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Query: [IE] KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGNKSGEVLLVTGGSGFLGQHLIKQLLERKEELGIKEIRSLDIVPYKNNIGHEETSLLRTYVADIGGDLKALSPIFNGVDGVFHCAASVKIEYPPNYEELERVNVNGTLAVVDLCIQNNVKRLVYTSCTSVCFVPFKGRSTFSAVINSTESKTDTPTLDSSTLWEQDNQFLIPGYASSKLRAENIVLNSNGAPLHNQKEYLATSAMRAPLTYGECDSHFITEIFDFLSTRGWVFPRIAGVGGKQQLVYAGNVAWGHICAYKALKVSDKAVNGLPVFVTDDTGINDVSRFVQKMAVLGERFKVKTSWWYVPHFLFFFLAFLLEVVVRVAYPYTKYRLRYSLRAIASYTSSMLMYNRLRASIHMDYMPLFDPDASAERSAKWYATWWDQRQQAQKLKKSSLast
1 -105.000[IE] KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases  ali  100  1MGNKSGEVLLVTGGSGFLGQHLIKQLLERKEELGIKEIRSLDIVPYKNNIGHEETSLLRTYVADIGGDLKALSPIFNGVDGVFHCAASVKIEYPPNYEELERVNVNGTLAVVDLCIQNNVKRLVYTSCTSVCFVPFKGRSTFSAVINSTESKTDTPTLDSSTLWEQDNQFLIPGYASSKLRAENIVLNSNGAPLHNQKEYLATSAMRAPLTYGECDSHFITEIFDFLSTRGWVFPRIAGVGGKQQLVYAGNVAWGHICAYKALKVSDKAVNGLPVFVTDDTGINDVSRFVQKMAVLGERFKVKTSWWYVPHFLFFFLAFLLEVVVRVAYPYTKYRLRYSLRAIASYTSSMLMYNRLRASIHMDYMPLFDPDASAERSAKWYATWWDQRQQAQKLKKSS 398
2 -53.000[C] KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit  ali follow..  16  63RSSVSGIVATVFGATGFLGRYLVQQLAKMGSQVLVPFRGSEDSPRHLKLMGDL----QVVPMKFDPRDEDSIKAVMAKANVVINLIGREY---ETRNFSFEDANHHIAEKLALVCEHGGIMRYIQVSCLGASVSSP------------------------------------SRMLRAKAAAEEAVLNA----------LPEATIMRPATMIGTED-RILNPWSMFVKK--YGFLPLIGGGTTKYPVYVVDVAAAIVAALKD----DGSSMGKTYELGGPDVFT----THELAEIMYDMIREWPRYVKLPFPIAKAMAAPRDFMVNKVPFPLPSPQIFNLDQINALTTDTLVSDNALKFQDLDLVPH-KLKGYPVEFLIQYRKGGPNFGSTVSEKIPT 396
3 -50.100[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  14  31.LANLPPLVTVFGGSGFVGRHVVRMLAKRGYRIRVAVRRPDLAGFLQPL-----NVGQISFAQANLRYRDSIIKAVEDADHVVNCVGILA---ESGRNTFDAVQEFGAKAIAEAARDTGA-TLTHISAIGADANSQ------------------------------------TGYGRTKGRAEAAIHSV----------LPGAVILRPSIIFGPEDDFF--NKFAKMARNLPFLPLIGGGKTKFQPVYVEDVAEAVARSVD-----GKLKPGAIYELGGPDVMT----FRDCLEAVLAATYRERSFVNLPFGVASMIGKLASLV--------PLITPPLTPDQVTMLKKDNVVSAEAEKKGLTLEGIVRVASVLPSYMVQYRQHGQFSNAGKAA.... 354
4 -48.800[MG] COG0451 Nucleoside-diphosphate-sugar epimerases  ali follow..  14  1......MRYLVTGTAGFIGFYVAKRLLDAGHFVTGFDTKYYDVSLKEKRHAILARSNGFRAEIGMLEDTDALKRAAEAPEIIIHLAAQAGVRYSENPRAYIDSNLIGSFNMLELARSLKVKHLMLASTSSIYGANEKIPFAESD----------------------KADEPMTLYAATKKSMELMAHSYAHL-------KLPTTAFRFFTVYGPGRPDMAPIKFVDAVSNGQPIDIYGQGNMSRDFTYIDDLVEGIVRLSAVIPSEEHHAPFRVVNIGGGQPVE----LMHFVETIEKAVGKPAIRNMLPM------------------------------------VPRTFASPDLLRALTGYVPQTPVEEGIKALVAWYRGINGNLTE........ 339
5 -48.100[M] COG1088 dTDP-D-glucose 4,6-dehydratase  ali follow..  15  2......RKILITGGAGFIGSALVRYIINETSD-AVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDICDRAELARVFTQPDCVMHLAAESHVDRSDGPAAFIETNIVGTYTLLEAARAKSAFRFHHISTDEVYGDLHS---------------------TDDFFTETTPYAPSSPYSASKASSDHLVRAWLRT-------GLPTLITNCSNNYGPYHEKLIPLMILNALA-GKPLPVYGNGQQIRDWLYVEDHARALYCVATTGKV------GETYNIGGHNERKNLDVVETICELLEELAPNKPQGVVHYRDLITFVA-----------------------------DLRYAIDASKIARELGWLPQETFESGMRKTVQWYLANESWRKQVQDGSYQG 348
