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Query: [F] KOG2070 Guanine nucleotide exchange factor, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQNLast
1 -132.000[F] KOG2070 Guanine nucleotide exchange factor  ali  100  1MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQN 782
2 -74.700[T] KOG2996 Rho guanine nucleotide exchange factor VAV3  ali follow..  20  1MEPWKQCAQWLIHCKVLPTNHRVTSAQVFDLAQTLRDGVLLCQLLNNLRAHSIKEINLRPQSQFLCLKNIRTFLTACCETFKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEV------------------------------------------------------------------YEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR--FLTAAEFDSVFINIPELVKLHRNLMQEIHDSIV-NKNDQNLYQVFINYKERLV-IYGQYCSGVESAISSLDYISKSKEDV-ECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTD-PTEKANLKLALDAMKDLAQYVNEVKRDNETEIKQFQLSIENLNQP-VLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCK--RKGDNYEMKEIIDLQQYKIANNPENKKWSYGFYLHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVT.......................................................................................................................................................................................................... 525
3 -66.600[R] KOG3518 Putative guanine nucleotide exchange factor  ali follow..  19  515............................................................................................................................................................................................................................MATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQILFANIEEIYEFNSMLLQRLINTGRDP---GRIARCFIDLRDGFD-VYTTYCTSYPEAISLLTKLLQHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC-----DVKEVVEAHVIMRQVAHNIDQVKRKQEQRVKELSGILDGWLGPELTVLGELRQEGLLMEQ-----HNKQRLVLLFATMLIITKQKED-GRLQFKTYISQNNLMLSEHLPGEPTSFYVIPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVY................................................................................................................................................................................................................... 854
4 -60.500[T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac GTPases  ali follow..  14  200.........................................................................................................................................................................................................................SLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDGKDKIVFGNIHQIYDWHKDFLAELEKCIQEQ---DRLAQLFIKHERKLH-IYVWYCQNKPRSEYIVAEYDA----YFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMN---------LGRLQGFEG-TLTAQGKLLQQDTFYVIELDAGRTKERRVFLFEQIVIFSELLRLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRET-SERVVLQAANADIQQAWVQDINQVLETQRQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASK................................................................................................................................................ 616
5 -55.500[T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3  ali follow..  17  1............................................MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDADKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEGSFPAEMVNKIFSNISSINAFHSKFLPELEKRMQEWETTPRIGDILQKLAPFLK-MYGEYVKGFDNAMELVKNMTERIPQF-EIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENKLLEIYEMLGE--EEDIVNPSELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSGSKFTVRTRVGIDGMKIVETQNEE-YPHTFQVSGK-ERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEV.......................................................................................................................................................................................................... 544
6 -48.400[T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases  ali follow..  16  306............................................................................................................................ENNFLYTKRRANTSDSFDSVLSDSSTTPTISSSVQVNSLAFITSSLSAITKEPEAPETEYNPHGVFTLLT----ECYSSTCSRNRLCYSISCPRRLEQQARLHLKVQPVLSGGSTSVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVIPENNIRCVFHNIMQIHAVNSRLSNALNRTQTLQPVVNTIGDLFLDYVPKFE-PFIKYGANQAIAKFEFEREKSTNRNF-EVERLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDKDNPDTENIPRVIEMIREFLTKLNYETGKTENRLSLLNEQLSCSPADTLFDPSRLIFKGVVKLKASNGDTENDIHMFLLDNFLLLCKIKIQMKRRVHLRPLPLELLSISYIEDSPSRGLQLVFIGARGFSISLYLNTLIARDQWKQHIEKQQDIIRKRHLVFESRGICCQSWFTG........................................................................................................................................................................................................... 825
7 -42.700[T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)  ali follow..  9  327.....................................................................................................................................................................................................................MRDCSVEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEMVETEKNYLSLLKLVVKFKECEISHNEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNE-DKNLDFAQVWIDAKEEMKKAYPQYINSYDTIKRLFDKQDRENSKF-AKESNPEFHRLKLTDLMVKPVQRLPSVILLLKEMAKKSDSKLKN--NAEEAAKAIDEVLKTANKTREKNDNFISHLSTDIENVPPILVAANRMFIRELVVS-TSPGLQQFAKMKLFLFHDVLIITKIRSEKRPYRYIDQIQLNTMRSA---------FRIRAPDEIAKCLELQQQNGSTKPNVFVWCLIHRDEQGGDIDTVFESNDDEEVRDFLDDIHVKILSDCGRFFYSSDPSDMNEINDAMVSDMTTRYFRNLCGAKPQYGHGSQMNITEWSHNESFMPPPQSQSRMRRAFSNAQLTLATTLGFGRNQSRNNLGQINENTTFLQSPRVSCDPAALANMTSVGGLPGCQSESESTPKRGIRSRLTSTTFLGGRHNILGRNTSMRRQATGFAHSEKELPRSKTSSYRVTD...... 923
8 -33.000[T] KOG4269 Rac GTPase-activating protein BCR/ABR  ali follow..  15  54....................................................................................................................................................................................................................PTMSPQLSARSQGRGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLL-PMKPLKSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQL-GVYKAFVDNYKVALETAEKCSQSNNQFQKKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAV------------TTPKGETRQLVKDGFLVEVSESSR-KLRHVFLFTDVLLCAKLKKTSAQYDCKWYIPLADLVFPSPEESEA----------SPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFE............................................................................................................................................................................................................ 413
9 -11.200[U] KOG2215 Exocyst complex subunit  ali follow..  10  1.................................................................................................................................................................................................................................................................MLSNEDGLFQTDAFSPSDYIRDRLK-GVKIGDETRKLRHLRSEMGALNHASQETLK-----------------------NNVFRNY------------------QQFID---------------ASKEISHLEREIYQLTHSLIEQKQVIENLIMMTGDDKSSIHTVSSHSTTTSTTN-PIQILMQKMEGIGG-NNMSTSEKVILYGEQFDVETKKPVQKCMLILLSHRLIIGNINAA-GKYVMESTLSLNSVAPVNVKDRESAGKVLKLLIFP-ESRCYLCESARIRTLWFDELEQAKREILHKGSLVRQATIRGKRQTV............................................................................................................................................................................................................ 268
10 -10.500[T] KOG0521 Putative GTPase activating proteins (GAPs)  ali follow..  10  19.......................................................................................................................................................................................................................................QFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFLWDLQQHFLDNKNAH-NALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILS------ASKSCFQHTALDYVITLAQARKVPS-ILSTLLDYYQA-HQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNRYCDSNTNSNKIEGYLFKKKSKGFKTWCRRWFYLSDQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDR---RFCFEV--SPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTNAPNNS........................................................................................................................................................................................................... 375
11 -9.130[T] KOG0197 Tyrosine kinases  ali follow..  12  29.....................................................................................................................................SAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKA--SFLIRESETNKGAFSLSVKD-IKHYKIRCLDEGGYYISP-RITFPSLQALVQHYSKKGDGLCQRLTLPCVRRKLGS-------QFGEVWGYYKNNMKVAIKTLKEGTMSPEAFLGEKALQHERLVRLYAVVTKPIYIVTEY-MARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAK-------WTAPEAIHFGVFTIKADVWSFYGRVPYPGMSNPEVIRNLERGYRM---PELYRGVIAECSRPEERPTF-EFLQSVLEDFYTATERQYELQ.................................................................................................................................................................................................................... 504
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.