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Query: [O] KOG2177 Predicted E3 ubiquitin ligase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNSGILQVFQRELTCPICMNYFLDPVTIDCGHSFCRPCFYLNWQDMAVVAQCSKCKETTWQRNLNTDICLKNMASIARKASLRQFLSSEEQICGMHRETKKMFCEVDKSLLCLLYSNSQEHRNHRHCPIEWAAEERRSLWEKACENLRNLNMETTRTRCWKSFGDILQRYESLLLQVSEPVNPDFSAGPIIGLMDRLKRFRVDFTLQPERDNSHIFLYGDLRSMNIGCDPQDDPDITAKSECFLVWGAQTFTSGKYYWEVHVGDSWNWAFGVCNNYWKEKRQNDKIDGEEGLFLLECVKEDTHCSLFTTSPLVVQYVPRPTSTVGLFLDCEGEDNEANEIFGGKNSRKPKKAKREEQENQPVNSKSESEQWHMPQCVSSELSAQPITGLMDRFHDLQAGQMERDGPDLAKWVLHEPSGSTLPFNKDLGCDDSSRVLHHNHGPPGSSRQVPAKSTGVETKDQAHRNRDPGSFQGGVLTARYRIHRITHHESQRDLRQSLGMRLVLADCRTLYSQKQVENIVTLNSHAPTSDQECPVLEGSARTGSFVFSSATSTHMEQICFHMAKMRSAGPVARHIAAEATWTCLMGQRERLPTGKPRLDKEPLWPSTSTINFYIIAPTLALSFALLFASFNLYALITMQEILLast
1 -190.000[O] KOG2177 Predicted E3 ubiquitin ligase  ali  100  1MNSGILQVFQRELTCPICMNYFLDPVTIDCGHSFCRPCFYLNWQDMAVVAQCSKCKETTWQRNLNTDICLKNMASIARKASLRQFLSSEEQICGMHRETKKMFCEVDKSLLCLLYSNSQEHRNHRHCPIEWAAEERRSLWEKACENLRNLNMETTRTRCWKSFGDILQRYESLLLQVSEPVNPDFSAGPIIGLMDRLKRFRVDFTLQPERDNSHIFLYGDLRSMNIGCDPQDDPDITAKSECFLVWGAQTFTSGKYYWEVHVGDSWNWAFGVCNNYWKEKRQNDKIDGEEGLFLLECVKEDTHCSLFTTSPLVVQYVPRPTSTVGLFLDCEGEDNEANEIFGGKNSRKPKKAKREEQENQPVNSKSESEQWHMPQCVSSELSAQPITGLMDRFHDLQAGQMERDGPDLAKWVLHEPSGSTLPFNKDLGCDDSSRVLHHNHGPPGSSRQVPAKSTGVETKDQAHRNRDPGSFQGGVLTARYRIHRITHHESQRDLRQSLGMRLVLADCRTLYSQKQVENIVTLNSHAPTSDQECPVLEGSARTGSFVFSSATSTHMEQICFHMAKMRSAGPVARHIAAEATWTCLMGQRERLPTGKPRLDKEPLWPSTSTINFYIIAPTLALSFALLFASFNLYALITMQEIL 642
2 -41.200[O] KOG4185 Predicted E3 ubiquitin ligase  ali follow..  11  2..........SFIDCEICDEEFSTPRILRCGHTTCHGCAEKLLRNST--ILCPFCREATNVKDLQKNFALLQAVEHTKTKTEEKDSIDAPPKCASHQYNLAEFCRSSDKLMCRTCEEFGAHAGHKKGLLQSEAAKLRQFLSGKLSRSEELASQIETNIEKIGRAQLTNIDDGEVFQEKKDSIVSYYTTLRMTLDALENEALEKLAIQVSKVSRMNSLPWEFEEASVGDENAALININDSLTNYHICTCKFMLISGHIIITSYKSARAYHRGAIISDSEMYRIFLIFSCLVGHLEANCIAK-------APMKETIISERSMPLAVKCSKECLNPPVEKPE--DSRVTGYIQKNFIYTEGCSIGCKRG----------------------------------------------------------------------------------------------------------------------------------------------------------------PGCGALTFQVSFCLVLGTI---------CQRVLFRL-DLR------KKLAS--------G--ETVPIGPPQLP--PLF----TQNF--CEDT--------FWS-NITQFICSYE.. 549
3 -27.400[S] KOG4367 Predicted Zn-finger protein  ali follow..  14  1.....MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTNSCITCPQCHRSLI-RGFPKNRVLEGVIDRYQQSVSRRLSPRKVSTCTDHEENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGSYDDRVVLGKTGFSKGIHYWELTVDRYDDPAFGVARMDVMKD---VMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKNLTFFINDEQQGPIAFDNVE---GLFFPAVSLNRNVQVTLHTGLPV....................................................................................................................................................................................................................................................................... 699
4 -22.200[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  9  11.QLQQAINSTIDKECAVCYSEMILPTTIPCGHKFCFICLKGVSVSNNG--DCPICRGPIDSQIFKKPLQAVDLKMDIPGTPSAAAPDPVVKQEVDDEDVKPDVKKLQEELKKQQAAAAAQKMFWLYRGRHQGWWRFDPRIEKEIEEAFTHQMPMTEVTICGNPYIVDFSQMCQYPKNQSNYSRNVKRVNSTDFDSLNVKGMSGVFVATTSPPA............................................................................................................................................................................................................................................................................................................................................................................................................................................. 221
