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Query: [U] KOG2215 Exocyst complex subunit, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLSNEDGLFQTDAFSPSDYIRDRLKGVKIGDETRKLRHLRSEMGALNHASQETLKNNVFRNYQQFIDASKEISHLEREIYQLTHSLIEQKQVIENLIMMTGDDKSSIHTVSSHSTTTSTTNPIQILMQKMEGIGGILNNMSTSEKVILYGEMEQFDVETKKPVQKCMLILLSHRLIIGNINAAGKYVMESTLSLNSVAPVNVKDRESGAANAGKVLKLLIFPESRCYLCESARIRTLWFDELEQAKREILHKGSLVRQATIRGKRQTVKERKAAASSAIEEKPSFLEEEEDVGDENEERNDNDISWLSELPAELDDCIAHRDLDQAVELIHEWKQCPTKDAVIDIQLQMRENTIVQLLSDDVSRPGAVHGGPRAMKKARTLLTQLGRGTYATDVYLRRRSAMQRSAMRDVTVSEEPISYVKQLCTLYGNAVSDIANEFRSMPQYYCQVLQWCSYELSTLLNLIRRHVIEVAPAIAVIAYTWKNVMHTMEDLTAIGVHLNFEVNRLLSIPLEKSLQGNFENICDAVKMRISEEKWRPYVLESESALNRLVEELSDVGINVEWAISANDESRSSLNVSQNVVHFAKVAHTLSKDLAPLRLSPIQVLCEVYADELWKMYLQHLADNIRDGAVFAYSTTFILTMVLPVCDKILYGEEGELIRLIDQFPSLAPYADPSDEEKKDDEEVAHVLast
1 -158.000[U] KOG2215 Exocyst complex subunit  ali  100  1MLSNEDGLFQTDAFSPSDYIRDRLKGVKIGDETRKLRHLRSEMGALNHASQETLKNNVFRNYQQFIDASKEISHLEREIYQLTHSLIEQKQVIENLIMMTGDDKSSIHTVSSHSTTTSTTNPIQILMQKMEGIGGILNNMSTSEKVILYGEMEQFDVETKKPVQKCMLILLSHRLIIGNINAAGKYVMESTLSLNSVAPVNVKDRESGAANAGKVLKLLIFPESRCYLCESARIRTLWFDELEQAKREILHKGSLVRQATIRGKRQTVKERKAAASSAIEEKPSFLEEEEDVGDENEERNDNDISWLSELPAELDDCIAHRDLDQAVELIHEWKQCPTKDAVIDIQLQMRENTIVQLLSDDVSRPGAVHGGPRAMKKARTLLTQLGRGTYATDVYLRRRSAMQRSAMRDVTVSEEPISYVKQLCTLYGNAVSDIANEFRSMPQYYCQVLQWCSYELSTLLNLIRRHVIEVAPAIAVIAYTWKNVMHTMEDLTAIGVHLNFEVNRLLSIPLEKSLQGNFENICDAVKMRISEEKWRPYVLESESALNRLVEELSDVGINVEWAISANDESRSSLNVSQNVVHFAKVAHTLSKDLAPLRLSPIQVLCEVYADELWKMYLQHLADNIRDGAVFAYSTTFILTMVLPVCDKILYGEEGELIRLIDQFPSLAPYADPSDEEKKDDEEVAHV 686
2 -38.000[U] KOG2069 Golgi transport complex subunit  ali follow..  10  1MAMEVGEMSSLASATQQPYVSELLS------TLDRLHKEPELLRVDAERIQRQMQEVAVGNYRAFITAADALLAIRQEVSSIDKHLESLILKLVEVGGVRGIVFGAFNSFGIGEVPKLTSDSAENILEKRKMNQALLANHSTLLDLLEIPQLMDTQSLADLLPGVSNFWMCTYLF-------------------------------------------------------------------------------------------------------------------------------------KMICVFVRCVRNGNFDEALDLEAFVSKLATLHPKLPQALAAEVRQTTQSLLSQLLQKLRSNIQLPECLRIIGYLRRIGGEYEMRLQFLRCREAWLTGILEDLD-QKNAYEYLKGMINCHRMHLFDVVNQYRAIFSDDGLLFSWAMHQITSHLKTLKIMLPKIT-EGGSLSNILDQCMYCAMGLGGVGLDFRGLLPPLFEEAVLNLFSKNMSTAVENFQLVLDSHRWVPLPSVGFPSSGINEDSKDDV------------TPPSYLMEHPPLAVFINGVSSALNELRPCAPLSLKNVVAHELIKGLQAVSDSLLRRLSESNLFLSLCRAFVEVVFPHCATCFGRCYPGGATIVMDAKSAYEGLGRILAASSSQE..... 565
3 -19.500[S] KOG2346 Uncharacterized conserved protein  ali follow..  10  63........LNGAHFDPEVYLDKLRRECP-----AQLMDSETDMVRQIRALDSDMQTLVYENYNKFISATDTIRKMKNDFRKMEDEMDRLATNMAVITDFSARI------SATLQDRHERITKLAGVHALLRKLQ----------------------------------FLFE-----------------------------------------------------------------------------------------------------------------------------------------LPSRLTKCVELGAYGQAVRYQGRAQAVLQQFRAIQDDCQVITARLAQQLRQRFREG---GSGAPEQAECVELLLALGEAEELCEEFLAHARGRLEKELRNLEAEPDVLEFTDHGGSGFVGGLCQVAAAYQELFAAQGPLAAFARQLGSRYFALVERRLAQEQGGVRALDRFHRRLRAPGALLAAAGLAATEIVERVARERLGHHLQGLRAAFLGCLTDVRQALAAPRVAGKEGPGLAELLANVASSILSHIKASLAA------HLFTAKEVSFSNKPYFRGEFCSQGVREGLIVGFVHSMCQTAQSFCDSPGEKGGATLLLSRLCLDYETATISYILTLTDEQF................................. 550
