPLLVLQMGGDESKAMNQFLLNTVQDKSVGFDARAKCCTAVGLLS-GCEDVGELVHLMQSFEAIFAGVSVTAEAGTFHAEALNAWGLLLTLIPSLMTTGQNMFPSIKKFLGLLQSTHLDVRMAAGETIALILESDIAELSEAVKQLATDSHKYRAKRDRKAQRATFRDVLRYLEV.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 323
68 -9.890[T] KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  6  1.................................................................MIKQIFGKLPRKPSKSSHNDSNPNGEGGPSSKSSASNSNGANGTVIAPSSTSSNRTNSFRDVPTSEKPNLFIKKLSMCSKNLREKEIKRQTLLELVDYIATVSTKLSDAAMQEIAKVAVVNLFRTFPSANHESKILQVVYELLLRFDAKLAKRYIDHSFVLKLLDLFDSEDQREREYLKTILHRIYGKFMVHRPFIRKAINNIFYRFIFETEKHNGIAELLEILGSIINGFALPLKEEHKLFLIRALIPLHRPKCASAYHQQLSYCIVQFVEKD---------------------------FKLADTVIRGLLKYWPVTNSSKEVMFLGELEEVLEATQAAEFQRCMVPLFRQIARCLNSSHFQVAERALFLWNNIRNLITQN--HKVIMPIVFPAMERNTRGNQAVQSLTLNVRKVMAET----------------------QILFDECLAKFQEDEANETEVVAKREATWKLLEELAASKSVSNEAVLVPRFSSSVTLATGKTSGS....................................................................................................................................................................................................................................................................................................................... 506
69 -9.830[S] KOG4346 Uncharacterized conserved protein  ali follow..  8  29....LLRQWLKSLHFVLQCDDNREYFDLEPYSWLLSQYDVSTLESLLRVLKDYAVAPRGRKVVHTILKELDPAACLKTAQSALSAGLNLYVLETPHWKHCLLQKLPLQRTPVDNKQLITLASYLNAVAPAQLQVLLNQLLGIWSKRI----LQKLGSQ-------------EHLAISKLLVLAAKCLCGNLMDLNIQRQLHDGLSNHLQSPDALQRH-----KTVELIFNFIALPDAKEDDRLRFEYDSFKDTFHWHIFEEFDELGQFESPSKTKLDEKPCEDQL---------KQLELHLSDFMSTTEQKEPHKPNIEIQANPAPENQNVNMQLDSDDDEPLDEDDDELKPYDMSNDTTTTIDQRPKFVIDLLHLLRE--KVENYQVFEGALGTAEQLIRGQLAKHDTQLALDLLQLFLVMEMEQFERTQFKCCVAIGPCAEYLCRQFHTDNSFYSASVILQVLAATAKELSVDVIPPAAKHPRKFEFQQEEESPAARLAAAQRIIRDRLRAKTKRYFSKPKAGDQMEKANPFHPVAGTF-------------FFSLVRGQRTRQMLYVKYENISHDIDTQ--LLVNLLNTMSVLVMCSQNC--PLLPAMTREIFDLCAFVRFNAEARVRAATLQLIGIALVTLAQHFAESLNELQRWLNDFIRSETSEECRELAQSILDTCYKLFDT................................................................................................................................................................................................... 712
70 -9.500[D] KOG2168 Cullins  ali follow..  9  1MDTEGFGELLQQAEQLAAEGISELPHVERNLQEIQQAG-----ERLRSRTLTRTSQETADVKASVLLGSR-RLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWEQVKQRILHTLLASGEGRSSLDNIEMAYARQIYIYNEKIVNGHLQPNLVDLCASVAELDDKS---SDMWTMVKQMTDVLLTPATDALKNRSSVEVRMEFVRQALAYLEQSYKNYTLVTVFGNLHQAQPGTYQLVRSFLNIKLPAPLPGLQDGEVEVWALI-LAASQVVNRAQHQLGEFKTWFQEYMNSKDRRLSPATENKLRLHYRRALRNNTDPYKR-----AVYCIIGRCDVTDNQSEVADKTEDYL---------LKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGESHFTVNQQPFLYFQVL-------FLTAQFEAAVAFLFRMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCLRRLNRLLMLYTRKFESTDPRELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQI-KERLKNMALSIAERYRAQGISANKFVDSTFYLLLD-LITFFDEYHSGHIDRAFDIIERLKLVPLNQESVEERVAAFRNFSDEIRHNLSEVLLATMNILRVIEDRDSQLRSQARTLITFAGMIPYRTSGDTNARLVQMEVLMN...................................................................................................................................... 819
71 -9.280[U] KOG1107 Membrane coat complex Retromer, subunit VPS35  ali follow..  8  1MPTTQQSEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMAISDELHYTDEFAKGRKVADLYELVQYAGNIIPRLYLDILKDLVEMCRGVQHPLRGLFLRNY-------LLQCTRNILPDEGEPTDEETTG-DSMDFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQ-IVLTGILEQVVNCRDALAQEYLMECIIQVFPD--EFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPGIPAD-----------------IKLFDIFSQQVATVIQSRQDMPSEDVVSL---QVSLINLAMKCYPDRVVDKVLETTVEIFNKLN-------------LEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFD-------YESRKSMSCYVLSNVLDYNTEIVSDQVDSIMNLVSTLIQDQPDQPVEDPDPEDFAD-EQSLVGRFIHLLRSEDPDQQ------YLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQLITLIIGTFMKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQ--VQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEE-----TEQINKHFHNTLEHLRLRRESPESEGPIYEGL............................................................ 794
72 -9.220[S] KOG3695 Uncharacterized conserved protein  ali follow..  7  1........MFSKFTSILQHAVEALAPSLPLQEDFVYH------KAITHYYIETSDDKHLEQMLDILVQEENERESG-----------ETGPCMEYLLHHKILETL--------------YTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLHLSTSLDNLSVTSLPEASVVCPNQDYNLVNSLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCL----------TQSTCLCELLTDRLSLYKALPQSVDPLDIETVEAINWGLDSYSHKEDASAFPGKRALISFLSWFDYCDQ--------IKEAQKTAAVALAKAVHERF---FIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVL---LQEMVFFILGEQREPETLAEISR--------------------HPLRHRLIEHCDHISDEISIMTLRMFEHLLQKPNEHI----------------LYNLVLRNLEERNYTEYKPLCPEDKDVVENGLIAGAVDLEEDPLFTDISPENTLPNQEWLSSSPPATPDHPKNDGKTEVHKIVNSFLCLVPDDAKSSYHVEGTGYDTYLRDAHRQFRDYCAICLRWEWPGSPKALEKCNLEAAFFEGHFLKVLFDRMGRDQPYDVNLQVTSVLSRLSLFPHPHIHEYL----------LDPYVNLAPGCRSLFSVIVRVVGDLMQDFTPKLLLVRKRLLGLEPEGPIIDHITLLEGV--VLEEFCKELAAIA......................................................................................................... 755
