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Query: [V] KOG1515 Arylacetamide deacetylase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPSVGVKLYSVFFKFLLKHRLQNRIQSSGDESSSDPFGVTTRPEESVAAPNPLFTDGVATKDIHIDPLTSLSVRIFLPESALTPLEPSTSACVYSGKARTLNNIAGSDLLSRRNSLGSSNSLLSHKVESRRNSYGYTTGSSSPEAGSSDVYRGYAPSSSGGNSRKLPVMLQFHGGGWVSGSNDSVANDFFCRRMAKHCDIIVLAVGYRLAPENRYPAACEDGFKVLKWLGKQANLAECNKSMGNSRRPGGEVKKSEVNKHIVDAFGASLVEPWLANHADPSRCVLLGVSCGANIADYVARKAIEVGQNLDPVKVVAQVLMYPFFIGSVPTQSEIKQANSYFYDKPMCILAWKLFLPEEEFSLDHQAANPLVPGRSPPLKFMPPTLTIVAEHDWMRDRAIAYSEELRKVNVDAPVLEYKDAVHEFATLDMLLRTPQAQACAEDIAIWAKKYISLRGHEFSYLast
1 -135.000[V] KOG1515 Arylacetamide deacetylase  ali  100  1MPSVGVKLYSVFFKFLLKHRLQNRIQSSGDESSSDPFGVTTRPEESVAAPNPLFTDGVATKDIHIDPLTSLSVRIFLPESALTPLEPSTSACVYSGKARTLNNIAGSDLLSRRNSLGSSNSLLSHKVESRRNSYGYTTGSSSPEAGSSDVYRGYAPSSSGGNSRKLPVMLQFHGGGWVSGSNDSVANDFFCRRMAKHCDIIVLAVGYRLAPENRYPAACEDGFKVLKWLGKQANLAECNKSMGNSRRPGGEVKKSEVNKHIVDAFGASLVEPWLANHADPSRCVLLGVSCGANIADYVARKAIEVGQNLDPVKVVAQVLMYPFFIGSVPTQSEIKQANSYFYDKPMCILAWKLFLPEEEFSLDHQAANPLVPGRSPPLKFMPPTLTIVAEHDWMRDRAIAYSEELRKVNVDAPVLEYKDAVHEFATLDMLLRTPQAQACAEDIAIWAKKYISLRGHEFSY 460
2 -47.800[I] COG0657 Esterase/lipase  ali follow..  16  24.........................................................................................................RTSVSALRAGYDDFFYMPYVPNGVDVSCEVL----------ANIETDVLSPRFLMVGH----AVLYAHGGFFISGSPM--ASRALCASLADEVGAKFYIPAYQLAPEHPFPAALENMYDAYVALIDQKK-------------------------------------------FRPEDIIFSGDGAGAGLMLALTHYLKQKGLVCP----RALALISPWVDLTEDRFAGEGVKKELLLTRDMFRYCALQYTYADN-----FRNSLVSPLFG-NFGDFPPVFVQCGEQELFHTDACALAQILEGAGVQVTLDVWPGMWHLFQSMESVS--PCAHIAVARMGAWAHRMLESPAIAVQ. 307
3 -32.300[E] KOG4627 Kynurenine formamidase  ali follow..  13  58.............................................................................................................................................LRYGEGRQLVDVFYSEKTTNQA---PLFVFVHGGYWQEMDMSMSCS--IVGPLVRR-GYRVAVMDYNLCPQVTLEQLMTQFTHFLNWIFDYTEMTKVS------------------------------------------SLTFAGHSAGAHLLAQILMRPNVITA-QRSKMVWALIFLCGVYDLRELSNLESVNPKNIL-------------------GLNERNIESVSPMLWEYTDVTTKIYVVAAEHDSFIEQSRHYADVLRKKGYKASFTLFKGYDH-FDIIEETAI--DDSDVSRFLRNIEIE........... 300
4 -21.300[I] COG2272 Carboxylesterase type B  ali follow..  13  87....................................................................................................................................................LYLNVWAPAV---RHEPLPVMVWLHGGGYTIGAGSLPPYDG--QALAKR-GAIVVTVNYRLGH--AHPAALLDQIAALRWVQDNIAAFGGDTQNVTLFGESAGA--RSVLSLMASPLAKGLFHKAIIQSGYTLPDT-VALKKGVALAEHLGLAHATAEETFWPLDAPFKIAPTPISGDVVLPHPMLETFFAVMIGSNSDEASVLAVFGVDIAGQIQKMRRERRVGLGLIRLLYPGLGRQVCRDMVFTTLGYVVMQAQQRIGEPCWRYWFDGACHG-YVFDTLTRAEPTCHYVNENDLAFASQVAD....... 434
