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Query: [T] KOG2996 Rho guanine nucleotide exchange factor VAV3, from COG1018

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDELast
1 -160.000[T] KOG2996 Rho guanine nucleotide exchange factor VAV3  ali  100  1MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE 847
2 -74.800[F] KOG2070 Guanine nucleotide exchange factor  ali follow..  20  1MNSAEQTVTWLITLGVLESPKKTI--SDPEGFLQASLKDGVVLCRLLERLLPGTI--EKVYPEPR-SESECLSNIREFLRGCGASL---RLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTKLSSANISYLMGNLEEICSFQQMLVQSLEECTKPEAQQRVGGCFLNLMPQMKLYLTYCANHPSAVNVLTEHSEELGEF-----ETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDHTDRQDIQKSMAAFKNLSAQCQEVRKRKEL--ELQILTEAIRNWEGDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSPRMSGFIYQGKLPTTGMTITKLE----DSENHRNAFEI-SGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHP.................................................................................................................................................................................................................................................................................................................................. 580
3 -68.900[T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3  ali follow..  16  124.............................................................................................................DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLESFPAEMVNKIFSNISSINAFHSKFLPELEKRMQEWETPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKGSKFTVRTRVGIDGMKIVET-----QNEEYPHTFQVS--GKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNS................................................................................................................................................................................................................................................. 644
4 -52.400[T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)  ali follow..  13  181........DWVTECWKHRDDSYFDVMEPCFVDKHRL--EGLSLF--FHGFKQTEIDDMLRSLENTGGKLAPSPTLATHVVYNPDNDEVETLAVSSNQVHVTKEWFWVSLHRGCCAIEDNFALPTGKLHRKPLESSSVSSPIGKSLRSQNSRSLSSMRDCSVEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEMVETEKNYLSLLKLVVKFKEALECEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNEANNLDFAQVWIDAKEEMKAYPQYINSYDTIKRLFDKQDRENSKFHTFCKAKESNPEFHRLKLTDLMVKPVQRLPSVILLLKEMAKKS-DSKLKNNAEEAAKAIDEVLKTANKTREKNDNFISHLSKFTDIENVPPILVAANRMFIREPIASTSPGLQQFAKMKLFLFHDVLIITKIRSEKQRLARHASFASLHSRQRRPYRYIDNTMRSAFRIRAPDEAKCLELQQQNGSTKPNVFVWCLIHRDEQGGDESNDDEEVRDFLDDIHVKILSDCGRFFY-SSDPSDMNEINDAMVSDMTTRYFRNLCGAKPQYGHGSQMNITEWSHNESFMPPPQSQSRMRRAFSNAQLTLATT............................................................................................................................................................................................................................................. 816
5 -51.300[R] KOG3518 Putative guanine nucleotide exchange factor  ali follow..  17  483..................................................................................................................................ARLNNRPLSSSSICSTSSSSSSGSDQLLNGKLMATSYLASVESLAESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKE-LRVDELQILFANIEEIYEFNSMLLQRLINTGR--DPGRIARCFIDLRDGFDVYTTYCTSYPEAISLLTKLLQATH-TYSLLASTQKLLQ-HRLPLGSYLLKPVQRILKYHLLLDSLRKHC----DVKEVVEAHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWGPELTVLGELRQEGLLMEQH-----NKQRLVLLFATMLIITKQEDGRLQFKTYISQNNLMLSEHLPGE------PTSFYVPFDEPRHQIKLTARNRDQKRIWTQHIKGVMLEKLDIPMRAKELVYQLGNEEGECF................................................................................................................................................................................................................................................................................................................................. 864
6 -45.700[T] COG5422 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases  ali follow..  15  398..............................................................................................................................................EQQARLHLKVQPVLSGGSTSITDKQEEDHRLWSENVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTVIPENNIRCVFHNIMQIHAVNSRLSNALNRTQTLQ--NTIGDLFLDYVPKFEPFIKYGANQAIAKFEFEREKSTNRNFANYVHEVERLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDDNPDTENIPRVIEMIREFLTKLNYETGKTENRLSLLQLNEQLSCSPADFDPSRLLIFKGVVKLKASNGDTENDIHMFLLDNFLLLCKIKIQMKLHLRPLPLELLSISYIEDSPNPPPVKAYGLQLVFIGARFSISLYLNTLIARDQWKQHIEKQQDIIRKRH................................................................................................................................................................................................................................................................................................................................................... 809