6 -45.100[GM] KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase  ali follow..  16  28...QSNMRILVTGGAGFIGSHLVDKLMQEKNEVIVADNYFTGSKDNLKKW--------IGHPRFELIRHDVTEPLFVEVDQIYHLACPASPFYKYNPVKTIKTNVIGTLNMLGLAKRVGA-RILLTSTSEVYGD------------------PLVHPQTESYWGNVNPIGVRSCYDEGKRVAETLMFDYH------RQHGIEIRIARIFNTYGPRDGRVVSNFIAQALR-GEALTVQKPGTQTRSFCYVSDMVEGLMRLMEG--------QTGPINIGNPGEFT----MVELAETVKELIKPDVEIKMVEN-------------------------------------RQRKPDISKAKEVLGWEPKVKLREGLPLMEEDFRLRLGVPKK........ 343
7 -44.000[M] COG1087 UDP-glucose 4-epimerase  ali follow..  17  1......MTILVTGGAGYIGSHTCVQLIEAGHEVVVVD-NFDNSHPEALHRIEKITGRAPRREPGDIRDRALMEQMIKKCTAVIHFAGLKAVESSEKPLLYYDCNVLGTLRLLQAMEATGVKKLVFSSSATVYGDP-----------------------DKLPITEDQPLSATNPYGRTKLVIEDMLRD-----LYNSDNSWAIAILRYFNPVGAHESNLMPIIAQVATGRREKLNIWGDGTGVRDYIHVNDLAAGHLKALKKLDKPK----CFAVNLGTGQGYS----VLDVIKAFEHVSNREIKYEIAPRRPGDVAECYA--------------------------------DPGFAKKFLGWSAEKNLREMCQDMWNWQSKN.............. 330
8 -43.800[GO] KOG1431 GDP-L-fucose synthetase  ali follow..  13  1MGEPGSMRILVTGGSGLVGKAIQK-VVADGAGLPGED------------------WVFVSSKDADLTDTAQTRALFEKPTHVIHLAAMVGFRNIKYNLDFWRKNVHMNDNVLHSAFEVGARKVVSCLSTCIFPDKTT-------------------PIDETMIHNGPPHNSNFGYSYAKRMIDVQNRAYF------QQYGCTFTAVIPTNVFGPHDNHVLPGLIHKVKSSGSALTVWGTGNPRRQFIYSLDLAQLFIWVLRE----YNEVEPIILSVGEEDEVS----IKEAAEAVVEAMDFHGEVTFDTT------------------------------------QFKKTASNSKLRTYLPDFRFTPFKQAVKETCAWFTDNYEQARK........ 321
9 -42.900[M] COG1089 GDP-D-mannose dehydratase  ali follow..  12  2.....TKVALITGVTGQDGSYLAEFLLDKGYEVHGIKRRASSFNTER-YQDPHGSNPNFHLHYGDLTDSSNLTRILKEVDEVYNLAAMSHVAVSESPEYTADVDAIGTLRLLEAIRFLGLERFYQASTSELYGL-----------------------VQEIPQKESTPFYPRSPYAVAKLYAYWITVNYRES-------GIYACNGILFNHESPRRTRKITRGLANIAQGLESCLYLGNMDSLRDWGHAKDYVRMQWLMLQQ--------QPEDFVIATGVQYS----VRQFVEMAAAQLGIKMSFVGKGIEEKGIVDSVEGQDAPGVKPGDVIVAVDPRYFRPAEV-DTLLGDPSKANLKLGWRPEITLAEMISEMVAKDLEAAKKHSLLKSHG... 364
10 -41.700[R] KOG4288 Predicted oxidoreductase  ali follow..  16  1......MKIVVLGGSGFLGHNICKLAIAKGYEVVSVSRRGAGGLHNKEPWMDDVE-----ETLDAQKDPNSLLPVLRDASAVVNSVGILEAKQSKNKVTFEAINRDLAIETAKIAAKANVPVYCYVSAHAA------------------------------------APGLDPRYIKTKREAEREISKISN---------LRSIFLRPGFMYNFNDRPFTGALASLFTNRATSGALNFLGTASAEPLPSEEVALAALEAIS-----DPSVKG-PVEISELKSMAH................................................................................................................. 269
11 -41.600[M] KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase  ali follow..  15  89QREEGVTHVLVTGGAGYIGSHAALRLLRDSYRVTIVDLSRGNLGAVKTLQQLFPQTGRLQFIYADLGDPLAVEKIFSAFDAVMHFAAVAYVESTLYPLKYYHNITSNTLGVLEAMARHKVKKLIYSSTCATYGEP-----------------------EKMPITEDTPQVPINPYGKAKKMAEDMILDFSKN------SDMAVMILRYFNVIGSDQGRISGACFDAARGFIPGLQVKGDGTCIRDYIDVTDLVDAHVKALEKAQPRK----VGIYNVGTGKGRS----VKEFVEACKKATGVEIKVDFLPRRPGDYAEVYS--------------------------------DPTKILKDLNWTARFTLQDSLQVAWRWQKIH.............. 429