5 -21.100[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  15  15.SIPSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQP---NCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSK...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 166
6 -21.100[L] KOG0287 Postreplication repair protein RAD18  ali follow..  15  15.SIPSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQP---NCPLCLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELISESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSSKPSK...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 166
7 -21.100[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  8  1MDDE--GARKVDEKCPLCQANMKLLINPECYHKMCESCVDRIFTTGPAQCPTPGCNKILRKAKFREQTFEDAQIE--REVDVRKRISRIFNKGQQEFDSLQAYNDYLEEVEILTFNLIYKIDVEETEKVKQYEKQNRDSIAANSARAAAEARILAQNEILLKRQKQEAREAAIREHQKEKERREQVEQQIIFDLATSGKDPNKIIQLSDSLKKQ............................................................................................................................................................................................................................................................................................................................................................................................................................................ 217
8 -18.200[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  10  241.MVKNEKKEDIPFVCLICKKDYRSPIATTCGHHFCEQCAITRYRKTPT---CIQCGADT-KGLFSVDKNFDRLLKNRKSKNDEAVKQKVGGFESNNSATTEVSERKDREASFQGFADTLAKPNTSAQQKMPSLGDNSNTIISKYFIREITESNIVHFKRLVR................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 397
9 -15.300[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  30  261.........EELYKCPICMDSVSEPVSTKCGHVFCRECIETAIRATHK---CPICNKKLTARQFFR................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 316
10 -14.700[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  20  264.KDSDEDENALPFACFICREPFVDPVVTKCKHYFCEHCALKHHTKNKK---CFVCNQPT-MGIFNAAHEIKKRMAEERSKAEQGLRRLWPV....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 349
11 -13.100[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  20  356..........RDFECAICSNVAYKPVRLGCSHVFCLHCLIILQKQKVD--FCPLCRAKEVMDSRNIDHALMNFMKTY----FPREIKEKFEENENDTFTPSSISVVSGQNNCVIM............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 456
12 -13.000[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  18  103.MEKTSSVPGGFFDCNICLEKAEDPILTCCGHLFCWGCFYQLPLIYLNIKECPVCDGEVTDAEVIPIYGNGDDCDGTKPKLEDCGISLPPRPNAKRVESVR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 202
13 -13.000[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  11  1MMIKVKETMRACLSCSICDNILRDA------TTISEKCIYEKITEDEIE-TCPVCNIDLGSEKLRPDHNLQDLRAKIFALKRRKVKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFTQNKRQSKKSCKESISNKENKDGDEPWDSKMDWKPLNFLVEVANGTKPLKSSASQGSGSKSEHANVSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQFQGSKTKTKNKKRKCKREDDKSNNGDPTTSETVTPKRMRTTQRKRSATTLGDSRNLPQPDESSAKQERRNGPVWFSLVAQEGGTSLPQIPA-----NFL-GNTTVSFIQKYLMRKLDLESENEIGEAVIPTLT---LYNLVDLWLQKSSNHQRFAALVGSSAKDFTMV-----LVYARKLPECNM.......... 414
14 -12.500[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  12  2.............ECKKCKSNELVMMINECGHPLCKNCVDNIFALNSGN--CHVCNRVLRKNNFREQIYEDPLIDKETFLRRKLRKIYNLKQDDENLREFGDYQERKFFEPLKFPVKIKISNFRRFKNFKNFFYEFSIRYSNSPSFSWSNPEFSAQNSKIAPSNSKFQFFRFETVVYNLVFETNVNETNAEIQAFEEKHKEQIDRNKRRLDDDQKWIEDQLREERAMKARMTDHMEMDAKEQEAASAVTDTRK-------------------------------------------------------------------------IMD----ELRDSNVAAEVILDRERKKQIEKE------------------------------------------------------------------------------------LEEKEEQEKRKRRNKEMLQTRKRAAENMSFNTVIRVAGRAYVHQVGHENSEEIEKMQLFHSKFQIFKSIFRFSPLE----LVINGPP-----PNVSEIEALG-----------------YLAHIRQPTA--EYIAG--------GYTPMLGCSR----------------------------ALFEARIDLFSF....... 403
