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Query: [K] KOG2652 RNA polymerase II transcription initiation factor TFIIA, large chain, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MACLNPVPKLYRSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATEDFFRNSIQSPLFTLQLPHSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVPAGVTLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSLQATTEKSQRIETVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSHYISLPGVVFSPQVSQTNSDVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLHILKNRMYGCDSVKQPRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPLNSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDAEWLast
1 -157.000[K] KOG2652 RNA polymerase II transcription initiation factor TFIIA, large chain  ali  100  1MACLNPVPKLYRSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATEDFFRNSIQSPLFTLQLPHSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVPAGVTLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSLQATTEKSQRIETVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSHYISLPGVVFSPQVSQTNSDVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLHILKNRMYGCDSVKQPRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPLNSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDAEW 478
2 -106.000[K] COG5149 Transcription initiation factor IIA, large chain  ali follow..  17  1MSN-SIVGEVYHHVILDVIANSRSDFEENGVDDATLRELQNLWQSKLVATDVATFPWAQAPVGTFPIGQLFDPVSGLRTDSLDVTAPAVANSPILNNIAAIRAVQQMDTFAQQHGNSNYYSPPTPSLPQSATNISFDSSAIPNVQSNPNNTAPFPSYSSNSLQLPTNQTADSPIINDHSTANVTSTGQEHAPDSSSTNSFGGLLLPNQNSPKKSELGETESSNTTPANSRNDVPQTDGAI-------------------------------------------------------------------------------------------------------------HDLDDAGSPSNFESNRFAIAQKADAEIYEVLKKNRILQIDGTIEDNEDEKKPPVDTPSDEAINSDLDDPDSDEAPETEEGSDIGQAIVLCLYDKVNHHKNKWKCVFRDGVVGVNGKDYLFFKANGEFEW 368
3 -14.000[R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)  ali follow..  9  590FVGDCQLPIACEMFLDAVRKNLYRNFIDYGIAAETVYKTVQKLQGLLSKYAAGQE-MHKKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDVEQAADAPEVLTHSDNAVDVGIIDDECGGFGAVGVMNGVASPVANNSEMDTEAEVEAEPTATKAITIHCQQPVTTPVAAAATANERLPGVAPHRRGPRRADRREEELVASAPGYRCRPSMRGADAGAAAAAAAAPTHPHPHRPPPP................................................................................................................................................. 951
4 -11.400[U] KOG1091 Ypt/Rab-specific GTPase-activating protein GYP6  ali follow..  9  343....QDLLLVWDEIILAMILYLRSSLLSTENATCCLQRLLNLLQALVLDTDMLSALSINGVFDQSNFVPARTKSCSTSPRSPLIIAPESYWEKKWRVLHKAEEEENKICLEKQTPPTQKKKRWLNVTKLFRAVIDLSHHKLGIGERKANSSPVTQSLLEDSSEQLNVDCHVTVNKENIHPQETEENIMEFHSADEESIVSGSSPSEESSFVSLDPTSPVRCSTKIENDSVSSAGSNLLPDEDDKSIVSISEENSSVSSDPISPAIDSNYSGKYLDCCTGSENDKDQQTSVNSPLSVSPHRRNEYPVTQSDEDVSTDKSVGITKEYKLLHGIVQWFRKLKRTLSSEETSHRKASDATKTNDVKIKKNQIGCYSESHPQALSSGDSSQNLRKTLKNLGQSMLKHIEAIELVFQQEPCLVPAGLIGNLAKTNLIEKGQVATTALKELRKLSN----LLSE--M.................. 840
5 -11.300[TZ] KOG2546 Abl interactor ABI-1, contains SH3 domain  ali follow..  10  7MASENIMDEL-ASLIRTEIPDGRQSLRDSNLERAALEATKNAYQINTLAYSYMQLLELQAQQLGEMESQMNHIAQTVHIHKEKVARREIGVLTANKVSSRQFKIVAPINPEKPIKYVRKPIDYSMLDEIGHGINSAQHSQVRQKHRGSSHGSVQSLLPPSVGPPPTTKPPTPPQMSRAGNTGTLGKSVSNTGTLGKSSREYRTPPVVNPPQVPSHYAPNYPIGHPKRMSTASSTMTTTTTGGGAAGNERAAGYSALPMPPSQQIATHVNLPSAGMMQSLPPPPPTTYDDRSSMPPAPPSPLTVSQHEMTEQSHIGMHTLGRNINRNHFSL-------------------------NFARPGSQSPPLPPPPPPEDEHQDFGRPRTSTGPQLAPIVPEDQNLPGWVPKNFIEKVVAIYDYYADKDDELS--FQESSVLY-----LKKNDDGW-----EGVM--DGVNYV.......... 469
