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Query: [J] KOG2314 Translation initiation factor 3, subunit b (eIF-3b), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MAAVVDIDVLTAQLGINWSDVNLDSIQLPPGNDFGIESDDESVYQDDQSEFDTGFGNIIVVDHLPVVPKEKFEKLEGVVKKIYNQLGVIKENGLLMPVDPDTKMTLGYCFIEFNTPQEAQNAKEKSHGYKLDKSHIFAVNMFDDFDRLMNVKEEWEPPQERPYVPGPFEVLGLDTYMVFVFQENLQKWLTDDKARDQLVIRFGHDTEVYWNDARQKKPEPVHKRSYWTESYVQWSPIGTYLVTLHKQGAAVWGGADTFTRLMRYQHSMVKLVDFSPGEKYLVTYHSQEPSNPRDASKVEIKVFDVRTGRMMRDFKGSADEFSIGGPGGVAGASWPVFRWAGGKDDKYFAKLSKNTISVYETETFSLIDKKSMKVDNVVDICWSPTDSILSLFVPEQGGGNQPAKVALVQIPSKVELRQKNLFSVSDCKMYWQSSGEYLAVKVDRYTKTKKSTYSGFELFRIKERDIPIEVLELDNKNDKIIAFAWEPKGHRFAVIHGDQPRPDVSFYSMKTAQNTGRVSKLATLKAKQANALFWSPTGKYIILAGLKGFNGQLEFFNVDELETMATAEHFMATDIEWDPTGRYVATSVTTVHEMENGFTIWSFNGNMVYRILKDHFFQLAWRPRPASFLTAEKEEEIAKNLRNYSKRYEAEDQDVSLLLSEQDREKRRALNEEWQKWVMQWKSLHEEEKLVRQNLRDGEVSDVEEDEYEAKEVEFEDLIDVTEEIVQELMLast
1 -197.000[J] KOG2314 Translation initiation factor 3, subunit b (eIF-3b)  ali  100  1MAAVVDIDVLTAQLGINWSDVNLDSIQLPPGNDFGIESDDESVYQDDQSEFDTGFGNIIVVDHLPVVPKEKFEKLEGVVKKIYNQLGVIKENGLLMPVDPDTKMTLGYCFIEFNTPQEAQNAKEKSHGYKLDKSHIFAVNMFDDFDRLMNVKEEWEPPQERPYVPGPFEVLGLDTYMVFVFQENLQKWLTDDKARDQLVIRFGHDTEVYWNDARQKKPEPVHKRSYWTESYVQWSPIGTYLVTLHKQGAAVWGGADTFTRLMRYQHSMVKLVDFSPGEKYLVTYHSQEPSNPRDASKVEIKVFDVRTGRMMRDFKGSADEFSIGGPGGVAGASWPVFRWAGGKDDKYFAKLSKNTISVYETETFSLIDKKSMKVDNVVDICWSPTDSILSLFVPEQGGGNQPAKVALVQIPSKVELRQKNLFSVSDCKMYWQSSGEYLAVKVDRYTKTKKSTYSGFELFRIKERDIPIEVLELDNKNDKIIAFAWEPKGHRFAVIHGDQPRPDVSFYSMKTAQNTGRVSKLATLKAKQANALFWSPTGKYIILAGLKGFNGQLEFFNVDELETMATAEHFMATDIEWDPTGRYVATSVTTVHEMENGFTIWSFNGNMVYRILKDHFFQLAWRPRPASFLTAEKEEEIAKNLRNYSKRYEAEDQDVSLLLSEQDREKRRALNEEWQKWVMQWKSLHEEEKLVRQNLRDGEVSDVEEDEYEAKEVEFEDLIDVTEEIVQELM 730
2 -108.000[R] COG5354 Uncharacterized protein, contains Trp-Asp (WD) repeat  ali follow..  27  1..........................................................................................................................................................................................SWLMDDKVRDQFVLQDDVKTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQGVTAW-GGPNFDRLRRFYHPDVRNSSVSPNEKYLVTFSTEPIIVEKKNEGHQLCIWDIASGLLMATFPVIKSPYLKWP------------LVRWSYNDKYCARMVGDSLIVHATKNFMPLEAKALKPSGIRDFSFAPEGVKLQLAYWTPETNNSACTATIAEVPRGRVLKTVNLVQVSNVTLHWQNQAEFLCFNVERHTKSGKTQFSNLQICRLTERDIPVEKV---ELKDSVFEFGWEPHGNRFVTISVHEVADMYAPETKEKTDVIKRWSLVKEIPKTFANTVSWSPAGRFVVVGALVMRRSDLQFYDMDSLKDVAHPTYSAATNITWDPSGRYVTAWSSSLKKVEHGYKIFNIAGNLVKEDIIAGFKNFAWRPRPASILSNAERKKVRKNLREWSAQFEEQDAMEADTAMRDLILHQRELLKQWTEYREKIGQEMEKSMNFKIFDVQPEDASDDFTT---IEEIVEEVLEETKEKVE... 573
3 -102.000[J] KOG2315 Predicted translation initiation factor related to eIF-3a  ali follow..  16  26...............................................................................................................................................................................................APSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVNIISVTN-KGLLHSFDLLKAVCLEFSPKNTVLATWQPYSTSKDGTAGIPNLQLYDVKTGTCLKSFIQKKMQ---------------NWCPSWSEDETLCARNVNNEVHFFENNNFNTI-ANKLHLQKINDFVLSPGPQPYKVAVYVPGSKGAPSFVRLYQYPNHAALANKSFFKADKVTMLWNKKATAVLVIASTDVDKTGASYYGEQTLHYIATNGESA-VVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATIF--------NLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRRVNNGYKIWHYTGSILHKYDVAELWQVSWQPFLDGIFPAKTITYQAVPSEVPNEEPKVATAYRPPALRNKPITNSKLHEEEPDKKIKNLKKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI.... 609
4 -45.200[R] KOG4497 Uncharacterized conserved protein WDR8, contains WD repeats  ali follow..  11  3............................................................................................................................................................................................................................FSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADSLFILC---------AMYKRGLVQVWSLEQPEWHCKIDEGSAG---------------LVASCWSPDGRHILNTTHLRITVWSLCT-KSVSYIKYPKACLQGITFTRDGRYMALA----ERRDCKDYVSIFVCSDWQLLRHFDTDTQDLTGIEWAPNGCVLAVW---------DTCLEYKILLYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAVGSYDG---KVRILNHVTSLQTLKPVTDRANPKMGIGMLAFSPDSYFLATRN-DNIPNAVWVWDIQKLRLFAVLQLSPVRAFQWDPQQPRLAICTG-----GSRLYLWSPAGCMSVQVPGEGVLSLCWHLSGDSMALLSKDHFC............................................................................................. 439
5 -40.500[S] KOG0293 WD40 repeat-containing protein  ali follow..  8  1MGVVEDTEPPLKRAKR---LADEPNGFSANSSVRGSSVNSNSLGDLMARPLPSQGDDETIGSKGVIRKSEFVRIITRALYSLYDKTGAMLEEESGISLHNSTIKLFLQQVKD----DQSVKTLHRIGSFLLLEQKFLEFLKVEKIADALRTLRNEMAPLRINTKRVHELASSLISPSSFISHTTSTPGKESVNSRSKVLEELQTLLPASVIIPEKRLECLVENSLHIQRDSCVFHNTLDSDLSLYSDHCGKHQIPSQTAQILESHTDEVWFLQFSHNGKYLAS----------SSKDQTAIIWEISADGHISLKH------------TLVGHHKPVIAILWSPDDRQVLTCGEEVIRRWDVDSGDCVHMYEKGGISPISCGWYPDGQGII-------AGMTDRSICMWDLDGREKECWKGQRTQKVSDIAMTDDGKWLVSVCKDSVISLFDREATVERL--------------IEEEDMITSFSLSNDNKYILVNLLNQ---EIRLWNIEGDPKIVSRYKGHKRSRFIIRSCFGGYKQAFIASGS----DSQVYIWHRSTGKLIVELPGHAVNCVSWSPTNLHMLASASD----DGTIRIWGLDRQKKKLVQGSSSNGVIHRCNGN........................................................................................................ 589
6 -36.900[A] KOG1272 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  10  49...................................................................................................................................................................................................EGANLETLKDKKLKTQLASREKLYGKSAKAAAKIEKWLLPAEAGYLETEGLEKTWRVKQTDIANEVDILSSRNQYDIVLPDFGPYKLDFTASGRHMLAGGRKGHLALLDMMNMSLIKEIQVRE----------------TVRDVAFLHNDQFFAAAQKKYAYIYGRDGTEL--HCLKERGPVARLRFLKNHFLLA-------SVNMSGQLHYQDVTHGGMVASIRTGKGRTDVMEVNPYNSVVGLGHSGGT------------VTMWKPTSQAPLVQMQCHPGPVSSVAFHPNGHLMATSGKE---RKIKIWDLRKF------EEVQTIHSFHAKTLSFSQKGLLAAGTG-----SFVQILGDSSGGSSHNYKGYQIEKVMFRPYEDVIGIGHS-----MGWSSILI-SGEPNFDWVANPFETSKQRREKESLLDKLPPETIMRKEKPSRGEIEAEKEVAIEAAKSTELKNKTKGRNKPSKRTKKKKEMVENAKRTFPEQEH-NTAIKKRRIVEDAAAELPTSLKRFARK..... 547
7 -35.400[B] KOG0273 Beta-transducin family (WD-40 repeat) protein  ali follow..  12  169.......................................................................................................................................................................................................................PNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQNKDVTSLDWNSDGTLLAM----------GSYDGFARIWTE-NGNLASTLGQHKG---------------PIFALKWNKKGNYVLSAGDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFAS--------CSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT------------LKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSMLASASFDSTVRLWDVEQG----VCTHTLMKHQEPVYSVAFSPDGKYLASGS---FDKYVHIWNTQSGSLVHSYQTGGIFEVCWNARGDKVGASAS-----DGSVCVLDL............................................................................................................................... 522
8 -34.900[A] KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  11  363...................................................................................................................................................................................................DWVALASREIGQLLVWEWQSEQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSTSGVTGIQFSRNKKFLVS----------SSLDGTVRAFDVNRYRNFRTFTSPNPAQ--------------FSCVAVDYSGELVVAGGQDDIFLWSVKTGKLLEIISGHEGPVVSIAFSPVATSSTLVS-----GSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSGEEIAVATLSGNITIFDIKSAGQVTTIEGRNTDIITARKNAQANYFSTIEYSADGECILAAGKS---ANICIYHVREAILLKKFEHSLDGLNDFISRKHLSEFGNMALVEEREELEGGIRLPGVQRGDMSSRRFQQEVFSVKFSPTGQAFAAAGT-----EGLCIYALDKGVVFFDLSLEVTPKAVHESLKQQNYTKALVMSLK-EPNLIALVLERVPYKDVELVCADLSPEFAQRLLQQLARQLQSTPHIE-KHGNQDGVFQHTGLLALHEVLSRKYEMLNKICDYNKYTLKVLL 894
