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Query: [A] KOG1996 mRNA splicing factor, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIADTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFSRRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEPDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKGEAQDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQVLast
1 -119.000[A] KOG1996 mRNA splicing factor  ali  100  1MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIADTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFSRRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEPDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKGEAQDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV 405
2 -37.300[A] KOG0120 Splicing factor U2AF, large subunit (RRM superfamily)  ali follow..  13  2.....GYDDRERDRERRRHRSRSRDRHRERSRDRRHHRNSRRKPSLYWDVPPPGFEHITPMQYKAMQASGQIPASVVPDTPQTAVPVVGSTITRQARRLYVGNIPFGVTE--------EEMMEFFNQQMHLVGLAQAAGSPVLACQINLDKNFAFLEFRSIDETTQAMAFDGINLKPHDYQPMPGITDTPAIKPAVVSSGVISTVVPDSPHKIFIGGLPNYLNDDQVKELLLSFGKLRAFNLVKDAATGLSKGYAITDQSIAGLNGMQLGDKKLIVQRASVGAKNAQNAANTTQSVMLSNVVTSGPPTEVLCLLNMVTPDELRDEILEDIKEECTKYGVVRSVEIPRPIEGEVPGCGKVFVEFNSVLDCQKAQQALTGRKFSDRVVVTSYFDPDKYHRREF.... 416
3 -36.300[K] KOG1548 Transcription elongation factor TAT-SF1  ali follow..  18  82......................................................................................................................................................................................SAEGYPSGSRNKKSKSENSEASPAPVINKAVYIQGLPLDVTVDEIEEVFKKCGVIAKNIDNGT-GTPKGDAL-FRSESVELAEQLKDVGGALKKKALRLRQQQMQQISSWDDVDEEVDDKRKKRFNKIVVLKHIFTLEELDKTLKDDITEEAEKCGRVTNVVLYD-----KEPDGVVTVRFSNNEEAEACVRLMQGRYFDGRVVEASIYDKVRFQKSGKHTL. 346
4 -26.200[A] KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily)  ali follow..  29  419.........................................................................................................................................................................................................................................................................KEEEELFPESERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEECGKFGAVNRVIIYQEKQGEEEDIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVYDQERFDNSDLSA.. 559
5 -22.300[A] KOG4207 Predicted splicing factor, SR protein superfamily  ali follow..  19  11.................................................................................................................................................................................................................................................................................................................DGMITLKVDNL--TYRTSPD---SLRRVFEKYGRVGDVYIPLEPHTKAP--GFAFVRFHDRSDAQDAEAAMDGAVLDERELRVRMARYGR.......... 94
6 -21.300[A] KOG2202 U2 snRNP splicing factor, small subunit, and related proteins  ali follow..  26  43...................................................................................................................................................................................................................................................................................................................SPTLLLSNMYQRPDMIEDFFEDLFEELGKFGEIESLNICD--NLADHMIGNVYVQFKEEDQAAAALQALQGRFYSGRPIIADFSPVTDFREA...... 152
7 -21.000[R] KOG0226 RNA-binding proteins  ali follow..  11  12............................................................................................................................ESELAELEQASSNSEEPASSQTHVGYDNATISAGPTTSESSAATSSAQVIQPSLLAAPPFIPIAATIAVSPFINPALGRLPTMPPVPPSIFMPPQLRAAPIMFPPRVLGIPAPATIEGAPAAIPQELLRTQALQSDIDKMNFKKQTDPFKKKIKEQQAKKKFVRSGGGQVWEDPSLAEWDENDFRVFC-------GDLGNEVSDELAKAFRKYPSFQKAKVVRESRTNKSK----FVSFRDSEDYVRAMREMDGKYVGNRPIKLRKSAWKE.......... 283
8 -21.000[A] KOG0128 RNA-binding protein SART3 (RRM superfamily)  ali follow..  9  488.........................................................................................................GTLAELDLVLEKVNSQVAHRAIRPQKKVSEKPAPAPKSKQDHIQKRTSGGEPIVKKVKGDDGGFKAPLPPSNAKSSSAVSSSNASSTPAPGSFAVQKAAPGTEDARTIFVSNLDFTTTEDEIRQAIEGVASIRFARKANSDLVHRGFAY-ENDQKAQQALLKDRVPVKGRPM----------FISANDPEKRVGFKFSTTLEKSKVFVRNV--HFQATDD---ELKALFSKFGTVTSVRRVTHKDGKPKGIA--FVDFDTEASAQKCVASGDKLMLRERELEVALSNPPVKKDKSHGKP. 771
9 -20.800[J] KOG0122 Translation initiation factor 3, subunit g (eIF-3g)  ali follow..  11  86..........................................................................................................................................................................................DAANEEAGSHLTMVSTEEILLERPRAPGTKADESKATGDGLSQLGKGGAVLMVCRICHKKGDHWTSKCPAPTDVFIDKPPTGESSTMSAAPGTGKAAYVPPSMRAGADRSAVGSDMRRRNDENSVRVTNL--SEDTREP---DLMELFHPFGAVTRVYVAIDQKTGVSR-GFGFVNFVSREDAQRAINKLNGYGYDNLILRVEW............... 288
