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Query: [E] KOG2367 Alpha-isopropylmalate synthase/homocitrate synthase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVKHSFIALAEHASKLRRSIPPVKLTYKNMLRDPSVKYRAFAPPKMVKRIWPDKTIQKAPRWLSTDLRDGNQSLPDPMSVAQKKEYFHKLINIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVGIQCLVQSREHLIKRTVEALTGAKRATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPATVEVASPNVYADQIEYFSTHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSISEIVHRCNKIPIPPRAPYGGELVVSAFSGSHQDAIKKGFAIQNKKQAQGETRWRIPYLPLDPKDIGRDYEAVIRVNSQSGKGGAAWVIMRSLGLDVPRPMQVDFSNTLQKNADALGRELKSEEITKLFKETYNYNNNEHIYVTLLNYEVKKLNPERRALVGQVEINDKVVNIEGYGNGPISSLVDALSNLLNVKLSVQNYSEHSLGSGSATQAASFINLSYIKDINNHATSNMWGVGVSEDTGDASIKAVFATVNNIIHSGDVLLAELast
1 -145.000[E] KOG2367 Alpha-isopropylmalate synthase/homocitrate synthase  ali  100  1MVKHSFIALAEHASKLRRSIPPVKLTYKNMLRDPSVKYRAFAPPKMVKRIWPDKTIQKAPRWLSTDLRDGNQSLPDPMSVAQKKEYFHKLINIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVGIQCLVQSREHLIKRTVEALTGAKRATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPATVEVASPNVYADQIEYFSTHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSISEIVHRCNKIPIPPRAPYGGELVVSAFSGSHQDAIKKGFAIQNKKQAQGETRWRIPYLPLDPKDIGRDYEAVIRVNSQSGKGGAAWVIMRSLGLDVPRPMQVDFSNTLQKNADALGRELKSEEITKLFKETYNYNNNEHIYVTLLNYEVKKLNPERRALVGQVEINDKVVNIEGYGNGPISSLVDALSNLLNVKLSVQNYSEHSLGSGSATQAASFINLSYIKDINNHATSNMWGVGVSEDTGDASIKAVFATVNNIIHSGDVLLAE 604
2 -102.000[E] COG0119 Isopropylmalate/homocitrate/citramalate synthases  ali follow..  20  1..................................................................MRDGEQTPGVALTREKKLLIARALDEMRINVIEAGSAITSAGERESIKAVANAGLD-AEICSYCRIVKMDV----DHALECDVDSIHLVAPVSDLHIKTKIKKDRDTVRQIAAEVTEYAKDHGLI----------VELSGEDASRADPEFLKAIYSDGIDAG------ADRLCFCDTVGLLVPEKTTEIFRDLSSSL----KAPISIHCHNDFGLATANTVAALAAGAKQSHVTINGLGERAGNASLEEVVMSLEWYKYDTGIKHEQIYRTSRLVSRLTGIPVSPNKALVGGNAFTHEAGIHVHGLLAD---------------KSTYEPMSPEYIGRQRQIVLGKHA---GRSSITLALKEMGLEADEAQTEEIFNRVKQMGD-QGKHITDADLQTIAETVL--DIYKEPIVKLEEFTIVSGNRVTPTASIKLNVKDKEIVQAGIGNGPVDAVINAIRRAVSSDVVLEEYHVDSITGGTDALVEVRVKLS-------KNGKVITASGARTDIIMASVEAVMNGMNRLIREE...... 483
3 -54.500[C] COG5016 Pyruvate/oxaloacetate carboxyltransferase  ali follow..  13  2.....................................................TTQNKKIAITDVVLRDAHQSLATRMRLDDMLPIAHELDQIGYWSLEAWGGATFDACIRFLGEDPWVRLRELKQAMPNTPLQMLLRQNLLGYRHYADDVVDRFVERSVKNGMSVFRVDAMNDPRNMKQALQAVKRNGGHA--------QGTLSYTTSPVHNLETWLEITEQLLEIG------VDSVVIKDMSGILTPVEAYKLVSEIKKRY----DVQLHLHCHATTGMAEMALLKAVEAGIDGIDTSISSMSGTYGHPSTEALVATLQGTQYDTGLDIHKLEHIAAYFREVRKKYAKFEGQLRGSDSRILVAQVPGGMLTNLESQLKQQNASDKLDEVLKEIPRVREDLG--FIPLVTPTSQIVGTQAVINVLMGERYKTIAK---ETAGILKGEYGRTPAPVNAELQAKVLDGGQPITDRPADHIA----------PEMEKLATEIKQQAKEKGIKLAENEIDDVLIVALFPQIGWKFRGNPDAFEPAPTLETAKPAEKPAAPVAKTPVS........................................ 485
4 -12.000[C] COG1038 Pyruvate carboxylase  ali follow..  13  557........................................................EKRVLVTDTTMRDGHQSLATRVRTHDIARVASVYSKAGGATFDVSMRFLTEDPWERLSLIREGAPRGANGVGYKNYPDNVVKYFVRQAARGGVDLFRVFDCLNWV-----------ENMRVSMDAIAEENKLCEATICYTG-----DLLNSARPKYDLKYYTNLAVELEKAG------AHIIAVKDMAGLLKPAAAKVLFKALREAT----GLPIHFHTHDTSGISAATVLAAVDAGVDAVDAAMDAFSGNTSQPCLGSIVEALSGSERDTGLDTEWIRRISFYWEAVRNQYAAFESDLKGPAS.................................................................................................................................................................................................................................................... 853
5 -6.890[S] COG4297 Uncharacterized protein containing double-stranded beta helix domain  ali follow..  15  3.........................................................................................................................................................................................................................AHLIPLAENAGVPNNPQLPARRYPSALKGQSAAQVRDHLKARDWFGSWTGQIYNFHHYHSH-----AHEVIVVLRGQAGVI----GVGHCSLHHSADFQIMGAYAAGRSWDICRPEDTDLAWARARIAEVPDWVQEPV......................................................................................................................................................................................................................................................... 152