4 -16.100[T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3  ali follow..  10  262............AFHSKFLLPELEKRMQEWETTPRIGEYVKGFDNAMELVKNMTERI--PQFKSVVEMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQER-YLFLFNNMLLYCVPKFGSKFTVRTRVGIDGMKIVETQNEE-----YPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAE............................................................................................................................................................................................................................................................................................................................................................................................................................ 548
5 -15.300[U] KOG2176 Exocyst complex, subunit SEC15  ali follow..  8  2............DIDVLEFVDKIASIESAGDTLDRLTQVYERLNELASKSAIRVEQLSAENNQDFSKSVNQLSVVRSELRSLQSLMADLNTDIQA------SGRDLQNMKQQLNSLSTSERFLTKYHNLVRSCMQVLHQVQYSQELLSKKQYLP--------------------------------TLRICSEISEVHLKRLDGLGMYSTIQQYIVTTKEA-----ICSAVMEDLHEWLFSIRQKLPLVGKSCSQQIDEARRRWAREYKEDLVNLSSKTSISLEL-------------------------------------------------------------------YLLEMMDFSPLDNEIVKISFEPLYICLQVHSYLGLLSSFRSSFERDRRRQQEFLAPKSLTTLDMAVVSEWLNSIAFMIVEYYILQCIPNFRSYEEV-IW-TIICEKLVETILSVAFTEQ-STTTIIKLKNQIVLLMHTMERFGFSVE--LRNLCVELIDAFGGALILKHSVFFEEAFEKDVYAPMIVETQEEYDHYIAPY---------WNFPSEPFPRTMSFSKMCPLCCTTLSKFVRHFFMFLNTEVNEKAPRFYRRFILRSLVDRKLALSQMSQLVKNFYAFEDPL............................................. 535
6 -15.200[U] KOG2347 Sec5 subunit of exocyst complex  ali follow..  10  160........FTSENFSAAWYLIENHSNTS-----EQLKMAVTNLKRQANKKSEGSLAYVKGGLSTFFEAQDALSAIHQKL-------------------------------EADGTEKVEGSMTQKLENVLNRASNTAD-------------------------------LFQEVL----------------------------GRKDKADSTRNALNVL----------------------------------------------------------------------------------QRFKFLFNLPLNIERNIQKGDYDVVINDYEKAKSLFGKFKKYYAEVETRIEALRELLLDKLLET---PSTLHDQKRYIRYLSDLHASGDPAWQCIGAQHKWILQLMHSCKEGPHRVAFVEKLTKLVLSQLPNFWKLWISYVNRQNDFKKMIQEVMHSLVKLTRGALLPLSIRDGELAHAIQTVRLTHESLTALEIDLLQTIQDLILDLRVRCVMATLQHTAEEIKRLAEKEDWIV----DNEGLTSLPCQFEQC-------------------IVCSLQSLKGVLECKPGEASVFQQPKTQEEVCQLSINIMQVFIYCLEQLSTKPDIVLSNCCYLERHTFLNIAEHFEKHNKITQVSMASLKELDQRLFENYIELKADPIVGSL 775