10 -20.700[R] KOG0125 Ataxin 2-binding protein (RRM superfamily)  ali follow..  13  2.................................................................................................................................................................................................EKKKMVTQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAH-----GEQSSNSPSTQNGSLTQTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNI--PFRFRDP---DLRQMFGQFGKILDVEIIFNERGSK------FVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTP. 199
11 -20.500[A] KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15  ali follow..  24  1..............................................................................................................................................................................................................................................................................................................MSMTAGNVVFVGNI--PYDVSEQ---QMTEIFNQVGPVKTFKLVLDPETGSGK-GYGFCEFFDSETTAMAVRKLNNSELGPRKIRVEFPSNDP.......... 87
12 -20.400[R] KOG4454 RNA binding protein (RRM superfamily)  ali follow..  19  1........................................................................................................................................................................................................................................................................................................MEIKPTPSPPEERTIYVANF--SEEVDEELLEEL----IQAGPVVKVILRDVRDSNAK-----LVEFEDELSVLFAIELMNGVRLFNQELQVKP............... 86
13 -20.100[A] KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily)  ali follow..  21  2...................................................................................................................................................................................................................................................................................................................SRVYV-------GNLDPRVERELEDEFRSFGVIRSVWVARRPPG--------FLDFEDSRDARDAIREVDGKNGWRVEQSHNR............... 72
14 -19.700[J] KOG0899 Mitochondrial/chloroplast ribosomal protein S19  ali follow..  12  3..............................................................................................................................................................................................................................................SRHFATALVFLASKGFV-----------ILYWVYRFQASSMAFCTKLGGHWKQGVNVPVSSMLGSLRYMSTKLYIGGL--SPGTDEH---SLKDAFSSFNGVTEARVMTNKVTGRSR-GYGFVNFISEDSANSAISAMNGQELNGFNISVNVAKDWP.......... 143
15 -19.600[R] COG0724 RNA-binding proteins (RRM domain)  ali follow..  13  138...............................................................................................................................................................................................................................................................TNEGGVEAASEEKAGQVGGAGSIPGQYVPPSRRAGARDPSSDAYRDSRERDDMCTLKIMQVNENAD-ENSLREEL----FPFAPIPRVSVVRNKETGKSR-GLAFVTFSSEEVAEQALRFLDGRGYMNLILRVEW............... 267
16 -19.300[A] KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily)  ali follow..  24  4......................................................................................................................................................................................................................................................................................................................VYIGRL--PNRASD---RDVEHFFRGYGKLSDVIMKN---------GFGFVDFQDQRDADDAVHDLNGKELCGERVILEF............... 69
17 -19.100[R] KOG0114 Predicted RNA-binding protein (RRM superfamily)  ali follow..  17  2.......................................................................................................................................................................................................................................................................................................NKRNHIRLPPEVNRLLYVRNL--PYKITSD---EMYDIFGKFGAIRQIRVGNTPETR----GTAFVVYEDIFDAKNACDHLSGFNVCNRYLVVLYYQSNK.......... 92
18 -18.600[R] KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily)  ali follow..  13  1.................................................................................................................................................................................................................................................MADVLDIDNAEEFEVDEDGDQGIVRLKEKAKHRGSDSNTREAIHSYERVRNEDDDELEPGPQRSVEGWILFVTSI--HEEAQED---EIQEKFCDYGEIKNIHLNLDRRTGFSK-GYALVEYETHKQALAAKEALNGAEIMGQTIQVDW............... 148
