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Query: [O] KOG2292 Oligosaccharyltransferase, STT3 subunit, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNRTPKMLNSKVAGYSSLITFAILLIAWLAGFSSRLFAVIRFESIIHEFDPWFNYRATAYMVQNGWYNFLNWFDERAWYPLGRIVGGTVYPGLMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELWSAGAGLFAASFIAIVPGYISRSVAGSYDNEGIAIFALQFTYFLWVRSVKTGSVFWSAAAALSYFYMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPFVGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWFSFFFDLHILVCAFPVGVWYCIKQINDERVFVVLYAISAVYFAGVMVRLMLTLTPVVCMLAGVAFSGLLDVFLQEDSSKRMGTAISAATEVDEAEDSIEKKTLYDKAGKLKHRTKHDAQQDTGVSSNLKSIVILAVLMLLMMFAVHCTWVTSNAYSSPSIVLAFHNSQDGSRNILDDFREAYYWLSQNTADDARVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSSTEEKSYEIMTSLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIKESDYFTDRGEFRVDAEGAPALLNCLMYKLSYYRFGELKLDYRGPSGYDRTRNAVIGNKDFDLTYLEEAYTTEHWLVRIYRVKKPHEFNRPSLKTKERTIPPANFISRKNSKRRKGYIRNRPVVVKGKRTLKLast
1 -185.000[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali  100  1MNRTPKMLNSKVAGYSSLITFAILLIAWLAGFSSRLFAVIRFESIIHEFDPWFNYRATAYMVQNGWYNFLNWFDERAWYPLGRIVGGTVYPGLMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELWSAGAGLFAASFIAIVPGYISRSVAGSYDNEGIAIFALQFTYFLWVRSVKTGSVFWSAAAALSYFYMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPFVGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTTWFSFFFDLHILVCAFPVGVWYCIKQINDERVFVVLYAISAVYFAGVMVRLMLTLTPVVCMLAGVAFSGLLDVFLQEDSSKRMGTAISAATEVDEAEDSIEKKTLYDKAGKLKHRTKHDAQQDTGVSSNLKSIVILAVLMLLMMFAVHCTWVTSNAYSSPSIVLAFHNSQDGSRNILDDFREAYYWLSQNTADDARVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSSTEEKSYEIMTSLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIKESDYFTDRGEFRVDAEGAPALLNCLMYKLSYYRFGELKLDYRGPSGYDRTRNAVIGNKDFDLTYLEEAYTTEHWLVRIYRVKKPHEFNRPSLKTKERTIPPANFISRKNSKRRKGYIRNRPVVVKGKRTLK 774
2 -160.000[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  51  1MATSKKGVKSHQKDWKIPLKVLILICIAVASVSSRLFSVIRYESIIHEFDPWFNFRASKILVEQGFYNFLNWFDERSWYPLGRVAGGTLYPGLMVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELKSDACGLLAAAFMGIAPGYTSRSVAGSYDNEAIAITLLMSTFALWIKAVKSGSSFWGACTGLLYFYMVTAWGGYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSSKQFQILIRFALVCLVGLATVVLFALSSTGVIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPPTWSSLFFDLQFLIWLLPVGVYLCFKELRNEHVFIIIYSVLGTYFCGVMVRLVLTLTPCVCIAAAVAISTLLDTYMGPEVEEDKVSEEAASAKSKNKKGIFS----------ILSFFTSGSKNIGIYSLLSRVLVISSTAYFLIMFVYHSSWVTSNAYSSPTVV-LSTVLNDGSLMYIDDFREAYDWLRRNTPYDTKVMSWWDYGYQIAGMADRITLVDNNTWNNTHIATVGKAMSSPEEKAYPILRKHDVDYILIIYGGTLGYSSDDMNKFLWMIRISQGLWPDEIVERNFFTPNGEYRTDDAATPTMRESLLYKMSYHGAWKLF---PPNQGYDRARNQKLPSKDPQLFTIEEAFTTVHHLVRLYKVKKPDTLGRDLKQVTLFEEGK---RKKLRRPAKTNEIPLR........... 751
3 -30.800[S] KOG4587 Predicted membrane protein  ali follow..  9  12.SKYSSDTSSSLYSQTWLASVVIIGLLVGYINYQHVYTLFENDKHFSHLADFLYYSYYKTIINAPSFLQEITHDTVTEHGHEINTLNRFNLYPEVILAFLYRPFRAFAKSANWQIFYITGVFIVAGTVASSIFYLGVLVSDSIGGFLSVLCFAFNHGEATRVQWTPPLRESFAFPFIIGHIAILTFVIKYKKHSMILLLTSMAVPALLFWQFTQFAFFTQICSIFLAFSLDLIPFSTAKTVIHSHIISFLIGFLLLF-------GNEMMITALYFPSILALGMIIYISPLLSNLKFRPAYVLFLAIIFASITLGLKIGLSKGLGIEDDAHIFDILRSKFTSFAN--FIQYSTIEKLCGTLLIPLALISLVTFVFNFVKNTNLENGEILYNVVQLCCSTVMAFLIMRLKLFMTPHLCIVAALFAN----------------------------------------------SKLLGGDRISKTIRVSALVGVIAILFYRGIPNIRQQLNVKGEYSNPDQE------------------MLFDWIQHNTKQDAVFAGTMPVMANVKLTTLRPIVNHPHYEHVGIRERTLKVYSKPIAEVHKIMKEMGVNYFVFQLMNCSNDERRPECVYRGMWDEEDPKNSGRTALCDLWILAANSKDNSR---------------------------------------------IAPFKIVYNANRNY-IVLKI.................................................. 683
