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Query: [GMO] KOG1460 GDP-mannose pyrophosphorylase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGSSMEEKVVAVIMVGGPTKGTRFRPLSLNIPKPLFPIAGQPMVHHPISACKRIPNLAQIYLVGFYEEREFALYVSAISNELKVPVRYLREDKPHGSAGGLYHFRNLIMEDSPSHIFLLNCDVCCSFPLPKMLEAHRGYGGIGTLLVIKVSPESASQFGELVADPVTNELLHYTEKPETFVSDRINCGVYVFTPEIFNAIGDVSTQRKDRATLKRVSSFEALQPATRIPTDFVRLDQDILSPLAGKKRLYTYETMDFWEQIKSPGMSLRCSGLYLSQFRLTSPQLLASGDGTRSAIVIGDVYIHPSAKVHPTAKIGPNVSISANARVGPGVRLMSCIILDDVEIMENAVVTNAIVGWKSSIGRWSRVQAEGVYNSKLGVTILGDSVAVEDEVVVTSSIVLPNKTLNVSVQDEIILLast
1 -124.000[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali  100  1MGSSMEEKVVAVIMVGGPTKGTRFRPLSLNIPKPLFPIAGQPMVHHPISACKRIPNLAQIYLVGFYEEREFALYVSAISNELKVPVRYLREDKPHGSAGGLYHFRNLIMEDSPSHIFLLNCDVCCSFPLPKMLEAHRGYGGIGTLLVIKVSPESASQFGELVADPVTNELLHYTEKPETFVSDRINCGVYVFTPEIFNAIGDVSTQRKDRATLKRVSSFEALQPATRIPTDFVRLDQDILSPLAGKKRLYTYETMDFWEQIKSPGMSLRCSGLYLSQFRLTSPQLLASGDGTRSAIVIGDVYIHPSAKVHPTAKIGPNVSISANARVGPGVRLMSCIILDDVEIMENAVVTNAIVGWKSSIGRWSRVQAEGVYNSKLGVTILGDSVAVEDEVVVTSSIVLPNKTLNVSVQDEIIL 415
2 -79.200[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  21  1........MRAVLMAGG--SGTRLRPLTCDLPKPMVPILNRPIAEHIINLLKRHH-ITEVIATLHYLPDVLRDYFQD-GGDFGVQMTYVEEDQPLGTAGCVKNIAELL----DETFLVISGDSITDFDLGEAIAFHKQKQSKATLILTRV--PNPIEFGVVITD-EAGKIKRFLEKPSEIFSDTVNTGTYILEPEVLEYLPSNTECDFSKDLFPL--------------------------LLAKDEPMYGYVAEGYWCDVGHLDAYREAQYDGLDRKVSPGLWIGQNTYIDPSAHIEAPAVIGNNCRIGARVQIEAGTVIGDNVTIGADANLKRPIVWNGAIIGEEAQLSACVISRGTRVDRRAHVLE---------ASVVGSLSTVGEEAQISPGVVWPSKKIESGLNINLI. 375
3 -74.600[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  15  15.KYELVKDTLVLILAGG--RGSRLYELTDKRAKPALYFGGNRIIDFALSNCLNSG-LNRIGVVTQYAAHSLLRHLQNGWS-LPARQQIDDSTWYRGTADAVYQNMAIIRDHCPKYILILAGDHIYKQDYSQMLLDHIHSGAKCTVGCIEVEREKATEFGVMAVN-ENLKVKSFVEKPKKPNTSLASMGIYVFDADYLYDV---------------------LEREVSSPYTSHDFGKDILPKALEEGVLYAHPFEIYWRDVGTLDSFWQSNIDLVCENPQVQTYPSKFFYKKENARPVDNSLISGGCVITDASI--SYSVLFDRIKINEGSQIDHCVVLPQVTIGKNCKLKRCIIDRHSVIPDGMEIGVDLELDRQ-RFRVSSGGVVLVTPSMLK---KLNGEEVASEA...... 436
4 -67.800[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  16  79..NADPKNVASIILGGG--AGTRLFPLTSKRAKPAVPIGGCRLIDIPMSNCINSG-IRKIFILTQFNSFSLNRHLSRTYN--DGFVEVLAATQTSGTADAVRQFIWVFKTKNVEHVLILSGDHLYRMDYMNFVQKHIESNADITVSCLPMDESRASDFGLLKID-QSGKIIQFSEKPKAESPYIASMGVYVFRKEVLLKLLRSSY------------------------PTSNDFGSEIIPLAVGEHNVQAFLFNDYWEDIGTIGSFFDANLALTEQPPKFQFY--QKTPFFTSPRFLPPTKVDKCRILDSIVSHGCHSIVGIRSRLESGVELQDTMMMGADFYQTEAEIASLLAEGKVPVGVGQNTKIKN--------CIIDKNAKIGKNVVIANADVEEGDRPEEGIRSGITV 505
5 -65.600[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  13  19..QSRRQRLQAILLADS--FATKLLPLTLERPNVLLPLVNIPMIDYTLAWLESAG-IEEVFVFCSMQVIDYLNNSDW-YSHKDFTVKTIESPQNSTSAGDALREQQIETSQIQGDFVLVNGCIVSNMPLTQLIQEHRDRKKKDEKAIMTMVIRNPLTKQLLYYDEDNICFKSLLDRNPLLCSDMQDCYIDICSLEVLSLFVDNFDYQHMRCDFVEGV---------------------LADDIIGYKIFTHEISSCYASRIENFRSYDMVSKDIIQRLERQGIYKASDATQLPSAHVGASYVIGHATNIGSGTKI-LNSVIGNGCSIGSNVVIQGSYIWNNVTVEDGCEIRNAIVCDEVKVCAGAIVKP---------GVVLSFKVVVGRDFVVPAYSQV............... 418
