Scheduled maintenance will begin on May 30th, 2025. Server will be temporarily unavailable — learn more.
current user: public
If you have questions about the server, please let us know.

Query: [A] KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580    .  590    .  600    .  610    .  620    .  630    .  640    .  650
# Score Template Links and tools%idFirst MVATMDLNASPQPEEDDEPYVRHLEDYSSRDERIESAVEIARREREERKKRMRYDKPTHNSQPVFRDQYYQNRNTKAYDRYKIPQGWLDCPPSGNEIGFLVPSKVPLNESYNNHVPPGSRYSFKQVIHNQRIAGRKLGLVIDLTNTTRYYSTTDLKKEGIKHVKIACKGRDAVPDNVSVNAFVNEVNQFVLNLKHSKKYILVHCTHGHNRTGFMIVHYLMRSGPMNVTQALKIFSDARPPGIYKPDYIDALYSFYHEIKPESVICPSTPEWKRSTELDLNGEALPDDEDDDGGPAGPVQGFQEESHQVDVKMSNDDVLGDEIPPDQEEGYRQFFYRMLSLNIGVGNFKSENLQLLRQRYYYATWKADGTRYMMLLTTDGCYIVDRSFRFRRVQMRFPFRHPTEGISDKVHHFTLLDGEMIIDTLPDKQKQERRYLIYDMVAINGQSVVERPFYERWKMLEKEVIDPRNHEKARSHIYRYDLEPFRVRRKDFWLLSAVEKVLKGFIPSLSHEADGLIFQGWDDPYVPRTHEGLLKWKYPEMNSVDFLYEQDESGRGMLSLFERGKKKHMDGNSVVFRELQATNAETATDDSDPAEYSGKIVECSWDQDEKVWVSMRVRVDKSTPNDINTFRKVSTIIPLYILELLHYWLTIILYLast
1 -196.000[A] KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit  ali  100  1MVATMDLNASPQPEEDDEPYVRHLEDYSSRDERIESAVEIARREREERKKRMRYDKPTHNSQPVFRDQYYQNRNTKAYDRYKIPQGWLDCPPSGNEIGFLVPSKVPLNESYNNHVPPGSRYSFKQVIHNQRIAGRKLGLVIDLTNTTRYYSTTDLKKEGIKHVKIACKGRDAVPDNVSVNAFVNEVNQFVLNLKHSKKYILVHCTHGHNRTGFMIVHYLMRSGPMNVTQALKIFSDARPPGIYKPDYIDALYSFYHEIKPESVICPSTPEWKRSTELDLNGEALPDDEDDDGGPAGPVQGFQEESHQVDVKMSNDDVLGDEIPPDQEEGYRQFFYRMLSLNIGVGNFKSENLQLLRQRYYYATWKADGTRYMMLLTTDGCYIVDRSFRFRRVQMRFPFRHPTEGISDKVHHFTLLDGEMIIDTLPDKQKQERRYLIYDMVAINGQSVVERPFYERWKMLEKEVIDPRNHEKARSHIYRYDLEPFRVRRKDFWLLSAVEKVLKGFIPSLSHEADGLIFQGWDDPYVPRTHEGLLKWKYPEMNSVDFLYEQDESGRGMLSLFERGKKKHMDGNSVVFRELQATNAETATDDSDPAEYSGKIVECSWDQDEKVWVSMRVRVDKSTPNDINTFRKVSTIIPLYILELLHYWLTIILY 653
2 -70.800[A] COG5226 mRNA capping enzyme, guanylyltransferase (alpha) subunit  ali follow..  26  19............................................................................................................................................................................................................................................................................................................................PRDDVRVLKTRIAKLLGTSPDTFPGSQPVSFSKKHLQALKEKNYFVCEKSDGIRCLLYMTEHPVYLFDRKMNFYHVEKIFY-PVENDKSGKKYHVDTLLDGELVLDIY-PGGKKQLRYLVFDCLACDGIVYMSRLLDKRLGIFAKSIQKPLDEYTKTH-MRETAIFPFLTSLKKMELGHGILKLFNEVIPRLRHGNDGLIFTCTETPYVSGTDQSLLKWKPKEMNTIDFMLKLEFAQPEEGDIEFQLGVWEGRNMYSFFAFMYVDEKEWEKLKSFNVPLSERIVECYLD-DENRWRFLRFRDDKRDANHISTVKSVLQSIEDGVSDLLKEMPIIR.. 364
3 -38.700[T] COG2453 Predicted protein-tyrosine phosphatase  ali follow..  15  103LACYMVLVQNWPPHLALAPLAQAEPPGFRDAGYAVSDYYITIQDCVYGLWRARESSILN--RNIDVHDYETYERVENGDFN-----W--------ISPKFIAFASPIQAGWNHASTRPK--KLPQPFAIVLDYFVANKVKLIVRLNGPLYDKKTFENVGIRHKEMYFEDGT-VPELSLVKEFIDLTEEVEE-----DGVIAVHCKAGLGRTGCLIGAYLIYKHCFTANEVIAYMRIMRPGMVVGPQQ...................................................................................................................................................................................................................................................................................................................................................................................................................... 329
4 -38.400[V] KOG1720 Protein tyrosine phosphatase CDC14  ali follow..  14  98LCCYMILVQAWTPHQVLQPLAQVDPPPFRDAGYSNADFEITIQDVVYGVWRAKEKGLID--HSFNLESYEKYEHVEFGDFN-----V--------LTPDFIAFASP-QEDHPKGYLATKSSHLNQPFKSVLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGT-CPDLSIVKNFVGAAETII----KRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQ...................................................................................................................................................................................................................................................................................................................................................................................................................... 326