5 -19.900[T] KOG4389 Acetylcholinesterase/Butyrylcholinesterase  ali follow..  11  132....................................................................................................................................................LYINVWAPANPQNTTNGLPILIWIYGGGFMTGSATLDIYNA--DIMAAVGNVIVASFQYRVGAAEEAPGGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS--SSVNAQLMSPVTRGLVKRGMMQSGTMNDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWN-SFPSAPTIDGAFLPADPMTLMKT--LPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTGVLHGYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGN. 559
6 -18.800[R] KOG1516 Carboxylesterase and related proteins  ali follow..  51......................................................................................................PYAKPPVGDLRQPPEPWQGVLNCTTNRSKPMQRNMLLGIVEGSEDCLHLNVYVKA---KSEKPLPVIVWIYGGGFQKGEASRDIYSP---DYFMKKPVVFVAINYRLAADVPGNAGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGS--ASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFA-------FGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNS------FEGLFSYQLVDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTY 430
7 -18.100[I] KOG2112 Lysophospholipase  ali follow..  12  15...............................................................................................................................................................SPAGRHSASLIFLHGSG------SGQGLRMWIKQVLNQDLTF-IKIIYPTAPPR--SYTPMKGGISNVWF---------DRFKITNDCPEHLESIDVMCQVL-----TDLIDEEVKSGIKKNRILIGGFSMGGCMAMHLAYRNHQ--------DVAGVFAL-------------------------------SSFLNKASA---------VYQALQKSNGVLPELFQCHGTADEL-SWAEETNSMLKSLGVTTKFHSFPNVYHEL-----------SKTELDILKLWILTKLPGEMEKQK. 237
8 -17.400[R] COG2945 Predicted hydrolase of the alpha/beta superfamily  ali follow..  14  1........................................................................................................................................MPEVIFNGPAGRLEGRYQPSKEKNA-----PIALILHPHPQFGGTMNNKIVYDLFYMFQ-QRGFTTLRFNFR-RSQGEFDHGLSDAASALDWVQAL--------------------------------------------HPDSKTCWVAGYSFGAWIGMQLLMRRPE---------IEGFISVAP-------------------------------------------------QPNTYDFSFLASGLIIHGDQDKV-KDVQALVDKLKTKGITITQKTIASANHFFTG--------QGEELIEECSEYLDRRLAGELVEAR. 219
9 -16.400[R] COG3571 Predicted hydrolase of the alpha/beta-hydrolase fold  ali follow..  19  8...............................................................................................................................................................DGPGDAPVTILLAHGAG---APMDSTSMTAAAMALA-GVGFRVARFEFG--------------------------------------YMAARRTADGRKPRPARKTLNPEYRAAIAELGAQGTLVIGGKSMGGRVASMVADDLHAEG------KIAGLLCLYPFHPPGKPDQL-----------------------------------------RTRHLTDLKPALICQGTRDEFGTRDEVSRYALSD---RIELLWLEDGDHDLKPRKTVSGFSTAKTLAEAVARWADRLA......... 212
10 -16.200[O] KOG2100 Dipeptidyl aminopeptidase  ali follow..  11  487..................................................................................AQMDDQMKTAIVSCKGPAAPHTAIVNLTRMDSDKKTEHANLLYDKTYQNRGLPVIIKETIKISDDDALIKLSIPKDNRDKHQAIPLIVHVYGG---DQNTKEATQIGIEEVVASASQAAILRIDGRGSGGR---VEVEDQIKAIKVVLRLYRHL-----------------------------------------LDARRVAVFGWSYGGFMTLSMVNEAPEQ--------FKCAVSVAPVTNFAY-------------------ATYTERYMGDAPLESYSDVTKKLDNFKSTRL------LLMHGLLD---QNSAILIDELQNRGVDFDLMVYPNQAHSL--------SSRTSHVVGKMTHFLRQCFYTDK..... 799
