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Query: [E] KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINQASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFTLast
1 -136.000[E] KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases  ali  100  1MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINQASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT 558
2 -93.300[E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase  ali follow..  34  6..................................................................................NLVTSTQGIIKEALHKLGFDEGMYDLIKEPLRMLQVRIPVRMDDGTVKTFTGYRAQHNDAVGPTKGGVRFHPDVDEEEVKALSMWMTLKCGIVNLPYGGGKGGIVCDPRQMSIHEVERLSRGYVRAISQ--FVGPNKDIPAPDVFTNSQIMAWMMDEYSALDKF---NSPGFITGKPIVLGGSHGRDRSTALGVVIAIEQAAKRRN--------MQIEGAKVVIQGFGNAGSFLAKFLYDLGAKIVGISDAYGALHDPNGLDIDYLLDRRDSFGTVTNLFEETISNKELFELDCDILVPAAISNQITEDNAHDIKASIVVEAANGPTTPEATRILTERGILLVPDVLASAGGVTVSYFEWVQNNQGYYWSEEEVNEKLREKLEAAFDTIYELSQNRK----------------------------------------------------IDMRLAAYIIGIKRTAEAARYRGWA.. 414
3 -21.400[E] COG2902 NAD-specific glutamate dehydrogenase  ali follow..  16  720..........................................................PNLDEDRTLRRYVNAIDATLRT--NYFQKNADGTPRDLLAFKFDPKHLDGLPDPRPFREIFV---------TEVEGVHLRFGKV---ARGGLRWSDRGQRTEVLGLVKAQQVKNAV--IVPVGAKGGFFPKNRDEVFNAGREAYKTYIRTLLPADTLRLDGDVVAADKGTA--TFSDTANGLAHEAGFW---------DDAFASGGSAGKMGITARGAWETVKRHFREMDT--------DIQTTPFTVAGVGDMSGDVFGMLLSEKIRLIAAFDHRDIFIDPDPDTDKSFAERKRPRSSWQDYDRSTLSAGAILKAPTDLLIKAAVENDPIRVNATELRAKVIGEGANLGITQKGRIAYALAGGRCNSDAIDNSAGVNSSDVEVNIKLASAVNSGRLTMPKRNQLLASMTPDVAQLVLRNNYQQSLAGLANREELGRLMGALEATGQLNRKVETL---PNNAEFSERYASGKPLTRPEIGVLLSYAKL............ 1268
4 -7.850[H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1  ali follow..  12  31........................................................................................................................................................................................................................................................................................................DILRAAHVCVIGIGGVGSWAVEALARTGIGELTLIDM-------DDVCVTNINRQIHAMTGTIGKSKIEVMAERVKLINPECKV--LVDDFITPDNQHLYSFDYVLDAISLKAKASLLAYCRSNKIKVITVGGAGGQT............................................................................................................................ 164
5 -7.500[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  12  2.........................................................................................................................................................................................................................................................................................................SHTKPSIAILGAGRVGSSLARSAVAAGYEVK--------VAGSGAVDKIALTAEILMPGAVPSTADQAVKDA-------DIVFLAVPLHKFRSVNPATLEGKIVIDTMNHWVPVNGELEEIDQDPRSTSEIIAEAGSTMVKSFNHIGYHEIEQDAGTGRAIAYATDDVDAGAQVAQLIKSFGFVPLNIGALENGRILEPGQEAFGAHLNKDSRLELVNQ.......................................... 207
6 -6.700[C] KOG1257 NADP+-dependent malic enzyme  ali follow..  11  73..........................................KKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTP--TVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTGERILGLGDLGVYGMGI---PVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPKRDRTQQYDDLIDEFMKAITDR--YGRNTLIQFEDFGNHN-----FLRKYREKYCTFNDDIQGTAA---VALAGLLAAQKVIS-----------------------KPISEHKILFLGAGEAALGIANLIVMSMVE-LSEQEAQKKIWDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAPSTIIGVAGAGRLFTPDVIRAMASPVIFALSN---TAQAECTAEEAYTLTEGRCLFASG----SPFGPVKLTDGRVFTPGQGNNVY----------------------------VALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAI-KVTEYLYANKMA.. 540
7 -6.630[O] KOG2013 SMT3/SUMO-activating complex, catalytic component UBA2  ali follow..  14  21........................................................................................................................................................................................................................................................................................................RNFKSAKVLLVGAGGIGCELLKNLLMSGVKEVHIIDLD--------IDLSNLNRQFLFRKKHVKQPKAIVAAKTASSFNPNVKL-EAYHANIKEDRFNV-QFDLVFNALNLDARRHVNKQCLLASVPLIESGTTGFLGQVQVIIH..................................................................................................................... 161
8 -6.590[O] KOG2018 Predicted dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis  ali follow..  17  122........................................................................................................................................................................................................................................................................................................ERLRNSFVIVVGCGGVGSWVINMLARSGVQKIRIVDF-------DQVSLSSLNRHSIATLQDVGTPKTLAIKKAIKKFAPWIEV--ARNALFNPDSADDLNPDFVIDAINIQTKVDLLSYCYNHKLPVIASTGSACKS............................................................................................................................ 255
9 -6.560[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  12  2.............................................................................................................................................................................................................................................................................................................LKIGIVGCGFIGGQICRAIDGGSAELYALCD----------SSESKALELAASLKT----CKPSYMKIEELIRGVDLIIESASQNAVRFIVPQALKADVMILSVGALADEELRDTLFG........................................................................................................................................... 109
10 -6.160[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  15  1.............................................................................................................................................................................................................................................................................................................MQLGMIGLGRMGANIVRRLAKGGHDCV--------VYDHDPDAVKAMAGEDRTTGSLRELSQRLSAPRVVW-----VMVPAGTTAVIEELANTLEAGDIVIDGGNTRDDLRHEKLLFKKGIHLLD--CGTSGGVWGR----ERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRN............................... 213
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 5 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rodrigues AP, Grant BJ, Godzik A, Friedberg I. The 2006 automated function prediction meeting. BMC Bioinformatics. 2007 May 22;8 Suppl 4:S1-4.