9 -34.700[T] KOG4378 Nuclear protein COP1  ali follow..  11  1............................................................................................................................................................................................................................................................................MMSNLVEPSWRLLAA-----------SGGDTVKLFDVSADSGDPCVLSYTPSPGC-----------AVNSVKWNHTNLVVASTGEDKISLWRKNGQSLKDGGDSAEECLSAISFSKKGSRYIC------SGGTGQIVKIWDLQRKLCIKKLKGHTSTITGVMYNCKDEHLASVSVGGDLIVHNLASGARATELKDPNGQ-----VVQFVHVLRLLDYSRSSRHLLVTAGDDGT--VHLWDTTGR---SPKMSWLKQHSAPTAGVCFSPSNEKIIASV--GMDKKLYTYDSGSRRSSSCIAYEAFSSLAFGDNGYILVAGTS-----NGRVVFYDIRGKLHAFSNSEDVTSLSWQTSKPVIVNEKNYTSEMALLGSTVEDSVVIPDPLPSTTPS..................................................................... 363
10 -33.900[S] KOG0296 Angio-associated migratory cell protein (contains WD40 repeats)  ali follow..  13  26........................................................................................................................................................................................................................................KLMDQGVTEDEAEQEQNDTMNNMVMDMSVQGFFKDSVFSVSINPVHSNLCA---------SGGGDDLGYIWDITTGEQICQLTGHKDS---------------IVAIDWSFDGTYIATGGDSQVRLWKSSTGFEFITAFETVDEIVWLSWHPKGLFLA-------AGCNDGSIWMWSLPSGKVVQVMYGHTAPVNAGKFIPPGKRLATVDDSGTLIVWNPATGAPECRMSSDDHRFDP-GNEETAAGWTSFDCNAEGNVLFLGGSSG---KVKVVNINSS----HILASLEAQTESVEAIALCTALPICACAS---VDGTVALYDSASLKFRKSLPHEQVIDCKFLPNTPYLLTACA-----DCVIRKWDVSGQLLYTGHQEPILCMAITPDGKRVVTGSDDTELL............................................................................................ 393
11 -33.900[R] KOG0289 mRNA splicing factor  ali follow..  10  1......................................................MSLICSISN-PCVSPVSNHVYERLIEKYIAENGTDPINNQPLSEEQVAHPIRPKPPSATSIPAILKALQDEWDAVML---HSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPLVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKIL---------TGGADKNVVVFDKSSEQILATLKGHTK---------------KVTSVVFHPSQDLVFSASDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLL-------SSSDDQYWAFSDIQTGRVLTKVTDSGCSLTCAQFHPDGLIFGTGTMDSQ------------IKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADD---SSVKLWDLRKL---KNFKTLQLDNNFEVKSLIFDQSGTYLALGG---TDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGM-----DRSLKFYSL............................................................................................................................... 504
12 -33.700[Z] KOG0318 WD40 repeat stress protein/actin interacting protein  ali follow..  12  20..............................................................................................................................................................................................................................RTQRGQPIVLGADPKGKNFLYTNGNSVIIRNIENPAIADVYTEHSCVNVAKYSPSGFYIAS----------GDASGKIRIWDTVNKEHLLKNEFQPIAG-------------PIKDISWSPDNQRIVAVGEGRGHVFMSETGTSVGEISGQSKSINSADFRPARPFRIV------TGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGKFFASAGFDGKVFLYDGTSSELV----------GEFGSPAHKGGVYALAWKPDSTQLLTCSGD---KTCRLWTVESR---ELVSEFVMGTTVDDQQVSCLWQGDNLITVSLSGVITYLNVADPSKPLRVVKGHNKPITVLGLSDDRSTIYTGSH-----DGVVTNWNSGSGTNDRITGHGNQINGIAAWGDFVYTCGIDDSLR............................................................................................ 391
13 -33.600[A] KOG0647 mRNA export protein (contains WD40 repeats)  ali follow..  9  2.......................................................................................................................................................................................................................................SFFNRSNTTSALGTSTAMANEKDLANDIVINSPAEDSISDIAFSPQQDFMFS---------ASSWDGKVRIWDVQNGVPQGRAQHESSS--------------PVLCTRWSNDGTKVASGGDNALKLYDIAS-GQTQQIGMHSAPIKVLRFPSNTECIV-------TGSWDKTIKYWDMRQPQPVSTVMM-PERVYSMDNKQSLLVVATAERHIA------------IINLANPTTIFKATTSPLKWQTRCVACYNEADGYAIGSGMQKKSGFSFKCHRQTNPNRAPGSNGQSLVYPVNSIAFHPLYGTFVTAG---GDGTFNFWDKNQRHRLKGYPQASIPVCSFNRNGSVFAYALS-----YDWHQGHMNRPDYPNVIRLHATTDEEVKEKKKR....................................................................................................... 365
14 -33.600[S] KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains  ali follow..  9  132...............................................................................................................................................................................................................................RGRDCRNNLYLLPTGETVYFIASV-VVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAV-----------TCIAFSKSNGGTNLCAVDDSNLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGEITTGDSSGNILVWGKGTNRISYAQGAHEGGISPLCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTITQGHTDELWGLAIHASKPQFLTCGHD---KHATLWDAVGHR-----PVWDKIIEDPAQSSGFHPSGSVVAV---GTLTGRWFVFDTETKDLVTVHTNEQLSVMRYSPDGNFLAIGSH-----DNCIYIYGVSDNGRCSGHSSFITHLDWSVNSQFLVSNSGDYEIL............................................................................................ 599
15 -33.300[S] KOG0271 Notchless-like WD40 repeat-containing protein  ali follow..  12  84............................................................................................................................................................................................................QPQAVFRVRPVTRCSASIPGHGEPVISAQFSPDGRGLASGSGDQTMRIWDIELELPLHTCKKSWVLCIAWSPDATKIAS----------ACKNGEICIWNAKTGEQIGKTLKRHKQWITSLAWQPMHK---------DPTCRLLASCGDGNIFIWDTVQGTVVRCLSGHTASVTCLRWGGEGLIYS--------GSQDRTVKMWRADDGVMCRNMTGHAHWINTLALNTDYALRTSCFEPSKRCIKPDTVEECQKVA---------------QTRYEAALEIAGGERLVSGSDDF---TLFMWNPKET---KQSINRMTGHMQLVNQVVFSPDTRYIASASF---DKSVKLWCGRTGKYLASLRGHVVYQVAWSADSRLLVSGSA-----DSTLKVFELKTKSLYYDHGDEVFTVDWSPEGTKVVSGGKDKVLK............................................................................................ 469
16 -33.300[R] KOG1273 WD40 repeat protein  ali follow..  11  22................................................................................................................................................................................................................................EHGVIKCVAFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRSAAITSVSWSKYGHRLLV----------SAADKSLTLWDVSTGEKIARTILQQTGLSSPSLCLACPLSSAPMIVDFDIDCTTLLPVSVPEMPDVLAPPQRSKCPESNPPFSPAAACFNKCGDLVYI-------GNSKGEILIVDYKSVRVLALVSASGAAPVKIVFSRNGQYLLTNSHDRTIRIYENLLPAKNKMKTVGSKCLTLFREFQTKMHWKAPCFSGDGEWVVGGSACKGEHKIYIWDR-----AGHLVKILEGPKEALIDLAWHPVHPIIVSVS---LAGLVYIWAKDYTENWSAFAPDFEENEEYVEREDEFDLIPE-----TEKVKVLDVNEDEIDTVEKDAFSDSDMSVEELRYLPAEPIPDTNDQQDNLVESIKLIEGQISASPASEEAGQNGHHASSPQAGKKDSNSVI............................................. 474
17 -33.200[S] KOG0282 mRNA splicing factor  ali follow..  11  1MSAAIAA--------AASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEVAVKEDLTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLL---------SCSMDCKIKLWEVYGERRCLR--------------TFIGHSKAVRDICFNTAGTQFLSAADRYLKLWDTETGQCISRFTNR-KVPYCVKFNPDEDKQNLFV----AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAE-----------PSMHSMPAVTLSPNGKWLACQSMDN---QILIFGAQNRFRLNKKKIFKHMVAGYACQVDFSPDMSYVIS---GDGNGKLNIWDWKTTKLYSRFKAHDCIGAVWHPETSKVITCGW-----DGLIKLWD................................................................................................................................ 579
18 -33.100[S] KOG1407 WD40 repeat protein  ali follow..  17  16.............................................................................................................................................................................................................................YQGHKKKVHSVAWNSNGTKLASGSVDQARIWNIEPHGHSKAKDHTDSVDQLCWDPKHSDLVA---------TASGDKSVRLWDARSGKCTQQVELSGE---------------------------------------------------------NINITYKPDGTHVAV-------GNRDDELTILDVRKFKPLHRRK-FNYEVNEIAWNMPGDFFFLTTGLGT------------VEVLSYPSLKPLDTLTAHTAGCYCIAIDPKGRYFAVGSADS---LVSLWDIS----DMLCLRTFTKLEWPVRTISFNYSGEYIASAS----DLFIDIANVQTGRTVHQIPRAAMNSVEWNPKYNLLAYAGDDKNTDEGVFRIFGFESS............................................................................................................................ 315
