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Query: [C] KOG2189 Vacuolar H+-ATPase V0 sector, subunit a, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGDYVTPGEEPPQPGIYRSEQMCLAQLYLQSDASYQCVAELGELGLVQFRDLNPDVSSFQRKYVNEVRRCDEMERKLRYLEREIKKDQIPMLDTGENPDAPLPREMIDLEATFEKLENELREVNKNEETLKKNFSELTELKHILRKTQTFFEEHEDMIASSAESSGIGEVLSADEEELSGRFSDAMSPLKLQLRFVAGVIQRERLPAFERLLWRACRGNVFLRTSEIDDVLNDTVTGDPVNKCVFIIFFQGDHLKTKVKKICEGFRATLYPCPDTPQERREMSIGVMTRIEDLKTVLGQTQDHRHRVLVAASKNVRMWLTKVRKIKSIYHTLNLFNIDVTQKCLIAEVWCPIAELDRIKMALKRGTDESGSQVPSILNRMETNEAPPTYNKTNKFTKGFQNIVDAYGIATYREINPAPYTMISFPFLFAVMFGDMGHGAIMLLAALFFILKEKQLEAARIKDEIFQTFFGGRYVIFLMGAFSIYTGFMYNDVFSKSINTFGSSWQNTIPESVIDYYLDDEKRSESQLILPPETAFDGNPYPIGVDPVWNLAEGNKLSFLNSMKMKMSVLFGIAQMTFGVLLSYQNFIYFKSDLDIKYMFIPQMIFLSSIFIYLCIQILSKWLFFGAVGGTVLGYKYPGSNCAPSLLIGLINMFMMKSRNAGFVDDSGETYPQCYLSTWYPGQSFFETIFVLVAIACVPVMLFGKPYFLWKEEKERREGGHRQLATIEIILVVLALVQVPIMLFAKPYFLYRRDKQQSRYSTLTAESNQHQSVRADINQDDAEVVHAPEQTPKPSGHGHGHGDGPLEMGDVMVYQAIHTIEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVFRNAFVLDGYTGAIATYILFFIFGSLSVFILVLMEGLSAFLHALRLHWVEFQSKFYGGLGYEFAPFSFEKILAEEREAEENLLast
1 -229.000[C] KOG2189 Vacuolar H+-ATPase V0 sector, subunit a  ali  100  1MGDYVTPGEEPPQPGIYRSEQMCLAQLYLQSDASYQCVAELGELGLVQFRDLNPDVSSFQRKYVNEVRRCDEMERKLRYLEREIKKDQIPMLDTGENPDAPLPREMIDLEATFEKLENELREVNKNEETLKKNFSELTELKHILRKTQTFFEEHEDMIASSAESSGIGEVLSADEEELSGRFSDAMSPLKLQLRFVAGVIQRERLPAFERLLWRACRGNVFLRTSEIDDVLNDTVTGDPVNKCVFIIFFQGDHLKTKVKKICEGFRATLYPCPDTPQERREMSIGVMTRIEDLKTVLGQTQDHRHRVLVAASKNVRMWLTKVRKIKSIYHTLNLFNIDVTQKCLIAEVWCPIAELDRIKMALKRGTDESGSQVPSILNRMETNEAPPTYNKTNKFTKGFQNIVDAYGIATYREINPAPYTMISFPFLFAVMFGDMGHGAIMLLAALFFILKEKQLEAARIKDEIFQTFFGGRYVIFLMGAFSIYTGFMYNDVFSKSINTFGSSWQNTIPESVIDYYLDDEKRSESQLILPPETAFDGNPYPIGVDPVWNLAEGNKLSFLNSMKMKMSVLFGIAQMTFGVLLSYQNFIYFKSDLDIKYMFIPQMIFLSSIFIYLCIQILSKWLFFGAVGGTVLGYKYPGSNCAPSLLIGLINMFMMKSRNAGFVDDSGETYPQCYLSTWYPGQSFFETIFVLVAIACVPVMLFGKPYFLWKEEKERREGGHRQLATIEIILVVLALVQVPIMLFAKPYFLYRRDKQQSRYSTLTAESNQHQSVRADINQDDAEVVHAPEQTPKPSGHGHGHGDGPLEMGDVMVYQAIHTIEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVFRNAFVLDGYTGAIATYILFFIFGSLSVFILVLMEGLSAFLHALRLHWVEFQSKFYGGLGYEFAPFSFEKILAEEREAEENL 935
2 -87.200[C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I  ali follow..  15  3...........GRSLMSRPKEMTRAVIVGHKSILKQTIDSLYDTNLFHIEDFVEDESGFK--ISKPLKNAEEVSKKLVKIRSIANYLGIVHKEPV---VQKTDSVLRDLDSKLDELDRAIATKTDAIAQLENELKDLDSQKRELMPYLAI------------------------------NLDFDDYRGYESLKVFAGMVKGNLDGSQISSI-------------------TKAYELYFDPQSKAIVLFVAKSDADKVYELLQGIGFRELRVPERGGVPSELLRFIEQKEAEVTRKIESLRNEIESLKTKYADFILASDEILSIESQKAELPL--RIATSANAFIIEGWTPTENYDKVVSAVNSATNGK-AYVSSLEIEEEEEEHVPVEYNNSKVAAPMQQIMDLYSRPKYTELDPSSVILITFPLMYGLILGDIGYALILGAIALAVKKAIKSDAVGDLMN-----------ILIYCQISTFIFGIIYGEFLGFSLASLHTEHGSVPGLIPG---------------------WETIVLFEGLGGEEFTFPIHRTHMVMTM-IAVTVLIGLLQLNLGFLLGFANISKHHGVKHAVLEKGSWLVIELGVLLAAIGYLGGTGLAYVGAVVL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGIVMLTMGEGIKGPIELPSLMGNALSYARIIAVGLSSIYIASTVNDIAFEMIWADHS--KIGFVAIAAILVFILGHALNTVLSIIAPGLHALRLQYVEFFGKFYEGGGRKYNPFGYIRKYTEE....... 654