11 -16.200[Q] COG3458 Acetyl esterase (deacetylase)  ali follow..  10  4....................................................................................FDLPLEELKKYRPERYEEKDFDEFWEETLAESEKFPLDPVFERMESHLKTVEAYDVTFSGYRGRIKGWLLVPKLE---EEKLPCVVQYIGYNGGRGFPHDWLF--------PSMGYICFVMDTR-PRTYYYRRVFTDAVRAVEAAASFPQ-------------------------------------------VDQERIVIAGGSQGGGIALAVSALSK---------KAKALLCDVPFLCHFRRAVQLVDTHPYAEITNFLKTH-------RDKEEIVFRTLSYFDGVNFAARAKIP-ALFSVGLMDNICPPSTVFA-AYNYYAGPKEIRIYPYNNHEG----------GGSFQAVEQVKFLKKLFEK....... 324
12 -16.100[R] KOG4840 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)  ali follow..  30................................................................................................................................................................TSNVTRSLLLFVGG---LGDGLLTVPYVQELVNPLDEIGWSIVQVQTQ---TGSLKRDDEDLHKAVDYFLHI-----------------------------------------GGADFSTRKIVLMGHSTGSQNVLYYLTQSILPN------YLIAGIAQAPVSDREAAYQFNGKEKTKELVDWVKAEYL-NDVLPRSSDLSADDFAKTFGNLKEISGSTAHQLILLMSERDEFVSPSTDKAQLLNRTSNSSLSGIIPGATHNVGPKS---SPEALKWLINQLITALRSFIDQ....... 316
13 -16.100[R] KOG4391 Predicted alpha/beta hydrolase BEM46  ali follow..  15  102................................................................................................................................................................SVSWDTLSCYDLDLRIPDIAH-------EMVRIMIQKLKCNVFMLSYR-YPSQQ--GIIKDAQAALDHLSGRTD-------------------------------------------IDTSRIVVFGRSLGGAVGAVLTKNNPD--------KVSALILENTFTSILDMAGVLLPFLKWFIGGSGTKSLKLLNFVVRSPWKTIDAIAEIKQP-----------VLFLSGLQDEM-FHMKMLYAKAAARNPQCTFVEFPSGMHM-------TWLSGGEVYWKTNLQFLEKYAPEKRKEDT. 333
14 -15.500[I] KOG4667 Predicted esterase  ali follow..  11  57.......................................................................................................................................QEQRIVIPNRHNKLVGLLHETGST-------DIVVLCHG---FRSNKSNQIMNNVAAAIQKE-GISAFRFDFSGNGESEYNHEADDLHSVVQYFSNK----------------------------------------------NRVVPIILGHSKGGDVVLLYASKYHD---------VRNVINLSGRYDLKKGIRERLGEDFLERIKQQGFIDVGDGKSGYRVTEKSLMDRLSTDIHEALKIDKECRVLTVHGSEDEV---PVEDAKEFAKIIPNHKLEIVEGANHGY--------TEHQSQLVSTVMEFIKTVIVKNN..... 309
15 -15.300[R] COG1073 Hydrolases of the alpha/beta superfamily  ali follow..  11  21........................................................................................LAGALMALVGCQTSPAATTSSNTGGTNMQLQLTQEWDKTFPLSAKVEHRKVTFANRYGITLAADLYLPKNRGG--DRLPAIVIGGP----FGAVKEQSSGLYAQTMA-ERGFVTLAFDPS-QPRNVA-INTEDFSAAVDFISLLPE-------------------------------------------VNRERIGVIGICGWGGMALNAVAVDK---------RVKAVVTSTMYDMTRVMSKGYNDSVTLEQRTRTLEQLGQQRYQPPYNELKGGEAQFLMPILTYIKEISPRPILLIHGERAHSRYFSETAYAAAAE---PKELLIVPGASH--------LYDRLDRIPFDRIAGFFDEHL......... 367
