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Query: [C] KOG2451 Aldehyde dehydrogenase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSTSSKLSTNIKDLSLFDLEEFPARSYIGGKWVTAASGKTFDVENPGLNETLAPVTDMSVEETRKAIKVAHEAFLSYRNSDIKERYAILRRWYDLIMENADDLATMMTLENGKALGDAKGEVVYAAKFIDWFAGEALRISGDSSMSSNPQNRIITIKQPVGVVGIITPWNFPAAMITRKVGAALAAGCTVVIRPAAETPFTALALAKLAERAGVPAGVLNMVTANSPSEHGIELTTNPLIRKVSFTGSTNVGKILAKQSSSTLKKLSLELGGNAPFIVFEDADLEKAADALMACKFRGSGQTCVCANRIYVHSSVYDAFVDLVTERVSKFKLGYGLDAGVTHGPLISEKAISKVKQHVEDAVQKGGVVVTGGKVASNLGPMYFEPTVIINAKQGMLISEEETFGPVGALFKFDTEDEVVAWANDSPVGLAGYLFSKDISRVFRVGEALQVGMVGCNTGLVSDVLSPFGGVKESGFGREGSKYGISEYLDIKSLTISTLLast
1 -144.000[C] KOG2451 Aldehyde dehydrogenase  ali  100  1MSTSSKLSTNIKDLSLFDLEEFPARSYIGGKWVTAASGKTFDVENPGLNETLAPVTDMSVEETRKAIKVAHEAFLSYRNSDIKERYAILRRWYDLIMENADDLATMMTLENGKALGDAKGEVVYAAKFIDWFAGEALRISGDSSMSSNPQNRIITIKQPVGVVGIITPWNFPAAMITRKVGAALAAGCTVVIRPAAETPFTALALAKLAERAGVPAGVLNMVTANSPSEHGIELTTNPLIRKVSFTGSTNVGKILAKQSSSTLKKLSLELGGNAPFIVFEDADLEKAADALMACKFRGSGQTCVCANRIYVHSSVYDAFVDLVTERVSKFKLGYGLDAGVTHGPLISEKAISKVKQHVEDAVQKGGVVVTGGKVASNLGPMYFEPTVIINAKQGMLISEEETFGPVGALFKFDTEDEVVAWANDSPVGLAGYLFSKDISRVFRVGEALQVGMVGCNTGLVSDVLSPFGGVKESGFGREGSKYGISEYLDIKSLTISTL 498
2 -124.000[C] KOG2450 Aldehyde dehydrogenase  ali follow..  38  10............PVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYNDLAGCIKTLRYCAGWADKIQGRTIPID-GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGP-TAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGN-KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK.. 495
3 -123.000[EG] KOG2449 Methylmalonate semialdehyde dehydrogenase  ali follow..  26  18.SSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQH--EAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGE-AKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPPMFSFTGSRSSFRGDTNGKQGIQFYTQLKTITSQ.. 515
4 -121.000[C] COG1012 NAD-dependent aldehyde dehydrogenases  ali follow..  34  2..................SRMAEQQLYIHGGYTSATSGRTFETINPANGNVLATVQAAGREDVDRAVKSAQQGQKIWAAMTAMERSRILRRAVDILRERNDELAKLETLDTGKAYSETSTDIVTGADVLEYYAGLIPSLEGSQIPLR-ETSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYSEAGLPDGVFNVLPGVGA-ETGQYLTEHPGIAKVSFTGGVASGKKVMANSASSLKEVTMELGGKSPLIVFDDADLDLAADIAMMANFFSSGQVCTNGTRVFVPAKCNAAFEQKILARVERIRAGDVFDPQTNFGPLVSFPHRDNVLRYIAKGKEEGARVLCGGDVLKGDNGAWVAPTVFTDCSDEMTIVREEIFGPVMSILTYESEDEVIRRANDTDYGLAAGIVTADLNRAHRVIHQLEAGICWINTWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVE.. 482
5 -113.000[C] KOG2454 Betaine aldehyde dehydrogenase  ali follow..  25  2.....................................SSTLTCYCPGDGSLLGEVKLFNKSDIDQSIILAEEAQKEWKSTSFAERRNFLKALKENIIRNQDKYAEIACKDTGKTLVDAAGEILVTLEKINWTLANGEQSLRPTKRPNSSYKGGYVKYEPLGVIAALVSWNYPLHNALGPIISALFAGNAIVVKGSELTAWSTHQYCEMVRSMGHSPELVQCITCLP--DVADHLTSHSGIKHITFIGSQPIAKLVAASAAKQLTPLCLELGGKDPCILTDDHRLEEILSIVMRGVFQSAGQNCIGIERIIALDGVYDTIITKLYNRISTMRLGMYTQNDVDMGAMVSNNRFDHLESLIQDAVSKGARLVYGGHRFQHPKGNYFLPTLLVDATNEMKIAQEECFAPIALVFRAKSPEHALEIANGTEFGLGASVFGRDKQLCQYFTDNLETGMVAVNDFGAYLLQMPFGGCKKSGYGRFAGYEGLRGICNSKAIAYD.. 470