7 -42.300[T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac GTPases  ali follow..  18  147..........................................................................................................KIFDNDPTQDEMSSSLLAARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMKIVFGNIHQIYDWHKDFLAELEKCIQE--QDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAE-------YDAYFEEVKQEIN-QRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKALECSDIEKAVELMCLVPKRCNDMMN-----------LGRLQGFEGTLTAQGKLLQQDTFYVIELDAGRTKERRVFLFEQIVIFSELLRKGYMFKRSIKMNYLVLEENVDND------PCKFALMNRETSERVVLQAANADIQQAWVQDINQVLET........................................................................................................................................................................................................................................................................................................................................................ 530
8 -35.800[T] KOG4269 Rac GTPase-activating protein BCR/ABR  ali follow..  16  31...................................................................................................................................GEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGRGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLL-PMKPLKPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPDHPDYPLLQDALRISQNFLSSINE------------DIDPRRTAVTTPKGETRQLVKDG---LVEVSESSRKLRHVFLFTDVLLCAKLKKTQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKAN--KGQSRAIERLKKKMFENEF.............................................................................................................................................................................................................................................................................................................................................. 416
9 -19.900[T] KOG3601 Adaptor protein GRB2, contains SH2 and SH3 domains  ali follow..  28 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
10 -17.400[Z] KOG3565 Cdc42-interacting protein CIP4  ali follow..  14  32.................................................................................................................................................................................................KSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLK---------EQQLKRCVDQLTKIQT--------ELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRQTDLVNIMKALDHLKDYLIAFSRTELEQNTFQFLLENSSKVV--------------------------RDYNLQLFLQENAVF---HKPQPFQFQ----------TSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRASQPDELTIEEHEVLEVIEDGDMEDWVKARN-KVGQVGYVPE-------------------------------------------------------------------------------------------KYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKEDDDGFWEGEFNGRIGVFPSVLVEELS 572
11 -16.900[Z] COG5199 Calponin  ali follow..  28  16....KEVTLWI---------ETVLGEKFEPGTFHSLFKDGVRFCRFLNKVSPLDVKYKE-----SKQIFVQRENICSFINGLKK-LRMNEYELFQTNDLFEAKDLRQVVICLYALSR.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 113
12 -16.500[TZ] KOG2546 Abl interactor ABI-1, contains SH3 domain  ali follow..  12  7.......................................................................................................................................................................................................................................................................................................MASENIMDELASLIRTEIPDGRQSLRD-----LERVADY----DTYYRADNKKAALEATKNTTQSLASVAYQINTLAYSELQAQQLGEMESQMNHIAQTVHIHKEKVARREIGVLTANKVSSRQ------FKIVAPINPEKPIKYVRKPIDYS---------------------------------------------LDEIGHGINSAQHSQVRQKHRG-------------------------------------SSHGSVQSLLPPSVGPPPTTKPPTPPQMSRAGNTGTLGKSVSNTGTLGKSSREYRTPPVVNPPQVPSHYAPNYPIGHPKRMSTASSTMTTTTTGGGAAGNERAAGYSALPMPPSQQIATHVNLPSAGMMQSLPPPPPTTYDDRSSMPPAPPSPLTVSQHEMTEQSHIGMHTLGRNINRNHFSLNFARPGSQSPPLPPPPPPEDEHQDFGRPRTSTGPQLAPIVPEDQNLPGWVPKNFIEKVVAIYDYYADKDDELSFQESSVLYVLKKN-DDGWWEGVMDGVTGLFPGNYVEP.. 471
13 -15.800[T] KOG4792 Crk family adapters  ali follow..  24  2....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPEFDSLPALLEFYKIHYWDTT-QEGSHPQPLGPPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKIN-VSGQWEGGCNGKRGHFPFTHVRLLD 295
