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Query: [I] KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLSRVVHRSSSVFRTNLSFRLFSQSAFAVHSTHRVEKQGDVAVMKIDLPNTTENVLNKALFAEMNETLDRLQSDQSVKAIVVMSGKPNSFVAGADIQMFKAEKTAAGVSNLLREGQKQLLTIELSQKPIVAAIMGSCMGGGLEIALACHYRIAVNDKKTLLGLPEVTLGIMPGDGGTQRLPKLTTVQNVLDLTLTGKRIKANKAMKIGIVDRVIQPLGDGICTSTETTHKYLEEIAVQSARELANGKLKINRDKGFVHNATQAVMTSKFVLDNVILKMAKNKLIKLTNGNYPAPLKILDVVRTAYLDPKNGYEAEAKAFGELSQTFQSKALFGLFEGSTNAKKNKYGKGLPVNEIAVVGAGFMGAGIANVTINKGIRTVLLDANQAGVERGQNHVATHLNRQLKRQKISKLEREKIYNHLVPTIDYSAMKNADVVIEAVFEDLPLKHKVIRQIENVVGPNTIIASNTSALPIKDIAAASSRSDKVIGMHYFSPVEKMQLLEIITHDGTSKETLATAAQLGLKQGKLVVVVKDCPGFFVVRCLSPMMSEIVRLLQEGVEPSELDKLTTKFGFPVGAATLADEAGLDVAEHVARYLGTALGPRVHGGSVDLLSELVRAGHKGRKTSKGIFVYGDGAKGSKKVNQEAAKLFEKYKLTPIKSVSSPEDRQLRLVSRFVNEALLCLEEGVISSPSDGDIASVFGLGFPPFWGGPFRFVDLYGAGKLVAAMDRFAGVYESVQFEPCQLLRNHAKSGGQFYSLast
1 -186.000[I] KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase  ali  100  1MLSRVVHRSSSVFRTNLSFRLFSQSAFAVHSTHRVEKQGDVAVMKIDLPNTTENVLNKALFAEMNETLDRLQSDQSVKAIVVMSGKPNSFVAGADIQMFKAEKTAAGVSNLLREGQKQLLTIELSQKPIVAAIMGSCMGGGLEIALACHYRIAVNDKKTLLGLPEVTLGIMPGDGGTQRLPKLTTVQNVLDLTLTGKRIKANKAMKIGIVDRVIQPLGDGICTSTETTHKYLEEIAVQSARELANGKLKINRDKGFVHNATQAVMTSKFVLDNVILKMAKNKLIKLTNGNYPAPLKILDVVRTAYLDPKNGYEAEAKAFGELSQTFQSKALFGLFEGSTNAKKNKYGKGLPVNEIAVVGAGFMGAGIANVTINKGIRTVLLDANQAGVERGQNHVATHLNRQLKRQKISKLEREKIYNHLVPTIDYSAMKNADVVIEAVFEDLPLKHKVIRQIENVVGPNTIIASNTSALPIKDIAAASSRSDKVIGMHYFSPVEKMQLLEIITHDGTSKETLATAAQLGLKQGKLVVVVKDCPGFFVVRCLSPMMSEIVRLLQEGVEPSELDKLTTKFGFPVGAATLADEAGLDVAEHVARYLGTALGPRVHGGSVDLLSELVRAGHKGRKTSKGIFVYGDGAKGSKKVNQEAAKLFEKYKLTPIKSVSSPEDRQLRLVSRFVNEALLCLEEGVISSPSDGDIASVFGLGFPPFWGGPFRFVDLYGAGKLVAAMDRFAGVYESVQFEPCQLLRNHAKSGGQFYS 755
2 -76.800[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  32  2...............................................................................................................................................................................................................................................................................................................................................................IKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMSDEDRKRALSLIKGSGDINDLAQADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSLSITRLASATDRPERFMGIHFMNPVPVMKLVELVRGIATEEETFKAAKEFVAHLDKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGGTVDAIDTAMKGANHPMGPLQLADFIGLDTCLSIMQVLHDGLADS-KYRPCPLLVKYVEAGWLGRKSGRGFYDYRGEVPV....................................................................................................................... 287
3 -75.700[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  31  1..............................................................................................................................................................................................................................................................................................................................................MLSSTCTAAVRTAQLSKINNVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQGIANSLKRVAKKKHADDAAASSVLDRIKMSTNVSDVKDADLVIEAIVENIDIKRKLFAEVEVAAKPTTLITTNTSSLRLADIGLNLKDKSRFGGLHFFNPVPMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTVACKDTPGFIVNRLLVPYMFEALRLYERGASMEDIDVAMKGAGYPMGPFELSDYVGLDTCKFIMDGWHAQYPEEVAFTPSPLLNSLVDSGKNGRKSGEGFYKYK............................................................................................................................ 309
4 -49.500[I] KOG1680 Enoyl-CoA hydratase  ali follow..  27  1............................MITLSRTGAAENVALITLNRP-SALNALCRELMLELSENLLKVEKDQSYHVIVLT-GSEKAFAAGADIKEMAKLEFAD---VFENDYFTNWDTLSHITKPVIAAVNGFALGGGTELALMCDIVYAGEN--AIFGQPEITIGTIPGLGGTQRWPRYVSKSVAMEICLSGDRLGAQEAKEDGLVSKVFPVQQLV-------------GEAVLLADRIAKNSPLIVKTVKRS------------------------------------------LNSAYQTSLNQGLEMEKQLFQSTFATNDRREGMSAFAEKRA............................................................................................................................................................................................................................................................................................................................................................................................................................... 250
