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Query: [A] KOG2548 SWAP mRNA splicing regulator, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MWHEARKQERKIRGLIVDYRKRAERRQYFYDKIQADPTQFLQLHGRRSKIYLDPAVAAAGDGAAIMQGQQDNLIDRFDVRAHLDHIPPVNKTNAEGADGDSELTLEERQLNYERYRILAQNDFLNVSEDKFLHQLYLEEQFGANAQLEAERNLAKKKQKTGGATIGYSYEDTGDGATIGPQPFGAASSTVIGGAAAVAKGEKGDGSEESDSDIDMDVSIDIGKLDTSQAHELNACGRNYGMKSNDFFSHLTKDADEADALRIAREEEQEKMLLSGRKSRRERRAQKERRIANRPFSPPSYAAKEDKDKKGGGKGGEKEKEEDSESRSPSPAEAGPEKITYITSFGGEDEMQPHSKITISLTKPGLTLGESCINASSGAAIAAAAASSVSYAQKVKDNLDKLKVMNESSKRNRRRSRSHSRSRSRSATVSRSRSGSRRSGSRRRSRRSRSYHRRSRTRSRRRRRYYSRSRSRSRSRSRSLSRSRSRSRSRSRSGSWKRYKARSPSYKRSRKRYSYSSRSSSGSSYRRRSRSRSPSNRRSRVKKKTTPPPVATVGGYCLNTTTTTTTSTVTAVKMFQQQQQQPPAKATPPMISYPIPARMLNVNQALTATAPVAVQPQVVEPPPPPLKRYYGRKRGNDTSSSSSSGAENSEGSDNEEQQQPQLGKRAEDSDDMELDTASERSHALQPTMSSSSSTGNQTGKYSSATETGSGHPSSGGGGRPNLRERLKRKMQNLLNRQYKADKRAEIEKTERERLQQQEREDEMRELALKLRRRRRELRHKYGTPSSGKLSDSDAESVASESQLAKSSTRRSRSRSESRRRSPPPETQHSRRSSSRTERRRRTRTPSPKYNRRQRSRSRSGSRVERKRRSHSRRRSGSRDRRRSRSRRSQSRRRRQRDRSIERNREREQYRQQHQQQNERLRGRDRDREADYGHGGSGSSNRGRVVISAPPKLKKLVDYLast
1 -132.000[A] KOG2548 SWAP mRNA splicing regulator  ali  100  1MWHEARKQERKIRGLIVDYRKRAERRQYFYDKIQADPTQFLQLHGRRSKIYLDPAVAAAGDGAAIMQGQQDNLIDRFDVRAHLDHIPPVNKTNAEGADGDSELTLEERQLNYERYRILAQNDFLNVSEDKFLHQLYLEEQFGANAQLEAERNLAKKKQKTGGATIGYSYEDTGDGATIGPQPFGAASSTVIGGAAAVAKGEKGDGSEESDSDIDMDVSIDIGKLDTSQAHELNACGRNYGMKSNDFFSHLTKDADEADALRIAREEEQEKMLLSGRKSRRERRAQKERRIANRPFSPPSYAAKEDKDKKGGGKGGEKEKEEDSESRSPSPAEAGPEKITYITSFGGEDEMQPHSKITISLTKPGLTLGESCINASSGAAIAAAAASSVSYAQKVKDNLDKLKVMNESSKRNRRRSRSHSRSRSRSATVSRSRSGSRRSGSRRRSRRSRSYHRRSRTRSRRRRRYYSRSRSRSRSRSRSLSRSRSRSRSRSRSGSWKRYKARSPSYKRSRKRYSYSSRSSSGSSYRRRSRSRSPSNRRSRVKKKTTPPPVATVGGYCLNTTTTTTTSTVTAVKMFQQQQQQPPAKATPPMISYPIPARMLNVNQALTATAPVAVQPQVVEPPPPPLKRYYGRKRGNDTSSSSSSGAENSEGSDNEEQQQPQLGKRAEDSDDMELDTASERSHALQPTMSSSSSTGNQTGKYSSATETGSGHPSSGGGGRPNLRERLKRKMQNLLNRQYKADKRAEIEKTERERLQQQEREDEMRELALKLRRRRRELRHKYGTPSSGKLSDSDAESVASESQLAKSSTRRSRSRSESRRRSPPPETQHSRRSSSRTERRRRTRTPSPKYNRRQRSRSRSGSRVERKRRSHSRRRSGSRDRRRSRSRRSQSRRRRQRDRSIERNREREQYRQQHQQQNERLRGRDRDREADYGHGGSGSSNRGRVVISAPPKLKKLVDY 957
2 -15.800[A] KOG2217 U4/U6.U5 snRNP associated protein  ali follow..  15  3..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSSSGKKHKKDKKNRHRSRSSERPRRVTEDEDVTLDLTDDSSSRHRHHKHKKHKEHRHKHHKQKERERANEVISLEESDSDSSDCVEVPVQAQVQAQAKLRDARESSNRDKERDSGRDRELLRERERERDRERERDRDREKEREREREKERLRE-REEREREREKERIREREKERLRERERERERERVRELTAPPPPQISKHAEYESRREREIERERDARKRSGRERERERNRERSRSQSPASSSRKPATKEREPSSRSFSPIPENGAGDVLSITETNKLRAK.... 284
3 -13.900[R] KOG2140 Uncharacterized conserved protein  ali follow..  9  655................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VAQKPDVEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKKGHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRDPITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRIKDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRREKSPAKQK............... 908
