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Query: [G] KOG2638 UDP-glucose pyrophosphorylase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSIQPYEKIKARGLPDNISSVLNKLVVVKLNGGLGTSMGCKGPKSLIGVRNENTFLDLTVQQIEHLNKTYNTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLRPVAKDVSYSGENTEAWYPPGHGDIYASFYNSGLLDTFIGEGKEYIFVSNIDNLGATVDLYILNHLINPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNAKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDHLast
1 -159.000[G] KOG2638 UDP-glucose pyrophosphorylase  ali  100  1MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSIQPYEKIKARGLPDNISSVLNKLVVVKLNGGLGTSMGCKGPKSLIGVRNENTFLDLTVQQIEHLNKTYNTDVPLVLMNSFNTDEDTKKILQKYNHCRVKIYTFNQSRYPRINKESLRPVAKDVSYSGENTEAWYPPGHGDIYASFYNSGLLDTFIGEGKEYIFVSNIDNLGATVDLYILNHLINPPNGKRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSKFKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNAKTLDGGLNVIQLETAVGAAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKREFPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLKGTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH 508
2 -94.300[M] KOG2388 UDP-N-acetylglucosamine pyrophosphorylase  ali follow..  12  27.QIELAKILLENGQSHLFQQWPELGVDDKEAFFDQIARLNSSYPGGLAA----YIKTAKELLADSKVGKNPYDGFSPSVP--SGENLTFGTDNFIEMEKRGVVEARNAAFVLVAGGLGERLGYNGIKVALPRETGTCFLQHYIESILALQEASNRDIPFIIMTSDDTHSRTLDLLELNSYFGMKPTQVHLLKQEKVAC--LDDNDARLALDPHNKYSIQIQMDFSSMLVAATQLLCL-----KVFIQFLMEIHNSLMTSLVQAIPASLGVSATKQYHVNSLAVPRKAKEAIGGISKLTHSMVINVEYNQLDPLLRANCETGFSPFPGNINQLILELGPYKDELQKTGGAIKEFVNPKYKDSTKSSTRLECMMQDYPKTLPRVGFTVMDILAYAPVKNNPEDAAKVPKGNPYHPVKQVLNGQEVEVWSRITWKPKWGMIFSDIKKKVSGNCEVSQRSTMAIKGRNVFIKDLSLDGALIVDSIDDAEVKL--GGLIKNNGWT........ 568
3 -86.100[G] COG4284 UDP-glucose pyrophosphorylase  ali follow..  14  2..TDTKQLFIEAGQSQLFHNWESLSRKDQEELLSNLEQISSKR---SPAKLLEDCQNAIKFSLANSSKDTGVEISPLPPTSYESLIGNSKKENEYWRLGLEAIGKGEVAVILMAGGQGTRLGSSQPKGCYDIGSKKSLFQIQAEKLIRLQKDKKVEIPWYIMTSGPTRAATEAYFQEHNYFGLNITFFNQGTLPAFDLTG-----KHFLMKDPVNLSQSPDGNGGLYRAIKENKLNEDFDRRGIKHVYMYCVDNVLSKIADPVF---IGFAIKHGFELATKAVRKRDAHESVGLIATKNEKPCVIEYSEISNELAEDKDGLLKLRAGNIVNHYYLVDLLKRDLDQWCENMPYHIAKKKIPTEPNGIKLEQFIFDVFDTVPLGCLEVDRCKEFSPLKNGPGSKNDNPET--------------------------------------------SRLAYLKLGTSWLEDAGAIVKDGVLVEVSSKLSYAGENLSQFKGKVFDRSGIVLEK 477
4 -16.900[G] COG0448 ADP-glucose pyrophosphorylase  ali follow..  9  1......................................................................................MEVIMNSSIVKLPNKYELVKDTLVLILAGGRGSRLYDKRAKPALYFGGNRRIIDFALSNCL------NSGLNRIGVVTQYAAHSLLRHLQNGWSFLPAERG-----------------EFIDMLPARQQIDDSTWYRGTADAVYQNMAIIRD--HYCPKYILILAGDHIYKQ-----YSQMLLDHIHSGAKCTVGCIEVEREKATEFGVMAVNENLKVKSFVEKPKDPPAMVGKPNT-SLASMGIYVFDADYLYDVLE------------REVSSPYTSHDFGKDILPKALEEGVLYAHPFSRSCMGRNTEGEIYWRDVGTLDSFWQSNIDLVCEN-----PQLDIYDQSWPIRGNPVQTYPSKFFYKKENARPVDNSLISGGCVITDASISYSVLFDRIKINEGSQIDHCVVLPQVTIGKN 378