73 -9.180[K] KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA)  ali follow..  10  5................................................................................................................................................................................................................................................................................................................................................................PKETVEVIAQSIGITNLLPEAALMLAPDV---EYRVREIMQEAIKCMRHSKRTTLTASDVDGALNLIYGFASGGPFRFRKAI-----DFKDVIEAPLPKAPLDTEIVCHWLAIEGVQPAIPENAPLEVIR-QKDGPLIDVRLPVKHVLSRELQLYFQKIAELAM------SKSNPPLYKEALVSLAS---------DSGLHPLVPYFTNFIADEVSNG-------------------------------------------------------NDFRLLFNLMHIVRSLLQNPHIHIEPYLHQLMPSVVTCLFADNHWELRDFAANLVSLICKRYGTVYITLQSRLTRTLVNALLDPKKALTQHYGAIQGLAALHTVVRLLILSNLEPYLSLLEPELNAEKQKNQMKIYEA-WRVYGALLRAAGLCIHGRLKIFPPLPSPSPSFLHKGKGKGKIISTDPHKRKLSVDSSEN............................................................. 432
74 -9.160[DT] COG5261 Protein involved in regulation of cellular morphogenesis/cytokinesis  ali follow..  8  717...MTVKNFVHLLD-----DTNFDFEEEVLLEKMRKE-------IVQQVRDNEEIEVHINELIALLVKNKISLDDVLKHHNKYKFGKQSTEYLKINTLS--MKSLNNSSRKFLELYQCFFYVLQTN------EMYLANYFQALKTEGTSSVKIRHAVYLVLQIFGHGSNRREEVLLLRFISQVIKLEAALVNSSQDLLSDDCVWKLLFTGYRGDVREVKLWKTILRIHKVLVADNHLDFEINPLTLFKSFNP------------------EVASQTDSPKLTLSLAMQHPPTRNLYVSRLRELRKLCQSFLVALSKNIENIPYALCYTAAQLKNSLQRYFPAAHKEE-------------IFGVIGKFVY---WAYVAPVLVSPD-ALQRKNLYTLSSILSEIFSIELSEFIEVSKQDTMLMLKRPVIYMKRDDILGIYSSIAYVIDSIAPPDVNDPLRAVVNSLGPVSEQDNDFVQDETDVKLELNPKFCTIENPVAQERTLIVQTKRYILFIIRI-------------QNGLNLLEILVKPVTDSDEAAWQNLLAEESEKNARNYDLFDDSIFSMSFAELKYTALSNIVEMEKLGFANRRNNYQDMVNSIALDIRNKSRRRMQRQRELDHQSLLNLREKRAFLDSQYNEYIEQAMETLQSKKGKKKLIPFSKQYFHMRDLRKSGRVPRFGSFKYPALKLYDRGVLVSISHMPQKEKLYITISILEATSPTVKVSSPRCELH-LDDLLSAQYNKVLTLDV-LDGRLKLNTNMFLHLIFSKF...................................................................................................... 1487
75 -9.150[UZ] KOG1961 Vacuolar sorting protein VPS52/suppressor of actin Sac2  ali follow..  8  1MAEVPSPQMTEQLDNEEVRERQYSRQIEKEFKEVENKSIEDYIANLHNQI--NDCDDVLERMENMLFQSVLNNISTEITQLQRKS-VSMSLQLTN--RQSVKAQLSQFIEDMAVSEEMINIIMETPVTERDFSTQLNVLNHKLSLVKELSFKESKSTSDVSDVLQKLRLKAMAK-IRSYLLEQIYKFRKPMTNYQIPQNAMLKHKFFFEFILSN---------------------ERHVAQEICSEYIDTMG---KIYYSYFKSYSTRLTSLKFEESCTKDDLMGIEDNASKGLFSKTTSLKHKSTIFTIGKRGDILNQQLEAPIIVP------------HAQLKNRYTAEALFRSEQYALVDNACRE-----YLFVTEFFMVRGTQAQDL-------------NQIMGKTLTLMIKNLETSIHDCFDTIAMFLCIHLIFRYQLMCHKRCVPALDKYWDSLQAVIWPRFELV-------FRLNIQSIHDCDPTKFNKELGPHYITRRYAEFSAAIVGISEHFPNELVELQNEVECFILRMAAIFPTRKDQYLINNYDLVLGVLMEHTRDNSKEAEAFR------------EQLNSRSAEYVEEILAPHFGGIIQFVKECEHFFEKEQMDELRKQERRSLALVASFSANWKKSLEELNREVLLSFPSLL----------TGSQLLQLALASLVQYYHRFHKLLTPNARAQLTN----------IHVVMVEIKKYKSNY................................................................................................................................................... 662
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.