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Query: [R] KOG1881 Anion exchanger adaptor protein Kanadaptin, contains FHA domain, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLAPLRNAPGREGATSPSPPTDATGSLGEWDVDRNVKTEGWVSKERISKLHRLRMADILSQSETLASQDLSGDFKKPALPVSPAARSKAPASSSSNPEEVQKEGPTALQDSNSGEPDIPPPQPDCGDFRSLQEEQSRPTTAVSSPGGPARAPPYQEPPWGGPATAPYSLETLKGGTILGTRSLKGTSYCLFGRLSGCDVCLEHPSVSRYHAVLQHRASGPDGECDSNGPGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVVRFGGSTRLFILQGPEEDREAESELTVTQLKELRKQQQILLEKKMLREDSDEEEEMDTSERKINAGSQDDEMGCTWGMGEDAVEDDAEENPIVLEFQQEREAFYIKDPKKVLQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMIQCSLEACRILDTLGLLRQEAVSRKRKAKNWEDEDFYDSDDDTFLDRTGLIEKKRLNRMKKAGKIDEKPETFESLVAKLNDAERELSEISERLKASSQVLSESPSQDSLDAFMSEMKSGSTLDGVSRKKLHLRTFELRKEQQRLKGLIKIVKPAEIPELKKTETQTTGAENKAKKLTLPLFGAMKGGSKFKLKTGTVGKLPPKRPELPPTLMRMKDEPEVEEEEEEEEEEEKEKEEHEKKKLEDGSLSRPQPEIEPEAAVQEMRPPTDLTHFKETQTHENMSQLSEEEQNKDYQDCSKTTSLCAGPSASKNEYEKSRGELKKKKTPGPGKLPPTLSSKYPEDDPDYCVWVPPEGQSGDGRTHLNDKYGYLast
1 -210.000[R] KOG1881 Anion exchanger adaptor protein Kanadaptin, contains FHA domain  ali  100  1MLAPLRNAPGREGATSPSPPTDATGSLGEWDVDRNVKTEGWVSKERISKLHRLRMADILSQSETLASQDLSGDFKKPALPVSPAARSKAPASSSSNPEEVQKEGPTALQDSNSGEPDIPPPQPDCGDFRSLQEEQSRPTTAVSSPGGPARAPPYQEPPWGGPATAPYSLETLKGGTILGTRSLKGTSYCLFGRLSGCDVCLEHPSVSRYHAVLQHRASGPDGECDSNGPGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVVRFGGSTRLFILQGPEEDREAESELTVTQLKELRKQQQILLEKKMLREDSDEEEEMDTSERKINAGSQDDEMGCTWGMGEDAVEDDAEENPIVLEFQQEREAFYIKDPKKVLQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMIQCSLEACRILDTLGLLRQEAVSRKRKAKNWEDEDFYDSDDDTFLDRTGLIEKKRLNRMKKAGKIDEKPETFESLVAKLNDAERELSEISERLKASSQVLSESPSQDSLDAFMSEMKSGSTLDGVSRKKLHLRTFELRKEQQRLKGLIKIVKPAEIPELKKTETQTTGAENKAKKLTLPLFGAMKGGSKFKLKTGTVGKLPPKRPELPPTLMRMKDEPEVEEEEEEEEEEEKEKEEHEKKKLEDGSLSRPQPEIEPEAAVQEMRPPTDLTHFKETQTHENMSQLSEEEQNKDYQDCSKTTSLCAGPSASKNEYEKSRGELKKKKTPGPGKLPPTLSSKYPEDDPDYCVWVPPEGQSGDGRTHLNDKYGY 796
2 -62.800[T] KOG1882 Transcriptional regulator SNIP1, contains FHA domain  ali follow..  16  104..TVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSGQGQGRDRDTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQELVPRPGGNNKEKEVPAKEKPSFELSGALLEDTNTFR---------GVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIHRQSAYLLGRHRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTRRVKPYIIDLGSGNGTFLNNKRIEPQRYYELKEKDVLKFGFSIREYVLLHESSDTSEIDRKDDEDEEEEEEVSDS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 396
3 -26.000[T] COG1716 FOG: FHA domain  ali follow..  12  17...............................................................................................................................................................DLTQPSRFLLKVLAGANIGAEFHLDSGKTYIVGSDPQADIVLSDMSISRQHAKIIIGNDNS----------VLIEDLGSKNGVIVEGRKIEHQ--STLSANQVVALGTTLFLLVDYAAPSDTVMATISSEDYGLFGRPQSPEEIAARAAEEEEEKRKRATLPTGAFILTLFIGGLALLFGIGTASLFHTKEVVSIDQIDLIHDIEHVIQQFPTVRFTFNKNNGQ-----------------IGHVRNSIDKSELLYKVDALSFVKSVDDNVIDDEAVWQEMNILLSKNPEFKGISMQSPEPGIFVISGYLKTEEQAACLADYLNLHFNYLSLLDNKVIIESQVMKALAGHLVQFANVHVSFTNGEAVLTGYINNKDADKF---------------RTVVQELQDIAGIRAVKNFVVLLPAEEGVIDLN................................................................................................................................................................................................................. 406
