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Query: [BK] KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRSSKGGRGRQAAPKTAPTTVCYCDGKRELGSVEVVCSTCLKWFHGRCLKEFHEFSRNSNGVPFMICYTFTCKQCRPTAEDWKAKKADLVQMCVTVLATLSAERLKADGKLSAEHVPEDFTYLSLKDEIVPYMNENWYMLTAIKQKKEWHQNLAPTLLKEKNIFVQHNDDDDLFALAEKNLSLLGPLHEAVKLIGKRPIERENREPRHIELPPIEGPKTRGASKRRHAEAPVTGKKQKLAADYSSTAAPNGVQIDIPFSKDNYRYYLTEVDPNVPEDPAWNQNQSSAYVIPSFHYRELLNPTVNVSSNDRAFQLSINGNSITGFEGYSMARASHGVSKGTWYFEVNFDDQPDDSHIRIGWSQSYASLQACVGYNKFSYGWRSKHGTKFHEAKGKKYHFGGFKQGDVLGCLIHLPVDKKLQIPANLPSEKYLPVSHKGFNLISFKANYFFEVQEESADIAKTLVEMPGSYIEFFHNGKSCGKAYENIYAGAYYPSISIFKSATATMNLGPKFRNLPRGATGIHARADEQQHEQTLSDMLYLVSKEVNLDHPPRVKREDDDDVKDIKKEIKQEILast
1 -161.000[BK] KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2  ali  100  1MRSSKGGRGRQAAPKTAPTTVCYCDGKRELGSVEVVCSTCLKWFHGRCLKEFHEFSRNSNGVPFMICYTFTCKQCRPTAEDWKAKKADLVQMCVTVLATLSAERLKADGKLSAEHVPEDFTYLSLKDEIVPYMNENWYMLTAIKQKKEWHQNLAPTLLKEKNIFVQHNDDDDLFALAEKNLSLLGPLHEAVKLIGKRPIERENREPRHIELPPIEGPKTRGASKRRHAEAPVTGKKQKLAADYSSTAAPNGVQIDIPFSKDNYRYYLTEVDPNVPEDPAWNQNQSSAYVIPSFHYRELLNPTVNVSSNDRAFQLSINGNSITGFEGYSMARASHGVSKGTWYFEVNFDDQPDDSHIRIGWSQSYASLQACVGYNKFSYGWRSKHGTKFHEAKGKKYHFGGFKQGDVLGCLIHLPVDKKLQIPANLPSEKYLPVSHKGFNLISFKANYFFEVQEESADIAKTLVEMPGSYIEFFHNGKSCGKAYENIYAGAYYPSISIFKSATATMNLGPKFRNLPRGATGIHARADEQQHEQTLSDMLYLVSKEVNLDHPPRVKREDDDDVKDIKKEIKQEI 572
2 -48.500[R] KOG3138 Predicted N-acetyltransferase  ali follow..  14  3.........RPSNWDDPQGPCRYCESPVEDDN-YLECQECRRMVHIKCLPHACT----PGDLLGDVFFEFTCVKCVLIKEVIVRQRIPWLLVLTLTLYNLSIKQ----------KGLGHHGFFHWRTHIISFVDKNWNYIFNVRRRKQWTGSVSGALSHNSPEYFQSGLDVFQENGWWKLAKPFQTPRSVLKEYEKKQQLRLQMRIEKRLPAADETSCSSEISVADHAQDNPPLIKAEAEKPSSTEGCARTIPYMGRLPK........................................................................................................................................................................................................................................................................................................................ 254
3 -36.100[A] KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain  ali follow..  13  1.........................................................................................MDVRRLKVNELREELQRRGLDTRGLKTE-------LAERLQAALEAE-RELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYP-WSGARASYGVRRGRVCFEMKINEEPDPHVVRIGWSLDSCSTQ--LGEEPFSYGYGGTGKKSTNSR--FENYGDKFAENDVIGCFADFECGN-------------------------------------------------DVELSFTKNGKWMGIAFRIQKEALLYPHV-LVKNCAVEFNFGQAEPYCSVL....................................................... 394
4 -35.000[S] KOG4030 Uncharacterized conserved protein, contains SPRY domain  ali follow..  19  23.......................................................................................................................................................................................................................................................................................................KEMPAVQLDTQHMGTDVVIVKNGRRIC---GTGGCLASAPLHQNKSYFEFKIQS---TGIWGIGVATQKVNLNQPLGRDMHSLVMRNDGALYHNNEEKNRPANSLPQEGDVVGITYD------------------------------------------------------HVELNVYLNGKNMHCPASGI-RGTVYPVVYVDDSAILDCQFSE-FYHTPPGFEKILFEQQ.............................................. 194
5 -30.700[R] KOG1477 SPRY domain-containing proteins  ali follow..  13  74............................................................................................................................................................................................DDESEYDEENALGTRTSGTLHSLFGKKHSGILLDSSFASPGGFDDEIVLQERELEELPKMSAYEVELYIRAKEFQMMSPPMVKDFGTYLDSDDQQFIKDRGIQSYFLLPSINDNIDEYGNFLPSFIVQDKLDIQKFNKSSSTVMNYPLRKDAVYFEVKIFRHIQNSIFSIGLTTVPYPYFRVPGMAKYSIAYESTGKLRINNPFTASTLLPKLEEGDTVGFGYRYKTGT----------------------------------------------------IFITHNGKKLMDVTQNI-GIDLFIGIGA-FNAAYTRTYTRDLLEDPDNVSFREALSEGKDIEVA....................................... 372
6 -22.900[R] KOG3953 SOCS box protein SSB-1, contains SPRY domain  ali follow..  15  66.............................................................................................................................................................................................................................................................................................................TWSKRHRSKEVVLRGPNSRTNWSKGTAGVQGKRSLNNGRHYWELHVSQRVFGTSIMFGIGTKSARLHA-LGENEHGWGL-SHKGVLWHEGVALLYTKRRENQPTQIGVLFDGIEGT----------------------------------------------------LTFYKDGKCLGVAFRGLIDEPLYPIVCSAAKTEMTL---------------CTRREFVNLQDRCRAVIMRRVRSAAQLEKLKLPLPIADYLSEVINYDILCDL 293
