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Query: [R] KOG1819 FYVE finger-containing proteins, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MQSFRKIWNKPRPDDWMPLARFYYADSALNDIASELDSFDGRRDPDRCNALVTRLRVAQDRVLHIITEMLIHLYPREQDRACRDFRVKFPDEILHDTLPGQLWFGAECLSAGSNIIDHETESDLIRPLAKDVTKQLDFLRDLLKNQSLRDPSAYNPVIKENLLKFDKLFAEFEYQYVSAMVPVKSVKEHDSQLDVAVLFSEVLSLALVKDLITQDLIDYCDPSVMIAIPRLGIVWGLLVYSNGALNVDVPAENLSEMFRPFYSLLVKIRNLLRILTPTELTKLETVLCKGESAVPEDTSSTLTMSDFRTNATDEEKAKNNQRVWMCDMPSDSTSSLDSSVQDSSSETTSLASSALASPHSGSEENVSQIENEEGDDEAIGTNSNSSNEVTESPETIEEPDNVDMEESSESEVDTHIDETRNESDDEITDDVQASDVLQVETKKCKSSRLLEQKKFDKSVKTIIPMQTDPRSQIDPKNLRSRFRSSEDLVHRLFVCIAGVADQLQTNYSSEIRKVLKLILQPSEIIPVYEVVNAQVANSQTEGEETGVEAQETLPLPAFMGVRWVPDEDCEQCTACSMPFNFVRRRHHCRNCGRIFCHKCSCNTISIPEHGYDRKPVVSSPQSNLSLLTRQDQFSCNLLHQSHHIHHLFNRSLVPHTYPLast
1 -180.000[R] KOG1819 FYVE finger-containing proteins  ali  100  1MQSFRKIWNKPRPDDWMPLARFYYADSALNDIASELDSFDGRRDPDRCNALVTRLRVAQDRVLHIITEMLIHLYPREQDRACRDFRVKFPDEILHDTLPGQLWFGAECLSAGSNIIDHETESDLIRPLAKDVTKQLDFLRDLLKNQSLRDPSAYNPVIKENLLKFDKLFAEFEYQYVSAMVPVKSVKEHDSQLDVAVLFSEVLSLALVKDLITQDLIDYCDPSVMIAIPRLGIVWGLLVYSNGALNVDVPAENLSEMFRPFYSLLVKIRNLLRILTPTELTKLETVLCKGESAVPEDTSSTLTMSDFRTNATDEEKAKNNQRVWMCDMPSDSTSSLDSSVQDSSSETTSLASSALASPHSGSEENVSQIENEEGDDEAIGTNSNSSNEVTESPETIEEPDNVDMEESSESEVDTHIDETRNESDDEITDDVQASDVLQVETKKCKSSRLLEQKKFDKSVKTIIPMQTDPRSQIDPKNLRSRFRSSEDLVHRLFVCIAGVADQLQTNYSSEIRKVLKLILQPSEIIPVYEVVNAQVANSQTEGEETGVEAQETLPLPAFMGVRWVPDEDCEQCTACSMPFNFVRRRHHCRNCGRIFCHKCSCNTISIPEHGYDRKPVVSSPQSNLSLLTRQDQFSCNLLHQSHHIHHLFNRSLVPHTYP 658
2 -32.200[T] KOG4381 RUN domain-containing protein  ali follow..  11  323....................................................DTAEIERSNLVNICKLVVKELLEDSDHLPLQHFFIVI-EHVLGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASV-RDLPTLRIALMQKKLSD-------------------------YLQALIEHREDSLFDYYEPHALMMSDEIVNVIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMKEDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSGGSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDIKQINLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLEKKWSHDKSNLGEILKTT-----SQTLTTQVTASEERAARAEAESRIEREWRISLQEKELKLKEKIANEAQTTLEELGIQLSVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAVGSPGIWAPDSIATHCTACEREFNLTRRKHHCRSCGEIFCKACSEHTLPLLNGQPGKPVRVLLGSLGRSCCSSAKSGFKIQPSCISKIWFGPMPK....... 950
3 -22.500[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  21  3...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CESCGVEFTVFRRKRACFDCKRYYCANCIAS-------------RRCKRCSVFAQRPLSRTDLLKLKPKD................. 59
4 -22.200[R] KOG1842 FYVE finger-containing protein  ali follow..  21  162....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DPVKRKEFEREVVPWLDDAEAVCCPLCASRFGLTRRRHHCRLCGRVLCHSCSKFLSFDTAKTLTSSSNPLGDTHIIVEEPNTVENEQELLQPEENGRRSFFSLSQKSM.. 269
5 -18.200[R] KOG4299 PHD Zn-finger protein  ali follow..  10  2..................................................................................................................................................................................................................................................................................................................DAKPWNHTSEAFQASILEDLKIIQKAGAERNAKSSHGSINSRSASPNKATSRRNRAQNGNSNGRASVDNSDDGSKDDLDYSPSVKRKHVNGEGAEKGDHDTSNNGPSITKLRRKVRRTYDTKDGFVAWNTLDDDFRPIVPDQERSRKINPQKGNNNNLLKENKSLKTTAKDLSDISSSSMKKANNSSKPLFSGKLTFKANIPVPTSEVVTENNVTRNVTVYSNQKHLGNESENFNDMEGRAEDISSNELLPTPEEYPYRYNN-DYCSACHGPGNFL-----CETCPNSFHFTCID---PIEEKNLPDDAWYCNECKHHSLYNELDEQEELESNVKEEGT............. 333