19 -33.100[DO] KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits  ali follow..  11  53...................................................................................................................................................................................................DEVTSASRKAYMTQLAVVMNQNRTRILAFRNKPKSLLSTNHSDSPHQNPKPVKPRRYIPQNSERVLDAPGLRDLNLLDWGSANVLAIA------------LGDTVYLWDASSGSTSELVTIDEDKG-------------PVTSINWTQDGLDLAVLDNSEVQLWDCVSNRQVRTLRGG-HESRVGSLAWDNHILT-------TGGMDGKIVNNDVRIRSSVETYLGHTEEVCGLKWSESGNKQASGGNDNVVHIWDRSLASSK------QTRQWLHRFEEHTAAVRALAWCPFQASLLATGGGVGDGKIKFWNTHTGACLNSVE-----TGSQVCSLLWSQSERELLSSH-GFTQNQLTLWKYPSMSKMAELNGHTVLFMAQSPNGCTVASAAG-----DENLRLWNVFGEPPKTKAASKKYPELFSHVNS........................................................................................................ 442
20 -32.800[A] KOG0265 U5 snRNP-specific protein-like factor and related proteins  ali follow..  10  6.....................................................................................................................................................................................................................PNNSVILAQEAKRSKNDLMAYTNRDKALLESGVRRTSNLQAP----MQLEGHEGEIFTAEFHPEGELLLS----------SGFDRQIYIWQVYEDCENVM--------------AMSGHSGAVMEAHFTPDGSHIFTCSDKTLAFWDIATGQRQRRFKGHGNFVNSVQGSRRGQQLLC------SGSDDRTIKIWDARKKHAAHTLE-SPFQVTAVCFGDTGEQVISGGIDNE------------VKIWDIRKQAVLHHLRGHSDTITGMSLSPEGDFILTNAMD---NTLRVWDVRPYAPGERCVKVFQGHQHNFERCAWSPGSDKITSGS---ADRHVYIWDVNTRRILYKLPGHNVNAVDFSPKEPLILSGSS-----DKTLYLGEID.............................................................................................................................. 346
21 -32.500[R] KOG2055 WD40 repeat protein  ali follow..  10  1.............MEKDTEELELENAVFGNINNFSSFLDKENETFDVMMNEAPELSE----------NDAQEDELEKLEDAELSVPLDIIAGDNTVKEDEEASNEIPSIWEDSDDERLMISLQDHSRLRKLRQYEDEDMVNGLQYARRLRTQFERVYPVPEWAKKQDVTEEEDEFNALSEKSVIPKSLKSLFKSSVSYINQSSKLLAPGTINIKRLKDANFQAPSHSGIRCMSIHPYFPLLLTCGFDRLRIYQLDGKVNPLVTLRSSALQTALFHPDGKRVIA----------AGRRKYMYIWDLESAQVQKVSRMYGQEN----------FQPSMERFHVDPTGKYIALEGSGHINLLHALTGQFATSFKIE-GVLSDVLFTSDGSEMLVL-------SYGAEVWHFNVEQRSVVRRWQVQDGVSTTFCLDPSNKYLAIGSKSGIVNIYDLQTSNA------DAAPKPVTTLDNITFSINSMSFSQDSQVLAI-ASRGKKDTLRLVHVPSFSVFRN--PTSATPLGRVTCLAFGKGGELCV----GNEAGRVGLWKLAHYDLKFVPDKIINWEIRLGKFGYVLLGIQILILHVDVVI.................................................................................................................................... 555
22 -32.500[JT] KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)  ali follow..  11  2.........................................................................................................................................................................................................................KPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMTGAVWCVDADWDTKHVLT----------GSADNSCRLWDCETGKQLALLKTNSA---------------------------------------------------------VRTCGFDFGGNIIMFST--DKQMGYQCFVSFFDLDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGE------------LNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKD---NTAKLFDSTTLEHQKTFR-----TERPVNSAALSPNYDHVVLGGGQEAKFEARFFHLAFEEEFGRVKGHFINSVAFHPDGKSYSSGGE-----DGYVRIHYFDPQYFEFE....................................................................................................................... 322
23 -32.300[A] KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats)  ali follow..  9  61............................................................................................................................................................................................................................SLDGHRDGVNCLAKHPEKATVLSGACDGEVRIWNLTQRNCIRTIQEGFVRGICTRFCGTSFFT----------VGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGID-----------HHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLL------GSCASDRNIVLYDMRQATPLKKVI-LDMRTNTICWNPMEAFIFTAANEDY----------NLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFD---KSIRIFPVDKS---RSREVYHTKRMQHVICVKWTSDSKYIMCGS----EMNIRLWKANASEKLGVLTSREKEKFQHYPHIKRIARHR------HLPKSIYSQIQEMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK........................................................................................ 445
24 -31.800[R] KOG0286 G-protein beta subunit  ali follow..  12  2....................................................................................................................................................................................................................GEMEQLRQEAEQLKKQIADARKACADVTLAELVSG-LEVVGRVQMRTRRTLRGHLAIYAMHWATDSKLLVS----------ASQDGKLIVWDSYTTNKVHAIPLRSSW---------------VMTCAYAPSGNFVACGGDNMCSIYNLKSREGNVKVSRELSALSCCRFLDDNNIVT--------SSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDAS------------AKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDD---ASCRLFDLRADQELICFSH--ESIICGITSVAFSLSGRLLFAGY----DFNCNVWDSMKSERVGILSGHDVSCLGVTADGMAVATGSW-----DSFLKIWN................................................................................................................................ 340
25 -31.700[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  8  110.EEKDSKSKQTDDKPSGSGAASKKALTAELPKRDSSKPEYQDSDTSDEEDIRNTVGNIPMWDAKKIIKPPQGDQIDEFLRKI-GQDVRLTDEDIALIKRIVSGRIPNKDHEEYEP--TSEVEKMPIKNVPDHKRSFLSVSEKKRVSRMVHALKMGWMKTTEEVEREKQAKRRRIHDPVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLKDEPHKRKLYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDMVYRGHTDLVRSVSVEPKGEYLVS----------GSDDKTVKIWEIATGRCIRTIETDE----------------VVRCVAWCPNPKSIIAVATGNRLLLVNPKVGDKVLVKKTDDLLAEAPSQDVIESER-------IKTAVQWSNAEADEQEKGVRVVITHFKPIRQVTWHGRGDYLATVMPEGA---------NRSALIHQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVATQH----NIRIYDLVKQ----ELVKKLLTNSKWISGMSIHPKGDNLLVSTY---DKKMLWFDLDLSTKTMRLHRNAVRSVAFHLRYPLFASGSD-----DQAVIVSHGM----EKRDEFGVLDVNWHPVQPWVFSTGADSTIR............................................................................................ 781
26 -31.600[A] KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  10  161..................................................................................................................................................................................................HEKLVVGYIEGQLNLYNRGAPKKLVNTWKSHNSHITALLQVPDSRVVVALSRDQTMSIHETETQETLRVLPYESIEGGAIGHNGNLFLAYDVVSNRFLAISAEQNLIILDFENLKIARQIVGFHDEI--------------YSCCLLGKDESHMAVASNTSIRLYNTKTLDCQLIRGHTESVLSVVSPTWDTSLLA-------SCSKDNSIIFWRLVTSPEVAAATGHANTVTALAISNTGRAPFLASVSTDCTIKEVKIDAEKDFVEQLPKLTCSSTMVAHGKDVNCVDISESDALIATGGMD---KLVKLWQVDTHKMQLGIAGTLSGHRRGVGDVKFAKNSHKLASCS---GDMTIKIWNISEKSCLQTISSCAVFRVIFARNDSQLISADS-----AGIIKIWTIKTADSIDAHTDKIWSLSKNHNESEFVTAGTDGRIKDVTEEKQKAEDNKRREAIEQDQTLTNLLSQKRYSEALVFALTLAKPFCAFKVINALMAEETPEELGSAIRRLDTRQIEILLQFTVK...... 721
27 -31.400[ABO] KOG1446 Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2  ali follow..  11  1......................................................................................................................................................................................................................................................MKIKLIDSVVRSFKVAKINTDKINAIDFAPNGEHLIS----------CSEDDQIVIYDCEKGTQSRTVNSKKYG---------------VDLIHFTHANNTAIHSSDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFL-------SGSLDKTLRLWDLRSPNCQGLMHLSGRP--IAAYDPEGLIFAAGVNSESIKLYDLRSF-------DKGPFVTFKLNQEKECDWTGLKFSRDGKTILISTNGS---VIRLVDAFHGTPLQTFT--YPNNKGIPIEASFSPDSQFIFSGS----DGRVHIWNADTGNKVSVLNGDHVQCVQFNPKYMMLASACT-----NMAFWLPTSE.............................................................................................................................. 314
