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Query: [C] KOG1257 NADP+-dependent malic enzyme, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITELast
1 -150.000[C] KOG1257 NADP+-dependent malic enzyme  ali  100  1MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE 584
2 -80.400[C] COG0281 Malic enzyme  ali follow..  18  1.....................................................................................MTEQLRQAALDFHEFPIP----GKIEVTPTKSLATQRDLALAYSPGVAEPCLEIEKDPAASYKYTARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGINV---------------------------FDIEVNEHDPDKLVDIIASLEPTF-GGVNLEDIKAPECFYIEQKLRERMNIPVFHDDQHGTAIISAAAIINSLRIVGKKIEDVRLVASGAGAASIACLNLLLSLG--------MKRENITVCDSKGVVYKGRDDKMDQTKKEYA-----IEDNGWRKLADAIPNADIFLGCSAAGALTQDMVKSM---AAHPIILALANPNPEITPPEAKAVRPDA--------------IVCTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKRAAVYAIADLALEEQNGADYVIPRPFDPR-LIVRIAPAVAKAAMESGVATRPIQNWD---AYVEKLTQFVYKTSL.................. 429
3 -6.870[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  172........................................................................................................................................................................................................AFLGMLREVLAAEP--------------GKWGKIAEAVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTRHSLIDGIN---RATDMLMGGKNVLVCGYGDVGKGCAEAFDGQGA-----------RVKVTEADPI-------------NALQALMDGYSVVTVDEAIE--DADIVITATGNKDIISFEQMLKMK---DHALLGNIGHFDNEIDMHSLLHRDDVTRTTI---KPQVDEFTFSTGRSIIVLSEGRLLNL---------GNATGHPSFVMSNSFADQTIAQIELFQNEGQYENEVYRLPKVLDEKVARIHVEALGGQLTELTKEQAEYIGVDVAGPFKPEHYRY................... 478
4 -6.690[E] KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases  ali follow..  11  43........................................................................PGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIE-GYRAQHSQHRTPCKGGITDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINP-------KNYTENELEKITRRFTMELAKKIGPGVDVPAPDMNTGE---IADTYASTIGHYDINAHACVTISQGGIHGRISATGPGFRDKTFVVQGFGNVGLHSMRYLHRFGAK--IAVGESDGSIW--NPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEV-----DCDILIPAATEKQLTKSNAPRVKA----KIIAEGAN-TPEADKIFLERNILVIPDLYLNAGSYFEWLKNLNHVSYGRLTFKYER----PTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIKVFKVYSEAGVT............................................ 556
5 -6.550[E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase  ali follow..  13  10..................................................................................................................STQGIIKEALHKLGFDEGMYDLIKEPLRMLQVRIPVRMDDGTVKTFT-GYRAQHNDAVGPTKGGVPDVDEEEVKALSMWMTLKCGIVNLPYGGGKGGIVCDP-------RQMSIHEVERLSRGYVRAISQFVGPNKDIPAPDVFTQIMAWMMDEYSALDKFNSPGFRSTALGVVIAIEQAAKRRNMQIEGAKVVIQGFGNAGSFLAKFLYDLGAK--VGISDAYGALH--DPNGLDIDYLLDRRDSFGTVTNLFEETISNKELFEL-----DCDILVPAAISNQITEDNAHDIKA----SIVVEAANGPTTPEA---------------------TRILTERGILLVPDVLASA--------GVTVSSEEEVNEKLREKLEAAFDTIYELSQNRK-------IDMRLAAYIIGIRTAEAARYRGWA............................................ 414
6 -5.920[P] COG2072 Predicted flavoprotein involved in K+ transport  ali follow..  2.......................................................................................................................................................NQHFDVLII--GAGLSGIGTACHVTAEFPDKTIALLERLGGTWDLFRYPVRSDSDMFTFGYKFRP-YIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDY-NYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAG-------SNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVYEFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNGAASVVTDQIETFTEKGILCKSGREADIIVTATG-----------LNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTVATPRDAQDCALDVG............................. 434
7 -5.840[V] COG1002 Type II restriction enzyme, methylase subunits  ali follow..  11  1.................................MDKSAEFSNKVRNKL-YYGIFPKEIHSVEEHPSVFNSKIKNQRSQLVKQIKEKGMEEVTYTWFNRLVALKFMEMNGCLQDQIKVFTSTDPNKPEPDLLTNALKLDFLNLNRDLVLDLKAENKDEELYKYL--------ILKLCNYLNKIMPFLFEKIEDYTELLFPDKLLHTGSVLHDLNSIIPDEDWQEVEIIGWIYQDYIAPKKDKVFADLKKNIKISKENIPAVTQL-FTPHWIVRYLVENS-VDLMEYYVKPEQQETDFLKINSPEELKICACGSGHMLVYAFDLLYAIYEEEGYTPSEIPEIILTHNLFGIEIDKRAGELAGFALTMKARGKDRHFFKHRATLLQFAEADNFGSLIRPAAMEVSGLLSLLESKNLSGNLSHLSTHQKVLQALKQADYLSPKYHVVIANPPYMGNKGMNNNNYADVKSDLFSAFIVRNTELAFPKLGFMSPFMFISSYEKLRDFLINEKTITSLIQLEYSGFDGATVPICTFTSENAYHPEFKGGYVRLSDFRG................................. 591
8 -5.820[E] COG0169 Shikimate 5-dehydrogenase  ali follow..  14  1...............................................................................................................................................................MASQIDQYAV------GNPINHSKSFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDD--------------GEILGDNTDGEG--------LVQDLLAQQVLLKGATILLIGAGGAARGVLKPLL----------DQQPASITVTNR-----------TFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCY--------------DMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESF................................................................................................................... 253
9 -5.720[GM] COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component  ali follow..  72...............................................................................................................................................................GYKGEIL---GIIGSNGA----GKTTLCKMLSGIYVDGRVSALFSLGTGRENAYLNGMMLGIEKDQID-QFIDEIHESFIDQPMKYYSSGMKARL-------GFSVAAFLEPEILILDEALKAKMVILVTHSLRYAR----KNCDRLLWLDRGEIRAIGEPAEVIEKY-KETIPVKVRRPRKRLELKKTEANVKERTVVKAENIGMSFNFKNETFWALKNVSFDIKEGEVVGIIGHNGAGKSTLCKLLTKILTEGELELSGETTSLLSYGTGFNAQLSGKDNVYLNGM-----LLGIPKERVAQEYPNIVAFSELE---MDKPVKSYSSGMKSRLGFSIAATLQPDIFIIDEAL....................................................................... 441
10 -5.660[R] COG5322 Predicted dehydrogenase  ali follow..  11  90....................................................................................................................................................................................................................................RAIAQRVVDAVESLKDQGAQVVGLGFTAIVGNRGLQTLERTGIPVTTGNS----TAYAAYRNVLESMDRLGVEPADTEVAVVGYGSIALVIAKLLAGHGCR-------------------LCLVHRGSEAQGRQGLAYLPEPMHAQVRLSNDIEHCYEHFYVAATSTGGLIDPYRLR------PGSVVVDAALPRD-------KPYRKDRNDILIIDGGLVSASSALRFGAESMGLAPKKFLNGCLAETLILGEAFSIGRELPEDKVLEIGRIAELHGFSPSPMASYGEPVKDRHFAALRPFHRPRTQS............................................... 373

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24