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Query: [R] KOG2501 Thioredoxin, nucleoredoxin and related proteins, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSTNVMQVLVSKLVGKTIGLYFGAHWCPPFRSFTSQLVDVYNELATTDKGSFEVILISTDRDSREFNINMTNMPWLAIPYEDRTRQDLCRIFNVKLIPALVIIGPEEKTVTTNAREMVSLYGSRSFPFTESRIVELKACLKKEGDSLPRKVKDNKHEHELKLDMAKAYVCDFCKKQGRFWAFSCNACDYDLHPTCVEEEEALLVLast
1 -94.900[R] KOG2501 Thioredoxin, nucleoredoxin and related proteins  ali  100  1MSTNVMQVLVSKLVGKTIGLYFGAHWCPPFRSFTSQLVDVYNELATTDKGSFEVILISTDRDSREFNINMTNMPWLAIPYEDRTRQDLCRIFNVKLIPALVIIGPEEKTVTTNAREMVSLYGSRSFPFTESRIVELKACLKKEGDSLPRKVKDNKHEHELKLDMAKAYVCDFCKKQGRFWAFSCNACDYDLHPTCVEEEEALLV 204
2 -23.000[O] KOG0910 Thioredoxin-like protein  ali follow..  17  81......EIGESEFSSTVVLVEFVATWCGPCKLIYPAM----EALSQEYGDKLTIVKIDHDANP-----------------------KLIAEFKVYGLPHFILF-KDGKEVPGS........................................................................................... 165
3 -21.500[O] COG2143 Thioredoxin-related protein  ali follow..  17  68.....SDNKSISPNDKYMLLVFGRNGCSYCERFKKDLKN--KELRDYIKEHFSAYYVNISYSKE---HDFKVGDKNNEKEIKMSTEELAQIYAVQSTPTIVLSDKTGKTIYE............................................................................................ 170
4 -20.600[R] COG3054 Predicted transcriptional regulator  ali follow..  8  46.EFSYKNWNSAQLAGKVRVLLHIAGRTSAKEKNATLIEAIKSAKLPHDR--YQTTTIVNTDDRSSIESNKKLYPWSQFIVDSN--GVARNAWQLEEGSAVIVLDKDGRVQWVKDGALTQQEVQQVVDLLHKLLSK..................................................................... 185
5 -18.200[S] KOG2640 Thioredoxin  ali follow..  10  176LNMSQDLMDFLNPNGDCTLVLFYTPWCRFSASLAPHFNSLPRAFP-------ALHFLALDASQHS---------------------SLSTRFGTVAVPNILLF-QGAKPMARFNHTDRTLETLKIF-IFNQTGIEAKKNVVVTQADQIGPLPSTLIKSVDWLLVFSLFFLISFI.............................. 320
6 -17.800[O] KOG0907 Thioredoxin  ali follow..  13  80.SGEEFDVALKNAKSKLVVAEFATSKSDQSNKIYPFMVELSRTCNDV-----VFLLVMGDESDKT--------------------RELCRREKIEKVPHFSFYKSMEKIHEEEGIEPDQLMG----DVLYYGDNHSAVVQLHGRPDVEKLIDENRTGGKLIVLDVGLKHCGPCVKVYPTVLKLSRSMNGDENDSCMEFLKDMNV 262
7 -17.500[AD] KOG3414 Component of the U4/U6.U5 snRNP/mitosis protein DIM1  ali follow..  6  22.............EERLVVIRFGHDWDETCMQMDEVLASVAETIKNF----AVIYLVDITEVPD-----------------------FNTMYELYDPSTVMFF--RNKHIMIDLGTGNNNKINWALKDKQEFIDIIETVYRGARKGRGLVIAPKDYSTK............................................. 139
8 -17.300[S] KOG3425 Uncharacterized conserved protein  ali follow..  14  11.............QRSPIYIYFYGEWCPDCVAAEETIMSAFRNHAPAD---CMILVVDVGSRES---------------WIGKDNMFRKPPYSVEGIPTLIRWKGVERLDGDQLLK........................................................................................ 102
9 -16.900[R] COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems  ali follow..  16  66TDGEGKPFNLSDLKGKVVILSFGFTHCPDCPTELLTYSDTLKQLGGQA-KDVKVVFVSIDPERDTPEIIGKYAK-YRVVSAKVNQKDDSENYLVDHSSGAYLIDKNGEVAI............................................................................................. 198
10 -16.000[O] KOG0908 Thioredoxin-like protein  ali follow..  16  8.DESHFQAELAQAGIQLVVVDFTASWCGPCKRIAPIFETFPTKYP-------KAIFLKVDVDK---------------------CQDTAAGQGVSAMPTFIFYRNRTKIDRVQGAD........................................................................................ 94