6 -18.200[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  11  2...................................................................................................................................................................................................................................................................................................................SDSTIFRFNSSILDQSADSNVSSSSSNSSVSDSSVDSHSSIESNSGHNTSVESQSSAESDSSADSHSSLERPSPVERDLSVESDSSSATNTSESSVGEASNQLQSPQSNNPLNMANLSVSTEDAHSQIRSLTQDVIQMEAELDRMNRYCEEVVAQIDTFATRTSTPTTRRIRRRTSPVEVIDLSHLDRAPPVRSARNRDPDAFIDLCTPEGPRSRTVNLHSNDSLTILPRRSAENDPVVDLDVASPPKRVNRDIDESQKEELYKCPICMDSVS--KREPVSTKCGHVFCRECIETAI--------RATHKCPICNKKLTARQ............................. 313
7 -17.700[TU] KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains  ali follow..  17  13...............................................................................................................................................................................................................................................................................................................................................................................................................................DKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEE---CHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQS...... 246
8 -16.100[R] KOG4377 Zn-finger protein  ali follow..  11  1...............................................................................................................................................................................................................................................................................MPKAQHSPQAIFTSFKLERSEYSGPGARLPGGSSSTVATAEDRLSLADHDGSATDLTPSRYRKRGRVWAPTSSLEQPSKRIVNQPTHFGARSETESRSSRHESLAQPTLQPSEPLETNSSTNLSSTILDKVSVVRAAGTFYPENANSAAQGETPEVVSSRYNSRQESNDLEVDQPEDLSMRPSLPEATATPAVVGPALNMNLLQFKQLIDLYQRQVLLPSFLAAASQPLALPGSAAGPGVSGPLLDMRILLENAAQQKLMLLNAAASATASAVAATTINSGQRTAAKRNRKFRFNEDCGHCNDCHYSFC---VQHHCRKCDYVCNEQCCSYAQRHTHY--------CVTC---------DGGVLSRAQLAAHKHRTGFPKQEADTTP 493
9 -14.600[K] KOG3815 Transcription factor Doublesex  ali follow..  14  2.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NGYGSPYLYMGGPVSQPPRAPLQRTP---------KCARC--------RNHHCKDC----CEKCI-----L----IIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAVAA.. 106
10 -14.200[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  8  330.........KDSIDEIKIM-----AEGRLSE--------------------LQASQEYNLSLSRQCQDIENELKDDQYIYSSRLYSL------INDRIH----WNAELDRYKILTEAIQAERSFVMRRDKELNLRAESLEAANHKTTTVGSRIEVLEKKLQSCIIEKNGLELETE------AIQDSERQDIKSEFIAMASTLSK--------EMEMMEAQLKRWKDTAQDALYLREQAQSLRVSLSNKADEQKGLEDKCAKQMAEIKSLKALIEKLLKEKLQLQNLASICTRECNDDRGLAEIKDSQRKAQAQAEELKNVLDEHFLELRVKAAHETESACQERLATAKAEIAELRTQLDLSEREVLELKEGIKVKEQEAEASIAEMETIGQAYEDMQTQNQHLLQQVAERDDYNIKLVSESVKTKHAYNTHLSEKQVMEKQLHQVNASVENFKARIAHNEEQMKGCFSEAYKLIQEHLVISLETTKWEVADADKEFRWLKSAVS-SSEKEYEQISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRLQEEVKNKNILKCGVCFDRP----KEVVIVKCYHLFCQQCIQRSLEIRH-------RKCPGC..................................... 885
11 -14.200[T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3  ali follow..  16  468.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDND-----IHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFALTRRRHHCRACGYVVCWKCSDYKAQLEYDG-GKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNS....... 644
12 -14.200[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  6  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PPRRSYPFSGHGGTIARFIEFGEAFGHYGEEEDEEEEDEEEAYVDYGEVQEEDEEEEEEEDSERQTREYIDVLDSPVRVSQNESEGIENQNRRMSNGNKVTLRDCLVLSVWK----GPANTKSGILDSIVFPVDTCM----DIPASTSGFSSDYASRVAAVDDEAHKRILFLEAKLRSIEQKTA...... 192
13 -13.900[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  20  3................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHIKVLDRHWHCADCGSVYCKKCTACQQGIPPTQVVRKAQACIICNRQLAT............................... 126