19 -18.300[A] KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily)  ali follow..  17  18........................................................................................................................................................................................................................................................................................................SRSEQERSLRDSCTLYVGNL--SFYTTEE---QIHELFSRCGDVRVIVMGLDKYKKTP-CGFCFVEYYVRSEAEAAMRFVNGTRLDDRLIRVDW............... 105
20 -18.300[K] KOG2068 MOT2 transcription factor  ali follow..  19  62.....................................................................................................................................................................................................................................................................KEKIVGMTVDQERLASEGNMDRKKIQKSKPKSSDGRKPLTSVRVVQRNLVYIVGL-PLNLADEDLLQR-KEYFGQYGKVLKVSMSRTAQQFPNNTCSVYITYGKEEEAIRCIQSVHGFILDGKALKACF-QEDSFTKDEIIS.. 232
21 -18.100[A] KOG1190 Polypyrimidine tract-binding protein  ali follow..  16  3......................................................................................................................................................................................................................................................GIVPDIAVGT-KRGSDELFSTCVTNGPFIM-----SSNSASAANGNDSKKFKGDSRSAGVPSRVIHIRKL--PIDVTEG---EVISLGLPFGKVTNLLMLK-------GKNQAFIEMNTEEAANTMVNYYTSVVLRGQPIYIQFSNHKELKTDSSPNQ. 144
22 -18.000[A] KOG4206 Spliceosomal protein snRNP-U1A/U2B  ali follow..  15  7.................................................................................................................................................................................................................................................................................................................PPNQSIYIQNL--NERIKEELKRSLYCLFSQFGRILDVVALK----TPKLRGQAWVTFSEVTAAGHAVRQMQNFPFYDKPMRLQY............... 86
23 -17.900[K] KOG0147 Transcriptional coactivator CAPER (RRM superfamily)  ali follow..  15  4.................................................................................................DDFDIVIEAMLEAPYKKEEDEQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSNRSRDRDRYRRRNSRSRSPGRQLATGYRYGHSKSPHFREKSPVREPVDNLSPEERDARTVFCMQLAARIRPRDLEDFFSAVGKVRDVRIISDRNSRRSKGIACEIQSVPLAIGLTGQRLLGVPIIVQASQAEKNRLAAMANNLQKGNGGPMR-----LYVGSL--HFNITED---MLRGIFEPFGKIDNIVLMKDSDTGRSK-GYGFITFSDSECARRALEQLNGFELAGRPMRVGHVTERL.......... 327
24 -17.300[A] KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily)  ali follow..  19  4..........................................................................................................................................................................................................................................................................................................WADERGGEGDGRIYVGNL--PTDVREK---DLEDLFYKYGRIREIELKN----RHGLVPFAFVRFEDPRDAEDAIYGRNGYDYGQCRLRVEF............... 86
25 -17.100[TR] KOG4019 Calcineurin-mediated signaling pathway inhibitor DSCR1  ali follow..  18  2...........................................................................................................................................................................................................................................................................................................EEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFK-------SFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPP. 99
26 -17.000[R] KOG1457 RNA binding protein (contains RRM repeats)  ali follow..  14  83..........................................................................................................................................................................................................................................................................................................VHELKTRPGVRTLFVSGL--PVDIKP---RELYLLFRPFKGYEGSLIKLTARQP-------FVIFDSRAGAEAAKNALNGIRFDPQTLRLEF............... 167
27 -16.800[R] KOG4208 Nucleolar RNA-binding protein NIFK  ali follow..  16  1..............................................................................................................................................................................................................................................................................................................MAAFSRSAGPILSLNPQED------AELQKEVAQCDTVTRFRLSRKKRTGNSK-GYAFVEFESEDVAKIVTETMNSYLFGERLLECHFMPPEK.......... 86