3 -9.340[O] KOG2090 Metalloendopeptidase family - mitochondrial intermediate peptidase  ali follow..  8  36FDHLKTAKGFQRFVADAIERSGELVSYISGMPSSPEIIKAMDEISDTEFVEEANKAAIEMNDYLHHLNTNHTLYAAVKKAEQDSNLLTKEASRTAHHLRMDFERGGIHLD---PEKLDKVNNLTTNIFQLCREFSENIADDPGHVDIFPGSRIPRHLHHLLNPTYRSTSGGSRGSTRSAHKSKQKGFRINTDPRTVSSILQWTSDEEVRKMVYIQGNSVPHANHGVLEKLI---------------------AARHELSQMMGCNSYADIMVEPNLAKSPKVVTSFLQELSKADEEFIAIRDFKREKCGNPSAELEPWDETYYTSMMKSSINDVDTAVVASYFPLGESWHPNVVKLSL-------HHPDEGDLGYLYLDL--------YSRKGKYPGCASAIRGGRKISETEYQLPVIALVCNFIVKLNVLFHEFGHAL---------------------------------HSLLSRTDYQHFSGTVALDLAEMPSNLF-----------------EYYAWDYRLLKRFARHYSTGETIPEKL---------NSLQGARNMFAATEMQRQVFYALIDQMLFGEQPETARDVSHLVAELKRQHTSW--LLNYGAGYYSYLY--------------------AKCFASTIWQSICEEDPLSLNT-----------------GTLLREKFF--------PAELLTD--LAGKEIISVHGEGIVPATTNPRFAIKCQNSQIESDTTEDPSRSKNSSSSGVGFGSPASSSSPAKKLSAATSGNKKGKGKREVNRRAPVEKPVFMSEEGAAKAE----------EQRQNENAFLLTWLGLGIVILIEGII------------LAASGFLP-LDKLFVKYVYPVFTPSVVLFVAGTTAY-----LKYIQ--NEKMKGQ....................... 859
4 -8.210[K] COG5164 Transcription elongation factor  ali follow..  9  101.AQATLNTDSSEANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDDDEDDDDEAPTKRRRQ-RFLDIEAEVSDDEDEDEDEEDSELVREGFITHGDDEDDEASAPGARRDDRLHRQLDQDLNKTSEEDAQRLAKELRERYGRSSSKQYRAAAQDGYVPQRFLLPSVDTAT------GVRCRPGKEKELIRKLLKKKF------NLDRAMGKKKLKILSIFQRDNYTGRIYIEAPKQSVIEKFCNGVPDIYISQKLLIP----------------VQELPLLLKPNKSDDVAL------EEGSY---VRIKRGIYDLAMVDQISENNLEVMLK--VPRLDYGKFDEIDPTTQQRKSRRPTFAHRAPPQLFNPTMTYKNEDYIDGY--LYKSFRIQHVKNIQPTVEELARF----TFQPGD-GEGIVTRTTKATIKLNGFTTPLEFPISTLRKIFEPGDHVTVINGEHQGDAGLVMSTQTSREVTITAN------NLSKSIDTTATSSEYALHDIVELSAKNVACIIQAGHDIFKVIDETGKVSTITKGSILDTIVEKVGSRREGQVLYIQTQQIF.......................................................................................................................................................................................................................................................................................................................................................... 732