11 -16.000[O] COG0450 Peroxiredoxin  ali follow..  12  17KDGKFVTVSEADVKGKWSVFFFYADFTFVCPTELEDLADNYDVFTRLG---VEIYAVSTDTSHKAWHDSSPAIGKIKYTMVGDPSGQVTNNFEI-ADRGTFLVDPQGVI............................................................................................... 131
12 -15.600[S] KOG4498 Uncharacterized conserved protein  ali follow..  9  77LDLRGNEIPISDLDRKAVVAFARHFGCVLCRKRAAYLAEKKDVMDASG---VALVLIGPGSIDQA--NTFVEQTKFKGEVYADPNHASYEALEFVSQGGILVAGPGKDNIS............................................................................................. 225
13 -15.400[O] COG1225 Peroxiredoxin  ali follow..  17  16.ATSGLTFSLAGQRGKVVVLYFYPKDNTPCTTEAMNFRDQYDAFEAAD---AVVFGISRDSLKS--HENFKAKLELPFELLSDADEAVCALFDTIKERSTFLIDRKGVLR.............................................................................................. 132
14 -15.300[O] KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes  ali follow..  18  65VNKEIVKLSLSQYLGKYVVLLFYLDFTFVCPTEIIAFSDRIAEFKKIK---TEVIGVSVDS-------HFTHLAWVKIPLLSDLTHKISKDYGVHALRGLFIIDQTGVLVGRSVDETIRL--VQAFQYTDTH........................................................................ 212
15 -14.600[O] COG3118 Thioredoxin domain-containing protein  ali follow..  20  12.GANFEQLVIENSFHKPVLVDFWADWCAPCKALMPLL----AQIAESYQGELLLAKVNCDVEQ-----------------------DIVMRFGIRSLPTVVLF-KDGQPVD............................................................................................. 93
16 -14.500[O] COG2077 Peroxiredoxin  ali follow..  10  30VSAKLEDTTLANFAGKRKILNIFPS-TGICATSVRKFNEQAAKLAN-----TAVLCLSTDLPFAQARFCGAEGLENVFTVSTFRNKDVHKQLGV-TARAVIVLDENNRVLHSELVPEIKQ.................................................................................... 154
17 -13.600[R] KOG4277 Uncharacterized conserved protein, contains thioredoxin domain  ali follow..  10  33LSDKFLDVK----DEGMWFVEFYAPWCAHCKRLHPVWDQVGHTLSDSNL---PIRVGKLDCTRFP---------------------AVANKLSIQGYPTILFF-RNGHVIDYRGGREKEALVSFAKRCAAPIIEVINENQIEK............................................................. 146
18 -13.300[O] KOG0855 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes  ali follow..  10  76.NEDNDSISLKKITENVVFFVYPRASTPGCTRQACGFRDNYQELKKYA----AVFGLSADTSQKKFQSKQ-NLPYHLLSDPK---REFIGLLGASGSIRSHFIFVDGKLKFKRVKISPEVSVNDAKKEVLEVAEKFKEE................................................................. 215
19 -12.800[OC] COG4232 Thiol:disulfide interchange protein  ali follow..  15  455.TVDELNQALVEAKGKPVMLDLYADWCVACKEFDPQVQKALA----------DTVLLQAN-----------------VTANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQ............................................................................................ 544
20 -12.700[O] KOG0191 Thioredoxin/protein disulfide isomerase  ali follow..  18  26QSLNELENTIRA-SKKGALIEFYATWCGHCKSLAPV----YEELGALFEDHNDVLIGKIDADTH---------------------SDVADKYHITGFPTLIWFPPDGSEPVQRDVDSLTQFVSEKTGIKKRKIVLPSNVVELDSLNFDKVVMDDK---KDVLVEFYADWCGYCKRLAPTY........................ 180
21 -12.700[C] KOG2792 Putative cytochrome C oxidase assembly protein  ali follow..  14  289VSTENKIVTENDFCGKWVLLYFGYSFSPDGPEQLKMMSKA-----------VDKLAILLNPLTFGCLYLYAEFDILGLTGTASAMRQMAQEYRVDTSHNMYLINPKMEIVRCFGVEYNPDELSQEL.............................................................................. 420
22 -11.800[OC] COG0526 Thiol-disulfide isomerase and thioredoxins  ali follow..  12  361VADNFDDIVMDE--TKDVLVEFYAPWCGHCKNLAPTYEKLAEEYSDDS----NVVVAKIDATEND------------------------ISVSISGFPTIMFFKANDKVNPVRYEGDRTLEDLSAF--ASFEPIKKEKESVPAPDLEDQVAVEDEMADEL............................................ 492