14 -13.700[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  10  2.......................................................................................................................................................................................................................................................................................................SDSGEPKPSQQEEPLPQPAAQETQSQQVCTFFKKPTKSKNIRKRTIDADEEDGDSKSESSILQNLKKVAKPDSKLYFSSGPSKSSTTTSGAPERSVFHYDSSKEIQVQNDSGATATLETETDFNQDARAIRERVLKKADEALKGNKKKASDEKLYKGIHGYTDHKAGFRREQTISSEKAGGSHGPLRASAHIRVSARFDYQPDICKDYKETGYCGYGDSCKFLHDRGDYKPGWQIEKEWEEAEKVRKRNKAMGVEDEDDEADKDSDE---NALPFACFICREPFV---------KCKHYFCEHCALKHH--------TKNKKCFVC..................................... 314
15 -13.700[T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins  ali follow..  7  118....................................................................................................................................................................................................................................................................................DAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYD---DEYFGRCARCGENVTAMDQVFHCIICKKAYCEQCNVCSKPIMERILRATGKTCVMCHRSL................................. 509
16 -13.500[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  23  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MVHCAGCERPILVLDRAWHCCECGKLYCKKCAGCAQGISPSDLVRKARTCMVCNKQLST............................... 101
17 -13.500[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  9  2...............................................................................................................................................................................................................................................................................................................................EQKNLNINQASGSKINTELAVPIFQSRRRHRPRQGLKRKKGFKRDDDSGGSSESSNEDMRDNIPIVSGRKKTVRLNRLQRESEQFENSALKDINVEYQSNLSATGESVNTTTVSAINEDTREVILGRPSPKLANQSTLPTELFQSQNDYSRFLPKRKDFEKKSQVGPVLSSNASTVRMNTIIDYQPDVCKDYKLTGYCGYGDTCKFLHMREDYKAGWQLDREWDSVQEKYKKGAKLEEGMVKNEKKEDIPFVCLICKKDYR---------TCGHHFCEQCAITRY--------RKTPTCIQC..................................... 291
18 -13.200[S] KOG4623 Uncharacterized conserved protein  ali follow..  14  42..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NCWFCNGNVRV-RNSWTCPSCGDYLCDQCNEAQRELKVYRLEKQFRLCSSCERHVNKVLHEKK......................... 182
19 -12.600[R] COG5048 FOG: Zn-finger  ali follow..  9  1MDTSNSWFDASKVQ---SLNFDLQTNSYYSN-----ARGSDPSSYAIEGEYKTLATDDLGNILNLNYGETNEVIMNEINDLN------LP-----------------------LGPLSDEKSVKVSTFSELIGNDWQSMNFDLENNSREVTLNATSLLNENRLNQDSGMTVYQKT-----------MSDKPHDEKKISMADNLLSTINKSEINKGFDRNLGELLLQQQQELREQLRAQQEANKKLELELKQTQYKQ---------QQLQATLENSDGPQFLSPKRKISPASENVEDVYANSLSPMISPPMSNTSFTGSPSRRNNRQKYCLQRKNSSGTVGPLCFQELNEGFNDSLISPKKIRSNPNENLSSKTKFITPFTPKSRVSSATSNSANITPNNLRLDFKINVEDQESEYSEKGLGIELLGKPGPSPTKSVSLKSASVDIMPTIPGSVNNTPSVNKVSLSSSYIDQYTPRGKQLHFSSISENALGINAATPHLKPPSQQARHREGVFNDLDPNVLTKNTDNEGDDNEENEPESRFVISETPSPVLKSQSKYEGRSPQ-LPRGSIDKCLGCTKTFK---RSHHCDGCDKAFC-PCGKKFNREDALVVHRSRMICSGGKKYENVVIKRSPRKRGRPRKDGTSSVSSSPIKEN... 669
20 -12.600[D] KOG3056 Protein required for S-phase initiation or completion  ali follow..  7  201.................................................................................................................................................................................................................................................................................................GQTFTAVPARKSAKLITKERDRLSMLAGYDVSPFAHTANHTSKPKTAEPTKIPYAERGGPVSRLAGGVEASRKQRVQDLERLRLLKEENERFEKKKQAEGHVLGSDNKKESEAGTPAVSMPTTPVPDKFKNRGFSFDASLTPKLSGSENFSFEINVGSRQAQNAKLKAAALLKKKPLEKINPNSTRGSESGKRRAIDELNEKFSSSAKRQKIDEDDRELMRKSRIEKIMAATSSHTNLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMP-------KAVICQVCK--YTAFSASDRCKEQKRFFCKDCGNRTTTVFKL----PKQSCKNCIREKKILTGRETLSVRGDEETFMGCLAGSANLNLLVP 578
