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Query: [V] KOG1716 Dual specificity phosphatase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRKRERENPCSICGHYHKYEEGEVCGVCGHCMPVSSDTVAPQQVHVSAFPSEILPEFLYLGSYDNASRSELLKTQGISRVLNTVPMCQNLYRNSFTYHGLDNEKVLQFDDAIKFLDQCEKDKARVLVHCMSGKSRSPAVVVAYLMKRKGWRLAESHQWVKQRRPSTDISPGKYLDFGLETYLLFLKLLLIAFSLYTEFYQQLQEFEQGIFGSEMMSAMNINDAPTFGFGFPKIDNQAQAPVFNNAPTSSIFSSPASSIPPQEFTFGATPPKPTTGGDIAMDGSLast
1 -104.000[V] KOG1716 Dual specificity phosphatase  ali  100  1MRKRERENPCSICGHYHKYEEGEVCGVCGHCMPVSSDTVAPQQVHVSAFPSEILPEFLYLGSYDNASRSELLKTQGISRVLNTVPMCQNLYRNSFTYHGLDNEKVLQFDDAIKFLDQCEKDKARVLVHCMSGKSRSPAVVVAYLMKRKGWRLAESHQWVKQRRPSTDISPGKYLDFGLETYLLFLKLLLIAFSLYTEFYQQLQEFEQGIFGSEMMSAMNINDAPTFGFGFPKIDNQAQAPVFNNAPTSSIFSSPASSIPPQEFTFGATPPKPTTGGDIAMDGS 283
2 -72.000[V] KOG1717 Dual specificity phosphatase  ali follow..  24  123..KDEGCRAFYLEGGFSKFQAEFSLHCETNPNSATDSDGSPLSNSQPSFPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFEGEFKYKQIPISDSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSN--ISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST................................................................ 381
3 -38.400[R] COG5350 Predicted protein tyrosine phosphatase  ali follow..  16  1.....................................................MT-CIVVSPLSRIA--EMAVKHKAREMVTLIAKEQSFVVAAERHLTLAMNDIAHVLKLIDFAGE-WDQSAPLLIHCWMGISRSPAAAIAALSLYPDQDETELAQRLRTVSPYV--TPNSRIIAIGDRLLGR................................................................................................... 143
4 -23.900[V] KOG1720 Protein tyrosine phosphatase CDC14  ali follow..  12  181....................................................LTPDFIAFASPQEDH-LNFFANNNVQLVVRLNSHLKHFEDIGIQHLDLIFEDLSIVKNFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWLYLHQNFREWKYTTRISLKPSEAIGGLYPLISLEEYRLQKKKLKDDKRVAQNNIEGELRDLTMTPPSNGHGALSARNSSQPSTANNGSNSFKSSAVPQTSPGQPRKGQN 438
5 -22.500[T] COG2453 Predicted protein-tyrosine phosphatase  ali follow..  17  186....................................................ISPKFIAFASPIQAGWLDYFVANKVKLIVRLNGPLKTFENVGIRHKEMYFEDVPELSLVKEFIDLTEEEDGVIAVHCKAGLGRTGCLIGAYLIYKHCFTANEVIAYMRIMRPGMVVGPQQHWLHINQV....................................................................................................... 337
6 -21.700[A] KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit  ali follow..  13  104..............................KVPLNESYNNHVPPGSRYSFKQVIHNQIDLTNTTRYYSTTDLKKEGIKHIACKGRDAVPDNVSVNAFVNE----------VNQFVLNLKHSKKYILVHCTHGHNRTGFMIVHYLMRSGPMNVTQALKIFSDARPPGIYKPD--YIDALYSFYHEIKPESVICPSTPEWKRSTELDLNGEALPDDEDDDGGPA............................................................. 295
7 -19.200[V] KOG1572 Predicted protein tyrosine phosphatase  ali follow..  16  61....................................................MVDNGIFRSGFPDSANFSFLQTLGLRSIIYLCPEPYP--SNGIRLFQFGIEPDHKIRMALKVLLD--EKNHPVLIHCKRGKHRTG-CLVGCLRKLQKWCLTSIFDEYQRFAAAKARVSDQRFMEIF......................................................................................................... 198