4 -12.700[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  12  453..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SRNRTVSSSAIARAVSDAAAGEYSSAIETLVTAISLIKQSKVAHDER-QDTLHGIEAKSYNRRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGRSVRPRKSPEPVVAEAAEAPSSKRYYEDRERYRSSDR-----ERRDRDRDRDRERERDRDRHFTNDGRGLPLDPSNFTSQNPGNIKTGRPKSAAVAGGSMEKPRGQSAWDIIDTDAHWIIKQQTTSIPAPPSSQQNF 697
5 -12.600[S] KOG4610 Uncharacterized conserved protein  ali follow..  12  299.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KNSLVIILQLYRLYVVNAEFWKNRRESRMAKSRQFQSRRKVQDADQNSIYMISNERGGDVKKKIKRAKDKDYAEQEAVYSKKKKDKKDKKKRKRKDTGYSTASSQNLYSTKASGTDKDTRRKDKKGKKSKRTCSSSPSDCDLAKKQKRKNADKNDKKKSRKIEAVVEESSSSSSSSSDSSNSTLPSYEVIDEKKARRRKHRGSSSDTSSGDSSSSSSSSSSSDSS....... 523
6 -12.500[O] KOG0314 Predicted E3 ubiquitin ligase  ali follow..  12  507.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GREEFEAKKTEMKRKRENEIRRSEGGNVVRDSEKSRIMNNSAVTSSPVKPKSRQGPPPPISSDYDRRRRSDRSSPERQSSRRFTSPPRSSSRKSERDRHHDLDSEHDRRRDRPRETDRKHRKRSEKSSSDPTVEIDDNNKSNVFTRISFPEESSGKQRKTSKSSPAPPESSVAPVSSGRRHHSRREREMVEYDSSDDEDRHFKRKPSRYKRSPSVAPSDAGDEHFRHSKRSKGERAR............... 743
7 -12.400[A] KOG4676 Splicing factor, arginine/serine-rich  ali follow..  11  192............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................STVDPKLNHVAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEED. 479
8 -11.700[P] KOG4505 Na+/H+ antiporter  ali follow..  10  439...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RINTLALSFTRTRDSHFAFNLPRVRQGQSLPIKRVDALRSSANSIASSIRRRHPVNIQEDEDADISTVSLPEAAHLREERAESPRGGHYDAEEFPSEDYESRQPRRSNEEDREEEMNPGDETYLIGEDLVVEDSQGNIISHTSSRDANGPSIDEKLAQGDPKAKSFGRKFRSFLRRSYDTFQRNLHEPDDERQREPTLGHIESSIENHRPRYSRQNSESHLRENSVERRRREQVLTNIGDSESEDDNIPRPGIVPFYNENNESSSDTRNGLLSDNVSESRSRRPSRAPSAAVSSEGSPVEEDNEAQHRPNIRFLELTRAWE......................................... 759
9 -11.300[TU] KOG3895 Synaptic vesicle protein Synapsin  ali follow..  10  312...................TARLENQSAL-----QDAAGLVSGAGNDSHCYCTIE-----------------YIDKFSVH--IQKIGN----------------------NYKAFRKSITGNWKTNQGSAMLEQITLTEKYKSWVDEISE----------------------------------------------------------------MEV---LSVVVAKD-------GREYIISACDSTFALIGDTQEEDRRQIADLVSGRMQNVCRPSMAQ---------------TGPGKLPSRSSVSSRAESPTDEGVAPTPPLPAGPRPAPMGGPPPIPERTSPAVGSIGRLSSRSSISEVPEEPSSSGPSTVGGEIANKKRGRTASETSSGSGPGSVPSSAGPGSGFSSSFLGKQFSFAGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSVSDSRNTDTLTERAGAGYQPVTNYEQQERVNPFDKEPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAGPPPPPPTNVTAVGSNANSSSGYRNSFSSSLSKDKTSYGNYGSTTSVETITRMDTNTTNIGATATEAGEASGVTAITNISNSDGIVAPTTGTITTSVTTNDWRSAIGMRSASVYSAPAAVTTVLPGDTSGYDSNSIASQGEGLNNPSDLPSYTRPSYSRSESNASKHSDLDVIFGDSKTTPASYGNGKYTRAAGSISDADMIFGGPPSNYKTDRFGASKSMSMTSGGVGSGNGSGSGLGGYKIYDSIQNAAFSDFSDSGSMSSIGSHTKRWSASKEEDDE............................................................................................................................................. 982