21 -12.500[K] COG5641 GATA Zn-finger-containing transcription factor  ali follow..  17  125.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DANVPVCKNCLTSTTPLWRRD-CNACG-LF----KPRPISLKTDVIKSRNRKSNTNHAHNLDNFRNQTLIAELKGDCNIESSGRKANRVTS.. 220
22 -12.400[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  7  6.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................NQEPSSDSESPGGLMTALSPMLEELESAQERIQERIRQLEVIVSRIREREITTTTTPALVSPNEHRDSTAGVIHERSRERLVENGENKTYLIAKALNMEKTSS----VPGGFFDCNIC---LEKAED---LTCCGHLFCWGC------YQLPLIYLNIKECPVCDGEVTDAEVIPIYGNGDDCDGTKPKLEDCGISLPPRP 193
23 -12.300[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  8  2...........................................................................................................................................................................................................................................................................................................................................................................................SQKNFFDEGKSYGVNDYAGFHFENGADSSLPQVSAQGVVRETDSSNFDASPVASGSGISDVGPFGADFHQLQQHVQTPYGGMTMPASSSSGATSVPPEQDPSLSVSFNRLPKSASTKTKNGRIRSSRREDDNRIPFYDLDVAEGAEDDLQEDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVT-LCSVCQRGHSPLSNR--CDGCNSPYHQLCDDATVQDVD--------FCMKC----QYRRAKQPLETGMTAQDLGLSESDKKMYLSSLP 276
24 -12.300[R] KOG1314 DHHC-type Zn-finger protein  ali follow..  31  78..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VGPGFVPTMYLQYCKVCQA------RSHHCRKCNRCVCNNCCGYQ....................................................... 139
25 -11.900[K] KOG2845 Activating signal cointegrator 1  ali follow..  9  82..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLQQCFKKDEILDGQKSGDHLKRGRKKGRNRQEVPAFTEPDTTAEVKTPFDLAKAQENSNSVKKKTKFVNLYTRERQDRLAVALPGRHPC-DCLG------QKHNCLICGRIVCEQ--------------EGSGPCLFCGTLVCTHEEQDILQRDSNKSQKLLKKLMSGVENSG.. 238
26 -11.800[R] KOG1313 DHHC-type Zn-finger proteins  ali follow..  32  119......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NNYTFCNYCSK------RTHHCRTCGMCVCGNCVGAG....................................................... 162
27 -11.700[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  9  62...................................................................................................................................................................................................................................................................................................................................................................................................................................................HAQEVVLYDHPLEMDLTARIKEASAQGKPPLDIHVLPRDKHWQKLLMALIAELKPEMSGPALAVIENLEKASTQELEDMASALFASDFSSVSSDKAPFIWAALSL------AQMANLIPGKARAEYGEQRQ----YCPVCGSMPVSSLRYLHCNLCERVKCSNCQSGKLHYWSLDDEQAAESCDDCGTYLKI............................... 264
28 -11.300[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  10  14..............................................................................................................................................................................................................................................................EQYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKRHRGPGLASGQLYSYPARRWRKKRRAHPPEDPRLSFPSIKPDTDQTLKKEGLISQDGSSLEALLRTDPLEKRGAPDPRVDDDSLGEFPVTNSRARKRILEPDDFLDDLDDEDYEEDTPKRRGKGKSKGKGVGSARKKLDASILEDRDKPYACDICGKRYKNRPGLSYHYAHSHLAEEEGEDKEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGRSGHPSCLQFTPVMMAAVKTYRW-------QCIECKC----------CNICGTLFCDDCDR---EPPEGSWS-----CHLCLDLLKEKASIYQNQNSS.................... 391