4 -24.000[T] KOG3872 FOG: FHA domain  ali follow..  10  1.MVELEKRRRPPPQLQHSPYVRDQSNSQGMTKTPETSPPKRPMGRARSNSRSSGSRSNVDIDQYTIPPGLDLLPTASSPPSVHQVSQQQQLSPILANKIRSPFENQSQDQNDNSIDPTPAGQVTIPVEAVSPPALDELSKFQNGSTET------LFRTGSPRKKHTHIIILKSLNATFETKFLFKPDGLKLGRPVT-NGNFDSRVLSRNHACLSC---------DPTSGKIYIRDLKSSNGTFVNGVKIRQNDV-ELKVGDTVDLGSDPTNLVMKKQDHTNKNNGNSTNINGIKIDRGHHNQHIPIRSHLKENYTEAGVTSATTAQRAAFEAAMFGDINNSELDDDILGPETEVLSGIFINNSAGTSINLINMIKTLTTELSLEKQELEKLHSMQNFMQNYTINLDFINKHMIDMNEKHLLKLSTAL------------------QKTLSENNDALLKESEDQLKEIKQQNNKVKSACSLKEKQNHEKLQELESELRELNLQIEEERGKNLVLTQSNFNGGINNDNNAKVKQNDSREEKKD--TEDTLISTEELGVVEGKRTRVSKGMLFGVVAISF........................................................................................................................................................................................................................... 592
5 -17.500[KT] KOG2293 Daxx-interacting protein MSP58/p78, contains FHA domain  ali follow..  11  499....................................GNHPEKDSENCKEKNVVPPVNESPHAKDTDDGLIEITVPELEITRAEAEAEAEAHVCESDEDLPNYSDIEAMILDMDLEPDDQDNFDLEVSKYQSQDMKRTIIRLEQAAHSYMQRAIASRGAFAVLYGRYSKHYI-------------KKPEVLVGRSTDIDLGREKRGISRRQAIIRLGDDGS----------FHIKNLGK-YSISVNEKEVDPGQSLILKSDCLVEIRGMPFIFET.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 719
6 -14.100[T] COG3456 Uncharacterized conserved protein, contains FHA domain  ali follow..  11  35..............................................................................................................................................................................................VGHAPECHWSVQDRQIPAQAFTVILH-----------DGTFCLRP--QTAQLWLNQAKTATSDLIQLRQGDEIQIGR----LMVRVHLNRGDIPHYDEEMATPETIVTNRDMLTDTLLSTEGAPHYPGMTHRHQLADTVVNGFSADPLQALQSESLITTGDPLSGIAAVRPSAPLSDPASNGGINT---------------------------PFMDLPPIYASPGDHNDDISAAEMAQRHLAVTPLLRGLGG---------------SLTVSNSDDADDFLEEAGRT--------------QAAIKGLLDLQQQRNSLSDKHLRPLED----NPLRLNMDYATALDVMFAEGKSPVHLAAPA--AVSESLRNVRHHEESLRVLLDAFSPQNLLRR.................................................................................................................................................................................................................. 363
7 -10.600[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  10  523........................................................................................................................................................................TGQIAENLGEEEQLVQGLCALLLGKEKLKQLIEKRIGKENFIEKLLYSRASQKPQPNFPSPEYMIFD-------------------------EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVT---QQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSAR-----------DSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKASEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQD-QKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDH............................................................................................................................................................................ 961
