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Query: [M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MESCFPAMKLNQCTFGLNNEIVSERVSAFWGTQVVKPNHLRTTKLRSAPQKKIQTNLIRSVLTPFVDQESHEPLLRTQNADPKNVASIILGGGAGTRLFPLTSKRAKPAVPIGGCYRLIDIPMSNCINSGIRKIFILTQFNSFSLNRHLSRTYNFGNGVNFGDGFVEVLAATQTSGDAGKKWFQGTADAVRQFIWVFEDAKTKNVEHVLILSGDHLYRMDYMNFVQKHIESNADITVSCLPMDESRASDFGLLKIDQSGKIIQFSEKPKGDDLKAMQVDTSILGLPPKEAAESPYIASMGVYVFRKEVLLKLLRSSYPTSNDFGSEIIPLAVGEHNVQAFLFNDYWEDIGTIGSFFDANLALTEQPPKFQFYDQKTPFFTSPRFLPPTKVDKCRILDSIVSHGCFLRECSVQHSIVGIRSRLESGVELQDTMMMGADFYQTEAEIASLLAEGKVPVGVGQNTKIKNCIIDKNAKIGKNVVIANADGVEEGDRPEEGFHIRSGITVVLKNATIRDGLHILast
1 -138.000[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali  100  1MESCFPAMKLNQCTFGLNNEIVSERVSAFWGTQVVKPNHLRTTKLRSAPQKKIQTNLIRSVLTPFVDQESHEPLLRTQNADPKNVASIILGGGAGTRLFPLTSKRAKPAVPIGGCYRLIDIPMSNCINSGIRKIFILTQFNSFSLNRHLSRTYNFGNGVNFGDGFVEVLAATQTSGDAGKKWFQGTADAVRQFIWVFEDAKTKNVEHVLILSGDHLYRMDYMNFVQKHIESNADITVSCLPMDESRASDFGLLKIDQSGKIIQFSEKPKGDDLKAMQVDTSILGLPPKEAAESPYIASMGVYVFRKEVLLKLLRSSYPTSNDFGSEIIPLAVGEHNVQAFLFNDYWEDIGTIGSFFDANLALTEQPPKFQFYDQKTPFFTSPRFLPPTKVDKCRILDSIVSHGCFLRECSVQHSIVGIRSRLESGVELQDTMMMGADFYQTEAEIASLLAEGKVPVGVGQNTKIKNCIIDKNAKIGKNVVIANADGVEEGDRPEEGFHIRSGITVVLKNATIRDGLHI 518
2 -95.600[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  27  6....................................................................NSSIVKLPNKYELVKDTLVLILAGGRGSRLYELTDKRAKPALYFGGNRRIIDFALSNCLNSGLNRIGVVTQYAAHSLLRHLQNGWSFLPAERGEFIDMLPARQQI----DDSTWYRGTADAVYQNMAIIR--DHYCPKYILILAGDHIYKQDYSQMLLDHIHSGAKCTVGCIEVEREKATEFGVMAVNENLKVKSFVEKPKDPPA--------------MVGKPNTSLASMGIYVFDADYLYDVLEREVSTSHDFGKDILPKALEEGVLYAHPFEIYWRDVGTLDSFWQSNIDLVCENPQLDIYDQSWPIRGNPVQTYPSKFNARPVDNSLISGGCVITDASISYSVLFDRIKINEGSQIDHCVVLPQVTIGKNCKLKRCIIDRHSVIPDGMEIGVDLELDRQRFRVSSGGVV----------------LVTPSMLKKLNGEEVASEAHL 438
3 -71.100[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  19  1....................................................................................MRAVLMAGGSGTRLRPLTCDLPKPMVPILNR-PIAEHIINLLKRHHITEVIATLHYLPDVLRDYFQDGGDFGVQ-------MTYAVEEDQP--------LGTAGCVKNIAELLD-------ETFLVISGDSITDFDLGEAIAFHKQKQSKATLILTRV--PNPIEFGVVITDEAGKIKRFLEKPSTSEIFS-------------------DTVNTGTYILEPEVLEYLPSN---TECDFSKDLFPLLLAKDPMYGYVAEGYWCDVGHLDAYREAQYDGLDRKVKLDF--AYRENSPGLWIGQNTYIDPSAHIEAPAVIGNNCRIGA-AGTVIGDNVTIGADANLKRPIVWNGAIIGEEAQLSACVISRGTRVDRRAHVL-EASVVGSLSTVGEEAQISPGVRVWPSKKIESGAILNINLI.............. 375
4 -67.800[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  16  3..............................................................................SSMEEKVVAVIMVGGKGTRFRPLSLNIPKPLFPIAGQ-PMVHHPISACKRIPLAQIYLVGFYEEREFALYVSAISN--------KVPVRYLREDKPH---------GSAGGLYHFRNLI---MEDSPSHIFLLNCDVCCSFPLPKMLEAHRGYGGIGTLLVIKVSPESASQFGELVADVTNELLHYTEKPE---------------------TFVSDRINCGVYVFTPEIFNAIGDVSTTDFVRLDQDILSPLAGKKRLYTYETMDFWEQIKSPGMSLRCSGLYLSQFRLTSPQ-ASGDGTRSAIVIGDVYIHPSAKVHPTAKIGP--------NVSISANARVGPGVRLMSCIILDDVEIMENAVVTNAIVGWKSSIGRWSRVQAEGTILGDSVAVEDEVVVTSSI-VLPNKTLNVS--VQDEIIL............. 415
5 -54.500[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  12  1............................................................MASRKKRAAKISEDSEEEQSRRQRLQAILLADSFATKLLPLTLERPNVLLPLVNI-PMIDYTLAWLESAGIEEVFVFCSMQVIDYLNNSDWYSHKDFT-------VKTIESPQNS---------TSAGDALRYIYEQQIETSQIQGDFVLVNGCIVSNMPLTQLIQEHRDRKKKDEKAIMTMVIRNPLTKQLLYYDEDNICFSLLDRNPSVLLCSD-------------------MQDCYIDICSLEVLSLFVDN-QHMRCDFVEGVLADDIIGYKIFHEISSCYASRIENFRSYDMVSKDIIQRRTFPYVPDMKFSERQGIYKASDATQLPSAHVGASYVIGHATNIGKILNSVIGNGCSIGSNVVIQGSYIWNNVTVEDGCEIRNAIVCDEVKVCAGAIVK-PGVVLSFKVVVGRDFVVPAYSQVSLLRQPMEEDSDEENLL.............. 435