6 -11.000[U] KOG2724 Nuclear pore complex component NPAP60L/NUP50  ali follow..  8  1MNSPTSEQQMNMFRLRDKMSLLNAEFINGYFTEKNHYDFSGTMKSYMDHVAQLKQIYKVDDDVAADMTVPRRTENSSESSGETVAPRKIAKAVRKNGTPKNPLNSTVFAASSPAATVASVPKFGDISVITKETPAPLAKTAEPLVAPAAPATARKRAIRGGGPLGGAESVVFKSGEDGQAATSSVKIPATTIKFPEPTKDFWTKKSDAPAAPSNSGSLFAFLGKELFSIKKNPPIYQNFSGDKPKETPKFSGFSFGKKPAEPSEEPKAADSTPKLT-----------------------------GSPKEADLPKPASSLFGASPSKPLVFGGSSADSTTSAPKPFSALSTAASLFGSSSASTTTTATQPLSFGSSSTGGSSLFSGFAGLAQKAMENQNQAKPEGSGEDDEGEYVPPKVETVENQEPDAVLSSK--------SVFKFTGKYT---KLGVLHIDGKFSVLIRATGTV.. 454
7 -10.700[D] COG5279 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain  ali follow..  11  1MATNLTVKARYG---GDL-------FLEGDI--EVTRIAGSWFYGKLLRNKKCSGYFPHNFVILLEERLNSSTENGRQPSKIVESFEKSNKVVIPPVPSRYSDERPRPKKKLSSSMPNSPKKPVDSLTKARKAKSKEMVNEKNIYNTQSSRHHNNSAPNLPLASHSKPQVRNFEESMNNPLPPLPPLPDLDNMRKTDKRAPKKSYSANDLHMARSSREYNYYKDNQKFYDGFIPEKRYSLEEDSISSGLFSNSQYLNDSACSSENSFALMSDFSATSAGSFARHKYAQSFSDSLQRSQNANGCSTKINDSQEFGDSNASSRNGKMGDILRKIIIPKRNTNIYSSSVSSPKSPKAYPKLPDIQNLNLSATPDEARDWIAVKCHLNRARTLTKYDKHPRYMRALEENRDLILHPQDSIYNGLNTNEVAELNIEYIDKMTW-VLEKL-RGIYIF--ILYRGI--VIG----FLKTPSNKEW 574
8 -10.600[TZ] KOG3671 Actin regulatory protein (Wiskott-Aldrich syndrome protein)  ali follow..  12  285...............DDMDEATKNILKAAGLESNNLNEDDKKFVKKFIAKNYDKYVSVGSLDPSQISSPLPPPIQQHPQMNQSWNQTPVRQYKPSFPSSAPIGSGASSYSTPAAPPPPTRVESHGLAPARPPPPPPSSGTRGIAPSRPLPQAPNYGTPENRPHAVPPPPPPPPPQSFGMAPISSAAPPPPPPPPPMGLPAVGAGAPPPPPPPPPSGAGGPASVLAKLPPAQDGRSNLLAEIQAGKQLRSVQQTADSPKSAGG---------------------------------------------------------------------------------------DARGDVMAQIRQGAQLKHVDAAAEQERRKSTTSGAAGMGGLAGALAKALEERRMNMGIDDTSDDD--DDEDDKNECPSSTILDLKNYRIVNFDKLSYI-------LK--VTNL................ 634
9 -10.600[A] COG5213 Polyadenylation factor I complex, subunit FIP1  ali follow..  17  1.......................................................................................................................................................................................................................................................................................................................................................................................MSNADQHMDVDEDEYLYGETIEERNDGVTVSNAKSPEQASEESDDSDIE-DIDAVPTIDGKNIFEID-LESFDDKWR---KPGA-----SDY-FNYGFDEFTW 151
10 -9.630[K] KOG3227 Calcium-responsive transcription coactivator  ali follow..  9  5MSTPAAIQKM----LDDLIQCIMD-SQNKGTSE---SQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDA......................................................................................................................................................................................... 308
11 -9.560[U] KOG1955 Ral-GTPase effector RALBP1  ali follow..  9  229ITDEQ---QYYVNQFKTIIPGAKEFFTKSKLPILELSHI---WESDFDKDGALTLDE----VARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNF--VDFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQ-VLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQ. 718
12 -9.370[K] KOG2821 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin A  ali follow..  7  1MAAESALQVVLQARLKKLLKYLKDILAETGVGKTV-NSLRKQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKNNIDSIFEVGGVVLCTPDQLYRIEEYWKVHCH--------RDFKEERPEEYESW 626