12 -40.200[V] KOG1502 Flavonol reductase/cinnamoyl-CoA reductase  ali follow..  16  3.NSGEGKVVCVTGASGYIASWLVKFLLSRGYTVKASVRDPSDPKKTQHLVSLEGAKERLHLFKADLLEQGSFDSAIDGCHGVFHTASPFFNDAKDPQAELIDPAVKGTLNVLNSCAKASVKRVVVTSSMAAV------------GYNGKPRTPDVTVDETWFSDPELCEASKMWYVLSKTLAEDAAWKL------AKEKGLDIVTINPAMVIGPLLQPTLNTSAAAILN----------PNLSFGWVNVKDVANAHIQAFEV-----PSANGR-YCLVERV-----------HSEIVNILRELYPNLPLPERCV------------------------------NPYVPTYQVSKDKTR-SLGIDYI-PLKVSIKETVESLKEKG............. 322
13 -39.000[G] KOG0747 Putative NAD+-dependent epimerases  ali follow..  15  1MASYTPKNILITGAAGFIASHVANRLIRSYPDYKIVVLDKLDYCSNLKNLNPSKHSPNFKFVKGDIASADLVNHLLIGIDTIMHFAAQTHVDNSGNSFEFTKNNIYGTHVLLEACKVTGIRRFIHVSTDEVYGETDEDALVGNH--------------------EASQLLPTNPYSATKAGAEMLVMAYGRS-------GLPVITTRGNNVYGPNQEKLIPKFILLAMR-GQVLPIHGDGSNVRSYLYCEDVAEAFEVVLHKGEV------GHVYNIGTKKERRVND--------------------------------VAKDICKLFNMDPEANIKFVDNRPFN--DQRYFLDDQKLKK-LGWSERTTWEEGLKKTMDWYTQN.............. 322
14 -28.900[Q] COG3320 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes  ali follow..  15  4.PGTEVRTVLLTGATGFLGRYLALKWLEREGKVIALVRAKSNEDARARLDKQELATDHLEVIAGDKGDRQTWRRLADTVDLIVDPAALVNHVLP--YSELFGPNTLGTAELIRIALTSKQKPYIYVSTIGVGNQIEPAKFTEDSDIRVISPT------------RNINNNYANGYGNSKWAGEVLLREAHDL------CGLPVTVFRCDMILADTSYAGQLNVPDMFTRMMLSLAATGRQRAHYDGLPVEFIAEAISTLGDQ--SLHDRDGFTTYHVMN--PHDDGIGMDEFVDWLID.................................................................................................... 313
15 -28.400[M] COG1091 dTDP-4-dehydrorhamnose reductase  ali follow..  15  1......MRLAVTGRNGQVVSALQA-LAGADLEIVTLGRPELD-----------------------LVRPENVLQALREADVVVSAAAYTAVKAESEPDIAFAVNRDGAKAVAQAAKELGVP-VIHLSTDYVF--------------DGSKATAYV---------ESDPTGPTSIYGRSKLKGERAVSEATDN----------YVVLRTAWVYSEYGNNFVKTMLKLSESRDEINVV---ADQFGCPTSATDIAAAVVAIARKLVEDSSASLRGIFHLSGTGETTWANFAKQIFAFSAENGGKSMIVNDITTKQYPTPA----------------PRPANSR-----------LNCRKLEEIYGLKLP-SWQTSTREVVTALAQTKKEKS......... 297
16 -24.400[R] COG1090 Predicted nucleoside-diphosphate sugar epimerase  ali follow..  13  28.GRRTLMKIILTGATGFVGCSLVPLLHQQGHELTLLVRSVSKA----QRLFAPGSFPQLKAIAYEATKSGDWQKVVDGQDAVINLAGISERWTEAYKAEIFDSRKLGTEKLVEAIAKADRKPQVMISGSAIGYYGTSETATFTESSKPGDD------------------------------LAEVCQAWENAAHQVEQLGVRLVVFRIGIVLGADGGALAKMLPPFKLFAGGP---LGSGEQWFSWIDRRDLIALIDKALT-----DSTLRG-TYNATAPNPVKMKEFCHTLGKVLARPSWLPVPDIALELLLGEGAKLVLE............................................................................ 308
17 -22.800[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  15  639ILPTNGQYFLLTGATGYFGRRFLEYLVKLNISVVCLVRESSDEAAKERLISLRISSENIIVWAAHVEDDAKWEFLVENVSRIYHMAAEVHW---KSYQELRPANVLGTKTVLELSVMGP-KALYFISGGGQ---------------------------QEVELDDDTQSAKASGYALSKYVAELLCRKISDLGHP------LIYVIRPGFIIANDSRDFFWRFVATALRMGIWPQSDESQSLVFHISTTDALCMTLTQILEK--------ADAYAPLLAYDKFD----GDEFACICESMKNVKLDFVTLEDWLKALEKDVDE............................................................................ 927