14 -15.600[DT] COG5261 Protein involved in regulation of cellular morphogenesis/cytokinesis  ali follow..  11  45....DEAKKWIEEC--------LGTDLGPTSTFEQSLRNGVVLALLVQKFQPDKLIKI----YSNELQFRHSDNINKFLDFIHG-IGLPEIFHFELTDIYEGKNLPKVIYCIHALSYFPLIKSDENLSFTDEDVSIIVRRLRQSNVILPNFKALSADFMLRASPVSSRTPSPTRFPKHARFQTLNSSDSASIKDASARSDILKMHRRTKSATPSLEQFNEPYKQTLPSHSIEFEDSFTTFSAPTRRREALFSTTSGLSQRSPVDEKIVNAIQACGRVRLRLVDMLQSLVEQSSSVVLLQAVIRGYISRNTYRIRKKAYDELVNWVTSIQSISRAYLILQSIIRGGFYRRKYHSLIERLDLFTPSFVLIQSSALGFLTRHAIVNMLDNLYNYIPLFNRM-------QSILRANMFRNEWSNFLDSVQSFPVSFHSICKGRLIRDSINRLNGSLLGELDNFIKLQNLSRGFMI-----RRAFKEKLEKLKASTSSFIALQAIVRAFLLRK---NLESIYDSFQKSHLSVIKAQSLYRGFITRT.................................................................................................................................................................................................................................................................................................................. 613
15 -14.900[Z] KOG2046 Calponin  ali follow..  20  34.QKEAELRSWIKGF--IRP------------DFQKGLKDGIILCTLVNKLQPGSVPK----INGFRVELALARKPLQLPQGNGQ-LRHDPVDLFEANDLFESGNNMQVRVSLLALAG.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 134
16 -14.200[T] KOG4225 Sorbin and SH3 domain-containing protein  ali follow..  16 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
17 -14.100[TUZ] KOG2856 Adaptor protein PACSIN  ali follow..  11  39..............................................................................................................................................................................................SDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWMAFERVSELHLEVKASLMNDDFEKIKNWQKEAF-GFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADPSFNP-EQLKKLQDKIEKCKQDVLKTKE--KYEKSLKELDQGPQYMENMEQVFEQCQQFEE-----------------------------------KRLRFFREVLLEVQK-----------------------------------------------HLNLSNVAGYKAIYHDLEQSIRAADAVE------------------------------------------------------------------------------------------------------------------DLRWFRANHGPGM---------------------AMNWPQFEEWSADLIRTLSRREKKKATDGFTLTGINQTGDQFLPSKPSSTLNVPSNPAQSAQSQSSYNPFEDEDDTGSTVSEKEDIKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLNGQVGLYPANYVEAIQ 486
18 -12.800[U] KOG2215 Exocyst complex subunit  ali follow..  11  1.......................................................................................................................................................................................................MLSNEDGLFQTDAFSPSDYIRDLKGVKIGDETRKLRHLRSEMGALNHASQETLKN---------------------NVFRNY-QQFIDASKEISH-------------------------LEREIYQLTHSLIEQKQVIENLIM----------MTGDDKSSIHTVSSHSTTTSTTNPIQILMQKMEGIGGILNNMSTSEKVILYGEMQFDVETKKPVQKCMLILLSHRLIIGNINAGKYVMESTLSLNSVAPVNVKDRESGAANAGKVLKLL--IFPESRCYLCESARIRTLWFDELEQAKREILHKGSLVRQAT............................................................................................................................................................................................................................................................................................................................................ 260
19 -12.600[S] KOG2995 FOG: SH3 domain  ali follow..  9  16......................................................................................................................................................................................................DLKFKKGDLILIKHRIDNNWFV------QANGQEGTFNYVKVSVPLPMPQCIAMYD-FKMGPNDEEGCLEFKKSTVIQVIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVVTESSSGS-SNSSSTSSSNNCSPNHQISLPNTPQHVVASGSASVRFRDKGAKEKRHSLNALLGGGAPLSLLQTNRHSAEITVQQQMQPNLPWGYLALFP----YKPRQTDELELKK----CVYIVTERCVDG---------FKGKNWLDITGV--YLTPLRARDQQQLMHQWKYVPQNADAQMAQVQQHPVAPDVRLNNMLSMQPPDLPPRQQQATATTTSCSVWSKPVEALFSRKSEPKPETATASTTSSSSSGAVGLMRRLTHMKTRSKS--GASLQQVPKEAISTNVEFTTNPSAKLHPVHVRSGSCPSQLQHSQPLNETPAAKTAAQQQQFLPKQLPSASTNSVSYGSQRVKGSKERPHLICARQSLDAATFRSMYNNAASPPPPTTSVAPAVYAGGQQQVIPGGGAQSQLHANMIIAPSHRKSHSLDASHVLSPSSNMITEAAIKASATTKSPYCTRESRFRCIVPYPPNSDIELELHLGDIIYVQRKQ-KNGWYKGTHTHKTGLFPASFVE... 698
20 -12.600[S] KOG1843 Uncharacterized conserved protein  ali follow..  10  1.............................................................................................................................................................................................................................................................................................................................MGLHNPLPSSLKECKKAGKILTSFVDPRQTLGAQEVIPPSV-------------LTNAKGLVIMTVLKAGF--------------------LFSGRIGS------------LIVARLDDGTWSAPSAVMTGGM-----------------GVGAQIGSELTDFVIILNSKAAVQTFARLGSITLGGNLSIAAGPLGRN----------------------------------------AEAGGGASVGGMAPMFSYSKTKGLFAGVSLEGSVLVERRDANRSLYRGDITAKRLLSGQVAQPAAADPLYRVLNSKIFNLNRGDEGDIYNDVPIYADDEPEDIWGPSSKSTKRRDSADRSSSYSRRGDSYRSNRSRAHDDDDEDDYSFSRSKSLSRKTAGGSLRSSKMDNRRSKYADTPSPRRSRSYSDEDEESVYSSDVSTESSSQFSSRSSEYSKPSRPTAPKPKFKQDSLGPNQARAMYSFAGEQPGDLSFQKGDIIDIVERSGSDDWWTGRIGYREGIFPANYVK... 428
