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Query: [O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYRAGAVLLRGATRTRLLAAASAHQSFATFSQRNQSILMMKSMELAGNSGERRFYSTHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRALEPIDEITPKNETPLNGRRARGKRAASATSPLTPPPSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKILCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVRTALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMTGEISLTGKVLPVGGIREKVIAARRVGAKRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQLast
1 -198.000[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali  100  1MYRAGAVLLRGATRTRLLAAASAHQSFATFSQRNQSILMMKSMELAGNSGERRFYSTHDDPIAVDDSLELYKDLGGMSPIQVPADMPNVPMLAINRYPLFPGFIKKVDIVKDDNLKALIRRQLSLKQPYAGVFVKRDDENKEETITSLSEVYPTGSFVQIIEVRDQGSVLELVLSAHRRIRALEPIDEITPKNETPLNGRRARGKRAASATSPLTPPPSPPPLAPSVASVAPEISATEEKEEKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTSVPWGLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGKILCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKMIQCMKKVKTENPLVLIDEVDKIGGAGFHGDPASALLELLDPEQNANFNDHFLDVPVDLSRVLFICTANEISKIPGPLRDRMEMIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVIMGLAWTAMGGSALYIETVLKRPVDLTNDKDGSIETTGNLGDVMKESVRTALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAGVTLVSSLLSLALDRPVVQDMAMTGEISLTGKVLPVGGIREKVIAARRVGAKRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDELYEHLFQ 971
2 -158.000[O] COG0466 ATP-dependent Lon protease, bacterial type  ali follow..  37  2..............................................................................YTEQAENNRESLIMPLFEVVVYPKGRAKFLADKVTGEILLAEMKTTEAVYAVGLTVKSGTKPSEI---SEDSLYKTGNLLKIGYVQPA-------------------------------------------------------------------DDGYLVIAKAVQKVEAVSVYRKNGLFYAMFKPVFDIP-DLDEDIQAEMMANIKKAIREISSRFQGSEQFTKPIEK----MDSIDQLIGYVMPYMP-IKLEEKQALLEIVSVRERYFAFFEILMKQKENINFQMEMAKKVTDKISKSNREAMLREQLKMIQEELNGGDDAAS-GEGGYRERIEKSTMPEEVKKKALSELKKLETGGPHNPESSVIRNYLDLMLDLPWVTEEKKSIDIDEARRVLESNHNGLEKVKERIIQHLAVMKLKKEKQGSILLLTGPPGTGKTSLGKSIADALGREYVRISLGGVRDEAEIRGHRRTYIGALPGRIIQGMRKAGTKNPVFILDEVDKLS-TSYAGDPASALLEVLDPEQNNTFSDHYLEVPYDLSEVFFIATANSLASIPWPLLDRMETIEISGYTKNEKLAIAKDHLLPCILEEHGLDADKLKIEDEALKGIIDKYTREAGVRGLKKQLARTARFVSEKIVSGKTD----------------------------------LPYVVRADMLKEVLGKEIIRQEEARKENVPGVVTGLAWTPVGGDILFIEGTFM-------PGNGKLTLTGQLGDVMKESAQISLSLVRSRLASTENSFN-FTASDVHIHVPSGATPKDGPSAGVTLFTALTSLITGKAVDPKLAMTGEITLSGAVLPVGGIKEKVLAAHRAGIKKVILPKENERDLEDVPEEVRNELKFVPVETIEEVLKEALG 774
3 -85.200[O] COG4930 Predicted ATP-dependent Lon-type protease  ali follow..  13  2........................................................................................................................................................................................................................................................................................................QTHHDLPVPAVSEGELVAEGYDLDALLNQHFRG-RVVRKDLTKQLKEGANVPVYVLEYLLGMYCASDDDQIVEQGLQNVKRILADNYVRPDEAEKVKSLIRERGSYKQLSNLGIKDALVPPQMVKDNEKLLTGGIWCMITVNYFFEEGQKTSPF-SLMTLKPIQMPNMDMEEVFTARTLLRSVGMEPANIEQRTKWHLITRMIPFVENNYNVCELGPRGTGKSHVYKECS-----PNSLLVSGGQTTVANLFYNMASRQIGLVGM-----------WDVVAFDEVAGITFKD--KDGVQIMKDYMASGSFSRGRDSIFVGNINQSVETLVKTSHLLAPFPAAMIDTAFFDRFHAYIPGWEIPKMRPEFFTNRYGLITYLAEYMREMRKRSFSDAIDKFYKLGNNLNQRDVIAVRRTVSGLLGSYSKEDVRVCLTYAMEARRRVKEQLKKLGGLEFFDVNFSYIDNETLEEFFVSVPEQGGSELIPAGMPKPGVVHLVTQAESGMTGLYRFETQM------TAGNGKHSVSGLSSTSAKEAIRVGFDYFKGNLSRVSATAK-FSEHEYHLHVVELHNTGPSTATSLAALIALCSVLLAKPVQEQMVVLGSMTLGGVINPVQDLAASLQLAFDSGAKKVLLPMSSAVDIPTVPAELFTKFQVSFYSEPVDAVYKALG 692
4 -53.400[O] COG1067 Predicted ATP-dependent protease  ali follow..  12  112.............................................................................................................................................................................................................................................................................................................................QFRQDIEKLMTKLV-TAIPLAFDNEIYFSRAEKLKNQLAQK------QESELESITRTAKERGVSLTLTPQGEYQFVALNGEEMHTEETFDALSKR-EQEQFSNTIDELEVSLRNMVRQLT--EWEESYSEKIKKLNDEVTLDVIAHFIKKLKLDYSKYPEIKAYLTELQKDIVENVEIFLDEGADQGELANASLDKKMPRRYKVNVLVSRNAEEFYHSLFGYIETATYKGTVFTDFSLIRPGSLHKANGGVLLMDAVKVLEQPYVWDG--LKRALRSRQLSFTSLEKEVTLTGTVSLDPEPIPKIILFGDYRTYELLAHYDPEFSELFRVTADFADEMPRDADSELYARFISSIVHDANMLHCDRKAIARIIEHSSRTTGDQTKLSLHSAHIANLLRE---------------------------------SNYVAKQANANLIRQIHVEEALRNQELRVNRLQQSVAIGQVNALSVLATSDHAFGMPNRI---TATTSYGEGEIIDIERNVDLGGSIHSKGVMILSAYLSSVFGRTARI-PLTTTITFEQSYGGVDGDSASMAEFCAIVSAFSKQPNRQDIAITGSMNQFGESQPIGGLNEKIEGFFDKDTQGVIIPRSNMHNLMLRADVVKGEFHIWAIDHVTEAIEIFT. 755
5 -43.600[O] COG1066 Predicted ATP-dependent serine protease  ali follow..  14  45......................................................................................................................................................................................................................................................................................................................................................................................................................................................................SAKGDRFSGYAGETRAKIQTLAEISLQETPRFSSGFHELDRVL--GGVVPGSAILIGGHPGAGKSTLLLQVMCGLAQNMTALYVTGEESLQQVAMRAKRLGLPTDKLNMLS-----ETSVEQICQLADQLKPQ----------IIVID-------------------SIQVMHLADIQSSPGSVAQVRECASFLTRYAKTRQVAIIMVGHVTKDGTLAGPK--------------VLEHCIDCSILLEGEADSRTLRSHKNRFGAVNE-----------------------------------LGVFGMTEQGLREVKNPSAIFLSRGEEQTPGSSVMVIWEGTRPLLVEIQALV-------DHSMLANPRRVAVGLEQNRLALLLAVLHR--------HGGLQMSDQDVFVNVVGGVKVTETSADLALLLALISSFRNRPLPQDLVVFGEVGLAGEIRPVPSGQERIGEAAKHGFKRAIVPFANR------PKSAVPNMDVFTVKKLSDALAILEN 458
6 -31.200[R] COG1750 Archaeal serine proteases  ali follow..  20  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSALKILALMLILITPAGAQFENAQKASIKAVAVTSGDQPTGVVINISVIVT-------PGDGRVFVTTPYTEIMQGSAQLAAITACDLLGI-------FTKYDFFYIIEAEAPIVGGPSAGGVLTVATVAALKNLTIRDDVYMTGMIYPDGYIGPVGGLKYKLEAAAKNGAKIFLIPQGQRITYVEEKKVRRVGIISYIEVEYKELDLVEY. 202
7 -28.600[T] COG3480 Predicted secreted protein containing a PDZ domain  ali follow..  14  2.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKKIRWPLY-AALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAVTVGVQHATLAHMIYAWLTPFTDIRSAQE----TTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAG------------------------------------KDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTFDSSKDLIDYV-------SSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSLAIYTQIAHPDLRNGVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNNYQTALEAAKTIKTDMKIVPVKTLQDAIDYL.. 341
8 -18.200[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  14  418.................................................................................................................................................................................................................................................PGCGKRTVVKYVARRLGLHVVEFSCHSLLASSERKTSTALAQTFNMARRYSPTILLLRHDVFKNLGSQDGSLGDRVGVSFEIASVIRELMEEKSNSNFSENEVGKFRGHQVLLIASAESTEGISPTIRRCFSHEINDEQRSEMLSQSLQGVSQFLNISSDEFMKGLVGQTSGFLPRDLQALVADAGANLYISQESETKKINSTEKLTAKEDFTKALD-KKRNASALGAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLFSS-VLLYGPPGTGKTLLAKAVATECSLNF--LSVKG----PEL----NMYIGESEKNVRDIFEKARSARPVIFFDELDSLAARGASGDSGSQMLAEID------------GLSDSSQDLFIIGASNRPDLIDPALLDKLLYVGVN--DASYRERVLKALT------------RKFKLSEDVSLYSVAKKCPSTGA-----DMYALCADAWFQAAKRKVSKSDSGDMPTEEDDPDSVVVEYVDFIKAMDQLSPS----LSITELKKY......................................................................................................................................................................................................... 961
