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Query: [J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASRKKRAAKISEDSEEEQSRRQRLQAILLADSFATKLLPLTLERPNVLLPLVNIPMIDYTLAWLESAGIEEVFVFCSMQVIDYLNNSDWYSHKDFTVKTIESPQNSTSAGDALRYIYEQQIETSQIQGDFVLVNGCIVSNMPLTQLIQEHRDRKKKDEKAIMTMVIRQSLITDHQLFIAVNPLTKQLLYYDEDNICFDKSLLDRNPSVLLCSDMQDCYIDICSLEVLSLFVDNFDYQHMRCDFVEGVLADDIIGYKIFTHEISSCYASRIENFRSYDMVSKDIIQRRTFPYVPDMKFSGNRTLKLERQGIYKASDATQLPSAHVGASYVIGHATNIGSGTKILNSVIGNGCSIGSNVVIQGSYIWNNVTVEDGCEIRNAIVCDEVKVCAGAIVKPGVVLSFKVVVGRDFVVPAYSQVSLLRQPMEEDSDEENLLSGVDLQMESKLGLDGAGYIWRQACEDEWKHSVPPIPKDKLAEIIKAIDDDDTDDESVVTTSGDANTSINNDLFDFEREVDGTFLRAVEENIVADLAVLEINSLRLSYNMESAHCAGAIFYSMMKLAVSTPHSSINDLYRNASSIITRWKGLLGFYVKKSDEQIEVISRLEEMCEESAHELGTLFAHILRYMYEEENDLLQEVAILRWSDEKAGADESDKVYLKQCEPFITWLKETSDDEDGLast
1 -191.000[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali  100  1MASRKKRAAKISEDSEEEQSRRQRLQAILLADSFATKLLPLTLERPNVLLPLVNIPMIDYTLAWLESAGIEEVFVFCSMQVIDYLNNSDWYSHKDFTVKTIESPQNSTSAGDALRYIYEQQIETSQIQGDFVLVNGCIVSNMPLTQLIQEHRDRKKKDEKAIMTMVIRQSLITDHQLFIAVNPLTKQLLYYDEDNICFDKSLLDRNPSVLLCSDMQDCYIDICSLEVLSLFVDNFDYQHMRCDFVEGVLADDIIGYKIFTHEISSCYASRIENFRSYDMVSKDIIQRRTFPYVPDMKFSGNRTLKLERQGIYKASDATQLPSAHVGASYVIGHATNIGSGTKILNSVIGNGCSIGSNVVIQGSYIWNNVTVEDGCEIRNAIVCDEVKVCAGAIVKPGVVLSFKVVVGRDFVVPAYSQVSLLRQPMEEDSDEENLLSGVDLQMESKLGLDGAGYIWRQACEDEWKHSVPPIPKDKLAEIIKAIDDDDTDDESVVTTSGDANTSINNDLFDFEREVDGTFLRAVEENIVADLAVLEINSLRLSYNMESAHCAGAIFYSMMKLAVSTPHSSINDLYRNASSIITRWKGLLGFYVKKSDEQIEVISRLEEMCEESAHELGTLFAHILRYMYEEENDLLQEVAILRWSDEKAGADESDKVYLKQCEPFITWLKETSDDEDG 676
2 -86.400[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  22  18LGPISGGRNR---GNIQLQSIPIEFQAVVFAGF-GNSLYPLTGSDPKALLPIGNKPMLHYPLYWLEAAGFTSAILICMEEAEAHINAWLRSGYERIHVEAPTILDDSKSSADALRAVSHLKMLTDTHQNDFVCLSCDSIVGLPPIYGLDKFRLDNPSALAVYSPVL-SQSKEIDAKQLIGIEEKTSRLLYAKGSDFTFRMSLLWKHPRVTLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYLVKCQYQKSFTVRENIQR-FLSSPNNIDNYDGGLSSQEIKINALIAKDGIICSRNKCIAKLTPEQRLVDVTVSERALVGADCMVNEGTTIKDNSNIKKSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLESCIVASGAQIGAKSKL-RECEIGVDHRVEAGRIARGERLVDMEKIETDMD........................................................................................................................................................................................................................................................ 468
3 -70.600[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  18  1........................MRAVLMAGGSGTRLRPLTCDLPKPMVPILNRPIAEHIINLLKRHHITEVIATLHYLPDVLRDYFQDGGDFGVQMTYAVEEDQPLGTAGCVKNIAE------LLDETFLVISGDSITDFDLGEAIAFHKQKQSKATLILTR---------------VPNPIEFGVVITDEAGKI--KRFLEKPSTSEIFSDTVNTGTYILEPEVLEYLPSNTEC-----DFSKDLFPLLLAKDEPMYGYVAEGYWCDVGHLDAYREAQYDGLDRKVKLDFAYREN---------SPGLWIGQNTYIDPSAHIEAPAVIGNNCRIGARVQIAGTVIGDNVTIGADANLKRPIVWNGAIIGEEAQLSACVISRGTRVDRRAHVLEASVVGSLSTVGEEAQISPGVRVWPSKKIESGAILNINLI................................................................................................................................................................................................................................................. 375
4 -65.600[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  13  3..................SSMEEKVVAVIMVGGKGTRFRPLSLNIPKPLFPIAGQPMVHHPISACKRIPLAQIYLVGFYEEREFALYVSASNELKVPVRYLREDKPHGSAGGLYH---FRNLIMEDSPSHIFLLNCDVCCSFPLPKMLEAHRGYGGIGTLLVIKVSPE-------------SASQFGELVADPVTNEL-LHYTEKPE--TFVSDRINCGVYVFTPEIFNAIGDVSTQRKDRATLKRVSILSPLAGKKRLYTYETMDFWEQIKSPGMSLRCSGLYLSQ------------------FRLTSPQLLASGDGTRSAIVIGDVYIHPSAKVHPTAKIPNVSISANARVGPGVRLMSCIILDDVEIMENAVVTNAIVGWKSSIGRWSRVQAVTILGDSVAVEDEVVVTSSIVL.................................................................................................................................................................................................................................................................. 400