5 -16.600[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  13  1...................................................................................................MGSSMEEKVVAVIMVGGPGTRLSLNIPKPLFPI-AGQPMVHHPISAC----KRIPNLAQIYLVGFYEEREFALYVSAISNELKVPVRYLREDK---------------------------PHGSAGGLYHFR-----NLIMEDSPSHIFLLNCDVCCSF-----LPKMLEAHRGYGGIGTLLVIKVSPESSQFGELVADPVTNELLHYTEKPETFVSD--------RINCGVYVFTPEIFNAIGDVSTQRKDRATLKRVSSIPTDFVRLDQDILSPLAGKKRLYTYET-MDFWEQIKSPGMSLRCSGLYLSQFRLTSPQLLASGDGTRSAIVIGD-----------------------VYIHPSAKVHPTAKIGPNVSI----SANARVGPGVRLMSCIILDDVEIMEN 347
6 -15.600[M] KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase  ali follow..  7  79.....................................................................................................NADPKNVASIILGGGAGTRLF-KRAKPAVPIGGCYRLIDIPMSNCI------NSGIRKIFILTQFNSFSLNRHLSRTYNFGNGVNFGDGFVEVLAATQTSGDAGKKWF-------------QGTADAVRQFIWVFEDAKTKNVEHVLILSGDHLYRM-----YMNFVQKHIESNADITVSCLPMDESRASDFGLLKIDQSGKIIQFSEKPKGGLPPKEAAESPYIASMGVYVFRKEVLLKLLRSSYPTSNDFGSEIIPLAVGEHNVQAFLFNDYWEDIGTIGSFFDANLALTEQPPKFQFYDQKTPFFTSPRFLPPTKVDKCRILDSIVSHGCFLRECSVQHSIVGIRSRLESGVELMMMGADFYQTEAEIASLLA---EGKVPVGVGQNTKIKNCIIDKNAKIGKN 478
7 -15.100[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  12  5.......................................................................................KKRAAKISEDSEEEQSRRQRLQAILLADSFATKLTLERPNVLLPL-VNIPMIDYTLAWLES------AGIEEVFVFCSMQVIDYLNNSDWYSHKDFTVKTIESPQ-----------------------------SAGDALRYIYEQQIETSQIQGD---FVLVNGCIVSNMPLTQLIQEHRDRKKKDEKAIMTMVIRQSLITDHQLFIAVNPLTKQLLYYDEDNICFDKSLLDRNP-----------SVLLCSDMQDCY-----DICSLEVLSLFVDNFDYQHMRCDFV---EGVLADDIIGYKIFTHEISSCYASRIENFRSYDMVSKDIIQRRTFPYVPDMKFSGN-RTLKLERQGIYKASDATQLPSAHVGASYVIGHATNIGSGTKILNS-GNGCSIGSNVVIQGSYIWNNVTVEDG 374
8 -13.800[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  13  1...........................................................................................................MRAVLMAGGSGTRL-CDLPKPMVPI-LNRPIAEHIINLLKRHH------ITEVIATLHYLPDVLRDYFQDGGDFGVQMTYAVEEDQP-----------------------------------LGTAGCVKNIAELLDETFLVISGDSITDF-----LGEAIAFHKQKQSKATLILTRVPNPIEFGVVITDEAGK--IKRFLEKPSTSEIFSD------TVNTGTYILEPEVLEYL------------------PSNTECDFSKDLFPLLLAKDEPMYGYVAEGYWCDVGHLDAYREAQYDGLDRKVKLDF----------------------RENSPGLWIGQNTYIDPSAHIEAPAVIGNNCRIGARVQIEAGTGDNVTIGADANLKRPIVWNGAIIGEE 314
9 -12.500[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  16  1......................................................................................................MPQNTLNIVILAAGKGTRMYSKMPKVLHEI-GGETMLGRVIDTAAALNPQN------ICVVVGHGKEQVLDTVKRDVVWVEQTEQL---------------------------------GTGHAVKTALPH--------AAEGRTLVLYGDVPLIDVET-----LETLLEAAGNEVGLLTDVPADPSGLGRIIRDSSGSVAIVEEKDADAAQK-------AVKEINTGILVLPNAKLEAWLNS----------------SSNNAQGEYYLTDLIAKAVAHPVQVRSSHLAAGVNNKLQLAELERIFQTEQA-----------------------------QELLKAGVTLRDPARFDLRGRLKHGQDVVIDVNCIFEGKIGDNVEIGANCVIKNAKIGANSKIAPF 311
