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Query: [TZR] KOG1704 FOG: LIM domain, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSERIRRRRLEASEQFAPQLISSRRAQGGLSPASRIRIAADAHRHSTSDDDSGCALDEYAWVPSGLKPNMVHAYFACLPENKVPFIGSAGEKWRQRQSRYQLPPQDSDVRYCEDLNAEEADTLRMFERTRKTECLGSGVVQYAPFDTKCEKMLQGSPDIKFQLPKLKRPPIKMQYDSNIFDFQVIFGDECLEAEGRSWHFHHFQCAQCNDVLADQKYMQRANKPVCLKCFHSSSSTFSCTTCRLSFSSDTPHMSQGDLHWHASAECFCCCVCSKNLLGVKYSRVGESLFCGYQTCGGEDEELLDEDRLGSPHRKVTQKSTKVVRIPASPRVAPRHPHVIQQNLTTTMTIQKPSVVIQNQRPKPPQRAPPPPPSENIYETVLPCSSNNSPNFDKKYSHELPTSPNHHNYYSKTPNNLLTGYPEMDGYSTSSSSDSDDEQLYISNIMAAASLSRVPAKSSSRKSKKNEPMMMSGGGVRMAKKKKSSRCTVSLast
1 -137.000[TZR] KOG1704 FOG: LIM domain  ali  100  1MSERIRRRRLEASEQFAPQLISSRRAQGGLSPASRIRIAADAHRHSTSDDDSGCALDEYAWVPSGLKPNMVHAYFACLPENKVPFIGSAGEKWRQRQSRYQLPPQDSDVRYCEDLNAEEADTLRMFERTRKTECLGSGVVQYAPFDTKCEKMLQGSPDIKFQLPKLKRPPIKMQYDSNIFDFQVIFGDECLEAEGRSWHFHHFQCAQCNDVLADQKYMQRANKPVCLKCFHSSSSTFSCTTCRLSFSSDTPHMSQGDLHWHASAECFCCCVCSKNLLGVKYSRVGESLFCGYQTCGGEDEELLDEDRLGSPHRKVTQKSTKVVRIPASPRVAPRHPHVIQQNLTTTMTIQKPSVVIQNQRPKPPQRAPPPPPSENIYETVLPCSSNNSPNFDKKYSHELPTSPNHHNYYSKTPNNLLTGYPEMDGYSTSSSSDSDDEQLYISNIMAAASLSRVPAKSSSRKSKKNEPMMMSGGGVRMAKKKKSSRCTVS 489
2 -54.400[TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved in axon guidance  ali follow..  12  6...............................................................................................................CHGCGE-----------FVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNSSSPKETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPYCEKDYQGLFGV-KCEACHQFITGK--VLEAGDKHYH--PSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEKLRSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYDDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSLPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHRALAAQSKSSEDIIK 394
3 -48.100[TZ] KOG2272 Focal adhesion protein PINCH-1, contains LIM domains  ali follow..  13  40.....................FRPFQDGIFYEFEGRKYCERDFHVLFAPCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCA--------------KELADCGFIKNQNRALCHECNAKVKAECQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSCLRCHDKMGIPICGACRRPI-EERVVTALGKHWHVEHFVCAKCEKPFLGHRHYEKRGLAYCETHYHQLFGN-LCFVCNQVIGGD--VFTALNKAWC--VHHFACSVCDTKMTQKSFYEYDEKPVCKKCYDRFPNELRRRLRT...................................................................................................................................................................................... 325
4 -41.700[T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins  ali follow..  14  397...............................TKKMLYDMENPPADEYFGRCARCGENVVGEGCTAMDQVFHVDCFTCIICN--------------NKLRGQPFYAVEKKAYCEPCYINTLEQ--------------------------CNVCSKP------------------------------IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVAGGLIHCIEDFHKKFA-PRCSVCKEPIMPETVRIVALDRDFH--VHCYRCEDCGGLLSNQGCYPLDGHILCKTCNSARIRVLTAKAST...................................................................................................................................................................................... 610
5 -40.400[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  15  28...............................................................................................................................................................................PQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLAD-RCFSRAGSVYCKEDFFKRFG-TKCTACQQGIPPTQVVRKAQDFVYHL--HCFACIICNRQLADEFYLMEDGRLVCKEDYETAKQNDDSEATAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKE--KRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIA.... 342
6 -39.100[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  11  1.............................................................................................................................................................................MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNL-SEKCFSREGKLYCKNDFFRRFGT-KCAGCAQGISPSDLVRKARSKVFHL--NCFTCMVCNKQLSEELYVIDENKFVCKDDYLSSSSLKEGSLNSCTDRSLSPDLQDALQDDPKETDNSTSSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQ----FQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTPYTYYGDYQGDYYAPGSNYDFFAHGPPSQAQSPADSSFLAA 315
7 -17.300[K] KOG2461 Transcription factor BLIMP-1/PRDI-BF1, contains C2H2-type Zn-finger and SET domains  ali follow..  9  483.................................................SSSHNDSSFNGVPNYVQQQENGKTRYACKDCNK--------TFGQLSNLKVHVRTHTGERPFCEICTKEFTQLAHLQKHHL---------VHTGERPHRCDICDKRFSSTSNLKTHLRLHNGQKPYT-CDVCDAKFTQYVHLRLHKRL-HAN-YSCGTCGKKYISPSGLRTHWKTTEDMKDSMRDIKGEIDEGSMSGSGYGNLGIFEN---LNSELKRPLMPIETNLPNASLLGQGPSGMAPPPTSQQQQHMMYGNTMGHMGQGSPPPQHFQMDHSGMQNGGGIPHQHQLIQG................................................................................................................................................... 780
8 -16.300[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  10  1MQNGKPRSSARPSFHRRPKDGVANTTTDNAAVKPEA---LESYTGNDDNACVVCFKNV------SIGDCDHPVCYECS--------------TRMRVLCQQ--------NECPICRHVLSKVLFTLDKLPYRELEANNRSDLYSKKY----------RIGFCTAEIRQQFFKLLDHPCPKCDAPPYRTEGLRNHVRSEHKLLY-CDLC---VETLNIFTFERRCYTQAELQLHNGHPLCEYCNKRYVDRDELFR------HLRREHYFCHFCDADGCNEFY-FRAEHFLCEEGKCATEQFVGAFRNEIEYKAHVANVHGKSLNKQQAKQTRTLQVEITLGPRGRSGQTEQGITSVRTRNDEHNDYQNDLPSITQRHVSIDAGNEEQFPTLRGASTAPSVSLVRPPPPSMRNLSGTSGLARTKENFPALGGGNGGGVTGPTSSSIAARAAQSQHPVAAVFKKPTSAAGSGSRSGPPGNGMLLHVSNRSAA 461