28 -16.800[K] KOG4210 Nuclear localization sequence binding protein  ali follow..  10  2.......................................................................................SETELSKEDAVTKKDNEEQVKKALLDPTKKRKAEDEIEIDLKSSIPLSKKQKRLLRRGKVTLEELNAKYNIDPKSIEEYKEDAEKKKSGASEKDAQGEESTINTPTGDESGEVVKKKKKDENKYGVWIGNLSFDTTKDDLVRFFIAKTKDNEDEAAKNSNAMKNKGFCKNVEQMKAVLELSESHLNGRNMLIKDSENYSGRPDKDDLVAMSK-----NPPSRILFVGNL----DVTDD---LLRKHFQHCGDIVKIRMATFEDSGKCK-GFAFIDFKNEEGSTNELKDKSCRKIAGRPLRMEYGEDRS.......... 319
29 -16.700[R] KOG0126 Predicted RNA-binding protein (RRM superfamily)  ali follow..  19  33.................................................................................................................................................................................................................................................................................................................KDSAWIFLGGL--PYELTEG---DIICVFSQYGEIVNINLVRDKKTGKS-KGFCFLCYEDQRSTILAVDNFNGIKIKGRTIRVDHVSNYR.......... 116
30 -16.600[A] KOG4212 RNA-binding protein hnRNP-M  ali follow..  12  2.............................................................................................................................................AAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVEKVGEVTYVELLMD-GKSRGCAV-KMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTALQAGRLGSTVFVANL--DYKVGW---KKLKEVFSMAGVVVRADILEDKDGKSRGIG--TVTFEQSIEAVQAISMFNGQLLFDRPMHVKM............... 278
31 -16.400[A] KOG4209 Splicing factor RNPS1, SR protein superfamily  ali follow..  14  2.......................................................................................................................................................................................................................................SDNDIIDDDVLNIEDMTGDDADLSAIEGDLNEIEEEQKKLKAIQNEMVGHMNLN-TSSQSNSSQSLLTPEEKAEADAKSVYVGNV-------GATAEEIEQHFHGCGSVSRVTIQCDRFSGHPK-GFAYVEFTEKEGMQNAL-AMTDSLLRGRQIKVD................ 151
32 -16.400[R] KOG0110 RNA-binding protein (RRM superfamily)  ali follow..  12  4......................................................................................................................................................................................................................................................................................................................IIVKQL--PKHITED---KLRQIFGAQGTITDLQLKYTPDGKFRQFC--FVGYSTEEEAQSAIRHFDNTCIQTSRVRVES............... 76
33 -16.300[A] KOG0115 RNA-binding protein p54nrb (RRM superfamily)  ali follow..  9  99.................................................................................................................................................................................................TESQLMDEVPKKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYLSGKFAFLRLDTRAHAESAKEAIDGRIIHGRQVRV--------------------------RFAVHGAAIRVKEL--SPTVSNE---MLYHAFSHFGDVERAVHIVDEKGRPTGEG--IVEFERKPNCNEAMAAIRDKVFSPKPLICEVLEPRD.......... 272
34 -16.200[A] KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily)  ali follow..  6  2....................................................................................................................................................................................................NGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRSQNPPQSKGCC---------VTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMI--SKKCTEN---DIRVMFSSFGQIEECRILRGPDGLSRGCA--FVTFTTRAMAQTAIKAMHQAQ-CSSPMVVKFADTQK.......... 190
35 -16.200[A] KOG0146 RNA-binding protein ETR-3 (RRM superfamily)  ali follow..  10  29.........................................................................................................................................................................................SAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGML--NKQQSED---DVRRLFEAFGNIEECTILRGPDGNSKGCA--FVKYSSHAEAQAAINALHGS--ASSSLVVKFADTDK.......... 234
36 -16.100[R] KOG0118 FOG: RRM domain  ali follow..  15  157..................................................................................................................................................................................................RMNARTSMAQREDVIRRTVYVSDLDQQVTEEQLAGLFVSCGQVVDCRICGDPNSVLRFAF-TDEEGAMTALNLSGTMLGFYPVKVLPSKTAIAPVNPTFLPRTEDERE---MCARTIYCTNI--DKKVTQS---DVKIFFESFCGEVYRLRLLGDYQHSTRIA--FVEFVMAESAIAALN-CSGVVLGSLPIRVS................ 342
37 -15.900[AJ] KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily)  ali follow..  16  81....................................................................................................................................................................................................ATTPSSQKKDTSNHFHVFVGDLSPQITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQMRQTFSPFGQIMEIRVFP-------DKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQ. 286