16 -15.200[R] COG0400 Predicted esterase  ali follow..  16  7...............................................................................................................................................................KGADPNAPTLLLLHGTG------NEHDLVPLAEMISPGSSILGVRGNVLENGMPRFFRRIAEGVFDEEDLVIRTKEL------------------------------EFLDDAVREHAINRNRLVAIGYSNGANIAASLLYHYEQ--------PLMGAILFKAMV--------------------------------------------PLRNRTVPDLQQMP-IFIGAGKYDPL-TETKELINTLTNAGANVYEQWID-VGHQL-----------TREEVERAKEWFNEQFLEA...... 204
17 -15.000[R] COG4188 Predicted dienelactone hydrolase  ali follow..  5.......................................................................................................MIALSEIEAASEGDINFSALPDPTEMGPYGVAPKETWWLNDQNRRFYVDVYRPQRW--KEGKTPVLVFSHGLA------RPEDFDNAAEKMASY-GFVVALPQHDILQAQALLNRTSRQGYYPTEFIDRPKDISYVIDELERRNASE-----------------------FGDRLNLTQVGVGGHSFGGYGALAVALTLPRSDYDFRDPRVVAVLAANPVNSAIFGVSGLHKVT---------------------------------------------PVLLLGGSYDPFVLEQARSFPRLASR--DKYLTLMEGQAHVDFS-KLPDPNLLHTYGSAVMVPFFQLYVAGDESFRPL 339
18 -14.800[R] COG4099 Predicted peptidase  ali follow..  13  62..GLNPADFHVEGRTVTGVWTSTSTNPADIAPSGRYMIIALSPDDKNATLAEQVQPNSKNNSNKSANGRGGPGNAGDIPAYDTVYRTAQATVLRL---------PSVHTASGDTLPASEKALTTQYVENLIVDDFQQLEFYDEKTGKKLKYNLFIPKDNYSPDKAWPLVLFMHDAGATSDVTRTTLYQGLGAIAWASPEDQAQRPCFVLAPQYE-SDMLDTTIDLINVLSEQYN-------------------------------------------IDKSRIYATGQSGGCMMTIAMNIK-------------------YP-----------------------------DFFAAS-------LVAGQWDPALVKPLAQQK-LWILVSQDDNK-PGQNAIIDVLEKEGVQISRAIWDGTWN...................................... 395
19 -14.600[R] KOG1552 Predicted alpha/beta hydrolase  ali follow..  11  13....................................................................................CPPCPGPIAAKLAFQPPEPTYKLTPADDTNIRYNLQLFDRAEWQYSEREKSKVEAFFTRTSRGNLITCIYVRCSKNAK----YTLLFSHGNAVDLGQM------SFYLTLGSQINCNIFGYDYS-KPSEK--NLYADIEAAWQAMRTRFN-------------------------------------------ISPETIILYGQSIGTVPTVDLASRH----------EVGAVILHSPLM-------SGLRVVFRNTKRTWFFDAF-----------------------SIDKVAKVKPVLVIHGTDDEVID--FSHGIGIERCPKTVEPFWVEGAGHN--------DVELHPHYYERLRKFLSVELVK....... 286
20 -14.600[Q] COG0412 Dienelactone hydrolase and related enzymes  ali follow..  19  24............................................................................................................ATTQQSGFAPAASPLASTIVQTPDDAIVAGFTSIPSQGDNMPAYHARPKQSDG---PLPVVIVVQG---------HEHIRDICRRLALE-GYLAIAPEFREGDPNDFADIPTLLSGLVAKVPDSQVLADLDHVASWASRNGG----------------------------DVHRLMITGFCWGGRITWLYAAHNPQ---------LKAAVAWYGKLTGDKSLNSPKQPVD-----------------------------------IATDLNA--PVLGLYGGLDNSQESVETMRQALRAANAKAEIIVYPDAGHAFNA-RPSYHAASAEDGWQRMLEWFKQYGGKKS..... 292
21 -14.300[E] COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases  ali follow..  16  355.........................................................................................TIAYVKMGPTSPPDIYIYRDDNEYRLTDHNAWFAESRSLAEPVRLQVQSP-----LGGSIDAWILLPPDAGECSGCLPWILYIHGG-----TSYGYAFIHEFQMLASQ-GFAVIYSNPR-------------------------GSDGYSEEFADLRGRYGVDDYSELMKVVDEALSD-------FPQLDPQRGGVTGGSYGGYMTNVIVTKTRRFKAAVTQRSCSNWISFY---------------------ESDIGWYFAPELISAQEPWRDLEKYVDFSPLFSVE----TPLLIIHSTED---SGAIQLFTALKLKGVETRLLVFPGENHN---LSRSGTPKRRVARLRAIASWFKEHLGSQQRG... 659
