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Query: [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSQNKIERISKEVAERLTTAQVVVSLSSAIRQLIDNSIDAGSTIIDIRVKNNGFESIEVQDNGSGIEARNFDALCKPHSTSKLTQFSDFDKLATLGFRGEALNALCTVSSVSIFTRASDTEIGTRLTYDHSGNIICRQSAARELGTTIIVNKLFETLPVRRKELERSQKREFVKLLSTVQSFALLCPHIKILCTNNINGKKTNLICTPGGTTSIQDVVANLFGIARKIENSKIGSGLIPIQQNQPDVEIMTIHSVPMEEMHFFDLFKIRGFVSSCEHGCGRGTSDRQFVYINNRPVEYSRVCSVINDVYKQFNKKQYPIIVLFIDVPPEKIDVNVTPDKKTVMLEKERHLLAVVRASMMKTYLKIVGSHSTVRSSVEDRRIMNLSQQSFSNASFMSSKSSTPDDFNNTTLNSTYPEDSLLNTSDLLKQRKENRSPPAKKSCPMIRRTEPFHSVPSTSNSRTQRLENFSFTMEPKRVEVSKKIPSKSDKKLTDEELRSAVIEENPLKKAGEIDDIEILEQSQESQDVNESQCSQDSQTSQNSRVSYFTLRPQQKIKFSMKLLREAYSPKTDETDDNTEEAEVSAEKDVLNEITTKINKEENDDAERQLSRSLTKDDFSKMKIIGQFNHGFIICRLRGHLFIVDQHASDEKYNFERLQSSAKLTKQPLFMPTALGFGAVQELIIRENLPIFHANGFDFEFSENDGCIKTFLTARPELLNQQLTNSDLEEILAVVSQYPNQMYRPVRIRKIFASKACRKSVMIGKPLNQREMTQIIRHLAKLDQPWNCPHGRPTIRHLASLPDRAEFELast
1 -160.000[L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family  ali  100  1MSQNKIERISKEVAERLTTAQVVVSLSSAIRQLIDNSIDAGSTIIDIRVKNNGFESIEVQDNGSGIEARNFDALCKPHSTSKLTQFSDFDKLATLGFRGEALNALCTVSSVSIFTRASDTEIGTRLTYDHSGNIICRQSAARELGTTIIVNKLFETLPVRRKELERSQKREFVKLLSTVQSFALLCPHIKILCTNNINGKKTNLICTPGGTTSIQDVVANLFGIARKIENSKIGSGLIPIQQNQPDVEIMTIHSVPMEEMHFFDLFKIRGFVSSCEHGCGRGTSDRQFVYINNRPVEYSRVCSVINDVYKQFNKKQYPIIVLFIDVPPEKIDVNVTPDKKTVMLEKERHLLAVVRASMMKTYLKIVGSHSTVRSSVEDRRIMNLSQQSFSNASFMSSKSSTPDDFNNTTLNSTYPEDSLLNTSDLLKQRKENRSPPAKKSCPMIRRTEPFHSVPSTSNSRTQRLENFSFTMEPKRVEVSKKIPSKSDKKLTDEELRSAVIEENPLKKAGEIDDIEILEQSQESQDVNESQCSQDSQTSQNSRVSYFTLRPQQKIKFSMKLLREAYSPKTDETDDNTEEAEVSAEKDVLNEITTKINKEENDDAERQLSRSLTKDDFSKMKIIGQFNHGFIICRLRGHLFIVDQHASDEKYNFERLQSSAKLTKQPLFMPTALGFGAVQELIIRENLPIFHANGFDFEFSENDGCIKTFLTARPELLNQQLTNSDLEEILAVVSQYPNQMYRPVRIRKIFASKACRKSVMIGKPLNQREMTQIIRHLAKLDQPWNCPHGRPTIRHLASLPDRAEFE 805
2 -115.000[L] COG0323 DNA mismatch repair enzyme (predicted ATPase)  ali follow..  21  1..MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVAR-GGEVEEVIPATSPVGTKVCVEDLFFNTPARLKYM-KSQQAELSHIIDIVNRLGLAHPEISFSLISDGK-----EMTRTAGTGQLRQAIAGIYG-------LVSAKKMIEIENSDLD-------------------FEISGFVSLPE--LTRANRNYISLFINGRYIKNFLLNRAILDGFGSLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSEAIANSLKEQTLIPDALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLDRLTKPAKLHFAE--------------------------------------------------------------------------------------------------------------------------------------RKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERVKYEEYRENVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLA---EYGENQFILREHPIWMAEEEIESGIYEMCDMLLLTKEVSIK-KYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFR 634