4 -30.100[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  10  1MRRSRDDSSPR--------VAAAVVAVTAAALLARLWAL---GWRVAHQDEARVADWTLQYMDLGAWQ----YRPIIHGP------------FLPHVNGVVFDVFGAT-----DFTMRLVVAVVGGLLPLTAWLYRTRL-SDVEVGALAVLLAANPVVLYYS---FMRNDLLLAGFMFTAVGLFVRFLDTHRARYLYASAVPFALAFTTKENSLLYPLCWLGALALVTDDRMAVAGATDTSRLAVVRRAAARIRHRAWRAKAALAGSALTAAVIVVSFYA------------------------KPDLYRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTVAHSYVAFLSHDLSVLVACGTVVSVAAVVGYLANRYATETPRPLVSFAFYWGVFSVYPAVVDIATAVNALVPLAIPAAVGVGAVVRYGRRGAAAGDT------------------------------------------AAVRLAVTVLVVSAAGMGAVAAETTYAHPQSPSNPLVQYAQPGGT------MQPTIDDIQRAATATSGLDVLYGWW-Y------LSQVGANATTVQTAAEVPDTPPPVVISVVSEEDDFAALLAAAD...................................................................................................................................................................... 537
5 -23.500[S] COG5427 Uncharacterized membrane protein  ali follow..  8  95.....................GVFTVAFVFLIVVRAWA----GVQPAGGEQFLDFGLLQALDRAGQLP--MWFERVVYYYGG-----------QLMASIGAHL-----TDTAPRFAYEPALAGVYAMGCTAAYGLASTIAAGNAGVLGAFAFGFMETGLNE-LNGDLHAHMVSVPVLFVAVAVGVAYYRTRWALLWGGFPVAGAAILTTWS-LPTVFGVAALAVALADPAPATLLPTGVQRWTRRESAVGQSVQRVLLAVGVAAVGGVLAVVIAWPFVQNVLLAGASNQHLAVLPVPSQAGALVFVHGLFLAAFGAYFVSRVATSVAGWVVAAAAAGAAVAVAVAVGPVVG----------GVGITAVVLVGPVLGAAWWLRRRNAAGVECVLVAAGAGLVVTVFKVYAQVWALWSVAGGVALAGVSERRAST--------------------------------------------------GGLGAVFVVGLVVAASVYGGLAVTTHAANADDASLDALEYAGNAHPGE-----AAAARWLGDRRRGTRIVAA-YTWQNPAASLSGVPTVAGQAAWEQRVDDIGVVYETTDAASRAAILEKYDVTYVWVGPVERARYEIPDLSAD------------------------------------------------------------------------------PGIEPVHRTPA--VTIYRVTDDELVAITVTTTPQAATATAPGAQTARSPARFVTVTSSASTSQWGTKLR 838
6 -21.300[O] KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase  ali follow..  14  46.EDFSKEKPAAQSSLLRLESVVMPVIFTALALFTRMYKIGINNHVV--WDEAHFGKFGSYYLRHEFY-----HDVH---PLGK------------MLVGLSGYLAGYNGSWDFYVKMRLFNASFSALCVPLAYFTAKAIGSLPTVWLMTVLVLFENSYSTLGRFILLD--SMLLFFTVASFFSFVMFHNQRSWKWLLITGISLGCTISVMVG-LFIITMVGIYTVIDLWTFLADKSMSWKTYINHWLARIFGLII....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 294
7 -20.900[O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase  ali follow..  15  39.DAELYDKVKNESAVSHLDTIVMPIIFTVLGMFTRMYKIGRNNHVV--WDEAHFGKFGSYYLRHEFY-----HDVH---PLGK------------MLVGLSGYLAGYNGSWDFPSGMRLFQAMFSSLCVPLAYFTGRAIGSRLSVWLFTILVIFENSYATLGKFILLD--SMLLFFTVSSYFCLAKFHTMRKSPFSCLTGLNLGCAISVMVG-LFIISVVGIYTISELWNLLSDRSVSWKVYVNHWLARIFGLII....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 288