22 -14.200[I] COG2267 Lysophospholipase  ali follow..  12  2..................................................................................................................................ENSRIPGEHFFTTSDNTALFYRHWPALQPGAKK----VIVLFHRGH------HSGRLQHLVDELAMP-DTAFYAWDARRGYSPSLARSVRDVDEFVRFAASDSQVGLE-------------------------------------------EVVVIAQSVGAVLVATWIHDYAP--------AIRGLVLASPAFKVKLYVPLARPALA--LWHRLRGLFFINSYVKGRYLTHDRQRGASFNPLITRAIA---PTQLLISGDDYVVHRQPQIDFYQRLRSPLKELHLLPGFYH------DTLGEENRALAFEK.................. 274
23 -14.100[R] COG3150 Predicted esterase  ali follow..  13  1.....................................................................................................................................................................MSTLLYLHG----FNSSPRSAKASLLKNWLAEHHPDVEMIIPQLPPYP------SDAAELLESIVLEH---------------------------------------------GGDSLGIVGSSLGGYYATWLSQCFMLP-----------AVVVNPAVRPFELLTDYLGQNE--------------NPYTGQQYVLESRHIYDLKVMQIDPLEAPDLIWLLQQTGDEVLD-----YRQAVAYYASCRQTVIEGGNHAFTGF---------EDYFNPIVDFLGLH.......... 191
24 -14.100[R] KOG3043 Predicted hydrolase related to dienelactone hydrolase  ali follow..  14  30......................................................................................................................................................LDTYAAGSTSPKEKVIVILTDVYG-------NKFNNVLLTADKFASA-GYMVFVPDI-----FGDAISSDKPIDRDAWFQRHSPEVTKKIVDGFMK--------------------------LLKLEYDPKFIGVVGYCFGAKFAVQHISGDGG--------LANAAAIAHPSF---------------------------------------------VSIEEIEAIDSKKPILISAAEEDHIANLRHLTEEKLKDNHATYQLDLFSGVAHGFAAISIPAVKYAKEKVLLDQIYWFNHFSN........ 245
25 -13.800[I] KOG1455 Lysophospholipase  ali follow..  11  14.......................................................................................QKKRKMNIGCGVSPSSPTTTVVDEEVAIRRKLAMRRVLEDNGGDGSSVRDFSLFTTKRGDTLFTQSWTPVD---SAKNRGLVVLLHGLN-------EHRYSDFAKQLNVN-GFKVYGIDWI--------------------------------------GGSDGLH----------PSLDYAVADLVIAENPGLPCFCIGHSTGGAIILKAMLDAKIEA------RVSGIVLTSPAVGVQPTYPIFGVIAPQLSAAKKKIMPVSRDPEALLAKYSDPLVYTGFIRARLQNLNRIKPFLVMHGTADTVTDPKGTQKLYNEASSSDKSIKLYDGLLH------DLLFEPERETIAGVILDWLNRRV......... 333
26 -13.400[Q] COG3509 Poly(3-hydroxybutyrate) depolymerase  ali follow..  14  19...........................................................................................................................SGGTRLAAGFGNGNSVHTLDVDGAGRSYRLYKPVGL---PSSAPLVVMLHGGF---GSAKQAERSYGWDELADSEKFLVA-----------YPDGYHRAWNANGGCCGRPAREGVDD-----------GFVRAVVADIANNVS-----------IDPARVYVTGMSNGAIMSYTLACNTS---------IFAAIGVVSGTQLDPCQSPRPVSV----------------IHIHGTADPLVRYHGGPGAGFARIDGPPVPDLNAFWREVNRCGALDTTTEGPVTADNRRVVLLTVDDAGHRW.................................... 263