7 -13.400[S] KOG2939 Uncharacterized conserved protein  ali follow..  8  76INSIDAAYFIDNEFDAIDYELKKLCDIE--MCYEDIQRERFRLKSQHTVVSKKISTLIMQKSSSYTAQVGEMEKIRDEVGSVINEILTIRKALA-------LATSQTRTCLGLIAYKNKKIVLNQLKMTLTTIKGFHETEQHIRETIEEGNFIQMLIETQIKAGGYAHFTCVNEVISKLAGMSCLLEAELSAQLSTIAVV----DSEKYRFVYTAYEMLEKTEQVA-----EKLLTAFVEAIETTTSAVVLSKLKEEDRLEDSSYTSLCLKLDSEQ---------------------------SITFREMGFVLRSFQAFHKILNFHSSESASEASQSIYKQLLASRTEVFLAATRRLQVLVESRDFVSLKFEHILDIVDTINRF--NNIGKTYFASTHHQKLAESIEK-----RTETYFDRYHTERMEELSMFFEN------------SFALCPVPFQFTIFDLQDFEFLKESVRIESSPKSREESENSEEETVEL----------NDWQNPFCQAAIRSRLQSSYSQKSERSYSTSSAATEIQNENYNPNLTKQESFSEDPLDEPSGVPPPNLCNTALNLLRFFGRYLRMTALL--PTLCSKSAPAIIDLYEFFFASMCHMFGSEGAEFVGRIPRLVACLDGISRKF..................................... 658
8 -13.300[U] KOG3691 Exocyst complex subunit Sec8  ali follow..  9  1MAAEAAGGTVSKSKDPSGLLISVIRTLSTSDDVEDRENEKGRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKMLLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLV----------SAVESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIDELHR--------------------HLYIKSTSRVVQRNKEKGKISSLVKDASVPLIDVTNLPTPRKFLDTSHYSTAGSSSVREINLQDIKEDLELDPEEN------------------STLFMGILIKGLAKLKKIPETVKAIIERLEQELKQIVKRSTTQVADSGYQRGENVTVENQPRLLLELLELLFDKFNAVAAAHSVVLGYLQDTVVQEDIKLYMADVWVKIQDVLQMLLTEYLDMKNTRTA-----KFESSSHAISMSAYLREQKPGARNITVIFHPLLRFIQEIEHA---LTVYIKNIFLNQVLAEINKEIEGVTK------TSDPLKILANADTMKVLGVQRP-----------------------LLQSTIIVEKTVQDLLNLMHDLYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSL..................................... 652
9 -12.800[T] KOG2996 Rho guanine nucleotide exchange factor VAV3  ali follow..  11  200IKQTEEKYTETLESIEKYFMAP-LKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDVIYGQYSGVESAISSLDYLRDLLVVPMQRVLKYHLLLQELVKLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEI-RITTLDKHTKQERHIFLFDLAVIVCKRKG-DNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHD.......................................................................................................................................................................................................................................................................................................................................................................................................................................... 515
10 -12.600[U] KOG2180 Late Golgi protein sorting complex, subunit Vps53  ali follow..  8  38......DPMDAPDFNTVDYINQLFPN---EQSLAGIDETIQKMQCEVSLIDDNIRSVVRGQTNTGQDGQLALCEAQKVISSLFSHIIDVKTRAERTEEMVKEITRDIKQLDCA------KRNLTAAITTLNHLHMLVGGIESLNKLIERRSYGEILNPLQAITEVNQHF-FSDIEEIKNLSQSVDKIQVTLAQQITEDFKEAFSAKPSSQNQHRLGLNQLADACKVMSVLDPKVKKELLKWFIAQQLEEYTHLFHENQD------------------------------------------------IAWLDKID-----KRYAWLKRHLLDFEDKYGPVFPLDWEVSERTVEFCRQTREQLAQIMAKRTNEIDVRLLLFAINKTQAFEQLLSKRFTGVTLGAQPTDKARVLAEPTTTDGAVGLTVFHDQIGQCFKPH---------LDIYIRSIDRNLSELMDKFVEMSREPYPSSGDLFVFYKKCMVQCNQLSYDLALVFKKYLREYASKVLEGSTPKLVPATTSSSIGKSVSLLTRDMQNLSTAAGQVFHNFLKEGDTQRFARDDLVRICCVLTTGEYCLETVQQLEDKLKEKVTSAYVSKIKDVFHRIISNCIQLLVQDLGDQSAFISSLCGNFKQTVPTIRDTLASSRKYFTQFCHRFVAAF................... 671
