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Query: [K] KOG2494 C3H1-type Zn-finger protein, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTAVNVALIRDTKWLTLEVCREFQRGTCSRADADCKFAHPPRVCHVENGRVVACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKTAAAMFAQQMQLMLQNAQMSSLGSFPMTPSIPANPPMAFNPYIPHPGMGLVPAELVPNTPVLIPGNPPLAMPGAVGPKLMRSDKLEVCREFQRGNCTRGENDCRYAHPTDASMIEASDNTVTICMDYIKGRCSREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQLKFLast
1 -114.000[K] KOG2494 C3H1-type Zn-finger protein  ali  100  1MTAVNVALIRDTKWLTLEVCREFQRGTCSRADADCKFAHPPRVCHVENGRVVACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKTAAAMFAQQMQLMLQNAQMSSLGSFPMTPSIPANPPMAFNPYIPHPGMGLVPAELVPNTPVLIPGNPPLAMPGAVGPKLMRSDKLEVCREFQRGNCTRGENDCRYAHPTDASMIEASDNTVTICMDYIKGRCSREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQLKF 354
2 -36.900[R] COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins  ali follow..  24  231..............TRKTICPKFLNGRCNKAE-DCNLSH-----ELDPRRIPACRYFLLGKCNNPNCRYVHIHYS---------------------------------------------------------------------------------------------------ENAPICFEFAKGFCELGT-SCKNQH-------------ILQCTDYAMGSCNNPQCSLYHGAVSADVPEQTEAPISKTAGSINPEDSGSEIGSNSLESNLD................................................................................ 373
3 -31.700[R] KOG1595 CCCH-type Zn-finger protein  ali follow..  19  219.....................SFKVKPCSRA-TECPFVHPGENAR-----------------RRDPRKYPYTC--------------------------------------------------------------------------------------------------------VPCPEFRKGSCPKGDS-CEYAHGVFESWLHPAQYRTRLCKD--ETGCARRVCFFAHRRDELRPVNASTGSAMVSPRSSNQSPEMSVMSPLTLGSSPMNSPMANGVPLSPRNGGLWQNRVNSLTPPPLQLNGSRLKSTLSARDMDMEMELRFRGLDNRRLGDLKPSNLEETFGSYDS. 430
4 -29.300[S] KOG4791 Uncharacterized conserved protein  ali follow..  28  8...................CYFFFYSTCTKGD-SCPFRHCEAAL-----------------------------------------------------------------------------------------------------------------------------------NETVCTLWQEGRCFR--RVCRFRH------MEIDKKRSEICYWENQPTCQKLNCVFHHNRGR..................................................................................................................... 88
5 -25.000[R] COG5063 CCCH-type Zn-finger protein  ali follow..  18  158..................................................................................................................................................................VKSQVQETPKQLYKTELCESFTLGSCPYGS-KCQFAHGLGELKKSCKNFRTKPCVNWEKGYCPYRRCCFKHGDDNDIAVYVKAGTYCNVSSTSKQSDEKRSNGRGSAKKKNLNVKVKA.......................................................................... 279
6 -24.100[R] KOG1492 C3H1-type Zn-finger protein  ali follow..  16  248KVRWSLHNARLRLAKKKKYCQFFTRGKCNKDDGKCPYVHDPS-------KIAVCTKFLNGLCANANCKLTHKVIP---------------------------------------------------------------------------------------------------ERMPDCSYYLQGLCN--NEACPYRHVHVNP-------IAPICDGFLKGYCSELKCKLHHPKNQSKGRKRKRTNEPSQKNARRRYFSSLHNILSESEPMVFNRRSTDSEVFGMESLDFITLGTAEYEAGDDNDPATVQSISSDSESLISIYNLITPVALMHSRGFRFVTFKDEKSMKD... 504
7 -22.900[O] KOG1039 Predicted E3 ubiquitin ligase  ali follow..  17  4...............KQITCRYFMHGVCREGS-QCLFSHDLAN----SKPSTICKYYQKGYCAYTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIRSGLDDVEASSLCPYAAAGECRFG-DACVYLHGESVYWVEDQNKKNELCKYFEQGKCP-SKCLYRHAYPD..................................................................................................................... 351
8 -21.700[R] COG5252 Uncharacterized conserved protein, contains CCCH-type Zn-finger protein  ali follow..  12  2..................IMKKFL------SDELVKI----DNISFFNQCVLLFLESKGSHSISKPLGFTH-PPKKGKQAQAAGKKKDNVDKTFGMKNKNRSTKVQK-----------------IKQVQSQSDPKKEEMRLKKLEEKKRREAEEAERRALFNPVADQRVRAGVDPKSMVCALFKLGNCNKGAK-CKFSHDLNVGRRMEKKEAVENGKYGWFWICPNDKCMYRHSLPEGFVLKTNEQKRLERESLEK.................................................................................................. 272