9 -15.800[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  12  1..........................................................................................................................................................................................................MPCESC-----GVEFTVFRRKRACFDC-----KRYYCANCIAS----------------------RCKRCRTDLLKLKYLQSKH---ISTEGCLEKEELVG--THVAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFSNLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQATTTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSDCECSDEEIMATFSERVSISLKTDTSGRRVN 269
10 -14.800[O] KOG0802 E3 ubiquitin ligase  ali follow..  8  342.........................................................................................................................................................................................LHAALPDATSEELRAYDDECAICREPMAKAK------RLHCNHLFHL--------GC---------------RSWQGLNEVYSCPTCRKPLFVG-----------------------RTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQVNFKCILDYL.. 594
11 -14.500[R] KOG3608 Zn finger proteins  ali follow..  11  130...............................................................................................................................................GQNFRCTDCEREFVSIVEFQDHIVKHALFEYDIQKTPEDEKHMGNKYRLIEHISTHSN-VACFHCGELFRTKTTLFDNTNSFCAQCVVRHVNCYKCTMCDMTC-SSASSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVCEHPDCHRTYTQMRRHFLEVHGNNPILYACHCCERFFKSGKSLSAH.......................................................................................................................................................... 368
12 -14.400[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  11  767...............................................................................................................................................................................................EGLDLHYWKHC-RCDHCKQVVE-TEHLLTE----CDK--KDGFG--KCYRCSEAVFKEE----------HKHKDC--CPLCHENFSPKAHLMGPAG--CTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLSKS....................................................................................................................................................... 917
13 -13.800[R] COG5048 FOG: Zn-finger  ali follow..  13  550..........................................................................................................................................................................................................FECLGCTKTFKRRYNIRSEDRPYCDKAFVRN-KAYACP-CGKKFNREDALVVHRSRMICSGGKKYENVVIKRSPRKRGRPRKDGTSSVSSS.................................................................................................................................................................................................... 664
14 -13.800[R] KOG3002 Zn finger protein  ali follow..  17  52.......................................................................................................................................................................................................YELLECPVCTNLMYPPIHQCPNGHTLCSSCKLRV--QNTCPTCRYELGN-QDIFPYYSKLKHEQ-HCYSCSECS........................................................................................................................................................................................................................ 153
15 -13.800[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  19  273....................................................................................................................................................CDFCLG----------------DSKINKKTGQPEELVSCSDC----GRSGHPSCWQCIECK---------------CCNICGTSENDD--CDDC--------------DRGYHM--YCWSCHLCLD....................................................................................................................................................................................................................... 376
16 -13.800[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  7  1MSESVKENVTPTRNFRRTQGPQNNTKPHNDRKNFRRKQKKNNLSAEPNLTTSS-------------ADDTDEENELCVICARKLTYVSLTP----------------HHKTCHICGFRQRA-----------------------NKKSCLICRTENEEVMFTSEEVATETLNLLKFFCPLSKDE--VCDFGSFKKYNEHLKCLICATHKHAFPCELEIFTQNQL------EGFKGHPMCAFCSGKRFYSDDELYI-----HMRNQHEKCHICDKMNPASPQYFKHSHYVCTVQTCLDNKFVVFKDELELQAHILQEHGNILKGKPKFFQSELSTFISAPSRVIRERDDYDLPSISSLPGSSSGSRTDVRSASSPEESRLRLAERAKYYLENSKEDFNKFSSYNEDYSKGRLSAEKLLESYKLTKPNADVYLLIHNLAETFPKNSSKYNNLNAIYEQREQTLARQTSLPSLSSDSSLSMSIGRGH..... 476
17 -13.500[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  11  62...................................................................................................................................................KCNNCSQR-----HLKKDCPH-------------------IICSYCGATDDHRHC-QCSKCDEV----GHYRSQ----CP----HKWKKVQCTLCKSK---------------HSKERC-YCYNCGG----KGHFGDD----CKEK--------------------------SSRVPNEDGSAFTGSNLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLPRPSHKRHSQNDHSHSGRNKRRASNFHPPPYQKSNVIQPTIRGETLSLNNNISKNSRYQNTKVNVSSISENMYGSRYNPSTYVDNNSISNSSNYRNYNSYQPYRSGTLGKRR....... 344
18 -13.500[K] KOG2462 C2H2-type Zn-finger protein  ali follow..  9  116...............................................................................................................................................EDEHICPECGKKYSTSSNLARHRQTHRSIMDKKHCPYCEKVYVSMPAYSMHVRT-HNQGCECQFCGKRFSRPWLLQGHIRTHTGE------KPFKCGVCEKAFADKSNLRAHIQT--HSNTKPHTCARCGKAFALKSYLYKHEESSCM--------KNRGGVPGSGAASGNRPPSSPKRQQAEVTSGTISALAP----------GSPAAAVCAASDSAKSTLANKLLQKEKDRRQAAMAFQGFPAGPEVTAYSHATSAQEEYEKFKRINPKVMPHRVPSLYQDLLPNRHVPLALPLAMPYHFQGQATSTGQSDQEQPVDFSPKNNFTHSAKTSPFELTNYAMV... 441
