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Query: [L] KOG2327 DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen), from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELLEALTKHFQDLast
1 -167.000[L] KOG2327 DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen)  ali  100  1MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELLEALTKHFQD 609
2 -116.000[L] KOG2326 DNA-binding subunit of a DNA-dependent protein kinase (Ku80 autoantigen)  ali follow..  13  2................................SDKECTVFVLDLGKDMGTCHHGRSHSDLEWTLSYFHDELSHKFLANRKDVVGIVGYKCDDTKNDLAYWNISVLYPIQTALFSKLQSVSQTLKPSN---------TMQGDLISAIVVSFDLMARHCKKNKWKKKMIVLTAARGIIDFSDYIGIAEQLLQHDVFLGVYGVDFDQEDSEPLKESQKKENEVRIQEFVESCHGQYCTFQQIYNNIGKPWVRKVRPVAIFRGTFSIGNSISIQVERYPRTRLTKPPTSSAFYENDMSKNYECLNIEKTNDSFEVKREDLESGYSYGRTIVPISRSDEDVLALDTIPGYEILGFIPKSSLPIYYTISDTNIIVPKDD--FESKLNFSAFVQSLEREHRYALARFVSKDKGVPVLLVLMPYVEF--------KRHYLVDIQLPFAEDVRPYSFSSNEEDMRQIDFAVSNYIDNMDLDFEPENTFSMIPHRLQQAISYYANSPEGDLPQPNIYLTRYTNPPKSLLDNCILDLKLIKEKLTVNVPVKPKYSSQETAFDTGAPISEEQIEEGEKLLVLHVSEKDPVGTFTEVLKN-PFGLEDALTEMEKVIKNLIDK 621
3 -41.200[S] COG1273 Uncharacterized conserved protein  ali follow..  14  19..................................................................................................................................................................................................................................................LCQEFCVMVAPRANWKGFIKYG--VACPVALYTAASSSERIAFNTLNRKTGNRVKREF--VDSETGDPVERDEQVKGYEVEGQYIILEPEEVAAAVPDSDKTLKIDAFIPCHEIDDVY-FDKPYYLAPDK----MGTDAFLLLRDGMKKAKVAAIARTVLFRRV--RTVLIRPH-------------KGLIATTLNFDYEVRSSQELPDLKIEGEMLELAEHIIGTKKGSFDASAFDDRYEAAVAELVKAKIEGRALPKKKAPP--------ASKPSDLLQALRESAGVVAKAASKRTAANVNKGTSRQKVAKAAAAKTKSAASQTRRA...................................... 322
4 -18.000[O] COG5148 26S proteasome regulatory complex, subunit RPN10/PSMD4  ali follow..  14  4...................................EATVLVIDNSEYSRN--GDFPRTRFEAQIDSVEFIFQAKRNSNPENTVGLISGAGANPR---------VLSTFTAEFGKILAGLHDT-------------QIEGKLHMATALQIAQLTLKHRQNKVQHQRIVAFVCSPISDSRDELIRLAKTLKKNNVAVDIINF......................................................................................................................................................................................................................................................................................................................................................................................................................... 144
5 -15.000[KL] KOG2487 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4  ali follow..  10  1MDE------------FQTLKQNASWDISEDANDTPSLLVVILDANPASWYS--LSKKVPVSKVLADITVFLNAHLAFHHDNRVAVLASHSDKVEIAPEQKVAEVDPTKEANTYRKFREVDDLVLSGMKRLMSSTDKVSRKTMISGALSRALAYINQVQNTLRSRILIFSLTGDVALQYIPTMNCIFCAQKKNIPINVCNIE........................................................................................................................................................................................................................................................................................................................................................................................................................ 194
6 -14.500[KL] COG5151 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  12  38..TWEGEYQRSWDIVQEDAEGSLVGVIAGLIQSGKRHMVLVLDLSNSMEE--RDFHHKRFDLQIKYASEFVLEFFEQNPISQLSIIGVMDGIAH---------RITDLHGNPQSHIQKLKSLRDCS------------GNFSLQNALEMARASLSHIASH-GTREVLIIFGSILSSDPGDIFKTIDALVHDSIRVRIVGL......................................................................................................................................................................................................................................................................................................................................................................................................................... 227
7 -14.500[KL] KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1  ali follow..  12  38..TWEGEYQRSWDIVQEDAEGSLVGVIAGLIQSGKRHMVLVLDLSNSMEE--RDFHHKRFDLQIKYASEFVLEFFEQNPISQLSIIGVMDGIAH---------RITDLHGNPQSHIQKLKSLRDCS------------GNFSLQNALEMARASLSHIASH-GTREVLIIFGSILSSDPGDIFKTIDALVHDSIRVRIVGL......................................................................................................................................................................................................................................................................................................................................................................................................................... 227