28 -31.400[A] KOG0285 Pleiotropic regulator 1  ali follow..  12  51.......................................................................................................................................................................................................IQVAFGGVEPASKPTRIADHNSEKTAPLKALALPGPKGSKELRKSATEKALVVGPTLPPRDLNNTGNPGSTAILPAPGSFSEVAFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQ---------------VRGLAVSNRHTYMFSAGDKQVKCWDLEQNKVIRSYHGHLHGVYCLALHPTLDVVL-------TGGRDSVCRVWDIRTKMQIFVLP-HDSDVFSVLARPTDPQVITGSHDST------------IKFWDLRYGKSMATITNHKKTVRAMALHPKENDFVSASADNIKK---------LPKGEFCHNMLSLQRDIINAVAVNEDGVMVT----GGDKGGLWFWDWKSGHNFQRAEEAGIYAACYDQTGSRLVTCEG-----DKTIKMWK-----EDEDATPETHPLNFKPPKEIRR..................................................................................................... 476
29 -31.100[S] KOG0295 WD40 repeat-containing protein  ali follow..  13  33..................................................................................................................................................................................................KESSLSENDIKPLGGILEKKWTTVLRLQRKVNDLESKLQESQREINHGAPTRDKRQAADWIPRPPETQKLTRLPITRVIFHPLWTIMAS----------CSEDATIKVWDYETGQLERTLKGHTDA---------------VNDIAIDAAGKQLVSCSSDSIKLWDGQTYDCLKSLKGHEHTVSSVTFLPTGDFVL-------SASRDHTIKQWDISTGYCVYTFRGHNDWVRMIRISNDGTLFASASLDQT------------VTVWSFATKSAKLVLRDHEHAVECVEWAPDTAYTNILFSGSRDRSIKAWNINTG----DVLFTLLAHENWVRGLAFHPKGKYLISVADDK---TLRVWELSAQRCMKAIEAHEVSTVAFHQTSPFVITGSV-----DMSCKVWECR.............................................................................................................................. 404
30 -31.000[A] KOG0284 Polyadenylation factor I complex, subunit PFS2  ali follow..  12  82........................................................................................................................................................................................................................CENRLWQYGKQRILQQPDILYQQYAVPADSTPDVPVDCILTKFIRTAMNKVKVYSVCWSPEGKRLIT----------GCQTGEFTLWNGTAFNFETILQAHDS---------------AIRALKWASNEQWLLSADGGYVKYWQPNMNNAHMFSAHKDEAIRGLAFAPTDVKFA-------TASDDGTARVWDFARYTEERVLRGHGAEVRCIDWHPTKGLIATGSRD----------TQQPVKIWDPKSGSCLATLQEHKSSVMAVEFNKNGNWLLTGGRD---HLVKMYDIRMM----KEMRTYRAHKKEVISLAWHPIHEGLFVSG--GGDGSIVYWMVDGEKEIGLLHDQAIWSMKWHPLGHILATGSN-----DNNTKFWARNRPTNMIGHLDKEREPRMAPPKPSIETQETYRPDT............................................................................................ 465
31 -30.900[BK] KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily  ali follow..  9  189.......................................................GRFALADNKIKLYSGERTGKFTSVCELKGHTDWIRSLDFSLPLHTTEEIPNSIMLVSSSQDKVIRIWKLVLVGDVGSWRREITLASYIEGPVFVSGTFTYQ---ISVESVLIGHEDWVYSVEWQPPVIDFIDGRLVNHQPLSILSASMDKTMMIWRPEKKTVCVGELSHCALGFYGGHWSPNSLSILAHGYGGFHLWRNVSSSKESENWQFAAVTDVTWARTGEYLLSVS----------QDQTTRVFSAWKNDEGNE--AEDEHWHELARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVRVFEAPLSFLKTLNHTSFPEDLQADVQVLGANMSALGLSQKLKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMAE-------IWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTDNGEVSHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDK---TVKIWSVENDARIKQILGSSVTAVAWTGLDRNEKSGCVAVGMESGLIELSNVKIIEPFMCHVSAVNRLAWRPTEKCLTSCGDDNCVR............................................................................................ 834
32 -30.700[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  10  399......................................................................................................................................................................................................LTFPPSSGKSFIMGADEALESELGPGELAGLTVANEADSLTYDIANNKDALRKTWNP---KFTLRSHFDGIRALAFHPIEPVLIT----------ASEDHTLKMWNLQKTAPAKKSTSLDVE----PIYTFRAHKGPVLCVVMSSNGEQCYSGGDGLIQGWNTTNPNIDPYDSYHTDAVWGLAYSAAHQRLL-------SCSADGTLRLWNTTEVAPALSIKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTA-----NSSCQINRVISHPTLSISITAHED---RHIKFYDNNTG----KLIHSMVAHLEAVTSLAVDPNGLYLMSGS----DCSIRLWNLESKTCIQEFTAHSIHDVAFHPSKCYIASAGA-----DALAKVF................................................................................................................................. 779
33 -30.700[U] KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p  ali follow..  10  2....................................................................................................................................................................................................................ASNQQPPSNLQTYGVPIYAVDWILEEAVRSKITKDQDDDDDDGSSSSSYIVLSGGGGEGRSGIPNVILICRVDLHTNSLSEQP------------------------------IGRRVIGTDLPYRMAIHPRQGGLICALPNSCRLFDEEESEKVVKELKDVGQQLSLSFNQDGTVLAT-------GAEDGTLRVFEWPSMKTLLNESKTHASVKSLTFSESGKFLVSLGAP------------LCRVWDVNASAAIASLSKEKDEMFASCRFSVDNSGLYVAANTQRGGSIITWDTTSW---RRRSSKLIKRNNSISAFNVSADGKLLAVGT---LEGDVLIIDSTKMQIVKKAHLGLVTALTFSPDSRCLVSVSF-----DSRARLTVIKQKRVYLWVAALLFVLVYVVLYYLMVAMGIIH............................................................................................... 383
34 -30.500[R] KOG1524 WD40 repeat-containing protein CHE-2  ali follow..  9  2.....................................................................................................................................................................................................................KLKLSASRKTRHTEMVCGVGWIGTEAILSAADDHVFLLTNTNESQQILNMPETFFPTSLHIFPRS---QTKGGQNDVFAVSTSDGKINILS-RNGKVENMVDAHNG---------------AALCARWNSDGTGLLSSGDGFVKMWSRSG-MLRSVLAQFATAVYCVAWDSTSSNVLYCNADH--------CYIKSLKMQVAPIKWKAHDGIILCCDWNPTSDLIVTGGEDLKFKVWDGF-------------GQILFNSSVHDYPITSISWNTDGTLFAV----GSHNILRLCDK-----SGWSHSLEKMNAGSVMALSWSPDGTQLAVGT---AAGLVFHAHIIDKRLTPTMIEYNERTVNIIVQCEKIFLVSD-----GMTITIFTYEGRKLINLNPPGQRKIDLANDTLVVRDRADNKVLHKAQGDGNLKHEHDIVELTVNQCGPLNDRNVAFRDQ--------IGAVHIAMVKTFGVSQRMVKIGSLVEQLVFNDVTNMLCGISEGKI.... 527
35 -30.500[A] KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  9  404......................................................................................................................................................................................................................VRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIW-NRSTLQCIRTMTCEYALCSFFVPGDRQVVI----------GTKTGKLQLYDLASGNLLETIDAHDG---------------ALWSMSLSPDQRGFVTGGDKSVKFWDFELVKDENSTQKRLEDVLCVSYSPNQKLLAV-------SLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRN------------VKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKD---HKIKQWDADKF----EHIQTLEGHHQEIWCLAVSPSGDYVVSSS---HDKSLRLWERTREPLILEEEREMEREAEYEESDQPAVPGET-----QGDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKV 888
36 -30.400[R] KOG2096 WD40 repeat protein  ali follow..  10  10....................................................................................................................................................................................................ASVILGALIAVLFFGSYFRKRTSEVQSMAKAEPQDPIRNPKSNHPAPKKNHPKSQASDKNQNKRHHPLHGDAVTGLCFSSDGKSLAT----------ACADGVIRVFKLDDASSKSFNRWEFTLQAHFHDLTVFFVCFLPTAVAFADDASSIVVACHHMSIKWDHHHIHEKRSVLTISGATATYGTADGSVVIA-------SCSEGTDIVLWHGKTGRNLGHVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIVYQKD-----SVKEVSRVMQLKGHKSAVTWLCFSPNSEQIITASKD---GSIRVWNINVRYHLDEDPKTLKVNPLHYDRLSLCPEGKILAASH----GSTLQWLCAETGNVLDTAHEGDITCISWAPKAMVLGTSGD-----DKKVKLWEAKSQSL.......................................................................................................................... 454
37 -30.300[D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily  ali follow..  9  5.............................................................................................................................................................................................................................................................TPSAGRELSNPPSDGISNLRFSNNSDHLLV----------SSWDKRVRLYDVSTNSLKGEFLHGG----------------AVLDCCFHDDFSGFSVGADYKVRRIVFNVGKEDIFDFSILFFYTLCLFCDVTGQVI-------TGSWDKTVKCWDPRGASGPERTQVYLQPERVYSMSLVGHRLVVATAGRHVN----------IYDLRNMSQPEQRRESSLKYQTRCVRCYPNGTGYAL---SSVEGRVAMEFFDLSEAAQAKKYAFKCHRKPVNSIAFHPIYGTFATGG---CDGFVNIWDGNNKKRLYQYSKYPISALSFSRDGQLLAVASSYKSQEPEAIFVRSVNEIEVKPK....................................................................................................................... 345