5 -60.200[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  12  6........NSSIVKLPNKYELVKDTLVLILAGGRGSRLYELTDKRAKPALYFGGNRIIDFALSNCLNSGLNRIGVVTQYAAHSLLRHLQNGWSFLPAQQIDDSTWYRGTADAVYQNMA---IRDHYCPKYILILAGDHIYKQDYSQMLLDHIHSGAKCTVGCIEVERE-------------KATEFGVMAVNENLKVK--SFVEKPKD-KPNTSLASMGIYVFDADYLDVLEREVSSPYTSHDFGKDILPKALEEGVLYAHTEGEIYWRDVGTLDSFWQSNIDLVCENPQLDIYD----QSWPIRGNPVQTYPSKFFYKKENARPVDNSLISGGCVITDAS-ISYSVLFDRIKINEGSQIDHCVVLPQVTIGKNCKLKRCIIDRHSVIPDGMEIGVDLELDRQFRVSSGGVVPSMLKKLNGEEVASEAHLD..................................................................................................................................................................................................................................................... 439
6 -54.500[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  12  61VLTPFVDQESHEPLLRTQNADPKNVASIILGGGAGTRLFPLTSKRAKPAVPIGGCRLIDIPMSNCINSGIRKIFILTQFNSFSLNRHLSRTYNFGNGVEVLAATQTSGTADAVRQFIWVFEDAKTKNVEHVLILSGDHLYRMDYMNFVQKHIESNADITVSCLPMDES-------------RASDFGLLKIDQSGKII--QFSEKPKGDDLKAMIASMGVYVFRKEVLLKLLRS---YPTSNDFGSEIIPLAVGEHNVQ-AFLFNDYWEDIGTIGSFFDANLALTEQPPKFQFYDQKTP-------FFTSPRFLPPTKVDKCRILDSIVSHGCFLREC---SVQHSIVGIRSRLESGVELQDTMMMGADFYQTEAEIASLLAEGKVPVGVGQNTKKNCIIDKNAKIGKNVVIANADGVEEGDRPEEGFHIRSGIT................................................................................................................................................................................................................................................. 504
7 -44.300[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  14  2......................KMRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQTPRFQQLLGDGSQWGLNLQYKVQPSPDGLAQAF-------IIGEEFIGGDALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYH---------------VNDPERYGVVEFDKNGTAI--SLEEKPL--EPKSNYAVTGLYFYDNDVVQMA-KNLKPSARGELEITDINRIYLEQGRLSVAMMGRGYWLDTGTHQSLIEASNFIATIEERQGL---------------------KVSCPEEIAFRKGFIDVEQVRKLAVPLIKNNYGQYLYKMTKDSN.............................................................................................................................................................................................................................................................................................................................. 293
8 -37.000[J] KOG2297 Predicted translation factor, contains W2 domain  ali follow..  17  235.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PTKRTTESFAEHFTKAGLTALVEYNERKIFEVKLKEIKAVLTSQVTEEINVDEVTEMVKQQVKDAKLPETEVVHVIWDGIMNAVQ-WSGKNQQQNSNAVLRQVKTWAPLLNTLCSTGNMEMELMYKVQMQCYEDAK-LMKVFPEVVRSLYEL--DVLAEDTILHWYRK-GTNPKGRQTFVKGLEPFVNWLEEAEEEE.. 426
9 -35.100[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  12  1........................MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEKGINDIIIIVGYLKEQFDYL---KEKYGVRLVFNDKYADYNNFYSLY-------LVKEELANSYVIDADNYLFKNMFRNDLTRS----------------------TYFSVYREDCTNEWFLVYGDDYKVQDII-------VDSKAGRILSGVSFWDAPTAEKIVSFIDKAYVSGEYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDYRKLEEILKNE..................................................................................................................................................................................................................................................................................................................................................................................................... 228
10 -34.200[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  12  2....................PQNTLNIVILAAGKGTRMY---SKMPKVLHEIGGETMLGRVIDTAAALNPQNICVVVGHGKEQVLDTVKR------DVVWVEQTEQLGTGHAVKTALPHLA------EGRTLVLYGDLIDVETLETLLEAAGN-----EVGLLTDVPA-------------DPSGLGRIIRDSSGSVTAIVEEKDADAAQKAVKEINTGILVLPNAKLEAWLNSLSSNNAQGEYLTDLIAKAVADGIKIHPVQVRSSAAGVNNKLQLAELERIFQTEQAQELLKAGVTLRDPARFDLRGRLKHGQDVVIDVNCIFEGKIELGDNVEIGANCVIKNAKIGANSKIAPFSHLEGCEV-DDVHVGNFVEIKNAAIGKGTKVGSKTNFGAGTIIGDEVRIGSNCVLVSPVKIGNKVTTGAGSTITRNVEDGK.............................................................................................................................................................................................................................................. 434