18 -22.700[I] KOG1221 Acyl-CoA reductase  ali follow..  20  20....ANKTILITGATGFMGKVLVEKLLRSCADLNYLLIRTKKGVDPSVRKEQYFKCVKVRVVKGDLLSANDTNTLASNVEVVFHCAANVRF--DQPLRPMVMMNVVGTLKVLRLAEKSQLQALVHVSTSYCQCNESVEERAYPAPQNPFSIIEMVETMDDEALAEITPKLL-NTYAYSKALSEDLICRYNN--------KLPIIITRPSIVTGWIEGVNGPTGLMIGAARGVIRSMHCNPDYASTVIPVDKAINGMILCG.......................................................................................................................................... 300
19 -22.400[G] KOG1203 Predicted dehydrogenase  ali follow..  10  118.EMGTSGIILVAGATGGVGRRIVDILRKRGLPVKALVRNEEKAR--------KMLGPEIDLIVADITKENTVPEKFKGVRKVINAVSVIVGPKEGDTPERQKENVSAYDGLELRLKGDGIISLLPLSSIRAYIQDPVTPRFVHVGSAGVTRPERPGLDLSKQPPAVRLNKELDFILTYKLKGEDLIRDS----------GIPFAIVRPCALTEEPAGADL---------------IFEQGDNITGKVSRDEVARICIAALE-----SPYALNKTFEVFKES..................................................................................................................... 545
20 -20.900[R] COG2910 Putative NADH-flavin reductase  ali follow..  13  2......AKIALIGASGNAGSRILKELSDRGHQVTAIARNPEKIAALPN----------VVAKKGDVFDQAALSELLKGHDAVISSVHFTA---------------SDPATLIEAVRASGVQRYLVVGGAGSLEIAPGQRVVDLPDF---------------------PAAYKAEATKGAEFLDKLK----------QEKQLDWTFLSPSAEFVPGERT.................................................................................................................................................................................... 157
21 -20.900[T] KOG4039 Serine/threonine kinase TIP30/CC3  ali follow..  16  239...IKMSSAFVVGATGAVGSELVKLLAESTKFSKVVVLARRPV--------DGATGDKLIQKTVDFDKLEENAEDIQGVDVAFCALGTTR--GKSGADGFYKVDHDYVMSAAKMAKENGVKQFVLVSSVGA------------------------------------DASSRFLYPKTKGEVEKEIGELN-----------KFVIMRPGLIEAKRPE------FRIGEFLGKIVTAPLGLFSNRFSSSATAIAQAMINATQTEETGNQIWNNSKIV.......................................................................................................................... 450
22 -18.500[Q] KOG1204 Predicted dehydrogenase  ali follow..  16  2.....GKVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAG---QSLQREYGADKFVYRVLDITDRSRMEALVEKLDGIVANAGMLEPVKSKQWERLFDVNFFSIVSLVALCLSPFVGNIVFVSSGASVKPYNG----------------------------------WSAYGCSKAALNHFAMDI---ASEEPSDKVRAVCIAP----GVVDTQMQKDIRETLGPQGMTPKALERFTQLYKTSSLLDPKVAAVLAQLVLKGIPDSLNGQYLRYNDE...................................................................................................................... 256
23 -17.100[MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases  ali follow..  13  280....TEKSVMVTGAGGSIGSELCRQILAKPKTLVLFELNEYNLYTIDQELQAIKQNLKLNTALGSVQRENRVKKLMQQVETVYHAAAYKHV--EDNVIEGIRNNVFGTLACANAAIEAGVKNFTLISTDKAV-------------------------------------RPTNIMGASKRMAELVL-----QALADKNSTTIFTMVRFGNVLGSSG-SVVPLFKKQIRAGG---VTVTHPDIIRYFMLIPEAAQLVIQAGAMSH------NGQVFVLDMGEPVKIVDLAKRMIHLMGCDGRSDEGDIEIKFTGLRPGEKLYEELLIGENVEGTSHQKIMTACEEKLSWDAMEDLLTELDVCCHNFDVECIKRILLDAPTGYSPQ.............. 620