7 -17.300[S] KOG4367 Predicted Zn-finger protein  ali follow..  11  156.........DRYQQSKAAALKCLCEKAPK--EATVMCEQCDVFYCDPCRLRCHPPRGPLA----LENHSMYCVQCKM-GAMWKLHKSQLSQALNGLAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVPADGYILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIILSNDNLTVTCSYDDRVVLGKTGFSKGIHYWELTVDRYDNHPDPAFGVARMDVMKDVMLGKDDKAWAMYNNRSWFMHNNSHTNRTEGGITKGATIGVLLDL----------------------------------------------------NRKNLTFFINDEQQGPIAFDNVEGLFFPAVSLNRNVQVTLHTGPDFYSSRASIA..................................................... 710
8 -14.800[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  9  3.....................C-CGVEFTVFRRKRACFDCKRYYCANCIAS-------------------RCKRC----SVFAQRPLSRTDLLKLKPKDL-------------------IFYLQSKEELVGLVLTHVAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFSNLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQATTTNGGSQSSSSPSTSTQSSNNRD....................................................................................................................................................................................................................................................................................................................... 212
9 -13.800[R] KOG1844 PHD Zn-finger proteins  ali follow..  9  101.SSATTISTSEDGSYGTDVTRCICGFTHD-DGYMICCDKCSVWQHIDCMGIDRQHIP-----------TYLCERCQPRN-----------------------------------------------------LDKERAVLLQRRKRENMSDGDTSATESGDE----------------------VPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREAQRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYR-------------------------GKFMLREQFEA-NGYFFKRPYPFVLFYSKFHGLEMC---VD--------------------------------------------------ARTFGNEARFIRNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVD--KENPECPVLKRSSESMENINSGYETRRKKGKKDKDISKEKDTQNQNITLD. 512
10 -13.700[B] COG5034 Chromatin remodeling protein, contains PhD zinc finger  ali follow..  17  231.LVKHDTLDSSDISREGEQLYCYCQQVS----QMIGCDNCKEWFHLPCVGLVEPPKG-----------IWYCKECEELAKSSESRQ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 305
11 -13.200[R] KOG4299 PHD Zn-finger protein  ali follow..  21  245ISSNELLPTPEEYPYRYNNDYC-CHGPGNF----LCCETCPNSFHFTCIDPPIEEKNLPD--------AWYCNECK................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 310
12 -13.000[B] KOG1973 Chromatin remodeling protein, contains PHD Zn-finger  ali follow..  15  258.AATHPSDVMDMPVDPNEPTYCLCHQVS----EMIGCDNCPEWFHFACVGLTTKPKG-----------KWFCPKCTQDRKK........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 327
13 -12.700[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  19  314MAAVKTYRWQ------IECKCCICGTSEN-DDQLLFCDDCDRGYHMYCLT---------PSMSEPPEGSWSCHLCL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 375
14 -12.000[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  18  174..NPNATALKRKSRKVDMVTLCVCQGHSPLSNRIVFCDGCNSPYHQLCHH--DATVQDVD--------EWFCMKCQYRRAK-SDKKMYLSSLPTPHLADLILF..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 286
15 -11.100[O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation  ali follow..  14  172...ANLIPGKARAEYGEQRQYCVCGSMPVSSMVQLHCNLCTEW-RVKCSNCEQSGKLHYWSLDDEQIKAESCDDCGTYLKILYQEKEPKVEAVADDLASLVLDARMEQEGYARSSIN....................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 300
16 -10.800[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  9  9AEGAVKGLPEMLGVPMQQIPQC-CNQDRHWHSSCLKCADCQMQLADRCFSRAGSVY-------FFKRFGTKCTACQQ--------GIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRL--VCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMD.................................................................................................................................................................................................................................. 386
17 -10.200[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  20  173..........NDDVLTKDAGECICLEELLQGD-TIARLPCLCIYHKSCIDSWFEVNR-------------SCPEHPAD.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 227
