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Query: [O] KOG2016 NEDD8-activating complex, APP-BP1/UBA5 component, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQLLast
1 -143.000[O] KOG2016 NEDD8-activating complex, APP-BP1/UBA5 component  ali  100  1MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL 534
2 -69.200[O] KOG2014 SMT3/SUMO-activating complex, AOS1/RAD31 component  ali follow..  22  1MDGELTEQETALYDRQIRVWGANAQRRLTKAHILVSGIKGTVAEFCKNIVLAGVGSVTLMDDRLANMEALNANFLIPPDESGKTVAEICSDSLKDFNPMVRVSVEKGDLSML---GTDFFEQFDVVVIGYGSRATKKYVNEKCRKLKKRFYTVDCRDSCGEIFVDLQDYKYTKLEEMVE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CELNFPSFQEAISVPWKPIPRRTAKLYFAMRVIEVFEESEGRKHGECS---LLDLARVLEIKKQLCEANSVSESHIPDILLERLITGTTEFPPVCAIVGGILAQ-VIKAVSGKGDPLKNFFYYDGEDGKGVMEDI 313
3 -56.700[O] KOG2013 SMT3/SUMO-activating complex, catalytic component UBA2  ali follow..  12  2.......PTLMQLSNDKPLTFVEALRNFKSAKVLLVGAGGIGCELLKNLLMSGVKEVHIIDLDTIDLSNLNRQFLFRKKHVKQPKAIVAAKTASSFNPNVKLEAYHANIKE--RFNVAWFRQFDLVFNALDNLDARRHVNKQCLLASVPLIESGTTGFLGQVQVIIHGKTECYDC---------NPKEPPKTYPVCTIRSTPSQPIHCVVWAKSYFF-PQLFSNDQESDGIIDNVSANEMERREIAELARETTELNELRSSIGQSDNGFEKIFTKMFTKDIVRLRE------------------------------------------VPDAWTYRSPPKELS------------------------------------------------------YSELLENAEKATSPWLNEQNVWNVAESFAVLRDSIRRLALRSKSSDLSFDKDDKDTLDFVAAAANLRAHVFGIQ-QLSEFDIKQMAGNIIPAIATTNAVIAGLCITQAIKVLQGDLNDLKNIYLAKRPTRV...... 417
4 -45.600[O] KOG2015 NEDD8-activating complex, catalytic component UBA3  ali follow..  22  14.SIRRLTDRDSAYKVPWFVPGPENFEALQNTKILVIGAGGLGCELLKNLALSGFRTIEVIDMDTIDVSNLNRQFLFRESDVGKSKAEVAAAFVQQRVVGCQNYFNFISIFRIEDKGQEFYRKFSIIICGLDSIPARRWINGMLCNTIIPMIDGGTEGFKGNARVIYPKFTACIDCTLDLYPP................................................................................................................................................................................................................................................................................................................................................................ 211
5 -40.200[H] KOG2017 Molybdopterin synthase sulfurylase  ali follow..  15  60LEHGLSPDQIYRYSRQLLLFAVEGQSNLLKSSVLVIGAGGLGSPALLYLAACGVGQLGIIDHDVVELNNMHRQIIHTEAFIGHPKVKSAAAACRSINSTIKVDEYVEALRT--SNALEILSQYDIIVDATDNPPSRYMISDCCVLLGKPLVSGAALGMEGQLTVYNHNGGPCYRC-------LFPTPPPTSACQRCSDSGVLGVVPGVIGCLQALETIKLASLVGEPLSERML............................................................................................................................................................................................................................................................................................................. 285
6 -38.900[H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1  ali follow..  20  6LDTPASDSYNQRFGGTRRLYGYDEVDILRAAHVCVIGIGGVGSWAVEALARTGIGELTLIDMDDVCVTNINRQIHAMTGTIGKSKIEVMAERVKLINPECKVNLVDDFITP--DNQHLYLKSFDYVLDAIDSLKAKASLLAYCRSNKIKVITVGGAGGQTDPTQI................................................................................................................................................................................................................................................................................................................................................................................. 169
7 -34.900[H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2  ali follow..  15  113.PNRGLGVSPPALQRQALAFGEALNQDLSMLRVGVIGCGGTGSAIAMLLPKMGIRNIALFDKDIVEDTNLNRLHGARQPDAMSPKVEVVAKSLVELGLGVQVRTYQAWIGE--ADCRDPLKACDVIFCCTDDHTGRLMLNRFAYYYATPVFDMGLQALDGRVTVLVPA.............................................................................................................................................................................................................................................................................................................................................................................. 291
8 -32.900[O] KOG2018 Predicted dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis  ali follow..  14  98.VPYDENLIREQLARNYAFFGEDGMERLRNSFVIVVGCGGVGSWVINMLARSGVQKIRIVDFDQVSLSSLNRHSIATLQDVGTPKTLAIKKAIKKFAPWIEVDARNALFNP--DSADDLLSNPDFVIDAIDNIQTKVDLLSYCYNHKLPVIASTGSACKSDPTRV................................................................................................................................................................................................................................................................................................................................................................................. 260
9 -32.700[R] COG4015 Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family  ali follow..  15  2.............AVILLEISELEGKKAPRGEVTLVGAGRLGLRTALNLMQGGPERINVIDGQRVSADDLIFRLMG--ATPGEYKVKFI-ESLATPGFSRTVRGIPEYIDR--DNLHLLRGDVCVEIAGGDTLPVTAEIIKYAQKRGSATISTMGVFGIGEEEVN................................................................................................................................................................................................................................................................................................................................................................................. 152
10 -29.900[H] KOG2337 Ubiquitin activating E1 enzyme-like protein  ali follow..  10  305.PFVLSESASTLNLSLMRLVPQLDLDRIQNSKCLLLGAGTLGCGVARNLLSWGVRHVTFVDYSTVSYSNPVRQSLFTFEDCKLPKAECAAQRLKEIYPNMFSTGYNEKTMHDYETLENLISTHDAIFLLTDTRESRWLPTVISTAMDKLLINSALGFDSWLVMRH--GSVLQKENRLGCYFCNDIFAPSNSLVDRTQTCTVTRSGCANIATAIAVELFVSLLQHPNGHAAPVLNEDQTVLGELPHQIR.............................................................................................................................................................................................................................................................................................. 570
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205