23 -11.600[O] COG0678 Peroxiredoxin  ali follow..  8  25NPYRWEDKTSDDFRGKRIILFSLGAFTPTCTLQLPDFEMLYDEFEKEGID--AIYCVSVN-DAFVMNAWGKALGLQKVQLIPDGSGEFTRKMGMMRSWRYAAVINNGVVFEEDGFCDNCEADPYGVSSPQNVLETLRAAKAVTAA........................................................... 182
24 -11.500[O] KOG2603 Oligosaccharyltransferase, gamma subunit  ali follow..  12  55.GPKFREYVKSAPRNYSMIVMLTALQCQICRHAHDEFAIVANSYRFSSTYSNKLFFAMVDFDDG---------------------SEVFQLLRLNTAPVFMHFPAKGK................................................................................................ 144
25 -11.300[S] COG4312 Uncharacterized protein conserved in bacteria  ali follow..  15  53.TASGKKTLADLFDGRSQLMIYWAAGCPGCSLVADHLGGTLAHLNHHD---VTLIAVSRA-PLPEIEAYRQRMGW-QFPWASSFGTTFNHDFRVSPGLSAFYKDEAGNVYHT............................................................................................ 192
26 -10.800[O] KOG1651 Glutathione peroxidase  ali follow..  15  19.DSSGKDLNMSIYQGKVLLIVNVASKCGFTETNYTQLTELYRKYKDQD---FEILAFPCNQEAHEFACERFKAEYPVFQKVRVNGQNAAPIYKIKWNFTKFLVGKDGLVIDR............................................................................................ 149
27 -10.700[O] KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit)  ali follow..  6  4.............SSTSISLLLFVSFILLLVNSRAE----NASSGSDLDEELAFLAAEESKEQS---------------------HGGGSYHEEEHDHQHRDFENYDDLEQGGGEFHHGDHGYEEEPLPPVDEKDVAVLTKDNFTEFVG-------NNSFAMVEFYAPWCGACQALTPEYAAAATELKGLAALAKIDATEEGDL 162
28 -10.400[OC] KOG1672 ATP binding protein  ali follow..  10  69REVSEGDFLGEVTRSEKVICHFYHKEFYRCKIMDKHLKTLAPRHV-------DTKFIKVDAENAPF---------------------FVTKLAIKTLPCVVLF-SKGVAMDR............................................................................................ 151
29 -10.300[S] COG4243 Predicted membrane protein  ali follow..  13  220STSGEAEIALAQHLVKVGAKEYVAYWCPHCHDQKLLFGKEAYQIISDNI---KVECAEDSPKGQP---------------------ELCRAAKIQGFPTWIINGQSGVQNLSELAKITGYTGPSNF.............................................................................. 323
30 -9.670[O] KOG0541 Alkyl hydroperoxide reductase/peroxiredoxin  ali follow..  12  21.NDQLQTVSVHSIAGKKVILFGVGAFTPTCMSHVPGFIGKAEELKSKGID--EIICFSVNDPFVMKAWGKTYPENKHVKFVADGSGEYTHLLGLRSRRFALLLD-NLKV............................................................................................... 139
31 -9.640[O] KOG0911 Glutaredoxin-related protein  ali follow..  13  5VKDIVSKAELDNLSGAPVVLHFWASWCDASKQMDQVFSHLATDFP-------RAHFFRVEAEEHP---------------------EISEAYSVAAVPYFVFFKDGKTV............................................................................................... 87
32 -9.580[O] COG0386 Glutathione peroxidase  ali follow..  14  10.DAEGNAVDLSGYRGKVLLIVNTATRCGLTPQYE-ALQKLYAQYTAEG---LEILDFPCNQFREQAPESSGEI-----------AQVCMMKFGTK-FKIFDKIEVNGA................................................................................................ 100
33 -9.380[O] COG1651 Protein-disulfide isomerase  ali follow..  13  124..PLDKAIKEVRGNGKLKVAVFSDPDCPFCKRLEHEFEKMTDGLHPDAARKAQILWCQPDRAKAWTDWMRKGKFPVGGSICDNPVAELGEQFGFNGTPTLVF--PNGRSQS............................................................................................. 244
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rodrigues AP, Grant BJ, Godzik A, Friedberg I. The 2006 automated function prediction meeting. BMC Bioinformatics. 2007 May 22;8 Suppl 4:S1-4.