18 -10.100[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  12  17LLNVLDRAW---HIKCVQCCECYCKND--FRRFGTKCAGCAQ-FHLNC---------------------FTCMVCSTGEELYIDENKFVCKDDYLSSSSLKEGSLNSVSSCTDRSLSPDLQDAL-SSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTPYTYYGDYQG................................................................................................................................................................................................................................................................................................................................... 284
19 -10.100[S] KOG4623 Uncharacterized conserved protein  ali follow..  11  34............RSRYDARVNCFCNGNVRVDRNSWTCPSCEQY-RDCSLGSQKNSSKGSSSICANSYYS-LCDQCNEAQR-----------LKVEKLSQFEPKNES-----------------RFDQELKVYLEKQFRL-------SSCERHVNKVLHEKKKMVLSS..................................................................................................................................................................................................................................................................................................................................................................................................................... 188
20 -10.000[O] KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase  ali follow..  15  94.............EAKDNVSICFCGSKEHSPLKFAKCFICHENGHGQCEQNPKGLYPKGG----------CCKFCSSVHHDCDQVNKDDVSFGHVV--TTGADEDVYHEYAKTVAAPTKKRPVKPVKKLVTF........................................................................................................................................................................................................................................................................................................................................................................................................................................................ 218
21 -10.000[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  18  246.SPPKRVNRDIDESQKEELYKC-C---DSVSKREPVSTKCGHVFCRECIETAIRATH-------------KCPIC--------NKKLTARQFFRIYL........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 319
22 -10.000[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  4  51.........DDKDAIKEAAPKCNCSQRGHLKKKAIQCSKCDEVGHSQCPHKWKKV---------------QCTLCKSKKHSKERCPSIWRAYILVDDNEKAKPKVLPFHTIYCYNCGG---------------KGHFGDDCKEKRSSRVPNEDGSAFTGSNLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLPRPSHKRHSQNDHSHSGRNKRRASNFHPPPYQKSNVIQPTIRGETLSLNNNISKNSRYQNTKVNVS...................................................................................................................................................................................................................................................................................................................... 298
23 -9.970[O] KOG0802 E3 ubiquitin ligase  ali follow..  9  339LGALHAALPDTSEELRAYDDECICREPMA-KAKRLHCN---HLFHLGCLRS----------LDQGLNEVYSCPTCRK---------------------PLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPD........................................................................................................................................................................................................................................................................................................... 579
24 -9.790[TZR] KOG1704 FOG: LIM domain  ali follow..  9  192..EAEGRSW---HFHHFQCAQCVCLKCFHSSSSTFSCTTCRLW-HAEC---------------------FCCCVCSKGVKYSRVGESLFEELLDEDRLGSPHRKVTQKSTKVVRIPASPRVAPRHPHVIQQ--PKPPQRAPPPPPSENIYETVLPCSSNNSPNFDKKYSHELPTSPNHHNYYSKTPNNLLTGYPEMDGYSTSSSSDSDDEQLYISNIMAAASLSRVPAKSSSRKSKKNEPMMMSGGGVRMAKKKKSS........................................................................................................................................................................................................................................................................................................................... 484
25 -9.530[S] COG3791 Uncharacterized conserved protein  ali follow..  12  1.............MKKTYHGSCHCGAVWWTTTFRCNCSSCLKFVTPEDFSLLSGEEALAEYRFGEIRHVF-CRHCGVHPLGSADFEIMGGPFHAVNIACLDDATDEELANAPIVYEDGRHDAWDRSPAVTSYL....................................................................................................................................................................................................................................................................................................................................................................................................................................................... 149