3 -100.000[L] KOG1979 DNA mismatch repair protein - MLH1 family  ali follow..  17  5.SRAKIRPLDQLVINKIAAGEIIERPENAIKELIENSLDAGSTSIDVLLKDGGLKLLQITDNGSGIQYDDLPYLCQRFSTSKIDNFNDLQHLQTFGFRGEALASISHVAKVTVVTKLSSDIHAWKAFYVDGGMSPAPQPCAGKQGTVITAEDLFYNVRSRKSAL-KNGSEEFRRIMILVQKYAIHNDQVSFNCKKVGDTVAS---LSLSSRLSKADKIRHIYG-------PRVASHLRDFSLGEGQ-------------------SSIVGFSANGFISNAQDKKSNLILFINNRLVESVELRHALEETYAKLHKGASYFVYLSLNMSPEQLDVNVHPSKRIVHFLYDQEIATSICDKLGEILERTDTERSYPLQAMIPSISNTKNAESSSQKAVRTYENYLVRTDPRERSIKSMLSDNFLQRSSNNYDNEIIEKVDSANSNKNATNDIKDLQTEEIVEEGNSI---------------------------------------------------------------------------------------------------------------------------------DLESIKSLQKQVINSMHVLATNILTEHKYVGLVCPTRRIAQHNIGLYVVDYGKLSYHLFYQICLTEFNYGEFVLETPLSISFEIVNGDEDKSESEKFTRLLVSRRLKDYFSTSGGLLTAVPMLSPKYHPPLLISSLTPKFFDWLDEKSCLNGIMKAIAYVPLPLSYEESDVKSIRSLESCLEDYLRVICPKKVFEEKCIYQITSLPRLYNVFE 682
4 -14.900[D] KOG1845 MORC family ATPases  ali follow..  11  101.......RVHPQFLHANATSH--KWALGALAELLDNSLDEVSNGATY--RDGKSSILIVEDNGGGMNPSTFRECLSLGYSRK----NMANRVGQYG--GFKTSTMRLGADAIVFSRSRGINGNNPTQYLSQQDLLDQFNHLEEQGTRIVIYNL-KNIDMAKTYPNSRHFLTYRHSLRSYASILYLKRPDNFRIILRGEDVEHHSVLD-----DMMKIEEKTYKPMRSPEWPDQEEMVASLKLGFVKDA--------------HHHIDIQGF----------------NVYHKNR------LIKPFWRVWNAAGSDGRGVIGI--------LEANIQPAHNKQGFERTVVLESRLVTHQKNYWSSRCHEIGYAPRRKQKNYESSVTETPRPFNNINVVKGSSSSTPVPVRVFRPNVEPSGRNQIPQVETRERSFDINPEIGAKNRSYYGLGISSFKETGSVNLEAELQKVKQESAKLVSELQRQKQLLELQESKAKIQNLEKAQREKEVLELQLKESKARIQNLENRQEGVSTIFQQERARRDVTEDGLRKKLREASDVIDGLRKQVDTFKGKR........................................................................................................................................................................................................................................ 704
5 -13.500[L] COG1389 DNA topoisomerase VI, subunit B  ali follow..  11  9....SVAEFFEKNKHILGYSNPAKAIITVVKEAVDNALDA-LPDIFVRISKVDDHFIVVEDNGPGIPREQIPKVFGKLYGSRFHEIR-----QSRGQQGIGISAAVLYAQLTVISKTPDEDRAKKVVLY----INTKKNEPEIVEEGEEEWYLPSGTKIELEVAGNYVRERKQSVYEYLRETSVINPHAKITFVEPDGTINEMSMLKSTRATTLRRFLKEEFVRVGEKIADDVLRKLSPIGEAMIAKSLMAEFQPEFVYAVTRKPKVYSGFLVEVGLAYGGEIKSEKLRYANKIPLLYQQGGCALTKAVESVNWKSYPAVIL-IHLASTNIPYT-SESKESVAAIPE--IIDETRLALQEVGRRLKEYLERKSRQQKKKKKEEMIGKVLPLIAKKVCEILEKEPLEIDRIVARIMGYLHVERIVEERDGVKVVTIRVSNFTRSKKS....................................................................................................................................................................................................................................................................................................................................................................... 530