8 -10.500[D] KOG0615 Serine/threonine protein kinase Chk2 and related proteins  ali follow..  9  3....................................................................................................................RETKRRRSSAEKPIVVPVTRDDTMPVDEDLVVEESQCAALKPFA-------KLVGVRRG--ISSIDLADDH-FVCGRGSPTNFNFSYKFISKIQFSID----------DTETRRIYLHDH-SRNGTLVNHEMIGKGLSRELMNGDLISIAIALIIFVYERADDNHHPEELTNKYHVTSHLLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSR---------------------------AIAKTRDIQNEVEVMKKL--SHPNIVAIYDCITVAKYSYMVIEYVGGGEFFSKLVDSKYNQMGLGESLGK-LIDAVLYLHSVGICH----------RDIKPENILCSNKAE----------------------RCILKLTDGMAKNSVNRMKTHCGTPSYCAPEIVANQGVEYTPKVDIWSLGC-----SEEYTDLKMDEQVLTITDETQNMIQWMLTVEPLIRPSAVELMSTQWMKCADCLSAKQDILKSIQPISAAPAALQTTQAGP........................................................................................................................................................................ 468
9 -9.450[R] KOG2295 C2H2 Zn-finger protein  ali follow..  10  179................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEYKTDFKRQQLNEFFVAHKDEFKNK----EDSVKRSEEQRGFLQRRTDVFMELLENIGSVKVDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQP-LAPSITRSEIEAVCNRFSGY 541
10 -9.060[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  5  523..ERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGRSVRPRKSPEPVVAEAAEAPSSKRYYEDRERYRSSDRERRDRDRDRDRERERDRDRHFTNDGRGLPLDPSNFTSQNPGNIKTGRPKSAAVAGGSMEKPRGQSAWDIIDTDAQQTTSIPQQNFNIIVL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 702
11 -9.060[G] KOG3893 Mannosyltransferase  ali follow..  6  41.....................................................................................................................................................YISFYFII-ISSVPLEEYLNLLGHSSIIYVMLKRRFYEQSVYNAKNGMLVYVVHKSILQIGVTLTFIISQKAALVSIGISTLYYVQMEVKSALIS----YDRSLFKFYPIDLFVLL---QSFICIIAINFQKEERNFRGKSNSAFYNDFIQSFKSEDLIQEYESSLLLEPSLRLRISYLALFLKNTLQFGYIRKKENVNLNLVKTPKYDDLTKMNLSSSTANTLIKGIQSYNFQNYEKAYSLLAAGVTNSLLEWTNTSVSDKEYLR---IQCFIQSCLQYRLTQDEKYLIDLDVKVCSLFNTSAREALIHYAKAMKLLSKYNSRENMITKLRESSLYLLYAPTDAFLLLLLGLLMRLIWHDRRSALKFTDIDYFVFSDASKYVSIGMSPYLAILLLPTQYGFPSWGKYLFSISDLSYKRSLIYSSFWILNPFVAIISTRGNCEA........................................................................................................................................................................................................... 564
12 -9.040[R] KOG2030 Predicted RNA-binding protein  ali follow..  8  457..............................................................................................................DMKRSAAQKEKKTVDASQKALKSAERKTQQTLKEVRTISNIVKARKVFW-----EKFYWFISSENYLV-----------IGGRDAQ-DIYVHAEIQGASSVIIQNPTGEEIPPKTLLEAGSMAISYSVAWDAWVTSDQVSKTA----PTGEYLATGS----FMIRGKKNFLPSCHLTMGLSLLFKLEDSFIERHLGERKVRSLEDDQIDPNVKENEVEHDLLSDNEDADSNINLSEPSSNTEITAFPNTEVKIEHDTGRIIVRSDS--IEETKESEVVLDKILKKTDDEETTIILAGPSRKKQVSAKKTKEDKARAKQEAAKQEVPPVSSEPKNPSQVKRGQKGKLKKMKQKYKDQDDEEREIRMMILKSSGKEKPQASADKVVEKSESTKEYVKPEKSAAPKNPVELDDADEVPVGGDVDVLNSLDELLFAIPVVAPYQALQNYKFKVKLTPGTGKRGKAAKLLKSIKEESL..................................................................................................................................................................................................................... 952
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Flexible structure alignment by chaining aligned fragment pairs allowing twists. Bioinformatics. 2003 Oct;19 Suppl 2:II246-II255.