11 -12.100[T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases  ali follow..  11  455VIYTERDFVRDLEYIRDFWIKNVIPENNRQQFIRCVFHNIMQIHAVNSRLSNALNREPFIKYANYVHLTKPTTRLARYPLLLSGVLKYTDKDNPDTENIPRVIEMIREFLTKLNYETGKTENRLSLLQLNEQLS--LTLFDPSRLLIFKGVVKLKASSYSNGDTDIHMFLLDNFLLLCKIKIQMKRRHLRPLPLELLSISYIEDSPSRGSLPRRLVFIGARGFSISLYLNTLIARDQWKQHIEKQQDIIRKRHLVFESRGICCQSWFTGNKLLCAVAYDAGRKLLFGTYKGLYISSRKSNNGSCLEPIFKLQLPNISQLDVIEEHNVLLLLAEKILYELPLDALDSVEQINSKSLRRVTGHVSRILVCAVKSTVLNTTLRIYEADRALKNKKEVQMPMEALSVHFLKTKLNPADTSFRFLEKREDIRPIAMFRLRGEFLLCYSDQSWMINW-EGQPQGCA-LCYPYILAFEPDF------IEIRNAETAELVQIGQNIKLL......................................................................................................................................................................................... 1113
12 -11.900[U] COG5173 Exocyst complex subunit SEC6  ali follow..  7  2...............SSDPLQQVCDLIKGDLSLERVRDIKEQLLKEKSVVEYQLNKESDKYYGEVEESLKLLNLSKNSVTSIKQQINEVNKLGND-------NRFAINRYDILFRATKLYETVNTTSSIYDRIYNFVALMEHIERLLVAELAEDALETGCPHLLEIHFLLFQEQVVVMAKEATEDAQRTVMKLFSRLSGIISKFDKLLDGLTYDIVEMARAEQISLAIYDLEEREDLRIEAIRNIIKKKEIEIEKSSIKKLPNSKNTARLQDETPKVIEYPTNKGLYQEIMSGTISTRTAPRGYK--NSISEMFGEMREKYVGDQKFDVLDNMDWIFNELIIVKEHIEVYFDQYYKELHSLITDLVESEPETIIILDILAFDKTF---QDTLKQDFGFTKSEVKSVIGDKEKETLFKDYLNLIV---------------------VKMTEWIGNLEKAEFDVFLERSTPPHSDLDGTKTCFQMFTQQVEVAAGTNVGVVERFSDLLTKRQKNWISKISEEIKKQINYNHKYDIDPESITPEDECPGGLVEYL--------------------IAVSNDQMKAADYAVAISSKYGKLVSKVYEKQITNHLEGTLDGFAEVAQCSSL----------GLITLMFDDLRKPYQEIFSKTWYMGSQAQQIADTLDEYLLDIKP....... 642
13 -11.800[S] KOG4182 Uncharacterized conserved protein  ali follow..  10  1...MDFSKFLADDFDVKEWINAAFRAGSKEAADGHAATLVMKLQLFIQEVNHAVEETSHQALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQS----------------MQVLVEIDQVKSRMQLAAESL--------------------------------------------------------------------------------------------QEADKW---------------------------------------------------------------------STLSADIEETFKTQDIAVISAKLTGMQNSLMMLVDTCVHLEALKNRLEALASPQIVAAFTSQ-AVDQSKVFVKVFTEIDRMPQLLAYYYKCHKVQLLAAWQELCQSDSLDRQLTGLYDALLGAWHTQIQWATQVFQKPHEVVM-LIQTLGALMPSLPSCL-GPEQELTRLLEFYDATAHFAKGLEMA-TELVDAVYDPYKPYQLKYGDMEESNLLIQMSAVPLEHG---------------------------------EVIDCVQELSHSVNKLFGLASAAVDRCVRFTNGLGTCGLLSALKSLFAKYVSDFTSTLQS............................................................ 442
14 -11.200[F] KOG2070 Guanine nucleotide exchange factor  ali follow..  10  258ILETENEYSKELQTVLSTYLRPLQTEKLSSANISYLMGNLEEICSFQQMLVQSLEKTLYLTYGEFMELSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKEELQILTEAIRNWEG--DIKTLGNVTYMSQ--VLIQCAGSEEKNERYLLLFPNVLLMLSASPRSGFIYQGKLPTTGMTITKLEDSEN----HRNAFEISGSMERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPS.................................................................................................................................................................................................................................................................................................................................................................................................................................. 578