8 -20.200[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  12  1..............MKSVRYLIGLFAFIACYYLLPI-----STRLLWQPDETRYAEISREMLASG--------DWIVPHLLGLRYFEKPIAGYWINSIGQWLFGAN-------NFGVRAGVIFATLLTAALVTWFTLRLWDKRLALLATVIYLSLFIVYAIGTYAVLD--PFIAFWLVAGMCSFWLAMQKGKSAGFLLLGITCGMGVMT-KG-FLALAVPVLSVLPWVATQKRWKDLFIYGWLAVISCVLTVL----------------------GLAIAQREPNFWHYFFWVEHIQR-----------------------------------------------FALDDAQHRAPFWPVIIAGSLPWLGLLPGALYTGWKNRKHSTVYLLSWTIMPLFFSVAKGKLPTYILASLAMLMAHYALLAAK.......................................................................................................................................................................................................................................................................................................................................................... 336
9 -20.000[S] COG5617 Predicted integral membrane protein  ali follow..  9  1...........MKRKLYYLTLATISVIEYIPLYL------APSPPALQINGNGHLFKVHKLMTSGWKPWIE-YPFLRFYP------------LSYLTAGVLGKVLG-----SDTKGYAATLMLTSFLGALALHHYLKST--GREPCISPLIFLLFPWHLTVSYIEGNFPRANAIHLAPLFLLSLYWLREKRE-RYLIASALGISIVALT---HYSILPLLIITGILILWDDLRTMTALGNGIKVLGAVIGLTSFW--------YVPFLFDKKWVEFWNISENKALFKSFSLNPTLLKSPFGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGFYSPTTWLYSFPLLSIVPP-----YRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKI............................................................................................................................................................................................................................................................................................................................................................................... 359
10 -19.200[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  13  173...............................................................................FLGK------------DIIALGMLIEDKPFY------WRIPGIIEHALIVIIVTLVAYKITSYLASSIAATFAALDPLLFATGIVAMLD--IHVAFFIALFMLFLAL-------DRIRLSGIALGLAAATLSGAFAFPIL-----WFKILKEKDLKEYLISGLVLPMVSFLIPEIT------------IIKAIGFIPWLEEFIASFSWHLSFKGEHPSEAPFWMWFVSL----------------------FPFHFDPDVYAVTDPIL-----------------MISMIVFVFAVPYVSLRRKGLSEIFWMFWSIIAFYILGGKTQFIFYLIPPGAVALGVISYEIIK.......................................................................................................................................................................................................................................................................................................................................................... 449
11 -16.100[S] COG5305 Predicted membrane protein  ali follow..  10  1..........................MFSLGNSFLPVPLDQAIAP----DILLQPLQPN---ASGIGDVIHNLITEDNHP------------LYFVLVHLWMKLFPNQGELVSLLAARSFPALLGAVSIPLTYILGRLAFSSLVGQLAAGMMAVSPYAVYLGQ---VRHYTLAMIWVIASLSCLVIATRHIQNRTLILWVGINALGIATHYFFTLTLCAEALVLIFLAWQQSTQAKTLVFFSPLWWRIYAVAAGT------------AVAGLVWLPSILENRYRSSLTAWIQVQGIGLHLINPIFQAFAAWVTMIMLLPIESSQLAVVIASGLVMLIFAIWATPILVRGFKFQLQQPQTSLATQVFIGVVLGAIALF-----------FILTYIF-----ITRGARYNFVYFPAVIILVGASLA.............................................................................................................................................................................................................................................................................................................................................................. 361
