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Query: [J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSLYEHAALPLASSPSILGPISGGRNRGNIQLQSIPIEFQAVVFAGFGNSLYPLTGSDALPKALLPIGNKPMLHYPLYWLEAAGFTSAILICMEEAEAHINAWLRSGYEGHMRIHVEAPTILDDSKSSADALRAVSHLIKSQKMLTDTHQNDFVCLSCDSIVGLPPIYGLDKFRLDNPSALAVYSPVLKYEHITSQSKEIDAKQLIGIEEKTSRLLYAKSSADVGSDFTFRMSLLWKHPRVTLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYLVKCQYQKSFTVRENIQRFLSSPNNIDNYDGGLSSQEIKINALIAKDGIICSRANNLPNYFELNKCIAKLTPEQRLVDVTVSERALVGADCMVNEGTTIKDNSNIKKSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLESCIVASGAQIGAKSKLRECEIGVDHRVEAGRIARGERLVDMEKIETDMDLast
1 -134.000[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali  100  1MSLYEHAALPLASSPSILGPISGGRNRGNIQLQSIPIEFQAVVFAGFGNSLYPLTGSDALPKALLPIGNKPMLHYPLYWLEAAGFTSAILICMEEAEAHINAWLRSGYEGHMRIHVEAPTILDDSKSSADALRAVSHLIKSQKMLTDTHQNDFVCLSCDSIVGLPPIYGLDKFRLDNPSALAVYSPVLKYEHITSQSKEIDAKQLIGIEEKTSRLLYAKSSADVGSDFTFRMSLLWKHPRVTLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYLVKCQYQKSFTVRENIQRFLSSPNNIDNYDGGLSSQEIKINALIAKDGIICSRANNLPNYFELNKCIAKLTPEQRLVDVTVSERALVGADCMVNEGTTIKDNSNIKKSIIGKNCVIGKGVVVSNSILMDNIVVEDGVRLESCIVASGAQIGAKSKLRECEIGVDHRVEAGRIARGERLVDMEKIETDMD 468
2 -86.400[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  22  1.................MASRKKRAAKDSEEEQSRRQRLQAILLADSATKLLPLTLER--PNVLLPLVNIPMIDYTLAWLESAGIEEVFVFCSMQVIDYLNNSDWYSHK---DFTVKTIESPQNSTSAGDALRYIYEQ----QIETSQIQGDFVLVNGCIVSNMPLTQLIQEHRDRKKKDEKAIMTMV------RQSLITDHQLFIAVNPLTKQLLYYD-----EDNICFDKSLLDRNPSVLLCSDMQDCYIDICSLEVLSLFVDNFDYQHMRCDFVEGVLADDIIGYKIFTHEISSYASRIENFRSYDMVSKDIIQRRTFPYVPDMKFSGN----------RTLKLERQGIYKASDATQLPSAHVGASYVIGHATNIGSGTKILNSVIGNGCSIGSNVVIQGSYIWNNVTVEDGCEIRNAIVCDEVKVCAGAIVPGVVLSFKVVVGRDFVVPAYSQVSLLRQPMEED 428
3 -65.100[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  16  3................................SSMEEKVVAVIMVGGGTRFRPLSLN--IPKPLFPIAGQPMVHHPISACKRIPLAQIYLVGFYEEREFALYVSAISNELKVPVRYLR---EDKPHGSAGGLYHFRNLIMEDS------PSHIFLLNCDVCCSFPLPKMLEAHRGYGGIGTLLVIKVSPE--------SASQFGELVADPVTNELLHYTEKPE------------------TFVSDRINCGVYVFTPEIFNAIGDPTDFVRLDQDILS-PLAGKKRLYTYETMDFWEQIKSPGMSLRCSGLYLSQ-------------------------------FRLTSPQLLASGDGTRSAIVIGDVYIHPSAKVHPTAKIGNVSISANARVGPGVRLMSCIILDDVEIMENAVVTNAIVGWKSSIGRWSRVQATILGDSVAVEDEVVVTSSIVLPNKTLNVSVQ 410
4 -60.600[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  13  1.................MEVIMNSSIVKLPNKYELVKDTLVLILAGGGSRLYELTDKR--AKPALYFGGNRIIDFALSNCLNSGLNRIGVVTQYAAHSLLRHLQNGWSFLPAERGRQQIDDSTWYRGTADAVYQNMAIIRD-----HYCPKYILILAGDHIYKQDYSQMLLDHIHSGAKCTVGCIEV--------EREKATEFGVMAVNENLKVKSFVEKPKDPPAMVG------------KPNTSLASMGIYVFDADYLYDVSSPYTSHDFGKDILPKALEESCMGRNTEGEIYWRDVGTLDSFWQSNIDLVCENPQLDIYDQSWPIRGNPVQTYPS-----------------KFFYKKENARPVDNSLISGGCVITDAS-ISYSVLFDRIKINEGSQIDHCVVLPQVTIGKNCKLKRCIIDRHSVIPDGMEIGVDLERQRFRVSSGGVVSMLKKLNGEEVASE.. 435
5 -60.400[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  15  1......................................MRAVLMAGGGTRLRPLTCD--LPKPMVPILNRPIAEHIINLLKRHHITEVIATLHYLPDV-LRDYFQDGGDFGVQMTYA--VEEDQPLGTAGCVKNIAELL----------DETFLVISGDSITDFDLGEAIAFHKQKQSKATLILTRVPNPI----------EFGVVITDEAGKIKRFLEKPSTSE-----------------IFSDTVNTGTYILEPEVLEYLPSNTEC-DFSKDLFPLLLAKDEPMYGYVAEGYWCDVGHLDAYREAQYDGLDRKVK----LDFAYRENSPGLWIGQNTYIDPSAHIEAPAVIGNNCRIGARVQIEAGTVIGDNVTIGADANLKRPIVWNGAIIGEEAQLSACVISRGTRVDRRAHVLESVVGSLSTVGEEAQISGVRVWPSKKIESGAILNINLI........... 375
6 -53.400[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  12  50...QKKIQTNLIRSVLTPFVDQESHEPLLRTQNADPKNVASIILGGGGTRLFPLTSKR--AKPAVPIGGCRLIDIPMSNCINSGIRKIFILTQFNSFSLNRHLSRTYNEVLAATQTSGDAGKKWFQGTADAVRQFIWVFED---AKTKNVEHVLILSGDHLYRMDYMNFVQKHIESNADITVSCLPM--------DESRASDFGLLKIDQSGKIIQFSEKPKGDDLKAMQVDTSILGLPPKAESPYIASMGVYVFRKEVLLKLLRSPTSNDFGSEIIPLAVGEH-NVQAFLFNDYWEDIGTIGSFFDANLALTEQPPKFQFYDQKTPFFT--------------------SPRFLPPTKVDKCRILDSIVSHGCFLREC---SVQHSIVGIRSRLESGVELQDTMMMGADFYQTEAEIASLLAEGKVPVGQNTKIKNCIIDKNAKIGKNVVINADGVEEGDRPEE... 495