5 -48.500[I] KOG1679 Enoyl-CoA hydratase  ali follow..  29  1...........................................................MVETFNDVLEDIKKDNGSRVVVLRSLSPGIFCAGADLKERKGM-TPEEATEFVKELRGLLIAIEQLPMPVIAAVDGAALGGGLEMALACDIRTAASD--TKMGLVETRLAIIPGAGGTQRLPRILSPALAKELIFTARVFNGAEAKDLGLVNHVVKQNETQDAAY---------QQALKLAEEILP------------------------------------------NGPVGVRMAKLAIDKGMQVDLATGYSIEEICYSQVIPTKDRLEGLAAFAEKRK............................................................................................................................................................................................................................................................................................................................................................................................................................... 227
6 -45.800[H] COG0447 Dihydroxynaphthoic acid synthase  ali follow..  17  16......................IDHSEGYSDIRYHKSTDGIAKITINRP-EVRNAFRPQTVKEMMTAFSDARFDENIGVIVLTGEGEKAFCSGGDQKVRGDYGGYKDDSVHHLNVLDFQRDIRSCPKPVVAMVAGYAIGGGHVLHMLCDLTIAAEN--AIFGQTGPKVGSFDGGWGASYMARLVGQKKAREIWFLCRQYNAQEALDMGLVNTVVPYAD-------------LEKETVRWCREMLRNSP--------------------------------------------AIRCLKAALNADCDGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRA............................................................................................................................................................................................................................................................................................................................................................................................................................... 275
7 -44.500[I] COG1024 Enoyl-CoA hydratase/carnithine racemase  ali follow..  21  6..............................KDIIYEEKGQVAWVTLNRPAT-YNAFTPVMNREVTVALKKANQSDAIRAIVLT-GTGRAFCSGEDLDGVTVDTDHGA--ILRARYHPMMQGMKQVEKPIIAAVNGTAAGAGMSLALAADFRLVHEN--AKFVSAFLGVGLIPDSGFLYQLPRMIGYAKALELAVLGKPLSAEDAQRCGLVTEVFAADEWE-------------DGVASFSMKLAALPTKAIGLIKRL------------------------------------------MIDGMNEGFLEVLEKEAQAQRIAGQSADHREGLEAFKQSRP............................................................................................................................................................................................................................................................................................................................................................................................................................... 254
8 -39.400[I] KOG0016 Enoyl-CoA hydratase/isomerase  ali follow..  17  50......................LTESASTYRDIVVKKEDGFTQIVLSTRSTEKNALNTEVIKEIVNALNSAAADDS--KLVLFSAAGSVFCCGLDFGYFVKHLRNNASLEMVDTIKNFVNTFIQFKKPIVVSVNGPAIGLGASILPLCDLVWANEK--AWFQTPYTTFGQSPDGCSSITFPKMMGKASANEMLIAGRKLTAREACAKGLVSQVFLTGTFTQEVMIQIKEASYNPIVLEECKALVR--------------------------------------------------------CNIKLELEQANERECEVLRKIWSSAQGIESMLKIPLLGYKA............................................................................................................................................................................................................................................................................................................................................................................................................................. 313