9 -17.100[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  12  7....................................................................................................................................................................................................................................................................................................SLSRDLERKIHERLVSLKDTIQQTEIEEWPVSTRRAIQFVQERDMSLRRIKLDTLKAEVEEKLASSQDLVLVDSDMEEQSDSNLMEVKDTNVINKSITSLWSSPNLKEIDGEDEKKSVGQESITGSAKRKDRRSKTNGSKR-----------QKAEANREPPSDISL------------------SDIGGLDDCINELLELVAMPIKHPEVYQYTVLLHGPPGCGKTMLANALANELGVPF--ISISA----PSI----SGMSGESEKKVREVFEEAKSLAPLMFIDEIDAVTRESAQREMERRIVAQFLTC-----MDELSFEKTDGKPVLVIGATNRPDSLDSALRGRFDEICLTVPSQDAREKILRTMAKGLKLSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPLNSDPRFNELDSDMALDSNDSLPLDHSSIIQRYLNAHPDPLSPEELEPLAICPQDFIEALAKVQPSSKREGFATVPGV----SWNNIGA---AIVQPIKRPELYQSPGCGKTLLAKAVANESKELLNKYVGESERAVRQVFLRARASSPCVIFFDELDAMVPRRDDSLS-RVVNTLLTELDGLSDRSGVYVIAATNRPDIIDP---------AMLRPG-KTLLVDLPDAHERVEILKTLTKQTPLHEEVNLDVL...... 687
10 -16.400[O] KOG0740 AAA+-type ATPase  ali follow..  19  308...................................................................................................................................................................................................................................................................................................................................................................KKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIEL-----------IMNEIMDHGPPVNW------------------EDIAGVEFAKATIKEIVVWPMLRPDIFTGLILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSK---------WVGE---KMVRALAVARCQQPVIFIDEIDSLLSQRGDGE-----------ESSRRIKTEFL-VQLD-DRILVVGATNRPQEIDEAARRRLV----------KRLYIP----LPKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSG-----ADMTQLCRGASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPS---------VSPKDLELY-----------------------NWNKTFGC.......................................................................................................................................................................... 672
11 -16.300[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  15  302...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................GKATITRADKHSKNKIYFKDVAGCDEAKQEIMEFLKNPKKYEDLGAKIALLVGPPGTGKTLLAKATAGESGVPF--LSISG-SDFMEM------FVGVGPSRVRHLFQEARQAAPIIFIDEIDAIGRARGRGGLGG------NDERESTL--NQLLVEMD-AGVVVLAGTNRPDILDKALLDRQITIDKPDI--KGRDQIFKIYLKKIKLDHE-LAALTPGFAGADIANVCNEAALIAARHEGATVTMAHFESAIDRVIGGLEKKNRVISKLERRTVAYHESGHAVVGWFLEHAEPLLKVTIVPRGTFAQYVPNENLLMTKEQLFDMTCMTLG----RAAEQVLIGKIS-----------------TGAQND-LEKVTKMTYAQVAVY----------------------GFSDKVGL---LSFPPRDDGYDFSKPYSNKTGAIIDEEVRDWVAKAYERTVELVEEHKVKVAEILLEKEHQDDLLKI......................... 754
12 -16.100[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  15  266.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................GLDSAVDPVQMKNVTFEHVKGVEEAKQEVVEFLKNPQKFTILGGKLILLVGPPGTGKTLLARAVAGEADVPF--YYASG-SEFDEM------FVGVGASRIRNLFREAKANAPVIFIDELDSVGGKPYSRQTINQLLAEMD-----GFKPN--------EGVIIIGATNFPEALDNALIDMQVTVPRPDV--KGRTEILKWYLFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPT---LGHVSLLPENDRWNETRAQLLAQMDVSMGGRV--AEELIF--------GTDHIT-TGASSD-FDNATKIAKRMVTKF--------------------------------GMSEKLGVMTYSDTGKLSPETQSAIEQEIR-----------ILLRDSYERAKHIL--KTHAKEHKNLAEALLTY-ETLDAKEIQIVLE.... 709
13 -16.100[O] KOG0741 AAA+-type ATPase  ali follow..  13  76...............................................................................................................................................................................................................................................................................................................................................QEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSNDSNPYDTDKMAAEFIQQFNNQAYSVGQQLVFSFNEKL--FGLLVKDIESMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQINPDWNFEKMGIGGLDKEFSDIFRRAFAFRVFIHVKG--ILLYGPPGCGKTLLARQIGKMLNAREPKVVNG-----PEILN---KYVGESEANIRKLFADAEEEQRIIIFDEIDAIGSTGVHDTVVNQLLSKIDGVEQ-------------LNNILVIGMTNRPDLIDEALLGRLEVMEIGLPDEKGRLQILHIHT--ARMRGHQLLSADVDIKELAVET-LEGLVRAAQSTAMNRHIKA----STKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHGKTALAAKIAEESNFPFIKICSPDKMIGAMKKIFDDAYKSQLSCV------------VVDDIERLLD-------PIGPRFSNLVLQALLVLLKKAPPQGRIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLL----KDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQ 719
14 -15.700[O] COG0464 ATPases of the AAA+ class  ali follow..  16  200.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAMEIISEQNIPTVMYEDLGGLKDAISKVREMIELPLKHPELFDRLVLLQGPPGTGKTMLAKAVANESDAYFISIN-------PEI----SKYYGESERAIREIFEDAEKNAPIIFLDEIDSIAPKRAEVTGEAQLLSLMDGLKAR-------------KNVIVIGATNRPEALDIALRGRFDEIELRVPDTEGRLEIFQIHTRGMPLADNVNLMDFAQITYGFVGADIAALCREAAMSALRRILPKILNEPEISKEILDALQVTREDFENALKDVQPSAIREILIEVPNVSWEDVGGLERVKELLKEVVEWPLKNPESYRDEAPKGV---LLYGPPGGKTLLAKAIAHESDANFITAKGSDLLSKWYGEVFTRARQVAPSII----------------DELDSLAPIRGTSVGEPQVTARILNQLLSEMDGLEELRAVVVIGATNIDPALLRPGRFDELI-EGARREIFRVHTALAEDVDIEKLVSFTDQYTGADIAAVCKKAGRHALR 711
15 -15.500[O] KOG0737 AAA+-type ATPase  ali follow..  12  209...........................................................................................................................................................................................................................................................................................................................................LRDVEKLCQSERFYKLFQRLLTKLSGPVLVLEVGEGISALFPYNIEDENQLMSWKTRFEDDMKVIQFQDNKNHIAEVLAANDLECDDLGSICHADTMFLSSHIEEIVVSAISYHLMNNKEPEYKN----VAPDNEFEKRIRPEVIPADIGSLDETKESLQELVMLPLRRPDLRG--ILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSK---------WFGEDEKNVRALFTLAAKVSPIIFVDEVDSMLGQRTRVGEHEAFMTHWDGLMSNA------------DRILVLAATNRPFDLDEAIIRRFEMVGLPS--VESREKILRTLLSKEKTENLDFQE---------LAQMTDGY---SG-----SDLKNFCTTAAYRPVRELIKQECLKDQERRKREEAEKNSEEGSEAKEEVSEERGITLRLSMEDMKVAKSQ-----AASFAAEGAGMNELKQWNDLYGE.......................................................................................................................................................................... 713
16 -15.100[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  17  87...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................VESDPRVIETEIVRDITLDDVVGQEEAKRKAKVILEYLRNPEKFGKWAVLFYGPPGTGKTMMAKALSNEAKTPFLSVK----TKLIGE------HVGDGARRVHELYERARQLAPIVFLDEFDAIALDGDVSEIVNALLTELDGTNSN-------------EGICTIAATNRVELLDASIRSRFE-IEFRLPSYEERLEILRRNLEEFPVPVKGFSGRDLVVIKASLHKAIAEGKDKIETEDLLTAAEKVKMPSRQP............................................................................................................................................................................................................................................................... 346
17 -15.000[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  16  180............................................................................................................IGRDEEIRRAIQVLQRRTKN---VLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSLDMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLARGELH-CVGATTLDEYRQYIEKDAALERRFQKVFVGEPTVEDTIA-ILRGLKERYEIHHHV--QITDPAIVAAATLSHRYVSDRQLPDKAIDLIDEAASSIRMEIDSKPQPLDRLERRIIQLKLEQQALQKEDDDASRLEKELGEKEREYAELEDVWKAEKAALSGTQHIKAELDSAKTQMEQARRASDFAKMSELQYGVIPALEKQLAQAEEIAEVLSRATGIPVAKMMEGEKELLRMEEELHKRVIGQHEAIEAVSN--AIRRSRAGLSDPSFLFLGPTGVGKTELCKTLANFLENAMVRIDMSEFMEKSRLVGAPPGYVG---GYLTEAVRR----RPVILLDEVEKA-----HHDVFNILLQVLD---DGRLTDG----TVDFRNTVVIMTSNL-QHFRPEFINRIETVVFHPLGKENIREIATIQLLIKRMESHGYQ---LHFTDACLDFIGEVYDPVYGARPLKRAIQQIENPLAQQILSGK.......................................................................................................................................................................................................................................................... 835