9 -16.400[R] KOG1763 Uncharacterized conserved protein, contains CCCH-type Zn-finger  ali follow..  17  101...............KSVVCAFFKQGQCTKGD-KCKFSH----------------DLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEA--------------------------------------------------------------------EKKKPKTQIVCKHFLEAVCPGGGDICMYRHALPPGFVLKKDKKKE............................................................................................................................................ 224
10 -13.100[K] KOG2068 MOT2 transcription factor  ali follow..  10  1........MSDYGEKTCPLCAELK---CKCGYQICVW-HHIMDMAEKDQ--------SEGRC--PACRTPYDKEKIVGMTVDQERLASEGNMDRKKIQKSKPKSSDGRKPLTSVRVVQRNLVYIVGLPLNLADEDLLQRKEY--LKVSMSRTATGLIQQFPNNTCSVYITYGKEEEAIRCIQSVHGFILDGKA------------LKACFGTTKYCHAWLRNVCNNQDCLYLHEVGSQEDSFTKDEIISAHTRVQQITGATNTMQYRSGSMLPPPLDAYTSDSSTGNPIAKVPSSTSVSAPKSSPPSGSSGKSTALPAAASWGARLTNQHSLATSALS................ 321
11 -13.000[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  10  2..........................................................................................................................................SSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGDKVSGTC----ESCKFKR-------TVQNNKRYTCI--ENQNCQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYG. 216
12 -12.300[R] KOG0153 Predicted RNA-binding protein (RRM superfamily)  ali follow..  10  1MSKTTNTYNR-QNWEDAELCQTYVRMIKERFGKECKI------------------------CTRPFTIFRWCPGA-RMRFKKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDGTEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRG-EECPYRHDKPNENLPEEITEPELRDQFYQGEIRSQQCAFVQYTKRNAAELAKQGTAAKTDRRFDLAGIPPPSAKPNDYFNLRQEQINVMPAGMKLHQLPSNLVPASAYQMYGQPTYAAPYGNATSTALSSSGVNLDSISIPPPPGQVPYPSQDASRMGAVK. 415
13 -11.900[T] KOG3575 FOG: Hormone receptors  ali follow..  12  1.............................................................................................................................................MSPLKMHVNMLQSDHALIMSSFPEPSPSSKRPTENCKVCGDRPNNAC----LGCTFRR-------AVVKNLKYKCMK--EQNCYRNACRYCRFQKCFAVGMHSSAIQRRDLVGPRKISGDGEVIICENNTFLDDFASFQ.......................................................................... 139
14 -11.700[K] COG5175 Transcriptional repressor  ali follow..  11  17LSNFDTSFLSEDEEDYCPLCKNFF---CPCGYQICQF-N---NIRQNPE--------LNGRC--PACRRKYDDENVRYVTLSPEELKMERAKLARKEKERKHREKERKENEYTNRKHLSGTRVIQKNLVYVVGINPPVPYEEVAPTLKSEKKIVVNRKTPHSNNTTSEHYHHHSPGYGVYITFGS---KDDAARC-----MDGRLIKAAYGTTKYCSSYLRGLCPNPNCMFLHEPGEEADSFNKRELHNKQQAQQQSGGTAFTRSGIHNNISTSTAGSNTNLLSENFTGTPSPAAMRAQLHHDSHTNAGTPVLTPAPVPAGSNPWGVTQSATPVTSINLSKNSSSINLPTL... 371
15 -11.500[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  9  148............................QRGK--CTYFDKALEAQRLGFKGVIVGDNRSPSSFRLHYMVAPDKVDESKVHIPSLFVSTSSYNLLWSDLLHSYRQPLKLYAKPEELKFIRTYRTKSKTRRFIEDLPSRTISREGFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLEFTKGDKVV---PCKHEHRP--------------CIA-YRHAC--PTCNTEVPPPK..................................................................................................................... 370
16 -11.400[R] KOG3002 Zn finger protein  ali follow..  15  42.IGKFHSSNGVYELLECPVCTNLMY-QCPNGHTLC----------------SSCKLRVQNTC--PTCR------------------------------------------------------------------------------------------YELGNIRCLALEKVAESLEVPCRYQNLG-CQD-EQHCRF--------------RSYSC-------YAGSECSVTH......................................................................................................................... 164
17 -11.400[R] KOG2333 Uncharacterized conserved protein  ali follow..  9  18.....................................................................................................................................................KQDGNKKRKRKERGQNKRREKIHVKENNALCPAISIGECPYKEN-CKFPHDVEAYLATKAPDIGDKCPIFRYGVCPAGKCRWLHVVINADGKYELIKKPDGQFTLFTVNTVGKEVQRKLRTKQLDLSKAESIISAVLGEEKPDPSSKVSNIPEENRDATSAISEGKETESVSLEETGVLKNQTVSVNVDLKEISSQARSNIALP. 225