12 -14.800[S] COG4485 Predicted membrane protein  ali follow..  9  1.......MKSFLKTYRTYFISFIIPVVIMSGVYLSQSIYWNSDNSPLLGDIFDVA--LRNILHGNSNLFYTF-----TSGLGLNF----YALSSYYLGSFLAPLVYFFDLTNMPDAIYLTTLLKFGLIGLSTFFSLNKLFPQILKLALSTSYALMSFTVSQLE--WLD----VFILIPLIITGLHLLITEKKLLLYFTS-LSILFIQNYYFGYMTVLFLIFWYLCQISWDFKTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAKQFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKFFAFLIASFYIEALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFLATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNL----------------------------------------FAILISLFILVEMSLNASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNYNGISQFSSVRNRSSSST--DKLGFKSSGTNLNLRYANNSILADSL--FGIQYNIS................................................................................................................................................................... 560
13 -14.500[MU] KOG2515 Mannosyltransferase  ali follow..  11  16.........................WTFSILAVLRLTSAS---RVIDDCDEVYNYWEPLHYLLYGY---------LQTWEYSPEYAIRSWFYIALHAVPGFLARGLGLSRLHVFYFIRGVLACFSAFCETNLILAVARNFNRAVALHLTSVLFVNSGMWSASTSFL---SSFAMNMVTLALSAQLSPPSTKRTVKVVSFITIGAVIGWPFSA------ALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICITVDSLFYHRIQFVAWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQHNIVLWFAMA------------------------------------------------CGPLVLLAAFTNWINLDSFLDLSSVIYIWLFIFIIQPHKEERFMYPIYPVLCLAAAIGLDMSLKLMIQILSSINET.............................................................................................................................................................................................................................................................................................................................................. 367
14 -14.100[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  13  1MAKALES-NSKSRKETILIKYAIFLLVLFLTILWRSL-ASRSLENSVVWDSVYFLR----ITECG----YEYEQTYAFLPL-------PFFISLLSRTVFAPLVPLIGLRAVMVLSGFTVSNLAFIFAAIYLFRVSVIILDTEASFRASIIFCFNPASIFYSSI----SESLYALFSIGGVYHLLSG-------TSNVGVLWFALSGCARSNGILNAGYICFQTMHRAYEALYQKRRAYLAMQVFIAGFLRCICI....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 261
15 -13.800[S] COG5542 Predicted integral membrane protein  ali follow..  11  1MKLNESAMKNAEKKKGICVCTFLLILYLGIAVIMSHL-FRTLFISWIRWDAIYFVD----MAVNG----SLFEQEWAFSS--------------LWPKIISFLAFRSKDVVLLGIVSCFASIFFHAIACYALYLLTKSIFNQKMTAYTVIFYCFSPSGIYMSVG----TESLFAAFSFLGLLLFIKK---------YPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVVGFLRYWTLNNIPNFLFALLSIIPILFALFYSISGSTLHSFRSIKSHLVLSALYLYIGCFHMHTQVLNRMSSAL-----------------------------------PLLYWSMAHATLYAKSRNLKAFGHCILFVWIVYTVIQAGLYGSFLPPA........................................................................................................................................................................................................................................................................................................................................................................ 426