5 -8.180[S] COG5373 Predicted membrane protein  ali follow..  11  16.........................................................................................................................................................................................................................................................................................AFLGGRRSAERLDREIESLKAEIARLAKEGMGEPGPDLATGRPSEAGVPSVAG----------------EATADGPWSRAREGAGTSHDESAAGRESGDGAIDGPVAPSAAAARAESLESRIGGRWPVWVGGL------ALALGGYFLVQYSEAG-GLALGVAGEVIRRRDVPAIADRFRNAMIPGVLTAAGAVTLFG--VVYAAYGIYDFIGTGAAFV-------------------------------------------------------LALVSLATVGLSLLHGQALAGLGLLASLL---------------TPLFV-PWVLFGFLAVAWL-RW.......................................................................................................................................................................................................................................................................................................................... 290
6 -7.840[G] COG3459 Cellobiose phosphorylase  ali follow..  11  227............LEERLHAAGTDAENVMMSEHTMGNIVKSLREIDDTEWSVWFEEVSHIDKVLREE-NTIELLARRSPRTEVEVARAAVEMARSDLPAGADENHRVNVGSVLVGQRRFELEKALGYRPLASQHIVRSMRKFNWLAIAAPVLLITAVAMLAVGWFLAKAGMPWYVVTAFLLMFALPASEGATGL-LVTFFVKPFRLVGYEFKNGIPEDARTLV----VPCMLTSRDSVDEMMRNIEVHYLANPHGEIYFSLVSDWRDAPYEQSDED----LEILDYAKRELAALNSRYAFDGKTRFYLLRIYNSAEECWMGWERKRGKLHELNMLLRGDKDTTFLGGA----NIVPADVKYVMT---DADTRLMRDAVTKLVGKMHHP--INRPKIDPVSGRVVEGYGL-----LQPRVTPSLTFQRVFS-LTSETGKG-LYDVDAFEAALKGRIEENSILSHDLLEGSFARCALVTDVELVEDF----YEVEVSRQHRWARGDWQLLP---------------------------------------FIIDRARGVTAIGRWKMVDNLRRSLTPIAWFFASILGWYFMDPLGALIWQILLIFSLFVAPTLSLLSGLVPRSTDIVPQAHFHTIWSEIRAT-MTDAIVRSLYRLLMLEWRTAASMQSSAQGSIVDYYRQMWHAPVVAMLGLLFAALPGDNAFLIGIPFTLLWVLSPAVAWYVSQSAETEDRLFVSEHVSFELRKIARRTWRYYEAFVTPQEN-----------LPPDNFQETPEPIVASRTSPTNIGVYLLSVISARQFGWISFADTLERIENTIQTVGHLYNWYHTDTLQLGPRYVSAV....................................................................................... 1074
7 -7.650[U] KOG1162 Predicted small molecule transporter  ali follow..  9  119................................................FARLDEELNKVNQFHKPKE---TEFLERGEILKKQLETLELKQILSDRKKRNLSGSNSHRSFSSSVRNSDFSAGSPGELSEIQSETSRTDEIIEALERNGVSFINSATRSKTKGGKPKMSLRVDIPDAVAGAEGGIARSIATAMSVLWEELVNNPRSDFTNWKNIQSAEKKIRSAFVELYRGLGLLKTYSSLNMIAF------TKIMKKFDKVAGQNASSTY--------LKVVKRSQFISSDKVVRLMDEVESIFTKHFANNDRKKAMKFLKPHQTKDSHMVTFFVGLFTGCFISLF----------------------IYIILAHLSGIFTSSDQVSYLETVYPVFSVFALLS-MYGCNLY--------TRINYTFIFEFAFLMGTTFMTSVVAAMVIHLILRASGFSASQVDTIPGILLLIFICVLI-VCSPFYKVLMVDFFSQIPLLRHLETTGCYFLAQSFKTHEYNTCKNGRYYREFAYLISFLPYFWRA----WWDESNPDHLINMGKYVSAMVAAGVRITY-LVSSVVATIY-----DFVKDW-DNLVLRNKNFYYLSIALVLRWIETIMRFRV-----SPVQSHLLDFFLASLEVI.......................................................................................................................................................................................................................................................................................... 744