11 -33.700[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  11  2....................RKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVEEAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLRHYIRQKEPLGLGHAVLCAEH--------DEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGVQSVL-----------PEDVSKYGIINTSGSQGHV-NDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVLKTIGRGAGNEIQLTDAL--REVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLM..................................................................................................................................................................................................................................................................................................................................................................................................... 272
12 -32.400[J] KOG2767 Translation initiation factor 5 (eIF-5)  ali follow..  12  31...........................................................................................................................................................................................................................................................................................................................................GIKTAVLNVADISHALLGAQTSISVD---KDRYLVNGVHEPAKLQINKFVLCGSCK-KDNDLVRDCKACGKRTPMDLRHKLSSFILKNPPDSVSGSKKKKKAATASANVRGGGLSISDIAQGKSQNAPSDGTGSSTPQHHDEDEDELSRQIKAAASTLEDIEVKDDEWAVDMSEEAIRARAKELEVNSELTQLDEYGEWILEQAGEDKENLPSDVELYKKAAELDVLNDPKIGCVLAQCLFDEDIVNEIAEHNAFFTKILVTPEYEKNFMGGIERFLGLEHKDLIPLLPKILVQLYNN--DIISEEEIMRFGTKSSKPKEVSKKVRRAAKPFITWLETAESDDDE 401
13 -32.400[J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain  ali follow..  12  31...........................................................................................................................................................................................................................................................................................................................................GIKTAVLNVADISHALLGAQTSISVD---KDRYLVNGVHEPAKLQINKFVLCGSCK-KDNDLVRDCKACGKRTPMDLRHKLSSFILKNPPDSVSGSKKKKKAATASANVRGGGLSISDIAQGKSQNAPSDGTGSSTPQHHDEDEDELSRQIKAAASTLEDIEVKDDEWAVDMSEEAIRARAKELEVNSELTQLDEYGEWILEQAGEDKENLPSDVELYKKAAELDVLNDPKIGCVLAQCLFDEDIVNEIAEHNAFFTKILVTPEYEKNFMGGIERFLGLEHKDLIPLLPKILVQLYNN--DIISEEEIMRFGTKSSKPKEVSKKVRRAAKPFITWLETAESDDDE 401
14 -29.900[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  14  1........................MEAVILAAGFGSRLGHHTREIPKALLKIGKRPLIYYTVQTLMENGIRDVVVVTGHKGYVLREYLSQFD-LNFKFVHNSLYKKTNNIYSLY-------LAMDHVSKGFYILNSDVLFHPGIFREL-----HSSTKENLILSVDTFKELGEEEMKVKIEDGVVKRISKQLNPS----------------EADGEYIGIARVEENIIDDLYNHVS-RKGRRVFYEEAFQSMMDDGIAVYYETTKGLWIEIDTPADLMKARYEIYPK..................................................................................................................................................................................................................................................................................................................................................................................................... 238
15 -20.500[Z] KOG3121 Dynactin, subunit p25  ali follow..  23  16........................................................................................................................................................................................................................................................................................................................TASGNKVSRHTVLSQNIILNGKVIVQSGAIIRGDLTGRYCVIGKNSVIRPMHVGEHVFVGEGAVVSAATIGSYVYIGKNAIIGRRCVLKDCCVIEDGAVLPPETTV.................................................................................................................................................................................................................................................................. 140