19 -13.100[R] KOG4377 Zn-finger protein  ali follow..  17  320......................................................................................................................................................................................................H---FHCNDCHYSFCDKTRFVQHTARHCGV-SSRKTSHFHCRKCDYVCTDSNKVVAHRRL--HLRQDCYHCVTCDGGVLSRAQLAAHKHRT........................................................................................................................................................................................................ 482
20 -13.100[S] COG4306 Uncharacterized protein conserved in bacteria  ali follow..  12  14.........................................................................................................................................................................................................HVATTAADQK-------HELWEAFCSHSGEATILQ--YPKCSASIRGDDYVEGVLGFGGDYEPPTF-CNNCGSRF..................................................................................................................................................................................................................... 78
21 -13.000[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  10  348...........................................................................................................................................................................................................ICIICMDELIHSP--KKPKRLPCGHILHL--------SC---------------KNWMERSQ--TCPICRLPVF---------------------------------------------------DEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQHI.............. 551
22 -13.000[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  16  190............................................................................................................................................................................................................CPVCGSVSSMVQIGTTQGLLHCNLCETEHVVRVKCSNCEQSGKLHYWSLDDEQAAIKAE----SCDDCGTYL..................................................................................................................................................................................................................... 262
23 -12.500[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  12  40............................................................................................................................................................................................................CPVCGDKVSGYHY----GLLTCESCFKRTVQNYTCQNC----------IDKTQRK--------RCPYCR--------FQK-----C----SVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEK.... 292
24 -12.100[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  7  192...........................................................................................................................................................................................................LCSVCQRGHSPLS----NRIVFCDGCYHQL--------CHHP---DDATVQDVDAEWF-------CMKCQYR-QDLGLSESDKKMYLSSLPTPHLADLILFCEKSYPSLPIYNPRTRELLGEIRHQLLVSSERQQISLQERLHAKQDEAPSDEPAPVPYTASYVANSGTLYDYPTLIRLAIRNT------LSPSKDEIFNWLAQNVPLLPTFHDSASEAIRWMVNKGQLVRSGS---IYQIATVEEYPHLQPSLLPTFQRNRKVPKLVPVSFPTDDPQNLCATVL. 461
25 -12.000[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  10  112........................................................................................................................................................................................................GFFDCNICLEKAEDPILTC------CGHLF--------CWGC---------------YQLLIYLNIKECPVCDGEVTDAEVIP----IY-GNGDDCDGTKPKLEDCGISLPPRPNAKRVESVRQKIINRG-ALAQGDEFGLTNIINNGGDNGGQQQQQQHHHHHHPPFGPLRLLPPYATFPGLLVDTSDIPAPFDDDAFDVDSFVDTTSLRRNRRRPSPAVRASYQRNRSNNASQTISFRLGSSASSAPREFAVPSSSIMTRSQTVNPTEVVTSSTSASSSRRRTEDVN 392
26 -11.800[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali follow..  10  7...............................................................................................................................................................................................TYNRQNWEDAEFLCQTC---LGDNPYV---------RMIKERFGK-ECKICTRPFTI----------RWCPGKKTEICQTCAR--------LKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDGTEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDPLCEQNIKDRYYGRNDPAEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIALVPRQQ-VQYTKRNAAELAAER 284
27 -11.800[R] KOG4299 PHD Zn-finger protein  ali follow..  25  266............................................................................................................................................................................................................CSACHG----------PGNFLC------------CETCPNS--------------FHF--TCWYCNEC......................................................................................................................................................................................................................... 309
28 -11.700[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  9  3...........................................................................................................................................................................................................LC-KCPKRKVTNLFCYEHRVNVCEFCLVDNHPDPNCSLCKTTLAEGDTIRLNCLHLLHW--KCYRCPCCSQEVF-------------PPINEVSPLIEKLREQLKQSNWARAALGLPTLPELNRPVPSPAPPQLKNAPVMHKEVPVHNNRSSTPATHLEMEDTASYSVSNNDVTFARKKNYGAESSSDTRPLLQLRDADNEENKYKRRPTMDWMRGAKHGGSGVPQERASAKKIALFVIFLAVLALI-MKRAGYSGEHSSDPLFDPMANPNIRVAVEDSRLPHV.. 309