9 -28.300[I] KOG1684 Enoyl-CoA hydratase  ali follow..  15  1.....................MALSVRQSSSSVLATESSNKGMIILNRP-KALNAINLEMVRKIYKHLKKCEKSKSL--VIIKGTGDKAFCAGGDVRALVEAGPTDESKSFFREEYSTNALIGNYKIPYIAIIDGITMGGGVGLSVHGKYRVASD--RTLFAMPETAIGLFPDVGGSYFLPRLQG-KLGLYLGLTGYRLRGADVYYSGIATHYCESSDLETALLNCPDADDVPELLQKYHSPPEKPFSLQPVLEQINKNFSADSVEGILENLQNDGSEWAKKTLETLSKMSPTSMKVTQLELGSQLSLAQCLIMEYRLAVRHLERSDFKEGVRALLIDKD--QKPQWQPTKLADV................................................................................................................................................................................................................................................................................................................................................................................................................ 331
10 -22.100[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  11  6.........................................................................................................................................................................................................................................................................................................LAILGAGCYRTHAA----ITNFSRACEVAEMVGKPEIAMTHSTIT---------MGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKGAIHFTHPEDLGFEITTDDR-EAVADADFIMTWFPKG-DMQPGIIDKFIDDIKPGAIV-THACTIPTTKFYKIFEEKHETLNVTSYHPGPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPELLGPVCDMCSALTAITYAGILS------YRDSVTQVLGAPAGFAQMMAKESLEQITALMEK-VGIDKMEEHLDPGALLGTADSMNFGASADIPTVFEILEKRKK....................................................................................................................... 347
11 -9.050[H] COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase  ali follow..  16  6........................................................................................................................................................................................................................................................................................................................HAEIAKFEALAHR-DRESEFKPLHDINPLRVNWIDERAGLAGKKVLDIGCGGGILSEAMAQRGASVTGIDMGEAPLAVARLHQLE-----------SGVAVDYRQITAEQMAEEMP-GQFDVVTCLMLEHVPDPASVIRACHRLVKPGGQVFLSTINRNPKAYLFAVIGAEYILGTHFIRPSELGAWSR.............................................................................................................................................................................................................................................................. 193
12 -9.050[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  8  1.MAETLITKPPLSLSFTSLSSMLPSLSLSTANRHLSVTDTIPLPNSNSNATPPLRIAIIGFGNYGQFLAETLISQGHIGVSYFTDLHDLCERHPDVVLLCTSILSKTLPFQRLRRNTLFVDVLSVKEFAKTLLL-QYLPEDFDI-LCTHPMFGPQSVSSNHGWRGLRFVYDK-----VRIGEERLRVSRCESFLEGCEMVEMSVTD----DKFAAESQFITHTLGRLLGMLKLISTPINTKGYEALLDLAENICGDSFDLYYGLFVYNNNSLEVLDLAFEALRKELFSRLHGVVRKQSFEGEAKKVHVFPNCGENDASLDMMRSEDVVVK------YEYNSQVSGSVNDGSRLKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSY-----------------------FSDLDDLFEEHPEVIILCT--SILSTEKVLESLPQRLKRSTLFVLSVKEFPRNLFLQTLPQDFDILCTHMFGPWNNLAFVFRIGMDDRRKSRCNSFLDIFAREGCRMVEMSCAE----DWHAAGSQF-GRLLEKLSLESTPIDTKGYETLLKLVENTAGDSFDLYYGLFLYNPNAMEQLERFHVAFESLKTQLFGR........................................................................................................................................... 617
13 -9.050[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  10  38................................................................................................................................................................................................................................................................................................................................................................KKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEK------------------RASFQRATENGFKVGTYEELIPTADLVVNLTPD--KQHSKVVADVMPLMKKDSAFGYSHGF-DITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQY----ETITEALKQGGITLMMDRLSNSAKELAEQIKESLGFLYYKHMDDIISGHFSATMMADWANGDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMI-----------AMVKAGVELAFDAMVASGIYEESA--ANTIARKRLYEMNVVISDTAE-YGNYLFSN................ 426
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;