8 -7.610[T] KOG3659 Sodium-neurotransmitter symporter  ali follow..  11  107................................................................................................................................................................................................................................DIVEGEKEGEERESWDSKIMFLLATIGYAVG-RFPYLAQKNGGGAFLVP--------MLCIQGIPIFYLELAIGQRLR---------KGAIGVWSQVSPYLGGIGISSAVVSYIVALYYNTIIAWCLIYLLHSFESPLADCPTRLYKNFTYDHEPECVASSPTQFYWYRTTLQCSESVDMP-GITSSGKI---VYMTAIFPYVVGITLKGAADGVAHLFTPRWETLLDPVVWLEAGTQIFFSLGLAFGGLIAFSSGTSMFAGVVVFSVIGFKATATFDRCTEERNGLVAQNKTHNLPVCDLQTELANSASGTG-IFTLGIDSQFGTLEGVVTSLVDMKKEYIVGALCFSCCTISMCFANGAGSYIFQLMDLLIIALFECLSISYIYGVIEMMTGSRWMFCWK---------------SPCAMVTILLASFYQLLTEGSSYPAWIGSKGATEGMEWPHCIVVAFFLILSSILWIPIVAVLR....................................................................................................................................................................................................................................... 661
9 -7.530[D] COG1196 Chromosome segregation ATPases  ali follow..  11  621............LGTTILAKDLGANTLARLVNFRYRIVTLEGDVGSMELGQLAEKIAELNNSTRELESAVQVAKDSMSKKREELEETRVIGENLR--------LQEKELLGKLDRETENLERFNKQLQLYDIEKADGSEELNKLLERKETLLQEQVEIAKQIEKTDEEIKAMTSSSKALESKRTADLESLSSLKAQIAAKREQL---------QSAVEAVDRVTTTLHENYEQKEAAEQKLASLKTNLSSVHTSEESARKSIEELRKDKAETSEKLNQTRQTRTELQEKIELLEAELTQKNNQISFYVEQKNNEISIGRLEVDITNRIDRLQEAYLLTPEQAEEKILPEVDTEQARSKVRLLKRSIDELGIVNIGAIEEFDRIQERFDFLQQADLLAAKETLFKV-----MDEMDEEMFEAIKFAIVFPELFGG-GSAELVLLTGIDIVVQPPGKKLQN-----LSLRSGGERALTAIALFAIIR----------------------------------------------------RPVPF-LDEV-ALDEANVTRFSRYLKTQFIVIMEEADVLYGVTMQ................................................................................................................................................................................................................................................................................................................................................................. 1166
10 -7.370[R] KOG4678 FOG: Calponin homology domain  ali follow..  12  278.GSSPNSVSELSLASL-KIQKMEENH-HSTAEELQATLQELSDQQQMENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEF---LELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEML-RAEKDLLELSCNELRQELLKANGEKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEE---TEEW--QADLQTAVVVANDIKCEAQQELRTVKRKLLEEEE...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 677
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.