6 -54.400[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  19  1.................................................................................MKMRKGIILAGGSGTRLYPVTMAVSKQLLPIYDK-PMIYYPLSTLMLAGIRDILIISPQDTPRFQQLLGDGSQWGLN-------LQYKVQPSPD---------GLAQAFIIGEEFIG-----GDDCALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHV--NDPERYGVVEFDKNGTAISLEEKPL---------------------EPKSNYAVTGLYFYDNDVVQMAKNLKPSARGELETDINRIYLEQGRSVAMMGRGYWLDTGTHQSLIEASNFIATIEERQGL----------------------------------KVSCPEEIAFRKGFIDVEQVRKLAVPLIKNNYGQYLYKMTKDS...................................................................... 292
7 -53.400[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  12  4.................................................YEHAALPLASSPSILGPISGGRNRGNIQLQSIPIEFQAVVFAGF-GNSLYPLTGSDPKALLPIGNK-PMLHYPLYWLEAAGFTSAILICMEEAEAHINAWLRSGY------------EGHMRIHVEAPTILDDSKSSADALRAVSHLIKSLTDTHQNDFVCLSCDSIVGLPPIYGLDKFRLDNPSALAVYSPVQSKEIDAKQLIGIEEKTSRLLYAKSSADVGSDFTFRMSLLWKHPRV--TLNTNLSDAHIFVFKHWVIDLIREK--ESISSIRGDLIPYLVKCQQKSFTVRENIQRFLSSPNNIDNYDGGLSSQEIKINALIAKDGIICPEQRLVDVTVSERALVGADCMVNEGTTIKNIKKSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLESCIVASGAQI--GAKSKLRECEIGVDHRVEAGRIA-RGERLVDMEKIET....................... 465
8 -44.000[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  19  2................................................................................RKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDK-PAIQYIVEEAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKG-EMQQIADLANIHYIRQKEPLGLGHAVLCAEHFI------GDEPFAVLLGDDIMVSELRQLMDVYDVYGTEV-VGVQSVLPEDVSKYGIINTSGSQEVNDLVEKPSPEEAPS-------------------EIAVMGRYVLNSSIFSVLKTIGRGAGNEIQTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEMR.................................................................................................................................................... 277
9 -36.100[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  13  1....................................................................................MKAIILAAGLGTRLRPMTENTPKALVQVNQK-PLIEYQIEFLKEKGINDIIIIVGYLKEQFDYLKEK-----------GVRLVFNDKYADY---------NNFYSLYLVKEELA-------NSYVIDADNYLFKNMFRNDLTRS---------TYFSVYREDCTNEWFLVYGDDYKVQDIIVDSK------------------------AGRILSGVSFWDAPTAEKIVSVSGEFVDLYWDNMVKDNIKELDVYVEELEGSIYEIDSVQDYRKLEEILKNEN........................................................................................................................................................ 229
10 -34.500[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  15  1....................................................................................MEAVILAAGFGSRLGHHTREIPKALLKIGKR-PLIYYTVQTLMENGIRDVVVVTGHKGYVLREYLSQFD---------NFKFVHNSLYKKT---------NNIYSLYLAMDHVS-------KGFYILNSDVLFHPGI--FRELHSSTKENLILSVDTF--KELGEEEMKVKIEDGVVKRISKQLNPSEADG---------------------EYIGIARVEENIIDDLYNHERKGRRVFYEEAFQSMMDDGAVYYETTKGLWIEIDTPADLMKARYEIYPK......................................................................................................................................................... 238
11 -28.400[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  13  2................................................................................PQNTLNIVILAAGKGTRMY---SKMPKVLHEIGGE-TMLGRVIDTAAALNPQNICVVVGHGKEQVLDTVKRDVVWVEQTEQ----------------------LGTGHAVKTALPHLA-----AEGRTLVLYGDVIDVETLETLLEAAGNEVGLLTDVP-----ADPSGLGRIIRDSSGSVTAIVEEKD-----------------ADAAQKAVKEINTGILVLPNAKLEAWLNSLSSNNAQYLTDLIAKAVADGKIHPVQVRSSHLAAGQAQELLKAGVTLRDPARFDVVIDVNCIFEGKIELGDNVEIGANCVIKNAKIGANSKIAPFSPQAKLADDVHVGNFVEIKNAAIGKGTKANHLTYIGDAEVGSKTNFGAGTGVHKHKTVIGDEVRIGSNCVLVSPVKIGNKVTTGAGSTITRNV............... 430
12 -16.700[M] COG0836 Mannose-1-phosphate guanylyltransferase  ali follow..  13  1.............................................................................MNEQSRKITPVLLAGGAGSRLWPVSRDLPKQFQPLVGNLSTYQQTLKRVGDSLYSEPLVITNEDFRFF-----------ARRQAEEIDLPATVVLEPAR-------RDSAAAM--AAAAVLAERREPGCLVLALAADHVVL-KFSEAVKLGAKAADQGNIVVFGLPTEPRTSYGYIKPGDA-TVDAFVEKPDVTTAISYLEKGYL---------------NSGNFLFRSDVMIAELKAFAPEILAAVTQAVEQYESDLGFVRLHQASFWSDIGSWDAIWEIA---------------------------------DKHDNDNALEGDGVFIDS-EGCLIHSTQLLTTVVGAKDLVVVAT.................................................................................. 330