7 -42.300[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  13  4......................................RKGIILAGGGTRLYPVTMA--VSKQLLPIYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFQQLLGDGSQWGLNLQYK---VQPSPDGLAQAFIIGEEFIGG--------DDCALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHVNDPE----------RYGVVEFDKNGTAISLEEKPLEP-------------------KSNYAVTGLYFYDNDVVQMAKNSARGELEITDINRIYLEQGRLSVAMMGRGYWLDTGTHQSLIEASNFIATIEERQGL----------------------------------KVSCPEEIAFRKGFIDVEQVRKLAVPLIKNNYGQYLYKMTKDSN..................................................................... 293
8 -32.500[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  13  2..................................PQNTLNIVILAGKGTRMY-----SKMPKVLHEIGGETMLGRVIDTAAALNPQNICVVVGHGKEQVLDTVKRD----------VVWVEQTEQLGTGHAVKTALPHLAA--------EGRTLVLYGDLIDVETLETLLEAAGNEVGLLTDVP-------------ADPSGLGRIIRDSSGSVTAIVEEKDADAAQKAVKE---------------INTGILVLPNAKLSLSSNNAQGEYYLTDLIAKAVADGIKIHPVQVRSSHLAAGVNNKLQLAELERIFQTEQAQELLKAGVTLRDPAR-----------FDLRGRLKHGQDVVIDVNCIFEGKIELGDNVEIGANCVIKNAKIGANSKIAPFSHLEGCEVGENNQIGPYARLRQAKLADDVHVGNFVEIKNAAIGKGTKANHLTYIGDAEVGSKTNF..... 377
9 -29.100[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  12  2..................................RKKVRKAVIPAGLGTRFLPAT--KAQPKEMLPIVDKPAIQYIVEEAAESGIEDILIITGRNKRSIEDHFTLKEMQQIADLANIHYIRQKEPLGLGHAVLCAEHFIG---------DEPFAVLLGDDIMVSELRQLMDVYDVYGTEVVGVQSV---------LPEDVSKYGIINTSGSQGHVYEVND-------------LVEKPSPEEAPSEIAVMGRYVLNSSIFSVLKTIGRGAGNETDALREVCRKE-PIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM..................................................................................................................................................... 276
10 -27.800[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  13  1......................................MKAIILAGLGTRLRPMTEN--TPKALVQVNQKPLIEYQIEFLKEKGINDIIIIVGYLKEQFDYLKEKYGVR-------LVFNDKYADYNNFYSLYLVKEEL----------ANSYVIDADNYLFKNMFRNDLTRS-----------------TYFSVYREDCTNEWFLVYGDDYKVQDIIVDSK----------------------AGRILSGVSFWDAPTAEKIVSGEFVDLYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDYRKLEEILKNEN........................................................................................................................................................ 229
11 -25.600[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  14  1......................................MEAVILAGFGSRLGHHT--REIPKALLKIGKRPLIYYTVQTLMENGIRDVVVVTGHKGYVLREYLSQFDLNFK-----FVHNSLYKKTNNIYSLYLAMDHV----------SKGFYILNSDVLFHPGIFRELHSSTKENLILSV------------DTFKELGEEEMKVKIEDGVVKRISKQLNPSE-------------------ADGEYIGIARVEENIIDDLYNRKGRRVFYEEAFQSMMDDGIAVYYETTKGLWIEIDTPADLMKARYEIYPKI........................................................................................................................................................ 239
12 -17.500[Z] KOG3121 Dynactin, subunit p25  ali follow..  20  16.................................................................................................................................................................................................................................................................................................................................................................TASGNKVSRHTVLSQNIILNGKVIVQSGAIIRGDLTGRYCVIGKNSVIRPMHVGEHVFVGEGAVVSAATIGSYVYIGKNAIIRRCVLKDCCVIEDGAVLPPETTVSSYMR..... 145