13 -9.310[R] KOG4377 Zn-finger protein  ali follow..  7  3...........................................KAQHSPQAIFTSFKLERSEYSGPGARLPGGSSSTVATAEDRLSLADHDGSATDLTPSRYRKR--GRVWAPTSSLEQPSKRIVNQPTHFGARSETESRSSRHESLAQPTLQPSEPLETNSSTNLSSTILDKVSVVRAAGTFYPENANSAAQGETPEVVSSRYNSRQESNDLEVDQPEDLSMRPSLPEATATPAVVGPALNMNLLQFKQLIDLYQRQVLLPSFLAAASQPLALPGSAAGPGVSGP................................................................................................................................................................................................ 243
14 -9.300[TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved in axon guidance  ali follow..  8  138...........QFITGKVLEAGDKHYFTEG--EEMYLQGSTVWHPDCKQSTKTEEKLRPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYDDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSLPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHRALAAQSKSSEDIIKFSKFPAAQAPDPSETPKIETDHWPGPPSFAVVGPDMKRRSSGREEDDEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKESRERSSLLASRYDSPINSASHIPSSKTASLPGYGRNGLHRPVSTDFAQYNSYGDVSGGVRDYQTLPDGHMPAMRMD---VSMPNMLEPK-----------IFPYEMLNRGRNK-RTRLE----HLAPEVFIFGMSIQEFDW 614
15 -9.210[TU] KOG3895 Synaptic vesicle protein Synapsin  ali follow..  8  354....QKIGNNYKAMLEQIVDEISELF--GGMEDLVSGRMQNV-RSSVSSRAESPTDEGVAPTPPLPAGPRPAPMGGPPPIPERTSPAVGSIGRLSSRSSISEVPEEPSSSGPSTVGGEIANKKRGRTASETSSGSGPGSVPSSAGPGSGFSSSFLGKQFSFAGKGEGVISTQPTQRPSEEPPAIPTTASSAVRPESSVSVSDSRNTDTLTERAGAGYQPVTNYEQQERVNPFPSKSGSAASIHTSSSSSISSSSISSRINRNGNAIQSPPPPAGPPPPPPTNVTAVGSNANSSSGYRNSFSSSLSKDKTSYGNYGSTTSVETITRMDTNTTNIGATATEAGEASGVTAITNISNSDGIVAPTTGTITTSVTTNDWRSAIGMRSASVYSAPAAVTTVLPGDTSGYDSNSIASQGEGLNNPSDLPSYTRPSYSRSES........................................... 864
16 -9.190[K] KOG3835 Transcriptional corepressor NAB1  ali follow..  11  1MAAALPRTQLYR-ILQKALLSYFDAFIQQGGDD--VQQLCEAGEEEFLEQKALRDWVTNPGLFNQPLTSLPVSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATESEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKK.............................................................................................................................................................................................................................................................................. 227
17 -9.080[A] KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain  ali follow..  8  3......VRRL--KVNE-----LREELQRRGLDTRLAERLQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEED.............................................................................................................................................................................................................................................................................. 202
18 -9.060[Z] KOG3655 Drebrins and related actin binding proteins  ali follow..  10  1MANRAQIVAAWKDVLDDSLEGQTNELKDGGVDE-LNEDLNS-W-SNLLSG--ARNEDDIDLDRLLKKLSTVSSAYSFKEPRGAMEEQKAPVGTNYTRVIPTKELNASVMQDFWKKEEAEEKLRQEAEKESKRLELQKLEQEQRSREEKEHKEREKLVISTTKLQPAHVPIKTSPQPLSPEKTAPGFANNLTDAERMRQARNQEARELIGSRVGAAKAMFTKHTSEGQLQSKLNTQPPAKPARNSIAQRINVFNQNQPQDAPVPSPPRAASPAKPLPVEAPEPVVPAPAIAPAAPVAAEVVSTIAEVEESQPVDDLPLAHESEQFSTIKRSPHSKSNSLQSQSPDETTSSNETDTAVSQEQEEEVRTKVSVTVQQSQSVKSSGMSTLERNALTDLVNEDDFICQETLGDLGQRARALYDYQAADETEIT--FDPGDVIT----HIDQIDEGW------GLGP-DGTNYV.......... 527
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 2 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.