27 -12.200[E] KOG2551 Phospholipase/carboxyhydrolase  ali follow..  14  2............................................................................................................................................................APEIHLKPKNPRILCLHGFR---GRILQAGIGKWPDTILRDLDLDFLDAPFPATGKSDVERFFDPPYYEWYQANKGFKEYRNFEECLA------------------------YIEDYMIKNGPFD--GLLGFSQGAFLTAAIPGMQEQGSALTKVPKVKFLVIISGAKIPGLMFGEPKAAVNAFSSPVRC------------------------------------PSLHFIGERDFLKIEGEVLVESFVEP----VVIHHSG--H---------IIPKLDTKAEETMLSFFQSIRQMLSDES. 227
28 -12.000[P] COG2382 Enterochelin esterase and related enzymes  ali follow..  11  130...............................................................................................................................DCPQAPEIPAKEIIWKSEKKSRRVWIFTTGDA--TAEERPLAVLLDGEFWAQSMPVWPVLTSLTHR-QQLPPAVYVLIDAIDTTHRAHELPCNADFELLPLVKAI-----------------------------------------APFSDRADRTVVAGQSFGGLSALYAGLH-------------------WPERFGCVLSQS-----------------YW-------PHRGGQQEGVLLEKLKAGEVSAEGLRIVLEAG-PMIMRANQALYAQLHPIKESIFWRQVDG--HDALCWR------------GGLMQGLIDLWQPLFHDRS. 374
29 -11.900[R] COG4287 PhoPQ-activated pathogenicity-related protein  ali follow..  10  1..........MFKRYLWK------------------------AFALVKRGESMKKIYLVVIVLFFISTKVYTLLHNNIFFCRNSPECDLSHVLPDYREQISGTPLKYTLINTAPLAQVVVRHYELLSQH-------SPDDMVTPAQWRHNVDIYIPETA----KEHHALVVVNNGI--ITGKPGDFPQETLASISRDTNTIVISVS---IPNQYLTFQKEDESVSRSW-------------ALFMEAPEQRKLMPLNIPMVTAISQAMRLAKKELTQWNINSFIITGISKRGWTTWLSA--IADP-------DVEAIVPFAIDLLDIDASLEHIYQSYGGNWPITFYPYYQQGIDEKIKSPAFTQLRQIIDPLRYLNTIYQPPKYIINASGDDF-DNTRFYYSKLPG---VKSLRIVPNMNHYS----------INQFAEGSLVPFINRFQSKKT..... 395
30 -11.700[R] COG4757 Predicted alpha/beta hydrolase  ali follow..  2....................................................................................................................................HTDAFPVSLAAADGYVLGGCRYPADTALK-----GRLVVAGATA-----VPQGFYRRFAQFAGTR-GFETLTFDYR--------------------------------------GQSRPPSLHGLRTDFLDWARLDLAAAVDTMADGAVPLYVVGHSYGGHAFGLLPNHRKVAGFCVFGTGLAMWNAVLPVLTWWKGYCPWKMLGLGEDLPVGVYRQWRHWCRFPRYLFDDPAMRGIEQAYADVRT----PIVAVNALDDLWAPPADAFMQGYRNAPLTRKDLDGGKVGHMGYF------RQAGEPLWERMLGWFSSLPRTTATR... 290
31 -11.500[I] KOG3847 Phospholipase A2 (platelet-activating factor acetylhydrolase in humans)  ali follow..  12  6......................................................................................................................SSPQILTRKMPGQFKVGCMDLMIEEAAGSGLFMRLFFPTDSEIKSDKWPVLVFSHGLG------SRTFYSTYCTSLASH-GYVVAAVEHR-SACWTYKLVEKNGTLVEK--RNDKDQFKIRNEQVGKRAEECAKAVKILEQLDSGNVKDKVIIEFFKNKLLTTTASIIGHSFGGATSIASSSSDFQKAIVLDG----------------------------------------------------------MYPLDQNQQEQAKQPIMFLNVGDWQWNENLEVMRKILPNNEGNILLTLSGAVHQSFTQFGVHGPTEPYLCMQSAIELTLSFLKD....... 355