18 -15.000[O] COG0465 ATP-dependent Zn proteases  ali follow..  17  136.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSKARMLTEDQIKTSFADVAGCDEAKEELVDYLREPSRFQKLGGKIVLMVGPPGTGKTLLAKAIAGEAKVPFFTIS----SDFVEM------FVGVGASRVRDMFEQAKKAAPIIFIDEIDAVGRQRGAGLGGG------HDEREQTLNQMLVEMD---EGIIVIAATNRPDVLDPALLDRQVVVGLPDV--RGREQILKVHMLDTDIDASVIARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRA---LGVTFFLPEGDAISASRQKLESQISTLYGGRL--AEEIIY--------GPEKVS-TGASND-IKVATSIARNMVTQW----------------------GFSEKLGP---LLYAEEEGEIFLGRSVAKAKHMSDETARI-----IDQEVKLLVERNYQRARKLL--LENMDVLHSMKDALMKY-ETIDAPQIDDLMN.... 594
19 -14.200[O] KOG0730 AAA+-type ATPase  ali follow..  12  317...................................................................................................................................................................................................................................................................................ESESNLRKAFEEAEKNAPSIIFIDEIDSIAPKREKTNGEVERRIVSQLLTLMDGLKSRAHVIVMGATNRPNSIDPAL------RRFGRFDREIDIGVPDEIGRLE--------LRIHTKNMKLAEDVDLERISKDTHGYVGADLAALCTEAALQCIREKMDVIDLEDDNSMAVSNEHFHTALGNSNPSALRETVVEVPNVSWEDIGGLENVKRELQETVQYPVEHPEKFEKFVLFYGPPGCGKTLLAKAIANECQANFISVK-------PELLT---MWFGESEANVREIFDKARQSAPVLFFDELDSIAAGGAADRVLNQLLTEMDGMNAK-------------KTVFIIGATNRPDIIDSALLGRLD-IYIPLPDEDSRLNIFKACLRKSPVAKDVDVTALAKYTQGFSGADITEICQRACKYAIRENIEK---------------------------DIENERRRSQNPEAMEEDMVDDEVSEIRAAHFEESMKY---------------ARRSVSDADIRK----------------------------YQAFAQTLQQS-------------------------RGFGSEFRFDSTAGVGRTTGVAAAD-----------FATSAAAADDDDL.......................................................... 841
20 -13.700[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  17  374..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................CHKQSELEKAKATLLLAT-CRSKEMEEITAFIKGSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKAEVEAGSVSPYC--VEINGLKLASPENIYSVIYEGLSGHRVGWKILLIDELDVLVTRN-----QSVLYNILDWPTKPN------------SKLVVLGIANTMD-LPEKLLPRIQRLCFGPYNHRQLQEIISTRL-----------EGINAFEKTAIEFASRKVAAISG--DARRALE-ICRR-AAEVADYRLKKSNISAKSQ----------------------------LVIMADVEVAI-------QEMFQAPHIQVMKSVS-----------SRIFLTAMVHELYKTGMAETS--FDRVATTVSSICLT-------------------------------NGEAFPGWDILLKIGC---------DLGECRIVLCEPG----HRLQKLQLNFPSDDVAFAL---KDNKDLPWLANYL..................... 771
21 -13.600[L] KOG1968 Replication factor C, subunit RFC1 (large subunit)  ali follow..  10  251..............................................................................................................................................................................................................................................................................................................................................................ILETLTRQ-EATDLIKQYGGKVTGAPSVRTDFILLGENAGPRKVETIKQHKIPAINEDGLFYLITHLPASGGTGAAAQAAQQKKEQEEKKILETVARMD------SQIW----TSKYAPTSLKDIC-----GNKGVVQKLQKWLQ-PGPDGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASDTRSKRLLD---EQLFGVTDSQSLAGYFGTKANP-VLIMDEIDGMSSGDRGG--VGQLNMIIKK-----------------SMIPIICICNDRAH--RPLDRTTFDLRFR--------RPDANSMRSRIMS---AYREGLKLSPQAVDQLVQ--GTQSDMRQIINLLSTYKLSCSEMTPQNSQAVIKNSEKHIHGGMFHPSSKSTINDKLELYFNDHEFSYLMVQENYLNTT--RQEPPKMSHLKHLELISSAANSFSDSDLV---------------------------SMIHGPQQHWSLMPTHALMSCVRPASFVAGSGSRQIRFTNWLGNNSKTNKLYRMLREIQVHMRLK------VSANKLDLRQHYIPI--LPVKLSTGHSDVVPEIILNREDFDSITEL......................... 815
22 -13.600[O] KOG0743 AAA+-type ATPase  ali follow..  14  151....................................................................................................................................................................................................................................................................................................................................................................RDKVLNSYLTHVVAESEEIKRNLRVVKLYSRDVYASDDDDGMAGGNWGCINLEHPSTFDTLAMDPNAKKKIIDDLERFLKRKEFYKRVGK-RGYL----------------------------------------------------------LYGPPGTGKSSLIAAMANYLKFDVFDLELSSIYDNGEL----KRVLLSTTNRSI------------LVIEDIDCNAEVRDREAENSGILNFIDGLWSSFGDER-----------IIVFTTNHKERLDPALLGRMDVINMSYCTGLGFRTLVSNYLIEALVDSTEVTPAELA------EELMQDDDTDVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGKGKARSSKNLTMVIDEIIGFKRNQVFDAAEVYLRNKIGPET-LRWTYVESENEASQKEKRYYELTFEKKLRDKVMNSYLSHVVAESEETKRD-FETLAMDPGAKKKIIDDMERFLKRREGKAWKRGPGTG-SLIAAMANILLSTTNRSILVIYGRVTLSGLLNFVDGL------WSSFGDERIIVFTTNHKERLD-PALLRPG.................. 872
23 -13.300[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  20  167............................................................................................................................................................................................................................................................................................................................................................................................................................................................................DPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMVILYGPPGTGKTLLAKAVANQTSATFLRVV-------SEL----QKYLGDGPKLVRELFRVAEEHAPIVFIDEIDAVGTKRYDSNSGGELLNQLDGFDSR-------------GDVKVIMATNRIETLDPALIDRK--IEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKES........................................................................................................................................................................................................................................................... 424
24 -13.300[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  17  30...............................................................................................................................................................................................................................................................................................................................IALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTY------------------SDVGGCKEQIEKLREVVETPLLHPERFVNLVLLFGPPGTGKTLCARAVANRTDACFIRVI-------SEL----QKYVGEGARMVRELFEMARTKKALIFFDEIDAIGGARFDDGAGGTMLELIN-----------LDGFDPRGNIKVLMATNRPDTLDPALMGRLD-IEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSAT................................................................................................................................................................................................................................................ 426
25 -13.200[O] KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases  ali follow..  13  184............................................................................................................IGREDEIRRTIRVLSRRTKN---VLIGEPGVGKTSIAEGLARRIIDDDVPANLSNCKLLSLDVGSLVAGSKFRGEFEERIKSVLKEVEESETPIILFVDEMHLLMGAGSGGEGGMDAANLLKPMLARGKLHCIGATTLAEYKKYIEKDAAFERRFQIILVKEPSIEDTIS-ILRGLKEKYEVHHGV--TISDRALVTAAHLASRYLTSRRLPDSAIDLVDEAAAAVRVTRESQPEVLDNLERKLRQLRVEIRALEREKDEAKAARKEAEQVEEETRPIREKYELEKSRGSELQDAKRRLDELKAKAEDAERRNDFTLAADLKYYGIPDLQKRIEYLEQINEIVARWTGIPVTRLKTTEKELLNMEKVLSKQVIGQNEAVTAVANAIRLSRSDPNQPIASFLFCGPSGTGKTLLTKALASFMENAMIRIDMSEYMEKSRLIGAPPGYVG---GQLTEQLRR----RPVILFDEIEKA-----APEVLTVLLQVLD---DGRITSG----VVDAKNAVIIMTSNL-GFFRPEFLNRISIVIFNRLRRVDIRNIVENRIVQKRLQSNH-RSIKIEVSDEAKDLLGSAYSPAYGARPLNRVIQNVLNPMAVLILNGQLRDKETAHVVVQNGKIFVKPNHEANANGSADIDMDGIDDDVNDEELE........................................................................................................................................................................................................... 905