10 -12.500[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  10  1........................................................................................................MKMRKGIILAGGSGTRL-MAVSKQLLPI-YDKPMIYYPLSTLMLAGIR-----DILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPS---------------------------PDGLAQAFIIGEE----------GGDDCALVLGDNIFYGHD---LPKLMEAAVNKESGATVFAYHVNDPERYGVVEFDKNGT--AISLEEKPLEPKSN--------YAVTGLYFYDNDVVQMA-------------KNLKPSARGELEITDINRIYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIATIEER--------------------------------QGLKVSCPEEIAFRKGFIDVEQVRKLAVPLIK-----NNYGQYLYKMTKDS........... 292
11 -12.500[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  11  2......................................................................SLYEHAALPLASSPSILGPISGGRNRGNIQLQSIPIEFQAVVFAGF-GNSL--ALPKALLPI-GNKPMLHYPLYWLEAAGFT-----SAILICMEEAEAHINAWLRSGYEGHMRIHVEAPTILD------------------------DSKSSADALRAVSHL-SQKMLTDTHQNDFVCLSCD----SIVGLPPIYGLDKFRLDNPSALA-VYSPVLKYEHITSQSKEIDAKQLIGIEEKTSRLLYAKSSADVGSDFTFRMSLLWKHPRVTLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYLQYQKSFTVRENIQRFLSSPNNIDNYDGGLSSQEIKINALIAKDGIICSRANNLPNYFELNKCIAKLTPELVDVTVSERALVGADCMVNEGTTIKDNSNIKKS-GKNCVIGKGVVVSNSILMDNIVVEDG 415
12 -10.100[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  15  1...........................................................................................................MLTLLMCGGKGTRLG-RGEKPLFEV-CGMKLIDHSLLQYKDFDV--------IAITSPHTPATES------------------------------------YLAEKGVEVYRAAGKGDYSEACRELAI---------EPVIVASAD--IVYIRDIAFDIVDAYMKTIKPALTVVMEGEPVG-------------VNIIDSLLINTWQEEEIYSIEKDSVVNVNT---DVERAERLWTTMR................................................................................................................................................................. 173
13 -9.110[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  12  8.............................................................................................................AVIPAAGLGTRF--AQPKEMLPI--DKPAIQYIVEEAAE------SGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHYIRQKE------PLGLGHAVLCAEH----------GDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGVQSVLPEDVSK--GIINTSGSQGHVYEVNDLVEKPSPEEAPSE---IAVMGRYVLNSSIFSVL-------------KTIGRGAGNEIQLTDALREVCR................................................................................................................................... 240
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;