5 -21.700[V] KOG1716 Dual specificity phosphatase  ali follow..  13  31.......................................................................................................CMPVSSDTVAPQQVHVSAFPSEILPEF----------LYLGSYDNASRSELLKTQGISR--VLNTVPMCQNLYRNSFTYHGLAIKFLDQCEKDKARVLVHCMSGKSRSPAVVVAYLMKRKGWRLAESHQWVKQRRPSTDISPGLDFGLETYLLFLKLLLIAFSLYTEFYQQLQEFEQGIFGSEMMSAMNIND...................................................................................................................................................................................................................................................................................................................................................................... 222
6 -18.900[L] KOG0966 ATP-dependent DNA ligase IV  ali follow..  10  43........................................................................GKSRSFKYYEIISNFVE-KTVGNNIYPALVLALPLIRTICSYLKLPKNSATEQRLKDWKQRVGKGGNLSSLLVEEIAKRRAEPSSKAITIDNV----------NHYLDSLSGDRFASGRGFKSLVKSKPFL----VENMSFVELKYFFDVIGGQEHKLLNCWHPDAQDYLSVISDLKVVTSKLYDPKVRLKDDDLSIKVGFAFAPQ---------------------------------------------------------------AKKVNLSYEKICRTLHDDFLVEEKMDGERIQVHYMNYGESI--IDYTYLYGASLSSGTISQHLRFTDSVKECVLDGEMVTFNSINNVDFHPLYMVFDLLYLNGTSLTPLPLHQRKQYLNSIL----------------SPLKNIVEIVRSSRCYGVESIKKSLEVAISLGSEGVVLKYYNSSYNVARNNNWIKVKPEYLENLDLIVHQGDSSEIVDHSSQEKHIQNSRRRVKKILSF-ISQEEFKEIDRKTRGHESIVLEIKSRSLDNT-YCKRIRYDKEWTDCYTL---------NDLYESRTVKSN.... 647
7 -18.800[V] KOG1717 Dual specificity phosphatase  ali follow..  15  218.........................................................................................................................CAKDSTNLDVLEEFGIKYILNVTPNPNLFE----NAGEFKYKQIPISDH----WSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST......................................................................................................................................................................................................................................................................................................................................................................... 381
8 -18.600[V] KOG1572 Predicted protein tyrosine phosphatase  ali follow..  14  57..........................................................................................LNFSMVDNGIFRSGFPDSANF-------------SFLQTL-----GLRSIIYLCPEPYPESNLQFKSNGIRLFQFGIEGNKEPFVNIPDHKIRMALKVLLDEKNHP---VLIHCKRGKHRTGCLVGCLRK-LQKWCLTSIFDEYQRFAAAKARVQRFMEIF.................................................................................................................................................................................................................................................................................................................................................................................................................. 198
9 -18.200[L] KOG0967 ATP-dependent DNA ligase I  ali follow..  9  198..............................................................................................DILCNMLR----VIATTPEDLVATVYLSANEIAPAHEGVELGIGAISEAFGRTEDHVKKQNTELGVAKGSRSTQTMMFKPEPLTVVKVFDTFRQIAKESGKDSN----------EKKKNRMKALLVATTDCEPLYLTRLLQAKLRLGFSGQTVLAALGQAAVYNEEHSKPPPNTKSPLEEAAKIVKQVFTVLPVYDIIVPALLSGGVWNLPKTCNFTLGVPIGPM----------------------AKPTKGVAEILNKFQDIVFTCEYKYDGERAQIHFMEDGTFEIYSRNAERNTGKYPDVALALSRLKKPSVKSFILDCEVVANVNVNDIKVGVCIFAFDMLYLNGQQLIQENLKIRREKLYESF----------------EEDPGYFQFATAVTSNDIDEIQKFLDASVDVGIGDSVDVPIAAFHGRGKRTG-GAFLLACYDEFQSICKIGTGFSDA-RVGDSLNPDVWFEPTEVGLCLLFRHSIVWVEMKGKKYVCLKVWEVK-DPDKG--RLLRVREDKK-PEEATSSEQIADLYQAQKHNH.......... 784