21 -12.400[T] KOG0521 Putative GTPase activating proteins (GAPs)  ali follow..  10  12......................................................................................................................................................................KDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFLDNKNAHNALGKFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPEMQEAANILSASKSCFQHTALDYVITLAQARKVPSI-LSTLLDYYQAHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKMQNRHMSVNRYCDSNTNSTSNKIEGYLFKKKSKGFKTCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDRR-------FCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNACCDCRS.......................................................................................................................................................................................................................................................................................................... 401
22 -12.100[Z] KOG3655 Drebrins and related actin binding proteins  ali follow..  11  4.....................................................................................................................................................................................................................................................................................................SFEKNRAQIVAAWKDVLDDKSDTNWSLFGY---------ELKVVVDELNEDLNSGKIMYAFVRIEDPKTGLNKYL-PVLRKGTCANHIRDVSNLLSGAHLTINARNEDDIDLDRLLKKLSTVSSAYSFK----------EPRGAMEEQKAPVGTNYTRVIPTKELNASVMQDFWKKEEAEEKLRQEAEKESKRLELQKLEQEQRSREEKEHKEREKLVISTTKLQPAHVPIKT--------------------------SPQPLSPEKTAPGFANNLTDAERMRQARNQEARELIGSRVGAAKAMFTKHTSEGQLQSKLNTQPPAKPARNSIAQRINVFNQNQPQDAPVPSPPRAASPAKPLPVEAPEPVVPAPAIAPAAPVAAEVVSTIAEVEESQPVDDLPLAHESEQFSTIKRSPHSKSNSLQSQSPDETTSSNETDTAVSQEQEEEVRTKVSVTVQQSQSVKSSGMSTLERNALTDLVNEDDFICQETLGDLGQRARALYDYQAADETEITFDPGDVITHIDQI-DEGWWQGLGDGTYGLFPANYVEIIN 531
23 -12.000[U] KOG3771 Amphiphysin  ali follow..  10  1....................................................................................................................................................................................................MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQDETKDEQFEQCVQNFNKQLTEGTRLQKDLR------------TYLASVKAMHEASKKLNECLQEVEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGFPDIKSRIAKRGRKLVDYDSARHHYESLQT---------AKKKDEAKIAKAEEELIKAQKVFEEMNVD----------------------LQEELPSLWNSRVGFYV----------------------------------------NTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGS------------------------------------------------NTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLP-----------------------------------------------------------KSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNDEGWLMGELEKCRGVFPENFTER.. 480
24 -11.600[T] KOG4348 Adaptor protein CMS/SETA  ali follow..  35  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MVEAIVEFDYQAQHDDELTISVGEIITNIRKE-DGGWWEGQINGRRGLFPDNFVREIK 57
25 -11.200[U] KOG3875 Peroxisomal biogenesis protein peroxin  ali follow..  24  252...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLLSTHSDEVTDSINWASGEDDHVVARAEYDFAAVSEEEISFRAGDMLNLALKEQQRGWLLASLDGTTGLIPANYVK... 332
26 -10.900[IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation  ali follow..  35  311........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CKALYDFEPENDGELGFHEGDVITLTNQI-DENWYEGMLDGQSGFFPLSYVE... 361
27 -10.500[TZ] KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover  ali follow..  28  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MLKALYDFQAVYPKTISFDEGEYFILYQTSARQNWWQVVMKGNIGFVPSNYVMKIK 58
28 -9.360[D] COG5279 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain  ali follow..  25  14........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VKARYGWSGQTKGDLGFLEGDIMEVTRIAGS--WFYGKLKKCSGYFPHNFVILLE 69
29 -9.240[T] KOG4381 RUN domain-containing protein  ali follow..  9  333VNICKLVVKELLE-QSLRYGRMLDSDHLPLQHFFHVLGHGLLLQSVEHYCPEAQDITASVRDLPTVRT-LMQKKLSDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDSQQGVIDFSLYLRSSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVESLTTTNALMK-------------------EDLAIARNSLLALQAENQAMRQSTSAGDNNSTGSG-------------------GSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDDQINLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLEKKWSHDKSNLGEILKTTSQTLTTQVTASEERAARAEAESRIEREWRISLQEKELKLKEKIANLQGCLKELSEEKERNGKLKADLDKVRTQWSEAQTTLEELGIQLSVSKLKVSEMQDQEREAVGSPGIWAPDSIATHCTACEREFN-LTRRKHHCRSCGEIFCKACSEHTLPLLNAQGKPVRVLLGSLGRSCCSSAKSGFKIQPSCISKI........................................................................................................................................................................................................................................................ 943
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.