13 -15.900[R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily  ali follow..  19  13.................................................................................................................................................................................................................................................................................................................................................................VHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYLEAGSNLQDGCIMTDTIVHENGHIGHGAILHGCVVGRDALVGMNSVIDGAVIGEESIVAAMSFVKAGFQGEARQL..... 132
14 -15.400[E] COG2171 Tetrahydrodipicolinate N-succinyltransferase  ali follow..  15  102....................................................................................................................................................................................................................................................................................................................................................................GFRVVPPAAVRQGAFIARNTVLMPSYVNIGAYVDEGTMVDTWATVSCAQIGKNVHLSGGVGINPTIIEDNCFIGARSEVEGVIVEEGSVISMGVYIGQST............ 212
15 -15.100[R] COG4801 Predicted acyltransferase  ali follow..  18  1.................................................................................................................................................................................................................................................................................................................................................................MLKHLLVPDNTRIDTSRIVEGDVIVGNHSSIQYSISGDMVIMGEGVAVSGDVACSDTRIDMWSKMGSNVVGKNAYLGEFVSIEGLTVEGDLDVGKEVKIKGGFVAKGW....... 112
16 -13.700[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  11  1......................................MLTLLMCGGGTRL------GRGEKPLFEVCGMKLIDHSLLQYKDF---DVIAITSPHTPATESYLAEK----------GVEVYRAAGKGYIEDYSEACRELAI--------NEPVIVASADIIRDIAFDIVDAYMKTIKPALTVVMEGEPVGVNIIDSLLINTWQEEEIYSIEKDSVVNVNTVADVERAERL.............................................................................................................................................................................................................................................. 168
17 -12.500[G] KOG2638 UDP-glucose pyrophosphorylase  ali follow..  11  71.PSVDWGKIQRPPEDSIQPYEKIKARGLPDNISSVLNKLVVVKLNGGGTSM-------KGPKSLIGVNENTFLDLTVQQIEHLNKTPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPYPPGHGDIYASFYNS--LLDTFIGEGKEYIFVSNIDTVDLYILNHLINPPNGKRCEFVMVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNAKTLDGGLNVIQLETAVGAAIKSF---ENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFES--IPDMLELDHLTVSGDVTFGKNVSLKGTVIIIAN--GDRIDIPPGAVLENKIVSGNLRILDH..................................................... 508
18 -12.300[M] COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase  ali follow..  14  2...............................................................................................................................................................................................................................................................................................................................................IDKSAFIHPTAIVEDGAVIGANAHIGPFCIVGPQVEIGEGTVLKSHVVVNGQTIGRDNEIYQFASITRVEIGDRNRIRESVTIHRTKVGSDNLLMINAHVADCTVGNRCILANNATLAGHVSVDDFAI..... 152
19 -11.900[M] COG1664 Integral membrane protein CcmA involved in cell shape determination  ali follow..  9  1.....................................................................................................................................................................................................................................................................................................................................................................MDVVEKLVINGSGSSKGGTEINGSGTVAGDVECDTFSFNGNGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGTVKADGIDISGKAV 115
20 -11.900[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  10  2....................................TNFTVIIPARYASTRLP--------KPLAEIAGKPMIAHVFEKAMQSGAKRVIVATDHE-----------------QVATVARGFGAEVCMTSETHQSGTERLAEVVEKLGIAEDEIIVIQGDLIPPAIVRQVAENLAKYQVKMASLAVNITDPEELFNPNAVK-----VLTDHAGYVLYFSRAPWHRDQFASLPKEKSTRGQLVLSDHYLRHIGIYAYRAGFIKQYIQWQPSVLEQIESLEQL............................................................................................................................................................................................ 221
21 -11.300[M] COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase  ali follow..  17  103..............................................................................................................................................................................................................................................................................................................................................................SAVIAEDAKLGHNVSIGANAVIESGVQLGDNVVIAGCFIGKQARLGDNTKLANVTIYHKVEIGSDCLIQSVRIGDRVEIGACTTIDRGALD-DTVIEDNVIIDNQLQIAHN....... 240
22 -11.000[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  13  2............................TTPIAKSTRRIVAVVPAGIGSRM-----QMDKPKQYLHIHGKTILEHTLSVLLGYPIEKIILAVAANDPYISTCPLLTHPKIQL------------VEGGSSRADSVLNGLNAVKSAVQNSEDFWVMVH-DCLTHQDLDKLVQVEDQNGAILAI---------PATDTIKRALHNQQIHYTEDRSQLWLAQTPQFFPIATLAQALEQALAQGLQVTDEASAMEFAGFRPHLVAGRSDNIKVTRPEDALAEFYLSRT........................................................................................................................................................................................ 237
23 -10.700[M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog  ali follow..  6  2....................................NDILFIIQARMGSTRLP--------KVLRPLGSNRLLDILVHRVRQSARDNLVIATSDKETD-------------------ILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIILTGDFVDPELLDVMIQAHFDQGSDYTYLLIDISRIQALEDQYQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDVSASELITLLNRNPDAATETRG................................................................................................................................................................................................. 239
24 -10.000[R] COG2068 Uncharacterized MobA-related protein  ali follow..  14  5................................AKSRLKVGIVLLAGRSSRM------GGPNKLLALFDGKPLVRRTAERALGSKASGTIVVTGHQRERVRAAL--------SGLDVTFADNPDFANGLSTSLKAGIAYLPED-------TAGAMIVLGDGVVSGDLDRLIDAFRKAGGNSVVR............................................................................................................................................................................................................................................................................................. 137
25 -9.950[M] COG1083 CMP-N-acetylneuraminic acid synthetase  ali follow..  10  3..................................IIMTRIAIIPARAGSKGIK--------KNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDG-----ENILKEATKYGAKPVARPESLAQSDTRTIDAILHCLETLNI--------SQGTAALTSPLRNALDIRNAMEIFLGGKYKSVVSACECEHH...................................................................................................................................................................................................................................................................................... 141
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.