16 -18.500[R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily  ali follow..  17  13........................................................................................................................................................................................................................................................................................................................VHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYLEAGSNLQDGCIMHDTIVHENGHIGHGAILHGCVVGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFQG.................................................................................................................................................................................................................................................................. 127
17 -16.900[E] COG2171 Tetrahydrodipicolinate N-succinyltransferase  ali follow..  17  99........................................................................................................................................................................................................................................................................................................................QKEGFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVSCAQIGKNVHLSGGVGINPTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIGQST.................................................................................................................................................................................................................................................................... 212
18 -15.400[R] COG4801 Predicted acyltransferase  ali follow..  10  1........................................................................................................................................................................................................................................................................................................................MLKHLLVPDNTRIDSRIVVEGDVIVGNHSSIQYSISGDMVIMGEGVAVSGDVACSDTRIDMWSKMGSNVVGKNAYLGEFVSIEGKLTVEGDLDVGKEVKIKGGFVAK................................................................................................................................................................................................................................................................. 110
19 -15.100[G] KOG2638 UDP-glucose pyrophosphorylase  ali follow..  12  88....PYEKIKARGLPDNISSVLNKLVVVKLNGGLGTS---MGCKGPKSLIGVNENTFLDLTVQQIEHTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSR---GHGDIYASFYNSGLLDTFIGEGIFVSNIDNLGATVDLYILNHLINPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKSLAAVKRLQEQN-IIVNAKTLDGGLNVIQLETAVGAAIENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIIAN--GDRIDIPPGAVLENKIVSGNLRILDH.............................................................................................................................................................................................................................................................................................................. 508
20 -14.400[M] COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase  ali follow..  16  9.............................................................................................................................................................................................................................................................................................................HPTAIVEDGAVIGANAHIGPFCIVGPQVEIGEGTVLKSHVVVNGQTIGRDNEIYQFASITRVEIGDRNRIRESVTIHRTKVGSDNLLMINAHVAHDCTVGNRCILANNATLAGHVSV.................................................................................................................................................................................................................................................................. 147
21 -14.000[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  1........................MLTLLMCGGKGTRLG----RGEKPLFEVCGMKLIDHSLLQYKDF---DVIAITSPHTPATESYLAE------KGVEVYRAAGKGYIEDYSEACRELAI-----NEPVIVASADIIRDIAFDIVDAYMKTIKPALTVVVNIIDSLLINTWQEEEIYSIEKDSVVNVNTVADVERAERLWTTMRKERGWQRD.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 181