29 -11.200[R] KOG1312 DHHC-type Zn-finger proteins  ali follow..  27  132.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PAIKCSTCR----IVKRSKHCSICNRCVCNNCIGKG....................................................... 174
30 -11.000[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  21  3..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................WI------QCNHCQTKLYLT-------ACGHVFCQNCTKAAFN----------SQCYLC..................................... 43
31 -11.000[O] KOG3579 Predicted E3 ubiquitin ligase  ali follow..  10  221...........................................................................................................................................................................................................................................................................................................................EHEQREAAAKEKQPPPPAHRGPADSLSTAAGAAELSAEGAGKSRGSGEQDWVNRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAGRLLGFEANGANGSKAVARTARKRKPSPEPEGEVGPPKINGEAQPWLSTSTEGLKIPMTPTSSFVSPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDANQVHSTTRRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPAS---LPDSSLACCTLCHERLE------HFVQCPSVFCFPCSRQS--IKQQGASGEV--CEKC-----------------------------PLVGSNVP 536
32 -10.900[R] KOG1315 Predicted DHHC-type Zn-finger protein  ali follow..  12  73.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................WKSIFTLPQQPNQKFHLSYTDKERYENEERPEVQKQMLVDMAKKLPVYTRTGSGAVRFCDRCHL------RCHHCSVCAMCVCNNCIGFS....................................................... 169
33 -10.700[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  13  2.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGDKVS----YHYCESCKGFFCQNCQ----------IDKTQR-CPYC..................................... 95
34 -10.700[KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  19  358....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ANPKSTHCFACQLPFP--SMRYACPSCKNHFCLDCD----------AHEQLHECYGC..................................... 416
35 -10.700[KL] KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  19  358....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ANPKSTHCFACQLPFP--SMRYACPSCKNHFCLDCD----------AHEQLHECYGC..................................... 416
36 -10.700[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  8  272.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SDNSNECVVCLSD-TLILPCRHCTSCADTL-NNC-------P---------ICRLFPGPPADPGGAEEARSPVPRVLQPRPGPEPGA...... 350
37 -10.600[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  12  3...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KNTAPFVVDTAPTTPPDKLVAPSIEEVNSNPNELRALRGQGRYFGVSDDDKDAIKEAAPKCNNCSQR-------HHCSKCDEVQCTLCKSKKERCPSIVLPFHTIYCYNC..................................... 167
38 -10.600[O] KOG2813 Predicted molecular chaperone, contains DnaJ domain  ali follow..  10  1..........................................................................................................................................................................................................................................................................................................................................................................................MDKPLLSGSEKTNESERLDSYQYLQRNSSSARNPSFAGAGVVTVEEIRTASAVSSDPPSLYPPVIKTPVSLPIPQAIGYPSASGAGHELQQRQFLDEIEIRELL---IDHIGHRCCWGSRPARTWKIHAVEDCNVYVGTLDTFIEEREALTQTVPFTGGEFNGKKHGSEPGLWELDLRPQFPTLFVPYKETQVCPTCNAD----GSDTICTNCGKLPCPTCQSR-------------IKCQTC-----TGSLLTSSIAVVKWKTLSKRKVSATRGAGSVP 310