26 -13.100[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  16  26.................................................................................................................................................................................................................................................................................................................................................TRATRLLDNEIRILKEDAQRTNLECDSYKEKIKENQEKIKLNKQLPYLVGNIVEILEMNPEDDAEEDGANIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDSLKVGVNKDSYLILDTLPSEYDSRKAMEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKERFEKLVLLYGPPGTGKTLMARACAAQTNATFLKLA-------PQL----QMFIGDGAKLVRDAFQLAKEKAPIIFIDEIDAIGTKRFDSEVSGELLNQLDGFSSD-------------ERIKVIAATNRADILDPALMDRK--IEFPHPTEEARARILQIHSRKMNVHPDVNFEELARSTDDFNGAQLKAVCVEAGMLALRRDATEVNHEDFNEGIIQVQAKKKAS................................................................................................................................................................................................................................................... 419
27 -13.100[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  14  4............................................................................................................................................................................................................................................................................................................................LQFSNMVEPTGPAIVEDERTKALNSYRRKLAECRDIEQKLKDLKESEMTKQFDKSENDIKSLQSVGQIVGEVLKQLSEEKFIKATNGPRYVVGCRRSINKEELKQGTRVSLDMTTLTIMRQLPREVDPLVYKMSHEDPGNISY------------------SDVGGLAEQIRELREVVELPLINPELFKRVCLLFGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDK---------YIGESARMIREMFNYARDHQPIVFMDEIDAIGGRRFSEGTSAELLNQLDGFDSL-------------GKVKVIMATNRPDTLDPALLGRLD-IEIGLPNEQSRLEILKIHSNKITKHGEIDFEAVVKLSDGFSAADLRNVCTEAGMFAIRAEREFVIDEDFMKAVRKVGDAKRLE................................................................................................................................................................................................................................................... 398
28 -12.900[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  15  32......................................................................................................................................................................................................................................................................................................................................................................GRLKSLERQLEFTDIQEEYVKDEQKNLKRELLRAQEEVKRIQSVVIGQFMEMVDQNNGIVGSTTGSNYYVRILSTINRELLKPSASVALHRHSNALVDV--ADSSISLLSQSEKPDVSYNDIGGCDIQKQEIREAVELPLTHHELYKQIVLLYGPPGTGKTMLAKAVANHTTAAFIRVV-------SEF----QKYLGEGPRMVRDVFRLAKENAPIIFIDEVDAIATARFDAQTGAELLNQMDGFDQT-------------VNVKVIMATNRADTLDPALLGRLD-IEFPLPDRRQKRLVFQVCTSKMNLSDEVDLEDYVSRPDKISAAEIAAICQEAGMHAVRKNRYVILPKDFEKGYRANVKKPDTD................................................................................................................................................................................................................................................... 403
29 -12.900[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  15  45.....................................................................................................................................................................................................................................................................................................................................................................QAQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLKVHPEGKFVVDLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTY------------------EMVGGLDKQIKEIKEVIELPVKHPELFDALVLLYGPPGTGKTLLARAVAHHTECTFIRVS-------SEL----QKFIGEGSRMVRELFVMAREHAPIIFMDEIDSIGSSRIESGSGGELLNQLDGFEAT-------------KNIKVIMATNRIDILDPALLGRID-IEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEK................................................................................................................................................................................................................................................... 396
30 -12.800[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  15  19.........................................................................................................................................................................................................................................................................................................................................................ERVREKIRMLNSETRILQSRNTIKHDISTKNASIAENMERIRLNKQLPYLVGNVVEVLDEHSGVVNASTRMSSYLPITGLIPNSELRPGDLVALHKDTNIVFEKLPP-------MKVGGMVLKSDAKPDETYEDIGGLERQIEELNEAIVLSLTHPERFEKLVLMYGPPGTGKTLMARACASKTNATFLKLA-------PQL----QMYIGDGARLVRDAFALAKERKPIIFIDEIDAIGAKRSDSDQTGELLNQLDGFSSS-------------EEVKIIAATNRVDILDPALLDR---IEFPLPNTLGRKRILQIHARKMSVRDDVNFDELARSTEGFNGAQCKAVCVEAGMAALRKEKTEISQNDFMDGIQEVLSRKKSK................................................................................................................................................................................................................................................... 396
31 -12.800[O] COG1219 ATP-dependent protease Clp, ATPase subunit  ali follow..  20  59...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................ESSGHKLPAPKEIRTILDQYVIGQERAKKVL---VAVYNHYKRLNQR-ILMIGPTGSGKTLLAETLARLLNVPFTIADATTLTE----AGYVGEDVENIIQKLLQK-DVEKAQMGIVYIDEIDKISRKS-GEGVQQALLKLIEPPQGGRKHPQQEFLQVDTRNILFICGGAFAGGLIPEFVGRLPIATLDELDEAALMQILKNALTKQYAKLFEMEGVDLEFRPDALKAVARKLERKTGARGLRSILEGILLDTMYEIPSQQDVSKVVIDESVIDGSSQPLMIYENSEKPAKAAPEA....................................................................................................................................................................................................................... 426
32 -12.500[L] KOG0479 DNA replication licensing factor, MCM3 component  ali follow..  12  191.......................................................................................................................................................................................................................................................................................................................................................................................................TEFGHSVYKDHQTFTIQELPESAPAGQLPRAVDCVADLDL-RVLPNKQNGVSSGSFRSIIIINHIQMLSKEVIPNFEPQDVKDVLAPSICGHEETKKALLCLLGMEKILNNLRGDIVLLIGDPSVAKSQLLRYVLRMAPRAITTTGRGGLTDPDS--GERRLEAGAM----------VLADRGVVCIDEFDKMSDID-----RTAIHEVME-QGRVTISKAGIHAKLN-ARCSVLAAANPVYGMQDSLLSRFDLI------------------------------------------VLLDEHDADKDANVAEHVLKLHTYRTQGEADGTVLPMGGGVETISTINMETKKASSSIYEENTQWAGIQDTKILTMDFMRKYIHLARSVQPKLTDEATEYISEVYA-KTDQERTMPVTARQLETLIRLSTAIAKARFSKK---VEREDTEKAYNLLHFACFKEKPKA.................................................................................................................... 657
33 -12.500[R] KOG2170 ATPase of the AAA+ superfamily  ali follow..  16  58............................................................................................................................................................................................................................................................................................................................................................................................................................................................................HEPDVNFNYHTLDADIANLLFGQHLVKDVVVNSIKSHWYNENPRKPLLSFHGYTGSGKNYVAEIIANNTFRLGLRSTF--ATNDFPDKNKLEEYQVELRNRILTTVQKCQ--RSIFIFDEADKL-----PEQLLGAIKPFLDYYSTIS--------GVDFRRSIFILLSNK-GEIARITKEQYEIDHFVPFLPLQREHVRS--CVGAYLRKRG--RGDLVSNVDFVERVLNSAFSSSGCKRVDAKTDLEMAKIRPLLSSVHFDDE...................................................................................................................................................................................................................................................... 355