15 -12.100[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  9  277.RKGHFKDLPDDLKCPLTGGLLRQPVKTSCNIDFSKEALENALVESD--FVCPNCETRILLDSLVPDQDKEKEVETFKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 441
16 -11.100[R] KOG3953 SOCS box protein SSB-1, contains SPRY domain  ali follow..  10  1...........................................................................................................................................MSDVEVDPQQAHPHPIAAIAPRRRRPTGRRGGVTGGLSSGSLDASSSTSPPPRFCPLPNGVEDNWTWSKRHRSKEVVLRGP--------NSRTVHFHPNWSKTAGVQGKRSLNNGRHYWELHVSQRTSIMFGIGTKSARLHANRNMLGENEHGWGLSHKGVLWHEG--VALLYTKRFRENQPTQIGVLFDGIEGTLTFYKDGKCLGV-AFRGLDQIDEPLYPIVCSTAAKT................................................................................................................................................................................................................................................................................ 226
17 -10.900[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  7  92.NRRMSNGNKVTLRDCLVLSVWKFGANTKSGILDSIVFPVD-TDIPASTSGFSSDEVEGSLRDVRK--IYASRVAAVDDEAHKRILFLEAK------------------------LRSIEQKTASWSNKEVQWKITEAELRLEVTKLKKKIANMESTTKGSQSQSNVASQEKYIPAHNIYQEHHGQSPSCSFRHQGDLLINGGRIFDIDGGRQILLYARRLSGVGGTFVLTQMSLHSPCEIDDILLPRKDLHLSPHNNGLAVFGSLGKKLSVI--SLESHNTVLSYDLPAAPWSCSWDLKSSHH---------------------IYAGLQNGMVLIFDMRQTTGPFASMTGLTTNPVHTVHHLSGNSTPTSDVRTLLSASSIGLCQWNISGSEGSPSLVSETGNPGVCISSSYCPRSNHIVASYRPRVGSSDDTVPTQPSLTQTGVSNSNSNGVDGFHVCHKRRGVDSYYQKLSSTQAIVDPIRLPRTAIIDFGGERKQLFASCDESTLQDPSTFTISQRLPLSS-----HLPLQDVKHVNGSDLLGLLTDDRL-----QILRNES--P........................................................................ 614
18 -10.900[T] KOG0297 TNF receptor-associated factor  ali follow..  9  1MAAASGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQ--NCAACVHEGIYEEGISILESSSAFPDNA----------------ARREVESLPAVCPSD--CTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVSDFARKRQEAVAGR-IFSPATSRYGYKMCLRIYLNGDGTGRGTHLSL---FFVVMGPNDAL------LR----WPFNQKVTLMLLRPVNDMNIASGCPLF-----CPVSKM. 478
19 -10.800[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  19  835..QEEVKNCKNILKCGVCFDRPKEVVIVKCYHLFCQQCIQRSLEIRHR--KCPGCGTAFGQNDVRL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 896
20 -10.700[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  12  2..........DWIQCNHCGIKPNQTYLTACGHVFCQNCTKAAFNS-----QCYLCKKPLKVDEINKNL---------------------RPDLMELFKDPRQLASDLVNELKQVVAFQAKQREIYVKCKNAEAKKDTERFAEARSKHVEKTQEIEKRKKAFLEDNVKLKNAKEEKNQLMA.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 147
21 -10.300[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  16  170LSYNDDVLTKDAGECVICLEELLDTIALPCLCIYHKSCIDS-WFEVNR--SCPEHP.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 225
22 -10.000[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  20  273.KNQLPFIPEASRKCILCLMNMSDPSCAPCGHLFCWSCLMSWCKERPE---CPLCRQHCQPQEI.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 332
23 -9.500[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  22  640.ECPAVEKLATDELCKICMDAPIECVFLECGH--CTSC-------GKVLNECPICRQY-----------IVRVVRFFRA................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 700
24 -9.080[R] KOG3002 Zn finger protein  ali follow..  19  44.KFHSSNGVYELLECPVCTNLMYPPI-HQCGHTLCSSCKLRVQNT------CPTCRYELGNIR---CLALEKVAESLEVPCRYQNLGCQDIFPYYSKLKHEQHCR--RSYSC.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 145
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 4 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.