29 -11.600[R] KOG3183 Predicted Zn-finger protein  ali follow..  11  26..........................................................................................................................................................................................................FTCDRCLQVYCLDHRSYMKHD--CPKGNRGDVTVVICPLCAKGVRLNPDEDPNITWEKHVNTDCIKCRDCSID-------------HCPDHSCSGPKKPESSFSFMGFLSTNTKEAPASSSSSSRWSSLFASAEASISRLGNDISQKLQFASGNDGNSEKTQERNGKQNCGK................................................................................................................... 216
30 -11.600[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  10  12........................................................................................................................................................................................................ACLSCSICDNIL-------RDATTISEKCIYEKITEDECPVCNIDLGSTPLEKLRPDHNL-------------QDLRAKIFALKRRK--------VKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFTQNKRQSKKSCKESISNKENKDGDEPWDSKMDWKPLNFLVEVANGTKPLKSSASQGSGSKSEHANVSRNQFQGSKTKTKNKKRKCKREDDKSNNGDPTTSETVTPKRMRT.... 271
31 -11.500[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  18  845..........................................................................................................................................................................................................LKCGVCFDRPKE-VVIVKCYHLFCQQCIQRSLEI-KCPGCGTAFGQND............................................................................................................................................................................................................................................... 893
32 -11.500[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  21  22..........................................................................................................................................................................................................KECAVCYSEMILPTTIPSCGHKFCFICLKGVSVSGDCPICRGPIDSQ................................................................................................................................................................................................................................................ 70
33 -11.500[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  9  4..........................................................................................................................................................................................................FQCDDCGENL-------KKPRL-CTAT------KFSCIDCGNMF-------GQVSVHYHN--QCWFCSLCNATMTCEQDYFAHVY---------------KKHQEKANEVADMDYSKQQSEHPAVDKNNLTQQPDLDIYVGLSNDYPWFCSLCDINATSEQTLLAHANGKKHRVKVERFDAEQQKRQSTQHSTVDK-----KDYSKQQIEVDINVGLSNCYPWFCSLCNVKATCQQNLLSHANGRKHRENVELFDATQQQQLEKTTVDKKDTTVNASDGNSEQKKVD 288
34 -11.400[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  18  289...........................................................................................................................................................................................................LCVVCSTNPKEIILLP------CGH---------LCEDCAQKISVT-------------------CPVCRGSIVSAAFIA.............................................................................................................................................................................................................. 338
35 -11.400[C] COG0348 Polyferredoxin  ali follow..  13  195..........................................................................................................................................................................................................GWCGHCGAAYGGLFRIKVEHRQQCDNC--------DCNVCPEPQVLRDPLHAKKSES--LSKDCISCGRCIDV--------------CPEKVFIFTTRFNHSVNHSGE................................................................................................................................................................................... 291
36 -11.300[O] COG0068 Hydrogenase maturation factor  ali follow..  10  46........................................................................................CGDEGALTEFVARLQQECPPLAKINELIRTPYQGELN--FVISHSVSGVVRTEITPDAATCPECQR----------------------------------EIFDPFSRFYRYPFTNCTHC-----GPRLSIIRAIPY-DRCNTSMSAFVMCPECED------SYHDVENRRFHAQPVA--CHTCGPKAERADGKPVTASMFSMLDDVDAVCTLLQKGEIVAIKGIGGFHLACDATQEAAVEKLRQRKRRYDKPFALMARDINVIEKYCFVNDRERELLVSPAAP-------IVLLEKRTEEISSFPIASTVAPGQNTLGFMLPYTPLHHLILKRMNRPIVLTSGNIADEPQCVANDEAKEKLSHIADNREIVNRVDDSVVRVIDNKIQIMRRARG...... 393
37 -11.200[R] KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger  ali follow..  22  115...............................................................................................................................................................................................DPSNFTIHDA-VECDGCGLPLIGFRY--------CVQCSNYDL----CQKC-----------ELAHKH-HL................................................................................................................................................................................................................................... 164