34 -12.400[R] COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease  ali follow..  10  15..............................................................................YVKNDDLPKTVPVFPLPGALLLPEGHLPLNIFEPRYLAMIDTALASHRL--IGMVQPALHVIEAG--IEGGPLSAVGCLGRITSF------------------------------------------------------------------SETGDGRYVISLTGVCRFRLLEVAGSEPYRSFRHAPFIADLSGEYDEEAVDRENLLRVFRAFLDANQL-------EADWESVERAGNRVLVNSLSMMSP-FGPAEKQALLEAPDLKTRAETLIAIT--EIVLAQGSGEGGTVLQ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 230
35 -12.300[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  12  1.................................................................................................................................................................................................................................................................................................................................................MDVLIEWVAIYPQIYDILENYVPSNTLQRLRLHQPWSKIDYDVWFLYASDEIRETCKVKYYGETKTYGEVFVLEN--ERISQLHRLFVSWTVSERAEHLKNLLFDAGLSNLPLVE----------------VFFNSHVPLPCSLVLTKSTQENLNRITPY----VQKRPIL-LAGPEGIGKKFLITQIAAKLGQQIIRIHLSDSTDPKMLIGTYTSPKPGQPGVLTQAVIT----GKWILFTNIEHAPSE----SVLLPLLELVIPSRGETIYAK--------GSFQMFATSSMKT---KILGQRLWQILDLTYQPDECVEVVSTLYPVLSIICPTLYSVYKDIFDLFSQRSFLATSKIYCLRDFYKFIKRVAFLYHKFMIPSDHVVISQELQDAVFKEAIDMFGAFIPSRDGFDLVVRNVAIELNIPP----------EKALQLRYSIPVFQNLEHNINIG------RCSLKKLSTIRSCSTNSYAFTSSSLGLLEQLAAG-----------------------VQTNEP---LLLVGETTGKTTTIQLLAGLLGQKVTV--QQTESSDMLGGYKPI........................................................ 516
36 -11.800[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  18  29.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEYVGQPHVREQMEIFIQAAKQRGDALDHVL-IFGPPGLGKTTLANIIANEMGVNLRTTSGPVLEKAGDLA------------AMLTNLEP----HDVLFIDEIHRLSPV------EEILYPAMEDYQLDIMIGAARSIKLDLPPFTLIGATTRAGSLTSPLRDRFGIQRLEFYQVADLEHIVSR-----------AKCLGLELTPEGAHQLAR--RSRGTPRITNRLLRRV...................................................................................................................................................................................................................................................................... 230
37 -11.800[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  14  4....................................................................................................................................................................................................................................................................................................................................................................................................................................NEFLDKAYAVLRRLDAVLPPEPGHTDWNA-----LAFRWQSAGKKGEHLPDPHTFPLVRLAGVGRQTELLVR--NTEQFIVGRPANNVLMSGARGTGKSSLVKALLHEYADKGLRL--------IEV----KSDLIGLP-YLLTLLKECPEK--IVFCDDLSFESGDET----YKALKTALDGGLSQR------------ANVLVYATSNRRHLMPEYFDENAGTTGMRGEIHEEKISLSDRF---------GLWLSFYPFDQNDYLAAVQNWLEDFGV-PYDETAQMAALQWAQT............................................................................................................................................................................................................................................................... 261
38 -11.700[T] COG2766 Putative Ser protein kinase  ali follow..  12  6.................................................................................................................................................................................................................................................................................................................................................................................................................................HYRQRYEAAKDEEFTLQDFLTICRQDRSAYANAAERLLMAIGEPNMVDTAQEPRLSRLFSEEFYGMEDAIEQIVSYLKHAAQGLEEKKQILYLLGPVGGGKSSLAERLKSLM-QRVPIYVLSANGERSPVNDHDAQIL-GYSGALCRA------NQGIMEFVEMFKAPIK------LHPLLTATQ-EGNYNGTEGISALPFN---GIILAHSNESEKNNEAFLDRVYIVKVPYCLRSEEIKIYEKLLNHSELAHAPCAPGTLET---LSRFSILSRLKEPENSSIYSKMRVYDGESLKDTDPKAKSYQEYRDYAGVDEGMNGLSTRFAFKILSRVFNFDHAEVAANPVHLFYVL---GYLIPKYAEFIGKEIQTAYLESYSEYGQNIFDRYVTYADFWIQDQEYRDPDTGQLFDRESLN-----AELEKIEKPAGISNPKDFRNEIVNFVLRARANNSGRNPNWTSYEKLRTV---------------------------IEKKMFSNTEELLPVISFNAKTSTDEQKKHDDFVDRMM-YTRKQVRLLCEWYLR 639
39 -11.400[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  15  105................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ERMRPRTLDDVVGQDHLSPSSLLRSAVESNRLPS---------IVFWGPPGTGKTSIAKSLINSSKYRFVSLSASGVKDVRDAVES------------AKRLNLEGRKRTVLFMDEVHRFNKSQQ-----DTFLPVIEDGS---------------ILFIGATTENPSFHLITPLLSRCRVLTLNPLKPNHVETLLRRAVDDSERGL----PNSVEVDDSVIEFLAN--NCDGDARVALNALEISATMATTRAGTDA---------------------------------------VVSIDDAKEALQCKHLAYDKAGEQH--NLISALHKSMRGGD---ANAAIYWLARMLEGGEEPLYIARRLIRFASEDIGLADPSALTQAVA--------YQASHFLGMPECNVI-------LAQCTAYLALAPKSIAVYRAIGAAQKVVKDSVGQNEGVPLHLRNAPTKLMKEL---PSSAAGQTYLPPSLLHHKFLEWPEGASGDFQDQEH 523
40 -11.400[O] KOG0739 AAA+-type ATPase  ali follow..  12  18.............................................................................................................................................................................................................................................................................................................................................EEDKAKNYEEALRLYQHAVEYFLHAIKYEAHSDKAKESIRAKCVQY------LDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQ-----------LMGAVVMEKPNIRW------------------NDVAGLEGAKEALKEAVILPIKFPHLFTGKILLFGPPGTGKSYLAKAVATEANNSFFSVSSSDLMSK---------WLGE---KLVKNLELARQHKPIIFIDEVDSLCGSRNENESEAA-------RIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEYIPLPEEA-------ARAQMFRLHLGSTPHNLTDANIHE--LARKTEGYS--ADISIIVRDVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSL------ATTRPTVNADDLLKVKKFSEDFGQ.......................................................................................................................................................................... 435
41 -11.200[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  24  16.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QDVVGQEHITKTLQNALVQEKF-----SHAYLFSGPRGTGKTSAAKIIAKAINRACKGITSGSIVDVMEIDAASNNGVDE-----IRDIRDHVKFAPVYIIDEVHMLTTGAFN-----ALLKTLEPPSH----------------AIFILATTEPHKIPLTIISRCQRFDFK--------RISNDALVGRMKE---LTHEGIEAEDEALVLVAR--AAEGGMRDSLSLLDQAISFADERVTVED.......................................................................................................................................................................................................................................................... 236
42 -11.200[L] KOG0482 DNA replication licensing factor, MCM7 component  ali follow..  11  222.......................................................................................................................................................................................................................................................................................................................................................................................................LQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVHRIICINKNDEISDKDAELTPEELEELAQDDFYERLATSLAPEI-----YGHLDVKKALLLLLGVDKRPDKIRGNIICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGGLT-AAVMKDPLTGEMTLEGGALVLA------DQGVCCIDEFDKMADQD-----RTAIHEVME-QQTISIAKAGIMTTLN-ARVSILAAANPAFQLPAALLSRFDLL-IQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKALDMNLMRRYINL------CKRKNPTIPDELTDYIVGAYVELRREARNQKDM----------------------------TFTSARNLLGIL-------RLSTALARLRLSDSVEKDDVAEALRLLEMSKDSLNQIHEHQKGHVPIFAIVRELAGSGKAVKISDIMDRCTTKGFKPDQVDKC-IDDYEELNVWQVNMGRTKITFM....................................................................................... 720