10 -17.700[L] COG1793 ATP-dependent DNA ligase  ali follow..  11  46............................................................................................LGDLRPPWEGVELGVAEKLCLRAVSKATGAAVSELEALYKKTGDVGEAARLAASKRPGLLAFGSQKPLEVSEVYLLKVARATGEGAQDMKVALLSSLFARATPEEGKYIARFVVGKLRLGVTIIEALSDAYGVNKEALEKAYHIYPDLGRLAKHVAEGKPLDEIRITPGVPVLPMLAQRLS--------------------------------------------------------------------------SASEILAKLGGSAICEYKYDGERAQIHLTPGGVKIFSRRLE-----THAYPDVVKAVKEAVSAKEAILEGEIVADVATAVELYPTVLYLFDVLYVDGEDLTEEPLIYRRVRLSEIVCET------------------KVSIAKWRIFDNAEAVDVFFHESVSMGTEGLICKSPSSIYEMGRGWNWIKYKRDYRDTVDFLLAAYDPSTDMFYTVCKVGSGFTDADLKKMYEILQPFKIPHRHPRVVSKMEQVVIEVIGAEITLS-FTGRYRSDKS-PEQATTVAEMLELYKRQKKV........... 580
11 -17.300[R] COG5350 Predicted protein tyrosine phosphatase  ali follow..  11  9..............................................................................................................................LSRIAEMAVKHKAMVTLIAKEQSFHRPAVVA-AERHLTLAMNDIAFKGTGDLIAPDDAHVLKLIDGEWDQSAPLLIHCWMGISRSAAAVIAALSLYPDQDETELAQRLRTVSPYVTPNSRIIAIGDR................................................................................................................................................................................................................................................................................................................................................................................................................ 139
12 -13.500[TR] KOG2283 Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases  ali follow..  10  2............................KDSENKGASSPDMEPSYGGGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQSVTSYTKGDLDFTYVTSRIIVMSFP-----LDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLS--PKSYRTAKFHSRVSEC------PIRQAPSLHNLFAVCRNMYNWLL--QNPKNVCVVHCLDGRAASSILVGAMFIFCNLYTPGPAIRLLYAKRPGIGLSPSHRRYLGYMCDLLADKPYRPHFKP................................................................................................................................................................................................................................................................................................................................................................................................ 230
13 -12.900[T] COG5599 Protein tyrosine phosphatase  ali follow..  11  412.........................EVLADLNTASIFYKFKRLEEMEMTRSLAFNDSKSDWCCLASSRSTSISR-KNRYTDIVPSDYINASHIDVGNKKYIACQAPKPG------------TLLDFWEMVWHNSGTNGVIVMLTNLSQYWDKPNGPPKYIHHFWVHTWFDKTHPDIESITGIIRCIDKV-----PNDGPMFVHCSAGVGRTGTFIADQILQVPKDFIFNCVNSLRSQRMKMVQNFEQFKFLYDVVDYLNSGVNQASK.................................................................................................................................................................................................................................................................................................................................................................................................. 707
14 -12.300[T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes  ali follow..  14  232.......KKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSR------ILQGRDSNIPGSDYINANYIKLLGPDENAKTYIASQGCLEATVNDQMAWQENSRVIVMTTREVEKGRN-PYSVTNCGEHDTYKLRTLLIREIWHYQYLSPDHGVPSEPGGVLSFLDQINQRQESLPHAGPII-VHCSAGIGRTGIIVIDMLMENIDIDIQKTIQMVRAQRSGMVQTEAQYKFIYV................................................................................................................................................................................................................................................................................................................................................................................................................ 510