32 -11.500[R] KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily)  ali follow..  1..........MFQK---TDFLSKIFSSSSHPLTGSQNIVVKDPQTLDFAMQSQNEIVCSLRERSHMNTMSYAQTQMMAIDEIRAFQSEGHLHLKYISLIIAMMAETAVPSKSQRLAEAEGRILSALGIKYLARLIQIPFKNTEISTITVNCE-----SEQPIVKAKYPIVLIHGFG-----AGVALWGSAIKRLAQFQT--VHAFDLPGFGRSSRPKFSSDPETAETEMIDSIEQW--------------------------------------RDKMNLEKMNLVGHSFGGYLATSYALKYPK--------RVENLILADPW---GPSLVRRLRPDLALKYSEDVYDYIYLANSRDPTGEEVFKCLSENLGWAKQPMSK--PVTFIHGERSWI---DWRTTRRLFGELEHVESHIMDSAGH-------HVYADDADKFVQLVIGSLKDGKTGELVPEE. 433
33 -11.200[R] COG1647 Esterase/lipase  ali follow..  12  1......................................................................................................................................................MKITPPQPFLFEKGKRAVLL-LHG------TGSSADVRILGRFLQENNYTCYAPQGHGVSPDLLLKTGPND------WWEDVLAAYDHLKSL------------------------------------GYTEIAVAGLSLGGLFSLKLGFS-----------PLKGIIAMSTPTRMDSSSPIIQG------FLDYVRNYKKLEGKTPEQIDAEMVAYKDAPMNTIAKLKDE-PIMVVQGEKDDMVDVSGAQLIYDTVESTKKELHWFKESGH------VITLDKERKDVNQAILTFLDSLDWQE...... 248
34 -10.800[R] KOG2382 Predicted alpha/beta hydrolase  ali follow..  10  20.....................................................................................................................................................SMMLANLTFGNMRSKGTPLIL-VPG---LFGTKE--NWIQVGKDLSQRLGCMVFAVENR-AASMTYEEMADDLVGFID----------------------------------------------VRKITGEDKVNLHGHSMGGKAVTQLATTMSPLGYPLKRAEYLECIKQMIATDMNKSRSEVMAELGEKVSKVLLYQFVRGNLGEDVNGKAHWICNLNVIDETYIYLLSHDPTLFQRAPGSGFLPA--AHKNRVEKMFPMVQFAETAWSNH--------IHADDPKFFVDSICEFLEEPDQLGMRA... 295
35 -10.700[S] COG4947 Uncharacterized protein conserved in bacteria  ali follow..  13  23.................................................................................................................................................GRDMEYKRYGHAG-------RPVVVFPTSQG---YQFEDSGGVGALAEFIDTGRIQLFTVDHRIGRHEAYFRYVRE--EALPEILSTAS---------------------------------------AANGGRKLKPLFSGCSMGGYHSSNFVFR-------------------FPELASGVISLSGVYSARDFFGKVLDGDIFYNSPLDYLPGIVDPKLLARLK----------ALRLIFCCG-ERMLVETRQLEQILRDKSIPAWVDYWGGD-HDWPWW---------HKQLVYFFGRWLDDDLMHRLD... 267
36 -10.600[R] COG0627 Predicted esterase  ali follow..  10  61.................................................................................................................................................GRDIKVQFQNG------GANSPALYLLDGLR---AQDDFSGWNTTAFEWYYQSGISVV------MPVGGQSSFYSD------WYSPACGKAGCQTYK---------------ETFLTSELPQYLQSNK---QIKPTGSAAVGLSMAGLSALTLAIYHPD--------QFIYVGSMSGLLDPSNAMGPSLIGLAMGDAGGYKAADMWGPSTDPAWKRNDPTV-------NVGTLIANNTRIWMYCGNG-VRTSNIKFQDGYNAGGGHNAVFNFPDSTHSWEYW---------GEQLNDMKPDLQQYLGATPGA... 330
37 -10.500[E] COG1505 Serine proteases of the peptidase family S9A  ali follow..  11  445....................................................................................................................TTAQTIKALPAQFDASKLEVEQKVATSKDGTKIPYFLIHPKGHKHDGKN-PLLLHAYGG---FNLSKLPVYDPLIGKLWLERGGSYAVANIRGGGEF--QRAYDDYFAVAEDLIAKK-------------------------------------------ITSPRHLGAYGRSNGGLLMGVAMTQRPD---------WNAVIVESPLLDMIR-------------YTQLPAGASWIGEYGDPAIPAERAWIEAYSPYKLKAGVKYPLAYITTSTKDD---HARKFAARLDDLKVDNLYFENTDGGHA-----NGADPKANARRWALHYTHLSRQLMDH...... 723