6 -65.100[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  16  33..QSIPIEFQAVVFAGF---GNSLYPLTGSLPKALLPIGNKPMLHYPLYWLEAAG-FTSAILICMEEAEAHINAWLRSGYEGHMRIHVEALDDSKSSADALRAVSHLIKSQKQNDFVCLSCDSIVGLPPIYGLDKFRLDNPSALAVYSPVLKYEIDAKQLIGIEEKTSRLLYAKSSADTLNTNLSDAHIFVFKHWVIDLIRE--------------------------KESISSIRGDLIPLVKCQYQKSFTVRENIQRFLSSPNNIDNYDGGLSSQAKLTPEQRLVDVTVSERALVGADCMVNEGTTIKDNSNIK-KSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLESCIVASGAQIGAKSKLRE----------CEIGVDHRVEAGRIARGERLVDMEKIETDMD..... 468
7 -64.600[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  15  2......KMRKGIILAGG--SGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFQQLLGD-GSQWGLNLQYKVQPSPDGLAQAFIIGEEFI--GGDDCALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHV--NDPERYGVVEFD-KNGTAISLEEKPLEPKSNYAVTGLYFYDNDVVQMAKNLKPSARGELEITDINRI----------------------YLEQGRLSVAMMGRGYWLDTGTHQSLIEASNFIATIEERQG---LKVSCPEEIAFRKGFIDVEQVRKLAVPLIKNNYGQYLYKMTKDSN..................................................................................... 293
8 -48.600[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  16  2....RKKVRKAVIPAAG--LGTRFLPATKAQPKEMLPIVDKPAIQYIVEEAAESG-IEDILIITGRNKRSIEDHFDRSAE--LANIHYIRQKEPLGLGHAVLCAEHFI---GDEPFAVLLGDDIMVSETPALRQLMDDVYGTEVVGVQSVLPEDVSKYGIINTSGSQGEVNDLVEKPEEAPSEIAVMGRYVLNSSIFSVLKTIGRGAGNEIQLT-----------------------DALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEMRSQL--LAYLEDVIKRETKEML................................................................................................................ 296
9 -42.300[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  15  1........MKAIILAAG--LGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEKG-INDIIIIVGYLKEQFDYL----KEKYGVRLVFNDKYADYNNFYSLYLVKEEL----ANSYVIDADNYLFKNMFRNDLTRST---------YFSVYREDCTNEWFLVYG-DDYKVQDIIVDSK---AGRILSGVSFWDAPTAEKIVSFIDKAYVS------------------GEFVDLYWDNMVKDNIKELDVYVEELEGSIYEIDSVQDYRKLEEILKNE.......................................................................................................................................... 228
10 -40.500[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  15  1........MEAVILAAG--FGSRLGHHTREIPKALLKIGKRPLIYYTVQTLMENG-IRDVVVVTGHKGYVLREYLSQ--FDLNFKFVHNSLYKKTNNIYSLYLAMDHV----SKGFYILNSDVLFHPGI--FRELHSSTKENLILSVDTFKELGEEE---MKVKIEDGVVKRISKQLNPSEADGEYIGIARVEENIIDDLYN------------------HVSRVMERKGRRVFYEEAFQSMMDDGIAVYYETTKGLWIEIDTPADLMKARYEIYPKIQ........................................................................................................................................ 240
11 -37.800[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  15  3.....QNTLNIVILAAG--KGTRMYS---KMPKVLHEIGGETMLGRVIDTAAALN-PQNICVVVGHGKEQVLDTVKR-------DVVWVEQTEQLGTGHAVKTALPHLAA--EGRTLVLYGDVIDVETLETLLEAAGN-----EVGLLTDVPADPSGLGRIIRD-SSGSVTAIVEEAAQKAVKEINTGILVLPNAKLEAWLNSLSSNNAQGEY---------------------LTDLIAKAVADGIKIHPVQVRSS-AGVNNKLQLAELERIFQTEQAQELLKAGVTLRDPARFDLRGRLKHGQDVVIDVNCIFEGKIELGDNVEIGANCVIKNAKIGANSKIAPFSHLEGCEVGENNQIGPYARLRP---------QAKLADDVHVGNFVEIKNAAIGKGTKANH........ 362