38 -11.100[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  28  275..........................................................................................................................................................................................................FACFICREPFVDPVVTK------CKHYF--------CEHC---------------KHHTKNKK---CFVCNQPTMG................................................................................................................................................................................................................... 320
39 -11.100[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  16  243...........................................................................................................................................................................................................ECPVCLLSIQTPTACSVSGYVFCWKCIVSHMEHGTCPVTHYPISLDDLVRIYET........................................................................................................................................................................................................................................ 297
40 -11.000[O] KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase  ali follow..  17  79.........................................................................................................................................................................................................CFACQDCPEA--------KDNVSICFRC-KGPLKFAKCFICHEN---------------HLSGQC-CCKFCSSV----HHLAKD----CDQ..................................................................................................................................................................................................... 168
41 -11.000[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  20  264..........................................................................................................................................................................................................YKCPICMDSVSKREPVSTK----CGHVF--------CREC-------ETAIRATHK----------CPICNKKLTARQFF----RIY........................................................................................................................................................................................................ 318
42 -10.900[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  14  228...........................................................................................................RHVICLDCFHLYCVT-----------RLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNR-----QQYGAEECVLQMGGVL------CPGCGAGLQRKVTCEGGNGLGCGFAF--------CRECKEA--------------YHEGECS--CPRCHVPVEKNG-----MHMKCPQPQCR................................................................................................................................................................................................. 414
43 -10.900[R] KOG1313 DHHC-type Zn-finger proteins  ali follow..  12  6..........................................................................................................................................................................................QGSFVATINEDYEA---ICWGCGLNLVLPSYAPVFKCGWCGTFILVAFKCA-CNYCS---------KPKSPRTHH----CRTCGMCVLDM------------HCPIGNCVGAGN............................................................................................................................................................................................. 163
44 -10.800[U] KOG4173 Alpha-SNAP protein  ali follow..  16  80..........................................................................................................................................................................................................FACQGCCQVFDALDDYEH---------HYHTLHGNVCSFCKRAF-PSGHLLDAHILEWHERQDMYQCEGCTEKF..................................................................................................................................................................................................................... 155
45 -10.700[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  22  278............................................................................................................................................................................................................CVVCLSDLRDTLILP------CRHCL--------CTSCADTLRYQAN----------------NCPICRLFPGPPADPGGAEE.......................................................................................................................................................................................................... 331
46 -10.700[R] KOG2789 Putative Zn-finger protein  ali follow..  11  149.............................................................................................................................................................................................................MEC---------------PICFLYYPSNFNYTRC--CAQPI-----------------SECFVCPYCMTERFGVIYKPNPKL---PFSFNNNPDTLPSNIAPMGTLSKSSLPLHHIPWPPNQHIKFAHDDKNVVSTDFIHPDWQYKLERARRRALRRAANAT----------------------LLNSHLLETGPANANANHNTDLSHDPTSHGGPRRTLSSRRQHYLANVEQLMLAEAIRQSLLDAQSNDSTNSLPSTEVSQPDSTNISNEQEIVQPQ..... 400
47 -10.600[R] KOG2785 C2H2-type Zn-finger protein  ali follow..  9  1.........................................................................................................................................................................................................................................MATYTCITCRVAFRDADMQRAHYKTDWHSKGSATYCTVCSKK-----FASFNAY-----------------ENHLKSRRHVELEKKAVQAVNRKVEMMNEKN----------LEKGLGVDSVDKDAMNAAIQQAIKAQPSMSPKKAPPAPAKEARNVVAVGTGGRGTHDRDPSEKPPRLQWFEQQAKKLAKQQEEDSEEEEEDLDGDDWEDIDSDEELECEDTEAMDDVVEQDAEEEEAEEGPPLGAIPITDCLFC 257