22 -13.000[M] COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase  ali follow..  19  101...................................................................................................................................................................................................................................................................................................................APSAVIAEDAKLGHNVSIGANAVIESGVQLGDNVVIAGCFIGKQARLGDNTKLANVTIYHKVEIGSDCLIQSGRIGDRVEIGACTTIDRGALIAHNVHIGYGSALAGGTVIAGSTRIGKY......................................................................................................................................................................................................................................................... 264
23 -12.800[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  12  2..............TTPIAKSTRRIVAVVPAAGIGSRMQ---MDKPKQYLHIHGKTILEHTLSVLLGYPIEKIILAVAANDPYISTCPLLTHP-----KIQLVEGGSSRADSVLNGLNAVKSAVQNSEDFWVMVHDAALTHQDLDKLVQV-----EDQNGAILAIPATDTIKRALHNQQIHYTEDRSQLWLAQTPQFFPIATLAQALEQALAQGLQEASAM--RPHLVAGRSDNIKVTRPEDALAEFYLSRT........................................................................................................................................................................................................................................................................................................................................................................................................................................ 237
24 -11.100[R] COG2068 Uncharacterized MobA-related protein  ali follow..  15  5..................AKSRLKVGIVLLAAGRSSRM-----GPNKLLALFDGKPLVRRTAERALGSKASGTIVVTGHQRERVRAALS-----GLDVTFADNPDFANGLSTSLKAGIAYLPEDT---AGAMIVLGDMVVSGDLDRLIDAFRKAGGN....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 133
25 -10.100[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  10  2......................TNFTVIIPARYASTRL--------KPLAEIAGKPMIAHVFEKAMQSGAKRVIVATDH--EQVATVAR-----GFGAEVCMTSETHQSGTE--RLAEVVEKLGIAEDEIIVNIQGDLIPPAIVRQVAENLAK-YQVKMASLAVNITDPEELFNPNAVKVLTDHAGYVLYFSRAPIPWHRDQFASLPKEKSTRGLRHIGIYAYRAGFIKQYIQWQPSVLEQIESLEQL-----YGEKIHVELAREVPPVGVDTAEDLEKVRSIL........................................................................................................................................................................................................................................................................................................................................................................................................ 256
26 -9.560[R] COG0110 Acetyltransferase (isoleucine patch superfamily)  ali follow..  16  68..................................................................................................................................................................................................................................................................................................................................CDYGYNIFLGNNFFANFDCVMLDVRIGDNCMLAPGVHIYTA----THPIDPVARNSGAELGKPVTIGNNVWIGGRAVINPGVTIGDNVVVASGAVVT................................................................................................................................................................................................................................................................. 163
27 -9.380[E] COG1045 Serine acetyltransferase  ali follow..  19  131.......................................................................................................................................................................................................................................................................................................................FLQNQVSVTFQVDIHPAAKIGRGIMLDHATGI---VVGETAVIENDVSILQSVTLGGTGKSGG---RHPKIREGVMIGAGAKILGNIEVGRGAKIGAGSVVLQPV.................................................................................................................................................................................................................................................................... 230

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.