12 -19.800[M] COG0836 Mannose-1-phosphate guanylyltransferase  ali follow..  13  2..NEQSRKITPVLLAGG--AGSRLWPVSRDLPKQFQPLVGLSTYQQTLKRVGDKSLYSEPLVITN---EDFRFFARRQAEEIDLPATVVLEPARRDSAAAMAAAAVLAERREPGCVLALAADHVVL-KFSEAVKLGAKAADQGNIVVFGLVPTEPTSYGYIKPGDAIDTVDAFVEKPDVTTAISYNSGNFLFRSDVM-------IAELKAFAPEILAAVTQAVEQYESDLGFVRLHQASFEVIEKTKRMAVVHGHFRWSDIGSWDAIWEIA-----------------DKHDNDNALEGDGVFSEGCLIHSTQLLTTVVGAKDLVVVATKDAV---LVVPKNRVQDVKGLVDTL............................................................. 352
13 -16.600[G] KOG2638 UDP-glucose pyrophosphorylase  ali follow..  13  100NISSVLNKLVVVKLNGGL--GTS---MGCKGPKSLIGVNENTFLDLTVQQIKTYNTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRPPGHGDIYASFYDTFIGEGKEYIFVSNIDNLGAT-LNHLINPPNGKRCEFVMEVTNKTRAD-VKGGTLTQYEGKLRLVEIAQVPKAHVDEIFNTNNLWISLAAVKRLQEQNAIDMEIIVNAKTLD---------GGLNVIQLETAVGAAIKSFENSLGINVRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSLTVSGDVTFGKNVSLKGTVIIGDRIDIPPGAVLENKIVSGNLRILDH.................................................................... 508
14 -15.200[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  11  1........MLTLLMCGG--KGTRLG----RGEKPLFEVCGMKLIDHSLLQYKDF----DVIAITSPHTPATESYLAEKGVE-------VYRAAGKGYIEDYSEACREL--AINEPVIVASADIIRDIAFDIVDAYMKTIKPALTVVMEEIYSIEKDSVVNVNTVADVERAERLWTTMRK............................................................................................................................................................................................................................................ 174
15 -14.600[R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily  ali follow..  17  3..................................................................................................................................................................................................................................................................................YYAFEGLIPVVHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDLILEAGSNLQDGCIMHDTIVHENGHIGHGAILHGCVVGRDALVGMNSVI---------MDGAVIGEESIVAAMSFVKAGFQGEARQLLVGSPARVL. 141
16 -14.500[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  11  3.........NFTVIIPARYASTRL--------KPLAEIAGKPMIAHVFEKAMQSG-AKRVIVATD------HEQVATVARGFGAEVCMTSETHQSGT-ERLAEVVEKLGIAEDEIIVNIQGDLIPPAIVRQVAENLAKYQVKMASLAVNITDPEELF--VKVLTDHAGYVLYFSRAPIPWHRDLRHIGIYAYRAGFIKQYIQWQPSVLEQIE-----------------------SLEQLRVLWYGEKIHVELAREV-VGVDTAEDLEKVRSIL............................................................................................................................................. 256