6 -6.230[G] COG3623 Putative L-xylulose-5-phosphate 3-epimerase  ali follow..  12  15............................................................................QFTWRERLQFAK---DLGFDFVEMSVLEWTKEERLDLVKAIYE--TGIRIPTICAKSLKLMKQCIELAQDLGVRTIQLA--GYDVYYEKKSPETRARFIKNLRQSCDWAEEAQ------------VMLSIEIMDDPFINSIEKYLAVEKEIDSPY--------YPDAGNVSA-NDLWSEFYNGHKSI---------AALH------LKDTYAVTETSKGQFRDVPFG----QGCVDWQELFAVLKKTNYNGPFLIEMWSENCDTVEETKAAIKEAQDFL---YPLIEKAGL............................................................................................................................................................................................................................................. 286
7 -6.090[G] COG0269 3-hexulose-6-phosphate synthase and related proteins  ali follow..  9  1.....................................................MSLPMLQVALDNQ------------TMDSAYETTRLIAE--VDIIEVGTILCVGEGVRAVRDLKALYPHKIVLADAKIA--DAGKILSRMCFEANADWVTVICCADINTAKGALDVAKEFNGDVQIELTGYWTWEQAQQWRDAGIGQVVYHRSRDAQAAGVAWGEADITAIKDLPLFKGIPIHVFIAGRSIDAASPVEAARQFKRSIAEL..................................................................................................................................................................................................................................................................................................................................................... 214
8 -6.080[G] COG3622 Hydroxypyruvate isomerase  ali follow..  14  12.............................................................................FTEVDFLERFDAAAKAGFAGVEYLFP--YDVEAEAIKARLEAN--GLEQVLFNLPAGDWAKGERGIACHPDR---------------------VQEFREGVDKAIAYARVLGNRQVNCLAGIRPQGHDCASVEKTFVDNLRYAADKLEAAG-------IRLVMEMINTLDIPGFYLQNTRQALEIRDKVGSANLFLHMQIMEG-DLARTLENQLAAINHVQ--LADNPGRTGEINYRFLFEHLDRIGYQGWIGCE................................................................................................................................................................................................................................................................................ 240
9 -6.050[R] COG0535 Predicted Fe-S oxidoreductases  ali follow..  9  12.............................................................DFNLTNGASGPKLDNELKTEEILQTIDALHIIGALKIAGGEPFIRRDIFNILSHACSLPGWGISVITNGFYLNSLTVEKLKAQCPNLSINISVDGSTPAGYQLNRPDADPQPLFERVLSGIDNVVRSGMSNSVNFT-----------ITKATLHDIEATYELVVD-----RIGADNMVAIKFF-EIPYDMWDEHFVALTRAKLGGKLERLQISVPAAWEFYARMREVGDVAGISEL--CISSDGESCGNL---------------REHSLQRIWQESSCLMALRELKLFDLNGNCTKCGVREGGGSRSRAFSREGDFRDM............................................................................................................................................................................................................................... 369
10 -5.690[G] KOG4518 Hydroxypyruvate isomerase  ali follow..  10  24..............................................................IRLAHQNGFRAVEIPYPEGETSDVVSAVKETGVVVSLVNLAFDKSDDQLRFGSTSVPGSEKL---------RSQLDATIDFARQVNCGKIHLTAGLFK-------GGQESDYTKTYTANLKIAADSLRA--------------------SKMIGVIEPINKYAVPGYYMNSYSKAAGILADVAADNIQLLADL-----------------YHLQHLHG-NVSKTLEEYKALIGHFQ--IAQVPHRSGELDYGFVFKALQEFGYDGWIGCE................................................................................................................................................................................................................................................................................ 243
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 5 1 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205