38 -10.300[R] KOG2564 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold  ali follow..  11  52......................................................................................................................................................FRIYRTKQPEKPG---PVLLLLHGGG------SALTWAHFCSEVTSMIHCQCLCIDMR-EDDLSADTLAKDIGDLILKLYPE----------------------------------------------EVPQLFVVGHSMGGAIAVHFAHMALVP-------NLIGITVIDVVEGTAMEAASMQSFLRSRPKYFQSIPNAIEWCIRSGQVRNVDSAKVSMPGQIINCTTN--PKQLLLASIDGLDRT-----LTVGQMQGRFQMQVLARCGH-------AVHEDRPHEVAEVISGYLIRN.......... 386
39 -10.200[R] COG2819 Predicted hydrolase of the alpha/beta superfamily  ali follow..  10  26...............................................................................................................SYAQPDMQPLGPNIADKGSGYYHFRVNDFQSADGARHYRVWTAIPNKAAPPSG-YPVLYMLDGNAVM-----DRLPETLLKQLADHSPPVIVAIGYQTNLPFDLNGRAYD------YTPAPGIDRDDSENNPRFHRKTGGGP--AFRQLLERHIAPQVEQGI---TINSERRGVWGHSYGGLFVLDS--------------------WLSS------------SFFHIYYSASPSLSRDNFVLLNRLTTVKPSLFCH-------------KKLIIMEGSAS-MAELLQKVQETVRTNGVNAALQHYPGLGHGPMFNASFRSA........................... 295
40 -9.890[R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)  ali follow..  12  14......................................................................................................................................................IDIYYEDLGAG-----QPIVLIHG------PLNGDSWEKQVLVLLNA-GYRVITYDRR-QPSSGYDYDAADLHTLMTKL-------------------------------------------------DLQNTVLVGFSMGTGEVTRYLGKYGSE-------RVQKAVLMAPVPPFLLKTNDNPEFNVDVLLGERISNEAIQASWNVAAGASAKGTLDCVPSWLTDFRDDLPPTLIIHGDADPLESTAARLPKRIKNS----QLEIIPGGPH-------AINWTHADQVNPLLLNFLQ............ 276
41 -9.710[R] COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold  ali follow..  14  39.................................................................................................................................RKVKFTPYWQRLELPDGDFVDLAWSEAPAQAQHK---PRLVVFHG---LEGSLNSPYAHGLVEAAQKR-GWLGVVMHFRRMHRIYHSGETEDASWFLRWLQREFGH---------------------------------------------APTAAVGYSLGGNML------ACLLAKEGNDLPVDAAVIVSAPFM--EACSYHMEKGFSRVYQRYLLNLLKANAARKLAAYPGTLPINLAQLKSVRRIREFDPTLIIHAKDDPFMDHQVIPKPESLPPQVEYQLTEHGG--HGFIG----TLLHPQMWLESRIPDWLTTYLEAKS..... 339
42 -9.660[R] KOG1454 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily)  ali follow..  12  81......................................................................................................................................................................SPVVLLHCFD-----SSCLEWRRTYPLLE-QACLETWAIDVL----------------------------GWGFSDLEKLPPCDAASKRHHLFELWKTYIK-------------RPMILVGPSLGATVAVDFTATYPE--------AVDKLVLINANAYSEGTGRLKELPKSIAYAGVKLLKSFPLRLLANVLAFCSSPLSENIDWTNASHIKHIDKTLVVCSENDQIVS--NQLSVKLLCELANAVLREVPDSGH-------LPHVENPKHIVKLISDFASGKL......... 328

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24