38 -30.100[K] KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)  ali follow..  10  8..................QPQDLNRIVLDYLAKKGYSRTEAMLRLEASGSGVSVEEKLKSIEETPDAYTHTYTILRDWVDSSLELY-KAELHRILFPI---------HSYLNLLSQDHYEAAKQFYELFKHTDLHDFDVKNLKSLSLPSHVAED--------RTAQQYRQNKYQLHFSRITFDLLLHFLFENVSNGGSIIGDAQLQPVKLQQMPMDKEMEKIVEMDLEEEDMMHQNDPNNQSPKLLKEFRKLHEPNAEDAPSRDPLPPHKGVDILSEVEAVAEFSPDSTMIACGFQESYIRLWSIKADKKSLPKSTSVEDSDG--SVRLLSHSGPVYGTTFSPDNKYLLSCSDASARLWSVDTKTALVAYKGHTGPVWDVAFGPFGHYFA-------TASHDQTAQLWSCDHIYPLRVFAGHLSDVDCVTFHPNSAYVLTGSSDKT------------CRLWDVHRGHSVRVFNGHTQPVTAVAIAPDGHTMASADSE---GLIHLWDIGTG----RRIKTMRGHRGNIYSLSFSRESTVLVSGG---SDCTVRAWDVFKTNYNNPVSSSGSVVTPFSAKTSTFNEVNWSTSP----------DQMVALYTKQTPIFNVSFTRRNLCLAISVS................................................................................................. 643
39 -30.000[R] KOG1334 WD40 repeat protein  ali follow..  9  4LKAAICADDLIVMVVASLILATQNPDSVQPFGYCSGAKKLSDVRILWRTIGASEVKL-------PYRDKNDHQHLSGATRKLLLPGVPDQLQQTSFEMSHQEGSTGG-SLFSSPEEQSGVAAVTAASSDIEMAATEPSTGDGGDTRDGGFLNDASTENQNTDSESSSEDVELESMGEGLFGYPLPRMCPRCGGTNHDQCLLDEDQAL----EEWISSETSALPRSRWQVLTALRQRQLGSSARFVYEACGARTFVQRFRLQYLLGSHAVSTIHFNQRGTRLAS----------SGDDLRVIVWDWVRQKPVLNFESGHDIN--------------VIQAKFFPNCGLAMCGHDGQVRVAELINASYCENTKRHRGPAHELALEPDSPYKFL------TSGEDAVVFTIDLRQDRPVTRENDKKVGLYTISMNPANIYQFAVGGHDQFVRDQRRIDKKENNGVLKKFTPHHLVYCDFPTNITCVVYSHDGTELLASYNDE---DIYLFNSSLSDGAQYVKRYKGHNDTIKCVNFYGPRSEFVVSGS----CGHVFFWEKSSSQIIQFMRGDIVNCLEPHPYLPVLATSG-----LDQHVRIWTPTAKTALTGLKDVIKKNKQERDEDNLNYTDSFDNRM............................................................................................ 628
40 -29.800[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  12  430.....................................................................................................................................................................................................................PTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDLIGPGIPRHARQINTLNHGEVCAVTISNPTRHVYT-----------GGKGCVKVWDISHPGNKSPVSQLD----------CLNRDNYIRSCKLLPDGCTLIVGGASTLSIWDLAAPTPRIKAELSAPACYALAISPDSKVCF-------SCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQL-------------QQHDFTSQIFSLGYCPTGEWLAVGMES---SNVEVLHVNKPD-----KYQLHLHESCVLSLKFAYCGKWFVSTGKDNL---LNAWRTPYGASIFQSKESSVLSCDISVDDKYIVTGSG-----DKKATVYEVI.............................................................................................................................. 769
41 -29.700[Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC  ali follow..  12  2...........................................................................................................................................................................................................................SLHQFLLEPITCHAWNRDRTQIALSPNNHVHIYKKNGSQWVKAHEHNGHITGIDWAPKSDRIVT----------CGADRNAYVWSQKDGVWKPTLVILRINR-------------AATFVKWSPLENKFAVGSGALISVCYFEAENSKHIKKPIRSTVLSLDWHPNNVLLA-------AGSCDFKCRVFSAYIKESEFGGSGTGGWVHGVSFSASGSRLAWVSHDST------------VSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDC----CPMLFIYDDR----GCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRAT------TEDRNTALETLHQNSITQVSIKQDCRKFCTTGI-----DGAMTIWDFKT............................................................................................................................. 359
42 -29.500[U] KOG1332 Vesicle coat complex COPII, subunit SEC13  ali follow..  13  6..................................................................................................................................................................................................................................................................NTVDTSHEDMIHDAQMDYYGTRLATCS----------SDRSVKIFDVRNGGQILIADLRGHEG-------------PVWQVAWAHPMYLASCSYDRKVIIWREENWEKSHEHAGHDSSVNSVCWAPHDYGLILAC-----GSSDGAISLLTYTGEGQKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL-STIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSG---GDNKVTLWKESVISDVNKGQGSVSASVTEGQQNE.................................................................................................................................................... 321
43 -29.400[R] KOG2394 WD40 protein DMR-N9  ali follow..  8  147...................................................................................................................................................................................................TYLVFNVSDAIFICDLNSQEKDPVKSIHFSNSNPMCHAFAKDGHDLLIGLNSGVYTVSLRQQLQDVSK-RQDRCTSISWVPGGDGAFVATESTFPAIRDPTQFSVDKAKYSKSNPVARWHICQG---------------SINSIAFSNDGAHLATVGDGYLRIFDFLTQKLVCGGKSYYGALLCCSWSMDGKYIL-------TGGEDDLVQVWSMEDRKVVAWGEGHNSWVSGVAFDSNWSSPNSDGSGEHVMYRGSVGQDTQLLLWDLEMDEIVVPLRRAPGGSPTYSTGSSAHWDNVIPMGTLQPAPCKRDVPKL----SPIIAHRVHTEPLSGLMFTQES--VVTAC----EGHIKIWTRPSESETQTNSSTALLSTSFTKDNKASLSSKI-----ISGSTFKQ................................................................................................................................ 556
44 -29.300[R] KOG0315 G-protein beta subunit-like protein (contains WD40 repeats)  ali follow..  11  3..........................................................................................................................................................................................................................................DQQQLILATGGYDHTIKVWQAHTGNCIKTMETSQVNALDRTPDKTRLAA-----------CGYQCIRLYDLESNCTAPVINFDGVQK-------------NVTRLGFQEDGNWMFTAGDHHVRIWDMIAAPPHCSRIFCEAPVNAACLHPNQVEIAM-------GSQNGSVFLWDVKSERHERIVPEVDASIQDVAISPDGRYLAAANNKGNCYIWSLTSQDQ-----KMSTLRPNRKIPAHSRYILRCKFSPDSRLLLTTSGDG---TVCIWKTD----DFSKWRELCIENYWVWDAAFSADSKWLFTAS---SDGIARLWKLQTKSSIRDYTGHTITALSFKDEIPVKSTNIS-----DVQSSAKPPT---QRDNPPGTNNLAFFETVGRVAMNPYMGNTTT............................................................................................ 359
45 -29.300[BL] KOG1009 Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats)  ali follow..  9  12................................................................................................................................................................................................................................NKEPVYSLDFQHGTARLASAGVDTVRIWKGKAIVEFLSNLARHTVNVVRFSPTGEILAS----------GGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENLRGHLEDVYDICWATDGNLMASASDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQYVA-------TLSCDRVLRVYSIQKKRVAFNVS-MKSFFRRLSFTPDGSLLLTPAGCVESGENVM---NTTYVFSRKNLKRPIAHLPCPGKATLAVRCCPVYFELR-------------------------------VVETGVELMSLPYRLVFAVASEDS----VLLYDTQQSFYVSNIHYHTLSDISWSSDGAFLAISST-----DGYCSFVTFEDELGIPLKEKPVLNMRTPDTAKKTKSQTHRGSSPPRPVEGTPASRTQDPSSPGTTPPQARQAPAPTVIRDPPSITPAVKSPLPGPSEEKTLQPSSQNTKAHPSRRVTLNTLQAWSKTTPRRINLTP 504
46 -29.300[R] KOG0645 WD40 repeat protein  ali follow..  11  4.........................................................................................................................................................................................................................................................................TGRLWSVAAHPMLPLFAT----------SSQDKSVRIYNSNTYNLVHVIDGFHTR--------------SIRRVAWRPIERLAVASFDSVVSINEDDDWECTAALEGHENEVKCIAWSCNGNYLA-------TCSRDKSVWIWEATEDDELAVLQEHTQDVKVVTWHPTEDLLVSGSYDNSICFWRD----------DGDDWALTCQLQGHTNTVWALAFSPNGNTLASADND---GNVFLWIKISSNEDKQQTSLPHIHKGAVYTISWMNDATLCSAGG----DGKIVVYQREKHDEALAHGVYEINSLEYLRDDR-LLSGGD-----DGECRVWSFK.............................................................................................................................. 322