13 -15.600[G] KOG2638 UDP-glucose pyrophosphorylase  ali follow..  7  102..............................................................................SSVLNKLVVVKLNGGLGTSMG----KGPKSLIGVRNENTFLDLTVQQIENTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLRPVAKDVSHGDIYASFYNSGLLDTFIGEGKEYIFVSNIDNLGAT-LNHLINPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKA-------------HVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNAKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHL---TVSGDVTFGKNVSLKGTVINHGDRIDIPPGAVLENKIVSGNLRILDH........................................ 508
14 -14.500[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  15  1.................................................................................MTNFTVIIPARYASTRL-------GKPLAEIAGK-PMIAHVFEKAMQSGAKRVIVATD--HEQVATVARG-----------GAEVCMTSETHQSGTE-------------RLAEVVEKLGIAEDEIIVNIQGDEIPPAIVRQVAENLAKYQVKMASLAVNITDPEELF---VLTDHAGYVLYFSRAPIPWHRDQFASLPKEKSTRGQLVLSDHYLRHIGIYAYRAGFIKQYIQWQPSVLEQIESEQLRVLWYGEKIHVELAREV-EDLEKVRSILE................................................................................................................................................................. 257
15 -12.300[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  17  1....................................................................................MLTLLMCGGKGTRLG----RGEKPLFEVCGM-KLIDHSLLQYKDF---DVIAITSPHTPATESYLAEKGVEVYRAA-----------------------KGYIEDYSEACRELA-----INEPVIVASADIIRDIAFDIVDAYMKTIKPALTVVM....................................................................................................................................................................................................................................................................................... 122
16 -11.900[Z] KOG3121 Dynactin, subunit p25  ali follow..  12  1..........................................................................................................................................................................................................................................................................................................................................................................MEIPDTYYSKDEYVETASGNKVSRHTVLCGSQNIGKVIVQSGAIIRGDLANVRTGRYCVIGKNSVIRPP----YKQFSKGIAFFPMHVGEHVFV--GEGAVVSAATIGSYVYIGKNAIIGRRCVLKDCCVIEDGAVLPPETTVSSYMRYTARGTIE 153
17 -11.500[E] COG2171 Tetrahydrodipicolinate N-succinyltransferase  ali follow..  16  107...........................................................................................................................................................................................................................................................................................................................................................................................................................PPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTAQIGKNVHLSGGVGIQANPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIGQST............... 212
18 -11.000[G] COG4284 UDP-glucose pyrophosphorylase  ali follow..  12  97.............................................................................EAIGKGEVAVILMAGGQGTRLG---SSQPKGCYDIGSKKSLFQIQAEKLIKVEIPWYIMTSGPTRAATEAYFQEHNYFGLNKE--QITFFNQGTLPAFDLTGKHFLNGGLYRAIKENKLNEDFDRRGIKHVYMYCVDNLSKIADPVFIGFAIKHGFELATKAVRKRDAHESVGLIATKNEKPCVIEYSEISN-----------ELAEAKDKDGLLKLRAGNIVNHYYLVDLLKRDLDQWCEN--------MPYHIAKKKIPAYDSVT--PNGIKLEQFIFDVFDTVPLNKFGCLEVDRCKEFSPLKNGPGSKNDNPETSRLAYLK-------LGTSWLEDAGAIVKDGVLVE-KLSYAGENLSQ............................................................................. 462