8 -17.300[A] KOG2634 Initiator tRNA phosphoribosyl-transferase  ali follow..  11  367.........................................................LSSTNLAVGASQVACKETSIDCILNCDQNVPVSYLEEHLHLPMKGSKFRNLPPAVNFAKLKMSSGKKVLVCCQDGAFDGGKSFEEKSITKM--DMRRMLIFICKYAV--NARPSRGNLKQVFGFLSSHRENSDE............................................................................................ 505
9 -14.900[S] COG3453 Uncharacterized protein conserved in bacteria  ali follow..  15  6.....................................................INDEYSVSGQITVDDLDEIKALGFKSIVCHRPDFEA--ELGLEITHIPVGMGVTADAVKSMVDALDEFQRPMLGYCRSG-ARSTAVYQQTLHIR........................................................................................................................................ 111
10 -11.100[T] COG2365 Protein tyrosine/serine phosphatase  ali follow..  17  99...................................................HVKWGKLYRSSN-NQADAALLQKLHIKWICDLVQAQPTPEIQGVLNKHIPIQSVDGFKEIFSEILTDAKAGLPFVFHCTAGKDRTG-VLAALLLTLLDVPEKTIFDYAITNR........................................................................................................................ 249
11 -11.100[TR] KOG2283 Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases  ali follow..  14  65.......................................................DFTYVTSRIIVMSLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLPIRQAPSLHNLFAVCRNMYNPKNVCVVHCLDGRAASSILVGAMFIFCNLYS-GPAIRLLYAKRPGIGLSPSH--RRYLGYMCDLLADKP.............................................................................................. 223
12 -10.600[T] COG5599 Protein tyrosine phosphatase  ali follow..  12  465..................................................TDIVPDYIYIACQAPKPGTEMVWHNSGT-IVMLTNKCSQYWPDNFWVHTWFDKTHPDIESITGIIRCIDKNDGPMFVHCSAGVGRTGTIAVDQILQVPK-SKDFIFNCVNSLRSMVQNFEQFKFLYDVVD....................................................................................................... 696
13 -10.500[T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes  ali follow..  12  321..........................................................YIASQGCLEATQMAWQENSRVIVMTTRKCVPYWPEHYQYLSWPDHGVPSEPGGVSFLDQINQHAGPIIVHCSAGIGRTGTIVIDMLMENCDIDIQKTIQMVRAQRSMVQTEAQYKFIYVIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKSLESSAGTVAASPVRRGGQRGLPVPGPPVLSPDLHQLPVLAPLHPAADTRRMCMRTCTLRTRG 621
14 -9.180[T] KOG0789 Protein tyrosine phosphatase  ali follow..  11  519..................................................GHLLTRKIELTSGTWKHSDDDPPIRTITH---------------FQFLKWKEGEGLEGEMSMDAFHRTRNNLDPIIVHSSLGTGRACAFVFQMINTKKCGTARFFQVDFRTKRLALQNGKQLFWVQNMA........................................................................................................ 642
15 -9.040[G] KOG2178 Predicted sugar kinase  ali follow..  9  108.RKLQKLKNVCYDAGFPRSDNYPCQTLFANWDPIYSSNTKEDIDSYESEIA------FWRGGQVTQEGLKWLIENGFKTIVDLRAE-DTFYLGKITVVQIPIDVAPKAEQVELFASIVSDSSKRIYVHSKEGVWRTSAMVSRW-----------------------------QYMTRPITKEIPVSEESKRREVSETKLGSNAVVSGKGVPDEQTDKVSEINEVDSRSASSQSKESGRFEGDTSASEFNMVSDPLKSQVPPGNIFSRKEMSKFLKSKSIAPAG 369
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Igarashi Y, Eroshkin A, Gramatikova S, Gramatikoff K, Zhang Y, Smith JW,Osterman AL, Godzik A. CutDB: a proteolytic event database. Nucleic Acids Res. 2007 Jan;35(Database issue):D546-9. Epub 2006 Nov 16.