8 -13.900[O] KOG2884 26S proteasome regulatory complex, subunit RPN10/PSMD4  ali follow..  16  4...................................ESTMVCVDNSEYMRN--GDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLA----------NDCEVLTTLTPDTGRILSKLHTV-------------QPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINF......................................................................................................................................................................................................................................................................................................................................................................................................................... 143
9 -12.500[KL] COG5242 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4  ali follow..  7  1MDA-------------SDPTFKHARSRKQVTEESPSLLTVIIEIAPKLWTTEEGNEKGSIIKVLEALIVFLNAHLAFNSANKVAVIAAYSQGIKSDLKIINSDMYRRFRNVDETLVEEIYKLFELEKKQIEQNSQRSTLAGAMSAGLTYVNRISKESVTTSLKSRLLVLTCGSGSSKDEIFQYIPIMNCIFSATKMKCPIDVVKIGGSKE............................................................................................................................................................................................................................................................................................................................................................................................................... 220
10 -12.100[D] KOG4259 Putative nucleic acid-binding protein Hcc-1/proliferation associated cytokine-inducible protein, contains SAP domain  ali follow..  23  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MPESDVTKMKVADLKRELKLRGLAVNGNKTELQDRLQTALLE 42
11 -12.000[R] KOG3768 DEAD box RNA helicase  ali follow..  10  4.....................................LLFLIDTSASM-NQRSHLGTTYLDTAKGAVETFMKLR--ASRGDRYMLVTFEEPPY---------AIKAGWKENHATFMNELKNLQAEG-------------LTTLGQSLRTAFDLLNLNRLVTGIDNIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTLFALVLRLPGTMSVESEQLTGVPLDDS--------AITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVI--NFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPES--DQNSPTLPPRTSHPVVKFSCTD----------CEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHP--------KASTALNCVNLFVMPY---LDDLFKVHKAKPTLKWRQSFESYLKTM-----PPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVLNMKEYTGFQVALLNKDLKPQTFRNA-PRRNLLDHLTRMRSN 562
12 -10.800[R] COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain  ali follow..  15  6.....................................IFFVLDCSESM----IGENLKKMNDGLQMIINDLKKDPHALETAWISVIAFAGV----------AKTIVPLVEVVSFYPPRLP----------------IGGGTSLGAALQELTRQIDTQVRKTTEERVYLLTDGRPTDDTTAEITRWKTHYARKVNLIAIGL......................................................................................................................................................................................................................................................................................................................................................................................................................... 145
13 -9.850[R] COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain  ali follow..  13  41.....................................LSLVIDRSGSM-------AGAALHHALKAAESVVDQL---EPKDILSVVVYDDA---------------------VDTVVPPQPVTDKPALKKSIRQVRAGGITNLSGGWLKGCEYVKHQLDPQKINRVLLLTDGHANMGIQDPKI--LTATSTQKAEEGITTTTLGFAQG--------FNEDLLIGMARAANGNFYFIQSIDEAAEVFSIELDSLRSVVGQNLKVTLELADGITLVDTLSLAK........................................................................................................................................................................................................................................................................................................................................ 243
14 -9.350[H] COG1240 Mg-chelatase subunit ChlD  ali follow..  15  138....................EQGDIRSKRLVRKAGALVVFVVDASGSM-------ALNRMQSAKGAVMQLLTEAY--QNRDQVALIPFRGEQAE---------VLLPPTRSIALARNRLERL-------------PCGGGSPLAHGLTQAVRVGVNAQMGGDIGQIVAITDGRGNIPLSRDIKAELLDIAARIRALGMQLLVIDTESK................................................................................................................................................................................................................................................................................................................................................................................................................. 308
15 -9.320[U] KOG1985 Vesicle coat complex COPII, subunit SEC24/subunit SFB2  ali follow..  8  331....................................VYVFLIDISFVSIS------SGMVGTASRAILESLDRIPNKEGRAKVAFIGVDSASVSPGAEEATQLVVSDLEEPFLPRNQDLQGIENLLERFQSMFATTRDSSNALGPGLKAAHRLIENIGG-----KICCLISSNRESSLLHPNDSFYKSFAVECSTSQVSVDMFLFSSQYQDVATLSCLPRYTSGKTQFYHRWNASRSEDALKFASELTNYLSMEIELEAVMRVRGSNGLRMSSFYGNFFNRSSDLCAFPSFPRDQSYVVEVVIEDTITKPFVSFQTAMLHT-GERRIRVLT-------------ISLPTTNSMTDLYASADQVAIAQYLTVRASEKALSSTLNEARDSIISKLVEILEVYKKNLAGQSTNLRLLP----------------LLCLAL-----TKHTGFRRSSHISSDLRSIALCYLSTLPTPLLMRYIY-PTLYSLHDMPIEAGTVTEQGVVLPSALNLTSALLQSFGLYLVDTHIHQFGKDAVPQLLIDAFGVNSLADLKAGRFTMPVIDNPLNVRINAGDGDPQLRSWFFSHFVEDRSENSPSYLQFLQTLKEKVRD 926
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.