16 -13.200[S] COG4906 Predicted membrane protein  ali follow..  10  182...............NRTFAIWSIAISLMWSTVFGVSW-----NYIWGYDINGEYYYANLVLARGI------WSISTYDQYN-----------TIASVNILGPVYSLILNMWIVPIFKIIYPLVFSLVPVILLKAYERLLGKIWAELSVLFFMFFFQFFVSNMA--LARMMIVEVYLALLAYATIRKINP------LFLILFLASLAVSHYGTAYLTMFALLTLPLIRVLENEQRISNKLIAVFWVVTLLLVIIGYQTLLMLKDLFNPQYSQGLELIVAKMTFMREIAKLIN----------LFAQGLISIGVLTVLNRLIRGRKVKHLEFYALSFAFFAYDIAGIVVPYFSNRMNVNRLYHLTQFFIAPYLLIGFDSVKRTLPLKNSVEIAGVFLVVYFIFTS.................................................................................................................................................................................................................................................................................................................................................................................. 554
17 -13.100[G] KOG4123 Putative alpha 1,2 mannosyltransferase  ali follow..  8  1MRLTTLWQNRSPGDRHLSTYFCFAAVRLLLVFVPQL---------YVHPDEFFQSVEVMTGDHFRLEHTRTW-EFNNSLPVRSIVLPFALLRIPWSFYEFVAECLELLGTYAYVVFPRLIYTLISFSNDYCLFRICRLYGLRFIRLLAMGSSWILLVFGTRTF-----SNSLEMAMCSWLLCLVSECMLRTNTVVYKKEFLEEKYDKAE----------SISERVRIWKLKNSLPAHNLQHLMAMSTICVAGVFN---------------TFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFIFCDSLYYQHLTLGELHVFTPWNFIKANLDSAQTASHGVHPCYVHLMVFNVLALASLGAFAQLLLRFFRAESGAIFVPLFFLSLI-QEPRFLLPVTFPLILLHAPKLITG............................................................................................................................................................................................................................................................................................................................................................ 425
18 -13.100[S] COG5650 Predicted integral membrane protein  ali follow..  9  50..................VLITTSLVFLAMGFLTKANCIQGSRGT-SGSRQYTSACYNDIVIDAPGFPYAF--TRYMEYP--------VLGGIFQWICGIITLYPVVDVIPFHTLPESGLYFIVTALALAFFWVLVIRMMVELTGVWDTVLVAASPLVA---VHAFTNWDTPAIAAVIGAMLAVKRG-------NPLVAGVLIGAGTAF----KLWPLYLLGAYLVLAVKNKNLKPFITMAAAAAVTWLVVNVPVMIAYPKAWNEFLRLNRERGAEWTTIYQVIDRNLPINLNDPVLLNVLSFGLFGASCVAILILGLKVQRTPRV----------------------------------------AELAFLIVAAFLLFNKVWSPQYSL--WLVPLAVLAFPQWKVLFPWMVTDAMVWPILMWHMLG.......................................................................................................................................................................................................................................................................................................................................................... 418
19 -13.000[MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis  ali follow..  9  5..........................FWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSA----------HPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVS--VGVRTF-----SNSLETTLTSIGFYYFSYYLKYENSS-KAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFN------------------------------------------------VTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSF............................................................................................................................................................................................................................................................................................................................................................ 349