17 -14.200[Z] KOG3121 Dynactin, subunit p25  ali follow..  15  6..................................................................................................................................................................................................................................................................................TYYSKDEYVETASGNKVSRHTVLCGNIILNGKVIVQSGAIIRGDVRTGRYCVIGKNSVIRPPHVGEHVFVGEGAVVSAATIGSYVYIGKNAIIGR---------RCVLKDCCVIEDGAVLPPETTVSSYMRYTARGTIEG. 154
18 -13.300[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  13  6..AKSTRRIVAVVPAAG--IGSRMQ---MDKPKQYLHIHGKTILEHTLSVLLGYPLIEKIILAVAANDPYISTCPLLTHPK--IQLVEGGSSRADSVLNGLNAVKSAVQNSEDFWVMVHDAPCLTHQDLDKLVQVEDQNGAILAIPATD-TIKRALHNQQIHYTEDRSQLWL-AQTPQFFPIATLAQALEQALAQGLQVTDEASAME................................................................................................................................................................................................................ 203
19 -12.300[E] COG2171 Tetrahydrodipicolinate N-succinyltransferase  ali follow..  14  99..............................................................................................................................................................................................................................................................................................................QKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVSCAQIGKNVHLSGGVGIGGV-LEPLQANPTIIEDNCFIGARSEVEGSVISMGVYIGQSTRIYDRE 218
20 -12.100[M] KOG2388 UDP-N-acetylglucosamine pyrophosphorylase  ali follow..  13  121RGVVEARNAAFVLVAGGL--GER---LGYNGIKVALPRTGTCFLQHYIESILALQEIPFIIMTSDDTHSRTLDLLEL-NSYFGMQVHLLKQEQIQMDFSSMLVAATQLLCLKVFIQFLMEIHNSLMTSLVASLGVSATKQYHVNSLAVPRKAKE-AIGGISKLTHVDGRNVEYNQLDPLLRASGFNINQLILELGPYKDE-----LQKTGGAIKEFVNPKYKDSTKTAFKSSTRLEQDYPKTLPPTARVGFTVMDIWYAPVKNNPEDAAKVPKGNPYHSATSGEMAIYRANSLILQKAGVKVEEPVKQVLNGQEVEVWSRITWKPKWGMIFSDIKKKVSGNCEVSQRSTMARNVFIKDLSLDGALIVDSIDDAEVKLGGLIKNNGWTMESDTSVPEEIRIRGFRFNKVEQLEKKL 600
21 -12.000[M] COG1083 CMP-N-acetylneuraminic acid synthetase  ali follow..  11  3....IIMTRIAIIPARAGSKGIK---------KNLQLVGGVSLVGRAILAAQESGMFDQIVVTSD------GENILKEATKYGAKPVARPESLAQSDTRTIDAILHCLENISQGTAALLTSPLRNALDIRNAMEIFLGGKYKSVVSACEC---EHHPYKSFTLEGTEVQPIHELTDFESPRQKLANGAIYINDIQSL.......................................................................................................................................................................................................................... 187
22 -10.600[R] COG2068 Uncharacterized MobA-related protein  ali follow..  15  3LPAKSRLKVGIVLLAAG--RSSRMG----GPNKLLALFDGKPLVRRTAERALGSK-ASGTIVVTGHQRERVRAALSGLDVTFADNPDFAN-----GLSTSLKAGIAYLPEDTAGAMIVL-GDMVVSGDLDRLIDAFRKAGGNSVVRASQGKRGNPVLLPIAHLEGDTGARHLVEAEGLDVVDVEIGEGASV................................................................................................................................................................................................................................ 189