15 -11.700[S] COG3453 Uncharacterized protein conserved in bacteria  ali follow..  9  4............................................................................................................RQINDEYSVSGQITVDDLDEIKAL----FKSIVCHRPDFE--IAARAQELGLEITHIPVGPMG--VTADAVKSMVDAL-------DEFQRPMLGYCRSG-ARSTAVYQQTLHIR............................................................................................................................................................................................................................................................................................................................................................................................................................................... 111
16 -11.500[T] KOG0789 Protein tyrosine phosphatase  ali follow..  14  450........................................................................DDKEKGHPDTRESFWR----VWDTRATYVVM---CCQIMENGVQKCGRYFPDETGATENYGFAEVQLLIELTSGTWKHSDDDPPIRTITHFQFL-KEGEGLEGEMSMDAFNYVNHR----TRNNLDPIIVHSSLGTGRACAFVGEYMFQMINGTARFFQVDFRTKRLGALQNGKQLFWVQN................................................................................................................................................................................................................................................................................................................................................................................................................ 640
17 -11.500[L] COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III  ali follow..  14  80................................................................................................................................................................................................................................................................................................................................................................RTFKRGEFYVEEKVDGYNVRVVKFRGKILGITRGGFICPFTTERISDF--PEEFFKDHPNLILVGEMALVEGPPYVKEDIQFFLFDIQELGTGRSL--PVEERLKIAEEYGIS-------------------HVEVFGKFTYKDLEEIYEIVERLSREGREGIVMKSPDMRKM-------VKYVTPYANINDIKIGARVFYE-----------------------------------LPPGYFTSRISRLAFYI---------AEKRLRGENFEELAKELGKALLQPLVESIHDVEQ.... 309
18 -10.400[T] COG2365 Protein tyrosine/serine phosphatase  ali follow..  13  85.....................................................................................NFRDMGGYKTKHGHHVKWGKLYRSSNLVNINQADAALLQKL---------HIKWICDLRSSSEVQAQPTPEIQGVLNKHIPIGTAKNEKTTQSVDGFKEIFSEILTDAKAGLPFV-FHCTAGKDRTG-VLAALLLTLLDVPEKTIFDDYAITN............................................................................................................................................................................................................................................................................................................................................................................................................................... 248
19 -9.320[G] KOG2178 Predicted sugar kinase  ali follow..  10  34LGCILSLLNKGRKESSMNSFNLDDVGVAEESLPPLAVFRGEMKRCCESLHIALENYLT-PDDERSGIVWRKLQKLKNVCYDAGFPRSDNYPCQTLFANWDPIYSSNTKEDIDSYESEIAFWRGGQVTQEGLKWLIENGTIVDLRAEDTFYQTDAISLGKITVVQIPID--RMAPKAEQVELFASIVSD------SSKRPIYVHSKEGVWRTSAMVSRYMTRPITKEIPVSEESKRREVSETKLGSNAVVSGKGVPDEQTDKVSEINEVDSRSASSQSKESGRFEGDTSASEFNGTVPTPQFSYTGVTNGNQIVDKDSIRRLAETGNSNGTLLPTSSQSLDFGNGKFSNGNVHASDNTNKSISDNRGNGFSAAPIAVPPSDNLSRAVGSHSVRESQTQRNNSGSSSDSSDDEAGAIEGNMCASATGVVRVQSRKKAEMFLVRTDGVSCTREKVTESSLAFTHLWKTTPKTVLLLKKLGQELMEEAKEAASFLYHQENMNVLVEPEVHDACLGGDGVILHASN--LFKGAVPPVV-----NLGSLGFLTSHPFEDFRQDLKRVIHGNNTLDGVYITLRRCEIYRKGKAMPGKVFDVLNEIVVDSKIECYEHDRLITKVQGD-ATPTG-STAYSTAAGVHPNVPCML--FTPICPH 783
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 4 6   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;