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Query: [I] KOG2304 3-hydroxyacyl-CoA dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLSSTCTAAVRGLSTTAQLSKINNVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQGIANSLKRVAKKKHADDAAAQTALVSSVLDRIKMSTNVSDSVKDADLVIEAIVENIDIKRKLFAEVEVAAKPTTLITTNTSSLRLADIGLNLKDKSRFGGLHFFNPVPMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTVACKDTPGFIVNRLLVPYMFEALRLYERGDASMEDIDVAMKLGAGYPMGPFELSDYVGLDTCKFIMDGWHAQYPEEVAFTPSPLLNSLVDSGKNGRKSGEGFYKYKLast
1 -112.000[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali  100  1MLSSTCTAAVRGLSTTAQLSKINNVTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAQQGIANSLKRVAKKKHADDAAAQTALVSSVLDRIKMSTNVSDSVKDADLVIEAIVENIDIKRKLFAEVEVAAKPTTLITTNTSSLRLADIGLNLKDKSRFGGLHFFNPVPMMKLLEVVRHTETSDATFNQLVDYGKTVGKTTVACKDTPGFIVNRLLVPYMFEALRLYERGDASMEDIDVAMKLGAGYPMGPFELSDYVGLDTCKFIMDGWHAQYPEEVAFTPSPLLNSLVDSGKNGRKSGEGFYKYK 309
2 -102.000[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  41  2.....................IKTVGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAGLATINGNLARQVSSGKMSDEDR-----KRALSLIKGSGDIND-LAQADLVIEAVTEDETVKRKIYGQVCPVMRPDAILATNTSSLSITRLASATDRPERFMGIHFMNPVPVMKLVELVRGIATEEETFKAAKEFVAHLDKTVTVAEDFPAFIVNRILLPMINEAIYTLYEGVGTVDAIDTAMKLGANHPMGPLQLADFIGLDTCLSIMQVLHDGLAD-SKYRPCPLLVKYVEAGWLGRKSGRGFYDYR 282
3 -75.700[I] KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase  ali follow..  31  335FEGSTNAKKNK----YGKGLPVNEIAVVGAGFMGAGIANVTINKGIRTVLLDANQAGVERGQNHVATHLNRQLKRQKISKLER-----EKIYNHLVPTIDYSA-MKNADVVIEAVFEDLPLKHKVIRQIENVVGPNTIIASNTSALPIKDIAAASSRSDKVIGMHYFSPVEKMQLLEIITHDGTSKETLATAAQLGLKQGKLVVVVKDCPGFFVVRCLSPMMSEIVRLLQEG-VEPSELDKLTT-KFGFPVGAATLADEAGLDVAEHVARYLGTALGPRVHGGSVDLLSELVRAGHKGRKTSKGIFVYG 631
4 -32.600[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  11  40............IAMTHSTITMGAELKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKG-DMQPGIIDKFIDDIKPGAIV-THACTIPTTKFYKIFEEKHETLNVTSYHPGPEMKGQVYIAEGYASEEAINTLFELGQKARGNAYRLPELLGPVCDMCSALTAITYAGILSYRDSVTQVLGA--------PAGFAQMMAKESLEQITALMEK-VGIDKMEEHLDPGALLGTADSMNFGASADIPTVFEI. 341
5 -12.200[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  12  3......................QHIGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRHPLAPNVV----------------ISPNLSFTTDMKEAIHNAFMIVEGVTSAG---RPVAEQLKQITDLSVPFVITSKGIEQNTGLLLSEIMLEVLGDSVTPYLGYLSAKEVLNGSPCSVVVSAYDSQTLKQIHERVYPNTDIKGAALGGALKNVINAKAGLVTRGLHEMRKLAAIMDCKPETLNGLAGLGDLC------------------------VTCFSESSRNLRFGHLLAQG..... 267
6 -12.100[S] COG5495 Uncharacterized conserved protein  ali follow..  11  13.......................NIAILSTGRVGVALE----RADQVVVCSAVSHASRQWVQFRLPE----------------------------TSVASPPEVASSAELLLLAVPDCE---AGLMSGVAVTPRPGTIVAHTSWANGVGILAQLGKDGCIPLAIHFSGSDEDLSQCQLFGITKTDDVGYAIAQSLVLEMGGEPFCVVESVSPHVGNHIVTVLADALEVRRSALRGSELCENTLQRGQAGLTKLVARGDLDALAGHLVALMRIGPELAQAYRVNALRKTQRAHAPYDVVEALA....... 308
7 -11.800[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  12  5.......................KVAVYGAGNQGSRMAIEFAEAGHDVVLAEPARDMLDDAHWK------------------------VVEDAGVTVTDNDAEAASEAEIAVLFTPFG-KKTFEIAKNITNHLPEGAVI-ANTCTVSPVVLYYVLERELRIASMH--HGHYVIGGHSSSELDIATDEQISRCVELAESCGKVAYVVPADVSSAVADMGSLVTAVTLSGVLDYYYVGTQI...................................................................... 228