39 -10.600[O] KOG2164 Predicted E3 ubiquitin ligase  ali follow..  9  5............................................................................................................................................................................................................................................................................................................................................................................EKSALGEMPSNSNSSSKLNAKSPNFIPSSSNIPRSSAKTKEHSADRKPHRNSEKKTQGMPRKNQQLASSERKTKNKKRLEKQSSAIADSIGESLDDPQTVYDEHLFDILSARTNKRGQINLNHLLN-------QFTPRTNSNAFSAPPRRSRGYNTYGQGSGHHPMDKSRYVNANYRFVVSPIGDYQSQKLDPDSPVKWSSDFQLAACPFCLEEKPVAAR-----RCGHVYCFSCLLRFVETPTAAEVKAARSCPICWDSIRLR.............................. 279
40 -10.500[TZR] KOG1704 FOG: LIM domain  ali follow..  14  197.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SWHFH----QCAQCNDVFHSSSSTFSCTTCRLSFCCVCSKNLLGVKYSRVGESL-FCGYQTCGGEDEELLDEDRLGSPHRKVTQKSTKVVRIPAS.. 328
41 -10.500[R] KOG3002 Zn finger protein  ali follow..  10  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................APGGSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMY-----HQCPN-GHTLCSSCKL-----------RVQNTCPTC..................................... 92
42 -10.500[K] KOG2857 Predicted MYND Zn-finger protein/hormone receptor interactor  ali follow..  16  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MCPRATQTCEICEKVVS----KYKCPSCLVPYCSGCFKIH....................................................... 37
43 -10.300[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  9  3......WL--------------------LERMLRTLTTASNT-----------------GSLFSFVPEVYVNTLPILLDAVMDFSHHDLKAQFEASDAECSVNAAAEFLGIHSA--DPRIVLASCKDSLLQALGTLTCHKSGVRALERTSKRSQASLVRALLRPYERAWGQSNWLLLRFWMGEGYAYKDSRQPSVWQGGSLPLHQGLCRSRSRNETHTGLLHNVAPANPSKRLIGAKLLEDEPFATLNSVLSQLNWAFSEFILLLQEIQNTAQRQENTLFEPKQLKICSMCFELTVSLMRCLEMVITTAPEIVTDESRPNSDLLLNRICQLISQVLSRVTVPPGCFQFVVDMCSADLNAVTHYPIVTAALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFALGEIRTPLLEQKNIPRGNFDPSSRPHIDPLTNDVRVPLPNNSKRIRADPPILKFA-----------------------------LNDFPSHVSSEEIDNVRRLIDSLRVKQTLLSDITLP-----------------------------------SEDSLCPICTAVFT----------CKHQSCSDCIMQHM--------MNSKVCFYCKTTIQTIETLDGTVIFSNDDVVQTPMIERA....... 538
44 -10.200[K] KOG2461 Transcription factor BLIMP-1/PRDI-BF1, contains C2H2-type Zn-finger and SET domains  ali follow..  25  560.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GERPHRCDICDKRFSSTSKTHHCDVCDAKFCGTCGKKYISPSGLRTHWKTTTCKEE..................................... 647
45 -10.100[O] KOG0802 E3 ubiquitin ligase  ali follow..  13  346...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LPDATSEECAICREPMAKAKR-----HCNHLFHLGCLRS---LDQG--LNEVYSCPTCRKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNN.. 437
46 -10.100[R] KOG1311 DHHC-type Zn-finger proteins  ali follow..  17  55.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VSSNLLMAMLLDPAVHPYAIGSEEPTQVDDLRAPLYKNVDINGITVRMKW--------CVTCK----FYRRSSHCSVCNRCICHNCVGKR....................................................... 143
47 -10.100[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  12  2.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NASTSSPSQQLQQAINSTIDKECAVCYSEMI---------SCGHKFCFICLKGVS-------VSNNGDCPIC..................................... 63
48 -10.000[TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved in axon guidance  ali follow..  18  71........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSNCAGCGRDILALDKQWHCKSCGAPYCEACTGKVLEAGDKHYHPSCARCSRC..................................... 162