48 -10.600[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  9  235............................................................................................................................................................................................................CVIC---LED--F--IEDDKLCSHPYHT-----HC------IDP-----------WLTENR--VCPICKRKVFTKGEARASRS---NGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENALLASTVRPATSSGAHERINPFDRAPNLPAHLAEQLTESRRSVWSRINFASFFRRQPAVISVAAPPYLERVESGTSAMGLPVTGTIAVASPASNNILNPNLSGSFKDATVDDSAFLQTPTQGGIGVAALPHSASDRQFLI. 536
49 -10.600[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  21  252..........................................................................................................................................................................................................FVCLICKKDYRSPIATT------CGHHF--------CEQC---------------TRYRKTPT---CIQCGADTKG................................................................................................................................................................................................................... 297
50 -10.600[R] KOG1819 FYVE finger-containing proteins  ali follow..  14  562....................................................................................................................................................................................................RWVPD--QCTACSMP------------------FNFVRRRHHCRNCGRIF----------------------CHKCSCNTISIPEHGYDRKPVSSPQSNLSLLTRQDQFSCNLLHQSHHIHHLFNRSLVPHT................................................................................................................................................................. 656
51 -10.500[T] KOG3575 FOG: Hormone receptors  ali follow..  22  36............................................................................................................................................................................................................CKVCGDRPNNDRY----GASACLGCFRRAVVKYKCQNCL---------ISCTYRN-----ACRYCQKC......................................................................................................................................................................................................................... 96
52 -10.400[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  21  12...........................................................................................................................................................................................................KCPLCQADRYLNPNMKLLINPECYHKM--------CESC--------------DRIFTTGPAQCPTPGCNKILRKAKF................................................................................................................................................................................................................ 68
53 -10.400[C] COG1150 Heterodisulfide reductase, subunit C  ali follow..  22  40........................................................................................................................................................................................................ACYQCGTCTGS--------------CPSGRRTSYRTRLI--MRKLQLGLVDEVIKSDELW----MCTTCYTCYER--------------CPR..................................................................................................................................................................................................... 97
54 -10.200[R] KOG4602 Nanos and related proteins  ali follow..  15  233............................................................................................................................................................................................................CNFCKHNGESRHVYSPDGVVVC-----PILRHYVCPVCG-----------ATGDQAHTLKYC............................................................................................................................................................................................................................... 284
55 -10.200[S] KOG4020 Protein DRE2, required for cell viability  ali follow..  25  300...........................................................................................................................................................................................................ACKNCTCGLAEELEKEKSREQ------MSSQPKSACGNC----------------------DAFRCASC--PYLGMPAFKPGEKV......................................................................................................................................................................................................... 357
56 -10.100[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  9  100............................................................................................................................................................................................................CSVCLGDYQPNDKLQ----PVCKHTFH-----MDC-------------------LWHTT-----CPLCRLALIPSRSRQSQDDP-------VPSLVSPDEEVSSQPESEPVNHRVVSTQPESEPVNHSGVSSQPESQPVVNHRGVSSQPESQPVNHINDGHEQQCDQDVEGFKEMEEDERNNIGTSSACCSCRTVHYCCVSRDNQIMYAYNNAGDHRNNESLAALCLEKTPPFHKWYFETRGKKTFGFLMKDDFVYFAIVDDVFKKSSVLDFLEKLRDELKEANK 351