10 -10.500[R] KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains  ali follow..  12  7..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NADDDGKRVQNEEGNYDPTDHQRQMEDYYKQYEEQRQVANSFHNTTGRPDLVAMQARLAETEQAIHRLNEEKKQPPPGFPIMTTPATQPEISIPRSGENKSSRSPSWAREARRSRSRSRDRRGGRSRSRSPSRRRTSRDRRDDRSSRRRRDRSHSRSRSPPSSANGSSHWSSSNRHSRRRRSRSYSRERDRNSRRDDRRSNLSNNDRYSDWNPGVPSN......... 224
11 -10.200[A] KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily)  ali follow..  10  221.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RYRLEREREDREGPGRGGGSNGLDARPGRGFGAERRRSRSRERRDRERDRGRGAVASNGRSRSRSRERRKRRAGSRERYDEFDRRDRRDRERERDRDREREKKKKRSKSRERESSRERRERKRERRDRERGTGSGGDVKERKPDFRDMDVIKIKEEPVDDGYPTFDYQNATIKREIDDEDEEKYRPPPAHHNMFSVPPPPILGRGNASTNPNPDNGQQSSGDPSWWRQ.... 448
12 -10.200[S] KOG4843 Uncharacterized conserved protein  ali follow..  7  101.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SRTVVKVARSEPRDGERRSPLPLVYRSPSLPTTVSSSDPHLTHAPVPMEPRDGAKDGREIRVESRENRSDGREIYGETKREIQGPKGDRDVKFERSVDDFSGKGNTGSYTRNDGREMYGETKREIQGPKSDRDAKFERPGDDFSGKSNAGSYTRDTKFDRENQNYNEQKGEIKMEKEGHAHLAWKEQKDYHRGKRVAEGSTANVDPWVVSRGNPQGPTEVGPKDLSAPVEGSHLEGRETVGENKVDAKNEDRFKEKDKKRKELKHREWGDRDKDRNDRRVSVLVGSVMSEPKEIGREERESDRWERERMEQKDRERNKEKDKDHIKREPRTGAEKEISQNEKELGEASAKPSEQEYVAPEQKKQNEPDNCEKDERETKEKRRERDGDSEAERAEKRSRISEKESEDGCLEGEGATEREKDAFNYGVQQRKRALRPRGSPQTTNRDNVRSRSQDNEGVQGNHSFLYPQERIKLHCLENNSKSEVSI. 585
13 -9.980[K] KOG3794 CBF1-interacting corepressor CIR and related proteins  ali follow..  8  327.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SDKKRKSKKNKRHKKHSSRTVEETDESSTGSEDSREKRGSKKRKKLKKKSKKQYDSDSLSFEGSGSDSYRLSRRRHTKHVDPSASLKSEVYHQGNSHREKHYYDEKHQKRKEIVDRPSASSDDSDYYRSNSSRKKRSEDDYKSHHRERKQVHSNDPVSEKSQKQHYSESGKIQRVEKEHRYDERRHRYVDMESENRNRSEKKPRYDDRDSEKHHRSVKGKEKHVYEASDDPEEFSDRYRSTKKTESDSESNRRSRKKKHELSSEEEEGESRVIGEQVRKSMSLIHRRLYRISGLSSVNAWNLQIREAVNRNDPVESLLLFREMKR. 651
14 -9.660[R] KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains  ali follow..  11  756.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PTSRWAREDDETDDEQKKSYSSGSDNAGGITFKTDEEDLKADPSVRVQPENEIDVEQRQKLRHIEIALIEYRESLEEQGMKNSEEIERKVAIHRKRLEADGLSGNQRVLPEKREKREDSRDSSRKRNRSESQNRSQSPPQKSL-TRERVRDHDLDKDRHRDRDRQQHDLDKDRKRRAKSSSRERDDHDRSRERDRDWRRRGMR................. 957
15 -9.590[R] KOG2888 Putative RNA binding protein  ali follow..  14  204.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KQIEKRIEQYCREQGVTVHQLSTGRSTAGTGGGPGAAGQDADYQDYPEGGVERGSGGRGGGQAGSRSNAYPQPNNYRNDYDERDYYAAASGSSYGRGRGGYEDYPPAPLPPQMPYGERERERDRDRDKNKDYDRHRSKHKKKHNHRQSSRSRSRSRSRSRHRSERHERKRDGGGYERSSKSRHNEHYEERERRHR......................................... 398
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.