38 -15.800[A] KOG0131 Splicing factor 3b, subunit 4  ali follow..  12  10...................................................................................................................................................................................................GANLLGQHSAERNQDATVYVGGLDAQLSEELLWELFVQAGPVVNVYVPKDRVTNLHQNYGRSEEDADYAIKVLNMIKLHGKPIRVNKASQDKKSLDVGAN---------------LFIGNL--DPDVDEK---LLYDTFSAFGVIASNPKIMRDPDTGNSRGFGFISYDSFEASDAAIESMTGQYLSNRQITVSYAYKKDTKGERHGTP. 202
39 -15.600[A] KOG0145 RNA-binding protein ELAV/HU (RRM superfamily)  ali follow..  12  36........................................................................................................................................................................................................QTGATTDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDAN----------------LYVSGL--PKTMTQK---ELEQLFSQYGRIITSRILVDQVTGV-SRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITV............... 207
40 -15.200[AJ] KOG0123 Polyadenylate-binding protein (RRM superfamily)  ali follow..  15  173................................................................................................................................................................................................FKSRKEREAELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDFGFVSYEKHEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVN--LYIKNL--DDTIDDE---KLRKEFSPFGSITSAKVMLEDGRSKG-----FVCFSSPEEATKAVTEMNGRIVGSKPLYVALAQRKEERKAHLTNQ. 381
41 -14.600[R] KOG4733 FOG: RRM domain  ali follow..  12  27...............................................................................................................................................................................SLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPHTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGDSPAAAQKAVSALKASGVQAQMAKQQEQDPTN-----------------------LYISNL--PLSMDEQ---ELENMLKPFGQVISTRILRDSSGTSRGVG--FARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQK. 229
42 -13.900[R] KOG4307 RNA binding protein RBM12/SWAN  ali follow..  15  847...........................................................................................................................................................................................................................................................................................GSRGDDSQPSQSELMELIKSIGPRGTVLSCNGF--PKDVT---LEDVVEFFNDY-EPDRNSIRIRRGDDGVMTGECMLACQNQENARRASMDLDGQKLRNSVISVRII.............. 948
43 -13.500[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali follow..  16  227.................................................................................................................................................................................................................................................................................................................RNITTLYVGNL--PEEITEP---ELRDQFYQFGEIRSIALVPRQQ---------FVQYTKRNAAELAAERTNKLVIQGRKVSIKW............... 300
44 -12.800[D] KOG2186 Cell growth-regulating nucleolar protein  ali follow..  15  404................................................................................................................................................................................................................................................................................................................DIAQRNIFVRGF--GWDTTQE---NLKTAFESYGEIEECSVVMDKDTGRGK-GYGFVMFKTRKGAREALKRPE-KRMYNRIVVCN................ 481
45 -12.500[A] KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins  ali follow..  13  4...........................................................................................................................................................................................................GTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHREVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGL--PFGCSKE---EIVQFFSGLEIVPN--ITLPVDFQGRSTGEAFVQFASQEIAEKALK-KHKERIGHRYIEIFKSSRAEVRT....... 193
46 -12.500[K] KOG3152 TBP-binding protein, activator of basal transcription (contains rrm motif)  ali follow..  12  9...........................................................................................................................................................................................................................................................................LTDGISEEKESKETMKSQKADRKKKKLKEKLLKEASKADNRGVCYLSRI--PPHMDHV---RLRHILAQYGELGRIYLAPEADTFVYCY---WVEFAKKSVAKRVADMLNGEQIGGKKKSIKYLTKFKWDD....... 162