47 -29.200[S] KOG0321 WD40 repeat-containing protein L2DTL  ali follow..  10  78.....................................................................................................................................................................................................................PAQLCKELLIRQLGGSRSHPFSTKTSRHVGGRLNLETYYSRPSE---CLMMLNQLPFCLGFANNESLLAV----------CTETGALELFDSRFYDRQNEENQPSAR----RIHGWLAHNNAIFSVNFSKDDSLLATSSGDTSKVFDLSTQQCITRLG-HSHSVKQVNFCNDSPYNLV------SCSRDGSIIFWDMRTHGITIENSGRDCSITSATWLPQSTSQVISSCSANSALKLWDLRTVHTVRPLPAATTPELTTSKRDFGVTNVCTSPDGERIYAASRD---SIIYEYSSRHLNSGKTYKDPRLRISSFYVKLACSPDGATLACGGVQDKTSGVVVFDTTRNCMLTGGHTKDVTAVDWSSEGQ-LASISD-----DGSVRVWNSSLANLREKNFSEIFYWGFSEK.......................................................................................................... 490
48 -29.100[R] KOG2321 WD40 repeat protein  ali follow..  10  5............................................................................................................................................................................................................................VQNPNNVRVYTVSGEGVTQRLPNWISKRKLKKDYSHRIELLQDFEYPESNRIKCTRDGKYAMA---------TGVYKPHIKVFDFAEMSLKFERHTDAENVQ---------------FEILSDDWTKSVHLQTDRVDFHSQGGIHYSTRIP---KYGRDLKYHYPNCDLYLA-------AAGDEVYRLNLEQGRFLNPLKIPTGGVNVIDINPMHQLLAFGTDAGSVEFWDPRDRSRVGIL-EIPSTVPSTPYSDNSRSVTALKYRNDGLNVAIGLSDG---ATLLYDLRSS---SPYMSKDQGYSMPIKSLHWMDSALDGTARVLSADSKIIKIWEKDTGKPFSSIEPTVLNDVCPIEGTGLILTANE-----GSPMHAFYIPSPRWCSFLDNITEEMEENPDDYKFVTKKELLNLGGVIRAYNNLYEKARLIANPFSYEEHRQKIKERLEKQRASKIRSQNRPKVNAGLASRLSYQENKLRKKTGVILEDERFKNVFTDKEFEVDE.. 507
49 -29.100[U] KOG0277 Peroxisomal targeting signal type 2 receptor  ali follow..  9  2...................................................................................................................................................................................................................SAVCGGAARMLRTPGRHGYAAEFSPLPGRLACATAQTLLILDPDEAGLRLFRSFNDGLFDVTWSENNEHVLI---------TCSGDGSLQLWDTAKAA-------------------------------------------------------GPLQVYKEHAQEVYSVDWSQTRGEQLVVS-----GSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGD-----------QTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVD--CSLRGWDLRNV---RQPVFELLGHTYAIRRVKFSPFHASVLASC--SYDFTVRFWNFSKPDSLLETHTEFTCGLDFSLQSPTQVADCSW----DETIKIYDPA.............................................................................................................................. 317
50 -28.700[S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat  ali follow..  9  29.....................................................................................................................................................................................................................SNAPRTEEPTHVPQSVSVSSKSESGVSSSAVSDDEDDFMPDLPPGFQMQQSEAGPSSSRAEGPEDSDDSD----------FDETEAISIIKLIPAACEAKISHGTQ---------------AISALRVEPPGVRFASGGDYYVKLFDFQKMDMSMRYDKELHVINSLAFSPNGETLVVA-------SGEAIIRLLDRAGKQDLNITKGHTATVNCVEFNPLNKNEFISCSDDGSLRLWNLDDHKVITINKHRKVIKTKGANGKRVSPQVCTFSPDGKWIAAGCDDG---SVQAWKYGSQYVNVNYL-VRKAHNGSITSIAFSPDSKRLLSRGFD---DTLKMWSLDNPKEPLLVNAFKSTDCGFSPRAEVVFTGTSSPNDTPGTLQFFDPMTFDLVYKPGISCHRIQWHPRLNQIIAGLSDGTIH---------YDQTMSQRGVMSCVTKPLKRNRASEVVREDMVLSPLSLEMFQPRGEEGEEKEVTGWRIKKYLRMQDNKLRPEFRKPADMPIN. 527
51 -28.400[R] KOG0288 WD40 repeat protein TipD  ali follow..  11  174...................................................................................................................................................................................................................NEANDLYEEMLAKLKANGLETLARQQVDGIVRRNEDGDHFVESTIPSTCANRIHEGGCGSIVFEYNSGTLFT----------GGQDRAVKMWDTNSGTLIKSLYGSLGN---------------ILDMAVTHDNKSVIAATSNNLFVWDVSSGRVRHTLTGHTDKVCAVDVSKFSSRHVV------SAAYDRTIKLWDLHKGYCTNTVL-FTSNCNAICLSIDGLTVFSGHMDGN------------LRLWDIQTGKLLSEVAGHSSAVTSVSLSRNGNRILTSGRDN---VHNVFDTRTLEICGTLRASGNRLASNWSRSCISPDDDYVAAGS---ADGSVHVWSLSKGNIVSILKEQTILCCSWSGIGKPLASADK-----NGYVCTWT................................................................................................................................ 515
52 -28.300[S] KOG0316 Conserved WD40 repeat-containing protein  ali follow..  11  1........................................................................................................................................................................................................................................................MSATELPTKEAHILKGHEGAVLAARFNGDGNYALT----------CGKDRTIRLWNPHRGILIKTYKSHGRE---------------VRDVHVTSDNAKFCSCGDRQVYYWDVSTGRVIRKFRGHDGEVNAVKFNDSSSVVV-------SAGFDRSLRVWDCRSHSVEPVQIIDTFLDTVMSVVLTKTEIIGGSVDGTVRTFDMRIGREMSDN--------------LGQPVNCISISNDGNCVLAGCLD---STLRLLDRTTGELLQVYK---HISKSFKTDCCLTNSDAHVIGGS----DGLVFFWDLVDAKVLSKFRHDLVNSIDVDFYLRLLKFFVA---GDKRELPPEGLYVDFFGR........................................................................................................................ 308
53 -28.200[R] COG2319 FOG: WD40 repeat  ali follow..  9  80.................................................................................................................TSRNGLDRFIPMTSNKDTISLGRHSSLSRNLVNKTKNASETYQQLLEYALEVERDDNVFTYAKLQKSDMTQKCPTMVASEKDNKGKLNEKKNRSPEN-LLPFRILDAPELRDDFYTSLLSWSPKGDLAIGLAEN-IYLWSKELGPTRVLEESIYDVSSVAYSYNGDILAV----------GRVDGTLQFWQDNERVPRISIHHPG---------------------------------------------------------DIGVLAWKPVLETNRLLV-----GKGNGNIFVYDIKAVLVATITNAHDEQVCGLTWNHDGSQFASGGNDNR------------VCLFKGSDLRQPLYVWQQNAAVKALSFCPWQRSLLATGAGSHDKHIRFYNCFNGKKIDELY-----CGAQITSIHWSPKYREFSVTSLETVQHRFAVYSWPQLECLVSVPDIRCVHSVLTSQTDSIIIASS-----NETIKFFDLSEESSWHNHGIFDSQILEMLEG---IDGKIDSHLR............................................................................................ 535
54 -28.100[T] COG5170 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  7  1.....................................................................................................................................................................................................MDDIEDSLDQWKFAQCFGDKGDVEDITEADIISAVEFDHTGDYLATGDKGGRVVLFERNHSKKGCEYKEEKINKIRWCKRTN--------RAHFLLSTNDKTIKLWKLYEKNLKVVAENNLSDSFHSPMQG-------------PLTTPSQLRLPRLNHHDMIIAAYPRRVYANAHAYHINSISVNSDAETYISA--------DDLRINLWNLSISDHSENMEELTEVITSAEFHPINCNHLMYSSSKGDLRQSALCDNPCKLFEDQEDQDSKSFFSEIISSISDVKFSQNGRYILS----RDYLTLKIWDVNMEKAPVKTIPLHDVLRSKLCECTFSGDDKHVLSGSYSN---NFGIYPTDSSLPGDRGQNKKILHASWHPFEDSVAIAAT------NNLFVFS................................................................................................................................ 461
55 -28.100[T] KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit  ali follow..  9  1......................................................................................................................................................................................................MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGESTFQSHEPEFDYLIRWLPQKNQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYR----------------DPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYL--------SADDLRINLWHLEITDRSFNIVDIKPANMEAEFHPNSCNTFVYSSSKGDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMM----TRDYLSVKIWDLNMENRPVETYQVHEYLRSDKFECCWNGSDSVVMTGSY---NNFFRMFDRNTKRDITLEASREILHTAWHPKENIIAVAT------TNNLYIFQDKVN............................................................................................................................ 447
56 -28.000[S] KOG2110 Uncharacterized conserved protein, contains WD40 repeats  ali follow..  10  2...................................................................................................................................................................................................................................HFFVRKYRGKAALLSIGTFDGYKIYNCDPFGKCFHKIQGASIVEMLFSTSLVALVE--------KDDGNNRKLKLINTKKSTTICELTFPT----------------PLLAVKLNRKRLLAV--LEEQIYVYDISNMLLLHTIETTSNVFAVCALSPNSENCYLAYPDSRDSAVSGQVILWDVINCKQITKIEAHKDSLACLAFNSDGTMLATASDNGR-----------IIRVFAIPSGQRLYQFRSLPAQIYSIAFHPDSSLLTVTSSTQ---TVHIFRLKEV----YSNLERQGLLPSSPPPKESLLRRSSRSLIGTVGG---MLDPERDFAYAHIPGDKVTSIAAFGPDNTIVNVATY-----DGNLYSFRVNLR............................................................................................................................ 355