57 -10.100[K] KOG2907 RNA polymerase I transcription factor TFIIS, subunit A12.2/RPA12  ali follow..  15  9..........................................................................................................................................................................................................F-CLDCGDLLENPN--VLGSNVECSQC-DGATIKEKCPQCGNEEMNYHTLQLRSAD--EGATVFYTCTSCGYK...................................................................................................................................................................................................................... 120
58 -10.100[S] KOG4617 Uncharacterized conserved protein  ali follow..  12  44...............................................................................................................CQKYVEKLAVVQSEMVACATNWSIPPV----------CTKCFQNYINFKQFEYETKN-LNNVYSLDNRTCSQVIYDNYLLSYSTDIWEKS--RCDSCITIKWNMQFQLTNGSKICNLCYWKIYTTPDVDFCVDVETT----MNDTIHLWDDV---WKCAEKQDRNRDLFGIMITFGTLL....................................................................................................................................................................................................... 257
59 -9.830[S] COG4357 Uncharacterized conserved protein  ali follow..  15  3......................................................................................................................................................................................ETAIYGKTVDDQSRCVHDKYYACFECHQELSSHPLEKYDLLIICGVCYYDYNSNLICPNCRSPFNPGCK--LHYHLYFQ----NPPPAMC......................................................................................................................................................................................................................... 116
60 -9.800[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  22  26..........................................................................................................................................................................................................LRCHICKDFLKVPVLTP------CGHTF--------CSLC--------------RTHLNNQPN---CPLCLFEFRESLL................................................................................................................................................................................................................ 74
61 -9.800[L] KOG0287 Postreplication repair protein RAD18  ali follow..  22  26..........................................................................................................................................................................................................LRCHICKDFLKVPVLTP------CGHTF--------CSLC--------------RTHLNNQPN---CPLCLFEFRESLL................................................................................................................................................................................................................ 74
62 -9.790[BK] KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2  ali follow..  9  3...............................................................................................................................................................................................SSKGGRGAPKTAPTTVC----------------YCDGKRELGSVEVVCSTCLK---------------WHG--RCFTCKQCRP---TAEDWKAKKADL----------VQMCVTVLATLSAERLKADGKLSAEHVPEDFTYLSLKDEIVP-------------------NENWYMLTAIKQKKEWHQNLAPTLLKEKNIFVQHNDDDDLFALAEKNLSLLGPLHEAVKLIGKRPIERENREPRHIELPPIEGPKTRGASKRRHAEAPVTGKKQKLAADYSSTAAPNGVQIDIP..... 257
63 -9.780[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  8  285.......................................................................................................................................................................................................PDDLKCPLTGGLLRQPVKTS----KCCNIDF--------SKEAENALVESD----------------FVCPNCETRLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK................................................................................................................ 441
64 -9.770[S] KOG4623 Uncharacterized conserved protein  ali follow..  8  38...............................................................................................................................................DARVNCWFCNG--------------------------------NVRVPYQDRNSWT-----CPSCEQ-----NGFTKDGDY--TSQRDCSLGSQKCDQCAQRLKVESQFEPKNESRFDQELKVYLCSSCNKVLHEKKKMVLSSKF......................................................................................................................................................................................................... 190
65 -9.740[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  17  281.......................................................................................................................................................................................................EASRKCILCLMNMSD-PSCAPCGHLFCWSCLMSWCERPECPLCRQHCQPQE............................................................................................................................................................................................................................................... 331