8 -11.800[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  17  1.....................METIGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAK------------------------------LKTVSGHAAVAKAADIIITMVPDTPQVADVLFGDASGLTRGKLVIDMSSIS---PIETKVFAGKINELGCDYLDPVS--SLTIMVGG---EEKAFERAKPVFEKMGKNITLVGPNGV-VANQIVVALVAEALVFASKAGADPARVRQALMGGLA............................................................. 211
9 -11.400[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  18  7.......................SIAILGAGRVGSSLARSAVAAGYEVKVAG--------------------------SGAVDKIALTAEILMPGAVPSTADQAVKDADIVFLAVP-------HKFRSVNPATLEGKIVIDTMNHWSTSEIIAEFFAGSTMVKS--FNHIGYHEIEQAIAYATDDVDAGAQVAQLIKSFGFVPLNIGA..................................................................................................... 178
10 -10.900[E] COG0287 Prephenate dehydrogenase  ali follow..  20  7.....................FERIALIGIGLIGSSIARDVRELGLARHVV---------ISTRSEDTLKRAEELALGTD----------------YTVSAAEAVKDADLVIVSVP--VGASESVAQQIAPYLKPSAIVVGSTKASVIAQMAPHMPENVHFIPGH---PLA--RWCIFTPLPGTDAAALERLKDFWRALGSRVDEMD...................................................................................................... 179
11 -10.900[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali follow..  11  7....NKLSALSGSIQKSFSPKLISVGIIGSGNWGTAIAKICGENAKAHPDIFHPQVHMWMYEEKIQHEGKECNLTEVFNTTHENVKYLKGIKSNVFANPDIRDVGSRSDILVWVLPHQF---VRICNQLKGCLKKDAVAISCIKGVSVTKDRVRLF----LSGANIASEVAQEKFCETTIGYLNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVAVAAGIID---------------GLELGDNTKSAVMRIGLLEMQKFGRMFFDCKPLTMSEESCGIADLITTLGGRNHKCAVAF.... 308
12 -10.800[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  13  4......................QKIGFIGAGKMGSALMQGTIKAGINIGASDVYEPFLKDLQAKLG----------------------------IRVSTDNAVIVRESDILILAV--KPQTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMPNIAATVSEASGIAPGKNATPEDLKAALEIFSAVGTAVQVPESLPAFIALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAGIRAAF........................................... 253
13 -10.800[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  9  33..HLSVTDTIPLPNSNSNATPPLRIAIIGFGNYGQFLAETLISQGHILFAHSRSD-----------------------------HSSAARRLGVSYFTDLHDLCERHPDVVLLCTS--ILSIENILKTLPFQRLRRNTLFVDVLSVKKTLLLQYLPEDFDILCTHMFGPLRFVYDKVRIGEERLRVSRCESFLEIFVREGCEMVEMS...................................................................................................... 221
14 -10.300[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  12  29.............ADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEA------------------------IAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPD--KQHSKVVADVMPLMKKDSAFGYSHGF-DITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATG............................................................................................................. 199
15 -10.200[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  14  2.......................KVTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKKGRIAIFEPGLAPLVKENYEA---------GRLQFSTDAQAGVAHGVIQFIAVAADLKYVLDVASTIGTYMDSPKVIVSNPEFLKEGAAVADCKRPERIVGIDTDDSGALELISELYEPFNRNHDRMLVMDIRSAELTKYA-----ANGMLATKI--SFMNEIANIAERLGADIEKVRQGI--GSDSRIGYHFIYSGCGY............................................... 264
16 -10.200[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  10  16......................ALIGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDK------------LNAGQCYIEHIPQAKIAKARASGFEATTDFSRVSECDALILCVPTDMSFVINTTDALKPYLRVGQVVSLESTTYPGTTLLPRVQEGGLVVGRDIYSP-ETRTIPKVIGG--HTPQCLEVGIALYEQAIDRVVPVSSTKAAEMTKLLIGLVNEMKIVADRMGIDIFEVVDAAATK---PFGFTPYYPGPGL............................................... 269