57 -28.000[DK] KOG0973 Histone transcription regulator HIRA, WD repeat superfamily  ali follow..  13  11............................................................................................................................................................................................................................................................................ILAIDCHPSGKKFIT-----CGQKARTSNGLVVVWNAEPVLD----KKKASNENVPKLLFQVESQSQSNSCRWSPDGKRFAFGSDDSVSVWEVERYKECCVLRGHSMEVLTVEWSPNGKYLA-------SGSIDYRIIIYNARKPDRITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSV------TEPFESNIEETMLTRLDWSPDGKYLMTPAARSGKPLIKLIQRQT-----KSDQFLAGHHKGTTCVRAMPRLTCAAVGSRDK---SISIWVFPGTLLFVINNIFNHTVMDFAWCGRNLLACSQ-----DGTVKVIHLSGEMISNEAMSDLCYQIYSIRPPRYELTDKEEDESQDSFNLSDLSSSANNASFVTCPEDVLIKRKKLVAAQQSSDIQLTKSMEDNSKENESKNSEKTMMEERNKQIDVRKDGKRRIQPV........ 469
58 -27.900[R] KOG0646 WD40 repeat protein  ali follow..  10  7...................................................................................................................................................................................................................................................................................................ASSSIDEGIGSWDLKTGTEQLQFKPCASPAHGLTAVG-----------KFLASSQLSARNTSGSIFYWSWTK-PQAEVKSYPVEPIKALAANNEGTYLV-------GGGISGDIYLWEVATGKLLKKWHGHYRSVTCLVFSGDDSLLVSGSQDGSIRVWSLIRLFDDFQ-RQQGNTLYEHNFNEHTMSVTDIVIDYGGCNAVIISSSEDR-TCKVWSLSRGKLLKNII------PSVINALALDPGGCVFYAGA---RDSKIYIGAINATSEYGSEKGKAITCLAYCADGNLLISGSE-----DGVVCVWDPKSLRHVRTLIHAKGSRK-NSNKTQVSWKSRGALIPPPLEKYERPVEDTMDGIVTVDPPPFSDVPVYSSFLSADLIDEQVKELQQQGSAATEMEMERLKLEYKRSLQMNEQWQKNYENLLQVVMEEEQ 433
59 -27.800[S] KOG4328 WD40 protein  ali follow..  10  2...............................................................ATEYERKRLENIRR--DEMLAALNVRAKASSLLSAAKRSRDDSKSFKKKKPKPASTPTVIRMSLRTR-DGFSDFRMGSQITHNQPSPQKQSPRLLAPIPFESAYEGYGSYTQLVDTLLGIESKSCRGKLVKGEIGVVKDENESPMVRTRSSSRVSKVSVKKEEPEDDSFSDYVNKEFSIPVKPEKIEFDLDLLTLEPVARVVPGRIFVVQFLPCENVKMV--------AAGDKLGNVGFWNLDCGN----------EEDNDGIYLFTPHSAPVSSIVFQQNSRVISSSYDGLIRLMDVEK-SVFDLVYSTDEAIFSLSQRPNDEQSLYF------GQDYGVFNVWDLRAGKSVFHWELHERRINSIDFNPQNPHVMATSSTD--------GTACLWDLRSGAKKPKTLSTVNHSRAVHSAYFSPSGLSLATTSLDN---YIGVLSGANFENTCMIYHNNTSRWISKFKAVWGWDDSYIYV---GNLSKKIDVINPKLKRTVMELHNPLQRAIHCHPNVGTLAGSTA-----GGQVYVWTTK.............................................................................................................................. 516
60 -27.800[S] KOG0308 Conserved WD40 repeat-containing protein  ali follow..  7  1.....................................................................................................................................................................................................MSSCVNTSQTGPKKKISFIIRDEHEYSNRSAVSALQYDAQNGRLFTGGSDTIIRTWSVPHHKDAFSARTDWVNDMILCGHGKILLAYAPIVEKAVSASFDHNIFVYDINANFKTVN--------------NLIGCKDSIYSLATTPNLSLVLGAGEKCIRLFDPRTNEKIMKLRGHTDNVRALVVNDDGTRAL-------SAGSDATIRLWDIGQQRCIATCIAHEEGVWTLQVDSSFTTVY------------SAGKDKMVVKTPLYDFTKSQLLFKEEAPVKKLLLSEKDNPVSLWVGTWKS-DIKRWSIRPS----AQLSIGGDEDGPSTSNANHSVSASSSPPVTFKYIRVKDQKGQQSTPELVIPGAPAIKKHAMLSDKRHVLTRDS-----DGNVALYDVLGKRIFEEVVDENSRQVYIPSWFVVDSKSGMLQITLDELDALSSWLSSKDAGFDDNDRETKQIIVNYGGMMLRSLFERWPPCKMTNVDAADADDVQKAT............................ 527
61 -27.600[A] KOG0640 mRNA cleavage stimulating factor complex; subunit 1  ali follow..  11  45...................................................................................................................................................................................................DQCAPSERLLHVMIAGMQTLSDKDKTNSDDVLPGIDLEFEPEASALAPEPHSYETAYVTSHK---------QACRAGAFSCDGSLVAT----------GSVDASIKILDVERMLAKSAPEDIEPGREQQGIRTLYDHTDEVSYLEFHPKEHILASASDGTVKLFDIAKPSVKKAHKVDCEPVLCLSFHPTGDYVAI-------GTEHNVLRVYDVATTQCFVSSQQHKAGVTCVKYSPTGKLYATGSYDGDIKIWDGISGRCINTIAEAHGG----------AAICSLEFTRNGKYLLSSGMDS---LVYLWELCTSIQTYTGAGTTGKQEHQTEAVFNHTEDYVLFPDE---ATTSLCSWNSRNGCRLTLNHNGPVRYITHSPNGPAFLTCSD-----DFRARFWYRRA............................................................................................................................. 421
62 -27.600[S] KOG0310 Conserved WD40 repeat-containing protein  ali follow..  8  38...................................................................................................................................................................................................KPYHVATTSSVRLTLYDTVVCEPLNLFSRFKKGVCSIDFRHDGRLLAIGGDEGVRIFDVEKTTGRVMQASQSTVKSVHFSPRGDTVFS----------MADDGKIKQYRVADTAYGVN-------AVPIIEIQAHEDAIRCGAVSSINDHIVLTGGYDHKVRLWDIRSKEKSLELD-CEHPVESVLFLPGEQLIA--------TAAGPIVKIWDTTTGRQLTALQAHYKTVTSLRLATNSTCLLSAGIDRRVNAFRTTNYSLINSW-------------SMPSPVLDIDVSRDDQTMAIGMGNL---LALYRRAEIK----KEATASAAIEDKRSLIRTSAPPVKLVEKDRDMQKVDVVAKNADKLKI--PKIDGMLSNFKHAAVIKLLFGGKFRSAMDTAVVSYLRLAGQSVQKNILVFLNHNLYKAQYFSTLKEV----VNAFFDVYALEKLDKDVVKHVQSLRGSLGRELEVQKMISSLIGSIDLIVSTTKMNVKSSSTALIEDNDVFGEPTIRARDLDELKPSDQGAEEE. 539
63 -27.500[R] KOG1539 WD repeat protein  ali follow..  9  201...................................................................................................................................................................................................DVVAIGCADGKIHVHNIKLDEEIVTFEHASRGAVTALSFSTDGRPLLASGGSFISIWNKKRLQSVIRDAHDSSIISLNFLANEPVLMSFYSNGRHILSAGQDRAFRLFSVIQEQQSRELSQRHISRRAKKCNVVTCHMDTAEAYVWRLQNFVLGEHILKPCPENPTPIKGVFVSRNHLLLAILACAISACGNFAVV-------GTAGGWIERFNLQSGISRGSRYAHDGEVIGVACDSTNTLMISAGYHGDLKVWDFKKR-------------ELKSQWDVGCSLVKIVYHRVNGLLATVADDF---VIRLYDVVTL----KMVREFRGHTDRITDLCFSEDGKWVISSS---MDGSLRIWDVILAKQIDGVHVDVITALSLSPNMDVLATAHSD----QNGVYLWVNQSMVESYASGKDVVNVKLPSVSALTSSEADDDMDRKQIPELVTLSLLPKSQWQSLINLDIIKARNKPIEPPKKFLPSIPSLSGDILFKANDSEADGENEENNKKDQNSMKNFDALESPFSKHLKSS. 805
64 -27.300[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  9  2............................................................................................................................................................................................................................SLCGHTSPVDSVAFNSEEVLVLAGASSGVIKLWDLEESKMVRAFTRSNCSAVEFHPFGEFLAS----------GSSDTNLRVWDTRKKGCIQTYKGHTRG---------------ISTIEFSPDGRWVVSGGDNVVKVWDLTAGKLLHEFKCHEGPIRSLDFHPLEFLLA-------TGSADRTVKFWDLETFELIGTTRPEATGVRAIAFHPDGQTLFC-------------GLDDGLKVYSWEPVICRDGVDMGWSTL-GDFCINEGKFIGCSYYR---NSVGIWVSDISELEPYGAVSEDKNECMVKRFSVLNDQSERMGSG-------------PRGSVSPDYETREIKNIYVDSTGGNLNVAQN-----PGSLKATLLESGKVATMVSEKQNAAYFGPAGDKYSSTSRDSDSGEESSYSERESIPFSRTKSGMLLRPAHVRKTLAKFEESKQSAVVQSATRKKSGLAVEEEPQTQNFLSEQNASKPFDAEDSIIKGITNKFEKAL 449
65 -27.200[T] KOG0279 G protein beta subunit-like protein  ali follow..  12  2....................................................................................................................................................................................................................AEGLVLKGTMCAHTDMVTAIATPVDNSDVIVTSSRDIILWKLTKEDKSYGVAQRRFVQDVVLSSDGQFALS----------GSWDGELRLWDLATGESTRRFVGHTKD---------------VLSVAFSTDNRQIVSASDRTIKLWNTLGECKYTISEAHKEWVSCVRFSPNTLVPTIVS-----ASWDKTVKVWNLQNCKLRNTLAGHSGYLNTVAVSPDGSLCASGGKDGVILLWDLAEGKKLYSL-------------EAGSIIHSLCFSPNRYWLCAATEN----SIRIWDLESKSVVEDL-------KVDLKAEAEKTDGSTGI---------------------GNKTKVIYCTSLNWSADGNTLFSGYT-----DGVIRVWGIG.............................................................................................................................. 324
66 -27.100[S] COG4946 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system  ali follow..  8  13................................................................................................AITSFRCES--TIYRYIGVKEFCGKHYILKIIHYHMKAYYMYPDIRGDLISFTSDDDVWLLSLKDMKPLRITSGLGVSTRPKISPSGRKVAFSVIW--------LKSGKQGGDIYVVEDGQARRVTYFGSRNSRVAGWISEDEIIVITDFHTTEAYKVNVNNGKTEKLPFGMLSNIVIKDDIIVIARGYQDLPKGYKGGTKGELWISSDGGKTF----------------EKFVSLDGNVSWPMIVRERVYFLSDHEGVGNLYSVDLKGKDLRRHTNFTDYYCRNASSDGKRIVFQIYLYDPEKDSLTKLDINLPTDRKKKQPKFVNVMEYMNEAVVNGNYIALVSRGK-------------VFLMRPWDGPSVQLGKKQGVKYRQIQVLPNGDVIGVNDEDK----LVILGKDGS------EKVINKDFSRIERVKVSPDGKKVLLS---NNKLELWVYEIDNARLIDKSEYDLILEFDWHPNAEWFAYAFPEGYYTQS-IKLAHIDGKVVITTPYGYDFSPSFDPDGRYLYFLAARHLDPTNDKVIFNLSFQRVVKPYLVVLGNYYSPFNQPLDEANSNDKNVIIEGIEDRVVPFPIEEENYVQ............................ 594