6 -11.900[L] COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit  ali follow..  11  1MSETTNDNYGASSIKVLKGLDAVRKLHHMVFEVVDNAIDEACSDIIVTIHDDN--SVSVQDDGGGIPVD--------HPEEGVGKFDDNSYKVSGGLHGVGVSVVNALSDLQLTIRRQGHVHEQFYHLGEPQSPLTVIGETEATGTTVR----F--WPSSDIF--AITTFDYKILAKRLRELSFLNSGVSIRLIDKRDGSEDHFHYEGG---------IQAFVEYLNKNKNPIHPKPFYFTAEKDGIGV--EVALQWNDGVNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNSYMENEGMLKKEKVATSGDDAREGLVAIISVKVPDPKFS---SQTKDKLVSSEVKSAVEAMNEKMQEYLLENPADAKIIVNQIIMAARAREAARKAREMTRRKGA....................................................................................................................................................................................................................................................................................................................................................................................................................... 400
7 -10.500[O] KOG0019 Molecular chaperone (HSP90 family)  ali follow..  13  82..QAEVSRLLDLIVHSLYSHKEV------LRELVSNASDADGGDLEIRIKDPDNGTITITDTGIGMTKEEIAQSGTSKFLKALKENKD-ADNGLIGQFGVGFYSAFLVAEVVVSTKSPKSDKQYVWESVADSREETDPDNILRRGTQITL------------YLREDDKYEFTRIKNLVKNYS-----VGFPIYEGEPKKKKTTKTEKYWDWELANETKPLWMRNSKEVEKGEYNEFYKKAFNEFLDPLAHTHFTTEGEVEFRSILYIPGMGPLNNEDVTNPKTKNIRLYVKRVFISDDFDGELF------------PRYLSFVKVDSDDLPLNVS---REIL--QESRIVRIMRKRLIR............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 459
8 -9.930[O] KOG0020 Endoplasmic reticulum glucose-regulated protein (GRP94/endoplasmin), HSP90 family  ali follow..  13  78..QTEVNRMMKLIINSLYRNKEI------LRELISNASDATNPELHIRIKDKENKALHIMDSGIGMTHQDLITIAKSGTADFLAKMQD-DMNDMIGQFGVGFYSAFLVADVVVTTKHDDKQYIWESDANSFSITEDPRGDTLKRGSVISLY--------------KEEAQDFDTVRELIRKYSFINFPIRMVEEAEDEKPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKSLLYVPKVQPSESFNRYGTKSDNIKLYVRR-------ITDEFNDMMPNY------LSFIRGVVDSDDLPLNVS---RETL--QQHKLIKVIKKKLVR............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 465
9 -9.890[O] COG0326 Molecular chaperone, HSP90 family  ali follow..  13  16..QSEVKQLLQLMIHSLYSNKEI------LRELISNASDAGDGDLRVRVSDADKGTITISDNGIGMTREQVIDHLGTIAKSGTKEFKNSQLIGQFGV-G--YSAFIVADKVTVKTRAAGEEADKAVLWESAGEYSVADIEKKSRGTDVILH-------------LREDEKEFWRLREIIGKYS-----IGLPVEMLTKEYDDEGKECGEKWEKI-NKSDALWTRSKNDVSDEEYKAFYKHLSHDFVDPVTWAHNKVEGNQAYTSLLYVPA--KAPWDLFNREHKHGLKLYVQR-------IMDDAEQFIPNY------LRFMRGLIDSNDLPLNVS---REIL--QDNKITAALRKALTKRSLQ......................................................................................................................................................................................................................................................................................................................................................................................................................................................... 366
10 -7.490[T] COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism  ali follow..  19  414....TLILNSESQLPDSGSEDQVATLITTLGNLIENALEAPGGEISVTLHYRHGWLCEVNDDGPGIAPDKIDHIFDKGVSTKGSE------------RGVGLALVKQQVE------------------NLGGSIAVESEPG--IFTQFFVQ-----IPWDGERSNR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 543

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.