17 -10.100[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  15  2.......................QLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAG-------------------------EDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKK---GIHLLD-CGTSGGVWGRERGYCDGDAFARAEPIFATVAPGVAAAPRTPG.................................................................................................. 165
18 -10.000[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  10  1.....................MLKIGIVGCGFIGGQICRAIDGGEVSAELYALCD-----------------------SSESKALELAASLKTCKPSYMKIEELIRGVDLIIESASQNAVRF-----VPQALKAGCDVMILSVGALADEELRDTLFGLAKEHNCKLYFPSGAVVGIDGLNSASAAG........................................................................................................................... 138
19 -9.420[H] KOG1270 Methyltransferases  ali follow..  12  68.FIRDNLLKTIPNHQPGKPLLGMKILDVGCG--GGLLTEPLGRLGASVIGIDPVDENIK-------------TAQCHKSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASE-VVEHVIDLETFLQCCCQVLKPGGSLFITTINKTQLSYALGIVFSEQIAGTHFVSPETLESILE.................................................................................................................................... 236
20 -9.400[R] COG2910 Putative NADH-flavin reductase  ali follow..  14  1.....................MAKIALIGAGNAGSRILKELSDRGHQVTAIARNPEKIA------------------------ALPNVVAKKGDVFDQAALSELLKGHDAVISSVHFTASDPATLIEAVRASGVQRYLVVGGAGSLEIAPATKGAEFLDKLKQEKQLDWTFLSPSAEFVPGERTGKFRIGKDNLLSNEQGSR-ISFEDYAIALADEI............................................................................................ 189
21 -9.380[H] COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase  ali follow..  12  45....................GLAGKKVLDIGCGGGILSEAMAQRGASVTGIDMGEAPLAVARL----------------HQLESGVAVDYRQITAEQMAEEMPGQFDVVTCLE-MLEHVPDPASVIRACHRLVKPGGQVFLSTINRNPKAYLFAVIGAEYILGTHFIRPSELGAWSR.................................................................................................................................... 193
22 -9.210[MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases  ali follow..  13  17...KNALSTASEEPPMTLANLPPLVTVFGGGFVGRHVVRMLAKRGYRIRV------------------AVRRPDLAGFLQPLGNVGQISFAQANLRYRDSIIKAVEDADHVVNCVGILAESGRNTFDAVQEFGAKAIAEAARDTGATLTHISAVILRPSIIFGPE-FQPVYVEDVAEAVARSVDGKLKPGAIYELG---GPDVMTFRDCLEAVLAAT............................................................................................ 264
23 -9.080[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  9  1.....................MSKLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQAYKKEKQFEVKIQNEAHQHLEGKFEINRL--YKDVKNVKGEYETVVMACTAD--AYYDTLQQLSLETLQSVKHPTFGSQMIVEQFMSKFSQDIEVISFSTYLGDTRIVDKEYMGSTHSNSTMCQRISALAEQLKIQLEVVES..................................................................................................... 202
24 -9.030[C] COG0039 Malate/lactate dehydrogenases  ali follow..  11  7......................NKVVLIGNGAVGSSYAFSLVNQSIELVIIDLDTEKVRGDVMDLKHATPYSPTTVRVKAGE--------------------SDCHDADLVVDLVSKNLKIFKSIVGEVMASKFDGIFLATNPVDILAYATWKFSGLPKEIIGEHGDTELPVQPLKTLLEQRPEGKAQIEQIFVQTRDAAYDIIQAKGATYYGVAMGLARI----TEAIFRNEDAVLTVSALLEGEYDEEDVYIGVPAVINRNGIRNVVEIPLNDEEQSKFAHSAKTLKDIMAE............... 312
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;