24 -16.400[R] COG4221 Short-chain alcohol dehydrogenase of unknown specificity  ali follow..  12  1MSESQGKIAVITGAASGIGLATTEALLEQGATVVMVDWNEKALNDLAAKLGER-----AIPQVTNLLDADSCNAMIPHIDILYCNAGTLTETTPEAIDKMLNLNVNAVQAVVPHMSERKTGDIIVTCSIAGHFPTYWE----------------------------------PVYSGSKWAITSF---VQGMRRQMIPHGVRVAQVSP----GPVVSALLADWPEENLRKAKESGSLIDA---------SEVADAVVYMLT---RKRTVTIRDMLVLPTN...................................................................................................................... 239
25 -16.100[IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  15  1MGKLTGKTALITGASQGIGEGIARVFARHGANLILLDISDEIEKLADE----GGRGHRCTAVKADVRDFASVQAAVARIDILVNNAGVFLDMSEEDRDFHIDINIKGTKAVLPEMIKRKDGRIVMMSSVTGDMVADPGET---------------------------------AYALSKA----IVGLTKSLAVEYAQSGIRVNAICPGYVRTPMAESIARQ--SNPDDPESVLTEMAKAIPLRRLADPLEVGELAAFLAS---DESSYLTGTQNVIDGG...................................................................................................................... 252
26 -15.200[Q] KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)  ali follow..  12  43..SAKGLVAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKRMLVRQGDATRLHFIECDLTDFESVRRAAKEIDILINNAGIMFQ-TKDGHEKTWQSNHLGTELFLPAVKKSSYARIINVSSRI---------------------HLKSEKINLATVDDKKSFGMMKSYRQSKLANVMHARALTKELRKDGAEHVTVNSLHPGVV---------TELARNTILNTPGIKQITAVFRWFLMKTSRDGAQTSIFLA--LGKKIGGISGKYF........................................................................................................................... 300
27 -15.100[I] COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH)  ali follow..  13  1MGFLSGKRILVTGVAS-IAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDI---VLQCDVAEDASIDTMFAKFDGFVHSIGFVNAVTREGFKIAHDISSYSFVAMAKACRSNPGSALLTLSYLGAERAIPN----------------------------------YNVMGLAKASLEANVRYM---ANAMGPEGVRVNAISAGPI---------TLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCS---DLSAGISGEVVHVDGG...................................................................................................................... 250
28 -15.100[R] KOG1611 Predicted short chain-type dehydrogenase  ali follow..  11  1...MSPKSVVVTGSNRGLGFGLVQQFLKDPNVQHVI---ATARDVDKATALKGICDPRLHILQLSLGSDESIANFAEGLTLLINNAAVMLPYVTKVVLDLFESNTIGPMMLIIKASKRQEGDTLSVSRGAIINIASEFLGSISENTSGSGEYKAM------------------AYRMTKCAVNQFTKTLS---IDLKDDHILTAGICPGMV-------------------------MSKGKGQLT---IEESSSQILAAFNKLGATHN---GG-YFRRDLSIIP.................................................................................................................. 250
29 -14.800[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali follow..  14  2..KMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAEAKQQLPN------IHTKQCDVADRSQREALYENLNVLVNNAGIQKEIDFKKDGDEIELNFQASALFTPHLMKQPEAAIVQVTSGLAF----------------------------------NPLAVYPVYCATKAALHSF---SLTLRHHVRDTSVEVIEMAPPMV........................................................................................................................................................................................... 185