47 -12.300[J] KOG2314 Translation initiation factor 3, subunit b (eIF-3b)  ali follow..  13  41....................................................................................................................................................................................................................................................................................................ESVYQDDQSEFDTGFGNIIVVDHLVPKEKF-EKLEGVVKKIYNQLGVIKENGLLMPVDPDTKMTGYCFIEFNTPQEAQNAKEKSHGYKLDKSIFAVNMFDDDRLMN....... 150
48 -12.200[D] KOG4660 Protein Mei2, essential for commitment to meiosis, and related proteins  ali follow..  12  164.............................................................................................................................................................................................RKRPNTAGRVSVEHPNGEHPSRTLFVRNINSSVEDSELSALFEPFGEIRSLYTACKFVMISYYDIRAAHAAMRALQNTLLRKRTLDIH-----------------SIPKENPSEKDMNQGTLVIFNV--DTTVSND---ELLQLFGAYGEIREI------RETPNRRFHRFIEYYDVRDAETALKALNRSEIGGKCIKLELSRPGGARRLSVPSQ. 354
49 -12.200[R] KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily)  ali follow..  16  1............................................................................................................................................................................................................................................................................................MAYQPVPGSGFHYLNSPFGDTTFTKVFV--GL--AWETQSE---TLRQHFEQYGEILEAVVIADKNTGRSK-GYGFVTFRDPEAARRACADIDGRRANCNLASLG................ 102
50 -12.100[K] COG5175 Transcriptional repressor  ali follow..  19  83.....................................................................................................................................................................................................................................................................DENVRYVTLSPEELKMERAKLARKEKERKHREKERKENEYTNRKHLSGTVIQKNLVNPPVPYEEVAPTLKSE-GQYGKINKIVVNRKTPHSHSPGYGVYITFGSKDDAARCIAQVDGTYMDGRLIKAAYYEADSFNKRELHN.. 269
51 -11.900[R] KOG2135 Proteins containing the RNA recognition motif  ali follow..  13  362................................................................................................................................................................................................................................................................................................................NRDNCTLQVAKI--PPEMNT--IAKLNEHFATFGTVDNIQV-----RYNGEIDSALVTYASKFDAGKAYKS-----LNNRFIKVFWHNPGG.......... 442
52 -11.700[A] KOG0533 RRM motif-containing protein  ali follow..  13  71.................................................................................................................................................................................................................................................................................................................SKVIRVNISNL--APTVISS---DLEELFGDYR-LSSVSVNFNEHGDSLGTG--DISLTK-RDAERLVQKFSGVALDGKIMKFAVIDSSN.......... 151
53 -11.500[R] KOG1995 Conserved Zn-finger protein  ali follow..  15  250......................................................................................................................................................................................................................................................................................APRRQEASYEDAATEKVKQCDADCDDNCDNARIYISNL--PPDVTTD---ELKDLFGGIGQVGRIKIYTDEKGNYKGDA--CLAYEDPSAAHSAGGFFNNYEMRGNKISVTMAEKSAPRAPTFDQS. 382
54 -11.400[AR] KOG1365 RNA-binding protein Fusilli, contains RRM domain  ali follow..  10  252.........................................................................................................................................................................................AGLDEFMHVATGSSTEAMEFVSANAIIVRMRGLPYDCTDAQIRTFFEPLKLTDKILFITRTGRPTGDAFVQFETEEDAQQGLLKHRQVIGTAAEVQQVVKRCNLINSSPAVANAVEAPEEKKKDCVRLRGL--PYEATVQ---HIVTFLGDFATMVKF-VHMVYNNQGHPSGEAFIQMINEQAASACAAGVHNNFMSKRYIEVFQASAEELNL....... 474
55 -11.300[R] KOG2295 C2H2 Zn-finger protein  ali follow..  10  237.GTIGSVDSSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNG-------------------------------DGSKVEEDGEKPSVGKDKVVETETIDLDKVKDGQPRALHRTSSIFLRNL--APSIT---RSEIEAVCNRFSGYLRVAIADPLVERR------WITFMRDVNIKEICWGLNNQRLRDCEMGAI................ 589
56 -11.200[A] KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily)  ali follow..  13  131.............................................................................................................................................................................................................ASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRG----AFVEYESHRAAAMARRKLLPGRIQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNL--MLSTSEE---MIEKEFNNIKPGAVERVKKIRD---------FVHFSNREDAVEAMKALNGKVLDGSPIEVTLAKPVD.......... 305