49 -10.000[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  7  3.................................................................................................................................................................................................................................................................................................................................................................................................GKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMDPSTAGGVPFGLYTPASRGTGDSERAPGGGGSASDSTYAHGNGYQETGGGHHRDGMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEMHFIMCLSKPRLSYNDDVL-----TKDAGECVICLEELLQIARLCH-KSC--I-CPEHPAD........................................................ 227
50 -9.940[O] KOG2824 Glutaredoxin-related protein  ali follow..  9  2.................................................................................................................................................................................................................................................................................................................................................AGLEKNADFSGKTTKSATTTSFFNRSLTIHGRTVVDSGPKSHNLNPSLNRTTSITKFYTPVESMGTSLKGKVKNLCRLFETSKPVKPALAEIPQKQKSGKSLLPESRISPFSSLNNSVIRLPGTEDRIVVYFTSLRGIRRTYEDCYAVRMIFRGFRVWIDERDVSMDIAYRKELQIAMGEKSVSLPQMGKYVGGADVIKSLFEIGELAKILKEFPMRQPGFVCHC-CGDIRFVPCSNCSGSKKLFDEDERCPECGLIRCPDCSS......................................................... 274
51 -9.920[R] COG5273 Uncharacterized protein containing DHHC-type Zn finger  ali follow..  15  121..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LASFIRTATSDPGVLPRNIHLSQLRNNYQIPQEYYNLITLPTHSSISKDI-------TIKYCPSCR----IWRRSSHCSTCNVCVCNNCIGKR....................................................... 213
52 -9.880[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  11  4......................................................................................................................................................................................................................................................................................EAHHLNPLFSSNREMIHPVEASGVVYNTQMRYGTVPTFNPTVECQTSLFNPIYNISPVDRLVHQSMKPTIQSVDSSLTFNSDNNVDFLRPVSSRKRSREESVVLNPSAYMQIQKNPTDPLMFLGQDLSSNVQQHHFDIDRLISNHVERMRMEIEEKRKTQGRRIVEAVEQGLMKTLRAKDDEINHIGKLNLFLEEKVKSLCVENQIWRDVAQSNEATVNALRSNLQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCR----------VGMSMCRSCEASVLLLPCRH-CSVCGSSLCPICKS---------KTASLHV......................................... 331
53 -9.740[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  14  253....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQL--CVVCTNPKEII--------CGHVLCEDCASVTCPVCRGSIVSKAAA......................................... 335
54 -9.710[S] COG4306 Uncharacterized protein conserved in bacteria  ali follow..  11  16..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ATTAADEAF--------CSHSGEATYPKCSAS---------YEPPTFCNNCGSRFPWAERKIAGTVELVEAGTDLTPDEVQQFRTDLT 111
55 -9.710[K] KOG4216 Steroid hormone nuclear receptor  ali follow..  10  1..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARSSSTCSSLSRLFWSQLEHINWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSS----IHYCEGCKGFFCKNCL----------IDRTSR-CQHC..................................... 153
56 -9.670[S] KOG4317 Predicted Zn-finger protein  ali follow..  15  3...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PEKTIISSESSNSSPLNPSSTRIICHVCNKQFS----QYTCPRCNFRYCSPCYKSH....................................................... 55
57 -9.550[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  13  1.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KECKKCKSNEYT-QLVMMINECGHPLCKNCVDN--------FALNSGNCHVCNRVLRKN.............................. 53