23 -10.500[M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog  ali follow..  15  3.........DILFIIQARMGSTRL--------KVLRPLGSNRLLDILVHRVRQSAFRDNLVIATSDKET--DDILEAHCIKQGFRVFRGSEE------RVLDRFVKVIEAVKPSVIIRLTGDFVDPELLDVMIQAHFDQGSDYT-------YILNAPLGICGEVVNANLLIDISRIQALEDQYQEHVTLYIRNH-------------------PALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDVSASELITLLNRNPDAAT........................................................................................................................................... 235
24 -10.300[M] COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase  ali follow..  16  2..................................................................................................................................................................................................................................................................................................IDKSAFIHPTAIVEDGAVIGANAHIGPFCIVGPQVEIGEGTVLSHVVVNGQTKIGRDNEITRVEIGDRNRIRESVTIHRGTVQGGGL--TKVGSDNLLMINAHVAHDCTVGNRCILAN....... 137
25 -9.580[M] COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase  ali follow..  17  76....................................................................................................................................................................................................................................................................VADPYVAFAKVAQALDSTPSPAHGIAPSAVIAEDAKLGHNVSIGANAVIESGVQLGDNVVIGAGCFIGKQARLDNTKLWANVTIYHKVEISDCLIQSGTVIGADANERGEWIKIPQLGSVRIGDRVEIGACTTIDRGAL-DDTVIEDNVIIDNQL 235
26 -9.360[H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A  ali follow..  13  1......MKHVNVLLAGG--ASRRF-----GEPKAFVKWKGRMLYECAKEALGE----QTVIISRPEFIDRFQEN----------ENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTLIQRRTMLELKRLMIAGADAVVPLIAIYHKRIMPVLYDQLSEKRLRISDLLGR............................................................................................................................................................................................................................................... 159
27 -9.190[G] COG4284 UDP-glucose pyrophosphorylase  ali follow..  13  96LEAIGKGEVAVILMAGG--QGTR---LGSSQPKGCYDISKKSLFQIQAEKLIRLQDMVKWYIMTSGPTRAATEAYFQEHNYFGLQITFFNQGTPDGNGGLYRAIKEDFDRRGIKHVYMYCVDVLSKIADPVFIGFAIKHGFELATKAVRKRDAH-ESVGLIATKNEKPCVIEYSEISNELAEAAGNIVNHYYLVDLLKRDLDQWCENMPYHIAKKKIPAYDSVTGKYTKPTEIKLEQFIFDVFLNKFGCLEVDRCKEFSPLKNGPGS.................................................................................................................................................... 414
28 -9.150[R] COG4801 Predicted acyltransferase  ali follow..  16  1..............................................................................................................................................................................................................................................................................................................MLKHLLVPDNTRIDSRIVVEGDVIVGNHSSIQYSISGDMVIMGEGVAVSGDVACSDTRIDMWSKMGSNVEVGKN---AYLGEFVSIEGKLTVEGDLVGKEVKIKGGF...... 107
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.