57 -11.200[A] KOG4676 Splicing factor, arginine/serine-rich  ali follow..  21  29................................................................................................................................................................................................................................................................................................................GGGTEVIQVTNV-SPSASSEQMRT------GFLGKIDELRLFPPDDSPLPVSSRVFVKFHDPDSAVVAQH-LTNTVFVDRALIVV................ 108
58 -11.000[T] KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains  ali follow..  9  144...............................................................................................................................................................................KEVEEVIPQVVQPTEQVDEVAEPVTIPTQQPEAKQTTENTVKKPERAVANGHPKTQEDNVVNDKSNGVDAPKKSFAHIVQDLAQNGATFNAKASPAKPKSKPVTKPSAARESKAPAPVSEHSSAATIDQQAEGYTIFVANL--LMDATPE---QLNETFKGFGAITKDGIQVRSYRLKGNC---FVTFASAEAVKLVLQAHKES-IGNRRVSIE................ 353
59 -10.400[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  10  194................................................................................................TSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTR-----ATDLKNLFSKYGKVVGAKVVTNARSPGA-----FVTMSTAEEATKCINHLHKTELHGKMISVE................ 480
60 -10.400[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  13  106...................................................................................................................................................................................................................................................KTRNIDHFVEELKREQEIRERRNQDRENSRDHNSDNTSSSRFDELPDYFDPSGRLGSLDDGDPQTTNLYVVNL--SSKVDEN---FLLRTFGRFGPIASVKIMWPRTEEEKRRER-FVAFMNRADGEAAKEKMQGIIVYEYELKIGW............... 249
61 -9.760[R] KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains  ali follow..  8  340.............................................................................................................................................................................................................................................................................................EISKDQSMELEKLGAHMVGMTPCDTLLIRGL--PDGINNS---LIFDSLGALVCLSSISMIK----LSESKRFAYLQMKSADEAKMLLNLTYKSPIKDKDVQVSW............... 437
62 -9.720[AR] KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains  ali follow..  9  5.........PAAPRPPAGPAASM-------RCAPNAGSGPEAERSAAPSAGPPGPPLRPLGADPCVSPGSDPASPSSRPASRAQALRGPPKSRSPARLAARPQQPSAQKGHAAHGRAEREVPESAVARLCPRGCLRGAVPFLPRPRGPELLAGSEISADPVICCPRGSGLATPRTLSGKWLTDEGRASSGCLNPNRCKPAPHAEGVGAGSRGGARAQSVLSPSGDSREGDLLQFASSERARLTPMIPRPRLLRI-HGAFRTKRFSVRDKEDQWTVSVQRQLVYRPSTEAGHNNKELPPPLPPRGACPDDEAV--HQKPAPGGHRAGDPLS----QAVGKVLECDIIK------------FVHIEDKTAAEDTIHNLHHYKLHGVNINVEASKNKSKASTKL.... 381
63 -9.640[A] KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1  ali follow..  14  29..................................................................................................................................................................................................RLNADSDDGSHGSQDPGKMFIGGLSWQTTAENLRDYFGRFGEVNECMVMRDPATKRARGFG---------ITFVDPSSVDKVLNNREHELDGKKIDPKVAFPKRTQAKLVTKTKKVFI-------GGLSATSTLEMKQYFETYGKVEDAMLMFDKATQRHRG---FVTFDSDEVADKVCEIINGKMVECKKAQPK................ 212
64 -9.310[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  9  63......................................................................................................................................................................................................................................................................................SGEPGERNSGGPNGVYHQSSGSLTPTMNRRYQLYVGNL------TTD--QDIANSLRDIGDLQEVKFFENRANGQSK-GFSVISLGSESSLRAVLDQLPKKEMHGQAPVVTYPSKQALTQFESLQK. 184
65 -9.120[A] KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain  ali follow..  15  13................................................................................................RIDDDDDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDDERPSFGGKRARDYSAPVNFISAGLKKGAAEEAELEDSDDEEKPVKQDDFPKDFGPRKLKTGGNFKPSQKGFAGGTKSFMDFGSWERHTKG--IGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQSMQDFPVVDSEEEAEEEFQKELS................................................................................................ 223
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;