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Query: [E] KOG2965 Arginase, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRILast
1 -96.300[E] KOG2965 Arginase  ali  100  1MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI 354
2 -71.800[E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family  ali follow..  25  11ISLVSNNFGFLRLPVHFNPVETDAEWVITGVPFDASSGRAGTRFGAEAIRRASVNLAWEHCRFPW----DFDVRERLKIVDCGDLVYSFGDNQNFVEELEAHATALLKAGKRCLTFGGDHFITLPLLRAHAKHFGKLAMIHFDAHTDTYENG---SRYDHGTMFYHAPNEG---------------LIDAAHSVQIGIRTEFDRN------LPFTVLSAPQVNEESVAQTVAKIKEVI---GDLPVYLTFDIDCLDPAYAPGTGTPVCGGLSTDRALKILRALKDV-NIVGMDLVEVSPAYDQSDITALAGATLALEMLYMQGAKK............................ 305
3 -66.200[E] KOG2964 Arginase family protein  ali follow..  21  38.PMYSGIATFGRLENVESKRSEDFDIAFIGMPFDTGSYRPGARFGPSSLREGSRRINTKYGAVNLVDCGDIPVTTYDILKAMDQLESAYFQLKPSSFTDHDGFAKNDTVLPRVLSLGGDHTIVLPILRALHRVYGPISVIHFDSHLDTWAPGLIGDGDNHGSYFYFASQEG---------------IMSKDANIHAGIRTPSFSDYDDDVDCGFKIIEAREIDDLGIDGIVKKIRDRV---GDNLVYLSIDIDVLDPAFAPATGTPETGGWSSREMRAILRGLQGL-KFVGADLVEVAPAYDVAEITSLAGAQLLFDIVSMMVKYPLVKEADLSRYMPIHK............. 385
4 -5.940[H] COG1797 Cobyrinic acid a,c-diamide synthase  ali follow..  11  4..........................RLVIAGTHSGVGKTTVTLG-AAFVEKGNIVQGFKCGPDYIDPSYHRAVTKRASRNLDSWMVSEDVVNDIFIEGCNGADLSIIEGVMGFYDGKASTSDKGSTADISLLLQAPVLLVVDISGMARSAAAVVKGFQQLNEKVKIAGVILNGAGSERHAEMCSEAIKEAGIPALGY--LKKGDVPSIPERHLGLVPALERGE--HDSLFSQLAAVVSR--------QFDLERIPSVVKIAVAYDAAFHFYYEENFTLLRQA-------GAELVYFSPLRGEDLPSHCDGLYL--EEFADELSQWIK.......................... 313
5 -5.660[E] KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases  ali follow..  12  171........................KCAVVDVPF--GGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIDINAHACVTGK-PISQGGISATGRGVFHGIENFINQASYM---------------------------------------SILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGEWNPDGID--PKELEDFKLQHGSEGSILEVDCDILIPAAANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSV............................. 470
6 -5.210[B] KOG1344 Predicted histone deacetylase  ali follow..  12  112.........................................................................................RPLRTQTGGTIMAGKLAVERGWAINVGGGFHTLAIKFLFERVEGISRATIIDLDAH--------------QGNGHERDF-------------------MDDKRVYIMDVYNRHPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQELPDVVVYNAGTDILDRRMVRGRRVPISGGYQKRTARIIADSILNL--FGLGLIGPESPSVSAQNSDTPLLPPAV....................................... 346
7 -5.170[R] COG4914 Predicted nucleotidyltransferase  ali follow..  2....................................................................................CLIEPMRLDKYKTALRKVAKSLNEKGVEFVLIGS---AVLPFVYNIDYDPRDVDLFIINKSTVLDNELFEEIAEENDWDMGTSDHGTIYYELIVEGEAVRVDLLENILDIYIPPELLADLKEVDIDGIKVKSIGLEQL-----------LALKAKIATKE--------AEEFINEVARMVLERNIRVDYEKIKKYATAYPEDAEGILKRLRRNGIYIE.................................................... 197
8 -5.120[G] COG3622 Hydroxypyruvate isomerase  ali follow..  12  17..................................................................................................FLERFDAAAKAGFAGVEYLFPYDVEAEAIKARLEANG-LEQVLFNLPAGDWAKGERG--------IACHPDRVQEFREGVDKAIAYARVLGNRQVNCLAGIRPQGHDCASVEKTFVDNLRADKLEAAGIRLVMEQALEIRDKVGSANLFLQYDINHVQLADNPGRHEPGTGEINYRFLFEHLDRIGYQGWIG----CEYKPATTTEAGLGWM............................................ 254
9 -5.040[R] COG4784 Putative Zn-dependent protease  ali follow..  13  30..........................................................................................................................................................................................VQKNDPRAQMGAREHPR----------IVASYGGEYRDAKTERLVARIAGALTAVSENP--QSYRITILNSPAINAFALP--GGYLYRGLLALANDASEVAAVLSHEMGHVTANHGIERQRREEAEVIASRVVAEVLSSDLAGKQALARGKLRLAAFSRQQELQADVI 186
10 -5.030[G] COG2893 Phosphotransferase system, mannose/fructose-specific component IIA  ali follow..  13  5..........................................................................................................................................................................................YVASHGPFARGL--INSLSLLIGDEHGVTPVCAYDGDIVTTEQLEQTLENLIAQANGEEVVVFTDL----------------GGSINNSAAKVLMRHRHVFVVAGVNMTLLLEFLLCEEES-------TDAAITYATNAARESIVFINTLITQPSADLQGESHDQIS. 147

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang Y, Stec B, Godzik A. Between order and disorder in protein structures: analysis of "dual personality" fragments in proteins. Structure. 2007 Sep;15(9):1141-7.