6 -112.000[F] KOG2452 Formyltetrahydrofolate dehydrogenase  ali follow..  37  420.....................MPHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKGAFENWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKHVGMSIQTFRYFAGWCDKIQGSTIPINQARNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGS-LVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCASNVKKVSLELGGESPFIIFADCDLNKAVQMGMSSVFFSKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR-PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFE.. 901
7 -100.000[C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogenase  ali follow..  26  122.................................AKVKGVSRPVLNPGDNDVVGTVTEIAEADVAKAMKAAQTATTSWSAVAPAERAACLERAADIMQRDMPALLGLVMREAGKSMPNAIAEVREAIDFLRYYAEQTRRTLG-------------VGHKALGPVVCISPWNFPLAIFTGQIAAALVAGNPVLAKPAEETPLIAAEGVRILHEGGIPADALQLLPGDG--RIGAALVAAPETCGVMFTGSTEVARLIQAQLASRLVPLIAETGGQNAMIVDSSALAEQVVFDVIASAFDSAGQRCSALRVLCLQEDVADRILTMLKGALRELSIGRTDQLKVDIGPVITDEAKNTIEKHIQAMRDLGRKVEQLPLGPETQNGTFVAPTIIE--IESLRDLKREVFGPVLHVVRYDDMESLIDDINSTGYGLTFGLHTRLDETIANVADRIRVGNIYINRNIIGAVVQPFGGRGLSGTGKAGGPLYLGRLVETAPIPPR.. 579
8 -97.500[E] KOG2455 Delta-1-pyrroline-5-carboxylate dehydrogenase  ali follow..  23  59.....................LEVPLVINGERIDNNERALFPQTNPANHQVLANVTQATEKDVMNAVKAAKDAKKDWYNLPFYDRSAIFLKAADLISTKRYDMLAATMLGQGKNVYQAEIDITELSDFFRYYVKYASDLYAQQPVESADGTWNAEYRPLEGFVYAVSPFNFTAIAANLIGAPALM-GNTVVWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPGDPV-QVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFLSDMFGILQSQNVVSGGNLRGFMGPVIHEQSFDKLVKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKAGNFYINDKCTGAVQQWFGGARMSGTDDKGGPNILSRFVSIRNTKEN.. 561
9 -69.300[E] COG0014 Gamma-glutamyl phosphate reductase  ali follow..  13  2..............................................................LEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSEIILNANAQDVADARANGLSELKGIADDVRQVCNLADPVGQVIDGGVLDGLRLERRRVPLGVIGVIYEARPNVTV--DVASLCLKTGNAVILRGGKETCRTNAATVVVIQDAGLPAGAVQAIDNPDRALVSEMLRMDKYIDMLIPRGGAGLHKLCREQS----TIPVITGGIGVCHIYVDESAEIAEALKVIVNAKTQRPSTCNTVETLLVNKNIAYSFLPALSKQMAESGVTLHADASA---------------------------------------LAQLQTGPAKVVAVKAEEYDDEFLSLDLNVKIVSDLDDAIAHIREHGTQHSDAILTRDMRNAQRFVNEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKGPMGLEALTTYKWIGIGD. 412
10 -62.800[C] KOG2456 Aldehyde dehydrogenase  ali follow..  24  1..............................................................MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVSQEVITVLGEIDFMLENLPTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVING--GVEETTELLKQR-FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLE-----GQKIAFGGET--DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKS. 429
11 -52.500[E] KOG4165 Gamma-glutamyl phosphate reductase  ali follow..  12  1................................................................DMAVAARESSRKLQALSSEDRKQILHDIANALEVNEKTIKAENDLDVAAALVMKPGKISSLAASVRQLAEMEDPI-GRVLKKTQVADDLILEKTSSPIGVLLIVFESRPDALVQVSSLAIRSGNGLLLKGGKEARRSNAILHKVITDA-IPETVGGKLIGLVTSREEIPDLLK-LDDVIDLVIPRGSNKLVSQIKNSTKIPVLGHADGICHVYVDKSGKLDMAKRIVSDAKL-DYPAACNAMETLLVHKDLEQNGFLDDLIYVLQTKGVTLYGG---------------------------------------------PRASAKLNIPETKSFHHEYSSKACTVEIVEDVYGAIDHIHQHGSAHTDCIVTEDSEVAEIFLRQVDSAAVFHNASTRFSDGFRFGLGAEVGISTSRGPVGVEGLLTTRWIMRGK. 400
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li Z, Ye Y, Godzik A. Flexible Structural Neighborhood--a database of protein structural similarities and alignments. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D277-80.