67 -27.000[U] KOG0276 Vesicle coat complex COPI, beta` subunit  ali follow..  7  26..................................................................................................................................................................................................TEPWILASLYSGTLCIWNYQTQVMAKSFEVTELPVRSAKFVARKQWVVAGADDMYIRVYNYNTMDKVKVFEAHSIRCVAVHPTLPYVLS----------SSDDMLIKLWDWEKGWACTQ--------------IFEGHSHYVMQVTFNPKDTFASASLDRTIKIWNLGSPDPNFTLDAHQKGVNCVDYFTGGDKPYLIT-----GSDDHTAKVWDYQTKSCVQTLEGHTHNVSAVCFHPELPIIITGSEDGT------------VRIWHATTYRLENTLNYGLERVWAIGYIKSSRRVVIGYDEGDNTGKIIWAKHNEIQTANIKSELGTCDLYPQSLKHNPNGRFVVVCGDGEY---IIYTALAWRNR----SFGSGLEFVWSSEGECAVRESSSK-CSSDFICFYDWAECRLIQRIDVTVKNLYWADSGDLVAIASDTSFY............................................................................................. 487
68 -26.800[R] KOG2919 Guanine nucleotide-binding protein  ali follow..  8  69..........................................................................................................................................................................................................EEESVRVVDIEDTLELTSNGNEAKPEDQELAIAPVLQYFQGALVELGRRCWTSSTEA------QHYTKGCYWSPDGTCLLV----------PVHLDGMHVIEMPSDLYSADTVQPARSLTKLQSEVHVPEGGTVYDCVWYPHMNWLATRQHEPIHMWDAFDGSLRCSYS-EVMAAISLAFSHDGEQIY--------AGYKRCIKIFDTSRPGRFCDDYPVKFAISCIAQTTAHPHTLTCGNWHGY--------IQHFDLRCSHKQGPLFTLGGHKGGITQLRYGEFGNGWHLFSGARKCDKILQWDMRNY---KQPLVELQRHVDTNQRIQFDSDSNWLAS---GDTRGFVNVWDLKKYGDPSVLPLHSCNGVALNPAMPILATSSG-----QFHFTDQSAQGDNVTLNGTETTELPAPADVNQNQKEVLYENAVV............................................................................................ 479
69 -26.800[YU] KOG2445 Nuclear pore complex component (sc Seh1)  ali follow..  10  2..........................................................................................................................................................................................................................QPFDSGHDDLVHDVVYDFYGRHVATCSSDQIKVFKLDKDTSNWELSDDSSIVAIDWASPE--------YGRIIASASYDKTVKLWEEDPDQEECS-----------------------------------------------GRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC-----LGNDGILRLYDALEPSDLRSWTLHLQSDFCLSWCPSRFSPEKLAVSALEQA-------IIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGR--LIATGCKDGRIRIFKITEK----LSPLASEESLTNSNMFDNSADVDMDAQGRSSNTEEKAELQSNLQVELLSEHDDHNVWSVSWNLTGTILSSAGD-----DGKVRLWKAT.............................................................................................................................. 334
70 -26.200[S] KOG1409 Uncharacterized conserved protein, contains WD40 repeats and FYVE domains  ali follow..  7  2.............................................................................................................................................................................................................................................AAIINQRVEQGESSMGGAKPALLHRITGHVAINDVILLSKDEGVWT----------ASDDRSVRLYLKRDNDQFWPSIHHFMPV-------------APTSLYYSEETYKLLVLINGNVYEFDFNSMTESRKWTCHAGPISGLGFALSSELIF-------SCSRDKSIVWHCSENSNKMGS---YLLENSCTAMVIDLPFVFVGDHG----------GHVTVLRIVDNQPNLVSKLSAHTNAITSLTWDGNKKVLYSGSSD---HLIIMWDIGGG---RGEAYELNGHNGKVTTLCAAPAAKRLFSAD---EHGKLMCWDMNCKRVETPEWKTSKCNQPFFWNLQAMWQRKVPPMGYETKIRICNDCNARMKDNIHTGITAMHLQETLGLLVTSGQNRVIM............................................................................................ 400
71 -26.100[R] KOG0322 G-protein beta subunit-like protein GNB1L, contains WD repeats  ali follow..  12  1................................................................................................................................................................................................................................................MAVLPPDPVFSLRSPDM---------GAVNSLCFQESDRLLA-----------GTIKGSVFLWDLQTNRSALHFEVGSD---------------PITSLHHTPDR-LVTQEKGGTITMFSIGGSSYVKERSIPGNALHTNTSKTNEQLLFY-------PCEESSIGVLHVTDAAAPTQILVPDDPQFKPFECASQLFLLAGYESGHFLTWDISSS-------------VILDVMELAQDATSVDYDPVTNRGIVGGPTD---KLISFSYQRSSMQMQLGSELCIKNPGVNGVRIRPDQKVFASAG----DGRIRIFSWKSLRPLAVLTNGGVMDLAFSSQAPIMAAAGM-----DGQISLWDLYN............................................................................................................................. 323
72 -26.000[S] KOG3881 Uncharacterized conserved protein  ali follow..  8  5...................................................................................................................................................................................................................................IPPENLGCPPFRALTFDSLGLIKVTEARGQERGIPTVVNTLAASIDDRLRNPLLAV----------ARKDGNVEVINPCNGDLHFSYSVFGDDGCSPEDNEISALH--------ERSCTLLTCTKKGDVSLRSVKFPDAHGNSTDDASEILVGKVDGSENFSLF-------GGKRVEANIWDLEQCTKIWSAKCPPKNNLGITWFTS-----------------------------------------------TFLSKDDHRKFVTGTKS---HQVRLYDISTQ---RRPVLSFDFRETAITSIAEDPDGHTIYVG---NASADLASFDIRTGKLLGSFLSGSIRSVVRHPQHQVIASC-----GLDRYLRVYDVKTRQLISAVFQHLTGLVFDSGFSGEETAVANTVAEAATEEKMTIMDQEDDETEKAPVKRKKSKKEKRSREIVFEGEDDEENEDEIEKAPVKTKKSKKEKRSREKVSEGEEKDELRSKKTREHKKKT. 459
73 -25.900[R] KOG1963 WD40 repeat protein  ali follow..  9  27...........................................VSKIPAVYSNDNKFVFLTYDIGIFSLIT-----DCINRIFFPNNLANLLPVAVLLSPENAFQSGYVCVDWSNSELLREISTRVHAASFSGKLLFAVTDTPASDSASS-QDRFTLYALSPSTSKEGSSILIPTFVSKFNEFLALDSSLRDNNLATVAVITTDKAIFSLNVPKKKRSQRWIHRFNMPQKLTNVSLCGSACAVSDDEGIHVINDISNEKFNPQILHNPLNGLSWALNGEYLLS----------GGQEGVLVLWQMETSHR----------------QFLPRLGSSILSIATSHDSDSYAHLGDNSLVVIRAVDLAEQIHVSGINSFESKYLTSTGPKNTSLLMSSSSFNGHSVSVQEYDLTKDSTIRKFEA-HVGSVAVTSSRNGLYIATI-CTNIIDEQQRNVKQTALKFWQFDSVQKTWVLMTRLEVVTALKMMTSSNRFITVGTD---ATLRIWALLPGSSA-HSQASIKQRYGFSKALTCSLDDSIIGFG----YGSCMHFINSETLEEISTVDLPHGGQLE--LNAEHCVIIS------QRRLLVWNVISAAVIDFNSSYSRLIIFSPDSPKIQSIHIFKTLPVALHYLHGGFVVLDNKSAGDLTTKIPSAQLSIDNTSRSLLGDFQKRNVPLLNLENPISGSQGLHYKRLTTDMIHNLFNVSPVNMQAIYNTFS 779
74 -25.800[S] KOG0270 WD40 repeat-containing protein  ali follow..  7  23..DDEEVERINQLAQLNLDDAKATLEEAEGESGVEDDAATGSSNKLKDQLDIDDDLKEYNLEEYD--DEEIADNEGGKDVSMFPGLSNDSDVKFHEGEKGEDP------YISLPNQEDSQEEKQEL---QVYPSDNLVLAARTEDDVSYLDIYVYDDGAGFHSSDIPVEEGDEAD---------------------DVARGLVRDPALYVHHDLMLPAFPLCVEWLDYKVGSNSEEAANYAAIGTFDPQIEIWKKSKTGHITTHHTDAVLSMAHNKYFRSVLA---------STSADHTVKLWDLNSGNAARSLASIHSNK-------------NVSSSEWHMLNGLLTGGYDSRVALTDVRISDESQMSKYAGEEIETVTFASENIILC--------GTDSGNVYSFDIENRKPVWTLKAHDAGISTLCSNKFIPGMMSTGAMGEKT---KLWKFPLDDATNTKGPSMVLSRDFDVGNVLTSSFAPDIEVAGTMVIGGVNKVLKLWDVFT---NRSVRKSFKSELENVQARAKEEAQKIGKSSRIAR---KYTSNDNPDTVITIDDEDEEEREGGDEHDDM.................................................................................................................................................... 575
75 -25.300[A] KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)  ali follow..  10  168................................................................................................................................................................................................................................GLGENAINKRQYEDEERKQQQREQDQATWYHEGPDSLRIARPRAKDRLVRAREALEVPS--------AARAGRMVEMQKKLQSLAPLCSQVGDTR---------------PVSSAAFSEDSSLLLTSSSGLCKLWSVPDCELKQTLRGHASYVGGVALRPGVKADEENVVAMASGGHDGAVKLWGFNNEESIADITGHMPHRVKVAFHPSGRFLATACYDSS------------WRLWDLEQKTEVLHQEGHAKPVHCLSYHSDGSVLVTGGLD---AFGRVWDLRTG----RCIMFLEGHLGAVFGVDFSPNGFHIATGSQ---DNTCKIWDLRRRQPVYTIPAHTISDVKYQQEGSFLVTCSY-----DSTTKIWSNKT-KTLQGHDNKVISVDIAPNSQYIATTSFDRTFK............................................................................................ 547
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;