43 -11.200[L] KOG0480 DNA replication licensing factor, MCM6 component  ali follow..  18  401.....................................................................................................................................................................................................................................................................................................................................................................................................................................................EQDEFLQSLSQEEIDDLRAMVHSDHIYSRLTNSLAPSV-----YGHEIIKKGILLQLGVHKLTPELRGDLICIVGDPSTSKSQFLKYVCNFLPRAIYTSGKAGLKDEET--GDFTIEAGAL------------ADNGICAIDEFDKMDLSD-----QVAIHEAME-QQTISIAKAGIQATLN-ARTSILAAANPIGNMSAPIMSRFDLFFVCNESVDRHLHIVDIHRLRDDAMQPEFSTEQLQLNTESCAEIVKKYKQKNSYRITVRQLESMIR.................................................................................................................................................................................................................................................................... 706
44 -11.100[L] KOG0478 DNA replication licensing factor, MCM4 component  ali follow..  15  274......................................................................................................................................................................................................................................................................................................................................MRSLNPEDMDQLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTNCNTNRLIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLNKRLYEDEEGKDHIFPPERVELLQLLAKKPDIYDRLARAIAPSI-----YENDDIKKGILLQLGTKKKHATFRSEILLLCGDPGTSKSQMLQYVFNLVPRSQYTSGRGGLKDPET--RQLVLQTGAL----------VLADNGVCCIDEFDKMNDST-----RSVLHEVME-QQTLSIAKAGIICQLN-ARTSILAAANPAEQLPHTLLSRFDLIRLASHLVSDYIAYAREHLSPT-------------LSDEAQQRLIQAYVRKVGPRQLESLI-RLSEAHAKVRLSNQVELLDVEEAWRLHREALKQSATDPLSGKIDVGILTTGLSTAARKKRADLV........................................................................................................................................................................................................ 804
45 -11.000[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  14  27.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EQYIGQQHI---LGPGKPLRRALEAGHIHSMILWGPPGTGKTTLAEVAANYANAEVERVSASGVKEIRAAIEKARE-------------NKLSGRRTILFVDEVHRFNKSQQ-----DAFLPHIEDGT---------------VTFIGATTENPSFELNNALLSRARVYKLTSLNQQEILQALHQAI---ADTERGLGKVAAVFADNVLDRLAE--LVNGDARMSLNYLELLYDMAREDD---------------------------------------QGRKQIDLPLLAEVAGEKVSRFDNKGDIW--DLISAVHKSIRGSD---PDAALYWAARMISAGCDPLYIARRLLAIASEDVGNADPRGMQVALAAWDCFTRVGP----------------AEGERAIAQAIVYLACAPKSNAVYTAWKQALSDAHNLPEFEVPPHLRNAPTRLMKDL-EPGAYAAGECYFPPEMSGTRYYQPTPRGLE....... 425
46 -10.900[L] COG0470 ATPase involved in DNA replication  ali follow..  20  16....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VEKYRPETLDEVYGQNEVITTVRKFVDEGKL------PHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLEL-NASDDRG---DVVRNQIKDFASTRQIFSKGFKLIILDEADAMTN-----AAQNALRRVIERYT---------------KNTRFCVLANYAHKLTPALLSRCTRFRFQPLPQEAIERRIAN-----------LVHEKLKLSPNAEKALIE--LSNGDMRRVLNVLQSC...................................................................................................................................................................................................................................................................... 215
47 -10.800[L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family  ali follow..  16  169.......................................................................................................................................................................................................................................................................................................................................................................................................TEFGLSEYFDYQTVVLQEMPEKAPPGQLPRSVEVILSFDLDRAKIYFGNQQFPSRFRTVVIANNIEKAEEEEVEVEPGVEFERLSQMKNFGHDIVKRSIALLLGNEVVMRNIRGDIILLVGDPSTAKSQLLRYVLNAAQLSIATTGKGGLLDKDT--GEKRLEAGAM----------VLADRGVVCIDEFDKMSDGD-----RVAIHEVME-QQTVTIAKAGIHTTLN-ARCSVLAAANPIWRLPESLLTRFDLI-TLDKSNTDIDQLVSGHVLRMHMLTQGYEEEG-VLSREAAGLIAREYTSEQIVSITPRMLETMIR.................................................................................................................................................................................................................................................................... 548
48 -10.800[L] KOG0481 DNA replication licensing factor, MCM5 component  ali follow..  14  218.....................................................................................................................................................................................................................................................................................................................................................................DFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVP-QGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAPSI-----FGSRDIKKAITCMLGSRKRLPDRRGDIVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGGLT-ASVMKDPQTRNFVMEGGAMVLA------DGGVVCIDEFDKMREDD-----RVAIHEAME-QQTISIAKAGITTTLN-SRCSVLAAANSIFDFMPTILSRFDMIFIDIHDESRDITLAKHIINVHLSSNKSAPSEPAEISLSTFKKYIH-YCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLS--------------------------IPITVRQLEAVISLAKIRLQPFATDEHVNEALRLFQVSTLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMKV-IHTMIRRGELQHRMQRKMLYRIC...................................................................................... 733
49 -10.800[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  17  36........................................................................................................................................................................................................................................................................................................................................................................................................................................................................LPW---------VEKYRPVKLNEIVGNEDTVSRLEVFAREGNV------PNIIIAGPPGTGKTTSILCLARALKDAMLELNASNDRGIDVVRNKIKMFAQQ-------KVTLPKGRHKIIILDEADSMTD-----GAQQALRRTMEIYS---------------KTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMN-----------IEKERVPYTDDGLEAIIF--TAQGDMRQALNNLQSTF..................................................................................................................................................................................................................................................................... 240