20 -12.400[MU] KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family)  ali follow..  10  5..................VLDTVLLTVISFHLIQ---------APFTKVEESFNIQAIHDILTYSVFDISQ-YDHLKFPGVVPRTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMFDEITEKKKEENE---DKDIYIY----DSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVLLGRYNAAIFLSALVAIVFR---------------VSALSAGIALFSVIFKKISLFDAIKFGIFGLGLGSAISITVDSYFWQE---------------------------------------CLPEVDGFLFNVVAGYASKWGVEPVTAYFTHFMPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQKEWRFIIYAVPSIMLLGATGAAHLWE.......................................................................................................................................................................................................................................................................................................................................................... 353
21 -12.000[OKIT] KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator  ali follow..  10  4.SKPPRISLPFAAISRKSDFLLGASFSCIHVLLTTIVYHYVPEPYM---DEIFHITQTRSYCSGN----YSWNPLITTPP-----------ALYVISMPLCGGNERYANSILLFFAIPAFCRFRRMFVRVRIPTLKIYLKLQQDVWLTASIVGMLPILISSSILFYTD---------LLSLTSVIWGFSIGNPIASAFLFLISILTRQTWAAIYAFSVIASRIENLKIIISTAFSLWPFITLAIGFAMFIYFNDFQIVLGDAKAHQPKFHVAQFFYMVAFCAAHTWTQIIPNLLSHLRHLTDMKSLVLQAVVAVLVYYYSYDHPYLLADNRHFTFYIWRRFLANPTMRVFSLRFMTTSTPSVHIFHKILFIIASLLVLVPAHLFEMRYYIIPYVLWRLSTVNNSRKSLLFLEIISQAVIFAANEFVQ........................................................................................................................................................................................................................................................................................................................................................... 422
22 -11.700[S] COG3274 Uncharacterized protein conserved in bacteria  ali follow..  8  16.............................................................................................CIMVVMIHSTTYYVTRGAQVGELNWDIANVLNSASCVPLFF-----------MISGYLFFGEKSAQKKHFMRIG----LCLLFYSVIALIYISTLTPIDGWASLRNILQKPVFYHLW----FFYAIIVVYLVSPLIKVKPVSGRYLAILILLLAVVANPQTSKFSLDDFRLLPANLYIYGDTFYYLLYALLGRAMGMLETQGRMISWGAALLFVVSVICIAISTEKQTRINGSFADTFYMYCSPLVFIAAVSLWVWFKN-----CLNQHIAWLSGLARHSLAIYGF-------HALIIHFIRTHHYDFTAYPVLDILYVFALTLGLSTLLSMGLQRI........................................................................................................................................................................................................................................................................................................................................................ 323
23 -11.300[S] COG4713 Predicted membrane protein  ali follow..  8  1MNKRVVKV-----------EYIFMAFALFFGVLFAVIN-------FQDPDEPIHFYRAYQISTGQMFE-ATIYSDIVYIPQSIGINLAKIFRASALYMM-------------------YFGRIANLICWTIIVFFSVKLIPFKKNLM--AFLALTPMNLY--QAASLSADAMTNSMAFLSIALVLRYAFGEEEAKLTKRQIVTMIIAFTLLAFSKRIYFVMCILFFIIPIKKFNSKKDYIGTFVIMLGACLMSLVTVSVISKILAIKVITYIHILLRTFHFKMSFYAISFIGVFGWLDTRLPLNLYLFYGVALVLIALFEHTLIEKNKDRIIMFIVFIINVGLIMSALYVSWTPKAA-GRYFIPIIPLLGCFIGVKANKSRNVYSKVVLAISTFTILTYSVLQLLLRFYGIRI......................................................................................................................................................................................................................................................................................................................................................................... 455