30 -14.700[I] KOG1478 3-keto sterol reductase  ali follow..  16  2.....RKVVLITGASSGIGLALCKRLLAEDDELHLC-RNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELDCIYLNAGIMPN-TADGLQEVFETNVFGIRELEPLLCHSD-SQLIWTSSRS-------------------------ARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRN----NQQGLYSNVACPGTA........................................................................................................................................................................................... 226
31 -14.600[R] KOG0725 Reductases with broad range of substrate specificities  ali follow..  8  2......SCALVIGATSTLGKAVVRRLAFTGYKVAAAADCPNSVGKVAEDNIK--VGGDVTAFSLDVANAEHRKELITGLDTLIIVPPQNEVLGEEDFDKLFANNLTTSQAAMSTLAKSQNGSIIYLTSCFGFTPSID----------------------------------MGLYSVASS----VLSLTKSVAQSAAKQGVRVNSVVSGMIEGDGTGAVWDH--ASGEEARQIKQHLESMIPLGRLGRPSDVASYVEFLAS---TKARYITGENCIVGGG...................................................................................................................... 248
32 -14.600[QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases  ali follow..  11  24VSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTL-----DVTKMESIAAATQGLWGLVNNAGILTPITLEDSMNMLKVNLIGVIQVTLSLVRRARGRIVNVSSIL--------------------------------------AFFVGGYCVSKYGVEAF---SDILRREIQHFGVKISIVEP----GYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDCME-LTSVHPRTRY................................................................................................................ 281
33 -14.500[R] COG0300 Short-chain dehydrogenases of various substrate specificities  ali follow..  14  2....RKKTIFITGASSGLGRQLAIDFSWEETVLCLFARSQERLENVQRIVVE--NGGEAHIYPVDLADPQSIDRSFAVVDVLINNAGYFCDSQMDENERMFRVNVFGTAAVLPTMREQGSGHIINIASQA-----------------------------------KIATAKSAIYSATKHAVLGF---TNSLRMELKGTGIHVSAVNPGPI........................................................................................................................................................................................... 185
34 -14.200[Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11  ali follow..  13  47PKSIAGEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQI-QDIYKVRAKAYKANVTNYDDLVELNSPVTVLVNNAGVMMHRDPADVQLMINVNLTSKLVFLPKMKELRKGFIVTISSLAGVFPLPY----------------------------------SATYTTTKSGALAHMRTLRMELDLENQKDIHVTTVLPSFL---------TNSDVTQLTHTIGF------GDVYPLFTGEEVAQRIVAGMVR........................................................................................................................................ 275