26 -9.480[TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved in axon guidance  ali follow..  8  63..........SSPKETTFSSNCACGRDKQWHLGCFKCKSCGK-FGVKCEAC-HQFITGKVLEAGDKHYHARCSRCNQMFTEGEEMYLQGSTVWHPDCKQTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYIPKVKAIYDIERPDLITYEPFYTSGYDDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSLPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHRALAAQSKSSEDIIKFSKFPAAQAPDPSETPKIETDHWPGPPSFAVVGPDMKRRSSGREEDDEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKESRERSSLLASRYDSPINSASHIPSSKTA-------------SLPG-------------------YGRNGLHRPVSTDFAQYNSYGDVSGGVRDYQTLPDGHMPAMRMDRGVSMPNMLEPKIFPYEMLMVTNRGRNKI-------LREV---RTRLERHLAPEVFREIFGM------------SIQEFDRLPLWRRNDMKKKA 623
27 -9.360[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  8  3.....................C-CKSNEYTNQLVMMINECGHPLCKNCVDNIFALNSGN------------CHVC--------NRVLRKNNFREQIYEDPLIDKETFLRRKLRKIYNLKQDDFENLREFGDYQERK-SNFRRFKNFKNFFYEFSIRYSNSPSFSWSNPEFSAQNETNVNETNAEIQAFEEKHKEQIDRNKRRLDDDQKWIEDQLREERAMKARMTDHMEMDAKEQEAASAVTDTRKIMDELRDSNVAAEVDRERKKQIEKELEEKEEQEKRKRRNKEMLQTRKRAAENMSFNTVIRVAGRAYVHQVGHENSEEIEKMQLFHSKFQIFKSIFRFS-EIEALGYLAHIR-GYTPMLGCSRA---FEARI................................................................................................................................................................................................... 398
28 -9.330[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  11  5....................QC-C---IKPNQTKLYLTACG---HVFCQNCTKAAFNS------------QCYLCKKPRPDLMELFKDPRQLASDLVNELKQVVAFQAKQREIYVKCKNAEAKKDTERFAEARSKHVEKTQEIEKRKKAFLEDNVKLKNAKEE--LMARLKELREQPSQNLSVNKRRSNTRTEPPFSKISRTGPPSVMRKASHEFSLNLRDQSTSKILTSTPLSNIDYSRRDHRNRLFGAGLEHPSPILRQ....................................................................................................................................................................................................................................................................................................................... 240
29 -9.190[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  9  85.SEGIENQNRRMSNGNKVTLRDLVFGPA------VANTKSGILDSIVFPVDTCMDIPAST----------GFSSDE--------VEGSLRDVRKIYASRVAA------------------------------VDD-----EAHKRILFLEAKLRSIEQKTASWSNKEVQWKITEAELRLEVTKLKKKIANMESTTKGSQSQSNVASQEKYIPAHNIYQEHHGQSPSCSFRHQGDLLINGGRIFDIDGGRQILLYARRLSGVGGTFVLTQMSLHSPCEIDDILLPRTTRAIKDLHLSPHNNGLAVFGSLGKKLSV----ISLESHNTVLSYDLPAAPWSCSW-------DLKSSHHIYAGLQNGMVLI-----FD...................................................................................................................................................................................................... 389
30 -9.180[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  9  328DDTLVTVTVEQLQNSANDDNICICWKNKNKKPKRLPCG---HILHLSCLKNWMERSQ-------------TCPICR---------------------LPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKF........................................................................................................................................................................................................................................................................................................................................ 547
31 -9.040[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  8  1MDDEGARK---------VDEKC-CQADRYLN-INPECY------HKMCESCVDRIFTTGP--------QCPTPGC--------NKILRKAKFREQTFEDAQIEREVDVRKRISRIFNKGQQEFDSLQAYNDYLEE---------------EILTFNLIYKIDVEETEEKVKQYEKQNRDSIAANSARAAAEARILAQNEILLKRQKQEAREAAIREHQKEKERREQVEQQIIFDLATSGKDPNKIIQLSDSLKKQQENIASSVSNISRSSSILLSDVQQVAEDTTPFSPLAGEKDGSKYFSYSKNTYQDLYLEKVSHEPGRKC--GFRILRCLYEAFSGIDYD..................................................................................................................................................................................................................................... 307
32 -9.000[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  12  20.PIVSQFKMVNYSYDEDLEELCVCGDKVS----LLTCESCKGFFKRTVQNNKR----------------YTCQNCQ---DKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRN......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 120
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;