24 -10.700[P] KOG4505 Na+/H+ antiporter  ali follow..  8  1MAWSQVEISKP-----HLAYAIIGGFTSLFMLCSLIIK--------------LFLGEATMATATGLIFGPYVAKLFVPTSWGNTDYITEELARVLLVVEVFAAGAELPRAYSMFVMLLPVMIFGWLVSTGFMYALIPRLSFLESLAIAACITATDPVLASSIVGK---NDGMAIPFLYLAIYLIIEKPARHAGRDWVCIIILYECTFGCVLG-------AIIGVIARKMIKFSERRGLMDRESFLVFYFVLALFC-------GGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEESHVSNVIDLLLNLSFFVYVGAIMPWPQLVVLAICILIARRIPAVLLFKSFVPDIINWREALFAGHFGPIGVGALYTCLVARAELEVHSTVPEPNDA-IENPEIPNWYCIQVMWPVVCFLVLSSIIVHGSSIAFFMLGKRINTLALSFTRTRDSHFAFNLPRVRQGQSLPIKRVDALRSSANSIASSIRRRHPVNIQEDEDADISTVSLPEAAHLREERAESPRGGHYDAEEFPSEDYESRQPRRSNEEDREEEMNPGDETYLIGEDLVVEDSQGNIISHTSSRDANGPSIDEKLAQGDPKAKSFGRKFRSFLRRSYDTFQRNLHEPDDERQREPTLGHIESSIENHRPRYSRQNSESHLRENSVERRRRE------------------------------------QVLTNIGDSESEDDNIPRPGIVPFYNENNESSSDTRNGLLSDNVSESRSRRPSRAPSAAVSSEGSPVEEDNE 742
25 -10.700[S] COG3463 Predicted membrane protein  ali follow..  9  9.....................LLVIIFIAYTFIIFKTCLVLYENFYKSLDLGIFSQSLYSTLNGKFMYNTVEAQLYS----APNHFAVHFQPILLLLLPVYAIMPS--------VVLLLIQAIFLALSATLALLIACEELNHREAILVASLYIFNSSLLGIALFEFHP-----VSLAVPLFFIAYMLLKRGKMKLFYLTSV---LILLTKEDSFLGVVSLSLWKILMDGLNPESFRKNRGLILLSIASMMYGIIVIKVVIPHLGMGYIYESLYSEFELTRRKLLYFIVFNASFGFLTFLSSKGLVSVALPWLESML--------------------------------SSRDTQTMIGFHYPYMLLPLSYLVAIEGFKKSKKVAVSLIVAGILTSMATIPITSWEAITIVKTLEGPIYTQPEFYPHLS.......................................................................................................................................................................................................................................................................................................................................................... 389
26 -10.200[P] COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain  ali follow..  14  36MRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLHHESNISWMFIVDILQQFGLGIVIGLGGGYLLLQLYPLLALSGGILIFSLTTALEGS--GILAVYLCGFLLGNRPIRNRYGILQDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALILSAWMISWVGLR---GAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLL......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 336
27 -9.990[S] COG0398 Uncharacterized conserved protein  ali follow..  9  1MMKMQSRKIWYYRITLIILLFAMLLAWALLPGVHEFINRSVAAFAAVDQQ-----GIERFIQSYGALA----------------------AVVSFLLMILQAIAAPLPAFLITFANASLFGAFWGGSLAALCFFIARVMGREVVGKHTILVCRLLPFV-----------------FDPISYAAGLTSIRFRSFFIATGLGQLPATIVYSWAGSMLLFILFALTVVIFMAKKIWLER.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 230
28 -9.990[G] KOG3893 Mannosyltransferase  ali follow..  11  435.......................AFLLLLLGLLMRLVIWHDRRSALKFTDDYFVFSDASKYVSIGMSPY----DTYRYTPM--------------------LAILLLPTQYGFPSWGKYLFSISDLIAGWLMIKLLSRRISYKRSLIYSSFWILNPFVAIISTRGNCE--AILGILSIALLYLIEKK-------SVWLASLILGFSVHF------IYPFMYGIAFLVYFSKPKKGSTFMEKFLSLLSINQLKIVVGSLFMFTICNLLMYYLYGSPFLEHTYLYHFGRTDHRHNFSLHHLNLYYESSFGAKASSLFAFLPQLSLCMLIPLVFGKKNLPGTLFAQTFAFVTFNKVCTSQY------FMWYLVFLPLVLPNSKLLSKKGLICLSLWIIGQLMLGKSVFIPLWLSGLLFFFFNVYELKIILDSL........................................................................................................................................................................................................................................................................................................................................................ 815