35 -14.000[Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases  ali follow..  10  1MESGDESPVLITGSQGGIGHALAREFTEKGCRVVATSRSRSTMTDLEQD--------RLFVKELDVQSDQNVSKVLSKIDVLVNNAGVLAETPISAMENTFNTNVFGNKDLIFSFNYYIYWSFNSSGSMRMT----------QAVVPHMVSKKKGKIVNVGSITVMAPGPWAGVYTATKAAIHAL---TDTLRLELRPFGIDVINVVPGGI........................................................................................................................................................................................... 205
36 -13.500[Q] KOG1210 Predicted 3-ketosphinganine reductase  ali follow..  14  29..ALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHNDKQVVLCISVDVSDYNQVENVIKPVDMLVNCAGMFEDLEVSTFERLMSINYLGSRAVITTMKERRVGRIVFVSSQAGQLG-------------------------------------FTAYSASKFAIRGL---AEALQMEVKPYNVYITVAYPPDT--------TPGFAEENRTKPLETRLISETTSVCK---PEQVAKQIVKDAIQ........................................................................................................................................ 260
37 -13.300[IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases  ali follow..  11  2..DLAGKNVVYLGGFGGIGQKCVQELLQRPIKA-LAIFDLNANEQLLAKWKSQHPDTDVFYHKLDITQKSDIDAAYKHFDVVVNGSGLMN---DRLVELTIQINLLGVINSTLTALEYMDKAIVNISSVAGL----------------------------------QPTAIMAIYSAAKT-GVTTFTRAMANPYFYAHSGVGFLTICP----GFTDTGLLEDIGN--KTTFTYDTPMLAMFNRVKRQKAEDCARNLVSAIETSKNGTQHPDTEIFYQKMD--ITQKSDIDAAYKATAEKLG................................................................................................. 297
38 -12.800[I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase  ali follow..  11  71VQKVESPVVVITGASRGIGKAIALALGKAGCKVLVNYARSAKEAEEVAKQ--EEYGGQAITFGGDVSKATDVDAMMKTIDVVVNNAGITR-MKQSQWDEVIALNLTGVFLCTQG-------RIINISSVVGLIGNIGQ----------------------------------ANYAAAKG----VISFSKTAAREGASRNINVNVVCPGFIASDMTAELGEDMEKKILGT---LGRYGKAEEV-----------AGLVEFLALSPAASYITGQAFTIDGG...................................................................................................................... 305
39 -12.100[Q] KOG1205 Predicted dehydrogenase  ali follow..  12  42SEKVNGKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRC-RKLGSPDVAVVRGDVSVIKDCKRFVQRLDHLVNNAGIADYSEISDVLPIVNTNFWGPVYATHFALKKTKGKIIAVASPAGWSGVPR----------------------------------MSIYAASKA----AMINFYETLRIELHPEVGVTIVFPGLI........................................................................................................................................................................................... 229
40 -11.700[I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3  ali follow..  9  43FLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERT--GRSVKIIQADFTKDDIYEHIKEEIGILVNNVGMHFLNAPDEIQSLIHCNITSTQLILKHMESRQKGLILNISSGIAL----------------------------------FPWPLYSMYSASKAFVCAF---SKALQEEYKAKEVIIQVLTPYAV........................................................................................................................................................................................... 231