15 -10.000[R] KOG3518 Putative guanine nucleotide exchange factor  ali follow..  10  552IVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQI----EEIYEFNSMLLQRLINDVYTTYYSLLALLKPVQRILKYHLLLDSLRKHCDV--KEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLG----------LTVLGELRQEGLLMEQHNKQRLVLLFATMLIITKQKEDGRLQFKTYISQNNLMLSEHLPGEP-------SFYV-EPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECFPL............................................................................................................................................................................................................................................................................................................................................................................................................................. 866
16 -9.190[U] KOG0412 Golgi transport complex COD1 protein  ali follow..  8  1.................................................................................................................................................................................................MSVLEQLGALDIGTNEQVDETLQRIADEEAKVNEKLESLLAKQ---CQIEAKMSGIGRSLSLLHTVDSDSNKLNDQIVNTAQLAESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLSDAVKTLEDATEKTRVLIAKRFDEAVKAD-DLASVERFFKIFPLVGCHRTGIEKFSLYICQKLANKAQKEAESRLQLAYADRLTAIL-RVVEVNQPIIEAFYGQASSSLIDMVSILQHECDTEVKNLLMEFNKNRQIQYRSKQVNESTQRSAGGG-EIDAIIAEITVELYFRFMRRRLQARRKGSHKMQFDIMERYEKIMKNSDLRRQMQEILSTYLLLERYFMEESVLKA---IGLDTYESGQQCSSMVDDVFFILRKSIRRALTTQSINGTCAVINNVAACLDG............................................................ 484
17 -9.060[T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)  ali follow..  9  366..RVCMEMVETE----KNYLSLL-NEFMSRSDVAMMFGKLDPILELHERIFARLTVKAYPQYSKFHTFCKAKESLTDLMVKPVQRLPSVILLLKEMAKAEEAAKAIDEVLKTANKTREKNDNFISHLSKFTDIENVPILVAANRMFIRELVVSPIASTS-QQFAKMKLFLFHDVLIITKIRSEKNTMQR-----RHASFASLHSRQRRPYRYIDQIQLNTMRS--AFRIRAPDEIAKCLELQQQNGSTKPN................................................................................................................................................................................................................................................................................................................................................................................................................................................... 694
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.