29 -9.960[T] KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit  ali follow..  9  94..DDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKD---YVQANPGWYWASYAVFFA---YLTLACCSGPRRHFPWNLIL----LTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVF-SFQTKFDFTSCQGVLFVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 316
30 -9.960[R] KOG2552 Major facilitator superfamily permease - Cdc91p  ali follow..  9  1MKEEKKDDGVMAEEKPY------FWIWTLASTIFRLF-LSSRPEVSTPHTSLRRLAEGYWLKQSSLSPY----SMYHGSP--------------LLLSILGPLTVQSDKFVVAGSKGNRVIICADLLSALLLRAIGQKLQKSYCGDIAALVYLWNPFTILSCVGL--STSPIENLAVIVSLYGAVTR-------RVPLAAFGLIMAT-----HLSLYSAPLVFPLIFLLGYGLDAPPIKKFLQTRHGGEKLTPTTQLPFSWRTVLHFVFWVLVWSSYVLVLCSLSLKQYGGLEEMFKRTYGFILRIEDLSPNIGVFWYFFAEAFEFSRNYLLIIFNLYILLTSIPSLMFRLKHRPSILKSYPSVGDAALYLSLWALFVNELTDMEYSFFIFCGYIGFSLLSTGNANFYFGNAMGYACFQFMFVEKSVNAMLNHDQALKKATAEMTKN....................................................................................................................................................................................................................................................................................................................................... 474
31 -9.530[GE] KOG2575 Glucosyltransferase - Alg6p  ali follow..  8  24.GSSIDTWWWLTHKGTTTSFLCISLFALLIRSAVTMYPYSGAGIPPKFGD-FEAQRHWMEITTN--LPVIDWYDLTYWYP--------PLTAYQSYIHGSVALLSSRGHESYLGKLLMRWTVLSSDAFIFFPAALNRTRGGKSEVAWHIAMILLNPCLI-----GHFQYNCISLGLTVGAIAAVLCE-------SEVLTCVLFSLALSHKQMSAYFAPAFFSHLLGKCLRRKSPILSVIKLGIAVIVTFVIFWDFLMVLSRLAPFERGIYEDYVANFWCTTSILIKWKNLFTTQSLKSISLAATILASLPSMVQQIL-----------------------------------------SPSNEGFLYGLLNSSMAFYLFSFQVHEKSILMPFLSATLLALKLPDHFSHLTYYALFSMF.................................................................................................................................................................................................................................................................................................................................................................... 414
32 -9.280[G] COG3936 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation  ali follow..  10  1MPTLTFKLIFSYRIFIYLLVFVLFPILLFYNSSLLGVKSYN--------HEFLSKKSTDCI------------------------------GLSILVIILHHISLRMQPVGFMGIYTCL------GHLAVSMFL-----------FFSGYGLMVSKLKKKNYFKGFFSKRLSKVYFVIINAITIILTSLIFGTKFNLKDIIFYLSGLSQW----FVIAILVFYLCFYVCFKFLSTNLAQHILLFLTFVYFFAMIF--------------MGFREWWYNTAFCFPLGVYAAINYDALTKFLEKHYVKTLIIALIAFTFFFFLAHMLPSAIMPLYQTIASIIFVYLVLLFLFKFRLSSKPLLFLGNIAYEIYLVHMKILVAFFSFARGSYIVYLYLILVIIVAFCFNKLFNLNKNKKVKLT................................................................................................................................................................................................................................................................................................................................................................... 356
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.