18 -11.300[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  7  322.....................................................................................................................................................RNNKQLDDTLVTVTVEQLQNSANDDNICIICMDLIHSPNQQTWKNCGHIHLS--------------CKNWMEQTC--PICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLT.... 520
19 -10.200[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  11  260.....................................................................................................................................................EEAKIRERLDTERRERRARSRPHTLSQDQLCV------CSTNPKEC--GH--------------EDCAQKISVTC--PVCR............................................................................................................................ 326
20 -10.200[K] KOG4216 Steroid hormone nuclear receptor  ali follow..  6  1...............................................................................MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARSSSTCSSLSRLFWSQLEHINWDGATAKNFINLREFFSFLLPALRKAQIEIIPCKICGDKSSGTC----EGCKFRRS-------QQSNATYSCPR--QKNCSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTP. 274
21 -9.850[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  10  6LNINQASGSKINTELAVPI---FQSRRRHRPRQGLKRKKGFKRDDDSGGSSESSNEDMRDN-TVRLNRLQRESEQFENSALKDINVEYQSNLSATGESVNTTTVSAINEDTREVILGRPSPKLANQSTLPTELFQSQNDYSRFLPKRKDFEKKSQVGPVLSSNASTVRMNTIIDYQPDVCKDYKLGYCGYGDT-CKFLHMREDYKAGWQLDRELICKKDYRSTCGHHFCE............................................................................................................................ 275
22 -9.840[A] COG5200 U1 snRNP component, mediates U1 snRNP association with cap-binding complex  ali follow..  9  30....YSHQKRDLGLHDPKICKSYLVGECTKQSGKCPQMHLTKHKIQYER---------EVKQGKTFPEFEREYLAILSRFVNECNGQISVALQNLKHTAEERMKIQQVTEELDVLDVRIGLMGQEIDSLIRADEVSMGMLQSVKLQELISKRKEVAKRVRNITENVGQSAQQKLQVCEVCGAYL----SRLDTDRRLAH--------------------FLGKIHLGYVKMREDYDRLMKNNRTTNASKTATTLPG.................................................................................................. 257
23 -9.410[R] KOG3394 Protein OS-9  ali follow..  10  186.................TMCRT-VRYVCYPHGKNCNYE-----AIILSSAL---------------CPLHAEETKELSIQCFNSESKPHRPLSMLRSELKEWVESEADLLVFKEKATENLWPKTDGDLVTLNYGGDMEKVLLEHFRNGDLKVDGDFQQLLLSIAASETGPTPITDLTPLKDFISGKNCLTGGNGCQF-HKDKTSEVELFLGY-THC---QIGVCTPKTCQYILIHNADSQGLVKLENLDKILVTETDKSTTSSASAPAPAPTSSTDEENHP......................................................................... 525
24 -9.320[O] KOG0802 E3 ubiquitin ligase  ali follow..  8  347..................................................................................................................................................................PDATSEELRAYDDECAICREPMAKA------HCNHLHLG--------------CRSWLD-SC--PTCR--------KPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAA. 518
25 -9.310[S] COG3369 Uncharacterized conserved protein  ali follow..  10  40HTRELIDIKEYPRRESYILCR------CGSSENKCDGTHSKIGFDGSETASRKPYMEKAETVEGPDLKLTDAPE--------DHSRFCQRSGGIRDLIQKSDDPEARQTAIEEAMICPSGRLVLWDKKTGKPFEKEFEPSIVLVHDKQKNCEGPLWVRGGIPIESADGSMYESRNRVTLCR------CGKSENKCDGSH........................................................................................................................................................... 224
26 -9.200[R] KOG1667 Zn2+-binding protein Melusin/RAR1, contains CHORD domain  ali follow..  13  4..................LCY---NRGCGQSDDACTY-HPGVPVFHDALKGWSC-------CKRRTTDF-------SDFLSIVGCTKGRHNSEKPPEPVKPEVKTTEKKELCELKPKFQEHIIQAPKPVEAIKRPSPDEPMTNLELKISASLKQALDKLKLSSGNEENKKEEDNDEIKIGTSCKNGGCESLEEVCVY-HSGVPIFHEGMK---SCCR......................................................................................................................................... 196
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.