50 -10.700[L] KOG0477 DNA replication licensing factor, MCM2 component  ali follow..  14  242.....................................................................................................................................................................................................................................................................................HVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVR--LVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPE---EVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLNHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSI-----YGHEDIKRGLALALGEPKNPGGVRGDIVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGGLRHPVS--REWTLEAGAL----------VLADRGVCLIDEFDKMNDQD-----RTSIHEAME-QQSISISKAGIVTSLQ-ARCTVIAAANPIGDLTEPIISRFDILMLARFVVGKYIIYAKERVHPK-------------LNQMDQDKVAKMYSDTGSIPITVRHIESMIR.................................................................................................................................................................................................................................................................... 772
51 -10.400[DL] KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component  ali follow..  3................................................................................................................................................................................................................................................................................................................................................................................KTFLRPKVSSTKVTDWVDPSFDDFLEC--SGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPW-----DKYKPETQHELAVHKK--IEEVETWLKAQVLERQPKQGGS--ILLITGPPGCGKTTTLKILSKEHGIQVQE-SFHMFPYQSQIAVFKEFLLRA--NKLQMLGDDLRTDKKIILVEDLPNQFYRDSHT--HEVLRKYVRIGR---------------CPLIFIISNNQRLLFPKEIQEECSISNIS-FNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKTSLELLCQ--GCSGDIRSAINSLQFSSSKGENNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFL------RALGK-----------------------------------ILYCKRASLTELDSPRLPSHLSEYERDTLLVE---PEEVVEMSHMPGDLFNL--LHQNYIDFFMEIDDIVRALSFADILSGDWNTRSLLREYST--SIATRGVMHSNKARGYAHCQGGGSSFRPLHKPQKKYRENCLAAKALFPDFCLPALCLQTQLLPYL.. 565
52 -10.400[L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)  ali follow..  13  360........................................................................................................................................................................................................................................................................................RHNIVQCLLESPDTMETLSLDYLKRLKQMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQKLETVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQIVEEIIHVAVGYAAPLTLLNNELAQ-------LDCLVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLEFIANSVDFKKEECNMFIITGPNMGGKSTYIRSVGSMVDSILGRV---GASDNI-IKG-LSTFMVEM----TSGIIRTATDKSLVIIDELGR-GTSTYEG--AWSIAEHLAKETKCFFATHFHEIT-KLAETL----------------STVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQ---------------------ARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAIQQLSTAGNNVDINVEDLTQLVTQFTKDIEQL........................................................................................................................................................................................................ 840
53 -10.200[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  10  132.............................................................................................................................................................................................................................................................................................................................EFSDYVRHISTIFVSKLLEDQGPGDNISKIFATMIDNMDQGVLVVDDESRVQNQTALKTLGVVQNNIIGKPIRFRPLTFESNFTGHMQHIVSWDDKSELIIGQLHNIQGRQLFLMAFHQSHTSFSVANAPDEP--------------------HIEQLVGEC--------RVMRQLKRLISRIAPSPSSVM-VVGESGTGKEVVARAIHKLSGRRFIAINCAAIPEESELFGYVKAFTGASTGLIQAA------NTGTLFLDEIGDMP------MLQAKLLRAIE-AREILPIGASSPIQVDI-RIISATNQNLAQFIAEDLFYRLNVIPIT---RQEDIELLVHYFLHLHTRRLGSVYPGI---APDVVEILRKHRWPGNLRELSNLMEYLVTLLPPNLLNNGTTEQSDVTEVTEAHLSLDDAGGTALEEMEKQMIREALSRHNSKKQVADELG....................................................................................................................................................................................................... 574
54 -10.200[L] COG4581 Superfamily II RNA helicase  ali follow..  12  180.................................................................................................................................................................................................................................................................................................................................................................................................TSTTDNLNDEFDPEKWDTKKVKSSNRNFVTIHELNEHLKNVNSKHSEIDDLLPDKRSIVSLPPSTLNLHKQPDYAHVVDSSAPIENFQQLVPE--FELDNFQKEAIYHLE--------MGDSVFVAAHTSAGKTVVAEAIALAQKKAIYTSPIKALSNQ-KFRDFKHKFVGILTGDV--------QVNPLLMTTEI--LRSMLYRGADLIRDVEFVDLERGVVWEEVIIMLPPHVTLILLSAT------VP----NTKEFASWVGRTKKKNIYVISTLKRPVPLEHYLWVKQNM--------FKIVDQHGRFLMDGYKSANDALKKPDKPVIAKDNKNSARGRGAARGRGVQTNMMRGRGSAKSVERRDANTWVHLIGHLHKQNLLPVIVFVFSKKRCEEYVDTLTNRDLNN-HQEKSEVHVVIEKAVARLKKEDRLLPQIGRMREMLSRGL------------------------AVH-H--GGLLPKE--QRGVLFATETFAMGVNMPAK-SVVFSGTQKHDGRDLLPGEYTQCSGRAGRRGLDVIILSRSELPDTASLRHMIMSKLISQFRLTYNMILNLL.. 739
55 -10.000[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  14  554.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GHMDEQTKLYQWV--RQTIVLGEGNSVIIVGPRGSGKSVLVDDILSRAAQESYVVRLNGTIESDEALKSEMNFSDTLT-KLLATLSHPVDLG-IFVLEEFDLFVQHSRQ----MLLYNLFDIAQSRK------------APILIIGLTTRYD-CSESLEKRVKIPMRPPSSLSEFEQILKSVL---YVSDEGGKDQIITCWNQRVDELLSD--TRSHLHKLVQHHYFASRNL.................................................................................................................................................................................................................................................................. 804
56 -9.940[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  19  42....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VEKYRPQSLDDVAAHRDIIDTIDRLTNENKL------PHLLLYGPPGTGKTSTILAVARKLYGPKYRNMI------LELNASDDRGIDVV--QQIQDFASTQSFSLLVLLDEADAMTK-----DAQFALRRVIEKYT---------------KSTRFALIGNHVNKIIPALQSRCTRFRFAPLDGVHMSQRLKH-----------IEAERLVVSDCGLAALVR--LSNGDMRKALNILQSTH..................................................................................................................................................................................................................................................................... 244
57 -9.880[R] COG0714 MoxR-like ATPases  ali follow..  21  5....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ISVLTQNLSQTIVGKDEAIRLVLVALL-------SGGHAL-LEDVPGVGKTLLAKSLARSINGKFQRVQCTPDLLPTDITGPSSREFEFLPGPAFAN---------ILLADEINRATPRT-----QAALLEVMEEKQTVDGETRLVPHPF-----FVIATQNPIEPLPEAQLDRFALSLSLGYSEAEELKMLQRQQNPEAIAVGDLESCISLEEVEALQKAVRQVKLTEDLQQYLLRLVRASRT................................................................................................................................................................................................................................................................... 233
58 -9.840[KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains  ali follow..  16  130....................................................................................................................................................................................................................................................................................................................................................................................................LTLDSLKPDAFDHLSPRSLEILAAIAAATLKMTLTFSELENQAKQTQLRLEELNQEAWSRDSVEII---------------------------GNSGPMLAMKADI---DVVAPSQFNIL-IHGETGVGKELVARTIHQRSNRKLVYVNCAAIPEESELFGHVK---GAFTGADRARMGKFALAD-TLFLDEIGELPLS------QSKILRALQNHEIQPVGQD--VQTVDV-RILAATNRDLKKEVEADLYHRLSVYPIY---RKGDLSLLAGYFVEQARRKLG--ITQLKLHGDVLSQLIQ-YPWPGNVRELEHVINRAALKAKARQRGRPVTTLKVEDLGELQGPRAAMVEPTAQDEPMLGEWIGELGLRDATDEFQR.......................................................................................................................................................................................................... 481