41 -11.200[I] COG4982 3-oxoacyl-[acyl-carrier protein] reductase  ali follow..  12  355..LYSSEIAVVTGASGSIAASVAARLLDGGATVIATTSKLDEERITFYRRDHARYGAALWVVAANMASYSDIDALVEWITLLFPFAAPRVIGDGARSEIEMKVLLWAVQRLIVGLSKIGTERLHVVLPGSPNRGMFGGD---------------------------------GAYGEAKSALDAVVSRWHAESS--WAARVSLAHALIGWTRGTGLMGHNDVIVSAVEEAGVT--TYSTDEMAAMLLDLCNAESKVAAAGTPITVD---LTGGLGEVDLDMAELAAKAREDHAAQAAEDEATEASEVAGT---IAALPSPPRGYTPASPHWDDLDVDPADLVVIVGGAEIGPYGSSRTRFEMEVAGELSAAGVLE--LVWTT................ 723
42 -10.900[I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes  ali follow..  14  317IKSLCNKVVVVTGAGGGLGKSHAIWFARYGAKVVVNDIKDPFSVVEEINKLYGEGTAIPDSHDVVTEAPLIIQTAISKVDILVNNAGILR-MKDEEWFAVLKVHLFSTFSLSKAVTKQKSGFIINTTSTSGIYGNFGQAN----------------------------------YAAAKA----ILGFSKTIALEGAKRGIIVNVIAPHAETAMTKTIFSEKELSNHFDASQVSPLV-----------------VLLASEELQKYSGRRVIGQLFEVGGG...................................................................................................................... 554
43 -10.900[S] KOG2733 Uncharacterized membrane protein  ali follow..  13  1MSGDR---VIIFGASGFTGKYTVFEAVTVLRGLRIAGRNREKLEAVLKEMGAKAKKSQVPIFIADVNDQASLLEMAKKCRIVVNTAGPYRFHG---------------ENVVKCCIESGTHHVDVSGEPQYM------------------------------------ETMQLRYDQLAREKGVYVVSACG............................................................................................................................................................................................................... 143
44 -10.800[S] COG3268 Uncharacterized conserved protein  ali follow..  12  1MSPDKREDIVLYGATGFSGKLTAEHLALSESTARLAGRSSERLRNVRALLGPNAQD--WPLIVADASQPSTLEAMAGRAQVVLTTVGPYTRYG---------------LPLVAACARTGTDYADLTGELMFC------------------------------------RNSIDLHHKQAAATGARIILACG............................................................................................................................................................................................................... 141
45 -9.510[C] KOG1494 NAD-dependent malate dehydrogenase  ali follow..  10  25.GSVPERKVAILGAAGGIGQPLALLMKLNP---LVSSLSLYDIAN-TPGVAADVGHINTRSEVVGYMGDDNLAKALEGADLVIIPAGVPRKPG-MTRDDLFNINAGIVKNLCTAIAKYCPHALINMISNPV---------------------------NSTVPIAAEIFKKAGMYDEKKLFGVTTLDVVRARTFYAGKANVPVAEVNVPVIGGHAGVTILP-LFSQVSSHFLSTQTVATPQANLSSDILTALTKRTQDGGTEVVEAKAGKGSATL------------------------------------SMAYAGALFADACLKGLNGVPDVIECSYVQSTITFFASKVRLGKNGVEEVLDLGPLSDFEEGLEALKPELKSSIEKGVKFANQ.... 352
46 -9.390[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  10  1MK----KNVLIIGA-GGVAQVVAHKCAQNSDDIHIASRTVDKCRKIVESVREKKSEVKLEAHALDALDVEATKALIVGSQIVINVGSAF------------------NMSVLRACMDTGVAYMDTAIHEEPNKICETPPWYGNYEWKRAAEC...................................................................................................................................................................................................................................................... 138
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.