66 -9.730[R] COG5141 PHD zinc finger-containing protein  ali follow..  9  133.......................................................................................................LDELDTMWLTYYNEFQLSEWENVSKEFLEIVLTIIEREWLELDGRCVICNEA--------------------------------------ECENSNAIVF-CDNCNTSVHQNCYFVPEGQWFCKKCLLAPHEVICCAFCPD---RDGAFCTTLDGRWHTI-VCCICKQCSDKNCYAAY-----HITCARRAGFFYKIYSHSASYDSVDMETY------CDKHTPPDYLNGLMKRLFPLAELYYKRMATDVPLNFQATKAPDFVPEGPWKSHPLPAFIVDKVTKVLLSYNVKRQDLPSIVTDICKFYHMK-------RRSRKDAPLLKSQLLMDSLENLPVRASKDRVRSLEVAKALQDQYQSLLTLVESTAKRQLLKCQLSN.... 515
67 -9.670[S] KOG4367 Predicted Zn-finger protein  ali follow..  7  5..........................................................................................................EEELKCPVCGS-------FYREPIILPCS-------HNLCQACAR-VQTPESESPQSHRAAGSGVSDYDYLDLDKMSLYSEAD-YGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPVPRNITCPQCHRSLILDDRGLRGFPKNRQSKAAALKCQLCEKAPKEATVMCEQ----CDVFYCDPCRLRCHPPRGPLAKHRLVP-------AQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRA----------KEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLME 368
68 -9.600[KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  14  325............................................................................................................................................................................................................CPSCSLVLILSTHLARS-KNWSEIPWSANPKSTHCFACQLPFPKPPVSPFDESTS----SMRYACPSC-------------KNHFCLDC---------------DVFAHEQLHECYGCQCSGN.................................................................................................................................................................. 421
69 -9.600[KL] KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  14  325............................................................................................................................................................................................................CPSCSLVLILSTHLARS-KNWSEIPWSANPKSTHCFACQLPFPKPPVSPFDESTS----SMRYACPSC-------------KNHFCLDC---------------DVFAHEQLHECYGCQCSGN.................................................................................................................................................................. 421
70 -9.480[K] KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors  ali follow..  19  51.................................................................................................................................................................................CAICGD--------RATGK--HYGASSCDGCK------GFFRRSNHMYCRQCVVDKDKRNQCRYCR--------------------KKCFRAGMKKEAV..................................................................................................................................................................................................................... 121
71 -9.480[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  10  1.......................................................................................................................................................................................................MDWIQCNHCGIKPNQTKLYLTA----CGHVF--------CQNCTKAAFNS------------------QCYLCKKPL---KVDEINKNLRPDLMELFKDPRQLASDLVNELKQVVAFQAKQREIYVKCKNAEAKKDTERFAEARSKHVEKTQEIEKRKKAFLEDNVKLKNAKEEKNQLMARLKELREQPSQNLSVNKRRSNTRTEPPFSKISRTGPPSVMRKASHEFSLNLRDQSTSKILTSTPLSNIDYSRRDHRNRLFGAGLEHPSPILRQ................. 240
72 -9.480[K] KOG4216 Steroid hormone nuclear receptor  ali follow..  11  98............................................................................................................................................................................................................CKICGDKSSGIHY----GVITCEGCFRRSQQSYSCKNCL---------IDRTSRN--------RCQHCRLQ--------------C--------AVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAI 350
73 -9.470[O] KOG2813 Predicted molecular chaperone, contains DnaJ domain  ali follow..  19  211...........................................................................................................................................................................................................VCPTCN-----------DGEPGFYKE-----QMMKCSTCY-----GRGLVAHKDGSDTICTNC-PCPTCQS----------RGLIKCQT--CDSTGS............................................................................................................................................................................................. 281
74 -9.470[K] KOG3815 Transcription factor Doublesex  ali follow..  9  29............................................................................................................................................................................................................CARCRN---GVLSWLKGHKRYC--------------------------------RFK---DC-TCEKCRQRVMAAQVALRRQQ--------ANESLESLIPDSLRALPGPPPPGDAVAAPQPPPASQPSQPQPPRPAAELAAAAALRWTAEPQPGALQAQLAKPDLTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELILK 272
75 -9.460[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  15  161...............................................................................................................................................................................................NAKLLEFQIRKFQCNVCFDEFNGTDCFQLTGHVSCQSCLRDYYTQIKCLDCGKELEEKRRYENDSNIIFCPRSFC-ICQKC-------------DFAFCSFC.................................................................................................................................................................................................... 297
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Godzik A. Fold recognition methods. Methods Biochem Anal. 2003;44:525-46. Review.