59 -9.710[R] COG5545 Predicted P-loop ATPase and inactivated derivatives  ali follow..  11  320..................................................................................................................................................................................................................................................................................................................................................................................................................KRLPLDRIDLKVAIDVHIDISKEQAKSVVLELALANSYSP----VVEYLQ---SVERRYPNVDVSLLDKLAERYTNDPLHAALMKRTLIAAVARAFEPGCKHDEITILQGKQKSLKSTFWEILA---GEEFF---------TDDLNGTEKDEVLKISQYWI------------LEYAEFENSYKKK-----DVSQLKAFLSRKKDSMRRPYGTDIEDFPRSILVGTTNLDE-----LYDRFWVIKVLFKKIPAAVAAYRNRLTEVEDEWLDAANKQYQSTDTWEEAVMAWAELQKEVSVGENRVAAILRSHGWTRGDRKVEQEVERGVEQEVERGVEQEVEQPQALVTTDLEPECSTCSTNSPQTFPNFDSNNETAQWIAPQTAAPFVTPQETTPTEANEKSLEGQGVEQPVDEPQTQSPQVIEECSTPCFTSGSSLELSFEQKLMGNVALIRESIADQCWGLIA---TLTEEWTSEFKSAVWKELTPQERQAVKQLKAL..................................................................... 835
60 -9.380[L] COG1193 Mismatch repair ATPase (MutS family)  ali follow..  13  92........................................................................................................................................................................................................................................................................................LKRVLLASRELQNFYTNLENVSLEELALWFEKLHDFPQLQ------------GNLQAFNDAGFIENFASEELARIRRKIH--DSESQVRDVLQDLLKQKAQ--LLTEGIVASRNG-GVVHDISASGNTVYIEPREVVKLSEEIASLRADERYEMLRI------QEISERVRPHAAEIANDAWIIGHLDLIRAKQLSENQEIQLLHVCHPLVKNAVANDVYFGQDLTAIVITGPNTGGKTIMLKTLGKGSRVGIFEEIFADIGDEQSIEQSLSTFSSHM--NIVDILGKVN-QHSLLLLDELGA--------DPAMAILEDLRLRQIKTMTTHYPELKAYGIETAFVQNAS-MEFDTATLRPTYRFQGVPG--RSNAFEIAKRLGLSEVIVGDALEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKAREQAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAKKKRAPKVGDDIVVLSYGQRGTLTSQL-----KDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPVKKKQVNVVKRTSGRGPQARLDLR-------------GKRYEEAMLDTFIDQALLNNMAQVDIIHGIGT----GVIREGV................................................. 746
61 -9.310[KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  13  196............................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLRHNTHDATRNALRTRYVLGDMLGQSPQMEQVRQTILLYARSSAAVL-IEGETGTGKELAAQAIQGKKSHPFVAVNCGAIAEEAELFGYEEAFTGSRRGGRAGLFEIA--HGGTLFLDEIGEMPLP------QTRLLRVLE-EKEVTRVGGHQPVPVDV-RVISATHCNLEEDMRRDLFYRLSILRLQ---RVADILPLAESFLKVSLAALSFSAALRQGLQASET-VLVHYDWPGNIRELRNMMER-----LALFLSVEPTPDLTPQFLQLLLPELARESAKIPAPRLLTPQQALEKFNGDKTAAANYLGISR.................................................................................................................................................................................................... 519
62 -9.280[DL] KOG2035 Replication factor C, subunit RFC3  ali follow..  14  20.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DYHIEQANHLKFLSADCMPHLLFCGPSGAGKKTRIKCLLRELGVGVEKTQL----TPSDVGIYDRVVV-----DLVKEMAQTSQIESVVVLCEADSLTR-----DAQHGLRRTMEKYA---------------NNCKIVLSCESLSRIIEPLQSRCIIINVPAPTDEDVTKVLRK-----------IERESFLLPENVLQKIVE--KSEGNLRRAILMTEAL...................................................................................................................................................................................................................................................................... 235
63 -9.250[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  15  336......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................APVIAALQAKAAKLARTRLPIL-IQGETGTGKEHLARAIHEGSGLEFVAINCAAIPEESELFGYLPAFTGARKGLIEQA------DGGTLFLDEIGDM-------ALQSRLLRVLA-EGEVLPVGGTAPRKVRI-RIVSASHRPLQTLVSEDLYYRLNAATLTLPALRDRPDFDW--VLEQLLKRHGDGELIL---SPAALSALKAHDWPGNIRELDNVIGVAAALAENGVVELGDLPDQLLANADTVGGNEASATLSLTTACNWNISEAARRLGLDRSTVHRQI........................................................................................................................................................................................................ 617
64 -9.200[R] COG4889 Predicted helicase  ali follow..  12  180..........................................................................................................................................................................................................................................................................................................................................QQTAIEKAIEGFQTHDRGKLIMACGTGKT----TALRLSEEVARLNGNKARILFLVPSISLLSQTLKEWTAQSDSKVSKAAEDIAAYDLEVPVSTDGALIAEKLEHRKRAAGLTVVFSTYQSLPAVHAAQEAGAEPFDL-----ICDEAH-------------------------------------RTT-GITLAGEDPSNFTR-----IHDASYIKAAKRLYMTATP-RLFDDSVKGKAADEVSSMDDEAIYGPEFHRLGFGEAV--------EKGLLTDY--------KVVVMTVDE--QVAASALTVLGSTPGEELTLDMTSAIIGAWNGLAKRSGKEQDTKTGFSSSDAAMERAVAFARDIKTSQQIAESFPRVVNAYTTELEVKNDDVDEHNLNLSVACQHVDGSMNALERNSR----------------LTWLKAPT--------QSMETKILTNARCLSEGVDVPALDSVIF-----FNPRNSMVDVVQSVGRVMRKSPGKNYGYI............................................................................................................................... 609
65 -9.180[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  15  104..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................PRDEEQMRAVKEALHVSK-CREDEQIRIFEFV--KGCIDQQKAGSLYICGCPGTGKSLSMEKVVQQVGDWSTQAGLPPVD--LSVNCTSLSKTTDIFSKILGEIKPGKNAN-LIIADEMDYLITKD-----RGVLYDLFMLTTLPF------------SRCILIGVANAID-LADRFLPKLMVITFRAYSKDQILRILQERL----------VLSYVAFQPKALELCARKVAAASG--DMRKALC-VCRS-ALEILEIETRGSTGPESQGPTPDDSVVRMDHMAAALSKTFKSPVVETIQSLPQHQQII........................................................................................................................................................................................................ 414
66 -9.150[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  12  58...................................................................................................................................................................................................................................................................................................................................IRRISGVTDVRTVPWMPSEREHLALSALLEALPEPVLSLDMKSKVENPASCQLFAQSQERMRHHTAAQLING------------FNFQRWLDGNPQSSHNEHVVINGQNFLMEITPVHLQNENDEYVLTGAVVM------RSTIRMGQQLQNLSQDLSAFSQISAKMKHVVEQARKLAMLSAPLL-ITGDTGTGKDLFAYACHQASPRSYLALNCASIPEESELFGHAP---EGKKGFFEQA------NGGSVLLDEIGEMSPR------QAKLLRFLNDGTFRRVGED--EIHVDV-RVICATQKNLVELVQEDLYYRLNVLTLN---CPQDIMPLTELFVARFADEQGVPRPKL---SADLSTVLTRYGWPGNVRQLKNAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQLYR-STRKLAKRLGVSH.................................................................................................................................................................................................... 494
67 -9.140[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  15  176.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QQTLDFLKSGIATRNPHFNRMIE--QIEKVAIKSRAPIL-LNGPTGAGKSFLARRILELKQARFVEVNCATLRGMSTLFGHVK---GAFTGARESREGLLRSAN-MLFLDEIGELG------DEQAMLLKAIE-EKTFYPFGSDRQVSSDF-QLIAGTVRDLRQLVAEDLYARINLWTFT---RQEDIEPNLDYEVERHASLTGDSVRFNTEARRAWLAFSPQATWRGNFRELSASVTRMA..................................................................................................................................................................................................................................................................... 423

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24