19 -10.800[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  14  1.........................................................................MTTPIAKSTRRIVAVVPAAGIGSRMQ---MDKPKQYLHIHGK-TILEHTLSVLLGYPIEKIILAVAANDPYISTCPLLTHP--IQLVEGG--------------------SSRADSVLNGLNAVKSAVQNSEDFWVMVHDAALTHQDLDKLVQVEDQNGAILAIPATDT---------IKRALHNQQIHYTEDRSQLWLAQTPQ-------------------------FFPIATLAQALEQALAQGLQVTDEA--SAMEFAGFRPHLVAGRSDNI......................................................................................................................................................................... 219
20 -10.500[M] KOG2388 UDP-N-acetylglucosamine pyrophosphorylase  ali follow..  8  110.................................................................FGTDNFIEMEKRGVVEARNAAFVLVAGGLGERLG---YNGIKVALPRETGTCFLQHYIESILERDIPFIIMTSDDTHSRTLDLLELNSYFGMKPT--QVHLLKQEKVACLDDNDARLADFSSMLVAATQLLCLKVFIQFLMEIHNSLMTSLVQAI--ASLGVSATKQYHVNSLAVPRKAKEAIGGISKLTHVDGRNVEYNQLDPLLRASGFPDGDV-----NCETGFSPFPGNINQLILELGPYKDELQKT--------GGAIKEFVNPKYKDS---KTAFKSSTRLECMMQDYPKTLPPTARVGFTV----MDIWLAYAPVKNNPEDAAKVPKGNPYHSATSGEMAIYRANSLILQKAGVKVEEPITWKPKWGMIFSDIKKKV-SGNCEVSQRSTMAIKGRVFIKDLSLDGALIV----------DSIDDAEVKLGGLIKNNGWTMES.... 571
21 -10.200[R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily  ali follow..  15  10............................................................................................................................................................................................................................................................................................................................................................................................IPVVHPDAFVHPSAVLIGDVIVGLASLRGDYGRLILEAGSNLQDGCIMHDTIVHENGHIGHGAILHGCVVGRDALVGMNS-VIMDGAVIGEESIVAAMSFVKAGFQGEARQ........................... 131
22 -9.770[R] COG2068 Uncharacterized MobA-related protein  ali follow..  12  3............................................................................LPAKSRLKVGIVLLAAGRSSRMG----GPNKLLALFDGK-PLVRRTAERALGSKASGTIVVTGHQRERVRAALSG---------------------DVTFADNPDFANGLSTSLKAGIAYL----PEDTAGAMIVLGDMVVSGDLDRLIDAFRKAGGNSVVRASPVLLPRALFPAIAHLEGDTGARHLVEAEGLDVVDVEIGEGASVDVDTREA.................................................................................................................................................................................................................................... 196
23 -9.600[M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog  ali follow..  14  1.................................................................................MNDILFIIQARMGSTRL-------GKVLRPLGSN-RLLDILVHRVRQSARDNLVIATSDKETD-------------------------ILEAHCIKQGFRVFRGSEERVLD--RFVKVIEAVKPSVIIRLTGDFVDPELLDVMIQAHFDQGSDYTYILN------------APLGICGEVVNA---------------NLLIDISRIQALEDQYQEHVTLYIRNHPALYRVQFLEAPERFRAPQDTKEDYESIKALYQKAGERPDVSASELITLLNRNPDAAT.......................................................................................................................................................... 235
24 -9.550[M] COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase  ali follow..  10  1..................................................................................................................................................................................................................................................................................................................................................................................MIDKSAFIHPTAIVEDGAVIGANAHIGPFCIVGPQVEIGENGQTKIGRDNEIYQFASIGEVEIGDRNRIRESVTIHRGTVQGGGLTKVGSDNLLMINAVAHDCTVGNRCILANNATLAGHVSVDDFAII-GGMTAVHQFCIIGAHVMV 171
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;