58 -9.530[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  9  307..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNI-------------------CIICMDELIHKPKR----PCGHILHLSCLKNWM--------ERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIA.. 434
59 -9.480[R] KOG3608 Zn finger proteins  ali follow..  20  201.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NKKQVACFHCGELFRTKTTDHQCAQCFKFFCTMCSSLTTHIRYRHLKDKPLKCSECDTRCVRESDLAKHVQIVHSKT................ 316
60 -9.430[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  12  5...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ITTDTLLRCHICKDFLK---------PCGHTFCSLCIRTHL--------NNQPNCPLC..................................... 65
61 -9.430[L] KOG0287 Postreplication repair protein RAD18  ali follow..  12  5...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ITTDTLLRCHICKDFLK---------PCGHTFCSLCIRTHL--------NNQPNCPLC..................................... 65
62 -9.410[KD] COG5189 Putative transcriptional repressor regulating G2/M transition  ali follow..  9  94.........................................................................TPQDIAKLRR-------ESIAHSQGMGGVSWGS--ISVGSWLRDE-AYTAYLPNLEKQYCKSLPGLHDLLRH--------------------------YEEAHISTSPNTTNMSQIPMNSAGNTSSSVRMTNNTSSANYNLQNNMAANTK------------NAGHKTNTMQAHSSNATNNTSINNMHANLQSNMDSNSTIRQSQHPHHQQNIIQQQLQSNSVNHTSGAVPTPSVMGSATASSTTANPNVISITGAPNSGLSMANHSQQLHLNGNLVDAVSTNDVFLRTSNSPSRHVPHNKQINSNNNSGININNNTSHNSNINMGSKNAMVNRPHTFNNYSLNKTSRNPIQHQSRKIDPHQTDLSPLVLVQDIDLSFMDDDILGPSNHNSMNSVVNPTTGSHNYNTFHSSVHAKSSQNMVEDQDIDDIDDDDDVDDDDDDDDDDDTENGSSSNGKSVHNNNYKMPQQAYIDDPARRLYVMDHEEQKP---------KC-GCEKTYK---KYHHCEVCGKRY-----KNLNGLKY.................................................. 676
63 -9.410[R] KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger  ali follow..  24  126..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ECDGCGLA-PLIGFRYKCVQCSNYLCQKCELAH....................................................... 158
64 -9.390[O] KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase  ali follow..  19  72....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QRNRDKFCFACR-------QQGHCFRCGSK-CFICHSGQCEQNPKGLYPKGGCCKFC..................................... 156
65 -9.380[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  16  233......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMS------SCAPCGHLFCWSCLMSWC--------KERPECPLCRQHCQPQE............................. 331
66 -9.380[V] COG3183 Predicted restriction endonuclease  ali follow..  11  152................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KVDYQTFPSEKDELTSSIVESTPEGKKILCYTTRYERNAQNRRCQGCGFDFEKTYGEHHVK---------------PLCEEEETDLICVCANCHRMIHRRKDSVLSLKELQELLLANKS........... 279
67 -9.340[S] KOG4020 Protein DRE2, required for cell viability  ali follow..  22  299.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KACKNCTREQMSSQPKSACGNCGDAFCASC----LGMPAFKPGEKVLL......................................... 359
68 -9.140[R] COG3582 Predicted nucleic acid binding protein containing the AN1-type Zn-finger  ali follow..  28  16.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KHCAYCRQDFLPFH----CSFCNEDFCHHCRW......................................................... 52
69 -9.040[C] COG1145 Ferredoxin  ali follow..  25  284...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VDTSRCIACGICRCPMKAIK-AEKCLGCG--VCPTCPMEAIEL.................................................... 337
70 -9.010[O] COG0068 Hydrogenase maturation factor  ali follow..  14  49...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EGALTEFVARLQQECPPLAKINELIRTPYQGELNFHDFVISHSVSGVVRTEITPD--AATCPECQREFDPFSRFYNCTHCGPRLCPECEDSYHDVENRRFHAQPVACHTCGPKAWLERADGKPVTASMFSMLDDVDAVCTLLQK... 216
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.